CN106983908A - Specific planting body for long-term Anti-platelet therapy patient and preparation method thereof - Google Patents
Specific planting body for long-term Anti-platelet therapy patient and preparation method thereof Download PDFInfo
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- CN106983908A CN106983908A CN201710123649.6A CN201710123649A CN106983908A CN 106983908 A CN106983908 A CN 106983908A CN 201710123649 A CN201710123649 A CN 201710123649A CN 106983908 A CN106983908 A CN 106983908A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of specific planting body for long-term Anti-platelet therapy patient, the implant surface is on titanium surface by poly-dopamine coating method of modifying, and grafting functional promotees platelet activation molecules.Beneficial effects of the present invention：The titanium surface that poly-dopamine coating is modified will be grafted to the functional molecular for promoting platelet activation aggregation by poly-dopamine coating, obtained planting body has the effect for promoting platelet activation, and then in the operation that tooth is repaired in plantation, making the amount of bleeding of long-term Anti-platelet therapy patient reduces；The similar PRP effects that the activated blood platelet of aggregation can be produced simultaneously, osteogenic action is promoted with potential.So as to improve the success rate and security that tooth is repaired in plantation, and plantation can also be carried out safely without being discontinued repairs tooth, be particularly suitable for use in the cardiovascular and cerebrovascular patient of long-term Anti-platelet therapy, and on the other hand, present invention also offers the method for specifically making the planting body.
Description
Technical field
The present invention relates to dentistry implant technical field, it particularly relates to which one kind is controlled for long-term antiplatelet drug
The method treated the specific planting body of patient and make the implant surface.
Background technology
China's cardiovascular patient is counted according to update and there are about 2.9 hundred million, and oral anti-diabetic agent thing is for angiocarpy
The prevention and treatment of disease is significant.The functions such as attractive in appearance caused by defect of dentition, dentition defect, chewing, voice, digestion
Exception, force patient actively seek oral restoration treatment.Increasing person in middle and old age's cardiovascular disease with dentition defect is artificial
Improve the quality of living, absence of tooth is repaired in selection plantation.Plantation repair in recent years due to plurality of advantages such as：Adjacent teeth is damaged
Similar natural teeth of true to nature, morphological function small, attractive in appearance etc. is widely used in repairing defect of dentition.For Long-term Oral antiplatelet drug
The tooth-planting surgical operation of thing patient is a difficult point of current Oral and Maxillofacial Surgery because its exist it is postoperative uncontrollable in art
Bleeding risk, and disable antiplatelet drug have induce cardiovascular and cerebrovascular acute disease risk.According to operative hemorrhage risk not
Together, various invasive operations and surgical operation are divided into very high-risk, high-risk, middle danger, low danger and very low 5 classes of endangering, wherein thinking mouth
Chamber surgical operation is high-risk bleeding risk.
Poly-dopamine coating is a kind of method of common functionalizing material surface modification.Due to simple to operate, safety
Property it is high, the surface modifying method of biomaterial is widely used as the advantages of the grafting for being easy to related group.Using dopamine in alkali
The hydrophily of material surface can be improved with the characteristic of auto polymerization in property solution.The poly-dopamine coating structure of formation is stable,
Cytotoxicity is low, with good biocompatibility.This seminar early-stage Study poly-dopamine coating modified cells creep plate substrate
On hematoblastic adhesive activating influence, it was demonstrated that this kind of method of modifying is safe and reliable.
Adenosine diphosphate (ADP) is a kind of endogenous material discharged from platelet dense-granules, can by with blood platelet
Two kinds of adp receptors of film are combined, and induce platelet activation aggregation.It is also simultaneously clinically conventional antiplatelet drug clopidogrel
Action target spot.Fibrinogen can be combined with platelet membrane acceptor GPIIa/IIIb, cause platelet aggregation.It is by
A α, B β, tri- couples of γ are different, and polypeptide chain is constituted, and intermolecular and intramolecule is connected with disulfide bond.Blood platelet is pierced by material
When swashing, signal acts on the intracellular part of platelet surface receptors first, then causes the extracellular region structure change of this receptor, enters
And binding fiber proteinogen.The other end of fibrinogen combines the blood platelet closed on again, causes hematoblastic aggregation.Fiber egg
The white former and further activation signal transmission system of hematoblastic combination, waits signaling molecule to be raised to cytoskeleton, acts on cell
Skeleton, causes its re-assemble, causes platelet activation to be assembled.
