CN106999507A - 用于调节人工晶状体的聚合材料 - Google Patents

用于调节人工晶状体的聚合材料 Download PDF

Info

Publication number
CN106999507A
CN106999507A CN201580063249.XA CN201580063249A CN106999507A CN 106999507 A CN106999507 A CN 106999507A CN 201580063249 A CN201580063249 A CN 201580063249A CN 106999507 A CN106999507 A CN 106999507A
Authority
CN
China
Prior art keywords
polymeric material
silica component
material according
modulus
copolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580063249.XA
Other languages
English (en)
Inventor
T·希尔维斯托里尼
K·雅各布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RAINESKEN Co
Lensgen Inc
Original Assignee
RAINESKEN Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RAINESKEN Co filed Critical RAINESKEN Co
Publication of CN106999507A publication Critical patent/CN106999507A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/34—Silicon-containing compounds
    • C08K3/36—Silica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/54—Silicon-containing compounds
    • C08K5/5403—Silicon-containing compounds containing no other elements than carbon or hydrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • C08L83/08—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/12—Polysiloxanes containing silicon bound to hydrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2383/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
    • C08J2383/04—Polysiloxanes
    • C08J2383/08—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/002—Physical properties
    • C08K2201/006—Additives being defined by their surface area

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

本公开内容一般地涉及用于调节植入患者眼睛的晶状体室内的人工晶状体的聚合材料。本公开内容涉及包括氟硅氧烷聚合物和二氧化硅组分的聚合材料。目前公开的聚合材料既是光学透明的又具有足够低的杨氏模量，使得它可以有效地响应于眼睛的自然调节力并且因而可以用于调节人工晶状体。当用于制造人工晶状体时，本文公开的聚合材料保护晶状体的物理特性，这是因为氟硅氧烷聚合物增加的疏水性允许其有效地抑制来自眼睛的流体扩散和生物材料的粘附。

