CN106942266A - Compound decis preparation and its preparation method and application and the muscicide comprising it - Google Patents
Compound decis preparation and its preparation method and application and the muscicide comprising it Download PDFInfo
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- CN106942266A CN106942266A CN201710200930.5A CN201710200930A CN106942266A CN 106942266 A CN106942266 A CN 106942266A CN 201710200930 A CN201710200930 A CN 201710200930A CN 106942266 A CN106942266 A CN 106942266A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
- A01N43/26—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
- A01N43/28—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
- A01N43/30—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3 with two oxygen atoms in positions 1,3, condensed with a carbocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
- A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
Abstract
Muscicide the invention provides compound decis preparation and its preparation method and application and comprising it.In compound decis preparation of the present invention, by the way that by decis and bromine cyanogen insect amide compounding use, fly effect is killed so as to effectively improve；Meanwhile, the compound decis preparation longevity of residure of the present invention is short, will not produce toxic action to letting animals feed；Further, invention formulation environmental protection is also caused as solvent using biodiesel.Meanwhile, it is easy with preparation method step by the order mixing of each raw material to prepare compound decis preparation in the inventive method, it is easy to the advantages of large-scale industrial production.Further, invention formulation, which has, good kills fly effect, it is thus possible to be further used for killing fly, fly blow and larva, and prepares corresponding insecticide, and good fly and the effect to environmental Kuznets Curves are killed while can also play.
Description
Technical field
The present invention relates to pesticidal agents field, in particular to compound decis preparation and preparation method thereof and should
With and comprising its muscicide.
Background technology
With the development of China's animal husbandry, intensive livestock and poultry cultivation produces being on the increase for field.However, because some are smaller
The harmless treatment of farm animal excrement is not focused in the individual breeding production field of type, along with the plant that has again from residential block compared with
Closely, so that livestock and poultry farm is on the rise to the pollution level of surrounding environment, and multiplying for harmful organism is caused, fly is exactly it
It is middle a kind of to endanger more serious growth insect.
Fly is a kind of highly unwanted insect, and it is distributed extensively, and reproductive capacity is strong.In torrid areas, every female fly once can
Produce 100~200 offsprings, if temperature, humidity are suitable, from ovum to adult need only 5~10d development time.Livestock and poultry are distributed in support
It is house fly, wild housefly and black housefly etc. mostly to grow in field.Fly likes hot and humid, is suitable for 25 DEG C~35 DEG C, wet
Degree 85%~90%, it is generally rubbish heap, manure pit, lavatory, animal house, animal wastes, corrupt organic matter to grow source.The harm of fly
Very big, it not only pollutes animal feed, and pollution drinking-water influences environmental sanitation, while livestock and poultry rest is can also interfere with, reduction animal life
Performance is produced, more seriously it can also propagate livestock and poultry.It is reported that fly can propagate cholera, typhoid fever, paratyphoid, dysentery
Tens of kinds of human and animal's diseases such as disease, salmonellosis, angstrom Xi Shi colibacillosis, leptospirosis, this is strong to human body
Health is also great threatens.
Decis (Deltamethrin) also known as decis, benzonitrile chrysanthemum ester, flutter that worm is net, overcome the enemy, or Kang Suling, category the
The representative of three generations's pyrethroid insecticides, it is put into national key new product plan catalogue in 2000.Bromine cyanogen insect amide
(Cyantraniliprole) it is a kind of E.I.Du Pont Company's anthranilamide-based insecticide in recent years newly developed, belongs to the second generation
Ryanodine receptor inhibitor insecticides, it has excellent preventive effect to sucking pest, had broad application prospects.
The combination of decis and bromine cyanogen insect amide has efficient, low toxicity, mechanism of action novelty, to non-target organism safety, to existing
Many advantages, such as insecticide no interactions resistance, especially there is prominent effect on to control fly, can not only kill fly, may be used also
To kill fly blow and larva.
At present, the most livestock and poultry farms of in the market are big with the animal toxicity of combination decis product, kill fly drug effect and hold
The continuous time is short, and easily pollutes animal and fowl fodder.Livestock and poultry die like a rat caused by the use of muscicide accident also when have hair
It is raw；Meanwhile, existing most products use toluene, dimethylbenzene etc. as organic solvent, so there is very big pollution to environment.
In the prior art, also there is certain research for decis preparation, but existing decis preparation has one
Fixed defect.For example, patent (CN1530012A) discloses a kind of decis microemulsion and its production method, by a variety of
Solvent, emulsifying agent, the screening and research of preparation technology, replace a large amount of organic solvents, then add suitable surfactant, help with water
Agent, the decis microemulsion prepared is processed by micronization.The invention product stability is poor, and microemulsion belongs to thermodynamically
Unsteady dispersion, by a variety of such environmental effects.In addition this method is mainly crop insecticides, and fly is killed to livestock and poultry
Effect is bad, and the complex process, high cost.
Meanwhile, it is DDVP and the compounded cream of decis that patent (CN101695303A), which discloses a kind of active ingredient,
Preparation, is made up of DDVP, decis, emulsifying agent, cosolvent and organic solvent.DDVP is answered with decis in this method
After matching somebody with somebody, although stomach toxicity can be strengthened and efficiency of tagging, but only have enhancing drug effect to crop pest, not verify the effect to killing fly
Really.In addition this method makees organic solvent using dimethylbenzene, and dimethylbenzene has very big harm to environment and livestock and poultry.
Patent (US669313) discloses a kind of preparation method of the water-dispersible granules of decis, and the patent is related to
Preparation is made up of wetting agent, dispersant, solid inert material and one or more acid (being used for modulator pH value to 1~7).This is special
Insect of the sharp preparation suitable for preventing and treating crop protection, be not suitable for livestock and poultry farm kills fly.In addition this method preparation is given birth to
Production. art is complicated, and production cost is high.
Patent (US20140170199) discloses a kind of decis and indoxacarb combination insecticide preparation method, and this is special
Wherein the ratio of indoxacarb and decis is 1 in profit：10~10：1 is combined.The proprietary preparation is to acaricidal activity and guarantor
Holding the constant drug effect of confrontation parasitic insect such as flea has excellent effect, while stressing to have carried out effect experiment on dog, not
Do the experiment in terms of killing fly.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of compound decis preparation, described compound decis preparation
In, by the way that by decis and bromine cyanogen insect amide compounding use, fly effect is killed so as to effectively improve；Meanwhile, compound bromine of the present invention
The Cyano chrysanthemate preparation longevity of residure is short, will not produce toxic action to letting animals feed；Further, this is also caused using biodiesel as solvent
Invention preparation environmental protection.
The second object of the present invention is to provide a kind of preparation method of the compound decis preparation, the inventive method
In, it is easy with preparation method step, it is easy to large-scale industry by the order mixing of each raw material to prepare compound decis preparation
The advantages of metaplasia is produced.
Third object of the present invention is to provide the application of the compound decis preparation, and invention formulation has good
Good kills fly effect, it is thus possible to be further used for killing fly, fly blow and larva.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of compound decis preparation, according to percent by weight, the compound decis preparation is main by following
Component is made：
Decis 1.0~30.0%, emulsifying agent 1.0~30.0%, synergist 1.0~30.0%, stabilizer 1.0~
10.0%, and biodiesel 10.0~90.0%.
Optionally, in the present invention, according to percent by weight, the compound decis preparation is main by following components system
Into：
Decis 5.0~20.0%, bromine cyanogen insect amide 1.0~5.0%, emulsifying agent 4.0~30.0%, synergist 5.0
~20.0%, stabilizer 3.0~7.0%, and biodiesel 20.0~80.0%.
Optionally, in the present invention, the emulsifying agent is Tween-80, Crodaret, nonyl phenol gather
Oxygen vinethene, and one kind or any two kinds of blended emulsifier in APES；
It is preferred that, the emulsifying agent is the blended emulsifier of Tween-80 and Crodaret.
Optionally, in the present invention, the synergist is one kind in piperonyl butoxide, Octachlorodipropyl Ether, or Octacide 264
Or any two kinds of synergistic blend agent；
It is preferred that, the synergist is the synergistic blend agent of piperonyl butoxide and Octachlorodipropyl Ether.
Optionally, in the present invention, the stabilizer is in dimethylformamide, ethylene glycol, isopropanol, or phenmethylol
One or more mixed stabilizers；
It is preferred that, the stabilizer is phenmethylol.
Optionally, in the present invention, the mass ratio of decis and bromine cyanogen insect amide is (3~5)：1；
It is preferred that, the mass ratio of decis and emulsifying agent is 1：(2~3)；
It is preferred that, the mass ratio of decis and synergist is (1~2)：(1~2).
Meanwhile, present invention also offers the preparation method of the compound decis preparation, its methods described includes as follows
Step：
Decis and bromine cyanogen insect amide are added in emulsifying agent and synergist, and heating stirring dissolves；Then life is added
Thing diesel oil and stabilizer, heating stirring mixing, cooling filtering produce the compound decis preparation.
Optionally, in the present invention, methods described is additionally added bromine cyanogen insect amide while being additionally included in addition decis
Step.
Further, present invention also offers the compound decis preparation in fly, fly blow and larva is killed
Application.
Similarly, present invention also offers the muscicide for including compound decis preparation of the present invention.
Compared with prior art, beneficial effects of the present invention are：
(1) decis of the present invention and bromine cyanogen insect amide combination oil emu have it is single-minded kill fly property, to fly, fly blow and
Larva has significant contact efficacy, at the same it is safe, environment and animal and fowl fodder will not be polluted.
(2) decis of the present invention and bromine cyanogen insect amide combination oil emu insecticidal activity are high, and the longevity of residure is short, can be quick
The effect of control fly is reached, invasion of the fly to transmission of disease and to livestock and poultry is reduced.
(3) decis of the present invention and bromine cyanogen insect amide combination oil emu are easy to use, can be directly equal after diluting in proportion
Even to splash in livestock and poultry farm, medicine is easy to dispersed, and security is good, and desinsection is thorough.
(4) decis of the present invention and bromine cyanogen insect amide combination oil emu select Novel synergistic agent, during drug action
Between increase, accomplish that thorough root kills fly, and be not likely to produce drug resistance.
(5) decis of the present invention and bromine cyanogen insect amide combination oil emu select green solvent biodiesel, Small side effects,
The pollution to environment periphery is reduced, does not trigger drug induced disease.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or the unreceipted production firm person of instrument, are
The conventional products that can be obtained by commercially available purchase.
Decis provided by the present invention and bromine cyanogen insect amide combination oil emu, are that a kind of special livestock and poultry farm is killed
Fly agent.Compared with existing proprietary preparation, livestock and poultry farm fly, fly blow and larva are killed in the synergy of invention formulation energy, kill grey
Fly excellent effect；Meanwhile, solvent, thus Small side effects, low cost are done using biodiesel；Science screening formula, good stability,
Easy to use, safe concentration is high, is not likely to produce drug resistance, is conducive to the sustainable development of livestock and poultry farm.
Compound decis formulation aesthetics provided by the present invention and performance indications are：1st, appearance character：Orange-yellow clarification
Liquid；2nd, emulsibility：According to the detection of emulsibility inspection technique, occur without layering and precipitate；3rd, moisture content：Surveyed according to aquametry
Fixed, moisture content must not cross 0.30%；4th, density：About 0.960~0.980g/cm3；5th, flash-point：Its sudden strain of a muscle is determined using opening method
Point is more than 40 DEG C (ground is used).
According to percent by weight, compound decis preparation of the present invention is made up of following components：Decis 1.0~
30.0%, for example can be, but be not limited to 5.0,10.0,15.0,20.0, or 25.0% etc.；Emulsifying agent 1.0~30.0%,
It for example can be, but be not limited to 4.0,5.0,10.0,15.0,20.0, or 25.0% etc.；Synergist 1.0~30.0%, for example
It can be, but be not limited to 5.0,10.0,15.0,20.0, or 25.0% etc.；Stabilizer 1.0~10.0%, for example can be,
But it is not limited to 30., 5.0,7.0, or 9.0% etc.；And biodiesel 10.0~90.0%, for example can be, but be not limited to
15th, 18,20,25,30,35,40,50,60,70, or 80% etc.；
In the scheme of the present invention, the compound decis preparation can also be used as second including bromine cyanogen insect amide
Function ingredients, further, raw material components and each component content are as follows in the preparation comprising bromine cyanogen insect amide：Decis 5.0
~20.0%, for example can be, but be not limited to 12,15,18, or 19% etc.；Bromine cyanogen insect amide 1.0~5.0%, for example can be with
For, but it is not limited to 2,3, or 4% etc.；Emulsifying agent 4.0~30.0%, for example can be, but it is not limited to 5,8,10,15,20, or
Person 25% etc.；Synergist 5.0~20.0%, for example can be, but be not limited to 8,10,12,15, or 18% etc.；Stabilizer 3.0
~7.0%, for example can be, but be not limited to 4,5, or 7% etc.；And biodiesel 20.0~80.0%, for example can be,
But it is not limited to 25,30,35,40,50,60, or 75% etc.；
In the preferred scheme of the present invention, the mass ratio of the decis and bromine cyanogen insect amide is (3~5)：
1, for example can be, but be not limited to 3:1、4:1, or 5:1 etc.；
And/or, the mass ratio of decis and emulsifying agent is 1：(2~3), for example can be, but be not limited to 1:2 or 1:
3 etc.；
And/or, the mass ratio of decis and synergist is (1~2)：(1~2), for example can be, but be not limited to 1:1、
1:2, or 2:1 etc.；
In a preferred scheme of the invention, the emulsifying agent is Tween-80 (Tween-80), polyoxyethylene hydrogen
Change castor oil, nonyl phenol polyethenoxy ether (NP-9) and one kind or any two kinds in APES (PO-10)
Blended emulsifier；It is preferred that, the emulsifying agent is the blended emulsifier of Tween-80 and Crodaret,
It is furthermore preferred that Tween-80 (Tween-80) is 1 with the mass ratio of Crodaret:1.25；
In a preferred scheme of the invention, the synergist is piperonyl butoxide, Octachlorodipropyl Ether, or Octacide 264
(MGK-264) one kind or any two kinds of synergistic blend agent in；It is preferred that, the synergist is piperonyl butoxide and eight chlorine two
The synergistic blend agent of propyl ether, it is furthermore preferred that the mass ratio of piperonyl butoxide and Octachlorodipropyl Ether is 1:1；
In a preferred scheme of the invention, the stabilizer is dimethylformamide, ethylene glycol, isopropanol, or
One or more mixed stabilizers in phenmethylol；It is preferred that, the stabilizer is phenmethylol.
The preparation method of compound decis preparation of the present invention comprises the following steps：Decis and bromine cyanogen insect amide are added
Enter in emulsifying agent and synergist, and heating stirring dissolves；In this step, can under 45~50 DEG C of heating condition, with 50~
60rpm mixing speed stirs 1~2h；
Then, biodiesel and stabilizer are added, heating stirring mixing, cooling filtering produces the compound decis
Preparation；In this step, 1~2h can be stirred with 40~50rpm mixing speed, then under 45~50 DEG C of heating condition
20~30 DEG C are cooled to, filtering residue with coarse cloth obtains product compound decis preparation.
Compound decis preparation of the present invention has prominent effect for the prevention and control of fly in plant, can not only kill
Dead fly, additionally it is possible to effectively kill fly blow and screwworm.
Embodiment 1
According to percetage by weight, decis 5.0%, bromine cyanogen insect amide 1.5%, emulsifying agent 10.0%, synergist
5.0%, stabilizer 5.0%, and surplus biodiesel, appropriate each raw material is weighed respectively；
Wherein, the emulsifying agent be Tween-80 (Tween-80) and Crodaret mixture, the two
Mass ratio is 1:1.25；The synergist is the mixture of piperonyl butoxide and Octachlorodipropyl Ether, and the two mass ratio is 1：1；Institute
Stabilizer is stated for benzaldehyde.
Then, in electrical heating stirred autoclave, decis and bromine cyanogen insect amide are added in emulsifying agent and synergist,
Then under 45~50 DEG C of heating condition, 1~2h is stirred with 50~60rpm mixing speed；After stirring and dissolving, continuously add
Biodiesel and stabilizer, then under 45~50 DEG C of heating condition, stir 1~2h, so with 40~50rpm mixing speed
After be cooled to 20~30 DEG C, residue is filtered with coarse cloth, that is, obtains the compound decis preparation of embodiment 1.
The compound decis preparation of embodiment 1 is orange-yellow supernatant liquid, and moisture content is less than 0.20%, and relative density is
0.970 or so, flash-point is higher than 50 DEG C；Meanwhile, according to the detection of emulsibility inspection technique, compound decis preparation is not layered
Or precipitation.
Embodiment 2
According to percetage by weight, decis 2.5%, bromine cyanogen insect amide 5.0%, emulsifying agent 10.0%, synergist
5.0%, stabilizer 5.0%, and surplus biodiesel, appropriate each raw material is weighed respectively；
Wherein, it is identical in emulsifying agent, synergist and the uniform embodiment 1 of stabilizer used in embodiment 2.
Then, the compound decis preparation of embodiment 2 is made according to method described in embodiment 1.
Embodiment 3
According to percetage by weight, decis 7.0%, bromine cyanogen insect amide 1.0%, emulsifying agent 10.0%, synergist
5.0%, stabilizer 5.0%, and surplus biodiesel, appropriate each raw material is weighed respectively；
Wherein, it is identical in emulsifying agent, synergist and the uniform embodiment 1 of stabilizer used in embodiment 3.
Then, the compound decis preparation of embodiment 3 is made according to method described in embodiment 1.
Embodiment 4
According to percetage by weight, decis 5.0%, bromine cyanogen insect amide 1.5%, emulsifying agent 10.0%, synergist
5.0%, stabilizer 5.0%, and surplus biodiesel, appropriate each raw material is weighed respectively；
Wherein, the emulsifying agent is Crodaret and nonyl phenol polyethenoxy ether mixture, the two matter
Amount is than being 1:1.25；The synergist is the mixture of piperonyl butoxide and Octacide 264, and the two mass ratio is 1：1；The stabilization
Agent is dimethylformamide.
Then, the compound decis preparation of embodiment 4 is made according to the methods described of embodiment 1.
Embodiment 5
According to percetage by weight, decis 6.5%, emulsifying agent 10.0%, synergist 5.0%, stabilizer 5.0%, with
And the biodiesel of surplus, appropriate each raw material is weighed respectively；
It is identical in emulsifying agent, synergist and the uniform embodiment 1 of stabilizer used in comparative example 1.
Then, the compound decis preparation of embodiment 5 is prepared according to the methods described of embodiment 1.
Comparative example 1
According to percetage by weight, bromine cyanogen insect amide 6.5%, emulsifying agent 10.0%, synergist 5.0%, stabilizer 5.0%,
And the biodiesel of surplus, appropriate each raw material is weighed respectively；
It is identical in emulsifying agent, synergist and the uniform embodiment 1 of stabilizer used in comparative example 1.
Then, the preparation of comparative example 1 is prepared according to the methods described of embodiment 1.
Experimental example 1
(1) drug substance stable Journal of Sex Research
5.0% decis and 1.5% bromine cyanogen insect amide oil emu product will be contained according to obtained by the method for embodiment 1
As experimental raw, and carry out stability study；And promulgated according to the Ministry of Agriculture《Veterinary chemicals stability study skill
Art guideline (tentative)》Method, using the Accelerated stability test under temperature, three environmental factors of illumination and humidity.
This is tested June in 2016 15 days~No. 26 and carried out at the imperial livestock and poultry drug evaluation center of east Australia, test products by
East Ao Long pharmaceutical Co. Ltds (insecticide GMP certifications production line) produce, and have investigated the stability of three batches of actual production medicines,
Product batch number is respectively 160614,160615,160616.
The stability observing of 5.0% decis and 1.5% bromine cyanogen insect amide oil emu the results are shown in Table 1,2,3.
Stability test observation (the product batch number of the decis of table 1 5.0% and 1.5% bromine cyanogen insect amide oil emu
160614)
Stability test observation (the lot number lot number of the decis of table 2 5.0% and 1.5% bromine cyanogen insect amide oil emu
160615)
Stability test observation (the lot number lot number of the decis of table 3 5.0% and 1.5% bromine cyanogen insect amide oil emu
160616)
From the experimental result data of table 1, table 2 and table 3,0,5,10 days temperature, three environment of illumination and humidity because
Under element, 5.0% decis and appearance character, the relative density of 1.5% bromine cyanogen insect amide oil emu that three batches are produced
(0.960~0.980), emulsibility and content (accounting for labelled amount=90%~110%) meet quality standard.
(2) clinical trial of medicine
This test in No. 1~September of in August, 2,016 30 Zhaoqing Guangdong fine horse it is refined come Hangzhoupro egg chicken house carry out, according to Chinese agriculture
What industry portion was promulgated《Chemical drugs clinical test technological guidance principle (tentative) for animals》Method is tested.
Experimental animal：Carry out Hangzhoupro laying hen (chicken group age in days 195d-220d).
Medicament：The compound decis preparation of embodiment 1 (5.0% decis and 1.5% bromine cyanogen insect amide oil emu, it is raw
Produce lot number 20160720)；
The preparation of embodiment 5 (6.5% decis oil emu)；
The preparation of comparative example 1 (6.5% bromine cyanogen insect amide oil emu).
Size of animal：Same batch, the together hen house of product and size, three hen houses, the A compound decis of embodiment 1
Preparation, B with the preparation of comparative example 1, C obtains chicken number for 9000 plumages with the preparation of 1.5% comparative example 2, three hen houses.
Feeding manner：Half four layers of staged cage, semi-automatic hen house.
Application method：The wall for place and light below the 2m preferably away from ground that all flies inside and outside to hen house easily fall
Table (can not spray) with chicken, be diluted according to the consumption of various products and according to making.
Test data sheet index：The daily main production target that test chicken group is collected by laboratory technician：Egg production is (good egg number, broken
Egg number), egg size, death eliminate number；The quantity of fly inside and outside hen house, the clinical application effect statistics of medicine is shown in Table 4,5.
The egg laying performance statistical form of table 47, three hen houses of August
| Hen house number | Laying rate/% | Death and culling rate/% | Every piece of egg size/g |
| A | 91.66 | 0.55 | 55.66 |
| B | 86.88 | 0.79 | 54.06 |
| C | 85.31 | 0.86 | 53.21 |
Fly quantity (after medication 5 days) statistical form of table 57, three hen houses of August
| Hen house number | A | B | C |
| Fly quantity | 9.21 | 15.12 | 18.03 |
From the test data of table 4 and table 5,5.0% decis and 1.5% bromine cyanogen insect amide oil emu of the invention
In hen house after use, egg laying performance will be due to it at laying rate, death and culling rate, three aspects of every piece of egg size in two months hen houses
His two kinds of similar competing products, meanwhile, count in two months, the 5 days fly quantity in hen house, of the invention after medication
5.0% decis and 1.5% bromine cyanogen insect amide oil emu can effectively kill fly after use, accomplish the effect of environmental Kuznets Curves
Really.In summary, this test statistics result has absolutely proved 5.0% decis of the invention and the 1.5% bromine cyanogen worm of the present invention
Acid amides oil emu killing fly is good, can reach good Environmental Control Effect.
Experimental example 2
Compound decis preparation obtained by Example 2, embodiment 3 and embodiment 4, and according to experimental example 1 respectively
Described in method, to obtained by above three embodiment compound decis preparation carry out stability test, as a result show
0th, 5, under 10 days temperature, three environmental factors of illumination and humidity, compound decis preparation prepared by three embodiments it is outer
See character, relative density (0.960~0.980), emulsibility and content (accounting for labelled amount=90%~110%) and meet quality mark
It is accurate.
Then, the compound decis preparation using embodiment 2,3,4 is test medicine, and according to the methods described of experimental example 1
Clinical drug trial is carried out, wherein：D hen house applies the compound decis preparation of embodiment 2；E hen house, which is applied, to be implemented
The compound decis preparation of example 3；F hen house applies the compound decis preparation of embodiment 4；Clinical statisticses result is seen below
Table 6, table 7
The egg laying performance statistical form of table 67, three hen houses of August
| Hen house number | Laying rate/% | Death and culling rate/% | Every piece of egg size/g |
| D | 89.27 | 0.67 | 54.68 |
| E | 88.76 | 0.62 | 54.79 |
| F | 90.13 | 0.63 | 55.06 |
Fly quantity (after medication 5 days) statistical form of table 77, three hen houses of August
| Hen house number | D | E | F |
| Fly quantity | 11.53 | 12.65 | 10.89 |
From table 6, the test data of table 7, equally had as the compound decis preparation prepared by the method for embodiment 2,3,4
There is good stability, while also can effectively kill fly, and play preferable Environmental Control Effect.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
Many other changes and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of compound decis preparation, it is characterised in that according to percent by weight, the compound decis preparation master
To be made up of following components：
Decis 1.0~30.0%, emulsifying agent 1.0~30.0%, synergist 1.0~30.0%, stabilizer 1.0~
10.0%, and biodiesel 10.0~90.0%.
2. compound decis preparation according to claim 1, it is characterised in that according to percent by weight, described multiple
Square decis preparation is mainly made up of following components：
Decis 5.0~20.0%, bromine cyanogen insect amide 1.0~5.0%, emulsifying agent 4.0~30.0%, synergist 5.0~
20.0%, stabilizer 3.0~7.0%, and biodiesel 20.0~80.0%.
3. compound decis preparation according to claim 1 or 2, it is characterised in that the emulsifying agent be polysorbate-
80th, Crodaret, nonyl phenol polyethenoxy ether, and one kind in APES or any two
The blended emulsifier planted；
It is preferred that, the emulsifying agent is the blended emulsifier of Tween-80 and Crodaret.
4. compound decis preparation according to claim 1 or 2, it is characterised in that the synergist is piperonyl fourth
One kind or any two kinds of synergistic blend agent in ether, Octachlorodipropyl Ether, or Octacide 264；
It is preferred that, the synergist is the synergistic blend agent of piperonyl butoxide and Octachlorodipropyl Ether.
5. compound decis preparation according to claim 1 or 2, it is characterised in that the stabilizer is dimethyl methyl
One or more mixed stabilizers in acid amides, ethylene glycol, isopropanol, or phenmethylol；
It is preferred that, the stabilizer is phenmethylol.
6. compound decis preparation according to claim 1 or 2, it is characterised in that decis and bromine cyanogen insect amide
Mass ratio be (3~5)：1；
It is preferred that, the mass ratio of decis and emulsifying agent is 1：(2~3)；
It is preferred that, the mass ratio of decis and synergist is (1~2)：(1~2).
7. the preparation method of compound decis preparation any one of claim 1-6, it is characterised in that methods described bag
Include following steps：
Decis and bromine cyanogen insect amide are added in emulsifying agent and synergist, and heating stirring dissolves；Then biological bavin is added
Oil and stabilizer, heating stirring mixing, cooling filtering produce the compound decis preparation.
8. preparation method according to claim 7, it is characterised in that methods described, which is additionally included in, adds the same of decis
When the step of be additionally added bromine cyanogen insect amide.
9. application of the compound decis preparation any one of claim 1-6 in fly, fly blow and larva is killed.
10. include the muscicide of compound decis preparation any one of claim 1-6.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710200930.5A CN106942266A (en) | 2017-03-29 | 2017-03-29 | Compound decis preparation and its preparation method and application and the muscicide comprising it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710200930.5A CN106942266A (en) | 2017-03-29 | 2017-03-29 | Compound decis preparation and its preparation method and application and the muscicide comprising it |
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| Application Number | Title | Priority Date | Filing Date |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111053805A (en) * | 2019-12-27 | 2020-04-24 | 内蒙古农业大学 | External emulsion for camel vaginal myiasis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194606A (en) * | 2006-12-04 | 2008-06-11 | 湖南万家丰科技有限公司 | Pesticide missible oil preparation containing biological diesel oil solvent |
| CN102283205A (en) * | 2004-07-26 | 2011-12-21 | 杜邦公司 | Mixtures of anthranilamide invertebrate pest control agents |
-
2017
- 2017-03-29 CN CN201710200930.5A patent/CN106942266A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283205A (en) * | 2004-07-26 | 2011-12-21 | 杜邦公司 | Mixtures of anthranilamide invertebrate pest control agents |
| CN101194606A (en) * | 2006-12-04 | 2008-06-11 | 湖南万家丰科技有限公司 | Pesticide missible oil preparation containing biological diesel oil solvent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111053805A (en) * | 2019-12-27 | 2020-04-24 | 内蒙古农业大学 | External emulsion for camel vaginal myiasis and preparation method thereof |
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