CN106937894A - Strengthen development mark, intravascular stent and the method for intravascular stent developing performance - Google Patents

Strengthen development mark, intravascular stent and the method for intravascular stent developing performance Download PDF

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Publication number
CN106937894A
CN106937894A CN201710158213.0A CN201710158213A CN106937894A CN 106937894 A CN106937894 A CN 106937894A CN 201710158213 A CN201710158213 A CN 201710158213A CN 106937894 A CN106937894 A CN 106937894A
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CN
China
Prior art keywords
intravascular stent
development
mark
developing
bonded
Prior art date
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Pending
Application number
CN201710158213.0A
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Chinese (zh)
Inventor
王黎洲
许敏
黄学卿
安天志
李兴
蒋天鹏
宋杰
周石
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Affiliated Hospital of Guizhou Medical University
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Affiliated Hospital of Guizhou Medical University
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Priority to CN201710158213.0A priority Critical patent/CN106937894A/en
Publication of CN106937894A publication Critical patent/CN106937894A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

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  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Strengthen development mark, intravascular stent and the method for intravascular stent developing performance.The invention discloses the development mark of intravascular stent, indicate two to six vertical at least one developing rings for developing mark and being connected to each end of intravascular stent for including being bonded along intravascular stent length direction including development mark is bonded on intravascular stent using medical polymer adhesive, and developed;Each developing ring and vertical development mark are be bonded by medical polymer adhesive;So that some developing rings are formed along the cylindrical developer on the outside of intravascular stent with some vertical development marks marks profile.Intravascular stent, including the rack body being made up of developing material, and it is bonded in the above-mentioned development mark on the outside of rack body.Strengthen the method for intravascular stent developing performance, be marked using above-mentioned intravascular stent to inserting lesion locations.The invention provides the development mark for showing intravascular stent integrity profile on the whole, and the intravascular stent indicated using the development, indicated using above-mentioned development and intravascular stent, be preferable developing method.

Description

Strengthen development mark, intravascular stent and the method for intravascular stent developing performance
Technical field
The present invention relates to stent technology field, more particularly to strengthen intravascular stent developing performance development mark, Intravascular stent and method.
Background technology
Cardiovascular stents refer on the basis of tube chamber balloon expandable is molded, and are implanted into lesion locations, to reach Stenosis occlusion section blood vessel is supported, blood vessel elasticity retraction and again plasticity is reduced, keeps the support knot of the unobstructed purpose of tube chamber blood flow Structure.
The annual cardiovascular embolism intervention support operation of China in 2013 reaches 600,000, and remains annual more than 35% Growth rate.However, 6-8 months after intervention support treatment, patient's implantation support portions are likely to occur cardiovascular restenosis, Situation about even blocking again.At present except thermal imaging, echocardiogram, visualization, the complicated and expensive method such as CT does not have Very good solution.In recent years, it is thus proposed that install sensor can be utilized in angiocarpy to realize detection.But, The solution that this kind equipment is not molded also, especially needs to set special day for micromodule equipment, sensor etc. in the blood vessels Line and power supply unit.
Developing performance of the intravascular stent under X-ray production apparatus or other medical imaging devices is one in the numerous performances of support Item key property, it all plays vital effect to clinical effectiveness in surgical procedure and Post operation.In surgical procedure, Doctor needs to position exactly by the developing performance of intravascular stent and discharge support, to ensure that support can be implanted into exactly To lesion locations., it is necessary to ensure that support will not be shifted and cause new by follow-up during being chronically implanted after surgery Thrombus.
Current intravascular stent generally uses 316L stainless steels, cochrome, Nitinol, magnesium alloy or macromolecule material Material etc. is processed.For intracranial vessel support, due to the special physiological anatomical structure (presence of such as skull) of intracranial vessel, Intracranial vessel support is have impact on preferably to develop.In addition, the flexibility of intracranial vessel support is it is required that intracranial vessel support The metal coverage rate of metallic framework is fewer than coronary vessel stent, and this is cause intracranial vessel support developing performance poor another One factor., can only be by increasing the chi of supporting structure if relying on the material of support in itself to increase developing performance merely The very little purpose to reach enhancing developing performance, but it means that more metal implantation.For Point of View of Clinical, this can increase The risk of biocompatibility, increases thrombotic probability, simultaneously because the increase of metal causes support to be hardened, therefore it is unfavorable In the blood vessel for making support pass through complicated and minor diameter.
A kind of mode of enhancing developing performance of prior art be by increase the developing performance of mount proximal end and distal end come Improve support developing performance, this be usually by using certain technique will develop pipe or developing material be fixed on support Two ends are realized.But, this design has the disadvantages that:First, two end points of distance of support are only able to display, and can not Show integral support, and also can result in if technique is unstable development pipe or developing material comes off;In addition, this The external diameter of the end of the support of design can be unfavorable for the assembling of support, and the softness of influence support than larger in technique Property.
Chinese Patent Application No. is CN201110234883.9, entitled to strengthen the developability of intravascular stent for a kind of The method and a kind of intravascular stent of improvement developing performance, particularly intracranial vessel support of energy.According to the present invention, in the branch of support At least one layer of silk material being made up of developing material is integrally wound on frame ripple bar.On the one hand the support of the present invention ensure that in art Be accurately positioned with postoperative under medical imaging device, on the other hand winding development silk material be located at support on not by stress or by should The position of power very little, expansion and stress distribution without influenceing support, so that the life-span of support will not be reduced, is not interfered with yet The expection using effect of support.
But the intravascular stent of this kind of structure fabrication is used, its existing silk material is integrally wrapped in intravascular stent outer wall, to blood Pipe holder can cause certain pressure, and the support of silk material winding, although can show the shadow of intravascular stent comprehensively, still The concrete condition of support can not be observed so that intravascular stent is difficult to control.And the intravascular stent of silk material winding, when it develops Bunch up, it is difficult to grasp the profile of intravascular stent, so be not very accurate to observation intravascular stent.
The content of the invention
In order to overcome the above-mentioned deficiencies of the prior art, intravascular stent can be shown on the whole the invention provides one kind The development mark of integrity profile, while being formed between developing ring and development mark by the way that medical polymer adhesive is Nian Jie, ring Ensure safety.Present invention also offers a kind of intravascular stent indicated using the development, the intravascular stent also uses developing material system Into can show the details of intravascular stent when in use, more facilitate doctor to observe complete intravascular stent support situation, be easy to In art and postoperative operative treatment and rehabilitation to patient.Upper two kinds of structures can strengthen the development of intravascular stent, make It is preferable developing method with above-mentioned development mark and intravascular stent.
The technical solution adopted in the present invention is:The development mark of intravascular stent, including using medical polymer bonding Development mark is bonded on intravascular stent by agent, and the mark that develops includes two to six along intravascular stent length direction bonding Vertical development mark and at least one developing ring for being connected to each end of intravascular stent;
Each developing ring and vertical development mark are be bonded by medical polymer adhesive;
Finally so that some developing rings are taken turns with some vertical development mark formation along the cylindrical developer mark on the outside of intravascular stent It is wide.
Further, each vertical development is masked as rectangle development bar structure, and it is bonded in intravascular stent end Between developing ring.
Further, developing ring is semi-open-type structure, and it is provided with one in the junction with each vertical development mark A vertical development is bonded with individual connection breach, each connection breach by medical polymer adhesive to indicate;And show Shadow ring is agreed to be bonded on the outer wall of intravascular stent by medical polymer adhesive.
Further, each developing ring is made up of cylindrical type development screw mandrel, 0.2~0.5mm of diameter of its developing ring, its A diameter of 0.05~0.12mm of cylindrical type development screw mandrel.
Further, medical polymer adhesive is degradable high polymer material, by PLA, PLLA, is gathered One or more in racemic lactic acid, PCL, PTMC are made.
Intravascular stent, including the rack body being made up of developing material, and be bonded in above-mentioned aobvious on the outside of rack body Shadow mark.
Strengthen the method for intravascular stent developing performance, be marked using above-mentioned intravascular stent to inserting lesion locations.
Compared with prior art, the beneficial effects of the invention are as follows:The intravascular stent of the present invention develops mark respectively along blood vessel The two ends of support set at least one developing ring, and are connected between the developing ring at two ends two and develop vertically to the six roots of sensation mark Will, so that intravascular stent whole show be come out, when in use, can intactly show the overall profile of intravascular stent, simultaneously Because development mark is unobstructed to intravascular stent, it is observed that the comprehensive situation of intravascular stent.
Brief description of the drawings
The structure chart that Fig. 1 indicates for the development of intravascular stent;
The intravascular stent structure chart that Fig. 2 indicates for the development of the embodiment with Fig. 1;
Wherein:1- intravascular stents, 2- development marks, 3- develops mark, 4- developing rings, 41- connection breach vertically;5- cylinders are aobvious Shadow marks profile.
Embodiment
In order to deepen the understanding of the present invention, the present invention is further described with reference to the accompanying drawings and examples, the implementation Example is only used for explaining the present invention, and protection scope of the present invention is not constituted and limited.
As shown in figure 1, the development mark of intravascular stent, including glued development mark 2 using medical polymer adhesive It is connected on intravascular stent 1, and the mark 2 that develops includes indicating along two to six vertical developments that intravascular stent length direction is bonded 3 and it is connected at least one developing ring 4 of each end of intravascular stent;
Each developing ring 4 and vertical development mark 3 are be bonded by medical polymer adhesive;
Finally so that some developing rings 4 are formed along the cylindrical developer mark on the outside of intravascular stent with some vertical development marks 3 Profile 5.
In the above-described embodiments, each mark 3 that develops vertically is rectangle development bar structure, and it is bonded in intravascular stent Between the developing ring 4 of end.
In the above-described embodiments, developing ring 4 is semi-open-type structure, and it is in the connection with each vertical development mark 3 Place is provided with a connection breach 41, and each connection breach 41 are interior to be bonded with a vertical development by medical polymer adhesive Mark 3;And developing ring 4 is agreed to be bonded in by medical polymer adhesive on the outer wall of intravascular stent 1.
In the above-described embodiments, each developing ring 4 is made up of cylindrical type development screw mandrel, and the diameter 0.2 of its developing ring 4~ 0.5mm, a diameter of 0.05~0.12mm of its cylindrical type development screw mandrel.
In the above-described embodiments, medical polymer adhesive is degradable high polymer material, by PLA, gathers left-handed breast One or more in sour, poly- racemic lactic acid, PCL, PTMC are made.
As shown in Fig. 2 intravascular stent, including the rack body being made up of developing material, and be bonded in outside rack body The above-mentioned development mark of side.
Strengthen the method for intravascular stent developing performance, above-mentioned intravascular stent is marked to inserting lesion locations.
What embodiments of the invention were announced is preferred embodiment, but is not limited thereto, the ordinary skill people of this area Member, easily according to above-described embodiment, understands the spirit of the present invention, and makes different amplifications and change, but as long as not departing from this The spirit of invention, all within the scope of the present invention.

Claims (7)

1. the development mark of intravascular stent, it is characterised in that indicate including will be developed using medical polymer adhesive(2)It is viscous It is connected on intravascular stent(1)On, and the mark that develops(2)Two to six vertical developments including being bonded along intravascular stent length direction Mark(3)With at least one developing ring for being connected to each end of intravascular stent(4);
Each described developing ring(4)Indicate with vertical development(3)It is bonded by medical polymer adhesive;
Finally so that some developing rings(4)Indicate with some vertical developments(3)Formed along the cylindrical developer on the outside of intravascular stent Mark profile(5).
2. the development mark of intravascular stent according to claim 1, it is characterised in that each described vertical development mark Will(3)For rectangle development bar structure, it is bonded in the developing ring of intravascular stent end(4)Between.
3. the development mark of intravascular stent according to claim 1 or 2, it is characterised in that developing ring(4)For semi-open-type Structure, it indicates with each vertical development(3)Junction provided with connection breach(41), each connection breach (41)It is interior that a vertical development mark is bonded with by medical polymer adhesive(3);And the developing ring(4)Agree to logical Cross medical polymer adhesive and be bonded in intravascular stent(1)Outer wall on.
4. the development mark of intravascular stent according to claim 3, it is characterised in that each described developing ring(4)For Cylindrical type development screw mandrel is made, its developing ring(4)0.2~0.5mm of diameter, its cylindrical type development screw mandrel a diameter of 0.05~ 0.12mm。
5. the development mark of intravascular stent according to claim 3, it is characterised in that medical polymer adhesive is can Degraded macromolecular material, by PLA, PLLA, poly- racemic lactic acid, PCL, PTMC In one or more be made.
6. intravascular stent, it is characterised in that:Including the rack body being made up of developing material, and it is bonded on the outside of rack body As the development mark described in claim 1-5 any one.
7. strengthen the method for intravascular stent developing performance, it is characterised in that the intravascular stent described in usage right requirement 6 is to inserting Lesion locations are marked.
CN201710158213.0A 2017-03-16 2017-03-16 Strengthen development mark, intravascular stent and the method for intravascular stent developing performance Pending CN106937894A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110420075A (en) * 2019-06-27 2019-11-08 深圳市先健畅通医疗有限公司 Overlay film frame

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047050A (en) * 1987-02-17 1991-09-10 Alberto Arpesani Internal prosthesis with radiopaque annular portions
WO1999002195A2 (en) * 1997-07-07 1999-01-21 Implant Sciences Corporation Coronary stent with a radioactive, radiopaque coating
CN1248156A (en) * 1997-01-21 2000-03-22 斯滕特技术公司 Multilayer composite tubular structure and method of making
US20030121148A1 (en) * 2000-10-26 2003-07-03 Scimed Life Systems, Inc. Stent having radiopaque markers and method of fabricating the same
CN200998331Y (en) * 2006-11-16 2008-01-02 沈阳 Radiation supporting stand positioned in human body that can developing clearly under X ray
US20100152837A1 (en) * 2008-01-07 2010-06-17 Micrus Endovascular Corporation Radiopaque super-elastic intravascular stent
CN102429750A (en) * 2011-08-15 2012-05-02 微创医疗器械(上海)有限公司 Intravascular stent with improved developing performance and method for improving developing performance of intravascular stent
CN102440856A (en) * 2011-12-09 2012-05-09 微创医疗器械(上海)有限公司 Biodegradable stent capable of being seen under X rays and preparation method of biodegradable stent
CN202802476U (en) * 2012-06-19 2013-03-20 东莞市博迪思迈医疗器械有限公司 X-ray development mark ring
CN105457105A (en) * 2015-07-24 2016-04-06 中国科学院金属研究所 Novel developable magnesium alloy intravascular stent

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047050A (en) * 1987-02-17 1991-09-10 Alberto Arpesani Internal prosthesis with radiopaque annular portions
CN1248156A (en) * 1997-01-21 2000-03-22 斯滕特技术公司 Multilayer composite tubular structure and method of making
WO1999002195A2 (en) * 1997-07-07 1999-01-21 Implant Sciences Corporation Coronary stent with a radioactive, radiopaque coating
US20030121148A1 (en) * 2000-10-26 2003-07-03 Scimed Life Systems, Inc. Stent having radiopaque markers and method of fabricating the same
CN200998331Y (en) * 2006-11-16 2008-01-02 沈阳 Radiation supporting stand positioned in human body that can developing clearly under X ray
US20100152837A1 (en) * 2008-01-07 2010-06-17 Micrus Endovascular Corporation Radiopaque super-elastic intravascular stent
CN102429750A (en) * 2011-08-15 2012-05-02 微创医疗器械(上海)有限公司 Intravascular stent with improved developing performance and method for improving developing performance of intravascular stent
CN102440856A (en) * 2011-12-09 2012-05-09 微创医疗器械(上海)有限公司 Biodegradable stent capable of being seen under X rays and preparation method of biodegradable stent
CN202802476U (en) * 2012-06-19 2013-03-20 东莞市博迪思迈医疗器械有限公司 X-ray development mark ring
CN105457105A (en) * 2015-07-24 2016-04-06 中国科学院金属研究所 Novel developable magnesium alloy intravascular stent

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110420075A (en) * 2019-06-27 2019-11-08 深圳市先健畅通医疗有限公司 Overlay film frame
CN110420075B (en) * 2019-06-27 2022-04-05 深圳市先健畅通医疗有限公司 Covered stent

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