Description

用于调节人工晶状体的聚合材料
技术领域
本公开内容一般地涉及用于调节植入患者眼睛的晶状体室中的人工晶状体的聚合材料。
背景技术
眼外科手术一直在上升，因为技术进步允许复杂的干预以解决各种眼科病症。过去二十年来，患者接受度增加，因为这种手术被证明是普遍安全并且产生显著改进患者生活质量的结果。
白内障手术是最普通的外科手术之一，全世界进行了超过1600万白内障手术。可以预期的是，随着平均寿命预期继续上升，该数字将继续增加。通常通过从眼睛移除晶状体并且在其位置上植入人工晶状体(“IOL”)治疗白内障。由于常规的IOL装置主要关注远视力，它们未能矫正远视并且仍然需要阅读眼镜。因而，虽然经历标准IOL植入的患者不再经受白内障的模糊，但是他们不能够从近至远、从远至近以及之间距离调节或改变焦距。
矫正眼睛的屈光不正的手术也已经变得非常常见，其中LASIK享有相当大的知名度，其每年进行超过700,000个手术。鉴于屈光不正的高发病率以及该手术的相对安全性和有效性，与使用常规眼镜或隐形眼镜相比，预计越来越多的人会倾向于进行LASIK或其他外科手术。尽管LASIK在治疗近视中是成功的，但对于矫正远视的有效手术干预仍然存在未满足的需要，远视不能通过常规的LASIK手术治疗。
由于几乎每个白内障患者也患有远视，因此对于治疗这两种病症存在交汇的市场需求。虽然医师和在治疗白内障中具有可植入人工晶状体的患者普遍接受，但是矫正远视的类似手术仅占美国白内障市场的5％。因此，在日益老化的人口中，存在解决眼科白内障和/或远视二者的需要。
发明内容
本公开内容涉及包括氟硅氧烷聚合物和二氧化硅组分的聚合材料。目前公开的聚合材料是光学透明的并且具有足够低的杨氏模量，使得它可以有效地响应于眼睛的自然调节力并且因而可以被用于调节人工晶状体。当用于制造人工晶状体时，本文公开的聚合材料保护晶状体的物理特性，因为氟硅氧烷聚合物的增加的疏水性允许它有效地抑制来自眼睛的流体扩散和生物材料的粘附。
因此，在一方面，本文提供的是聚合材料，其包括氟硅氧烷聚合物和至多大约30重量％的二氧化硅组分，其中二氧化硅组分具有至少大约280m2/g的表面积。
在另一方面，本文提供的是可植入的人工晶状体(IOL)，其包括包含氟硅氧烷聚合物和至多大约30重量％的二氧化硅组分的聚合材料，其中二氧化硅组分具有至少大约280m2/g的表面积。
在仍另一方面，本文提供的是人工晶状体(IOL)装置，其包括氟硅氧烷聚合物和至多大约30重量％的二氧化硅组分，其中二氧化硅组分具有至少大约280m2/g的表面积。在一方面，人工晶状体(IOL)装置包括：
(a)第一晶状体，其由氟硅氧烷聚合物和至多大约30重量％的二氧化硅组分构成，其中二氧化硅组分具有至少大约280m2/g的表面积，其具有第一杨氏模量；
(b)沿着中心光轴与第一晶状体间隔开的第二晶状体；和
(c)围绕第一和第二晶状体的圆周部分，该圆周部分包括***边缘；
其中第二晶状体的一部分和圆周部分的一部分的至少一个是由具有第二杨氏模量的材料制成；并且其中第一杨氏模量小于第二杨氏模量。
从以下具体实施方式，所公开的实施方式的其他目的、特征和优势将对本领域技术人员变得明显。然而，应当理解的是，详细描述和具体实例，虽然指示本发明的各种实施方式，但是通过说明而不是限制的方式给出。在本发明的范围内可以做出许多改变和更改而不脱离其精神，并且本发明包括所有这些更改。
具体实施方式
现在将参考以下附图描述本发明的具体的非限制性实施方式。应当理解的是，这些实施方式是通过实例的方式并且仅仅说明了在本发明的范围内的少数实施方式。如在所附的权利要求中所进一步限定，对本发明所属领域的技术人员显而易见的各种改变和更改被认为在本发明精神、范围和意图内。
聚合材料
本公开内容涉及聚合材料，其包括氟硅氧烷聚合物和二氧化硅组分，该聚合材料是光学透明的并且具有足够低的模量，使得它可以有效地响应于眼睛的自然调节力并且因而被用于调节人工晶状体。
在一个实施方式中，目前公开的聚合材料包括氟硅氧烷聚合物和至多大约30重量％的二氧化硅组分。本文所述的氟硅氧烷聚合物是二烷基、二苯基或苯基烷基硅氧烷和氟化二烷基硅氧烷的交联共聚物。通常，氟硅氧烷聚合物是二烷基、二苯基或苯基烷基硅氧烷和三氟烷基(烷基)硅氧烷的交联共聚物，但可以是二苯基和/或苯基烷基硅氧烷、二烷基硅氧烷和三氟烷基(烷基)硅氧烷的三元共聚物或更高级聚合物。在某些实施方式中，氟硅氧烷聚合物是二烷基硅氧烷诸如二甲基硅氧烷和三氟烷基(烷基)硅氧烷诸如3,3,3-三氟丙基甲基硅氧烷的交联共聚物。可以调节二烷基硅氧烷和三氟烷基(烷基)硅氧烷的比率以调节氟硅氧烷聚合物的物理特性。例如，增加三氟烷基(烷基)硅氧烷可以增加所得氟硅氧烷聚合物的疏水性。在一些实施方式中，氟硅氧烷聚合物通常包括至少大约25摩尔％三氟烷基(烷基)硅氧烷，或大约25摩尔％三氟烷基(烷基)硅氧烷，或大约30摩尔％三氟烷基(烷基)硅氧烷，或大约35摩尔％三氟烷基(烷基)硅氧烷，或大约40摩尔％三氟烷基(烷基)硅氧烷，或大约50摩尔％三氟烷基(烷基)硅氧烷或从大约25摩尔％至大约50摩尔％，或从大约25摩尔％至大约40摩尔％三氟烷基(烷基)硅氧烷。
在一个实施方式中，氟硅氧烷聚合物由式(I)表示：
其中：
n和m每个独立地是0至大约500；
t是大约100至大约1000；
每个R1独立地是烷基或芳基；
R2是卤代烷基；
R3是烷基或卤代烷基；
R4和R5独立地是烷基、卤代烷基或芳基；和
每个X是交联剂，其将式(I)的聚合物与式(I)的第二聚合物联接。
在一个实施方式中，n是大约50，或大约100，或大约125，或大约150，或大约200，或大约250，或大约300，或大约350，或大约400，或大约450，或大约500。在一个实施方式中，m是大约50，或大约100，或大约125，或大约150，或大约200，或大约250，或大约300，或大约350，或大约400，或大约450，或大约500。在另一个实施方式中，n是大约100，并且m是大约150。
在任一个实施方式中，t是大约100，或大约125，或大约150，或大约200，或大约250，或大约300，或大约350，或大约400，或大约450，或大约500，或大约550，或大约600，或大约650，或大约700，或大约750，或大约800，或大约850，或大约900，或大约950，或大约1000。
在一个实施方式中，每个R1是烷基。合适的烷基基团包括，但不限于，C1-C6烷基基团，诸如甲基，乙基，正丙基，异丙基，正丁基，叔丁基，正戊基，正己基等。在另一个实施方式中，每个R1是甲基。在一个实施方式中，R3是烷基，诸如对R1限定的。在另一个实施方式中，R3是甲基。在一个实施方式中，R4是烷基，诸如对R1限定的。在另一个实施方式中，R4是甲基。在一个实施方式中，R5是烷基，诸如对R1限定的。在另一个实施方式中，R5是甲基。在又另一个实施方式中，R4和R5是甲基。在仍另一个实施方式中，氟硅氧烷聚合物由式(IA)表示：
其中:
n是从1至大约500；
m是从0至大约500；
t是大约100至大约1000；
R2是卤代烷基；
R3是烷基或卤代烷基；和
每个X是交联剂，其将式(IA)的聚合物与式(IA)的第二聚合物联接。
在一个实施方式中，R2是卤代烷基基团，其包括1至3个卤基(条件是至少一个是氟)取代基。示例性的卤代烷基基团包括，但不限于，氟甲基，2-氟乙基，2,2-二氟乙基和3,3,3-三氟丙基。在一个实施方式中，R2是3,3,3-三氟丙基。
交联剂通常是甲基氢硅氧烷-二甲基硅氧烷共聚物，其具有大约30至大约70摩尔％的甲基-氢含量。在一些实施方式中，交联剂具有从大约5至大约30个重复Si单元(即，聚合度)的链长。
在某些实施方式中，本文提供的聚合材料具有从大约200至大约500，或从大约300至大约500，或大约400，或大约450的聚合度。
为了用作人工晶状体材料，本文所述的聚合材料应当是光学透明的。然而，氟硅氧烷聚合物和二氧化硅组分不是折射率匹配的。因而随着模量增加必须维持聚合材料的光学性能。有利地，可以独立于模量调节目前公开的聚合材料的光学性能。几种不同的因素有助于聚合材料的光学性能，其包括二氧化硅组分的量和颗粒尺寸。
由于氟硅氧烷聚合物的折射率低，考虑的是，二氧化硅组分的颗粒尺寸应当尽可能小以便获得优异的光学特性。在某些实施方式中，本文提供的聚合材料具有从大约1.35至大约1.40，或大约1.37至大约1.39，或大约1.38的折射率。因此，本文所使用的二氧化硅组分具有至少大约280m2/g，或至少大约300m2/g，或至少大约310m2/g，或至少大约320m2/g，或至少大约330m2/g，或至少大约340m2/g，或至少大约350m2/g的表面积。在某些实施方式中，二氧化硅组分具有小于大约11纳米的平均颗粒尺寸。具有直径大约7纳米的平均颗粒尺寸的热解法二氧化硅是特别合适的，因为小的颗粒尺寸不干扰可见光的波长并且有助于固化的组合物中提高的光学分辨率。具有低至7nm的颗粒尺寸的商业热解法二氧化硅是商业上可获得的(例如，CABOT和Sigma)。通常，二氧化硅组分以至多大约30重量％，或27重量％，或大约25重量％，或大约23重量％，或大约20重量％，或大约20至大约30重量％的量存在。
本文所使用的二氧化硅组分是热解的或“活化的”二氧化硅，其已用硅氮烷处理。二氧化硅组分的量应当是使得聚合材料被充分增强，但仍然保持光学透明。用于进行热解法二氧化硅处理的合适的硅氮烷和方法包括小颗粒尺寸热解法二氧化硅的原位反应并且在本领域是公知的。在这些反应中，硅氮烷(例如，六甲基二硅氮烷)容易与热解法二氧化硅上的羟基官能团反应，形成涂布在二氧化硅表面上的三甲基硅氧烷。在某些实施方式中，本文提供的聚合材料具有大约10psi至大约150psi，或大约50psi至大约100psi，或大约70psi的杨氏模量。
也可以调制聚合材料的其他物理特性。在某些实施方式中，本文提供的聚合材料具有大约500psi至大约1200psi，或大约700psi至大约1000psi，或大约900psi的拉伸强度。在某些实施方式中，本文提供的聚合材料具有大约400％至大约1000％，或大约600％的伸长百分率。
本文还提供了制造以上所述聚合材料的方法。在某些实施方式中，方法包括以下步骤：
(a)将乙烯基封端的氟硅氧烷聚合物与至多大约30重量％的二氧化硅组分组合以获得氟硅氧烷基础组合物，其中二氧化硅组分具有至少大约280m2/g的表面积；
(b)添加交联剂和固化剂至氟硅氧烷基础组合物；并且
(c)固化氟硅氧烷基础组合物以获得聚合材料。
可以使用已知的方法由商业上可获得的或从商业来源购买的原材料合成乙烯基封端的氟硅氧烷聚合物。例如，乙烯基封端的三氟丙基甲基硅氧烷–二甲基硅氧烷共聚物，其具有大约25,000至大约35,000的分子量，是从Gelest可商业获得的。可选地，例如，也可以如实施例1中所述合成乙烯基封端的氟硅氧烷聚合物。合适的原材料包括，但不限于，烷基硅氧烷(例如，八甲基环四硅氧烷)，卤代烷基硅氧烷(例如，三氟丙基三甲基环硅氧烷)等。合适的乙烯基封端剂包括，但不限于，乙烯基封端的二甲基硅氧烷低聚物。
在一个实施方式中，氟硅氧烷聚合物具有长链长，具有大于35,000道尔顿，或大于50,000道尔顿以及或大于70,000道尔顿的分子量是期望的。
在一个实施方式中，氟硅氧烷聚合物是式(II)的化合物：
其中:
n和m每个独立地是0至大约500；
t是从大约100至大约1000；
每个R1独立地是烷基或芳基；
R2是卤代烷基；
R3是烷基或卤代烷基；和
R4和R5独立地是烷基、卤代烷基或芳基。
本文所述的聚合材料具有交联度，使得材料具有足够低的模量以最小化在其用作例如调节性人工晶状体期间施加的力引起的任何潜在的变形，但也足够坚固以最小化凝胶的渗透。在某些实施方式中，聚合材料是轻度交联的，具有小于每百份大约5份(pph)，或小于大约4pph，或小于大约2pph，或小于大约1pph，或大约1pph的交联剂。交联剂通常是具有大约30至大约70摩尔％的甲基-氢含量的甲基氢硅氧烷-二甲基硅氧烷共聚物。在一些实施方式中，交联剂具有大约5至大约30个重复Si单元(即，聚合度)的链长。
在一个实施方式中，固化步骤包括添加铂催化剂。铂族金属催化剂可以是任何相容的含铂族金属的催化剂，其已知催化硅氧烷-氢原子加成为硅键合乙烯基自由基。含铂族金属的催化剂可以是相容的任何已知的形式，诸如氯化铂，铂盐，氯铂酸和各种络合物，例如，具有含铂金属基团的硅氧烷络合物。含铂族金属的催化剂可以以任何催化量使用，诸如足以提供基于组合物的总重量至少大约0.1ppm重量的铂族金属(作为单质金属)的量。在某些实施方式中，使用按重量计至少大约10ppm，或至少大约20ppm，或至少30ppm，或至少大约40ppm的铂催化剂。
可植入的人工晶状体(IOL)
植入在眼睛中的装置自然暴露于眼睛中的流体并且流体可以随着时间扩散穿过装置并且对装置的物理特性具有非意欲的和/或不期望的影响。已经尝试用阻挡层涂布眼科装置以防止这种扩散，但这些步骤可能是昂贵且费时的。此外，如果眼科装置在装置内含有室或通道，其含有流体，那么存在该流体可能扩散出其流体室并且进入聚合材料的风险。这导致可以被IOL利用的流体量减少，以及可能改变聚合材料的物理特性。含有氟碳的硅氧烷单体可以提高聚合物对流体扩散的阻力，并且如此，本文所述的聚合材料可以用在眼科装置中以抑制流体扩散到或扩散出装置。
使用已知的成型技术可以由所公开的聚合材料制造IOL，诸如一次性的或抛光的不锈钢模具，其具有材料正确折射光所需形状的模具腔。在实践中，未固化的氟硅氧烷基础组合物以涉及晶状体尺寸、折射率和结构的考虑所确定的量被引入到模具腔中，并且然后固化。可以采用几种使晶状体成型的方法，其包括注射成型、液体注射成型、压缩成型和传递成型。
人工晶状体(IOL)装置
目前公开的人工晶状体可以用在植入患者中的眼内装置中。这种装置在本领域是已知的，并且包括，例如，US7,662,180和US 7,875,661中描述的那些。
在某些实施方式中，目前公开的人工晶状体可以用作两部分调节性IOL装置中的折射率改变晶状体，其中在折射率改变晶状体和主晶状体在晶状体室内彼此滑动接触。在这些***中，折射率改变晶状体的尺寸并且形状为承受并且响应于沿着晶状体的***边缘施加的径向向内的力。相反，主晶状体不参与提供调节性响应并且因而尺寸并且形状为避免干涉或抑制施加至折射率改变晶状体的径向压缩力。这可以通过控制折射率改变晶状体和主晶状体的相对直径和厚度以最大化径向压缩力施加在折射率改变晶状体上的程度并且最小化这些力施加在主晶状体上的程度实现。
因此，在一个实施方式中，本文提供的是人工晶状体(IOL)装置，其包括：
(a)由具有第一杨氏模量的本文所描述的聚合材料组成的第一晶状体；
(b)沿着中心光轴与第一晶状体间隔开的第二晶状体；和
(c)围绕第一和第二晶状体的圆周部分，圆周部分包括***边缘；
其中第二晶状体的一部分和圆周部分的一部分的至少一个由具有第二杨氏模量的材料制成；并且其中第一杨氏模量小于第二杨氏模量。
在实践中，第一晶状体(即，折射率改变晶状体)和第二晶状体(即，主晶状体)在晶状体室内彼此滑动接触。晶状体室填充有具有特定物理和化学特性的流体或凝胶以提高在调节期间由IOL提供的折射率范围。选择流体或凝胶使得它与折射率改变晶状体配合以提供上至至少3屈光度，优选地上至至少5屈光度，优选地上至至少10屈光度且最优选地上至至少15屈光度的足够范围的调节。
此外，由本文所述的聚合材料组成的晶状体在患者中从主晶状体接触而屈曲的可能性减小，因为表面比通常用于IOL的其他聚合物是显著更疏油的。
除了用在IOL中之外，本公开内容的聚合材料也可以用在其他眼科装置，诸如，但不限于，隐形眼镜、人工角膜、囊袋扩张环、角膜嵌体、角膜环、或其他眼科装置。示例性可选的用途将是在***植入领域中，使得聚合物可以用作外部壳样材料以防止内部材料的泄漏。
实施例
实施例1
根据本公开内容的示例性聚合材料制备如下。
乙烯基封端的40摩尔％氟硅氧烷聚合物
用于氟硅氧烷基础化合物的乙烯基封端的40摩尔％氟硅氧烷聚合物制备如下。140份八甲基环四硅氧烷(D4环状物)、100份三氟丙基三甲基环硅氧烷(D3氟环状物)，3.2份乙烯基封端的二甲基硅氧烷低聚物(乙烯基封端剂)和0.1份硅醇钾(potassiumsiloxanolate)催化剂在聚合容器中搅拌并且加热至大约150℃。在150℃，将硅醇钾催化剂添加至聚合容器。一旦通过增加的黏度视觉上观察到聚合，聚合继续大约3小时。
在大约3小时之后，通过用CO2吹扫聚合物1小时使催化剂失活并且在大约150℃至大约180℃的温度下将聚合物暴露于减小的压力(最小27”Hg真空)，直到挥发物含量达到低于大约3％的量。
氟硅氧烷基础化合物
100份的乙烯基封端的40摩尔％氟硅氧烷聚合物、9份六甲基二硅氮烷(HMDZ)和3份水被添加至混合容器(例如，sigma叶片搅拌机)。一旦混合，60份活化的二氧化硅(Tokuyama QS-30C热解法二氧化硅)被分多次添加，直到二氧化硅完全混合到氟硅氧烷聚合物。组合物在80℃下混合大约30分钟，此时混合容器被在真空下加热至大约150℃持续大约3小时。
在大约3小时之后，移除加热和真空。虽然氟硅氧烷基础化合物仍然很热，但是将另外的氟硅氧烷聚合物缓慢添加至聚合容器，直到二氧化硅含量减小至大约25份。然后将氟硅氧烷基础化合物分散在氯化溶剂(即四氯乙烯)中至大约30％固体含量，通过1微米介质过滤器过滤并且经受加热和抽真空以去除溶剂。
包括氟硅氧烷聚合物的聚合材料
将等份的A和B(表1)混合在一起，真空脱气，并且在302°F下在ASTM测试板模具中加压固化大约10分钟。固化的测试板允许在室温下平衡最少3小时。
表1
部分A 部分B
100份氟硅氧烷基础化合物 100份硅氧烷基础化合物
5-15ppm铂催化剂 2份甲基氢硅氧烷交联剂
0.3pph甲基乙烯基环硅氧烷抑制剂
氟硅氧烷聚合物的机械性能在表2中显示。令人惊讶地，当与非氟化硅氧烷聚合物相比时本文所述的氟硅氧烷聚合物展现提高的拉伸强度同时维持低模量。此外，考虑的是，由于低二氧化硅含量，本文所述的氟硅氧烷聚合物保持合适的光学清晰度。
氟硅氧烷聚合物 非氟化硅氧烷聚合物
硬度(肖氏A) 20 20
拉伸强度 900psi 475psi
伸长％ 600％ 300％
100％模量 70psi 65psi
本文描述和要求保护的发明在范围上不受本文公开的具体优选实施方式的限制，因为这些实施方式旨在说明本发明的几个方面。实际上，从前面的描述，除了本文显示和描述的那些之外的本发明的各种更改对本领域技术人员而言将是显示意见。这种更改也旨在落入所附权利要求的范围内。

