CN106970043A - Urea nitrogen content on-line monitoring method and system in a kind of hemodialysis dialyzate - Google Patents
Urea nitrogen content on-line monitoring method and system in a kind of hemodialysis dialyzate Download PDFInfo
- Publication number
- CN106970043A CN106970043A CN201710284675.7A CN201710284675A CN106970043A CN 106970043 A CN106970043 A CN 106970043A CN 201710284675 A CN201710284675 A CN 201710284675A CN 106970043 A CN106970043 A CN 106970043A
- Authority
- CN
- China
- Prior art keywords
- dialyzate
- hemodialysis
- urea nitrogen
- near infrared
- nitrogen content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 title claims abstract description 88
- 238000012544 monitoring process Methods 0.000 title claims abstract description 85
- 238000001631 haemodialysis Methods 0.000 title claims abstract description 77
- 230000000322 hemodialysis Effects 0.000 title claims abstract description 77
- 238000000034 method Methods 0.000 title claims abstract description 17
- 239000008280 blood Substances 0.000 claims description 60
- 210000004369 blood Anatomy 0.000 claims description 60
- 238000002329 infrared spectrum Methods 0.000 claims description 37
- 239000000523 sample Substances 0.000 claims description 34
- 230000004087 circulation Effects 0.000 claims description 26
- 238000000502 dialysis Methods 0.000 claims description 22
- 238000001228 spectrum Methods 0.000 claims description 21
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 230000017531 blood circulation Effects 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 13
- 210000003462 vein Anatomy 0.000 claims description 12
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 11
- 239000004202 carbamide Substances 0.000 claims description 11
- 229960002897 heparin Drugs 0.000 claims description 11
- 229920000669 heparin Polymers 0.000 claims description 11
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 10
- 239000000385 dialysis solution Substances 0.000 claims description 10
- 238000004064 recycling Methods 0.000 claims description 10
- 210000001367 artery Anatomy 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 230000003595 spectral effect Effects 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 3
- 239000003182 parenteral nutrition solution Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000004497 NIR spectroscopy Methods 0.000 claims description 2
- 238000012360 testing method Methods 0.000 abstract description 3
- 208000017169 kidney disease Diseases 0.000 abstract description 2
- 239000012528 membrane Substances 0.000 description 5
- 238000009738 saturating Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 206010029164 Nephrotic syndrome Diseases 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 208000020832 chronic kidney disease Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 208000009928 nephrosis Diseases 0.000 description 2
- 231100001027 nephrosis Toxicity 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000022558 protein metabolic process Effects 0.000 description 2
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000009615 deamination Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 208000028208 end stage renal disease Diseases 0.000 description 1
- 201000000523 end stage renal failure Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 201000006334 interstitial nephritis Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000009659 non-destructive testing Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000192 social effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
Abstract
The present invention relates to urea nitrogen content on-line monitoring method and system in a kind of hemodialysis dialyzate, dialysate samples testing model is set up using near infrared spectrometer and the changes of contents of urea nitrogen in hemodialysis dialyzate is monitored on-line, monitored, prevented according to the changes of contents rule of urea nitrogen in hemodialysis dialyzate, avoiding hemodialysis accident from occurring, so as to provide scientific basis for the treatment of uremic patient, the purpose for improving patient's treatment of kidney disease level is reached.
Description
Technical field
It is more particularly to a kind of the present invention relates to urea nitrogen content on-line monitoring method and system in a kind of hemodialysis dialyzate
Urea nitrogen content on-line monitoring method and system in the hemodialysis dialyzate detected using near infrared spectrum.
Background technology
At present, blood purification in clinical treatment by widespread need.By taking kidney trouble dialysis treatment as an example, China there are about 200
Ten thousand End-stage Renal Disease Patients, 400,000 are receiving hemodialysis, every year with the speed increase more than 10%, and patient is controlled dialysis
The demand for the treatment of is very big.
Blood dialysis therapy is the principle using pellicle, and the blood of patient and dialyzate are introduced inside and outside dialyzer simultaneously
Side, by means of solute gradient, osmotic gradient and the spread of film both sides, by diffusion, convection current, removes toxin etc., by this
Method removes the excessive moisture and metabolic waste of internal retention, while leaving required material, corrects electrolyte and soda acid is flat
Weighing apparatus is disorderly.
Urea is the main dead end product of human body protein metabolism, and amino acid deamination produces NH3And C02, both are in liver
Middle urea synthesis, every gram of protein metabolism produces about 0.3 gram of urea nitrogen.Usual kidney is the major organs of excretion urea, urea
Can reabsorption in each section of tubule after glomerular filtration.Normal adult's empty stomach urea nitrogen be 3.2~7.1mmol/L (9~
20mg/d1).Various parenchymal lesion of the kidney, such as glomerulonephritis, interstitial nephritis, acute or chronic renal failure can make blood
Urea nitrogen increases.If excluding kidney other factor, urea nitrogen 21.4mmol/L (60mg/d1) is one of uremia diagnosis index.
When carrying out hemodialysis to uremic patient, dialyzer need to be used.Dialyzer is likely to occur blocking or damaged
Phenomenon.The reason for dialyzer is blocked mainly has：A, blood are oversize from the pump time in vitro, and this is the main cause that dialyzer is blocked；
B, heparin consumption are not enough, patient dialyse first heparin injection rate it is particularly significant, usually 0.2~0.5mg/kg, if first
Test tube of hepari is insufficient, and additional heparin amount is big also without positive effect again in dialysis；C, dialysis person itself because of disease, nephrosis whole latter stage,
Blood viscosity increases.
Dialyzer be blocked after should change in time, otherwise extracorporal circulatory system stop, arterial blood line, vein bloody path also can therewith by
It is stifled, cause dialysis person's blood largely to lose, it is very harmful.And observe general 5~10 minutes of the process that dialyzer is blocked, in order to and
Shi Faxian dialyzer cloggings, it is necessary to monitored on-line to dialysis procedure, search out the changing rule of dialysate concentration.
Such as when dialysis membrane is progressively blocked, urea nitrogen content in dialyzate can gradually step-down, when with normal urea nitrogen content more than one
When fixed limit is spent, it can in time be reminded by warning device, be prevented effectively from the generation of harm.
Furthermore, by monitoring the change of urea nitrogen content in hemodialysis dialyzate on-line, the damaged feelings of dialyzer can be found in time
Condition.When hollow-fibre membrane such as dialyzer occurs damaged, the urea nitrogen content in dialyzate can be significantly improved, can be with by monitoring
Find that dialyzer is damaged, handles and avoid the generation of accident in time in time.
Prior art is prevented using electrical conductivity detection, dialysate concentration monitoring etc., but there is also certain shortcoming, such as
Sample the promptness of detection not enough and producing pollution, concentration monitor needs high-precision sensor, sensor probe to occur
Corrosion phenomenon and the generation for causing situations such as measured value is inaccurate.
Near-infrared spectrum technique is the new technique just grown up in recent years, is quickly to scan thing near infrared spectrometer
A kind of Instrumental Analysis means of the matter in the reflection, diffusing reflection or transmitted spectrum of 670~2526nm SPECTRAL REGIONs.Due near infrared light
Spectral analysis technology has that analyze speed is fast, efficiency high, sample are without chemical contamination, without sample pretreatment, online Non-Destructive Testing etc.
Advantage, is widely applied in fields such as food and agricultural products detections at present.But literature search does not find that it is applied to blood
Dialysis on-line monitoring field.
Therefore urea nitrogen content in the advantage of Near Infrared Spectroscopy Detection Technology, on-line monitoring hemodialysis dialyzate how is combined
Change, find hemodialysis when dialyzate in urea nitrogen content changing rule, find hemodialysis when dialyzate in urea nitrogen content change
With the correlation between Heart Rate, blood pressure, dialysis blood flow, urea nitrogen content in dialyzate is found such as stifled in special circumstances
One of changing rule under plug or breakage, problem as the area research.
The content of the invention
The present invention is supervised online there is provided urea nitrogen content in a kind of hemodialysis dialyzate to solve the problem of prior art is present
Method and system are surveyed, dialysate samples testing model is set up using near infrared spectrometer and urea in hemodialysis dialyzate is monitored on-line
The changes of contents of nitrogen, reaches that the purpose for the treatment of of kidney disease level occurs, improved for prevention hemodialysis accident.
The present invention provides urea nitrogen content on-line monitoring method in a kind of hemodialysis dialyzate, comprises the following steps：
1) the hemodialysis dialysate samples of different urea nitrogen contents are prepared；
2) spectra collection is carried out to above-mentioned dialysate samples using near infrared spectrometer；
3) set up urea nitrogen content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, by the saturating of collection
Near infrared spectrum and the step 3 of urea nitrogen content in parser outlet dialyzate) foundation dialyzate in urea nitrogen content quantitatively reflect
Other model is compared, and quickly determines the urea nitrogen content in dialyzer outlet to be checked dialyzate.
In addition, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, including：Blood side is followed
Ring, dialysis fluid side circulation and dialyzer 4；The circulation of blood side includes, and human body artery blood outlet side 1, blood pump 2, arterial blood are followed
Ring conduit 3, venous blood circulation conduit 6 and human vein blood input side 8；Arterial circulation conduit 3 connects human body artery
The blood entry port of blood outlet side 1 and dialyzer 4, blood pump 2 is arranged on arterial circulation conduit 3；Venous blood circulation is led
The blood outlet of the connection dialyzer 4 of pipe 6 and human vein blood input side 8；Dialysis fluid side circulation includes, dialyzate bucket 9, dialysis
It is liquid pump 10, dialyzate inlet line 11, dialyzate monitoring probe 14, dialyzate outlet line 13, dialyzate recycling bin 15, near red
External spectrum detects data circuit 16 and near infrared light spectrum monitoring instrument 17；The connection dialyzate of dialyzate inlet line 11 bucket 9 and dialysis
The dialyzate entrance of device 4, dialysis liquid pump 10 is arranged in dialyzate inlet line 11；Dialyzate outlet line 13 connects dialyzer
4 dialyzate outlet and dialyzate recycling bin 15；Dialyzate monitoring probe 14 is arranged on dialyzate outlet line 13, near-infrared
The connection dialyzate monitoring of spectral detection data circuit 16 probe 14 and near infrared light spectrum monitoring instrument 17；Dialyzate monitoring probe 14 is adopted
The near infrared spectrum of urea nitrogen content in collecting the dialyzate come out from dialyzer 4.
Further, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, also with following
Feature：Near infrared light spectrum monitoring instrument 17 monitors the near infrared spectrum of urea nitrogen content during probe 14 obtains dialyzate from dialyzate,
Urea nitrogen content quantitatively differentiates that model comparison obtains urea nitrogen in hemodialysis dialyzate in hemodialysis dialyzate based near infrared spectrum
Content is simultaneously recorded in real time.
Further, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, also with following
Feature：Urea nitrogen content quantitatively differentiates that model refers to prepare different urea nitrogen contents in hemodialysis dialyzate based near infrared spectrum
Hemodialysis dialysate samples, spectra collection is carried out to the dialysate samples using near infrared spectrometer, so as to set up based near
Urea nitrogen content quantitatively differentiates model in the hemodialysis dialyzate of infrared spectrum.
Further, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, also with following
Feature：Urea nitrogen content on-line monitoring system is provided with bubble capture monitor 7 in hemodialysis dialyzate, is arranged on venous blood circulation
On conduit 6.
Further, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, also with following
Feature：Dialyzate monitoring probe 14 includes probing shell 21, dialyzate passage 24, near-infrared receiving chamber 29 and near infrared emission room
32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at the both sides of probing shell 21, and centre is passed through by dialyzate passage 24
Probing shell 21 is worn, near-infrared receiving chamber 29 and near infrared emission room 32 pass through near-infrared receiving batter 25 and near infrared emission respectively
The connection dialyzate passage of hole 30 24, near-infrared receiving batter 25 and near infrared emission hole 30 are coaxial；Near infrared emission room 32 is near red
The position of outer launch hole 30 is provided near infrared emission pipe 31；Near-infrared receiving chamber 29 is in the position of near-infrared receiving batter 25 provided near
Infrared receiving tube 27；Near-infrared receiving chamber 29 is connected provided with circuit board 28 with near-infrared receiving closed tube 27；Dialyzate passage 24 with thoroughly
The dialyzate of parser 4 is exported or dialyzate outlet line 13 is connected and be transported to used dialyzate recycling bin 15；Probing shell 21
Outside is provided with connector 23, and connector 23 connects near-infrared receiving chamber 29, near infrared emission room 32 and outside by wire guide 22；
Dialyzate passage 24 is provided with the covering near-infrared receiving of quartz glass 33 batter 25 and near infrared emission hole 30；Dialyzate monitoring probe 14
Also include two connection probing shells 21 of closure 26 and form near-infrared receiving chamber 29 and near infrared emission room 32 respectively；Near-infrared
Dialyzate in light monitoring dialyzate passage 24, the spectral signal of collection passes through even through dialyzate monitoring 14 inner leads of probe
Joint 23 is drawn from conduit, detects that data circuit, near infrared light spectrum monitoring instrument are obtained in hemodialysis dialyzate through near infrared spectrum
Urea nitrogen content is simultaneously recorded in real time.
Further, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, also with following
Feature：Closure 26 is threadedly coupled with probing shell 21 by sealing.
Further, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, also with following
Feature：Connector 23, probing shell 21 and closure 26 use stainless steel.
Further, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, also with following
Feature：Dialyzate near infrared light normal transmission dialyzate passage 24.
Further, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, also with following
Feature：Urea nitrogen content on-line monitoring system is arranged on arterial circulation conduit 3 provided with heparin pump 20 in hemodialysis dialyzate；
The parenteral solution of preparation injects blood through heparin pump 20.
Unaccounted technical characteristic and experimental procedure etc. are carried out supporting using ripe prior art in the present invention.
The beneficial effect of invention
1st, by the content of urea nitrogen in on-line real time monitoring dialyzate, it can quickly judge whether dialyzer blocks
Or disrepair phenomenon, so as to handle, prevent the generation of malpractice in time；
2nd, the detection time of on-line monitoring is short, and urea nitrogen content data are more in the dialyzate of acquisition, help to find out hemodialysis
When dialyzate in urea nitrogen content changing rule, when helping to search out hemodialysis in dialyzate urea nitrogen content change and patient
Correlation between heart rate, blood pressure, dialysis blood flow, so as to provide scientific basis for the treatment of uremic patient；
3rd, Fast nondestructive evaluation is really realized, compared with other monitoring methods, human error and systematic error are effectively reduced,
Model accuracy rate is high, improves operating efficiency；
Reliable technology guarantee is provided for the prevention, treatment, first aid of nephrosis, economy, social effect are huge.
Brief description of the drawings
Fig. 1 is urea nitrogen content on-line monitoring system schematic diagram in a kind of hemodialysis dialyzate of the present invention.
The structural representation that Fig. 2 pops one's head in for the dialyzate monitoring in the present invention.
Reference:
1- human body artery blood outlet sides；2- blood pumps；3- arterial circulation conduits；4- dialyzers；5- hollow-fibre membranes；
6- venous blood circulation conduits；7- bubble capture monitors；8- human vein blood input sides；The clean dialyzate buckets of 9-；10- is saturating
Analyse liquid pump；11- dialyzate inlet lines；12- dialyzer dialysis fluid sides；13- dialyzate outlet lines；The monitoring of 14- dialyzates is visited
Head；The used dialyzate recycling bins of 15-；16- near infrared spectrums detect data circuit；17- near infrared light spectrum monitoring instruments；20- livers
Plain pump；21- probing shells；22- wire guides；23- connectors；24- dialyzate passages；25- near-infrared receiving batters；26- closures；
27- near-infrared receiving closed tubes；28- circuit boards；29- near-infrared receiving chambers；30- near infrared emissions hole；31- near infrared emission pipes；32-
Near infrared emission room；33- quartz glass.
Embodiment
The present invention will be further described with specific embodiment below in conjunction with the accompanying drawings.
A kind of urea nitrogen content on-line monitoring method in hemodialysis dialyzate, this method comprises the following steps：
1) the hemodialysis dialysate samples of different urea nitrogen contents are prepared, sample size, which is met, sets up wanting for Sample model
Ask；
2) spectra collection is carried out to above-mentioned dialysate samples using near infrared spectrometer；
3) set up urea nitrogen content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, by the saturating of collection
Near infrared spectrum and the step 3 of urea nitrogen content in parser outlet dialyzate) foundation dialyzate in urea nitrogen content quantitatively reflect
Other model is compared, and quickly determines the urea nitrogen content in dialyzer outlet to be checked dialyzate.Fig. 1 is a kind of blood of the invention
Urea nitrogen content on-line monitoring system schematic diagram in saturating dialyzate.
As shown in figure 1, urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, including：The circulation of blood side, dialysis
Circulate and dialyzer 4 liquid side.Dialyzer 4 has hollow-fibre membrane 5 and dialysis fluid side 12.
The circulation of blood side includes：Human body artery blood outlet side 1, blood pump 2, the venous blood of arterial circulation conduit 3 are followed
Ring conduit 6 and human vein blood input side 8.The connection human body artery blood of arterial circulation conduit 3 outlet side 1 and dialyzer
4 blood entry port, blood pump 2 is arranged on arterial circulation conduit 3；Venous blood circulation conduit 6 connects the blood of dialyzer 4
Outlet and human vein blood input side 8.
Dialysis fluid side circulation includes, dialyzate bucket 9, dialysis liquid pump 10, dialyzate inlet line 11, dialyzate monitoring probe
14th, the dialyzate recycling bin 15 of dialyzate outlet line 13, near infrared spectrum detection data circuit 16 and near infrared light spectrum monitoring instrument
17.The dialyzate entrance of the connection dialyzate of dialyzate inlet line 11 bucket 9 and dialyzer 4, dialysis liquid pump 10 is arranged on dialyzate
In inlet line 11；The dialyzate outlet of the connection dialyzer 4 of dialyzate outlet line 13 and dialyzate recycling bin 15；Dialyzate is supervised
Probing first 14 is arranged on dialyzate outlet line 13, the near infrared spectrum detection connection dialyzate monitoring of data circuit 16 probe 14
With near infrared light spectrum monitoring instrument 17；Urea nitrogen content in the dialyzate that the collection of dialyzate monitoring probe 14 comes out from dialyzer 4
Near infrared spectrum；Near infrared light spectrum monitoring instrument 17 monitors the near-infrared of urea nitrogen content during probe 14 obtains dialyzate from dialyzate
Urea nitrogen content quantitatively differentiates that model is compared and obtains urinating in hemodialysis dialyzate in spectrum, the hemodialysis dialyzate based near infrared spectrum
Plain nitrogen content is simultaneously recorded in real time.
Urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, in addition to bubble capture monitor 7 and heparin pump
20.Bubble capture monitor 7 is arranged on venous blood circulation conduit 6.Heparin pump 20 is arranged on arterial circulation conduit 3
On.
The workflow of urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate：The human body artery of blood side circulation
The blood that blood outlet side 1 is exported enters dialyzer 4 through blood pump 2, arterial circulation conduit 3, and blood is through in dialyzer 4
Hollow fiber film 5 carries out solute with dialyzate and exchanged, then returns to people through venous blood circulation conduit 6, human vein blood input side 8
Body.Dialyzate in the clean dialyzate bucket 9 of dialysis fluid side circulation enters through dialyse liquid pump 10, dialyzate inlet line 11 dialyses
Device dialysis fluid side 12, carries out solute with the blood in hollow-fibre membrane 5 and exchanges, then monitor the dialyzate in probe 14 through dialyzate
Passage, dialyzate outlet line 13 enter used dialyzate recycling bin 15；The collection of dialyzate monitoring probe 14 goes out from dialyzer 4
The near infrared spectrum of the dialyzate come, detects data circuit 16, near infrared light spectrum monitoring instrument 17, with based near through near infrared spectrum
Urea nitrogen content quantitatively differentiates that model is compared and obtains in hemodialysis dialyzate urea nitrogen content simultaneously in the hemodialysis dialyzate of infrared spectrum
Record in real time.
Urea nitrogen content quantitatively differentiates that model refers to prepare different urea nitrogens in hemodialysis dialyzate based near infrared spectrum
The dialysate samples are carried out spectra collection, so as to set up base by the hemodialysis dialysate samples of content using near infrared spectrometer
Urea nitrogen content quantitatively differentiates model in the hemodialysis dialyzate of near infrared spectrum.
The blood come out from dialyzer 4 is defeated through venous blood circulation conduit 6, bubble capture monitor 7, human vein blood
Enter side 8 and return to human body.
The blood that human body artery blood outlet side 1 is exported enters saturating through blood pump 2, heparin pump 20, arterial circulation conduit 3
Parser 4；The parenteral solution of preparation injects blood through heparin pump 20.The structural representation that Fig. 2 pops one's head in for the dialyzate monitoring in the present invention
Figure.
As shown in Fig. 2 dialyzate monitoring probe 14 includes probing shell 21, dialyzate passage 24, near-infrared receiving chamber 29
With near infrared emission room 32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at the both sides of probing shell 21, it is middle by
Dialyzate passage 24 runs through probing shell 21, and near-infrared receiving chamber 29 and near infrared emission room 32 pass through near-infrared receiving batter respectively
25 connect dialyzate passage 24 near infrared emission hole 30, and near-infrared receiving batter 25 and near infrared emission hole 30 are coaxial；Near-infrared
Bay 32 is provided near infrared emission pipe 31 in the position near infrared emission hole 30；Near-infrared receiving chamber 29 is in near-infrared receiving batter
25 position is provided with near-infrared receiving closed tube 27；Near-infrared receiving chamber 29 is connected provided with circuit board 28 with near-infrared receiving closed tube 27；Thoroughly
Analysis liquid passage 24 is exported with the dialyzate of dialyzer 4 or dialyzate outlet line 13 is connected and be transported to used dialyzate recycling bin
15。
The outside of probing shell 21 is provided with connector 23, and connector 23 connects near-infrared receiving chamber 29 by wire guide 22, near
Infrared emission room 32 and outside；Dialyzate passage 24 is provided with the covering near-infrared receiving of quartz glass 33 batter 25 and near infrared emission hole
30；Dialyzate monitoring probe 14 also includes two connection probing shells 21 of closure 26 and forms near-infrared receiving chamber 29 respectively and near
Infrared emission room 32.
Dialyzate near infrared light monitoring dialyzate passage 24, the spectral signal of collection is through dialyzate monitoring probe 14
Inner lead is drawn by connector 23 from conduit, detects that data circuit, near infrared light spectrum monitoring instrument are obtained through near infrared spectrum
Urea nitrogen content and recorded in real time into hemodialysis dialyzate.
Closure 26 is threadedly coupled with probing shell 21 by sealing.
Connector 23, probing shell 21 and closure 26 use stainless steel.
Dialyzate near infrared light normal transmission dialyzate passage 24.
Unaccounted technical characteristic and experimental procedure etc. are carried out supporting using ripe prior art in the present invention.
Although the present invention is disclosed as above with preferred embodiment, they be not for limiting the present invention, it is any to be familiar with
This area technical professional, without departing from the spirit and scope of the invention, the variations, modifications, additions or substitutions made,
Still fall within the protection domain of technical solution of the present invention.
Claims (10)
1. urea nitrogen content on-line monitoring method in a kind of hemodialysis dialyzate, it is characterised in that：
This method comprises the following steps：
1) the hemodialysis dialysate samples of different urea nitrogen contents are prepared；
2) spectra collection is carried out to above-mentioned dialysate samples using near infrared spectrometer；
3) set up urea nitrogen content in the hemodialysis dialyzate based near infrared spectrum and quantitatively differentiate model；
4) near infrared spectra collection is carried out to hemodialysis dialyzer outlet dialyzate using on-line monitoring probe, by the dialyzer of collection
Near infrared spectrum and the step 3 of urea nitrogen content in outlet dialyzate) urea nitrogen content quantitatively differentiates mould in the dialyzate set up
Type is compared, and quickly determines the urea nitrogen content in dialyzer outlet to be checked dialyzate.
2. urea nitrogen content on-line monitoring system in a kind of hemodialysis dialyzate, it is characterised in that：
Including the circulation of blood side, dialysis fluid side circulation and dialyzer (4)；
Described blood side circulation includes, human body artery blood outlet side (1), blood pump (2), arterial circulation conduit (3), quiet
Arteries and veins blood circulation conduit (6) and human vein blood input side (8)；The arterial circulation conduit (3) connects the human body
The blood entry port of arterial blood outlet side (1) and the dialyzer (4), the blood pump (2) is arranged on the arterial circulation
On conduit (3)；The venous blood circulation conduit (6) connects the blood outlet of the dialyzer (4) and the human vein blood
Liquid input side (8)；
Described dialysis fluid side circulation includes, dialyzate bucket (9), dialysis liquid pump (10), dialyzate inlet line (11), dialyzate
Monitoring probe (14), dialyzate outlet line (13), dialyzate recycling bin (15), near infrared spectrum detection data circuit (16) and
Near infrared light spectrum monitoring instrument (17)；The dialyzate inlet line (11) connects the dialyzate bucket (9) and the dialyzer (4)
Dialyzate entrance, the dialysis liquid pump (10) is arranged on the dialyzate inlet line (11)；The dialyzate outlet
Line (13) connects the dialyzate outlet of the dialyzer (4) and the dialyzate recycling bin (15)；The dialyzate monitoring probe
(14) it is arranged on the dialyzate outlet line (13), the near infrared spectrum detection data circuit (16) connects the dialysis
Liquid monitoring probe (14) and the near infrared light spectrum monitoring instrument (17)；The dialyzate monitoring probe (14) is gathered from the dialysis
The near infrared spectrum of urea nitrogen content in the dialyzate that device (4) comes out.
3. urea nitrogen content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：It is described near
Infrared spectroscopy monitor instrument (17) monitors the near infrared spectrum of urea nitrogen content during probe (14) obtains dialyzate from the dialyzate,
Urea nitrogen content quantitatively differentiates that model comparison obtains urea nitrogen in hemodialysis dialyzate in hemodialysis dialyzate based near infrared spectrum
Content is simultaneously recorded in real time.
4. urea nitrogen content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
Urea nitrogen content quantitatively differentiates that model refers to prepare different urea in the described hemodialysis dialyzate based near infrared spectrum
The dialysate samples are carried out spectra collection, so as to set up by the hemodialysis dialysate samples of nitrogen content using near infrared spectrometer
Urea nitrogen content quantitatively differentiates model in hemodialysis dialyzate based near infrared spectrum.
5. urea nitrogen content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
Urea nitrogen content on-line monitoring system is provided with bubble capture monitor (7) in described hemodialysis dialyzate, is arranged on vein
On blood circulation conduit (6).
6. urea nitrogen content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
Described dialyzate monitoring probe (14) includes probing shell (21), dialyzate passage (24), near-infrared receiving chamber (29)
With near infrared emission room (32)；Described near-infrared receiving chamber (29) and near infrared emission room (32) is respectively provided at probing shell
(21) both sides, it is middle that probing shell (21), near-infrared receiving chamber (29) and near infrared emission room are run through by dialyzate passage (24)
(32) dialyzate passage (24), near-infrared receiving batter are connected near infrared emission hole (30) by near-infrared receiving batter (25) respectively
And near infrared emission hole (30) are coaxial (25)；Described near infrared emission room (32) is provided with the position of near infrared emission hole (30)
Near infrared emission pipe (31)；Described near-infrared receiving chamber (29) is received in the position of near-infrared receiving batter (25) provided with near-infrared
Manage (27)；Described near-infrared receiving chamber (29) is connected provided with circuit board (28) with near-infrared receiving closed tube (27)；Described dialysis
Liquid passage (24) is exported with dialyzer (4) dialyzate or dialyzate outlet line (13) is connected and is transported to used dialyzate returns
Receive bucket (15)；
Connector (23) is provided with outside described probing shell (21), the connector (23) connects near red by wire guide (22)
Outer receiving chamber (29), near infrared emission room (32) and outside；Described dialyzate passage (24) is covered provided with quartz glass (33)
Near-infrared receiving batter (25) and near infrared emission hole (30)；Described dialyzate monitoring probe (14) also includes two closures
(26) connection probing shell (21), forms near-infrared receiving chamber (29) and near infrared emission room (32) respectively；
Dialyzate near infrared light monitoring dialyzate passage (24), the spectral signal of collection is through dialyzate monitoring probe (14)
Inner lead is drawn by connector (23) from conduit, detects that data circuit (16), near infrared spectrum are supervised through near infrared spectrum
Instrument (17) is surveyed to obtain in hemodialysis dialyzate urea nitrogen content and record in real time.
7. urea nitrogen content on-line monitoring system in hemodialysis dialyzate according to claim 6, it is characterised in that：
Described closure (26) is threadedly coupled with probing shell (21) by sealing.
8. urea nitrogen content on-line monitoring system in hemodialysis dialyzate according to claim 6, it is characterised in that：
Described connector (23), probing shell (21) and closure (26) uses stainless steel.
9. urea nitrogen content on-line monitoring system in hemodialysis dialyzate according to claim 6, it is characterised in that：
Dialyzate in described near infrared light normal transmission dialyzate passage (24).
10. urea nitrogen content on-line monitoring system in hemodialysis dialyzate according to claim 2, it is characterised in that：
Urea nitrogen content on-line monitoring system is arranged on arterial circulation provided with heparin pump (20) in described hemodialysis dialyzate
On conduit (3)；The parenteral solution of preparation injects blood through heparin pump (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710284675.7A CN106970043B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for urea nitrogen content in hemodialysis dialysate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710284675.7A CN106970043B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for urea nitrogen content in hemodialysis dialysate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106970043A true CN106970043A (en) | 2017-07-21 |
| CN106970043B CN106970043B (en) | 2023-08-11 |
Family
ID=59332664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710284675.7A Active CN106970043B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for urea nitrogen content in hemodialysis dialysate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106970043B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998019592A1 (en) * | 1996-11-01 | 1998-05-14 | Rio Grande Medical Technologies, Inc. | Dialysis monitoring method and apparatus |
| CN2386827Y (en) * | 1998-09-11 | 2000-07-12 | 彭罗民 | Automatic blood dialyser |
| WO2013025844A2 (en) * | 2011-08-16 | 2013-02-21 | Medtronic, Inc. | Modular hemodialysis system |
| CN105473170A (en) * | 2013-09-02 | 2016-04-06 | 日机装株式会社 | Blood purifier |
-
2017
- 2017-04-26 CN CN201710284675.7A patent/CN106970043B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998019592A1 (en) * | 1996-11-01 | 1998-05-14 | Rio Grande Medical Technologies, Inc. | Dialysis monitoring method and apparatus |
| CN2386827Y (en) * | 1998-09-11 | 2000-07-12 | 彭罗民 | Automatic blood dialyser |
| WO2013025844A2 (en) * | 2011-08-16 | 2013-02-21 | Medtronic, Inc. | Modular hemodialysis system |
| CN105473170A (en) * | 2013-09-02 | 2016-04-06 | 日机装株式会社 | Blood purifier |
Non-Patent Citations (2)
| Title |
|---|
| 尹良红,罗远辉,刘娜,郑慧渊,郑绮宜: "国产血透机与进口血透机性能比较" * |
| 胥凌兰;杨娟;曾晶;: "在线尿素清除率监测效果评估" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106970043B (en) | 2023-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10179199B2 (en) | Medical apparatus for extracorporeal blood treatment and method for determining a blood parameter value in a medical apparatus thereof | |
| EP3111211B1 (en) | Self calibrating blood chamber | |
| US20070284298A1 (en) | Plasma extraction apparatus | |
| CN207147968U (en) | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis blood | |
| CN206710304U (en) | Urea nitrogen creatinine content on-line monitoring system in a kind of hemodialysis dialyzate | |
| CN206804517U (en) | Creatinine content on-line monitoring system in a kind of hemodialysis blood | |
| CN106983923A (en) | Urea nitrogen content on-line monitoring method and system in a kind of hemodialysis blood | |
| CN105517490B (en) | Full-automatic citric acid partially anti-freezing function machine | |
| CN106918573A (en) | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CA2268519A1 (en) | System and method for noninvasive hemodynamic measurements in hemodialysis shunts | |
| CN106970043A (en) | Urea nitrogen content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CN106990068A (en) | Urea nitrogen creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CN106896082A (en) | Urea nitrogen creatinine content on-line monitoring method and system in a kind of hemodialysis blood | |
| CN109856381A (en) | A kind of division of endocrinology's diabetes fast testing apparatus | |
| CN106908410A (en) | Creatinine content on-line monitoring method and system in a kind of hemodialysis blood | |
| CN207101561U (en) | A kind of haemodialyser for the detectable liquid level being easily installed | |
| CN109234152A (en) | A kind of circulating tumor cell separator | |
| CN205386255U (en) | Bioartificial liver pipe -line system | |
| CN107561038A (en) | Creatinine content on-line monitoring method and system in a kind of hemodialysis dialyzate | |
| CN110530824A (en) | A kind of osmotic fragility measuring method and its kit | |
| TWI678214B (en) | Blood analysis module and blood collection device | |
| CN205460109U (en) | Multi -functional ECMO circulating line | |
| CN108325007A (en) | A kind of system and method by expiration dynamic monitoring haemodialysis | |
| CN107884563A (en) | A kind of medical treatment device and its application method for blood analysis | |
| CN113694280A (en) | Method for monitoring toxin content distribution in-vitro dialyzer in real time |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |