CN106914289B - Producing device of micro-fluidic chip and preparation method thereof - Google Patents
Producing device of micro-fluidic chip and preparation method thereof Download PDFInfo
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- CN106914289B CN106914289B CN201710301713.5A CN201710301713A CN106914289B CN 106914289 B CN106914289 B CN 106914289B CN 201710301713 A CN201710301713 A CN 201710301713A CN 106914289 B CN106914289 B CN 106914289B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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Abstract
The present invention relates to producing devices of a kind of micro-fluidic chip and preparation method thereof.The producing device of the micro-fluidic chip includes micro-fluidic chip molding die, box body, box cover, punch and support chip, which is equipped with the molding hole being connected to default runner；The box body has forming cavity, and the bottom of the box body is for micro-fluidic chip molding die described in fixed placement；The box cover can be fastened and connected with box body, which is equipped with lid mouth；The punch is adapted with molding hole, which can be inserted into molding hole by lid mouth；The support chip is removably set on the box cover, is used to support the punch being inserted in molding hole.The hole roughness of the producing device production of the micro-fluidic chip is low, duct trans D consistent degree is high, and dregs are few in process, and small, the accuracy and precision height of sample analysis is influenced on the variation of chip channel fluid parameter.
Description
Technical field
The present invention relates to micro-fluidic chip fields, producing device and its production side more particularly to a kind of micro-fluidic chip
Method.
Background technique
Micro-fluidic chip is the basic operation units such as sample preparation, reaction, separation, detection to be integrated into one piece of micro-meter scale
Chip on, be automatically performed analysis overall process, have been widely used in the research fields such as biology, chemistry, medicine.Micro-fluidic chip adds
Work method mainly uses pressure sintering, injection moulding or horizontal mold method.The material of chip mainly uses silicon materials, hyaline-quartz or organic
Polymer, wherein the dimethyl silicone polymer in organic polymer (PDMS) because have good translucidus, bio-compatibility, easily
The advantages such as processing and cost of manufacture are low are widely used.
It is by perforating needle manual punching hole processing and fabricating sample feeding in micro-fluidic chip process, in traditional technology
The holes such as hole, sample sample outlet hole, waste liquid sample holes and waste liquid fluid hole.But due to the material of perforating needle smoothness and PDMS spy
Property, the hole edge edge roughness of processing and fabricating is high, and the trans D in duct is inconsistent, will cause the absorption of sample in use or lets out
Leakage.In addition, the dregs generated in perforating needle drill process will cause the variation of chip channel fluid parameter, or even chip can be blocked,
And then it will affect the accuracy and precision of sample analysis.
Summary of the invention
Based on this, it is necessary to provide that a kind of roughness is low, trans D consistent degree of duct is high and process in dregs
Few producing device of micro-fluidic chip and preparation method thereof.
A kind of producing device of micro-fluidic chip includes:
Micro-fluidic chip molding die, the micro-fluidic chip molding die surface are equipped with the molding being connected to default runner
Hole；
Box body, the box body have forming cavity, and the bottom of the box body is for the molding of micro-fluidic chip described in fixed placement
Mold；
Box cover, the box cover can be fastened and connected with the box body, and the box cover is equipped with lid mouth；
Punch, the punch are adapted with the molding hole, and the punch can be inserted by the lid mouth
In the molding hole；And
Support chip, the support chip are removably set on the box cover, are used to support and are inserted in the molding hole
The punch.
The producing device of the micro-fluidic chip includes micro-fluidic chip molding die, box body, box cover, punch and support
Piece, the micro-fluidic chip molding die fixed placement is in the bottom of the box body, the punch and the micro-fluidic chip
Molding hole in molding die is adapted, and the punch can be inserted into the molding hole by the lid mouth.By micro-
Fluidic chip molding die, box body, box cover, punch and support chip are worked in coordination, the producing device energy of the micro-fluidic chip
It is enough that sample feeding hole, sample sample outlet hole, waste liquid sample holes and waste liquid fluid hole are done directly in micro-fluidic chip forming process
The production in the hole Deng needed for, relative to traditional manual punching hole, the hole roughness of production is low, duct trans D consistent degree
Height, and dregs are few in process, changing on chip channel fluid parameter influences small, the accuracy and precision of sample analysis
It is high.In addition, the producing device structure of the micro-fluidic chip is simple, convenient for the industrialization production of micro-fluidic chip.