Claims (26)

1.一种包括氟硅氧烷聚合物和至多大约30重量％的二氧化硅组分的聚合材料，其中所述二氧化硅组分具有至少大约280m2/g的表面积。
2.根据权利要求1所述的聚合材料，其中所述二氧化硅组分具有大约280m2/g至大约350m2/g的表面积。
3.根据权利要求1所述的聚合材料，其包括大约27％、或大约25％、或大约23％、或大约20％的所述二氧化硅组分。
4.根据权利要求1所述的聚合材料，其中所述氟硅氧烷聚合物包括式(I)的聚合物：
其中：
n和m每个独立地是0至大约500；
t是大约100至大约1000；
每个R1独立地是烷基或芳基；
R2是卤代烷基；
R3是烷基或卤代烷基；
R4和R5独立地是烷基、卤代烷基或芳基；并且
每个X是将式(I)的聚合物和式(I)的第二聚合物联接的交联剂。
5.根据权利要求3所述的聚合材料，其中式(I)的氟硅氧烷聚合物以下式(IA)表示：
其中：
n是1至大约500；
m是0至大约500；
t是大约100至大约1000；
R2是卤代烷基；
R3是烷基或卤代烷基；并且
每个X是将式(IA)的聚合物与式(IA)的第二聚合物联接的交联剂。
6.根据权利要求4所述的聚合材料，其中R2是3,3,3-三氟丙基。
7.根据权利要求6所述的聚合材料，其包括至少大约25摩尔％的三氟丙基含量。
8.根据权利要求1所述的聚合材料，其具有大约1.35至大约1.40，或大约1.37至大约1.39，或大约1.38的折射率。
9.根据权利要求1所述的聚合材料，其具有大约500psi至大约1200psi，或大约700psi至大约1000psi，或大约900psi的拉伸强度。
10.根据权利要求1所述的聚合材料，其具有大约400％至大约1000％，或大约600％的伸长百分率。
11.根据权利要求1所述的聚合材料，其具有大约200至大约500，或大约400的聚合度。
12.根据权利要求1所述的聚合材料，其具有大约10psi至大约150psi，或大约50psi至大约100psi，或大约70psi的杨氏模量。
13.一种聚合材料，其包括交联的二烷基硅氧烷-三氟烷基(烷基)硅氧烷共聚物，和至多大约30重量％的二氧化硅组分，其中所述二氧化硅组分具有至少大约280m2/g的表面积。
14.一种聚合材料，其包括交联的二甲基硅氧烷-3,3,3-三氟丙基甲基硅氧烷共聚物和至多大约30重量％的二氧化硅组分，其中所述二氧化硅组分具有至少大约280m2/g的表面积。
15.根据权利要求1-14任一项所述的聚合材料，其中所述交联剂是甲基氢硅氧烷-二甲基硅氧烷共聚物。
16.根据权利要求15所述的聚合材料，其中所述交联剂具有大约5至大约30个重复Si单元的链长。
17.根据权利要求15所述的聚合材料，其中所述交联剂具有大约30至大约70摩尔％的甲基-氢含量。
18.一种可植入的人工晶状体(IOL)，其包括前述权利要求任一项所述的聚合材料。
19.一种制造权利要求1所述的聚合材料的方法，其包括以下步骤：
(a)将乙烯基封端的氟硅氧烷聚合物与至多大约30重量％的二氧化硅组分组合以获得氟硅氧烷基础组合物，其中所述二氧化硅组分具有至少大约280m2/g的表面积
(b)将交联剂和固化剂添加至所述氟硅氧烷基础组合物；和
(c)固化所述氟硅氧烷基础组合物以获得所述聚合材料。
20.根据权利要求19所述的方法，其中步骤b)包括：
添加所述交联剂至步骤a)的所述氟硅氧烷基础组合物的第一部分，并且添加所述固化剂至步骤a)的所述氟硅氧烷基础组合物的第二部分，并且
在步骤c)之前将所述第一部分和所述第二部分混合。
21.根据权利要求19或20所述的方法，其中所述氟硅氧烷基础组合物的第一部分进一步包括抑制剂。
22.根据权利要求19-21任一项所述的方法，其中所述固化剂是铂催化剂。
23.根据权利要求19-22任一项所述的方法，其中所述二氧化硅组分具有大约280m2/g至大约350m2/g的表面积。
24.根据权利要求19-23任一项所述的方法，其中通过将二氧化硅与六甲基二硅氮烷和水接触提供所述二氧化硅组分。
25.一种人工晶状体(IOL)装置，其包括由权利要求1-17任一项所述的聚合材料构成的晶状体。
26.一种人工晶状体(IOL)装置，其包括：
(a)由权利要求1-17任一项所述的聚合材料构成的第一晶状体，其具有第一杨氏模量。
(b)沿着中心光轴与所述第一晶状体间隔开的第二晶状体；和
(c)围绕所述第一和第二晶状体的圆周部分，所述圆周部分包括***边缘；
其中所述第二晶状体的一部分和所述圆周部分的一部分的至少一个由具有第二杨氏模量的材料制造；并且
其中所述第一杨氏模量小于所述第二杨氏模量。
CN201580063249.XA 2014-09-23 2015-09-22 用于调节人工晶状体的聚合材料 Pending CN106999507A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462054303P 2014-09-23 2014-09-23
US62/054,303 2014-09-23
PCT/US2015/051512 WO2016049059A1 (en) 2014-09-23 2015-09-22 Polymeric material for accommodating intraocular lenses

