CN106975100B - A kind of nanocomposite and its preparation method and application of cerium oxide/mesoporous silicon - Google Patents
A kind of nanocomposite and its preparation method and application of cerium oxide/mesoporous silicon Download PDFInfo
- Publication number
- CN106975100B CN106975100B CN201610027779.5A CN201610027779A CN106975100B CN 106975100 B CN106975100 B CN 106975100B CN 201610027779 A CN201610027779 A CN 201610027779A CN 106975100 B CN106975100 B CN 106975100B
- Authority
- CN
- China
- Prior art keywords
- cerium oxide
- mesoporous silicon
- nanocomposite
- ligand
- nanocrystal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
Abstract
The present invention relates to a kind of nanocomposite of cerium oxide/mesoporous silicon, the cerium oxide nanocrystal of cerium oxide nanocrystal and amido modified nanometer particle comprising ligand conversion, ligand conversion is modified in the surface of amido modified nanometer particle；The mass ratio of cerium oxide nanocrystal that ligand is converted and amido modified nanometer particle is 1~20；The cerium oxide nanocrystal of ligand conversion carries out ligand conversion using 2- bromo acid.The invention further relates to the preparation method of cerium oxide/mesoporous silicon nanocomposite and its applications in wound healing or tissue repair.The active oxygen radical that the composite material can balance the surface of a wound is horizontal, reduces level of inflammation, plays adhesive effect using nanometer bridge effect；And preparation reaction system is mild, and condition is controllable, and prepared material all has good biocompatibility, has good clinical conversion possibility.
Description
Technical field
The present invention relates to cerium oxide/mesoporous silicon field of composite material preparation, and in particular to a kind of cerium oxide/mesoporous silicon is received
Nano composite material and its preparation method and application.
Background technique
Chronic refractory skin trauma brings pain to patient, while bringing heavy burden to health system.By
There is very high disability rate and lethality in chronic refractory sexual trauma, need to develop new treatment means and make up existing therapies means
Deficiency.According to statistics, only in the chronic refractory trauma patient in the U.S. just about 6,500,000, it is used for chronic refractory sexual trauma every year
Cost just more than 25,000,000,000 dollars, and it is contemplated that, with obesity, the disease incidence of diabetes is higher and higher, this number
It will also continue to increase.
To the afunction of various molecular cells signal necessary to proper wound agglutination or to be interfered be shape
At the basic reason of chronic refractory sexual trauma.In addition, the microorganisms intrusion surface of a wound in external environment also results in chronic inflammation
Disease reaction, is more unfavorable for the healing of the surface of a wound.It has been reported that chronic inflammatory reaction is certain related to the generation of tumour presence
Property.Other than chronic refractory sexual trauma, promote by liver, kidney, lung, the healing of the internal organ such as heart wound caused by operation and organ
The recovery of function is also to work as previous more intractable difficult medical problem.For by liver, kidney, lung, the internal organ such as heart are caused by operation
Wound, operation stitching and polymer bonding agent are common at present and effective treatment means.But for liver, lung etc.
For soft connective tissue, operation stitching will cause certain organ injury.Polymer bonding agent is also because control intracorporal polymerization
Or the condition of cross-linking reaction is excessively complicated and acts on the reasons such as limited in wet vivo environment and limits its scope of application.
The feature that moistens for certain internal organs softnesses and lead to many external internal factors of chronic refractory sexual trauma,
Nearest some basic research and preclinical study show that nanoparticle has in terms of promoting wound healing caused by a variety of causes
There are huge potentiality.A drop silicon nano is molten at room temperature for the research achievement discovery of Ludwik Leibler et al.
Liquid can generate quickly strong adhesive effect between two blocks of individual hydrogels.In animal skin wound and internal organ operation wound
Ludwik Leibler et al.'s the experimental results showed that, nano-particle solution consistent with result on the hydrogel on model
It can accelerate the healing of wound by a kind of so-called nanometer bridge effect.
But existing research the result shows that, due to lack glutathione, the endogenic antioxidant such as vitamin E so that
It is one of the reason of diabetes and age ageing etc. form chronic refractory sexual trauma that the raised reactive oxygen species of site of injury, which cannot be neutralized,.
