CN106974977A - A kind of green coffee bean extract solution mouthspray preparation and preparation method thereof - Google Patents
A kind of green coffee bean extract solution mouthspray preparation and preparation method thereof Download PDFInfo
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- CN106974977A CN106974977A CN201611024436.XA CN201611024436A CN106974977A CN 106974977 A CN106974977 A CN 106974977A CN 201611024436 A CN201611024436 A CN 201611024436A CN 106974977 A CN106974977 A CN 106974977A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention relates to a kind of mouthspray preparation for health care and preparation method thereof, the preparation includes green coffee bean extract solution.Chlorogenic acid in green coffee bean extract solution plays the role of anti-oxidant, antibacterial, antiviral, oral inflammation can effectively be alleviated, halitosis is removed, it may also be used for refreshed oneself and relieving fatigue, while green coffee bean is without baking, without melanin, the pigment for bakeing coffee can be avoided in tooth staining.
Description
Technical field
The present invention relates to a kind of galenical and preparation method thereof, especially a kind of mouthspray preparation and its preparation side
Method.
Background technology
Green coffee bean extract solution contains caffeine, chlorogenic acid, free fatty, protein, mineral matter isoreactivity composition.
Chlorogenic acid in green coffee bean extract solution have anti-oxidant, anti-aging, antibacterial, it is antiviral, antitumor, reduce blood pressure
Effect, research shows that the green coffee bean extract solution of oral administration makes the chlorogenic acid in green coffee bean extract solution directly act on oral cavity
Inflammation part, can play alleviation oral inflammation, remove the effect such as halitosis；Chlorogenic acid passes through sublingual and oral mucosal absorption, then
Anti-oxidant, anti-aging, antibacterial can be played, antiviral, antitumor, the health-care effect such as reduce blood pressure.
Caffeine in green coffee bean extract solution belongs to central stimulant, can improve the content of intracellular adenosine cyclophosphate.Experiment
Show, the caffeine that common people absorb no more than 300 milligrams for one day that the excited cerebral cortex of energy is inspired enthusiasm, improves and note
Power, self-confidence and operating efficiency and enthusiasm；Strengthen alertness and reduce tired sense, enhancing your vigilance property and the lasting work of maintenance
Make ability；Strengthen recognition capability, shorten the selection reaction time, improve the positive roles such as instantaneous oral memory.And it is green to apply this
Coffee bean extract solution mouthspray preparation, makes caffeine by sublingual and oral mucosal absorption, absorbs more rapid, excitation
Onset time about only needs to 3 ~ 5 minutes；Green coffee bean is without baking used in this green coffee bean extract solution simultaneously, without black
Element, can avoid the pigment for bakeing coffee in tooth staining.
The content of the invention
The present invention provides a kind of for alleviating oral inflammation to receptor, removing halitosis, while refreshing oneself and relieving fatigue rapidly
Mouthspray preparation, the spray agent makes green by being sprayed to the oral cavity of receptor and sublingual using green coffee bean extract solution
Chlorogenic acid in coffee bean extract solution directly acts on oral inflammation position, reaches the effect alleviated oral inflammation, remove halitosis,
Caffeine appropriate in green coffee bean extract solution is circulated by oral cavity and sublingual absorption to the system of receptor simultaneously, with it is rapid allow by
Person reach refresh oneself and relieving fatigue effect.
The technical scheme is that.
A kind of mouthspray preparation, includes following components：Green coffee bean extract solution, sorbierite, sterile deionized water, sorb
Sour potassium, Tween 80, stevioside.
Preferably, a kind of mass fraction of each component of mouthspray preparation is as follows：
The green mass parts of coffee bean extract solution 1000
The mass parts of sorbierite 400 ~ 500；
The mass parts of sterile deionized water 900 ~ 1100；
The mass parts of potassium sorbate 5 ~ 10；
The mass parts of Tween 80 15 ~ 25；
The mass parts of stevioside 0.8 ~ 1.2.
The green coffee bean extract solution is prepared as steps described below：Green coffee bean powder is broken into coarse powder and puts into high pressure
In pot, the water of green 5 times of amounts of coffee bean gross mass is added, after soaking 180 ~ 240 minutes, temperature-pressure was boiled after 15 ~ 30 minutes, was gone out
Material, obtains green coffee bean extract solution after filtering.