Publications (1)

Publication Number Publication Date
CN106999507A true CN106999507A (zh) 2017-08-01

Family

ID=55581910

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580063249.XA Pending CN106999507A (zh) 2014-09-23 2015-09-22 用于调节人工晶状体的聚合材料

Country Status (5)

Country Link
US (2) US10647831B2 (zh)
EP (1) EP3197462A4 (zh)
JP (1) JP6754755B2 (zh)
CN (1) CN106999507A (zh)
WO (1) WO2016049059A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114712026A (zh) * 2022-05-12 2022-07-08 温州医科大学附属眼视光医院 一种构建全混浊型白内障动物模型的方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011137191A1 (en) 2010-04-27 2011-11-03 Ramgopal Rao Accommodating intraocular lens device
US9220590B2 (en) 2010-06-10 2015-12-29 Z Lens, Llc Accommodative intraocular lens and method of improving accommodation
US9364318B2 (en) 2012-05-10 2016-06-14 Z Lens, Llc Accommodative-disaccommodative intraocular lens
JP6625975B2 (ja) 2013-11-01 2019-12-25 レンスゲン、インコーポレイテッド 調節性眼内レンズデバイス
WO2015066532A1 (en) 2013-11-01 2015-05-07 Daniel Brady Two-part accommodating intraocular lens device
US10004596B2 (en) 2014-07-31 2018-06-26 Lensgen, Inc. Accommodating intraocular lens device
WO2017096087A1 (en) 2015-12-01 2017-06-08 Daniel Brady Accommodating intraocular lens device
WO2017205811A1 (en) 2016-05-27 2017-11-30 Thomas Silvestrini Lens oil having a narrow molecular weight distribution for intraocular lens devices
EP3503843B1 (en) 2016-08-24 2023-11-15 Carl Zeiss Meditec AG Dual mode accommodative-disacommodative intraocular lens
JP7302503B2 (ja) * 2020-02-26 2023-07-04 信越化学工業株式会社 吸湿性シリコーン樹脂組成物、有機ｅｌ素子用透明封止材、有機ｅｌ素子用透明乾燥材、およびこれらの使用方法
US11357620B1 (en) 2021-09-10 2022-06-14 California LASIK & Eye, Inc. Exchangeable optics and therapeutics
CN115116566B (zh) * 2022-01-18 2023-11-21 中山大学中山眼科中心 一种人工晶状体材料的筛选方法和***

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032502A (en) * 1975-10-10 1977-06-28 Dow Corning Corporation Organosiloxane compositions for liquid injection
US5236970A (en) * 1987-02-05 1993-08-17 Allergan, Inc. Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses
US5312860A (en) * 1992-09-10 1994-05-17 Shin-Etsu Chemical Co., Ltd. Heat-curable silicone rubber composition and cured product thereof
US20020071856A1 (en) * 2000-04-12 2002-06-13 Dillingham Keith Alfred Injectable intraocular accommodating lens
CN1422166A (zh) * 2000-04-12 2003-06-04 法马西雅格罗宁根股份有限公司 可注射的眼内透镜
US20100204787A1 (en) * 2009-02-10 2010-08-12 Stephen Van Noy Accommodative intraocular lens system

Family Cites Families (301)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4373218A (en) 1980-11-17 1983-02-15 Schachar Ronald A Variable power intraocular lens and method of implanting into the posterior chamber
US4512040A (en) 1982-06-09 1985-04-23 Mcclure Hubert L Bifocal intraocular lens
US4720286A (en) 1984-07-20 1988-01-19 Bailey Kelvin E Multifocus intraocular lens
US4585457A (en) 1985-05-16 1986-04-29 Kalb Irvin M Inflatable intraocular lens
US4731078A (en) 1985-08-21 1988-03-15 Kingston Technologies Limited Partnership Intraocular lens
US5059668A (en) * 1986-01-20 1991-10-22 Shin-Etsu Chemical Co., Ltd. Fluorosilicone rubber composition
US4842601A (en) 1987-05-18 1989-06-27 Smith S Gregory Accommodating intraocular lens and method of implanting and using same
US5074876A (en) 1987-12-04 1991-12-24 Kelman Charles D Two piece intraocular lens
US4888012A (en) 1988-01-14 1989-12-19 Gerald Horn Intraocular lens assemblies
EP0328117B1 (en) 1988-02-12 1994-12-28 Menicon Co., Ltd. Processes for production of a Baloon for an intraocular lens
US4822360A (en) 1988-03-16 1989-04-18 University Of Utah Inflatable, intraocular lens and method of implanting the lens in the capsule of an eye
US4932966A (en) 1988-08-15 1990-06-12 Storz Instrument Company Accommodating intraocular lens
US4882368A (en) * 1988-09-26 1989-11-21 Dow Corning Corporation Low compression set fluorosilicone rubber
US4892543A (en) 1989-02-02 1990-01-09 Turley Dana F Intraocular lens providing accomodation
US5227447A (en) 1989-12-07 1993-07-13 Shin-Etsu Chemical Co., Ltd. Preparation of high molecular weight organopolysiloxane
US5152788A (en) 1989-12-27 1992-10-06 Minnesota Mining And Manufacturing Company Multifocal diffractive ophthalmic lens and method of manufacture
JPH03202102A (ja) 1989-12-28 1991-09-03 Toray Dow Corning Silicone Co Ltd オルガノポリシロキサン成形物中のシロキサンオリゴマー量の減少方法
US6197059B1 (en) 1990-04-27 2001-03-06 Medevec Licensing, B.V. Accomodating intraocular lens
WO1992017132A1 (de) 1991-03-25 1992-10-15 Albert Daxer Kunstlinse
FR2681524B1 (fr) 1991-09-25 1997-04-04 Mnao Implant cristallinien.
US5171773A (en) * 1991-11-13 1992-12-15 Dow Corning Corporation High strength fluorosilicone rubber
US5275623A (en) 1991-11-18 1994-01-04 Faezeh Sarfarazi Elliptical accommodative intraocular lens for small incision surgery
US5278258A (en) * 1992-05-18 1994-01-11 Allergan, Inc. Cross-linked silicone polymers, fast curing silicone precursor compositions, and injectable intraocular lenses
US5264522A (en) * 1992-09-10 1993-11-23 Shin-Etsu Chemical Co., Ltd. Heat-curable fluorosilicone rubber composition and cured product thereof
US5443506A (en) 1992-11-18 1995-08-22 Garabet; Antoine L. Lens with variable optical properties
US5336487A (en) 1993-03-05 1994-08-09 Refojo Miguel F Method of treating eye disorders with silicon/fluorosilicone copolymer oil
US5447987A (en) * 1993-12-24 1995-09-05 Shin-Etsu Chemical Co., Ltd. Organopolysiloxane compositions
JP3447296B2 (ja) 1994-01-31 2003-09-16 ボシュ アンド ロム インコーポレイテッド コンタクトレンズの超臨界流体での処理
US5489302A (en) 1994-05-24 1996-02-06 Skottun; Bernt C. Accommodating intraocular lens
EP0767809B1 (en) * 1994-06-30 2004-01-21 Minnesota Mining And Manufacturing Company Cure-indicating molding and coating composition
US5607472A (en) 1995-05-09 1997-03-04 Emory University Intraocular lens for restoring accommodation and allows adjustment of optical power
US5774274A (en) 1995-05-12 1998-06-30 Schachar; Ronald A. Variable focus lens by small changes of the equatorial lens diameter
JPH09150002A (ja) 1995-11-29 1997-06-10 Shin Etsu Chem Co Ltd シリコーンオイルの精製方法
US5665794A (en) * 1996-05-20 1997-09-09 Dow Corning Corporation Method for controlling cure initiation and curing times of platinum group metal curing fluorosilicone compositions
US5902523A (en) * 1996-06-26 1999-05-11 Allergan IOLs and production methods for same
DE19654488A1 (de) 1996-12-27 1998-07-02 Sueddeutsche Kalkstickstoff Verfahren zur Fraktionierung viscoser Silicone
JPH10316860A (ja) * 1997-03-19 1998-12-02 Dow Corning Asia Ltd 光学用シリカ含有ポリシロキサン樹脂
US5854310A (en) * 1997-07-21 1998-12-29 Dow Corning Corporation Curable fluorosilicone composition having improved lubricity
US6361561B1 (en) 1998-10-13 2002-03-26 Pharmacia & Upjohn Ab Injectable intraocular lens
US6197057B1 (en) 1998-10-27 2001-03-06 Gholam A. Peyman Lens conversion system for teledioptic or difractive configurations
US6117171A (en) 1998-12-23 2000-09-12 Skottun; Bernt Christian Encapsulated accommodating intraocular lens
US7662179B2 (en) 1999-04-09 2010-02-16 Sarfarazi Faezeh M Haptics for accommodative intraocular lens system
US20060238702A1 (en) 1999-04-30 2006-10-26 Advanced Medical Optics, Inc. Ophthalmic lens combinations
US20030060881A1 (en) 1999-04-30 2003-03-27 Advanced Medical Optics, Inc. Intraocular lens combinations
US6767363B1 (en) 1999-11-05 2004-07-27 Bausch & Lomb Surgical, Inc. Accommodating positive and negative intraocular lens system
US6551354B1 (en) 2000-03-09 2003-04-22 Advanced Medical Optics, Inc. Accommodating intraocular lens
US20050251254A1 (en) 2000-06-02 2005-11-10 Brady Daniel G Method of implanting accommodating intraocular lenses
US6730123B1 (en) 2000-06-22 2004-05-04 Proteus Vision, Llc Adjustable intraocular lens
AU2001273683A1 (en) 2000-07-11 2002-01-21 The Johns Hopkins University School Of Medicine Device for inserting an injectable bag intraocular lens within a human eye
US8062361B2 (en) 2001-01-25 2011-11-22 Visiogen, Inc. Accommodating intraocular lens system with aberration-enhanced performance
US7780729B2 (en) 2004-04-16 2010-08-24 Visiogen, Inc. Intraocular lens
US20030078657A1 (en) 2001-01-25 2003-04-24 Gholam-Reza Zadno-Azizi Materials for use in accommodating intraocular lens system
US7226478B2 (en) 2001-01-25 2007-06-05 Visiogen, Inc. Optic configuration for intraocular lens system
US20040148023A1 (en) 2001-02-15 2004-07-29 Shu Stephen K. High gain wide range accommodating intraocular lens for implant into the capsular bag
US20020120329A1 (en) 2001-02-28 2002-08-29 Allergan Sales, Inc. Moveable intraocular lenses and combinations of intraocular lenses
US6855164B2 (en) 2001-06-11 2005-02-15 Vision Solutions Technologies, Llc Multi-focal intraocular lens, and methods for making and using same
US20030105522A1 (en) 2001-06-11 2003-06-05 Glazier Alan N. Multi-focal intraocular lens
US7229475B2 (en) 2001-06-11 2007-06-12 Vision Solutions Technologies, Inc. Multi-focal intraocular lens, and methods for making and using same
IL145015A0 (en) 2001-08-21 2002-06-30 Nun Yehoshua Ben Accommodating lens
US20030060878A1 (en) 2001-08-31 2003-03-27 Shadduck John H. Intraocular lens system and method for power adjustment
US7097660B2 (en) 2001-12-10 2006-08-29 Valdemar Portney Accommodating intraocular lens
JP3985133B2 (ja) * 2001-12-21 2007-10-03 信越化学工業株式会社 チキソ性含フッ素硬化性組成物及びこれを用いた封止物
US8048155B2 (en) 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
US20050021139A1 (en) 2003-02-03 2005-01-27 Shadduck John H. Ophthalmic devices, methods of use and methods of fabrication
US7261737B2 (en) 2002-12-12 2007-08-28 Powervision, Inc. Accommodating intraocular lens system and method
US20070100445A1 (en) 2003-02-03 2007-05-03 Shadduck John H Intraocular lenses and business methods
US6860601B2 (en) 2002-02-06 2005-03-01 John H. Shadduck Adaptive optic lens system and method of use
US20030181749A1 (en) 2002-03-21 2003-09-25 Kunzler Jay F. Supercritical fluid extraction of vitreoretinal silicone tamponades
US6695881B2 (en) 2002-04-29 2004-02-24 Alcon, Inc. Accommodative intraocular lens
WO2004010904A1 (en) 2002-07-29 2004-02-05 Yosef Gross Tensioning intraocular lens assembly
AU2002950469A0 (en) * 2002-07-30 2002-09-12 Commonwealth Scientific And Industrial Research Organisation Improved biomedical compositions
US6966649B2 (en) 2002-08-12 2005-11-22 John H Shadduck Adaptive optic lens system and method of use
FR2844703B1 (fr) 2002-09-25 2005-07-08 Alain Nicolas Gilg Dispositif intraoculaire pour restaurer l'accommodation de l'oeil atteint de presbytie
US7125422B2 (en) 2002-10-25 2006-10-24 Quest Vision Technology, Inc. Accommodating intraocular lens implant
US20040082993A1 (en) 2002-10-25 2004-04-29 Randall Woods Capsular intraocular lens implant having a refractive liquid therein
US6836374B2 (en) 2002-11-20 2004-12-28 Powervision, Inc. Lens system and methods for power adjustment
US20040111152A1 (en) 2002-12-10 2004-06-10 Kelman Charles David Accommodating multifocal intraocular lens
US7438723B2 (en) 2002-12-12 2008-10-21 Powervision, Inc. Lens system and method for power adjustment using externally actuated micropumps
CA2507694C (en) 2002-12-12 2012-07-31 Victor Esch Accommodating intraocular lens system and method
US10835373B2 (en) 2002-12-12 2020-11-17 Alcon Inc. Accommodating intraocular lenses and methods of use
US7247168B2 (en) 2002-12-12 2007-07-24 Powervision, Inc. Accommodating intraocular lens system and method
US7637947B2 (en) 2002-12-12 2009-12-29 Powervision, Inc. Accommodating intraocular lens system having spherical aberration compensation and method
US8361145B2 (en) 2002-12-12 2013-01-29 Powervision, Inc. Accommodating intraocular lens system having circumferential haptic support and method
US8328869B2 (en) 2002-12-12 2012-12-11 Powervision, Inc. Accommodating intraocular lenses and methods of use
US7217288B2 (en) 2002-12-12 2007-05-15 Powervision, Inc. Accommodating intraocular lens having peripherally actuated deflectable surface and method
US6616691B1 (en) 2003-01-10 2003-09-09 Alcon, Inc. Accommodative intraocular lens
US7238201B2 (en) 2003-02-13 2007-07-03 Visiogen, Inc. Accommodating intraocular lens system with enhanced range of motion
CA2517576A1 (en) 2003-03-06 2004-09-23 John H. Shadduck Adaptive optic lens and method of making
US7223288B2 (en) 2003-05-21 2007-05-29 Alcon, Inc. Accommodative intraocular lens
US20040249455A1 (en) 2003-06-09 2004-12-09 Tran Son Trung Accommodative intraocular lens system
GB0319408D0 (en) 2003-08-19 2003-09-17 Chawdhary Satish Intraocular device
DE10346024B4 (de) 2003-08-26 2019-01-17 Carl Zeiss Meditec Ag Ciliarmuskel-betätigtes, akkommodationsfähiges Linsenimplantat
DE20316792U1 (de) 2003-08-26 2005-01-05 Schedler, Markus Ciliarmuskel-betätigtes, akkommodationsfähiges Linsenimplantat
WO2005048882A1 (en) 2003-11-18 2005-06-02 Medennium, Inc. Accommodative intraocular lens and method of implantation
US20050137703A1 (en) 2003-12-05 2005-06-23 Vanderbilt University Accommodative intraocular lens
US20050131535A1 (en) 2003-12-15 2005-06-16 Randall Woods Intraocular lens implant having posterior bendable optic
NL1025622C2 (nl) 2004-03-03 2005-09-07 Accolens Internat B V Twee tezamen een lens vormende optische elementen met variabele optische sterkte voor gebruik als intra-oculaire lens.
US7150760B2 (en) 2004-03-22 2006-12-19 Alcon, Inc. Accommodative intraocular lens system