Long-term Anti-platelet therapy patient can just be faced with high-risk bleeding wind during tooth is repaired in plantation
Danger, in order to successfully plant reparation tooth, it has to which selection cuts out antiplatelet drug to avoid bleeding risk, and treats
During be difficult to find that a suitable time point to cut out medicine again therefore, how to allow long-term antiplatelet drug
Thing, which treats patient, can plant a technological difficulties in repairing tooth as oral surgery in the state of not being discontinued.
The problem of in correlation technique, effective solution is not yet proposed at present.
The content of the invention
For the above-mentioned technical problem in correlation technique, the present invention proposes a kind of for long-term Anti-platelet therapy trouble
The specific planting body of person, can make long-term Anti-platelet therapy patient to plant reparation tooth in the state of not being discontinued
Tooth, substantially increases the success rate that tooth is repaired in plantation, also, present invention also offers a kind of side for making the planting body
Method.
To realize above-mentioned technical purpose, the technical proposal of the invention is realized in this way：
A kind of specific planting body for long-term Anti-platelet therapy patient, the implant surface applies for poly-dopamine
The titanium surface of layer modification, the titanium surface of the poly-dopamine coating modification also has the functional molecular for promoting platelet activation aggregation
Modified coatings.
Further, the functional molecular modified coatings are adenosine diphosphate (ADP) modified coatings.
Further, the functional molecular modified coatings are fibrinogen modified coatings.
Further, the functional molecular modified coatings are adenosine diphosphate (ADP) and fibrinogen mixing modified coatings.
According to another aspect of the present invention there is provided a kind of method for making above-mentioned implant surface, poly-dopamine is utilized
Coating modifies the titanium surface of the specific planting body, and is further applied with the functional molecular for promoting platelet activation aggregation
The layer modification titanium surface.
Further, described functional molecular is adenosine diphosphate (ADP).
Further, described functional molecular is fibrinogen.
Further, described functional molecular is adenosine diphosphate (ADP) and fibrinogen.
Beneficial effects of the present invention：By poly-dopamine coating by with the functional molecular for promoting platelet activation aggregation
The titanium surface of poly-dopamine coating modification is grafted to, obtained planting body has the effect for promoting platelet activation aggregation, and then
In the operation that tooth is repaired in plantation, making the amount of bleeding of long-term Anti-platelet therapy patient reduces, and improves plantation and repairs tooth
The success rate and security of tooth, while the similar PRP that the activated blood platelet of aggregation can be produced（Platelet rich plasma,
Platelet rich plasma）Effect, osteogenic action is promoted with potential.Plantation, which can also be safely carried out, without being discontinued repairs tooth
Tooth, the cardiovascular and cerebrovascular patient for the long-term Anti-platelet therapy that is particularly suitable for use in, on the other hand, present invention also offers specific
The making planting body method.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to institute in embodiment
The accompanying drawing needed to use is briefly described.
Fig. 1 is the kind with adenosine diphosphate (ADP) and fibrinogen mixing modified coatings described according to embodiments of the present invention
The preparation flow figure on implant surface；
Fig. 2 is titanium group described according to embodiments of the present invention, ADP groups, FIB groups, ADP and FIB mixed grafting groups surface XPS figures
Spectrum；
Fig. 3 is titanium group described according to embodiments of the present invention, ADP groups, FIB groups, ADP and FIB mixed grafting group surface contact angles
Spend column diagram；
Fig. 4 A-4H are blood platelet patterns under ESEM described according to embodiments of the present invention；
Fig. 5 is titanium group described according to embodiments of the present invention, ADP groups, FIB groups, ADP and FIB mixed grafting groups surface blood platelet
Adhesive capacity column diagram；
Fig. 6 is healthy hematoblastic aggregation activation situation described according to embodiments of the present invention；
Fig. 7 is the hematoblastic aggregation activation situation of case described according to embodiments of the present invention；
Fig. 8 is cell in vitro proliferation experiment result column diagram described according to embodiments of the present invention.
Embodiment
Technical scheme is clearly and completely described below in conjunction with accompanying drawing, the embodiment should
It is not understood as in order to which the present invention is furture elucidated without to limit the present invention.Experimental method described in following embodiments, such as without
Specified otherwise, is conventional method；The reagent and biomaterial are commercially obtained unless otherwise specified.
Embodiment one：The preparation process of material
As shown in Figure 1.
1.1 poly-dopamine coating surfaces are modified
Titanium sheet is placed in 24 orifice plates, adds after the sealing of 2mg/mL dopamine solutions 1mL, Parafilm sealed membrane, soaks 24h.Make
The unreacted dopamine particle of removal is cleaned with instrument is cleaned by ultrasonic, is the titanium surface of poly-dopamine coating modification（Ti+DOP）.
The modification of 1.2 ADP coatings, the modification of FIB coatings
Mg/ml ADP solution 1ml, 1mg/ml FIB solution 1ml. Parafilm are added in the titanium surface that poly-dopamine is modified
24h is reacted after sealing membrane closure.Obtain Ti+DOP+ADP, Ti+DOP+FIB.
1.3 ADP mixes modification with FIB
Mg/ml ADP solution and 1mg/ml FIB solution (1 are added in the titanium surface that poly-dopamine is modified：1).Parafilm is sealed
24h is reacted after membrana oralis closing.As Ti+DOP+ADP+FIB.
Embodiment two：Material characterization is analyzed
2.1 X-ray photoelectron spectroscopic analysis（XPS）
Using Axis Ultra Multifunctional imaging electron spectrometers, plate target is aluminium target, and energy is 1486.7eV, sample vacuum chamber
Degree remains 6.7x10-7Pa, and photoelectron incidence angle is 20o.Calibrated at C1s peaks through 284.8eV.Material surface before characterizing
Drying.With Casa XPS software analysis processing datas.
Experimental result is as shown in Fig. 2 pure titanium group material surface is mainly Ti absworption peaks.The material list after DOPA is amine-modified
The Ti peaks in face disappear, and have apparent N element absworption peak, are due to contain amino in dopamine（-NH2）, can be proved with this
Dopamine has succeeded coating to titanium surface；Fibrinogen group is visible on the basis of dopamine, and the enhancing of N absworption peaks, and S absorb
Peak occurs.Due to containing substantial amounts of amino, and disulfide bond in fibrin original structure.Prove that fibrinogen successfully connects
Branch；The enhancing at N peaks, has proved the grafting success of fibrinogen；Adenosine diphosphate (ADP) group has P absworption peaks to occur, and compared to
Dopamine group N absworption peaks also increased.Prove that adenosine diphosphate (ADP) is successfully grafted.Fibrinogen is mixed with adenosine diphosphate (ADP)
Visible N, P, S absworption peak of grafting group occurs, and P absworption peaks have declined compared to fibrinogen group, and N absworption peaks are between fiber egg
It is due to that material is covered to the part on surface, it was demonstrated that fibrinogen and Adenosine diphosphate between white original group and adenosine diphosphate (ADP) group
Successful grafting of the glycosides in material surface.
2.2 static contact angles are detected
The contact angle between sample and water is measured in sessile drop method under room temperature condition, the test liquid used is distilled water.Respectively
Ti, Ti+DOP, Ti+DOP+ADP, Ti+DOP+FIB and Ti+DOP+ADP+FIB sample are detected, with 2 μ L distilled waters drop after the drying
Material surface, it is stable after survey its static contact angle.Each sample measures 3 points, and the size of the contact angle of material surface is characterized
The hydrophilicity of material surface.
Experimental result is as shown in figure 3, implant surface property has a certain impact to the adhesion tool of Gegenbaur's cell.Study table
Bright hydrophilic surface can adjust the function of many cells, such as blood platelet, Gegenbaur's cell, promote the combination of early stage and planting body.
Titanium group surface contact angle average value is about 72 °.It is presented as the property of relative hydrophobic.Poly-dopamine painting is carried out to titanium material surface
After layer modification, the contact angle average value of material surface is down to 29 °.Caused by dopamine containing substantial amounts of hydrophily machine group.
After adenosine diphosphate (ADP) is grafted, the contact angle average value of material surface is about 26 °.Material list after fibrinogen modification
The contact angle average value in face is 76 °.Adenosine diphosphate (ADP) and the material surface contact angle average value after fibrinogen mixed grafting
For 52 °.
Embodiment three：Blood platelet related experiment
3.1 prepare Platelet-rich plasm (platelet-rich plasma, PRP)
Collection does not take healthy volunteer's venous blood 10ml of antiplatelet drug as a control group（Totally 1 group）, long-term taking resist
The Venous Blood 10ml of more than 1 year stable disease of antiplatelet drug is used as case group（Totally 3 groups）.Laboratory prepares blood platelet
Suspension.The Venous Blood sample of more than 1 year stable disease of healthy volunteer's venous blood and long-term taking antiplatelet drug
Gather from An Zhen hospital.
3.2 FE-SEM are observed（FE-SEM is field emission scanning electron microscope）
Respectively by the healthy control group of 100 μ L platelet suspensions, four are added to patient cases' group for taking antiplatelet drug
Group sample surfaces, are incubated 30min, after 2.5% glutaraldehyde fixed sample, Gradient elution using ethanol；Room temperature.Analyzed using FE-SEM
The hematoblastic pattern in Ti, Ti+DOP, Ti+DOP+ADP, Ti+DOP+FIB and Ti+DOP+ADP+FIB surface.
Experimental result is as shown in figure 4, wherein A figures are control group, and B figures are experimental group, and in low power Microscopic observation, titanium surface is glued
Attached blood platelet amount is seldom.The modified material surface platelet adhesion reaction amount increase in surface.ADP and FIB mixes the blood of grafting group
Platelet adhesive capacity many and independent grafting group relatively.
3.3 lactic dehydrogenase（LDH）Determine platelet adhesion reaction amount
The healthy control group of 200 μ L rich platelet suspension is taken respectively, is added to patient cases' group for taking antiplatelet drug
Four groups of sample surfaces, which are added, is incubated 30min in sample, add 0.1%Triton solution cracking 0.5h, use LDH kit measurements
The content of lactic dehydrogenase.
Experimental result by the modified material surface platelet adhesion reaction amount in surface as shown in figure 5, be higher than titanium group.
3.4 immunofluorescence dyeing
The healthy control group of 300 μ platelet suspensions is taken respectively, and four groups are added to patient cases' group for taking antiplatelet drug
Sample surfaces are added in sample, and 30min is incubated at room temperature, and 4% paraformaldehyde fixes 30min, and 0.1% Triton-100 is molten
Liquid cell lysis 30min.Antibody CD41-FITC and CD62P-PE are separately added into, is incubated.Fluorescence microscopy Microscopic observation blood platelet exists
The fluorescence distribution of material surface.
Experimental result is as shown in Figure 6 and Figure 7.
Respectively with the antibody CD41-FITC with fluorescence（Green glow）And CD62P-PE（Feux rouges）With the CD41 on platelet membrane by
Body and CD62P acceptors are combined, observation ADP groups, FIB groups, ADP and FIB mixed grafting group material surfaces under immunofluorescence microscopy
Hematoblastic fluorescence intensity will be significantly higher than titanium group.Show there is substantial amounts of blood platelet to be active.
Example IV：Cell in vitro proliferation experiment
It is placed in after the material for preparing laboratory in super-clean bench, alcohol disinfecting in sterile 24 porocyte culture plates, by 3 ×
104cells/ml concentration inoculation hMSC（Mesenchymal stem cells MSCs）, respectively at 1d, 3d, the 5d after inoculation, use CCK8 reagents
Box detects hMSC proliferative conditions.
Experimental result is as shown in Figure 8.
HMSC is with the growth of incubation time, and cell is in the equal continuation increase of all sample surfaces, the table of functions
Face has good cell compatibility.
In summary, the specificity for being used for long-term Anti-platelet therapy patient provided according to the present patent application is planted
Body, has the function of promoting platelet activation aggregation, with good hydrophily, can adjust the function of many cells, such as really
Blood platelet, Gegenbaur's cell, promote the combination of early stage and planting body, and with good cell compatibility, will not be brought to patient
Others negative effect.
Claims (8)
1. a kind of specific planting body for long-term Anti-platelet therapy patient, it is characterised in that the plantation body surface
Face is the titanium surface that poly-dopamine coating is modified, and also there is rush platelet activation to gather on the titanium surface of the poly-dopamine coating modification
The functional molecular modified coatings of collection.
2. a kind of specific planting body for long-term Anti-platelet therapy patient according to claim 1, it is special
Levy and be, the functional molecular modified coatings are adenosine diphosphate (ADP) modified coatings.
3. a kind of specific planting body for long-term Anti-platelet therapy patient according to claim 1, it is special
Levy and be, the functional molecular modified coatings are fibrinogen modified coatings.
4. a kind of specific planting body for long-term Anti-platelet therapy patient according to claim 1, it is special
Levy and be, the functional molecular modified coatings are adenosine diphosphate (ADP) and fibrinogen mixing modified coatings.
5. a kind of method for making the specific planting body for long-term Anti-platelet therapy patient, it is characterised in that profit
The titanium surface of the specific planting body is modified with poly-dopamine coating, and further with the work(for promoting platelet activation aggregation
Can the property molecular coatings modification titanium surface.
6. the method according to claim 5 for making implant surface, it is characterised in that described functional molecular is two
AMP.
7. the method according to claim 5 for making implant surface, it is characterised in that described functional molecular is fibre
Fibrillarin is former.
8. the method according to claim 5 for making implant surface, it is characterised in that described functional molecular is two
AMP and fibrinogen.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737814A (en) * | 2022-10-26 | 2023-03-07 | 中国科学院大学 | Antiplatelet medicament, preparation method thereof and antiplatelet medicament capturing agent |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791437A (en) * | 2003-05-16 | 2006-06-21 | 布卢薄膜有限责任公司 | Medical implants comprising biocompatible coatings |
| WO2008064487A1 (en) * | 2006-11-30 | 2008-06-05 | Bio Syntech Canada Inc. | Method for in situ solidification of blood-polymer compositions for regenerative medicine and cartilage repair applications |
| KR101495449B1 (en) * | 2013-11-12 | 2015-02-23 | 전북대학교산학협력단 | Method for manufacturing a platelet patch |
| CN105339017A (en) * | 2013-05-02 | 2016-02-17 | 奥齿泰有限责任公司 | Method for treating surface of implant |
-
2017
- 2017-03-03 CN CN201710123649.6A patent/CN106983908A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791437A (en) * | 2003-05-16 | 2006-06-21 | 布卢薄膜有限责任公司 | Medical implants comprising biocompatible coatings |
| WO2008064487A1 (en) * | 2006-11-30 | 2008-06-05 | Bio Syntech Canada Inc. | Method for in situ solidification of blood-polymer compositions for regenerative medicine and cartilage repair applications |
| CN105339017A (en) * | 2013-05-02 | 2016-02-17 | 奥齿泰有限责任公司 | Method for treating surface of implant |
| KR101495449B1 (en) * | 2013-11-12 | 2015-02-23 | 전북대학교산학협력단 | Method for manufacturing a platelet patch |
Non-Patent Citations (4)
| Title |
|---|
| TAGUCHI, KAZUAKI等: "Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen gamma-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model", 《JOURNAL OF PHARMACEUTICAL SCIENCES》 * |
| 张冉冉等: "基于聚多巴胺的材料表面修饰对二磷酸腺苷促血小板聚集功能的影响", 《口腔颌面修复学杂志》 * |
| 张庆宪主编: "《常用新药精汇手册》", 28 February 2009, 河南科学技术出版社 * |
| 曹献英主编: "《应用生理学》", 30 September 2015, 中国科学技术大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737814A (en) * | 2022-10-26 | 2023-03-07 | 中国科学院大学 | Antiplatelet medicament, preparation method thereof and antiplatelet medicament capturing agent |
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Application publication date: 20170728 |
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