CN107019642A - A kind of sustained-release administration type embolism and preparation method thereof - Google Patents
A kind of sustained-release administration type embolism and preparation method thereof Download PDFInfo
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- CN107019642A CN107019642A CN201710210961.9A CN201710210961A CN107019642A CN 107019642 A CN107019642 A CN 107019642A CN 201710210961 A CN201710210961 A CN 201710210961A CN 107019642 A CN107019642 A CN 107019642A
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- sustained
- release administration
- embolism
- cone
- administration type
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/08—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of suppositories or sticks
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of sustained-release administration type embolism.It is loose structure inside the sustained-release administration type embolism, with a head and a cone portion；The head is integrally formed and center overlapping of axles with cone portion, also, the sustained-release administration type embolism is made up of the mixture of Biodegradable polymer material and antibacterial analgesic type drug.
Description
Technical field
The present invention relates to a kind of biologic medical medicine field, more particularly to a kind of sustained-release administration type embolism and its preparation side
Method.
Background technology
After human body fistula lesion resection, bacterium invades original diseased region easily by wound, causes superinfection.
At present, conventional processing mode is to cover wound by medical overcover, and periodically sterilizes to prevent infection.
But this mode not only wastes time and energy, the effect for preventing that bacterium from invading can't be properly arrived at, and can not
Promote the healing of wound.
It would therefore be desirable to which a kind of new Fistula excision post-processing approach, can effectively solve the processing shape of fistula otch
Condition.
The content of the invention
Present invention seek to address that above mentioned problem, and it is an object of the invention to provide a kind of sustained-release administration type embolism,
The embolism has loose structure, can effectively medicament-carried and slow releasing pharmaceutical.Meanwhile, loose structure may insure that embolism has again
Certain intensity, can support wound.It is another object of the present invention to provide the manufacturer of above-mentioned sustained-release administration type embolism
Method, above-mentioned sustained-release administration type embolism is quickly and efficiently prepared using Co 2 supercritical fluid technology.
To achieve these goals, present invention sustained-release administration type embolism a kind of first.Inside the sustained-release administration type embolism
For loose structure, and with a head and a cone portion；The head is integrally formed and center overlapping of axles with cone portion；Wherein,
The head is hemispherical, and radius is 3~7mm；The cone portion is truncated cone, one end of the cone portion and the head
Connection, the other end is hanging, also, the radius of the cone portion and the head junction is 2mm, the cone portion it is hanging one
The radius at end is 1.8mm；Also, the sustained-release administration type embolism is by Biodegradable polymer material and antibacterial analgesic type drug
Mixture be made.
In an embodiment of the present invention, the Biodegradable polymer material is PLA or its copolymer.It is described common
Polymers is for example singly not limited to Poly(D,L-lactide-co-glycolide (PLGA).
In an embodiment of the present invention, the antibacterial analgesic type drug is such as, but not limited to Herba Andrographitis methyl esters.
The present invention also provides a kind of preparation method of above-mentioned sustained-release administration type embolism, and the preparation method is：By what is freezed
After Biodegradable polymer material is placed in a mould with antibacterial analgesic type drug mixture, mould is set to be in carbon dioxide gas
Under atmosphere, 40~100 DEG C of heating simultaneously boosts to 6~30Mpa, and then rapid pressure release, obtains the sustained-release administration type embolism.
In an embodiment of the present invention, the mould is made up of a upper strata and a lower floor, and the upper strata has at least one
Hemispherical groove and a gas injection port corresponding with the hemispherical groove, the radius of the hemispherical groove for 3~
7mm, the gas injection port is connected with the hemispherical groove；The lower floor has at least a frustum of a cone through hole, the circle
One end radius of frustum through hole is 2mm, and other end radius is 1.8mm；Wherein, the hemispherical groove is passed through with the frustum of a cone
Perforation is corresponding, and the hemispherical groove and the center overlapping of axles of the frustum of a cone through hole.
In an embodiment of the present invention, the mould is made of stainless steel.
It should be noted that in the present invention, different antibacterial analgesic type drugs can be selected according to actual requirement.Such as nothing
Specified otherwise, heretofore described reagent is commercial goods.
In the present invention, the structure of the sustained-release administration type embolism is conducive to postoperative operation, can both support wound, again may be used
To prevent foreign matter from flowing into, so as to be conducive to the healing of wound.The inner porosity of the sustained-release administration type embolism is then conducive to
Carrying and medicament slow release, while also ensuring that the embolism has certain intensity.And preparation method of the present invention is utilized, will
After the moulding material of embolism is mixed with load medicine, the pressure leak process under HTHP is utilized so that supercritical carbon dioxide gas can
Quickly through the mould, to form the inner porosity of the embolism.Meanwhile, by carrying medicine and Biodegradable high-molecular
The embolism is made in the mixture of material, it is possible to achieve embolism degraded is synchronous with insoluble drug release to be carried out, and is conducive to extending drug effect,
And then be conducive to wound healing.