The diameter of the box body is 1cm-1m in one of the embodiments, and the material of the box body is polypropylene and gathers
The one or two of styrene.By the way that the diameter of box body is set as 1cm-1m, it can be used to the micro- of fixed larger size range
Fluidic chip molding die.Box body is convenient for observation box body using one or two kinds of transparent materials of polypropylene and polystyrene
In forming process, be also easy to the processing of box body.
It is additionally provided between the bottom of the box body and the micro-fluidic chip molding die in one of the embodiments, viscous
Layer is tied, the adhesive layer is for fixing the micro-fluidic chip molding die.
The material of the adhesive layer is dimethyl silicone polymer in one of the embodiments,.Dimethyl silicone polymer is
Transparent binding material is convenient for the intracorporal forming process of observation box.
The side wall of the box body is equipped with altitude scale line in one of the embodiments,.It, can by being equipped with altitude scale line
Preferably to adjust the additional amount of performed polymer, and then the thickness of casting micro-fluidic chip can be accurately controlled.
The diameter of the box cover is 1cm-1m in one of the embodiments, and the material of the box cover is polypropylene and gathers
The one or two of styrene.
The box cover, which is connected through a screw thread, in one of the embodiments, is fastened on the box body.It is connected through a screw thread, just
It is installed in the assembly of box body and box cover.
It in one of the embodiments, further include three-dimensional trim holder, the three-dimensional trim holder connects the punch, is used for
Finely tune the position that the punch is inserted into the molding hole.It, being capable of comprehensive fine tuning punching by being equipped with three-dimensional trim holder
Device guarantees that punch is accurately inserted into molding hole, guarantees the production precision in hole.
The diameter of the punch is 1 μm of -100mm in one of the embodiments,.
In addition, there is a need to provide a kind of production method of micro-fluidic chip.
A kind of production method of micro-fluidic chip, uses the producing device system of micro-fluidic chip described in any of the above-described embodiment
Make, production method specifically comprises the following steps:
By the micro-fluidic chip molding die fixed placement in the bottom of the box body；
The box cover and the box body are fastened and connected；
The punch is inserted into the molding hole of the micro-fluidic chip molding die by the lid mouth；
The support chip is set on the box cover and is supported and secures the above punch；
Performed polymer is added in the forming cavity of the box body by the lid mouth；
The box body that performed polymer is added is subjected to heating, drying processing, is cooled to room temperature after heating；
After the support chip is dismantled from the box cover, the punch is extracted vertically, completes micro-fluidic chip mesoporous
Production.
The hole roughness of the micro-fluidic chip of the production method production of the micro-fluidic chip is low, duct trans D is consistent
Degree is high, and dregs are few in process, and changing on chip channel fluid parameter influences small, the accuracy and precision of sample analysis
It is high.In addition, the production method of the micro-fluidic chip is simple to operation, it is convenient for industrialization production.
Detailed description of the invention
Fig. 1 is the box body structure schematic diagram of the producing device of the micro-fluidic chip of an embodiment；
Fig. 2 is the box cover structural schematic diagram in the producing device of micro-fluidic chip shown in FIG. 1.
The reference numerals are as follows:
10. the producing device of micro-fluidic chip, 100. micro-fluidic chip molding dies, 101. molding holes, 110. box bodys,
120. box cover, 121. lid mouths, 130. punch, 140. support chips.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give presently preferred embodiments of the present invention.But the invention can be realized in many different forms, however it is not limited to this paper institute
The embodiment of description.On the contrary, purpose of providing these embodiments is keeps the understanding to the disclosure more thorough
Comprehensively.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
The producing device 10 of the micro-fluidic chip includes micro-fluidic chip shaping mould in embodiment as depicted in figs. 1 and 2
Tool 100, box body 110, box cover 120, punch 130 and support chip 140.
100 surface of micro-fluidic chip molding die is equipped with the molding hole 101 being connected to default runner.Optionally, this is micro-
Fluidic chip molding die 100 can be equipped with multiple molding holes 101.The molding hole 101 is processed in micro-fluidic chip
Sample feeding hole, sample sample outlet hole, waste liquid sample hole and waste liquid fluid hole etc. it is all kinds of needed for holes.