US20110118834A1 (en) 2004-03-31 2011-05-19 Yuhwa Lo Fluidic intraocular lens systems and methods
BRPI0508760A (pt) 2004-03-31 2007-08-28 Univ California dispositivo de lente, conjunto de óculos, sistema, aparelho multilente, sistema de lente zoom, e métodos para fabricar e operar um dispositivo de lente
US7453646B2 (en) 2004-03-31 2008-11-18 The Regents Of The University Of California Fluidic adaptive lens systems and methods
US8018658B2 (en) 2004-03-31 2011-09-13 The Regents Of The Univeristy Of California Fluidic adaptive lens systems and methods
IL161706A0 (en) 2004-04-29 2004-09-27 Nulens Ltd Intraocular lens fixation device
US9005282B2 (en) 2004-04-30 2015-04-14 Calhoun Vision, Inc. Intraocular lens system with injectable accommodation material
US9713527B2 (en) 2004-04-30 2017-07-25 Rxsight, Inc. Multilens intraocular lens system with injectable accommodation material
US7063723B2 (en) 2004-07-23 2006-06-20 Sun Ran Intraocular lens with an accommodating capability
US20100057095A1 (en) 2004-08-18 2010-03-04 Leonid Orbachevsky Method of Refraction Surgery of the Eye and a Tool for Implanting Intraocular Refractive Lens
US7806929B2 (en) 2004-08-27 2010-10-05 Brown David C Intracapsular pseudophakic device
US20060069178A1 (en) * 2004-09-24 2006-03-30 Bausch & Lomb Incorporated Method for polymerizing ophthalmic devices
CA2580142A1 (en) 2004-10-13 2006-04-20 Nulens Ltd Accommodating intraocular lens (aiol), and aiol assemblies including same
US9872763B2 (en) 2004-10-22 2018-01-23 Powervision, Inc. Accommodating intraocular lenses
SE0403093D0 (sv) 2004-12-20 2004-12-20 Amo Groningen Bv New polysiloxanes; synthesis and use thereof
SE0403091D0 (sv) * 2004-12-20 2004-12-20 Amo Groningen Bv New composition for injectable ophtalmic lenses
US20120071972A1 (en) 2004-12-29 2012-03-22 Iris Ginron Zhao Multiphase eyecare
US8216306B2 (en) 2005-01-13 2012-07-10 Minas Theodore Coroneo Ocular auto-focusing lenses
NL1029041C1 (nl) 2005-03-09 2006-09-12 Akkolens Int Bv Verbeterde constructie van een intra-oculaire kunstlens.
CN101203192B (zh) 2005-03-30 2010-09-15 纽镜有限公司 可调节人工晶状体组件及其分离元件
US20060241752A1 (en) 2005-04-20 2006-10-26 Israel Henry M Accommodating multiple lens assembly
ES2650563T3 (es) 2005-05-13 2018-01-19 Akkolens International B.V. Lente intraocular artificial para acomodación por movimiento del iris
DE502005007656D1 (de) 2005-05-27 2009-08-20 Wavelight Laser Technologie Ag Intraokularlinse
GB2427484A (en) 2005-06-21 2006-12-27 Global Bionic Optics Pty Ltd Variable power fluid lens with flexible wall
US7591849B2 (en) 2005-07-01 2009-09-22 Bausch & Lomb Incorpoted Multi-component accommodative intraocular lens with compressible haptic
US20070016293A1 (en) 2005-07-18 2007-01-18 Alcon, Inc. Accommodative intraocular lens system
US8038711B2 (en) 2005-07-19 2011-10-18 Clarke Gerald P Accommodating intraocular lens and methods of use
US20070032868A1 (en) 2005-08-08 2007-02-08 Randall Woods Capsular shape-restoring device
US7316713B2 (en) 2005-08-29 2008-01-08 Alcon, Inc. Accommodative intraocular lens system
US9629712B2 (en) 2005-09-01 2017-04-25 Donald C. Stenger Accommodating intraocular lens
US8034107B2 (en) 2005-09-01 2011-10-11 Stenger Donald C Accommodating intraocular lens
JP4927371B2 (ja) 2005-09-28 2012-05-09 興和株式会社 眼内レンズ
US9636213B2 (en) 2005-09-30 2017-05-02 Abbott Medical Optics Inc. Deformable intraocular lenses and lens systems
US20070088433A1 (en) 2005-10-17 2007-04-19 Powervision Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use
US8603164B2 (en) 2005-10-27 2013-12-10 Gholam A. Peyman Adjustable fluidic telescope
US20070118216A1 (en) 2005-11-21 2007-05-24 Joel Pynson Accommodative intraocular lens
US7981155B2 (en) 2005-12-07 2011-07-19 C&C Vision International Limited Hydrolic accommodating intraocular lens
US20070129800A1 (en) 2005-12-07 2007-06-07 C&C Vision International Limited Hydrolic accommodating intraocular lens
US7985253B2 (en) 2005-12-07 2011-07-26 C&C Vision International Limited Hydrolic accommodating intraocular lens
CA2630854C (en) 2005-12-14 2016-01-26 Novartis Ag Method for preparing silicone hydrogels
US20070260308A1 (en) 2006-05-02 2007-11-08 Alcon, Inc. Accommodative intraocular lens system
WO2007134019A2 (en) 2006-05-08 2007-11-22 Bausch & Lomb Incorporated Accommodative intraocular lens having defined axial compression characteristics
US20080046077A1 (en) 2006-08-15 2008-02-21 C&C Vision International Limited Multiocular Intraocular Lens Systems
US20100004742A1 (en) 2006-08-15 2010-01-07 C7C Vision International Limited Multiocular Intraocular Lens System
US20080051886A1 (en) 2006-08-24 2008-02-28 Lin J T Method and device for vision correction via dual-optics accommodating intraocular lens
GB0618262D0 (en) 2006-09-16 2006-10-25 Khoury Elie Accommodative intra-ocular lens
ES2373566T3 (es) 2006-12-13 2012-02-06 Akkolens International B.V. Lente intraocular acomodativa con corrección variable.
WO2008079671A1 (en) 2006-12-22 2008-07-03 Bausch & Lomb Incorporated Multi-element accommodative intraocular lens
EP2124822B1 (en) 2006-12-22 2019-02-20 AMO Groningen B.V. Accommodating intraocular lens, lens system and frame therefor
JP5207626B2 (ja) * 2006-12-26 2013-06-12 東レ・ダウコーニング株式会社 シリコーンゴム層と異種ゴム層からなるゴム積層体用加熱硬化性シリコーンゴム組成物、ゴム積層体およびその製造方法
WO2008083283A2 (en) 2006-12-29 2008-07-10 Advanced Medical Optics, Inc. Multifocal accommodating intraocular lens
US7713299B2 (en) 2006-12-29 2010-05-11 Abbott Medical Optics Inc. Haptic for accommodating intraocular lens
US8608799B2 (en) 2007-01-24 2013-12-17 Tekia, Inc. Umbrella-shaped accommodating artificial ocular lens (AAOL) device
WO2008097915A1 (en) 2007-02-02 2008-08-14 Key Medical Technologies, Inc. Interfacial refraction accommodating lens (iral)
US8034106B2 (en) 2007-02-02 2011-10-11 Adoptics Ag Interfacial refraction accommodating lens (IRAL)
US20080306587A1 (en) 2007-02-21 2008-12-11 Jingjong Your Lens Material and Methods of Curing with UV Light
EP2112932B1 (en) 2007-02-21 2014-12-17 PowerVision, Inc. Polymeric materials suitable for ophthalmic devices and methods of manufacture
US7986465B1 (en) 2007-03-01 2011-07-26 Rhevision Technology, Inc. Systems and methods for effecting zoom and focus using fluidic adaptive lenses
DE602008002904D1 (de) 2007-03-05 2010-11-18 Nulens Ltd Einheitlich akkommodierende intraokularlinsen (aiols) und diskrete basiselemente zur verwendung damit
US7753953B1 (en) 2007-03-30 2010-07-13 Kingman Yee Accommodating intraocular lens system
US8314927B2 (en) 2007-07-23 2012-11-20 Powervision, Inc. Systems and methods for testing intraocular lenses
AU2008279167B2 (en) 2007-07-23 2014-10-09 Alcon Inc. Post-implant lens power modification
US8968396B2 (en) 2007-07-23 2015-03-03 Powervision, Inc. Intraocular lens delivery systems and methods of use
WO2009015161A2 (en) 2007-07-23 2009-01-29 Powervision, Inc. Lens material with uv initiator and uv absorber and methods of curing with uv light
CA2696450C (en) 2007-07-23 2016-02-16 Terah Whiting Smiley Lens delivery system
JP5346022B2 (ja) 2007-07-23 2013-11-20 パワーヴィジョン・インコーポレーテッド 調節眼内レンズおよび使用方法
CA2852714C (en) 2007-08-13 2016-10-04 Garth T. Webb Inflatable intra ocular lens/lens retainer
US8377124B2 (en) 2007-10-02 2013-02-19 Novartis Ag Two-element system to provide an ease of accommodation with variable-spherical aberration control
JP5470256B2 (ja) 2007-10-15 2014-04-16 アッコレンズ インターナショナル ビー．ヴイ． 順応性眼内レンズおよび順応性眼内レンズ・システム
BRPI0820209A2 (pt) 2007-11-14 2015-06-16 Alcon Inc Lente intraocular
US9156949B2 (en) 2007-12-21 2015-10-13 Abbott Medical Optics Inc. Silicone containing polymeric materials
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
WO2009088448A2 (en) 2008-01-03 2009-07-16 Forsight Labs, Llc Intraocular, accomodating lens and methods of use
US20090198326A1 (en) 2008-01-31 2009-08-06 Medennium Inc. Accommodative intraocular lens system
US7998198B2 (en) 2008-02-07 2011-08-16 Novartis Ag Accommodative IOL with dynamic spherical aberration
US8254034B1 (en) 2008-03-31 2012-08-28 Rhevision Technology, Inc. Fluidic adaptive lens with a lens membrane having suppressed fluid permeability
JP5276165B2 (ja) 2008-07-24 2013-08-28 ニューレンズ・リミテッド 調節式眼内レンズ（ａｉｏｌ）カプセル
CN102186438A (zh) 2008-10-15 2011-09-14 爱尔康公司 调节性眼内透镜
US20120232649A1 (en) 2008-11-20 2012-09-13 Insight Innovations, Llc Intraocular Lens Cell Migration Inhibition System
US10299913B2 (en) 2009-01-09 2019-05-28 Powervision, Inc. Accommodating intraocular lenses and methods of use
EP2384167A4 (en) 2009-01-09 2016-02-17 Powervision Inc INTRAOCULAR LENSES AND METHODS FOR TAKING INTO ACCOUNT CAPSULE DIMENSION VARIABILITY AND POST-IMPLANTATION CHANGES IN THE EYE
US8222360B2 (en) 2009-02-13 2012-07-17 Visiogen, Inc. Copolymers for intraocular lens systems
US8657878B2 (en) 2009-02-18 2014-02-25 Hoya Corporation Interfacial refraction accommodating lens (IRAL)
US20100211169A1 (en) 2009-02-19 2010-08-19 Daniel Walter Stanley Intraocular lens configured to offset optical effects caused by optic deformation
WO2010126591A1 (en) 2009-04-29 2010-11-04 Gobi Ramakrishnan Padmanabhan Configurations and methods to manufacture solar cell device with larger capture cross section and higher optical utilization efficiency
US8320049B2 (en) 2009-07-15 2012-11-27 The Penn State Research Foundation Tunable liquid gradient refractive index lens device
US20110029074A1 (en) 2009-08-03 2011-02-03 Abbott Medical Optics Inc. Fixation of ophthalmic implants
JP5894076B2 (ja) 2009-08-31 2016-03-23 パワーヴィジョン・インコーポレーテッド 水晶体嚢サイズ推定方法
US20110071628A1 (en) 2009-09-24 2011-03-24 Rainbow Medical Ltd. Accommodative intraocular lens
DE112010004191T5 (de) 2009-10-30 2012-11-22 Akkolens International B.V. Intraokulare Linsen für einen variablen Brennpunkt
ES2907929T3 (es) 2009-11-17 2022-04-27 Akkolens Int B V Lente intraocular acomodativa accionada por masa ciliar
WO2011062826A2 (en) 2009-11-17 2011-05-26 Lu Kenneth L Accommodating intraocular lens
US8357196B2 (en) 2009-11-18 2013-01-22 Abbott Medical Optics Inc. Mark for intraocular lenses
EP2506803A1 (en) 2009-12-04 2012-10-10 AcuFocus, Inc. Corneal implant for refractive correction
GB2476480B (en) 2009-12-22 2013-04-03 Marwan Ghabra Intraocular implant with a fixed and a pivoting lens
WO2011094139A1 (en) 2010-01-26 2011-08-04 Klein, David Accommodating intraocular lens
JP2013520291A (ja) 2010-02-23 2013-06-06 パワーヴィジョン・インコーポレーテッド 遠近調節型眼内レンズのための液体
US9034035B2 (en) 2010-03-16 2015-05-19 Mor Research Applications Ltd. Accommodating intraocular lens assembly
WO2011137191A1 (en) 2010-04-27 2011-11-03 Ramgopal Rao Accommodating intraocular lens device
US10736732B2 (en) 2010-06-21 2020-08-11 James Stuart Cumming Intraocular lens with longitudinally rigid plate haptic
RU2013103484A (ru) 2010-06-29 2014-08-10 Дзе Аризона Борд Оф Риджентс Он Бихаф Оф Дзе Юниверсити Оф Аризона Аккомодирующая интраокулярная линза из деформируемого материала
