CN106905320A - It is a kind of to be adapted to medicinal replace Buddhist nun and its preparation according to Shandong - Google Patents
It is a kind of to be adapted to medicinal replace Buddhist nun and its preparation according to Shandong Download PDFInfo
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- CN106905320A CN106905320A CN201510980745.3A CN201510980745A CN106905320A CN 106905320 A CN106905320 A CN 106905320A CN 201510980745 A CN201510980745 A CN 201510980745A CN 106905320 A CN106905320 A CN 106905320A
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- China
- Prior art keywords
- buddhist nun
- shandong
- mixed solvent
- acetone
- medicinal
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
The present invention provides and a kind of is adapted to medicinal replace Buddhist nun and its preparation according to Shandong.It is described low for Buddhist nun's impurity content according to Shandong, thus drug safety is higher.Of the invention to replace Buddhist nun's preparation process is simple according to Shandong, with low cost, optimization and exploitation to medicine have important value.
Description
Technical field
It is more particularly to a kind of to be adapted to medicinal replace Buddhist nun and its preparation according to Shandong the present invention relates to chemical medicine.
Background technology
B cell malignant tumour includes chronic lymphocytic leukemia (CLL), ALL (ALL), small pouring
Bar cell lymphoma (SLL), lymphoma mantle cell (MCL), follicular lymphoma (FL), Diffuse Large B-Cell Lymphoma
(DLBCL), Huppert's disease (MM) andMacroglobulinemia (WM).Traditional treatment includes benzenebutanoic acid nitrogen
The cell toxicity medicaments such as mustard, endoxan, fludarabine and bendamustine.Though these conventional medicaments can relief of symptoms, not
The survival of patients time can effectively be extended.And some patients are poor to chemotherapy side effect, it is bad that patients with recurrent there is also chemotherapeutics
Significant reaction increases and antitumor curative effect is reduced etc..
Molecular targeted therapy new drug is according to Shandong for Buddhist nun's (ibrutinib) (formula 1) for Bruton EGFR-TKs (BTK) suppress
Agent, its cancer cell that is accurately located at fast-growth different from cellulotoxic chemotherapeutics can avoid the injury to normal cell,
Reduce the toxic and side effects such as alopecia, gastrointestinal reaction and the bone marrow suppression of classic chemotherapy medicine.Controlled as MCL and CLL for Buddhist nun according to Shandong
Treat medicine and first obtain FDA (Food and Drug Adminstration) (FDA) approval after in November, 2013 and 2 months 2014.The FDA of in January, 2015
The application for expanding idicatio for Buddhist nun according to Shandong is have approved again, i.e., for treating WM.
There are various crystal formations for Buddhist nun's compound according to Shandong.Patent application CN104736178A discloses anhydrous for 3 kinds of Buddhist nun according to Shandong
Compound crystal formation (respectively crystal formation A, crystal formation B, crystal formation C) and 3 kinds of solvate crystal formations (respectively MIBK solvates crystal formation D, first
Solvate crystal formation E, Methanol solvate crystal formation F), wherein, use recrystallisation solvent methyl tertiary butyl ether(MTBE) (MTBE), diisopropyl
Ether (DIPE), ethyl acetate, isopropyl acetate, isopropanol, methyl iso-butyl ketone (MIBK) (MIBK), methyl ethyl ketone (MEK), acetone,
Methyl alcohol, nitromethane, 10% water propanone or 10% aqueous isopropanol replace Buddhist nun A to amorphous can acquisition for Buddhist nun's crystallization according to Shandong according to Shandong
Crystal formation.According to Shandong for Buddhist nun's A crystal formations X-ray powder diffraction (XRPD) figure 2- θ values be 5.7 ± 0.1 °, 13.6 ± 0.1 °, 16.1 ±
There is characteristic peak at 0.1 °, 18.9 ± 0.1 °, 21.3 ± 0.1 ° and 21.6 ± 0.1 °.
Found by the research to various recrystallisation solvents, methyl alcohol, water mixed solvent have more excellent Impurity removal effect, energy
Obtain high-purity replaces Buddhist nun's A crystal formations according to Shandong, and crystallized product HPLC purity is more than 99%.And methanol prices are cheap, it is suitable for work
Industry metaplasia is produced.But, obtain not good for Buddhist nun's sample appearance according to Shandong is crystallized with methyl alcohol, water mixed solvent, easily form larger hard
Block, moisture is difficult removal, and the undue drying temperature or extension time of improving can influence to replace the stability of Buddhist nun according to Shandong；And these are larger
Solubility property is poor after lump drying.
CN104327085A discloses a kind of height of the mixed crystallization solvent preparation of use isopropanol or acetone and normal heptane
Solubility replaces Buddhist nun's crystal formation according to Shandong, and compared with the crystal formation A of patent WO2013184572A1, the crystal formation solubility of CN104327085 exists
0.15mg/L is brought up to from 0.1mg/L in the simulated intestinal fluid of pH5.0, is brought up to from 0.36mg/L in the simulated gastric fluid of pH1.8
0.5mg/L.The new crystal form X ray powder diffraction pattern of CN104327085A 2- θ values be 5.2 ° ± 0.2 °, 17.6 ° ± 0.2 °,
22.1 ° ± 0.2 °, 19.3 ° ± 0.2 °, 22.4 ° ± 0.2 °, there is at 20.8 ° ± 0.2 ° characteristic peak, and CN104736178A A
Crystal formation characteristic peak is entirely different, and actually two kinds different to replace Buddhist nun's crystal formation according to Shandong.
The content of the invention
Found by numerous studies, crystallized with methyl alcohol, water mixed solvent for Buddhist nun according to Shandong and only produce a kind of crystal formation, and use third
Ketone, normal heptane mixed solvent crystallization can produce two kinds of different crystal forms.Inventor surprisingly, it is found that, optimization acetone, normal heptane
The crystallization processes parameter of mixed solvent, particularly described acetone, normal heptane mixed solvent and Yi Lu for Buddhist nun ratio for 5ml/g~
50ml/g, can obtain with CN104736178A have same characteristic features peak according to Shandong replace Buddhist nun's A crystal formations.Although A crystal formations of the present invention and
The crystal formation of CN104327085A is two kinds of different crystal formations, but A crystal formations outward appearance of the invention is good, and particle is uniform, soluble, molten
Solution property is significantly higher than the crystallized product of methyl alcohol, water mixed solvent.Also, acetone, normal heptane mixed solvent be not aqueous, crystallization is easily dried
It is dry.
The present invention provide it is a kind of be adapted to it is medicinal according to Shandong for Buddhist nun preparation method, its preparation method comprises the following steps：
(1) first crystallized with methyl alcohol, water mixed solvent；
(2) acetone, normal heptane mixed solvent crystallization, the acetone, normal heptane mixed solvent and Yi Lu is used to replace the ratio of Buddhist nun again
Example is 5ml/g~50ml/g；
(3) removal recrystallisation solvent is dried, is obtained and is adapted to medicinal replace Buddhist nun according to Shandong.
Methyl alcohol, water volume ratio are preferably 1 described in the step (1):1~10:1, more preferably 1:1~4:1；
Methyl alcohol, water mixed solvent and Yi Lu described in the step (1) are preferably 1ml/g~100ml/g for the ratio of Buddhist nun,
More preferably 5ml/g~50ml/g；
Acetone, normal heptane volume ratio are preferably 1 described in the step (2):1~1:10, more preferably 1:1~1:4；
The drying mode is preferably constant pressure and dry or drying under reduced pressure, is more preferably vacuum dried.
The vacuum drying temperature is preferably 10 DEG C~70 DEG C, more preferably 20 DEG C~60 DEG C, more preferably 25 DEG C~50 DEG C.
Enter on the one hand, the present invention provide it is a kind of be adapted to it is medicinal according to Shandong for Buddhist nun preparation method, its preparation method include it is as follows
Step：
(1) take according to Shandong for Buddhist nun's crude product, it is 1 to add volume ratio:1~4:1 methyl alcohol, water mixed solvent, filter after being sufficiently stirred for
Obtain solid, vacuum drying；
(2) to learn from else's experience and add volume ratio 1 for Buddhist nun according to Shandong after drying:1~1:4 acetone, normal heptane mixed solvent, are sufficiently stirred for
After be filtrated to get solid, the acetone, normal heptane mixed solvent and Yi Lu are 5ml/g~50ml/g for the ratio of Buddhist nun；
(3) vacuum drying removal recrystallisation solvent, obtains and is adapted to medicinal replace Buddhist nun according to Shandong.