Therefore, the healing for only accelerating wound by nanometer bridge effect in the prior art, does not balance site of injury with antioxidant
Reactive oxygen species, the effect of accelerating wound healing is unobvious.
Summary of the invention
The purpose of the present invention is overcoming defect in the prior art, a kind of nano combined material of cerium oxide/mesoporous silicon is provided
Material and its preparation method and application.
Technical solution provided by the invention is as follows:
A kind of nanocomposite of cerium oxide/mesoporous silicon, the cerium oxide nanocrystal and amido modified comprising ligand conversion
Nanometer particle, the cerium oxide nanocrystal of the described ligand conversion modifies in amido modified nanometer particle
Surface；The mass ratio of cerium oxide nanocrystal that ligand is converted and amido modified nanometer particle is 1~20；Described
The cerium oxide nanocrystal of ligand conversion carries out ligand conversion using 2- bromo acid.
The nanocomposite of above-mentioned cerium oxide/mesoporous silicon provided by the invention can balance the active oxygen radical of the surface of a wound
Level reduces level of inflammation, and plays adhesive effect using nanometer bridge effect.Firstly, nanometer particle has nanometer
Bridge effect can promote wound healing；Secondly, cerium oxide nanocrystal can balance the raised reactive oxygen species of site of injury, in turn
Reactive oxygen species are reduced to act on the oxidative damage of the cell membrane of periwound environment and protein, will neutralization activity oxygen cluster oxygen
It is nanocrystalline for wound repair to change cerium, can make up for it the deficiency of endogenous antioxidant.In order to by cerium oxide nanocrystal with stabilization
The form of covalent bond be connected to nanometer particle surface, ligand is carried out to cerium oxide nanocrystal first with 2- bromo acid
Conversion, then nanometer particle surface is carried out amido modified, be conducive between the two compound, finally make two kinds of materials
Performance is further promoted after compound.
Preferably, the partial size for the cerium oxide nanocrystal that the ligand is converted is 1~10nm, described is amido modified
The partial size of nanometer particle is 5~500nm.Cerium oxide nanocrystal and the affiliated particle size range of nanometer particle, are convenient for
Cerium oxide nanocrystal is uniform must to modify the composite material for obtaining pattern in the surface of nanometer particle and haveing excellent performance.
The present invention also provides a kind of preparation methods of the nanocomposite of cerium oxide/mesoporous silicon, include the following steps:
1) cerous acetate hydrate and oleyl amine are added in dimethylbenzene, 3~6h is reacted at 85 DEG C~95 DEG C, aging is sunk
It forms sediment, obtains cerium oxide nanocrystal；
2) to cerium oxide nanocrystal obtained in step 1), ligand conversion is carried out using 2- bromo acid, obtains ligand
The cerium oxide nanocrystal of conversion；
3) hexadecyltrimethylammonium chloride and triethanolamine be then dissolved in water, react 0.5 at 90 DEG C~100 DEG C~
5h, continuously adds ethyl orthosilicate and 3- aminopropyl triethoxysilane reacts 0.5~5h, is centrifuged, and washing obtains amido modified
Mesoporous silicon dioxide nano particle；
4) cerium oxide nanocrystal of ligand conversion and amido modified nanometer particle are added in ethyl alcohol, 45
DEG C~55 DEG C at react 8~15h, obtain cerium oxide/mesoporous silicon nanocomposite.
Using above-mentioned preparation method, cerium oxide/mesoporous silicon nanocomposite can be prepared, which can
Active oxygen radical by the cerium oxide nanocrystal balance surface of a wound is horizontal, reduces level of inflammation, and can utilize nanometer grain
The nanometer bridge effect of son plays adhesive effect, and therefore, the advantage of two kinds of materials mutually assists, so that cerium oxide/mesoporous silicon
The performance of nanocomposite further gets a promotion.
Preferably, the mass ratio of cerous acetate hydrate and oleyl amine is 1:7~9 in the step 1).
Preferably, hexadecyltrimethylammonium chloride, triethanolamine, ethyl orthosilicate and 3- ammonia in the step 3)
The feed ratio of propyl-triethoxysilicane are as follows: 1.5~2.5g:0.03~0.05g:1.4~1.6ml:0.14~0.16ml.