WO2012006616A2 (en) 2010-07-09 2012-01-12 Powervision, Inc. Intraocular lens delivery devices and methods of use
JP2013537457A (ja) 2010-08-15 2013-10-03 ニューレンズ・リミテッド 個別組立済みモノリシックａｉｏｌ集合体およびこれらを含むａｉｏｌアセンブリ
EP2670348B1 (en) 2011-02-03 2022-10-12 Akkolens International B.V. Haptic combinations for accommodating intraocular lenses
JP6009463B2 (ja) 2011-02-04 2016-10-19 フォーサイト・ビジョン６・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ６， Ｉｎｃ． 調節型眼内レンズ
US8867141B2 (en) 2011-03-18 2014-10-21 Johnson & Johnson Vision Care, Inc. Lens with multi-concave meniscus wall
EP3928744A1 (en) 2011-03-24 2021-12-29 Alcon Inc. Intraocular lens loading systems and methods of use
WO2012158773A2 (en) 2011-05-16 2012-11-22 Ico, Inc. Filling and implanting accommodative intraocular lenses
US8715345B2 (en) 2011-05-23 2014-05-06 California Institute Of Technology Accommodating intraocular lens
US8771347B2 (en) 2011-05-23 2014-07-08 California Institute Of Technology Accommodating intraocular lens
US20140227437A1 (en) * 2011-05-23 2014-08-14 California Institute Of Technology Accommodating intraocular lens
US9186243B2 (en) 2011-05-31 2015-11-17 Novartis Ag Accommodative intraocular lens and method of implantation
US8257827B1 (en) * 2011-06-02 2012-09-04 The Regents Of The University Of California Silicone composition and devices incorporating same
US8608800B2 (en) 2011-08-02 2013-12-17 Valdemar Portney Switchable diffractive accommodating lens
WO2013016804A1 (en) 2011-08-03 2013-02-07 Webb Garth T Negatively pressurized deformable lens
KR101866873B1 (ko) 2011-08-09 2018-06-14 삼성전자주식회사 곡률 조절 소자 및 방법
JP5594262B2 (ja) * 2011-08-29 2014-09-24 信越化学工業株式会社 液状付加硬化型フロロシリコーンゴム組成物及びその成形品
US20130110234A1 (en) 2011-10-28 2013-05-02 Lauren DeVita Dual optic accommodating iol with low refractive index gap material
US10433949B2 (en) 2011-11-08 2019-10-08 Powervision, Inc. Accommodating intraocular lenses
CN107753151B (zh) 2011-11-08 2020-12-15 爱尔康公司 可调节人工晶状体及使用方法
US9364319B2 (en) 2012-09-25 2016-06-14 Valdemar Portney Refractive-diffractive switchable optical element
WO2013112589A1 (en) 2012-01-24 2013-08-01 Regents Of The University Of Colorado Modular intraocular lens designs and methods
US10028824B2 (en) 2012-01-24 2018-07-24 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
US9364316B1 (en) 2012-01-24 2016-06-14 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
US10080648B2 (en) 2012-01-24 2018-09-25 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
US8500806B1 (en) 2012-01-31 2013-08-06 Andrew F. Phillips Accommodating intraocular lens
US8900300B1 (en) 2012-02-22 2014-12-02 Omega Ophthalmics Llc Prosthetic capsular bag and method of inserting the same
CA2865954C (en) 2012-03-21 2021-10-05 Powervision, Inc. Intraocular lens delivery systems and methods of use
WO2013166068A1 (en) 2012-04-30 2013-11-07 Lensgen, Inc. Method and system for adjusting the refractive power of an implanted intraocular lens
US9084674B2 (en) 2012-05-02 2015-07-21 Abbott Medical Optics Inc. Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity
US9427312B2 (en) 2012-05-25 2016-08-30 California Institute Of Technology Accommodating intraocular composite lens and related methods
JP5872964B2 (ja) * 2012-05-29 2016-03-01 東レ・ダウコーニング株式会社 導電性室温硬化型フルオロシリコーンゴム組成物
FR2992215B1 (fr) 2012-06-21 2014-10-31 Oreal Composition cosmetique anhydre comprenant une huile, des particules d'aerogel de silice hydrophobe, un actif hydrophile et au moins un agent tensioactif
JP5803845B2 (ja) * 2012-08-22 2015-11-04 信越化学工業株式会社 付加硬化型フロロシリコーンゴム組成物
DE102012016893A1 (de) 2012-08-24 2014-05-15 Be Innovative Gmbh Intraokularlinse, insbesondere Kapselsackintraokularlinse
DE102012016892A1 (de) 2012-08-24 2014-02-27 Be Innovative Gmbh Intraokularlinse, insbesondere Ziliarintraokularlinse
US9622855B2 (en) 2012-10-08 2017-04-18 Valdemar Portney Remote multifocal to monofocal optic conversion
US20140107459A1 (en) 2012-10-11 2014-04-17 Alcon Research, Ltd. Devices, systems, and methods for intraocular measurements
US9433497B2 (en) 2012-10-19 2016-09-06 1Co, Inc. Systems and methods for customizing adjustable intraocular lenses
US20140121768A1 (en) 2012-10-31 2014-05-01 Novartis Ag Accommodating intraocular lens with ciliary body activation
US20140135917A1 (en) 2012-11-13 2014-05-15 Vision Solutions Technologies, Inc. Multi-focus intraocular prosthesis
WO2014099345A1 (en) 2012-12-18 2014-06-26 Novartis Ag Presbyopia-correcting iol using curvature change of an air chamber
US20140180406A1 (en) 2012-12-21 2014-06-26 Novartis Ag Accommodating intraocular lens
US9186244B2 (en) 2012-12-21 2015-11-17 Lensgen, Inc. Accommodating intraocular lens
RU2651088C2 (ru) 2012-12-21 2018-04-18 Новартис Аг Аккомодационная интраокулярная линза с изменяемой кривизной
EP2908776A4 (en) 2012-12-21 2015-11-18 Novartis Ag ACCOMMODATIVE INTRAOCULAR LENS CHANGING CURVATURE
US20140180410A1 (en) 2012-12-21 2014-06-26 Novartis Ag Intraocular lens or lens system to provide monofocal vision at multiple pre-defined focal points
US20140180407A1 (en) 2012-12-26 2014-06-26 Rainbow Medical Ltd. Accommodative intraocular lens
US9925039B2 (en) 2012-12-26 2018-03-27 Rainbow Medical Ltd. Accommodative intraocular lens
US20140309734A1 (en) 2012-12-26 2014-10-16 Rainbow Medical Ltd. Accommodative intraocular lens
US9486311B2 (en) 2013-02-14 2016-11-08 Shifamed Holdings, Llc Hydrophilic AIOL with bonding
WO2014134302A1 (en) 2013-02-28 2014-09-04 Richard Honigsbaum Tensioning rings for anterior capsules and accommodative intraocular lenses for use therewith
US20140257478A1 (en) 2013-03-07 2014-09-11 Sean J. McCafferty Accommodating fluidic intraocular lens with flexible interior membrane
US20140257479A1 (en) 2013-03-11 2014-09-11 Sean J. McCafferty Refocusable intraocular lens with flexible aspherical surface
EP3785668A1 (en) 2013-03-15 2021-03-03 Alcon Inc. Intraocular lens storage and loading devices and methods of use
US10195018B2 (en) 2013-03-21 2019-02-05 Shifamed Holdings, Llc Accommodating intraocular lens
CN110946676B (zh) 2013-03-21 2023-02-17 施菲姆德控股有限责任公司 调节性人工晶状体
DE102014106374A1 (de) 2013-05-07 2014-11-13 Akkolens International B.V. Akkommodierende intraokulare Linse mit Sulcusfixierungshaptiken
EP4245257A3 (en) 2013-06-03 2023-12-20 Alcon Inc. Modular intraocular lens designs
CN113214651A (zh) * 2013-08-28 2021-08-06 杜邦东丽特殊材料株式会社 可固化有机硅组合物、其固化产物以及光学半导体器件
EP2851038A1 (en) 2013-09-24 2015-03-25 Consejo Superior De Investigaciones Cientificas Intraocular lens with accomodation capacity
JP6625975B2 (ja) 2013-11-01 2019-12-25 レンスゲン、インコーポレイテッド 調節性眼内レンズデバイス
WO2015066532A1 (en) 2013-11-01 2015-05-07 Daniel Brady Two-part accommodating intraocular lens device
JP6549576B2 (ja) * 2013-11-20 2019-07-24 ダウ シリコーンズ コーポレーション オルガノシロキサン組成物
US9326846B2 (en) 2013-12-20 2016-05-03 Novartis Ag Accommodating intraocular lens
US20150173892A1 (en) 2013-12-23 2015-06-25 Novartis Ag Accommodating intraocular lens
CA3184269A1 (en) 2014-02-18 2015-08-27 Alcon, Inc. Modular intraocular lens designs, tools and methods
CA2941015C (en) 2014-03-07 2019-11-12 Conexus Lens, Inc. Refocusable lens system with mutually-applanating internal surfaces
US9333072B2 (en) 2014-04-29 2016-05-10 Chukyo Medical Co., Inc. Intraocular lens
CA2952809C (en) 2014-06-19 2019-11-26 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
US10004596B2 (en) 2014-07-31 2018-06-26 Lensgen, Inc. Accommodating intraocular lens device
US20160051361A1 (en) 2014-08-21 2016-02-25 Emmetrope Incorporated Accommodating Intraocular Lens
JP6267832B2 (ja) 2014-08-26 2018-01-24 シファメド・ホールディングス・エルエルシー 調節式眼内レンズ
US10265163B2 (en) 2014-12-27 2019-04-23 Jitander Dudee Accommodating intraocular lens assembly
JP7002331B2 (ja) 2015-01-30 2022-01-20 クラービスタ メディカル，インコーポレイテッド 眼内挿入用に構成された装置
US9358103B1 (en) 2015-02-10 2016-06-07 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
CN107624057B (zh) 2015-02-16 2019-09-06 诺华股份有限公司 具有可膨胀***储器的变曲率型可调节眼内晶状体
AU2015384792B2 (en) 2015-03-03 2020-09-03 Alcon Inc. Dual optic, curvature changing accommodative IOL
US20160287380A1 (en) 2015-03-30 2016-10-06 Wendian Shi Fluid-filled implantable structures with internal surface-modifying components and related methods
CN107635511A (zh) 2015-06-10 2018-01-26 力景公司 人工晶状体材料和组分
CA3002085A1 (en) 2015-11-04 2017-05-11 The Regents Of The University Of Colorado, A Body Corporate Modular intraocular lens designs, tools and methods
EP3884905A1 (en) 2015-11-06 2021-09-29 Alcon Inc. Ccommodating intraocular lenses
ES2617579B1 (es) 2015-11-16 2018-04-10 Lens Undergone Zonula Global, S.L. Lente intraocular acomodativa mejorada
EP4375066A3 (en) 2015-11-18 2024-07-17 Shifamed Holdings, LLC Multi-piece accommodating intraocular lens
WO2017096087A1 (en) 2015-12-01 2017-06-08 Daniel Brady Accommodating intraocular lens device
US9931202B2 (en) 2016-03-08 2018-04-03 Novartis Ag Dual optic, curvature changing accommodative IOL having a fixed disaccommodated refractive state
US11045309B2 (en) 2016-05-05 2021-06-29 The Regents Of The University Of Colorado Intraocular lens designs for improved stability
WO2017205811A1 (en) 2016-05-27 2017-11-30 Thomas Silvestrini Lens oil having a narrow molecular weight distribution for intraocular lens devices
EP3463189B1 (en) 2016-06-06 2023-01-18 Omega Ophthalmics LLC Prosthetic capsular device
US10159566B2 (en) 2016-09-26 2018-12-25 Novartis Ag Heat tunable intraocular lens
AU2017345731B2 (en) 2016-10-21 2019-10-24 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
WO2018081595A1 (en) 2016-10-28 2018-05-03 Forsight Vision6, Inc. Accommodating intraocular lens and methods of implantation
US10350056B2 (en) 2016-12-23 2019-07-16 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
WO2018119408A1 (en) 2016-12-23 2018-06-28 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
EP3595583A2 (en) 2017-03-13 2020-01-22 Kejako Sa Accommodative lens device
US10918476B2 (en) 2017-03-30 2021-02-16 Verily Life Sciences Llc Electrowetting intraocular lens with isotonic aqueous phase
US11409134B2 (en) 2017-04-19 2022-08-09 Amo Groningen B.V. Electrowetting and photo curing for manufacturing of ophthalmic lenses
US11197752B2 (en) 2017-05-05 2021-12-14 Verily Life Sciences Llc Situ filling and sealing of electrowetting intraocular lenses
AU2018277037B2 (en) 2017-05-30 2024-04-18 Shifamed Holdings, Llc Surface treatments for accommodating intraocular lenses and associated methods and devices
AU2018279101B2 (en) 2017-06-07 2023-07-13 Shifamed Holdings, Llc Adjustable optical power intraocular lenses
US11382736B2 (en) 2017-06-27 2022-07-12 Alcon Inc. Injector, intraocular lens system, and related methods
US10716661B2 (en) 2017-07-17 2020-07-21 Verily Life Sciences Llc Accommodating intraocular lens with meniscus
US20200253723A1 (en) 2017-07-31 2020-08-13 Douglas Michael Ackermann Pupillary accommodating intraocular lens
US20190069989A1 (en) 2017-09-06 2019-03-07 Verily Life Sciences Llc Multipart electrowetting intraocular lens for in-situ assembly

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032502A (en) * 1975-10-10 1977-06-28 Dow Corning Corporation Organosiloxane compositions for liquid injection
US5236970A (en) * 1987-02-05 1993-08-17 Allergan, Inc. Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses
US5312860A (en) * 1992-09-10 1994-05-17 Shin-Etsu Chemical Co., Ltd. Heat-curable silicone rubber composition and cured product thereof
US20020071856A1 (en) * 2000-04-12 2002-06-13 Dillingham Keith Alfred Injectable intraocular accommodating lens
CN1422166A (zh) * 2000-04-12 2003-06-04 法马西雅格罗宁根股份有限公司 可注射的眼内透镜
US20100204787A1 (en) * 2009-02-10 2010-08-12 Stephen Van Noy Accommodative intraocular lens system
WO2010093548A1 (en) * 2009-02-10 2010-08-19 Alcon, Inc. Accommodative intraocular lens system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114712026A (zh) * 2022-05-12 2022-07-08 温州医科大学附属眼视光医院 一种构建全混浊型白内障动物模型的方法

Also Published As

Publication number Publication date
US20200369853A1 (en) 2020-11-26
US10647831B2 (en) 2020-05-12
EP3197462A1 (en) 2017-08-02
JP6754755B2 (ja) 2020-09-16
WO2016049059A1 (en) 2016-03-31
US20170247525A1 (en) 2017-08-31
JP2017531471A (ja) 2017-10-26
EP3197462A4 (en) 2018-05-30

Similar Documents

Publication Publication Date Title
CN106999507A (zh) 用于调节人工晶状体的聚合材料
US6432137B1 (en) High refractive index silicone for use in intraocular lenses
US6613343B2 (en) Injectable intraocular accommodating lens
US10526353B2 (en) Lens oil having a narrow molecular weight distribution for intraocular lens devices
CA2346186C (en) Injectable intraocular lens
US9339373B2 (en) Polymer compositions suitable for intraocular lenses and related methods
US7241009B2 (en) Crosslinking of silicones presence of functionalized silicones
US20020055778A1 (en) Injectable intraocular lens
JP2005534737A5 (zh)
AU2001263848B2 (en) Injectable intraocular lens
AU2001263848A1 (en) Injectable intraocular lens
AU766854B2 (en) Injectable intraocular lens
MXPA01003611A (en) Injectable intraocular lens

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1241712

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170801

WD01 Invention patent application deemed withdrawn after publication