Enter on the one hand, preparation method of the present invention according to Shandong for Buddhist nun comprises the following steps：
(1) take according to Shandong for Buddhist nun's crude product, it is 1 to add volume ratio:1~4:1 methyl alcohol, water mixed solvent, filter after being sufficiently stirred for
Obtain solid, 25 DEG C~50 DEG C vacuum dryings；
(2) to learn from else's experience and add volume ratio 1 for Buddhist nun according to Shandong after drying:1~1:4 acetone, normal heptane mixed solvent, are sufficiently stirred for
After be filtrated to get solid, the acetone, normal heptane mixed solvent and Yi Lu are 5ml/g~50ml/g for the ratio of Buddhist nun；
(3) 25 DEG C~50 DEG C vacuum drying removal recrystallisation solvents, obtain and are adapted to medicinal replace Buddhist nun according to Shandong.
Activated carbon decolorizing can be added in crystallization process, but it is inessential；Can also add crystal seed in crystallization process, but it is non-must
Will.
The present invention provide it is a kind of be adapted to it is medicinal according to Shandong for Buddhist nun preparation method, by increasing acetone and normal heptane mixed solvent
Crystallisation step, improves the deficiency of methyl alcohol, water mixed solvent crystallized product in terms of moisture and solubility, obtains with high-purity
With high-dissolvability Buddhist nun is replaced according to Shandong.The order of the two-step crystallization step is extremely important, and the present invention can not be obtained after putting the cart before the horse
It is adapted to medicinal replace Buddhist nun according to Shandong.
The present invention can be also removed effectively according to Shandong for the impurity in Buddhist nun.In single step acetone of the invention, normal heptane mixed solvent
Under 4 Crystallization, the A crystal formation HPLC purity for obtaining only has 95%.Using methyl alcohol, water mixed solvent can effectively remove according to
Moisture removal is effectively removed in Shandong then for water soluble salt and organic impurities in Buddhist nun's crude product using acetone and normal heptane mixed solvent,
Finally vacuum drying removal residual recrystallisation solvent.What the present invention was obtained can reach more than 99.5% according to Shandong for Buddhist nun's purity, and single miscellaneous
Less than 0.1%.
It is adapted to medicinal replace Buddhist nun according to Shandong the invention provides a kind of.With A crystal formations disclosed in prior art according to Shandong for Buddhist nun compared with,
It is of the invention low for Buddhist nun's impurity content according to Shandong, thus medicine stability is good, it is safe；And high-purity of the invention replaces Buddhist nun according to Shandong
Solubility is high, is conducive to improving drug effect, reduces drugloading rate.High-purity of the invention replaces Buddhist nun's preparation process is simple, low cost according to Shandong
Honest and clean, optimization and exploitation to medicine have important value.The preparation method is simple, effective, is adapted to large-scale industrial production,
With larger commercial application value.
On the other hand, Buddhist nun's preparation is replaced according to Shandong the invention provides one kind, the preparation is by the described high-purity of therapeutically effective amount
Du Yilu is mixed for Buddhist nun with one or more pharmaceutic adjuvant.
Brief description of the drawings
Fig. 1 schemes for the XRPD of inventive samples
Specific embodiment
The specific embodiment of form, makees further specifically to the above of the invention by the following examples
It is bright.But this scope for being interpreted as above-mentioned theme of the invention should not be only limitted to following examples.
Embodiment 1
According to Shandong for Buddhist nun as prepared by the method described in Chinese patent application CN101610676B.By 101g 4- amino -3-
(4- Phenoxyphenyls) -1H- pyrazolos [3,4-d] pyrimidine and 330g polymer connect triphenyl phasphine (TPP) (polymerlab) with
5L tetrahydrofurans (THF) are mixed.To sequentially adding 3- hydroxy piperidine -1- t-butyl formates (200g in gained mixture；
2.0 equivalents), diisopropyl azodiformate (99mL).The reactant mixture is stirred at room temperature overnight.The reaction is filtered to mix
Compound, then with purified by flash chromatography (pentane/ethyl acetate=1/1), is obtained with removing resin, and concentrated reaction mixture
Intermediate (55g).Above-mentioned intermediate (48.3g) is processed 1 hour with the 4N HCl/ dioxane solutions of 1L, is then concentrated to dryness.
Residue is dissolved in dichloromethane, adds triethylamine (42mL), is subsequently added into acryloyl chloride (10mL).Terminate this after 2 hours anti-
Should.The reactant mixture is washed with 5% (weight) aqueous citric acid solution, then uses salt water washing.Organic layer is dried simultaneously through MgSO4
Concentration, obtains according to Shandong for Buddhist nun's crude product, and HPLC purity is 90%.
Embodiment 2
Take and replace Buddhist nun crude product 20g according to Shandong according to prepared by embodiment 1,200ml methyl alcohol is dissolved under stirring, under being stirred after dissolving
100ml water is added dropwise over, 3h is kept stirring for after adding, be filtrated to get solid, 45 DEG C of vacuum dryings.What is dried replaces Buddhist nun's solid according to Shandong
Containing larger agglomerate thing, dissolubility is bad.
Embodiment 3
Take and add 100ml acetone and 100ml normal heptanes for Buddhist nun's crude product 10g according to Shandong according to prepared by embodiment 1, stir at room temperature
4h is mixed, solid is filtrated to get, 50 DEG C of vacuum drying 4h, obtain A crystal formations replaces Buddhist nun according to Shandong, described small and equal for Buddhist nun's particle according to Shandong
Even, dissolubility is good.
Embodiment 4
Take and replace Buddhist nun crude product 20g according to Shandong according to prepared by embodiment 1,200ml methyl alcohol is dissolved under stirring, under being stirred after dissolving
100ml water is added dropwise over, 3h is kept stirring for after adding, be filtrated to get solid, 45 DEG C of vacuum dryings.
Learn from else's experience and add 50ml acetone and 100ml normal heptanes for Buddhist nun 10g according to Shandong after drying, 4h is stirred at room temperature, filter
To solid, 30 DEG C of vacuum drying 4h, the high-purity for obtaining A crystal formations replaces Buddhist nun according to Shandong, and HPLC purity is 99.6%, and all impurity are equal
Less than 0.1%.
Embodiment 5
Take and replace Buddhist nun crude product 15g according to Shandong according to prepared by embodiment 1,400ml methyl alcohol is dissolved under stirring, under being stirred after dissolving
100ml water is added dropwise over, 4h is kept stirring for after adding, be filtrated to get solid, 30 DEG C of vacuum dryings.
Learn from else's experience and add 25ml acetone and 25ml normal heptanes for Buddhist nun 10g according to Shandong after drying, 3h is stirred at room temperature, be filtrated to get
Solid, room temperature in vacuo dries 6h, and obtain A crystal formations replaces Buddhist nun according to Shandong, and sample HPLC purity is 99.7%, and all impurity are below
0.1%.
Embodiment 6
Take and replace Buddhist nun crude product 30g according to Shandong according to prepared by embodiment 1,100ml methyl alcohol is dissolved under stirring, under being stirred after dissolving
100ml water is added dropwise over, 3h is kept stirring for after adding, be filtrated to get solid, 50 DEG C of vacuum dryings.
Learn from else's experience and add 50ml acetone and 200ml normal heptanes for Buddhist nun 5g according to Shandong after drying, 4h is stirred at room temperature, be filtrated to get
Solid, 50 DEG C of vacuum drying 8h, obtain A crystal formations replaces Buddhist nun according to Shandong, and sample HPLC purity is 99.7%, and all impurity are below
0.1%.
Embodiment 7
Carry out X-ray powder diffraction for Buddhist nun's sample according to Shandong by what embodiment 2~6 was obtained, collection of illustrative plates 2- θ values be 5.7 ±
There is characteristic peak at 0.1 °, 13.6 ± 0.1 °, 16.1 ± 0.1 °, 18.9 ± 0.1 °, 21.3 ± 0.1 ° and 21.6 ± 0.1 °, and specially
The crystal formation A of profit application CN104736178A is consistent.The sample collection of illustrative plates of embodiment 3 refers to accompanying drawing 1.
Claims (10)
1. it is a kind of be adapted to it is medicinal according to Shandong for Buddhist nun preparation method, it is characterised in that：
(1) first crystallized with methyl alcohol, water mixed solvent；
(2) use acetone, normal heptane mixed solvent crystallization, the acetone, normal heptane mixed solvent and Yi Lu again is for the ratio of Buddhist nun
5ml/g~50ml/g；
(3) removal recrystallisation solvent is dried, is obtained and is adapted to medicinal replace Buddhist nun according to Shandong.
2. method according to claim 1, it is characterised in that：Methyl alcohol, water volume ratio described in the step (1) are 1:1
~10:1.
3. method according to claim 1, it is characterised in that：Methyl alcohol described in the step (1), water mixed solvent and according to
Shandong is 1ml/g~100ml/g for the ratio of Buddhist nun.
4. method according to claim 1, it is characterised in that：Acetone, normal heptane volume ratio are 1 in the step (2):1
~1:10.
5. method according to claim 1, it is characterised in that：The drying mode is vacuum drying.
6. method according to claim 1, it is characterised in that：The vacuum drying temperature is 10 DEG C~70 DEG C.
7. method according to claim 1, it is characterised in that：
(1) take according to Shandong for Buddhist nun's crude product, it is 1 to add volume ratio:1~4:1 methyl alcohol, water mixed solvent, are filtrated to get after being sufficiently stirred for
Solid, vacuum drying；
(2) to learn from else's experience and add volume ratio 1 for Buddhist nun according to Shandong after drying:1~1:4 acetone, normal heptane mixed solvent, mistake after being sufficiently stirred for
Filter obtains solid, and the acetone, normal heptane mixed solvent and Yi Lu are 5ml/g~50ml/g for the ratio of Buddhist nun；
(3) vacuum drying removal recrystallisation solvent, obtains and is adapted to medicinal replace Buddhist nun according to Shandong.
8. method according to claim 1, it is characterised in that：
(1) take according to Shandong for Buddhist nun's crude product, it is 1 to add volume ratio:1~4:1 methyl alcohol, water mixed solvent, are filtrated to get after being sufficiently stirred for
Solid, 25 DEG C~50 DEG C vacuum dryings；
(2) to learn from else's experience and add volume ratio 1 for Buddhist nun according to Shandong after drying:1~1:4 acetone, normal heptane mixed solvent, mistake after being sufficiently stirred for
Filter obtains solid, and the acetone, normal heptane mixed solvent and Yi Lu are 5ml/g~50ml/g for the ratio of Buddhist nun；
(3) 25 DEG C~50 DEG C vacuum drying removal recrystallisation solvents, obtain and are adapted to medicinal replace Buddhist nun according to Shandong.
9. it is a kind of be adapted to it is medicinal replace Buddhist nun according to Shandong, it is prepared by any one of the claim 1~8 method.
10. one kind replaces Buddhist nun's preparation according to Shandong, medicinal with one or more for Buddhist nun according to Shandong described in the claim 9 by therapeutically effective amount
Auxiliary material is mixed.
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| CN201510980745.3A CN106905320A (en) | 2015-12-23 | 2015-12-23 | It is a kind of to be adapted to medicinal replace Buddhist nun and its preparation according to Shandong |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108707154A (en) * | 2018-07-10 | 2018-10-26 | 刘凤娟 | A kind of drug solvent for the treatment of cancer closes object and preparation method thereof |
| CN115124536A (en) * | 2022-07-02 | 2022-09-30 | 浙江美诺华药物化学有限公司 | Synthesis method of ibrutinib intermediate |
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| CN104736178A (en) * | 2012-06-04 | 2015-06-24 | 药品循环公司 | Crystalline forms of a Bruton's tyrosine kinase inhibitor |
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| CN103694241A (en) * | 2013-11-27 | 2014-04-02 | 苏州晶云药物科技有限公司 | Novel crystal form A of PCI-32765 and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108707154A (en) * | 2018-07-10 | 2018-10-26 | 刘凤娟 | A kind of drug solvent for the treatment of cancer closes object and preparation method thereof |
| CN115124536A (en) * | 2022-07-02 | 2022-09-30 | 浙江美诺华药物化学有限公司 | Synthesis method of ibrutinib intermediate |
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