Preferably, ligand is converted in the step 4) cerium oxide nanocrystal and amido modified nanometer grain
The mass ratio of son is 1~20.By regulating and controlling mass ratio between the two, control in cerium oxide/mesoporous silicon nanocomposite
The content of the cerium oxide nanocrystal of ligand conversion, so that the cerium oxide nanocrystal of ligand conversion is easy to modify in amido modified Jie
Hole silicon nano surface, convenient for the regulation of pattern and the modification of cerium oxide nanocrystal.
Preferably, ligand conversion refers in the step 2), by cerium oxide nanocrystal obtained in step 1), 2- bromine
The in the mixed solvent for being added sequentially to chloroform and N-N dimethylformamide for isobutyric acid and citric acid stirs 20~30h.Ligand
Conversion is in order to which cerium oxide nanocrystal is connected to nanometer particle surface in the form of stable covalent bond.
Preferably, the mass ratio of the 2- bromo acid and cerium oxide nanocrystal are as follows: 20~60.
The present invention also provides a kind of application of the nanocomposite of cerium oxide/mesoporous silicon in wound healing.
Compared with the existing technology, the beneficial effects of the present invention are embodied in:
(1) cerium oxide/mesoporous silicon novel nanocomposite materials can balance the active oxygen radical level of the surface of a wound, reduce scorching
Disease is horizontal, plays the mechanism such as adhesive effect using nanometer bridge effect and promotes acute and chronic wound healing and tissue repair.
(2) it is mild that the present invention relates to reaction systems, and condition is controllable, and prepared material all has good bio-compatible
Property, there is good clinical conversion possibility.
Detailed description of the invention
Fig. 1 is the X-ray diffractogram of the cerium oxide nanocrystal of the ligand conversion in embodiment 1；
Fig. 2 is the transmission electron microscope photo of the cerium oxide nanocrystal of the ligand conversion in embodiment 1；
Fig. 3 is the transmission electron microscope photo of the amido modified nanometer particle in embodiment 1；
Fig. 4 is the transmission electron microscope photo of cerium oxide/mesoporous silicon nanocomposite in embodiment 1；
Fig. 5 is the scanning transmission electron microscope photo of cerium oxide/mesoporous silicon nanocomposite in embodiment 1；
Fig. 6 is the distribution diagram of element of cerium oxide/mesoporous silicon nanocomposite in embodiment 1；
Fig. 7 is the MTS cell activity quantitative analysis results of cerium oxide/mesoporous silicon nanocomposite in application examples
Figure；
Fig. 8 is that the different materials in the present invention handle SD rat trauma model Healing Rate, and wherein MSN-ceria is oxidation
Cerium/mesoporous silicon nanocomposite, MSN are nanometer particle, and Control is blank test；
Fig. 9 is the picture of the processing SD rat trauma model of the different materials in the present invention, and wherein MSN-ceria is oxidation
Cerium/mesoporous silicon nanocomposite, MSN are nanometer particle, and Control is blank test.
Specific embodiment
Cerium oxide of the present invention/nanometer composite material system is elaborated below with reference to specific embodiment and attached drawing
Application standby and its in promotion wound healing.
Embodiment 1
(1) synthesis of cerium oxide nanocrystal and ligand conversion: 0.4g cerous acetate hydrate and 3.2g oleyl amine are added to
It in 15ml dimethylbenzene, is stirred at room temperature 4 hours, hastens to rise to 90 degrees Celsius with the heating of 2 centigrade per minutes；By 1ml deionization
Water injection is into reaction system, and aging three hours, acetone precipitation, centrifugation obtained cerium oxide nanocrystal.The oxidation that synthesis is obtained
Cerium is nanocrystalline, 0.5g 2- bromo acid and 0.05g citric acid are added sequentially to 7.5ml chloroform and 7.5ml N, N- dimethyl
The in the mixed solvent of formamide stirs 24 hours to obtain the final product.
X-ray diffraction is carried out to the cerium oxide nanocrystal of obtained ligand conversion, as shown in Fig. 1；And ligand is turned
The cerium oxide nanocrystal changed carries out morphology characterization with transmission electron microscope, as shown in Figure 2.