Brief description of the drawings
By the following detailed description and appended accompanying drawing, above-mentioned and other object of the invention, feature and advantage will be aobvious
And be clear to, wherein：
Fig. 1 is the structural representation of sustained-release administration type embolism of the present invention；
Fig. 2 is the inner porosity scanning electron microscopic picture of the sustained-release administration type embolism；
Fig. 3 A and 3B are the profile of the levels of mould of the present invention respectively.
Embodiment
Hereinafter, by refer to the attached drawing, some exemplary embodiments to the present invention are described.In the following description, no
Identical label will be marked by with the similar elements shown in accompanying drawing.In addition, in description of the invention below, when this can be caused
When the theme of invention is not known, it will omit the detailed description for the known function contained by this paper and construction.
In addition, when the component of the description present invention, such as first, second, A, B, (a), (b) etc may be used herein
Term.These terms without in define a corresponding assembly essence, order or sequence, and be used only for difference corresponding assembly with
Other assemblies.It should be noted that a component described in the specification is " connection ", " coupling " or " addition " to another
Component, " can also be connected " in the first and second inter-modules, " coupling " or " addition " one the 3rd component, although the first assembly
It is probably to be connected directly, couple or add second component.
Fig. 1 is the structural representation of sustained-release administration type embolism of the present invention；Fig. 2 is that the structure of mould of the present invention is shown
It is intended to.
There is provided a kind of sustained-release administration type embolism 1 in the present embodiment.
Fig. 1 is referred to, as shown in Figure 1, the sustained-release administration type embolism 1 has a head 11 and a cone portion 12.Institute
Head 11 is stated to be integrally formed and center overlapping of axles with cone portion 12.As depicted, the head 11 is hemispherical, and radius is 3
~7mm, preferably 5mm；And the cone portion 12 is truncated cone, one end of the cone portion 12 is connected with the head 11,
The other end is hanging.The radius of the cone portion 12 and the junction of head 11 is 2mm, the half of the hanging one end of the cone portion
Footpath is 1.8mm.
The sustained-release administration type embolism 1 by Biodegradable polymer material and antibacterial analgesic type drug mixture system
Into.The Biodegradable polymer material is PLA or its copolymer.The copolymer is for example singly not limited to polylactic acid-glycolic
Acetic acid copolymer (PLGA).The antibacterial analgesic type drug can be selected according to actual requirement, such as, but not limited to punching
Lotus methyl esters.
In the present embodiment, above-mentioned sustained-release administration type embolism 1 is prepared using the mould shown in Fig. 3 A and 3B.The mould by
One upper strata 21 and a lower floor 22 constitute.
As shown in Figure 3A, the upper strata 21 has at least one hemispherical groove 211 and one and the hemispherical groove
Corresponding gas injection port 212.The radius of the hemispherical groove 211 be 3~7mm, the gas injection port 212 with it is described
Hemispherical groove 211 is connected.The radius that the gas flows into sky 212 is 0.3mm.
Fig. 3 B are referred to, the lower floor 22 has an at least frustum of a cone through hole 221, the frustum of a cone through hole 221
One end radius is 2mm, and other end radius is 1.8mm.Also, the hemispherical groove 211 and the phase of frustum of a cone through hole 221
Correspondence, the hemispherical groove 211 and the center overlapping of axles of the frustum of a cone through hole 221.So, the frustum of a cone through hole
221 both can as the sustained-release administration type embolism 1 mould, the relief hole in pressure leak process can be used as again.
The specific preparation method of above-mentioned sustained-release administration type embolism 1 is as follows.
Pass through known side after the Biodegradable polymer material is well mixed with antibacterial analgesic type drug first
Method carries out frozen dried, and the product obtained after freezing is placed in mould 2 as shown in Figure 3.Then, the mould 2 is put into
In one high-temperature kettle, carbon dioxide is passed through, and the high-temperature kettle is heated, the gas pressure in the high-temperature kettle is reached 6
~30Mpa, temperature reaches 40~100 DEG C.Now, the Biodegradable polymer material and antibacterial analgesic type drug is lyophilized
Body is melted, and Supercritical Conditions are presented in carbon dioxide.Then, rapid pressure release so that the titanium dioxide of supercriticality
Carbon gas enters the mould inside by the gas injection port 212, and is flowed out by the frustum of a cone through hole 221 rapidly.
So, the inner porosity of the sustained-release administration type embolism is formed.The porosity of the loose structure can be by adjusting temperature
Degree and pressure parameter regulation, and then the degradation time and carrying drug ratio of the embolism can be changed.
In the present invention, the structure of the sustained-release administration type embolism is conducive to postoperative operation, can both support wound, again may be used
To prevent foreign matter from flowing into, so as to be conducive to the healing of wound.The inner porosity of the sustained-release administration type embolism is then conducive to
Carrying and medicament slow release, while also ensuring that the embolism has certain intensity.And preparation method of the present invention is utilized, will
After the moulding material of embolism is mixed with load medicine, the pressure leak process under HTHP is utilized so that supercritical carbon dioxide gas can
Quickly through the mould, to form the inner porosity of the embolism.Meanwhile, by carrying medicine and Biodegradable high-molecular
The embolism is made in the mixture of material, it is possible to achieve embolism degraded is synchronous with insoluble drug release to be carried out, and is conducive to extending drug effect,
And then be conducive to wound healing.
Even if described above, the component of one embodiment of the invention is combined into a single unit or as a single list
Atom operation, the present invention is not necessarily limited to an embodiment.That is, in each component, one or more assemblies can be chosen
Combine to selecting property, to be used as one or more units.Although describe the present invention for illustrative purposes one preferably implements
Example, it will be appreciated by those skilled in the art that not departing from the scope and spirit of the present invention as disclosed in appended claims
Under, a variety of modifications, addition or replacement are feasible.The scope of the present invention should be on the basis of appended claims, with a kind of institute
Mode of the technical thought in the suitable scope of the claim with belonging to the present invention is stated to explain.
Claims (5)
1. a kind of sustained-release administration type embolism, it is characterised in that be loose structure inside the sustained-release administration type embolism, and with one
Head and a cone portion；The head is integrally formed and center overlapping of axles with cone portion；Wherein, the head is hemispherical, half
Footpath is 3~7mm；
The cone portion is truncated cone, and one end of the cone portion is connected with the head, and the other end is hanging, also, described
The radius of cone portion and the head junction is 2mm, and the radius of the hanging one end of the cone portion is 1.8mm；Also,
The sustained-release administration type embolism is made up of the mixture of Biodegradable polymer material and antibacterial analgesic type drug.
2. sustained-release administration type embolism as claimed in claim 1, it is characterised in that the Biodegradable polymer material is poly-
Lactic acid or its copolymer.
3. the preparation method of the sustained-release administration type embolism described in claim 1, it is characterised in that the preparation method is：It will freeze
After dry Biodegradable polymer material is placed in a mould with antibacterial analgesic type drug mixture, mould is set to be in titanium dioxide
Under carbon atmosphere, 40~100 DEG C of heating simultaneously boosts to 6~30Mpa, and then rapid pressure release, obtains the sustained-release administration type embolism.
4. preparation method as claimed in claim 3, it is characterised in that the mould is made up of a upper strata and a lower floor, described
Upper strata has at least one hemispherical groove and a gas injection port corresponding with the hemispherical groove, and the hemispherical is recessed
The radius of groove is 3~7mm, and the gas injection port is connected with the hemispherical groove；
The lower floor has an at least frustum of a cone through hole, and one end radius of the frustum of a cone through hole is 2mm, other end radius
For 1.8mm；Wherein,
The hemispherical groove is corresponding with the frustum of a cone through hole, and the hemispherical groove runs through with the frustum of a cone
The center overlapping of axles in hole.
5. preparation method as claimed in claim 4, it is characterised in that the mould is made of stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710210961.9A CN107019642A (en) | 2017-03-31 | 2017-03-31 | A kind of sustained-release administration type embolism and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710210961.9A CN107019642A (en) | 2017-03-31 | 2017-03-31 | A kind of sustained-release administration type embolism and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN107019642A true CN107019642A (en) | 2017-08-08 |
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| CN201710210961.9A Pending CN107019642A (en) | 2017-03-31 | 2017-03-31 | A kind of sustained-release administration type embolism and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198088A (en) * | 2011-05-19 | 2011-09-28 | 山东省医疗器械研究所 | Cervical slow-release suppository for treatment of cervical erosion and preparation method thereof |
| CN103143065A (en) * | 2013-03-19 | 2013-06-12 | 四川大学 | Tissue engineering scaffold with multi-growth-factor sequential release characteristic |
| CN103272276A (en) * | 2013-05-28 | 2013-09-04 | 北京博辉瑞进生物科技有限公司 | Anal fistula suppository and preparation method thereof |
| AU2008289308B2 (en) * | 2007-08-23 | 2013-09-19 | Cook Biotech Incorporated | Fistula plugs and apparatuses and methods for fistula plug delivery |
| CN103654880A (en) * | 2005-04-29 | 2014-03-26 | 库克生物科技公司 | Volumetric grafts for treatment of fistulae and related methods and systems |
-
2017
- 2017-03-31 CN CN201710210961.9A patent/CN107019642A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103654880A (en) * | 2005-04-29 | 2014-03-26 | 库克生物科技公司 | Volumetric grafts for treatment of fistulae and related methods and systems |
| AU2008289308B2 (en) * | 2007-08-23 | 2013-09-19 | Cook Biotech Incorporated | Fistula plugs and apparatuses and methods for fistula plug delivery |
| CN102198088A (en) * | 2011-05-19 | 2011-09-28 | 山东省医疗器械研究所 | Cervical slow-release suppository for treatment of cervical erosion and preparation method thereof |
| CN103143065A (en) * | 2013-03-19 | 2013-06-12 | 四川大学 | Tissue engineering scaffold with multi-growth-factor sequential release characteristic |
| CN103272276A (en) * | 2013-05-28 | 2013-09-04 | 北京博辉瑞进生物科技有限公司 | Anal fistula suppository and preparation method thereof |
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Application publication date: 20170808 |
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