The green coffee bean is madder wort Coffea arabica（CoffeaarabicaL.）, middle fruit coffee
（CoffeacanephoraPierreexFroehn.）And big fruit coffee（CoffealibericaBul1.exH1en.）Seed
In at least but be not limited to one kind.
The green coffee bean water content is 7% ~ 13%.
A kind of method for preparing oral spray of the present invention, is carried out as steps described below：
(1) green coffee bean powder is broken into coarse powder to put into pressure cooker, adds the water of green 5 times of amounts of coffee bean gross mass, immersion 180
After ~ 240 minutes, temperature-pressure was boiled after 15 ~ 30 minutes, discharging, and green coffee bean extract solution is obtained after filtering；
(2) weigh standby after sorbierite, potassium sorbate, Tween 80, stevioside plus aseptic deionized water to all dissolvings；
(3) the plant mixed extract of step (1) preparation is weighed, is heated to after boil condition and stops heating, treat the solution
When being naturally cooling to 30-35 DEG C, the material of step (2) preparation is added it to, is well mixed；
(4) by the solution obtained by step (3), take out and filter, oral spray of the present invention is made.
In the preparation process in accordance with the present invention, in the step (3), it is preferable that the plant mixing for weighing step (1) preparation is carried
Thing is taken, is heated to after boil condition and stops heating, when the solution is naturally cooling to 30 DEG C, add it to step (2)
The material of preparation, is well mixed.
The green coffee bean extract solution mouthspray preparation, by sublingual spraying to oral administration, can effectively alleviate mouth
Chamber inflammation, removal halitosis.
The green coffee bean extract solution mouthspray preparation, by sublingual spraying to oral administration, can effectively alleviate mouth
Chamber inflammation, removal halitosis, and can refresh oneself rapidly and relieving fatigue.
The green coffee bean extract solution mouthspray preparation, green coffee bean used is without baking, without melanin, can keep away
The pigment of baking coffee is exempted from tooth staining.
Embodiment
The present invention is further described by the following examples.
Embodiment 1.
(1) green coffee bean 1000g is ground into coarse powder to put into pressure cooker, adds 5kg water, soaked 210 minutes
Afterwards, temperature-pressure was boiled after 20 minutes, discharging, and green coffee bean extract solution is obtained after filtering；
(2) 400g sorbierites, 5g potassium sorbates, 16g Tween 80s, 1g steviosides, plus aseptic deionized water 1100g are weighed to complete
It is standby after portion's dissolving；
(3) the green coffee bean extract solution 1000g of step (1) preparation is weighed, is heated to after boil condition and stops heating, treat this
When solution is naturally cooling to 30 DEG C, the material of step (2) preparation is added it to, is well mixed；
(4) by the solution obtained by step (3), take out and filter, oral spray sample 3 of the present invention is made.
Embodiment 2.
(1) green coffee bean 1000g is ground into coarse powder to put into pressure cooker, adds 5kg water, soaked 220 minutes
Afterwards, temperature-pressure was boiled after 30 minutes, discharging, and green coffee bean extract solution is obtained after filtering；
(2) 500g sorbierites, 6g potassium sorbates, 20g Tween 80s, 1.2g steviosides are weighed, plus aseptic deionized water 1000g is extremely
It is all standby after dissolving；
(3) the green coffee bean extract solution 1000g of step (1) preparation is weighed, is heated to after boil condition and stops heating, treat this
When solution is naturally cooling to 35 DEG C, the material of step (2) preparation is added it to, is well mixed；
(4) by the solution obtained by step (3), take out and filter, oral spray sample 4 of the present invention is made.
Embodiment 3.
(1) green coffee bean 1000g is ground into coarse powder to put into pressure cooker, adds 5kg water, soaked 240 minutes
Afterwards, temperature-pressure was boiled after 20 minutes, discharging, and green coffee bean extract solution is obtained after filtering；
(2) 480g sorbierites, 9g potassium sorbates, 25g Tween 80s, 0.8g steviosides are weighed, plus aseptic deionized water 1000g is extremely
It is all standby after dissolving；
(3) the green coffee bean extract solution 1000g of step (1) preparation is weighed, is heated to after boil condition and stops heating, treat this
When solution is naturally cooling to 30 DEG C, the material of step (2) preparation is added it to, is well mixed；
(4) by the solution obtained by step (3), take out and filter, oral spray sample 5 of the present invention is made.
Embodiment 4.
(1) green coffee bean 1000g is ground into coarse powder to put into pressure cooker, adds 5kg water, soaked 240 minutes
Afterwards, temperature-pressure was boiled after 25 minutes, discharging, and green coffee bean extract solution is obtained after filtering；
(2) 500g sorbierites, 5g potassium sorbates, 20g Tween 80s, 1g steviosides, plus aseptic deionized water 900g are weighed to complete
It is standby after portion's dissolving；
(3) the green coffee bean extract solution 1000g of step (1) preparation is weighed, is heated to after boil condition and stops heating, treat this
When solution is naturally cooling to 30 DEG C, the material of step (2) preparation is added it to, is well mixed；
(4) by the solution obtained by step (3), take out and filter, oral spray sample 6 of the present invention is made.
Testing example 1.
The oral spray that this testing example investigates the present invention alleviates oral inflammation, removes the effect of halitosis.
The subject that choosing 50 oral cavities has different degrees of inflammation or have halitosis situation uses this sample 1-6 daily 3 ~ 5 times,
Continue 7 days, 90% subject's halitosis situation disappears or oral inflammation situation is improved, and without discovery adverse reaction.
The preferred embodiment of the present invention is the foregoing described, still, the present invention is not limited to the tool in above-mentioned embodiment
Body details, in the technical scope of the present invention, can carry out a variety of simple variants to technical scheme, these simple changes
Type belongs to protection scope of the present invention.
Testing example 2.
This testing example investigates the rapid of the oral spray of the present invention and refreshes oneself and release tired action effect and to stomach and intestine
The excitant in road.
50 subjects for there are coffee consumption habits of 16 ~ 50 years old are chosen, 50 subjects are when sleepy or tired
Carry out use this sample 1-6,94% subject played in 3 ~ 5 minutes inspire enthusiasm, improves notice, reduce it is tired feel,
Strengthen recognition capability, shorten the selection reaction time, improve the positive roles such as instantaneous oral memory, and without not feeling well.
Testing example 3.
This testing example investigates the security of the oral spray of the present invention.
50 subjects in testing example 2 use this sample 1-6 daily 3 ~ 5 times, continue 1 month, 96% subject
Without discovery adverse reaction, and represent that tested period improves notice, self-confidence and operating efficiency and enthusiasm.
Claims (8)
1. a kind of green coffee bean extract solution mouthspray preparation, it is characterised in that it contains green coffee bean extract solution, sorbierite
, sterile deionized water, potassium sorbate, Tween 80, stevioside.
2. a kind of green coffee bean extract solution mouthspray preparation according to claim 1, it is characterised in that it is respectively constituted into
Part mass fraction be：
The green mass parts of coffee bean extract solution 1000；
The mass parts of sorbierite 400 ~ 500；
The mass parts of sterile deionized water 900 ~ 1100；
The mass parts of potassium sorbate 5 ~ 10；
The mass parts of Tween 80 15 ~ 25；
The mass parts of stevioside 0.8 ~ 1.2.
3. a kind of green coffee bean extract solution mouthspray preparation according to claim 1 or 2, it is characterised in that described green
Coffee bean extract solution is prepared as steps described below：Green coffee bean powder is broken into coarse powder to put into pressure cooker, green coffee is added
The water of 5 times of amounts of coffee beans gross mass, after soaking 180 ~ 240 minutes, temperature-pressure was boiled after 15 ~ 30 minutes, discharging, was obtained after filtering
Green coffee bean extract solution.
4. a kind of green coffee bean extract solution mouthspray preparation according to claim 3, it is characterised in that the green coffee
Beans are madder wort Coffea arabica（CoffeaarabicaL.）, middle fruit coffee（Coffeacanephora Pierreex
Froehn.）And big fruit coffee（CoffealibericaBul1.exH1en.）Seed in one or more kinds of mixing.
5. a kind of green coffee bean extract solution mouthspray preparation according to claim 4, it is characterised in that the green coffee
Beans water content is 7% ~ 13%.
6. a kind of method for preparing oral spray, it is characterised in that carry out as steps described below：
(1) green coffee bean powder is broken into coarse powder to put into pressure cooker, adds the water of green 5 times of amounts of coffee bean gross mass, immersion 180
After ~ 240 minutes, temperature-pressure was boiled after 15 ~ 30 minutes, discharging, and green coffee bean extract solution is obtained after filtering；
(2) weigh standby after sorbierite, potassium sorbate, Tween 80, stevioside, plus aseptic deionized water to all dissolvings；
(3) the plant mixed extract of step (1) preparation is weighed, is heated to after boil condition and stops heating, treat the solution
When being naturally cooling to 30-35 DEG C, the material of step (2) preparation is added it to, is well mixed；
(4) by the solution obtained by step (3), take out and filter, oral spray of the present invention is made.
7. a kind of method for preparing oral spray according to claim 6, it is characterised in that excellent in the step (3)
Selection of land, weighs the plant mixed extract of step (1) preparation, is heated to after boil condition and stops heating, treats the solution certainly
When being so cooled to 30 DEG C, the material of step (2) preparation is added it to, is well mixed.
8. a kind of mouthspray preparation according to any one of claim 1-5, it is characterised in that it passes through sublingual spraying
To oral administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611024436.XA CN106974977A (en) | 2016-11-22 | 2016-11-22 | A kind of green coffee bean extract solution mouthspray preparation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611024436.XA CN106974977A (en) | 2016-11-22 | 2016-11-22 | A kind of green coffee bean extract solution mouthspray preparation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106974977A true CN106974977A (en) | 2017-07-25 |
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ID=59340835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611024436.XA Pending CN106974977A (en) | 2016-11-22 | 2016-11-22 | A kind of green coffee bean extract solution mouthspray preparation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653087A (en) * | 2018-06-27 | 2018-10-16 | 浙江汉洁雅科技有限公司 | A kind of mouthwash with anti-inflammatory and bacteriostasis |
| CN116391858A (en) * | 2023-04-07 | 2023-07-07 | 仙乐健康科技股份有限公司 | Composition capable of reducing oral sulfide |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101808653A (en) * | 2007-09-26 | 2010-08-18 | 高砂香料工业株式会社 | Plant extract and use thereof |
| CN102198065A (en) * | 2011-05-30 | 2011-09-28 | 天津天狮生物发展有限公司 | Oral spray and preparation method thereof |
| CN103360258A (en) * | 2013-08-08 | 2013-10-23 | 内蒙古鑫吉利生物科技有限公司 | Method for extracting chlorogenic acid from coffee beans |
| CN103705600A (en) * | 2013-12-26 | 2014-04-09 | 晨光生物科技集团股份有限公司 | Method for producing green coffee bean extract |
-
2016
- 2016-11-22 CN CN201611024436.XA patent/CN106974977A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101808653A (en) * | 2007-09-26 | 2010-08-18 | 高砂香料工业株式会社 | Plant extract and use thereof |
| CN102198065A (en) * | 2011-05-30 | 2011-09-28 | 天津天狮生物发展有限公司 | Oral spray and preparation method thereof |
| CN103360258A (en) * | 2013-08-08 | 2013-10-23 | 内蒙古鑫吉利生物科技有限公司 | Method for extracting chlorogenic acid from coffee beans |
| CN103705600A (en) * | 2013-12-26 | 2014-04-09 | 晨光生物科技集团股份有限公司 | Method for producing green coffee bean extract |
Non-Patent Citations (2)
| Title |
|---|
| 王丽萍；等: "中药绿原酸的研究进展", 《时珍国医国药》 * |
| 王立志；等: "绿咖啡豆中总绿原酸的纯化工艺研究", 《中国食品添加剂》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653087A (en) * | 2018-06-27 | 2018-10-16 | 浙江汉洁雅科技有限公司 | A kind of mouthwash with anti-inflammatory and bacteriostasis |
| CN116391858A (en) * | 2023-04-07 | 2023-07-07 | 仙乐健康科技股份有限公司 | Composition capable of reducing oral sulfide |
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Application publication date: 20170725 |