(2) synthesis of amido modified mesoporous silicon dioxide nano particle: by 2g hexadecyltrimethylammonium chloride and
0.02g triethanolamine is added in 20ml deionized water, and stirring is warming up to 95 degrees Celsius, and ethyl orthosilicate 1.5ml and 150 is added
μ L 3- aminopropyl triethoxysilane is stirred to react 0.5~1h.Template is washed away by centrifugation and 1wt% sodium chloride methanol solution
Amido modified mesoporous silicon dioxide nano particle can be obtained in agent.
Transmission electron microscope morphology characterization, such as Fig. 3 are carried out to the amido modified nanometer particle being prepared
It is shown.
(3) synthesis of cerium oxide/mesoporous silicon nanocomposite: the concentration that 5ml ligand is converted is 0.6mM cerium oxide
The ethanol solution of the 0.5mg/ml of nanocrystalline ethanol solution and 1ml amido modified mesoporous silicon dioxide nano particle is taken the photograph 45
Family name's degree, which reacts 12 hours, can be obtained cerium oxide/mesoporous silicon nanocomposite.It is multiple to cerium oxide/mesoporous silicon nanometer is obtained
Condensation material carries out transmission electron microscope and scanning transmission electron microscope, and acquired results are as shown in Figures 4 and 5, cerium oxide/mesoporous
The diameter of the nanocomposite of silicon is 50~60nm；In addition elemental analysis has also been carried out, as shown in Figure 6, it is known that the ball of grey
Refer to that mesoporous silicon, white point refer to cerium oxide.
Embodiment 2
(1) 0.4g cerous acetate hydrate and 3.6g oleyl amine the synthesis of cerium oxide nanocrystal and ligand conversion: are added to two
It in toluene, is stirred at room temperature 6 hours, hastens to rise to 95 degrees Celsius with the heating of 2 centigrade per minutes；1ml deionized water is injected
Into the reaction system of inert gas shielding, aging three hours, acetone precipitation, centrifugation obtained cerium oxide nanocrystal.It will synthesize
To oxidation be that nanocrystalline, 0.5g 2- bromo acid and 0.05g citric acid are added sequentially to 7.5ml chloroform and 7.5ml N,
The in the mixed solvent of dinethylformamide stirs 24 hours to obtain the final product.
(2) synthesis of amido modified mesoporous silicon dioxide nano particle: by 2.4g hexadecyltrimethylammonium chloride and
0.05g triethanolamine is added in 20ml deionized water, and stirring is warming up to 95 degrees Celsius, and ethyl orthosilicate 1.4ml and 160 is added
μ L 3- aminopropyl triethoxysilane is stirred to react.Washing away template by centrifugation and 1wt% sodium chloride methanol solution can obtain
To amido modified mesoporous silicon dioxide nano particle.
(3) synthesis of cerium oxide/mesoporous silicon nanocomposite: the concentration that 8ml ligand is converted is 0.6mM cerium oxide
The 0.5mg/ml of nanocrystalline ethanol solution and 1ml amido modified mesoporous silicon dioxide nano particle 50 is taken the photograph in ethanol system
Family name's degree, which reacts 12 hours, can be obtained cerium oxide/mesoporous silicon nanocomposite.
Embodiment 3
(1) 0.4g cerous acetate hydrate and 2.8g oleyl amine the synthesis of cerium oxide nanocrystal and ligand conversion: are added to two
It in toluene, is stirred at room temperature 3 hours, hastens to rise to 88 degrees Celsius with the heating of 2 centigrade per minutes；1ml deionized water is injected
Into the reaction system of inert gas shielding, aging three hours, acetone precipitation, centrifugation obtained cerium oxide nanocrystal.It will synthesize
To oxidation be that nanocrystalline, 0.5g 2- bromo acid and 0.05g citric acid are added sequentially to 7.5ml chloroform and 7.5ml N,
The in the mixed solvent of dinethylformamide stirs 24 hours to obtain the final product.