The box body 110 has forming cavity, and the bottom of the box body 110 is used for the fixed placement micro-fluidic chip molding die
100.The size of box body 110 is adapted with the size of micro-fluidic chip molding die 100, and optionally, the size of box body 110 is greater than
The size of micro-fluidic chip molding die 100.
In one embodiment, the diameter of the box body 110 is 1cm-1m, and the material of the box body 110 is polypropylene and polyphenyl
The one or two of the transparent materials such as ethylene.By the way that the diameter of box body 110 is set as 1cm-1m, box body 110 can be made to be suitable for
The micro-fluidic chip molding die 100 of fixed larger range size.Box body 110 using polypropylene and polystyrene etc. transparent materials
That expects is one or more, convenient for the forming process in observation box body 110, is also easy to the processing of box body 110.
In one embodiment, bonding is additionally provided between the bottom of the box body 110 and the micro-fluidic chip molding die 100
Layer (not shown), the adhesive layer is for fixing the micro-fluidic chip molding die 100, it is ensured that the formed precision of micro-fluidic chip.
In one embodiment, the adhesive layer is using transparent materials such as dimethyl silicone polymer, polypropylene and polystyrene
One of or it is a variety of.By being coated with the transparent materials such as dimethyl silicone polymer, polypropylene or polystyrene in 110 bottom of box body
Material, for the micro-fluidic chip molding die 100 in fixed bin body 110.
In one embodiment, the side wall of the box body 110 is equipped with altitude scale line (not shown).By being equipped with altitude scale
Line, can preferably adjust the additional amount of performed polymer, and then can accurately control the thickness of casting micro-fluidic chip.The height
The range of graduation mark can specifically be adjusted according to the height of box body 110.
The box cover 120 can be fastened and connected with the box body 110.The size of the box cover 120 and the size of box body 110 are mutually fitted
Match, it is ensured that box cover 120 will not move after being fastened and connected with the box body 110.Box cover 120 matches connection buckle together in box body by size
110.Optionally, which, which is connected through a screw thread, is fastened on the box body 110.It is connected through a screw thread, is convenient for box body 110 and box
The assembly of lid 120 is installed.The box cover 120 is equipped with lid mouth 121.The punch 130 can move in lid mouth 121, it is ensured that punching
Device 130 is accurately inserted into molding hole 101.Prepolymer liquid is also by lid mouth 121 for micro-fluidic chip shaping mould of casting
Tool 100.Position and prepolymer of the specific size of the lid mouth 121 according to the molding hole 101 in micro-fluidic chip molding die 100
The casting amount of liquid is adjusted, and guarantees the movement of punch 130, convenient for casting performed polymer liquid.
In one embodiment, the diameter of the box cover 120 is 1cm-1m, which uses polypropylene and polyphenyl second
The one or two of the transparent materials such as alkene.By the way that the diameter of box cover 120 is set as 1cm-1m, box cover 120 can be made to be suitable for pouring
Cast the micro-fluidic chip molding die 100 of larger range size.Box cover 120 using polypropylene and polystyrene equal transparent materials
It is one or more, convenient for control box body 110 in forming process, be also easy to the processing of box cover 120.
The punch 130 is adapted with the molding hole 101, the punch 130 can be inserted by the lid mouth 121 this at
In type hole 101.The punch 130 can be the metal materials such as steel, be also possible to hard material plastics, as long as can guarantee institute
Make the dimensional accuracy in hole.When molding hole 101 has multiple, punch 130 is also corresponding with multiple.Optionally, the punching
The diameter of device 130 is 1 μm of -100mm.Still optionally further, which is cylindrical structure.
The support chip 140 is removably set on the box cover 120, is used to support this dozen being inserted in the molding hole 101
Hole device 130.When punch 130 is inserted into molding hole 101, which is mounted on box cover, this dozen is used to support
Hole device 130；When punch needs are transferred to from molding hole 101, which is removed from box cover 120.The support chip
140 can use metal material, rigid plastics can also be used, as long as punch 130 can be supported.The support chip
140 can support the punch 130 by modes such as size matching or threaded connections.When punch 130 has multiple, support chip
140 be also correspondingly provided with it is multiple.
It in one embodiment, further include three-dimensional trim holder (not shown), which connects punch 130, uses
The position in the molding hole is inserted into finely tuning the punch 130.Optionally, which is detachably arranged in the box cover
On 120., being capable of comprehensive fine tuning punch 130 by being equipped with three-dimensional trim holder, it is ensured that punch 130 and micro-fluidic chip at
The molding hole 101 of pattern tool 100 is directed at fitting, guarantees the production precision in hole.
The producing device 10 of the micro-fluidic chip includes micro-fluidic chip molding die 100, box body 110, box cover 120, beats
Hole device 130 and support chip 140,100 fixed placement of micro-fluidic chip molding die is in the bottom of the box body 110, the punch
130 are adapted in the micro-fluidic chip molding die 100 molding hole 101, which can pass through the lid mouth 121
It is inserted into the molding hole 101.Pass through micro-fluidic chip molding die 100, box body 110, box cover 120, punch 130 and support
The producing device 10 of the mutual cooperation of piece 140, the micro-fluidic chip can be done directly sample in micro-fluidic chip forming process
The production in hole needed for product sample holes, sample sample outlet hole, waste liquid sample holes and waste liquid fluid hole etc. is beaten manually relative to traditional
Hole, the hole roughness of production is low, duct trans D consistent degree is high, and dregs are few in process, to chip channel stream
Body parametric variations are small, and the accuracy and precision of sample analysis is high.In addition, the knot of the producing device 10 of the micro-fluidic chip
Structure is simple, convenient for the industrialization production of micro-fluidic chip.
In addition, there is a need to provide a kind of production method of micro-fluidic chip.
A kind of production method of micro-fluidic chip is made using the producing device 10 of any of the above-described embodiment micro-fluidic chip
Make, production method specifically comprises the following steps:
By 100 fixed placement of micro-fluidic chip molding die in the bottom of the box body 110.Optionally, micro-fluidic chip
By being equipped with containing materials such as dimethyl silicone polymer, polypropylene or polystyrene between molding die 100 and the bottom of box body 110
Adhesive layer be adhesively fixed.
The box cover 120 and the box body 110 are fastened and connected, the size of the box cover 120 and the size of box body 110 match,
Guarantee to move after box cover 120 is fastened and connected with the box body 110.
The punch 130 is inserted into the molding hole 101 of the micro-fluidic chip molding die 100 by the lid mouth 121.
The punch 130 is adapted with the molding hole 101, and is adjusted punch 130 and be directed at fitting with molding hole 101.
The support chip 140 is installed on the box cover 120 and is supported and fixes the punch 130.Guarantee that pre-polymerization is being added
During body fluid body, the punch 130 having been fixed in molding hole 101 will not be moved.The support chip 140 can pass through size
The modes such as matching or threaded connection support the punch 130.
Performed polymer liquid is added in the forming cavity of the box body 110 by the lid mouth 121, for the micro-fluidic core of casting
Sheetmolding mold 100.Optionally, which is polymer poly dimethyl siloxane (PDMS).
The box body 110 that performed polymer liquid is added is subjected to heating, drying processing, is cooled to room temperature after heating.It is optional
Ground, the box body 110 are put into 65 DEG C of baking ovens and heat 4 hours.
After the support chip 140 is dismantled from the box cover 120, the punch 130, the hole on micro-fluidic chip are extracted vertically
Molding is completed.It will continue the subsequent processing operations of micro-fluidic chip, the production of micro-fluidic chip can be completed.
The micro-fluidic chip made by the production method of the micro-fluidic chip, hole roughness are low, duct laterally straight
Diameter consistent degree is high, and dregs are few in process, the variation of chip channel fluid parameter is influenced it is small, the accuracy of sample analysis and
Accuracy is high.In addition, the production method of the micro-fluidic chip is simple to operation, it is convenient for industrialization production.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (9)
1. a kind of producing device of micro-fluidic chip characterized by comprising
Micro-fluidic chip molding die, the micro-fluidic chip molding die surface are equipped with the molding hole being connected to default runner；
Box body, the box body have forming cavity, and the bottom of the box body is for micro-fluidic chip molding die described in fixed placement；
Box cover, the box cover, which is connected through a screw thread, is fastened on the box body, and the box cover is equipped with lid mouth；
Punch, the punch are adapted with the molding hole, and the punch can be inserted into described by the lid mouth
In molding hole；
Support chip, the support chip are detachably arranged on the box cover, be used to support be inserted in it is described in the molding hole
Punch；And
Three-dimensional trim holder, the three-dimensional trim holder connect the punch, are inserted into the molding for finely tuning the punch
Position in hole.
2. the producing device of micro-fluidic chip according to claim 1, which is characterized in that the diameter of the box body is 1cm-
1m, the material of the box body are one or both of polypropylene and polystyrene.
3. the producing device of micro-fluidic chip according to claim 1, which is characterized in that the bottom of the box body and described
Adhesive layer is additionally provided between micro-fluidic chip molding die, the adhesive layer is for fixing the micro-fluidic chip molding die.
4. the producing device of micro-fluidic chip according to claim 3, which is characterized in that the material of the adhesive layer is poly-
Dimethyl siloxane.
5. the producing device of micro-fluidic chip according to claim 1, which is characterized in that the side wall of the box body is equipped with height
Spend graduation mark.
6. the producing device of micro-fluidic chip according to claim 1, which is characterized in that the diameter of the box cover is 1cm-
1m, the material of the box cover are one or both of polypropylene and polystyrene.
7. the producing device of micro-fluidic chip according to claim 1, which is characterized in that the three-dimensional trim holder is removable
It is located at unloading on the box cover.
8. the producing device of micro-fluidic chip according to claim 1, which is characterized in that the diameter of the punch is 1 μ
m-100mm；
Alternatively, the molding hole is multiple, the punch and molding hole one-to-one correspondence；
Alternatively, the punch is made or is made of rigid plastics material using metal material.
9. a kind of production method of micro-fluidic chip, which is characterized in that use the micro-fluidic core as described in claim any one of 1-8
The producing device of piece makes, and production method specifically comprises the following steps:
By the micro-fluidic chip molding die fixed placement in the bottom of the box body；
The box cover is connected through a screw thread and is fastened with the box body；
The punch is inserted into the molding hole of the micro-fluidic chip molding die by the lid mouth, and using three-dimensional
The adjustment frame comprehensive fine tuning punch, so that the punch is directed at fitting with the molding hole；
The support chip is set on the box cover and is supported and secures the above punch；
Performed polymer is added in the forming cavity of the box body by the lid mouth；
The box body that performed polymer is added is subjected to heating, drying processing, is cooled to room temperature after heating；
After the support chip is dismantled from the box cover, the punch is extracted vertically, completes the system of micro-fluidic chip mesoporous
Make.
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| CN112387316B (en) * | 2019-08-19 | 2021-09-21 | 中国科学院亚热带农业生态研究所 | 3D micro-fluidic chip model, 3D micro-fluidic chip, and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530775A (en) * | 2009-03-03 | 2009-09-16 | 南京大学 | Micro-fluidic apparatus integrated with PDMS film, manufacturing method and application thereof |
| CN105268491A (en) * | 2015-10-26 | 2016-01-27 | 中国工程物理研究院激光聚变研究中心 | Method for preparing micro-fluidic/milli-fluidic chip by using detachable template |
| CN105665045A (en) * | 2016-02-05 | 2016-06-15 | 中国科学技术大学 | Micro-fluidic chip and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101356441B (en) * | 2005-10-25 | 2011-06-15 | 株式会社岛津制作所 | Flow through cell and manufacturing method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530775A (en) * | 2009-03-03 | 2009-09-16 | 南京大学 | Micro-fluidic apparatus integrated with PDMS film, manufacturing method and application thereof |
| CN105268491A (en) * | 2015-10-26 | 2016-01-27 | 中国工程物理研究院激光聚变研究中心 | Method for preparing micro-fluidic/milli-fluidic chip by using detachable template |
| CN105665045A (en) * | 2016-02-05 | 2016-06-15 | 中国科学技术大学 | Micro-fluidic chip and preparation method thereof |
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