CN106955306A - A kind of traditional Chinese medicine for treating cub diarrhoea and preparation method thereof - Google Patents
A kind of traditional Chinese medicine for treating cub diarrhoea and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K36/76—Salicaceae (Willow family), e.g. poplar
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention belongs to veterinary drug technical field, and in particular to a kind of traditional Chinese medicine for treating cub diarrhoea and preparation method thereof.The present invention is made up of the bulk drug of following weight ratio：15 25 parts of honeysuckle, 15 25 parts of tree of heaven ailanthus bark, 15 25 parts of huangteng, 10 13 parts of the root of large-flowered skullcap, 10 15 parts of polygonum flaccidum, 10 12 parts of the capsule of weeping forsythia, 10 12 parts of poplar flower, 5 10 parts of Aplotaxis auriculata.Contain huangteng, honeysuckle and poplar flower in traditional Chinese medicine of the present invention, there are good restraining and sterilizing bacteria and antiviral functions after being applied in combination, and functionally form synergy and complementation, Escherichia coli, staphylococcus, salmonella to causing scouring, streptococcus, shigella dysenteriae, typhoid bacillus etc. have stronger bacteriostasis.
Description
Technical field
The invention belongs to field of veterinary, more particularly to a kind of traditional Chinese medicine for treating cub diarrhoea and preparation method thereof.
Background technology
With the improvement of people's living standards, requirement of the people to dairy stock meat product also more and more higher, is used in animal husbandry
Animal drug must be pollution-free, noresidue, efficient green medicine.
Traditional Chinese medicine refers to the active ingredient extracted from Chinese medicine, using modern science and technology and method be made can
It is made into for being injected in vivo the sterile solution used including muscle, acupuncture point, intravenous injection and drip-feed, suspension, or before use
Aseptic powdery of liquid etc. injects the preparation of human body.Drug effect is rapid, and dosage is small, reliable effect, it is adaptable to unsuitable oral medicine
Thing.
Scouring is one of most common disease, the incidence of disease and height on veterinary clinic, and its pathogenesis is more, mainly has
Coli-infection, viral infection, enteritis, indigestion, feed reason etc. cause.Clinically multiplex antibiotic and chemicals
Treated, because the cause of disease is complicated, offer limited effectiveness easily triggers drug resistance and other side effects.Traditional Chinese medicine is by adjusting machine
Body whole body function, plays the disease-resistant purpose cured the disease, sick difficulty in relapse after healing, and have no drug resistance generation.So, exploitation treatment cub abdomen
The traditional Chinese medicine rushed down has certain superiority.
The content of the invention
For above shortcomings in the prior art, it is an object of the invention to provide a kind of aobvious to scouring curative effect
Write, healing time is short, and have no toxic side effect the traditional Chinese medicine having no drug resistance.
The present invention is to be achieved through the following technical solutions above-mentioned purpose：A kind of traditional Chinese medicine for treating cub diarrhoea,
It is made up of the bulk drug of following weight ratio：15-25 parts of honeysuckle, 15-25 parts of tree of heaven ailanthus bark, 15-25 parts of huangteng, root of large-flowered skullcap 10-13
Part, 10-15 parts of polygonum flaccidum, 10-12 parts of the capsule of weeping forsythia, 10-12 parts of poplar flower, 5-10 parts of Aplotaxis auriculata.
Further, it is made up of the bulk drug of following weight ratio：20 parts of honeysuckle, 20 parts of tree of heaven ailanthus bark, 20 parts of huangteng, Huang
12 parts of a kind of reed mentioned in ancient books, 13 parts of polygonum flaccidum, 11 parts of the capsule of weeping forsythia, 11 parts of poplar flower, 8 parts of Aplotaxis auriculata.
Above-mentioned traditional Chinese medicine is prepared by following methods：
1）Preextraction：Above-listed bulk drug was ground into meal, with water wash 5-10 minutes, add water not powder, adjust PH to 1.0
~2.0, stand, filtering adds purified water to appropriate, heating is boiled, and collects decoction, adjusts PH to 8.0~8.5, heating is boiled,
Collect in the decoction extracted twice before decoction is incorporated to.
2）Concentration, purifying：Will be through step 1）Decoction after preextraction is concentrated under reduced pressure, add ethanol in proper amount adjust alcoholic strength to
65~70 degree, PH to 4.5~6.5 is adjusted, is stood, supernatant liquid filtering is taken, ethanol is reclaimed, then alcohol precipitation purifying is carried out once with method,
Reclaim the mixed extract that above-listed bulk drug is made after ethanol.
3）Prepare injection：Learn from else's experience step 2）Bulk drug mixed extract after processing, adds water for injection to recipe quantity,
PH to 4.8~5.2 is adjusted, appropriate needle-use activated carbon is added, stirring takes off charcoal, after secondary filter, is filled into glass ampoule bottles
In, traditional Chinese medicine is made in sealing, autoclaving.
Further, water described in step 1 is purified water.
Further, pH value is adjusted with 10% sodium hydroxide solution or 10% sulfuric acid solution in step 2.
Further, secondary filter is used through 0.45 micron of filter material secondary filter in step 3.
Further, the sterilizing of step 3 mesohigh was using 115 DEG C of autoclavings 30 minutes.
Compared with prior art, the beneficial effects of the invention are as follows：
1st, contain huangteng, honeysuckle and poplar flower in traditional Chinese medicine of the present invention, there is antibacterial well kill after being applied in combination
Bacterium and antiviral functions, and functionally form synergy and complementation, to cause the Escherichia coli of scouring, staphylococcus,
Salmonella, streptococcus, shigella dysenteriae, typhoid bacillus etc. have stronger bacteriostasis.
2nd, contain tree of heaven ailanthus bark, polygonum flaccidum in traditional Chinese medicine of the invention, relieving diarrhea with astringents and controlling for stopping blooding are made after being applied in combination
Therapeutic effect is remarkably reinforced, and duration of efficacy extends, and gastrointestinal tract inflammation position and ulcer surface can be made to obtain fast quick-recovery, controlled
More the time substantially shortens.
3rd, contain Aplotaxis auriculata in traditional Chinese medicine of the invention, can warming middle-JIAO for easing the stomach, regulating qi-flowing for relieving pain, reconcile stomach, inducing diaphoresis and remove
It is wet, recover body autoimmune function, improve the absorption rate of medicine.
Make it that each efficacy of drugs produces synergy after present invention selection drug regimen, to diseases such as scouring, diarrheas,
Synthetic is carried out in terms of antibacterial, sterilized, antiviral and convergence, relieving diarrhea with astringents, hemostasis and middle benefit gas stomach invigorating, regulating qi-flowing for relieving pain etc. three
Treat and nurse one's health, reach the effect treated both principal and secondary aspect of disease, not only evident in efficacy, cure rate is high, and utilization ratio of drug is high, and healing time is short, former
Material is easy to get, simple production process, with low cost, and bulk drug of the present invention with plant homologous, consubstantiality, be general chemical drugs
Product, antibiotic, hormone medicine etc. are incomparable, and its metabolite directly can be absorbed or be excreted by animal, without residual
Stay, have no drug resistance, and environment will not be caused harm.
The pharmacological effect of each component of the present invention is as follows：
1st, honeysuckle has effects that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treat wind.Cure mainly disease under turgor, warm disease heating, heat toxin large carbuncle and
The diseases such as tumour.
2nd, tree of heaven ailanthus bark, it is bitter in taste, cold, puckery, with except heat, eliminating dampness, puckery intestines, hemostasis, desinsection special efficacy.To enteritis, dysentery characterized by blood in the stool,
The alimentary canal inflammatory disease such as enterorrhagia has good effect.Heat-clearing and damp-drying drug, puckery intestines, hemostasis, stop-band, desinsection, main diarrhea, dysentery is had blood in stool, collapsed
Under leakage, hemorrhoid hemorrhage, band, ascariasis, sore tinea.Channel tropism：Stomach；Large intestine；The heart；Liver；Spleen；Lung channel.
3rd, huangteng has effects that clearing heat and detoxicating, anti-inflammation, antiviral, diuresis, the large intestine to causing scouring
The various bacterias such as bacillus, staphylococcus, streptococcus, shigella dysenteriae, typhoid bacillus and virus have stronger bacteriostasis.
4th, the root of large-flowered skullcap have heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, it is antiabortive the effects such as.Cure mainly warm heat disease, the infection of the upper respiratory tract,
The diseases such as cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swells furuncle sore.
5th, polygonum flaccidum has effects that dry antidiarrheal, blood stasis removing analgesic, wind-dispelling, pesticide-germicide, cures mainly dysentery stomachache, cold intestines and lets out
Rush down, the symptom such as dysentery of trembling with fear.