(2) synthesis of amido modified mesoporous silicon dioxide nano particle: by 2g hexadecyltrimethylammonium chloride and
0.04g triethanolamine is added in 20ml deionized water, and stirring is warming up to 95 degrees Celsius, and ethyl orthosilicate 1.4ml and 160 is added
μ L 3- aminopropyl triethoxysilane is stirred to react.Template is washed away by centrifugation and 1wt% sodium chloride methanol solution
Obtain amido modified mesoporous silicon dioxide nano particle.
(3) synthesis of cerium oxide/mesoporous silicon nanocomposite: the concentration that 4ml ligand is converted is 0.6mM cerium oxide
The 0.5mg/ml of nanocrystalline ethanol solution and 1ml amido modified mesoporous silicon dioxide nano particle 60 is taken the photograph in ethanol system
Family name's degree, which reacts 12 hours, can be obtained cerium oxide/mesoporous silicon nanocomposite.
Application examples
Cerium oxide/mesoporous silicon nanocomposite promotes skin wound healing for SD rat
Biocompatibility in vitro evaluation: various concentration nanometer is investigated in selection human skin fibroblasts strain (HSF)
The biocompatibility in vitro of material and cerium oxide/mesoporous silicon nanocomposite.MTS cell activity quantitative analysis results are as schemed
Shown in 7, various concentration group cell survival rate 80% or more, shows nanometer material (MSN) and cerium oxide/mesoporous silicon
Nanocomposite (MSN-ceria) all have good biocompatibility in vitro.
The foundation and interpretation of result of skin trauma model: according to the dosage of 4ml/kg by 10wt% chloraldurate to SD
Rats by intraperitoneal injection anesthesia, rejects back hair, the wound of the full skin thickness of standardized 2 centimeter lengths at back.Rat is random
It is divided into 3 groups, every group 5.3 groups of rat back site of injury give blank (control), 50 μ L 10mg/ml nanometer grains respectively
Sub- water dispersion solution (MSN), 50 μ L 10mg/ml cerium oxide/mesoporous silicon nanocomposite water dispersion solution (MSN-
ceria).Each group wound length recovery situation is recorded at the specified time point.The reparation rate of wound is as shown in figure 8, Fig. 9 is rat
Back wound was first day and photo on the 9th.
Technical solution of the present invention and beneficial effect is described in detail in embodiment described above, it should be understood that with
Upper described is only specific embodiments of the present invention, be not intended to restrict the invention, all to be done in spirit of the invention
Any modification, supplement and equivalent replacement etc., should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of nanocomposite of cerium oxide/mesoporous silicon, which is characterized in that the cerium oxide nanocrystal and ammonia converted by ligand
The cerium oxide nanocrystal of the nanometer particle composition of base modification, the ligand conversion is modified in amido modified mesoporous silicon
The surface of nanoparticle；The mass ratio of cerium oxide nanocrystal that ligand is converted and amido modified nanometer particle into 1~
20；The cerium oxide nanocrystal of the ligand conversion carries out ligand conversion using 2- bromo acid.
2. the nanocomposite of cerium oxide/mesoporous silicon according to claim 1, which is characterized in that the ligand turns
The partial size of the cerium oxide nanocrystal changed is 1~10nm, the partial size of the amido modified nanometer particle is 5~
500nm。
3. a kind of preparation method of the nanocomposite of cerium oxide/mesoporous silicon as claimed in claim 1 or 2, feature exist
In including the following steps:
1) cerous acetate hydrate and oleyl amine are added in dimethylbenzene, 3~6h are reacted at 85 DEG C~95 DEG C, aging, precipitating obtain
To cerium oxide nanocrystal；
2) to cerium oxide nanocrystal obtained in step 1), ligand conversion is carried out using 2- bromo acid, obtains ligand conversion
Cerium oxide nanocrystal；
3) hexadecyltrimethylammonium chloride and triethanolamine are then dissolved in water, 0.5~5h are reacted at 90 DEG C~100 DEG C,
It continuously adds ethyl orthosilicate and 3- aminopropyl triethoxysilane reacts 0.5~5h, be centrifuged, washing obtains amido modified
Mesoporous silicon dioxide nano particle；
4) by ligand conversion cerium oxide nanocrystal and amido modified nanometer particle be added in ethyl alcohol, 45 DEG C~
8~15h is reacted at 55 DEG C, obtains cerium oxide/mesoporous silicon nanocomposite.
4. the preparation method of the nanocomposite of cerium oxide/mesoporous silicon according to claim 3, which is characterized in that institute
The mass ratio of cerous acetate hydrate and oleyl amine is 1:7~9 in the step 1) stated.
5. the preparation method of the nanocomposite of cerium oxide/mesoporous silicon according to claim 3, which is characterized in that institute
Hexadecyltrimethylammonium chloride in the step 3) stated, triethanolamine, ethyl orthosilicate and 3- aminopropyl triethoxysilane
Feed ratio are as follows: 1.5~2.5g:0.03~0.05g:1.4~1.6ml:0.14~0.16ml.
6. the preparation method of the nanocomposite of cerium oxide/mesoporous silicon according to claim 3, which is characterized in that institute
The mass ratio of ligand is converted in the step 4) stated cerium oxide nanocrystal and amido modified nanometer particle is 1~20.
7. the preparation method of the nanocomposite of cerium oxide/mesoporous silicon according to claim 3, which is characterized in that institute
In the step 2) stated ligand conversion refer to, by cerium oxide nanocrystal obtained in step 1), 2- bromo acid and citric acid according to
Secondary 20~the 30h of in the mixed solvent stirring for being added to chloroform and N-N dimethylformamide.
8. a kind of nanocomposite of cerium oxide/mesoporous silicon as claimed in claim 1 or 2 treats wound healing medicine in preparation
Application in object.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610027779.5A CN106975100B (en) | 2016-01-15 | 2016-01-15 | A kind of nanocomposite and its preparation method and application of cerium oxide/mesoporous silicon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610027779.5A CN106975100B (en) | 2016-01-15 | 2016-01-15 | A kind of nanocomposite and its preparation method and application of cerium oxide/mesoporous silicon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106975100A CN106975100A (en) | 2017-07-25 |
| CN106975100B true CN106975100B (en) | 2019-06-11 |
Family
ID=59341342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610027779.5A Active CN106975100B (en) | 2016-01-15 | 2016-01-15 | A kind of nanocomposite and its preparation method and application of cerium oxide/mesoporous silicon |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106975100B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2699362C2 (en) * | 2018-01-16 | 2019-09-05 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НОВАСКИН" (ООО "Новаскин") | Composition based on cerium dioxide nanoparticles and brown algae polysaccharides for treating wounds |
| CN117860776A (en) * | 2018-06-07 | 2024-04-12 | 国立大学法人大阪大学 | Preventive or therapeutic agent for oxidative stress-induced diseases |
| CN108969757B (en) * | 2018-07-11 | 2021-07-27 | 浙江大学 | MicroRNA-loaded cerium oxide nano composite hydrogel and preparation method and application thereof |
| CN109771644B (en) * | 2019-03-04 | 2020-12-15 | 浙江大学 | Nano composite material, preparation method and application |
| CN110960552B (en) * | 2019-12-28 | 2022-04-05 | 天津大学 | Monoatomic nano enzyme patch for skin wounds and preparation method thereof |
| CN113134109A (en) * | 2021-04-15 | 2021-07-20 | 南开大学 | Cerium dioxide-based nano composite material, preparation method and application |
| CN114949205B (en) * | 2021-11-18 | 2023-12-19 | 昆明理工大学 | Preparation method and application of mesoporous nano material |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102051702A (en) * | 2010-12-03 | 2011-05-11 | 华东理工大学 | Mesoporous silicon oxide particle/degradable polymer nano composite fiber, preparation method and application thereof |
| CN103536625A (en) * | 2013-09-27 | 2014-01-29 | 安徽师范大学 | Nanometer cerium oxide composite and preparation method thereof as well as antioxidant |
| CN104258456A (en) * | 2014-08-29 | 2015-01-07 | 华南理工大学 | Wound repair gel containing hexagonal mesoporous silicon and preparation method thereof |
| CN104491886A (en) * | 2014-12-30 | 2015-04-08 | 东华大学 | Preparation method of meso-porous silicon nanoparticle with reducing/enzyme dual response and targeting property |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9271936B2 (en) * | 2008-03-06 | 2016-03-01 | University Of Maryland | Method for forming mesoporous silica nanoparticles, mesoporous silica nanoparticles, and applications thereof |
-
2016