6th, the capsule of weeping forsythia has heat-clearing, removing toxic substances, dissipating bind, detumescence.Control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching
Close.
7th, poplar flower has effects that clearing heat and detoxicating, dampness elimination stop dysentery.To bacillary dysentery, virus diarrhea and intestines problem
There is significant curative effect, can effectively prevent and treat domestic animal Escherichia coli, salmonella, duck Pasteurella, proteus, staphylococcus etc. a variety of
Domestic animal infection of digestive canal caused by bacterium and virus.
8th, Aplotaxis auriculata has promoting qi circulation and relieving pain, effect of warming middle-JIAO for easing the stomach.Chest and abdomen swelling and pain is cured mainly, is vomitted, diarrhea, in dysentery after urgency
Weight.
The usage and consumption of the present invention：
Application method is to pass through related acupoint injection therapy（Such as increase food cave, Re equilibrium, hand over the related acupoint injection therapy of nest, have sharp ears）, often
It is it 1~2 time, general continuously to use 4 days.Consumption is each time：Calf is per 0.05~0.20ml of 1kg body weight；Piglet is per 1kg body weight
0.15~0.20ml.
Embodiment
The present invention is expanded on further below by way of specific embodiment, but is not limited to following embodiments.
Embodiment 1
A kind of traditional Chinese medicine for treating cub diarrhoea, is made up of the bulk drug of following weight ratio：20 parts of honeysuckle, tree of heaven ailanthus bark 20
Part, 20 parts of huangteng, 12 parts of the root of large-flowered skullcap, 13 parts of polygonum flaccidum, 11 parts of the capsule of weeping forsythia, 11 parts of poplar flower, 8 parts of Aplotaxis auriculata, the traditional Chinese medicine by
Following methods are prepared：
1）Preextraction：After above-mentioned Chinese medicine material is mixed, the meal of 25 mesh sieves was ground into, Multifunctional pot for extracting Chinese medicine is placed in
It is interior, do not had powder with purifying water wash 5~10 minutes, plus purified water, PH to 1.0~2.0 is adjusted with 10% sulfuric acid solution, stood
12 hours, add appropriate purified water, heating boils 2 times, 30 minutes every time, it is standby to collect decoction, after again plus purified water did not had
Powder, PH to 8.0~8.5 is adjusted with 10% sodium hydroxide solution, and heating is boiled 30 minutes, is collected before decoction is incorporated to and is extracted twice
In decoction.
2）Concentration, purifying：Will be through step 1）Decoction after preextraction is concentrated under reduced pressure into one of five parts of stoste, adds appropriate
Ethanol adjust alcoholic strength to 65 degree or 70 degree, with 10% sodium hydroxide solution or 10% sulfuric acid solution regulation PH to 4.5~6.5,5~
24 hours are stood at 8 DEG C, supernatant liquid filtering is taken, ethanol is reclaimed, then alcohol precipitation purifying is carried out once with method, is produced after reclaiming ethanol
State the mixed extract of 7 taste Chinese medicines.
3）Prepare injection：Learn from else's experience step 2）Chinese medicine mixed extract after processing, injects water to recipe quantity, uses
10% sodium hydroxide solution or 10% sulfuric acid solution regulation PH to 4.8~5.2, add appropriate needle-use activated carbon, stir 15 minutes, take off
Charcoal, after 0.45 micron of filter material secondary filter, is filled into 10ml glass ampoule bottles, sealing, 115 DEG C of autoclavings 30 minutes,
The traditional Chinese medicine for being available for animal injection to use is made.
Embodiment 2
A kind of traditional Chinese medicine for treating cub diarrhoea, is made up of the bulk drug of following weight ratio：15 parts of honeysuckle, tree of heaven ailanthus bark 15
Part, 15 parts of huangteng, 10 parts of the root of large-flowered skullcap, 10 parts of polygonum flaccidum, 10 parts of the capsule of weeping forsythia, 10 parts of poplar flower, 5 parts of Aplotaxis auriculata, the traditional Chinese medicine by
Following methods are prepared：
1）Preextraction：After above-mentioned Chinese medicine material is mixed, the meal of 25 mesh sieves was ground into, Multifunctional pot for extracting Chinese medicine is placed in
It is interior, do not had powder with purifying water wash 5~10 minutes, plus purified water, PH to 1.0~2.0 is adjusted with 10% sulfuric acid solution, stood
12 hours, add appropriate purified water, heating boils 2 times, 30 minutes every time, it is standby to collect decoction, after again plus purified water did not had
Powder, PH to 8.0~8.5 is adjusted with 10% sodium hydroxide solution, and heating is boiled 30 minutes, is collected before decoction is incorporated to and is extracted twice
In decoction.
2）Concentration, purifying：Will be through step 1）Decoction after preextraction is concentrated under reduced pressure into one of five parts of stoste, adds appropriate
Ethanol adjust alcoholic strength to 65 degree or 70 degree, with 10% sodium hydroxide solution or 10% sulfuric acid solution regulation PH to 4.5~6.5,5~
24 hours are stood at 8 DEG C, supernatant liquid filtering is taken, ethanol is reclaimed, then alcohol precipitation purifying is carried out once with method, is produced after reclaiming ethanol
State the mixed extract of 7 taste Chinese medicines.
3）Prepare injection：Learn from else's experience step 2）Chinese medicine mixed extract after processing, injects water to recipe quantity, uses
10% sodium hydroxide solution or 10% sulfuric acid solution regulation PH to 4.8~5.2, add appropriate needle-use activated carbon, stir 15 minutes, take off
Charcoal, after 0.45 micron of filter material secondary filter, is filled into 10ml glass ampoule bottles, sealing, 115 DEG C of autoclavings 30 minutes,
The traditional Chinese medicine for being available for animal injection to use is made.
Embodiment 3
A kind of traditional Chinese medicine for treating cub diarrhoea, is made up of the bulk drug of following weight ratio：25 parts of honeysuckle, tree of heaven ailanthus bark 25
Part, 25 parts of huangteng, 13 parts of the root of large-flowered skullcap, 15 parts of polygonum flaccidum, 12 parts of the capsule of weeping forsythia, 12 parts of poplar flower, 10 parts of Aplotaxis auriculata, the traditional Chinese medicine by
Following methods are prepared：
1）Preextraction：After above-mentioned Chinese medicine material is mixed, the meal of 25 mesh sieves was ground into, Multifunctional pot for extracting Chinese medicine is placed in
It is interior, do not had powder with purifying water wash 5~10 minutes, plus purified water, PH to 1.0~2.0 is adjusted with 10% sulfuric acid solution, stood
12 hours, add appropriate purified water, heating boils 2 times, 30 minutes every time, it is standby to collect decoction, after again plus purified water did not had
Powder, PH to 8.0~8.5 is adjusted with 10% sodium hydroxide solution, and heating is boiled 30 minutes, is collected before decoction is incorporated to and is extracted twice
In decoction.
2）Concentration, purifying：Will be through step 1）Decoction after preextraction is concentrated under reduced pressure into one of five parts of stoste, adds appropriate
Ethanol adjust alcoholic strength to 65 degree or 70 degree, with 10% sodium hydroxide solution or 10% sulfuric acid solution regulation PH to 4.5~6.5,5~
24 hours are stood at 8 DEG C, supernatant liquid filtering is taken, ethanol is reclaimed, then alcohol precipitation purifying is carried out once with method, is produced after reclaiming ethanol
State the mixed extract of 7 taste Chinese medicines.
3）Prepare injection：Learn from else's experience step 2）Chinese medicine mixed extract after processing, injects water to recipe quantity, uses
10% sodium hydroxide solution or 10% sulfuric acid solution regulation PH to 4.8~5.2, add appropriate needle-use activated carbon, stir 15 minutes, take off
Charcoal, after 0.45 micron of filter material secondary filter, is filled into 10ml glass ampoule bottles, sealing, 115 DEG C of autoclavings 30 minutes,
The traditional Chinese medicine for being available for animal injection to use is made
With traditional Chinese medicine made from the present embodiment by long-term stable experiments such as illumination, low temperature, room temperature, high temperature, product is clear
Clear to change without discoloration, precipitation etc., product quality is stable.
Domestic animal bacillary enteritis discontinuity diarrhoea, virus diarrhea, stream are cured mainly with traditional Chinese medicine made from the present embodiment
The various malignant diarrheas of row diarrhoea and unknown cause.Application method is to pass through related acupoint injection therapy（Such as increase food cave, Re equilibrium,
Hand over the related acupoint injection therapy such as nest, have sharp ears）, it is daily 1~2 time, general continuously to use 4 days.Consumption is each time：Calf is per 1kg
0.05~0.20ml of body weight；Piglet is per 0.15~0.20ml of 1kg body weight.
Clinical test：Concept clinical controlling experiment.Represented by medication of piglet, clinical diarrhoea case is collected, by 15ml/
10-15kg body weight is administered, related acupoint injection therapy, 1 times/day, and after general medication 1-2 times, the state of an illness is clearly better, extensive after 3 times
Multiple normal, be not in a bad way individually person, after medication 4-5 times, can cure or take a turn for the better.Preliminary test shows that the medicine is to piglet abdomen
Rush down with good result, especially prevent and treat grice diarrhoea caused by abiotic factor efficient up to more than 95%, cure rate 86%
More than.
Presently preferred embodiments of the present invention is the foregoing is only, is not the whole embodiments of the present invention, not to limit
The system present invention, within the spirit and principles of the invention, any modifications, equivalent substitutions and improvements made etc. should be included in
Within protection scope of the present invention.
In addition to technical characteristic described in specification, remaining technical characteristic is technology known to those skilled in the art, in order to prominent
Go out the innovative characteristicses of the present invention, above-mentioned technical characteristic will not be repeated here.
Claims (7)
1. a kind of traditional Chinese medicine for treating cub diarrhoea, it is characterised in that be made up of the bulk drug of following weight ratio：Gold and silver
15-25 parts of flower, 15-25 parts of tree of heaven ailanthus bark, 15-25 parts of huangteng, 10-13 parts of the root of large-flowered skullcap, 10-15 parts of polygonum flaccidum, 10-12 parts of the capsule of weeping forsythia, poplar
Tree flower 10-12 parts, 5-10 parts of Aplotaxis auriculata.
2. the traditional Chinese medicine for the treatment of cub diarrhoea according to claim 1, it is characterised in that by following weight ratio
Bulk drug is made：20 parts of honeysuckle, 20 parts of tree of heaven ailanthus bark, 20 parts of huangteng, 12 parts of the root of large-flowered skullcap, 13 parts of polygonum flaccidum, 11 parts of the capsule of weeping forsythia, poplar flower
11 parts, 8 parts of Aplotaxis auriculata.
3. the preparation method of the traditional Chinese medicine for the treatment of cub diarrhoea according to claim 1 or 2, it is characterised in that bag
Include following steps：
1）Preextraction：Above-listed bulk drug was ground into meal, with water wash 5-10 minutes, add water not powder, adjust PH to 1.0
~2.0, stand, filtering adds purified water to appropriate, heating is boiled, and collects decoction, adjusts PH to 8.0~8.5, heating is boiled,
Collect in the decoction extracted twice before decoction is incorporated to.
2）Concentration, purifying：Will be through step 1）Decoction after preextraction is concentrated under reduced pressure, and addition ethanol in proper amount regulation alcoholic strength to 65~
70 degree, PH to 4.5~6.5 is adjusted, is stood, supernatant liquid filtering is taken, ethanol is reclaimed, then alcohol precipitation purifying is carried out once with method, is reclaimed
The mixed extract of above-listed bulk drug is made after ethanol.
3）Prepare injection：Learn from else's experience step 2）Bulk drug mixed extract after processing, adds water for injection to recipe quantity, regulation
PH to 4.8~5.2, adds appropriate needle-use activated carbon, and stirring takes off charcoal, after secondary filter, is filled into glass ampoule bottles, melts
Traditional Chinese medicine is made in envelope, autoclaving.
4. the preparation method of the traditional Chinese medicine for the treatment of cub diarrhoea according to claim 3, it is characterised in that step 1
Described in water be purified water.
5. the preparation method of the traditional Chinese medicine for the treatment of cub diarrhoea according to claim 3, it is characterised in that step 2
It is middle to adjust pH value with 10% sodium hydroxide solution or 10% sulfuric acid solution.
6. the preparation method of the traditional Chinese medicine for the treatment of cub diarrhoea according to claim 3, it is characterised in that step 3
Middle secondary filter is used through 0.45 micron of filter material secondary filter.
7. the preparation method of the traditional Chinese medicine for the treatment of cub diarrhoea according to claim 3, it is characterised in that step 3
Mesohigh sterilizing was using 115 DEG C of autoclavings 30 minutes.
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| CN102895355A (en) * | 2012-11-07 | 2013-01-30 | 大理金明动物药业有限公司 | Chinese medicinal injection for treating livestock diarrhea and preparation method thereof |
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Application publication date: 20170718 |