- 2016-01-15 CN CN201610027779.5A patent/CN106975100B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102051702A (en) * | 2010-12-03 | 2011-05-11 | 华东理工大学 | Mesoporous silicon oxide particle/degradable polymer nano composite fiber, preparation method and application thereof |
| CN103536625A (en) * | 2013-09-27 | 2014-01-29 | 安徽师范大学 | Nanometer cerium oxide composite and preparation method thereof as well as antioxidant |
| CN104258456A (en) * | 2014-08-29 | 2015-01-07 | 华南理工大学 | Wound repair gel containing hexagonal mesoporous silicon and preparation method thereof |
| CN104491886A (en) * | 2014-12-30 | 2015-04-08 | 东华大学 | Preparation method of meso-porous silicon nanoparticle with reducing/enzyme dual response and targeting property |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106975100A (en) | 2017-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106975100B (en) | A kind of nanocomposite and its preparation method and application of cerium oxide/mesoporous silicon | |
| Li et al. | A degradable hydrogel formed by dendrimer-encapsulated platinum nanoparticles and oxidized dextran for repeated photothermal cancer therapy | |
| Wang et al. | Eggshell derived Se-doped HA nanorods for enhanced antitumor effect and curcumin delivery | |
| CN108187046A (en) | A kind of metal organic frame of modified hyaluronic acid masking, nano-particle, nano-particle preparation method and applications | |
| Chockalingam et al. | Gum arabic modified Fe 3 O 4 nanoparticles cross linked with collagen for isolation of bacteria | |
| CN111438368B (en) | Gold-platinum bimetallic nanoenzyme prepared from silk fibroin solution and application thereof | |
| CN110501208B (en) | Folic acid functionalized streptavidin modified magnetic nanoparticle, preparation method and application thereof | |
| CN104491886A (en) | Preparation method of meso-porous silicon nanoparticle with reducing/enzyme dual response and targeting property | |
| US20130095164A1 (en) | Sol-gel nanostructured titania reservoirs for use in the controlled release of drugs in the central nervous system and method of synthesis | |
| CN111228484B (en) | Application of xonotlite and composite biological material containing xonotlite | |
| CN108949151B (en) | Up-conversion luminescence nano composite material with transition metal disulfide growing on surface, preparation method and application | |
| Peng et al. | Second near-infrared photoactivatable hydrogen selenide nanogenerators for metastasis-inhibited cancer therapy | |
| CN106860427B (en) | Cerium oxide/iron oxide/mesoporous silicon nano composite material and preparation method and application thereof | |
| CN106334190B (en) | A kind of multiple response mechanism compound pharmaceutical carrier and preparation method thereof | |
| CN111388747B (en) | Multifunctional inorganic nano glue and preparation method thereof | |
| CN108653805B (en) | Calcium-silicon-based composite bone cement with photothermal effect and preparation method and application thereof | |
| CN110496232B (en) | Magnetic-gold dimer multifunctional nano probe and preparation method and application thereof | |
| JP5439650B2 (en) | Preparation of nanogel-apatite composite | |
| CN113663088A (en) | Preparation method of double-film-coated bionic nano diagnosis and treatment probe | |
| CN113181213A (en) | NP @ Ne compound and preparation method and application thereof | |
| CN108864712B (en) | Anionic amphiphilic short peptide composite hydrogel, and preparation method and application thereof | |
| CN112494515B (en) | Silver nano hydrogel for regulating flora-activated immune response and preparation method and application thereof | |
| CN115212319B (en) | Preparation and application of small-size iron-doped zinc oxide nano composite particles | |
| CN112870375B (en) | Multi-channel bionic nano carrier for cutting off tumor energy supply and preparation method and application thereof | |
| CN112891532B (en) | Nano photo-thermal conversion material and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Ling Daishun Inventor after: Wu Haibin Inventor after: Gao Jianqing Inventor after: Li Fangyuan Inventor before: Ling Daishun Inventor before: Wu Haibin Inventor before: Gao Jianqing Inventor before: Li Fangyuan |
|
| CB03 | Change of inventor or designer information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |