CN106902076A - 一种通用乳膏基质及其临方调剂 - Google Patents
一种通用乳膏基质及其临方调剂 Download PDFInfo
- Publication number
- CN106902076A CN106902076A CN201710176072.5A CN201710176072A CN106902076A CN 106902076 A CN106902076 A CN 106902076A CN 201710176072 A CN201710176072 A CN 201710176072A CN 106902076 A CN106902076 A CN 106902076A
- Authority
- CN
- China
- Prior art keywords
- parts
- emulsifiable paste
- component
- general
- paste matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Insects & Arthropods (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及皮肤外用制剂领域,尤其是公开了一种通用乳膏基质及其临方调剂。本发明的技术方案为:一种通用乳膏基质,组分及各组分的配比如下:340B、鲸蜡硬脂基葡萄糖苷/鲸蜡醇硬脂醇等;尿囊素、N琥珀酰壳聚糖等;透明质酸钠等;中药液、化学原料、鲜桦树液。本发明具有操作简便易行的优点。
Description
技术领域
本发明涉及皮肤外用制剂领域,尤其是公开了一种通用乳膏基质及其临方调剂。
背景技术
乳膏剂是软膏剂其中一种类型,中药乳膏剂是用中药提取物、少量中药饮片细粉加乳化剂为基质制成的产品;化学原料乳膏剂是指化学原料溶解或分散于乳剂型基质一定稠度的半固体制剂。乳膏剂是中药和化学原料外用制剂调剂最广泛的制剂,主要有保护创面、润滑皮肤和局部治疗作用。是皮肤科、皮肤美容科、化妆品应用最广泛的外用制剂,适用于各种急性、亚急性或慢性炎症性皮肤病,因膏体细腻、清爽、润滑,深受医者和患者的青睐。乳膏是一种老剂型,随着现代科学的发展,基质亟待更新;中药乳膏剂的配制受到重视,发展迅速,国家部署中医、中西医结合医疗机构建立中药临方调剂室,乳膏剂为重要剂型,而高浓度中药不能乳化,制约发展难题亟待解决;当前供临方调剂的乳膏均为低端产品,加中药极少,几无作用,亟待开发高端功能性乳膏产品;乳膏剂因其成分数种或数十种,配置齐全较困难,且配制技术复杂,一般卫生技术人员不易操作。
发明内容
本发明目在于克服现有技术存在的不足,提供一种通用乳膏基质及临方调剂,先制成通用乳膏基质,将数十种操作简化成一种,根据需要添加中药液、化学原料、桦树液配成乳膏。简便易行,医师、药师、美容师,甚至人民群众皆可操作。
为了解决上述技术问题,本发明采用的技术方案为:一种通用乳膏基质,组分及各组分的配比如下:
340B为20~50份、甘油硬脂酸酯 / PEG-100硬脂酸酯10~15份、鲸蜡硬脂基葡萄糖苷 /鲸蜡醇硬脂醇5~10份、肉豆蔻酸异丙酯25~35份、鲸蜡硬酯醇25~35份、聚二甲基硅氧烷10~20份、霍霍巴油5~15份、角鲨烷15~25份、蜂蜡40~60份、马脂5~15份、鸸鹋油5~15份、奶油5~15份、月桂氮䓬酮5~15份、维生素E为5~10份、丙二醇10~30份、丁基羟基茴香醚0.1~0.2、丁羟甲苯0.1~0.2;尿囊素2~3份、N琥珀酰壳聚糖5~15份、氨基酸保湿剂10~20份、海藻糖10~20份、木糖醇20~30、甘油20~40份、5%透明质酸钠丁二醇溶液15~20份、水解蜂王浆蛋白5~10份、K350为2.5~4份、10%氯苯甘醚丁二醇溶液15~25份、乙二胺四乙酸二钠0.1~0.15份、亚硫酸氢钠0.2~0.25份、鲜桦树液5~10份、中药煎液150~170份。
采用本方案,开拓性的将传统基质中的水全部改用桦树液,符合、贯彻、落实《中华人民共和国中医药法》:“国家鼓励医疗机构根据本医疗机构临床用药需要配制和使用中药制剂,支持应用传统工艺配制中药制剂,支持以中药制剂为基础研制中药新药”的规定,符合用植物汁临方调剂外用制剂的规定,用现代科技进行创新。鲜桦树液为天然桦树躯干纤维组织中自然形成的汁液,贮量丰富,来源广泛,采集方便,是一种无色透明液体,经研究桦树液含有丰富的营养物质,以白桦液为例,其中的干物质含量为1.31%,还原糖含量为0.43%,苏氨酸454.0% ,谷氨酸8789.1 mg/L,甘氨酸744.9 mg/L,丙氨酸1895.6 mg/L,缬氨酸934.1 mg/L,异亮氨酸313.9 ms/L,亮氨酸566.1 mg/L,酪氨酸369.3 mg/L,苯丙氨酸474.4mg/L,组氨酸2712.7 mg/L,赖氨酸325.3 mg/L。桦树汁中的微量元素也很丰富,对人体有益的钾、钠、钙、镁、铁、锰、锌等含量较高。王云芳,许国英等对新疆布尔津平原林场的春采白桦树液的化学成分进行了研究,其干物质含量为1.36~1.42%,pH值5.69~6.44,总氮含量为4.5~9.5mg/l00rnl,总氨基酸含量20~30mg/l00ml,总糖含量1.1~1.4%,以果糖和葡萄糖为主,总酸含量25~55mg/l00ml,含有维生素C、B1、B2、PP等。并含有丰富的微量元素铜、铁、锌、锰等.特别是富含有半金属元素硒。H.Kallio报道芬兰桦树液4月初—5月初葡萄糖和果糖浓度最高,达5~8mg/ml,而新疆桦树液3月底-4月中旬葡萄糖与果糖总浓度可达7.00~13.84mg/ml。以新疆白桦树液经急性毒性试验、Ames试验、微核试验、***畸形试验,证实新疆白桦树液无致死毒性和诱变性。陈铁山对秦岭桦树液进行了营养成分的测定分析,其总糖含量为0.813% ,蛋白质含量0.03%,含有维生素B1、B2、C、E,16种氨基酸以及钾、钙、镁、磷、硒、锌、锶、锗、锗等15种矿质营养成分和微量元素成分,其中含有机锗0.181mg /L。众所周知有机锗使细胞活性化,具有延寿的作用。有机锗既是氧的催化剂又是抗氧化剂,提高SOD活性,减少皮肤中不溶性胶原的含量,从而保持皮肤的弹性,减少皱纹的生成,可清除体内垃圾,排除体内重金属,达到排毒养颜的作用。用于皮肤护品,由于它稳定性的特点对化妆品是很重要的。有机锗用于美容或化妆品可以制成不同的剂型,如乳剂、软膏、水剂、粉剂等,用含有0.5%有机锗钠盐对32~60岁有皮肤色素沉着的妇女实验,结果表明试测者皮肤变得光滑、丰润,小皱纹消失,色素及斑点改善,有机锗配成乳液加入必要的配料,涂手及面部,皮肤变得光滑而未产生过敏及其它副作用。外用具有杀菌,收敛,保湿,润泽皮肤,去除粉刺,减少色斑,祛头屑,健发,生发的作用,入药可治疗外伤、皮肤溃疡、湿疹皮炎、脱发、毒虫咬伤、银屑病、皮肤皲裂等。
本方案中,首先采用复合乳化剂,其中,
A、340B由脂肪醇聚氧乙烯醚、甘油脂肪酸酯和植物蜡组成的复合物,为非离子乳化剂,具有耐热、耐电解质、耐酸、耐碱、耐中药特性,乳化能力强,有乳化、增稠、保湿、调理和调节流变性功效。
B、甘油硬脂酸酯 / PEG-100硬脂酸酯,为非离子自乳化单甘酯,乳化能力强,在含酸性或电解质的配方中同样稳定,与鲸蜡硬脂基葡萄糖苷 / 鲸蜡醇硬脂醇复配,可达到满意效果,手感柔滑滋润,适宜于配制婴儿霜、抗粉刺霜、面霜等产品。
C、鲸蜡硬脂基葡萄糖苷 / 鲸蜡醇硬脂醇,为非离子糖基乳化剂,具有卓越的乳化能力,有液晶特性,能产生晶莹明亮的膏体,手感柔滑、滋润,体现出高水合性,在酸性或含电解质的配方稳定性好,具备优良的生物降解性能和天然、温和、安全的特点,适用于配制保湿霜等产品,可用于各种类型的皮肤。
D、肉豆蔻酸异丙酯为乳化剂、保湿剂,是高档乳膏的重要添加成分之一,对皮肤有极好的渗透、滋润和软化作用。
赋型剂、增稠剂使用有乳化作用的蜂蜡、鲸蜡硬脂醇,而不用化工产品凡士林,特别适用中药和功效产品。
其次,包含功效性原料保湿剂,具体包括丙二醇10~30份、丁二醇30~45份、甘油20~40份、尿囊素2~3份、N琥珀酰壳聚糖5~15份、氨基酸保湿剂10~20份、海藻糖10~20份、木糖醇20~30份、5%透明质酸钠丁二醇溶液10~20份,丙二醇、丁二醇、甘油、N琥珀酰壳聚糖表观保湿;尿囊素角质层保湿;透明质酸钠、氨基酸保湿剂、海藻糖角质层、深层保湿,合用达到全层保湿作用。保湿为皮肤保健、美容、治疗皮肤病的基础。其各主要成分的功效及药理依据如下:
A、丙二醇润肤、保湿,有防腐作用,可增强羟苯酯类防腐能力,吸水性比甘油少,湿度大时皮肤水质感强,清爽,清洁,增溶性好。是化学原料的良好溶剂。
B、丁二醇保湿、抑菌,较甘油好,用后干爽。是化学原料的良好溶剂。
C、甘油是传统保湿剂、助悬赋形剂,吸水性好,温度大时皮肤水分大,浓度高时黏稠、吸水。
D、尿囊素保湿,具有促进细胞生长,加快伤口愈合,软化角质蛋白等生理功能,是皮肤创伤的良好愈合剂和抗溃疡药剂。可用作缓解和治疗皮肤干燥症、鳞屑性角化性皮肤疾患、皮肤溃疡及炎症,对痤疮均有较好疗效。
E、N琥珀酰壳聚糖源于海洋生物所含壳聚糖的酰化衍生物,增加天鹅绒般的柔软感觉,增强修复作用,有利于受损细胞的修复和生长。
F、氨基酸保湿剂为天然保湿剂,保持肌肤滋润、光滑。
G、海藻糖易于皮肤吸收,进入细胞内发挥其独特的水替代应激因子,保护细胞膜功能,抗干燥保湿。
H、木糖醇保湿,使皮肤增白,保持皮肤的光滑滋润。
I、透明质酸钠,本身是人体皮肤的构成之一,是人体内分布最广的一种酸性黏糖,具有良好的保湿作用,广泛应用于高档化妆品及皮肤保健品,为***仿生化妆品添加剂,保持皮肤滋润、光滑,修复受损皮肤,涂后清爽。
再次,马脂5~15份、鸸鹋油5~15份、奶油5~15份、水解蜂王浆蛋白5~10份,其各原料中主要成分的功效及药理依据如下:
A、马脂(马油),《黄帝内经》记载马油,具有改善肌肤干裂功效。陶弘景《名医别录》提及马油可促生毛发。李时珍《本草纲目》曰:“鬐膏(鬐,马项上鬐也),甘,平,有小毒。生发,治面黚,手足皴粗。” 20世纪80年代风行于日本,是将马鬃毛下或脖颈处的脂肪提炼成马脂原油,再配以油酸、亚油酸和棕榈酸而制成现代马脂,对皮肤亲和性佳,渗透性最好,外涂无油腻感。日本厚生省1985年认可马油是“皮肤保护的健康油”,其中主要组分油酸和亚油酸总含量为50%,还含维生素E、A,微量元素等。有护肤、润肤、保湿、抗炎、生发、祛斑功效。马油近年制成高级化妆品,用于润肤、护肤、美容和治疗某些皮肤病。
B、鸸鹋油,鸸鹋油中的不饱和脂肪酸和亚麻酸,有强力渗透,舒缓疲劳,松弛肌肉,促进再生,修复受损,滋润皮肤,淡化皱纹功效。用于瘢痕疙瘩、皮肤皲裂、角化性皮肤病。
C、奶油,又称奶酥油,是以牛(羊)乳脂肪为主的一种乳制品,自古至今都是药食两用奶制品,为淡黄色半固体,含脂肪80%以上,古希腊人和古罗马人制作的奶油大部分作为化妆品涂搽在脸上。为印度医学和藏医学、蒙医学的主要药品之一,元•忽思慧《饮膳正要》载:“酥油,牛乳中取净凝,熬而为酥。”《医宗金鉴•外科心法要诀》作为润肌膏成分,与人皮脂相似,有润肤护肤功效,用于鳞屑角化性皮肤病。
D、水解蜂王浆蛋白,是现代高科技工艺从蜂王浆中提取,易于吸收。含有12种以上蛋白质、20多种氨基酸、10多种维生素,SOD酶,不但是营养滋补品,而且具有显著的美容功效。所含的大量活性物质能激活酶***,使脂褐素排出体外,降低其含量。而且蜂王浆还具有抗菌、消炎、抗辐射、抗氧化的作用,可预防皮肤感染、发炎及辐射损伤,阻止皮肤黑色素的形成,防止及去除皱纹,祛斑,护理皮肤,保持皮肤清洁白皙,长期使用,皮肤红润、光泽、靓丽。
此外,聚二甲硅氧烷10~20份、霍霍巴油5~15份、角鲨烷15~25份、维生素E为 5~10份,作为润肤剂均有保持皮肤润泽光滑的作用。
抗氧剂选用丁基羟基茴香醚0.1~0.2份、丁羟甲苯0.1~0.2份、维生素E 5~10份,维生素E溶于油,用于油脂抗氧化,乙二胺四乙酸二钠、亚硫酸氢钠溶于水,用于桦树汁和中药抗氧化。
防腐剂用10%氯苯氨醚丁二醇溶液15~25份、K340 2.5~4份,其中K340为羟苯甲酯、羟苯乙酯、苯氧乙醇、乙基已基甘油、丙二醇复配的复合防腐剂成品;复合使用,增强抗真菌、抗细菌效果。
采用本通用基质,制备的临方调剂如下:
进一步的,采用所述的一种通用乳膏基质制备的复方甘草乳膏,组分及其各组分配比如下:通用乳膏基质500份、甘草80份、黄芩50份、马齿苋20份,制成煎液350~450份,桦树液50~100份。此方中,各主要成分的功效及药理依据如下:
A、甘草,甘,平。具有清热解毒,调和诸药功效。含甘草酸、甘草黄酮、甘草酸二钾等成分,有类似糖皮质激素作用,抗过敏,用于湿疹皮炎等皮肤病。
B、黄芩,苦,寒。具有清热燥湿,泻火解毒,凉血止血功效。含黄芩苷、黄芩素、黄酮类化合物,有抗炎、抗菌、抗过敏、收敛、抑制渗出作用,用于痈肿疮毒、湿疹皮炎、银屑病等皮肤病。
C、马齿苋,酸,寒。具有清热解毒,凉血消肿功效。含黄酮类、微量元素、维生素等,有抗菌消炎作用,用于痈肿疔疮、丹毒、毒虫咬伤、湿疹等皮肤病。
进一步的,采用所述的一种通用乳膏基质制备的生地黄乳膏,组分及其各组分配比如下:通用乳膏基质500份、生地黄28份、黄连35份、白蔹14份、芍药14份、白及14份,苦参21份、升麻21份、鲜桦树液50~200份。此方中,纳诸药同熬,膏成去滓,候凝敷之。有清热凉血,解毒止痛功效。主治热疮,类似单纯疱疹、疱疹样脓疱病等感染性皮肤病。
进一步的,采用所述的一种通用乳膏基质制备的十白乳膏,组分及其各组分配比如下:通用乳膏基质 500份、十白液300~450份、水解珍珠液50~100份、鲜桦树液50~200份。
其中,所述的十白乳膏,所述十白液为香白芷、白蔹、白术、玉竹各30 g;去皮的白茯苓,生白僵蚕、白附子、细辛各9 g;白及15 g,制成煎液300~450份。
此方中,所述十白乳膏,源于七白膏,相传起源于唐,成于宋、元,为宫廷方。记载于宋《太平圣惠方》和元《御药院方》中。组方:香白芷、白蔹、白术各一两(30 g),白及半两(15g),白茯苓(去皮)、白附子(生)、细辛(去叶、土)各三钱(9 g)。方中六味白字药,为美白药方,故名七白膏,方中白术、白茯苓益脾渗湿、驻颜祛斑,白芷、细辛散风除湿、活血止痒,白蔹散结消肿、疗面上疱疮,白及化瘀生肌、愈皮肤皲裂,白附子主面上百病、除斑秽疵、行诸药势。全方配伍周详,不仅能消散面部黑气,还能改善面部皮肤肌肉的功能状态,使之“光润不皱”,确为祛斑良方。我国古代美白外用药方中大多数含七白膏及其他白色中药成分,中医以白美白、祛斑为基本法则,可见白色中药的作用,又加白僵蚕、玉竹、水解珍珠液。白僵蚕在《神农本草经》载有“灭黑斑,令人面色好”的功效,《本草纲目》称白僵蚕:“蜜和擦面,灭黑黯好颜色。”含有氨基酸和活性丝光素,有营养皮肤、防治瘢痕、祛粉刺、祛瘀斑美容作用。珍珠解毒生肌,抗衰驻颜,润肤白面,历来为美白要药,经现代工艺制成水解珍珠液。玉竹养阴润燥,清热生津,润肤美白,被药王孙思邈纳入美容方中。七白再加三白谓十白乳膏,用于黄褐斑、皮肤黑变病,日常皮肤保健、增白、祛斑。
进一步的,采用所述的一种通用乳膏基质制备的颠倒乳膏,组分及其各组分配比如下:通用乳膏基质 500份、大黄煎液150~300份、鲜桦树液200~350份。
其中,所述的颠倒乳膏,所述大黄煎液为大黄50~100 g,制成煎液150~300份。
进一步的,采用所述的一种通用乳膏基质制备的氢化可的松乳膏,组分及其各组分配比如下:通用乳膏500份、鲜桦树液350~475份、氢化可的松5~10份、丁二醇20~40份。
所述氢化可的松乳膏,氢化可的松为弱糖皮质激素类药,有抗过敏、抗炎作用,为皮肤科常用药,与功效性通用乳膏基质复配成中西药结合产品,用于湿疹皮肤、特应性皮炎、瘙痒症等。
进一步的,采用所述的一种通用乳膏基质制备的水杨酸乳膏,组分及其各组分配比如下:通用乳膏500份、鲜桦树液200~500份、水杨酸20~100份。所述水杨酸乳膏,使用水溶性水杨酸,溶于水,用耐酸通用乳膏基质复配,解决了水杨酸耐酸、水溶问题。水溶性水杨酸低浓度保湿、促进角质形成,高浓度剥脱换肤,强于果酸。用于角化性皮肤病、色素性皮肤病、痤疮等。
本发明与现有技术相比有以下有益效果:
1、开创性的用鲜桦树液代替传统基质中的水;
2、选用复合乳化剂340B 20~50份、甘油硬脂酸酯 / PEG-100硬脂酸酯10~15份、鲸蜡硬脂基葡萄糖苷 / 鲸蜡醇硬脂醇5~10份、肉豆蔻酸异丙酯25~35份,弃用了传统的甘油硬脂酸酯、硬脂酸、月桂醇硫酸酯钠、十二烷基钠等,使其乳化能力极大增强,膏体手感好,细腻、柔滑、滋润、亮丽。
具体实施方式
下面实施例,对本发明的具体实施方式作进一步详细描述,以下实施例用于说明本发明,但不用来限制本发明的范围。
实施例1:
一种通用乳膏基质,A组分:340B为25份、甘油硬脂酸酯 / PEG-100硬脂酸酯10份、鲸蜡硬脂基葡萄糖苷 / 鲸蜡醇硬脂醇10份、肉豆蔻酸异丙酯30份、鲸蜡硬脂醇30份、聚二甲基硅氧烷15份、霍霍巴油10份、角鲨烷20份、蜂蜡30份、马油10份、鸸鹋油10份、奶油10份、月桂氮䓬酮15份、维生素E为10份、丙二醇15份、丁基羟基茴香醚0.15份、丁羟甲苯0.15份,B组分:尿囊素3份、N琥珀酰壳聚糖10份、氨基酸保湿剂10份、海藻糖10份、木糖醇25份、鲜桦树液119份、甘油20份,C组分:C1溶液5%透明质酸钠丙二醇溶液20份、C组分2:水解蜂王浆蛋白5份、C3溶液K350为2.5份、C4溶液10%氯苯甘醚丙二醇溶液15份、C5溶液乙二胺四乙酸二钠0.1份、亚硫酸氢钠0.25份、鲜桦树液5份。
其制备方法包括以下步骤:
1、将A组分中的340B、甘油硬脂酸酯 / PEG-100硬脂酸酯、鲸蜡硬脂基葡萄糖苷 / 鲸蜡醇硬脂醇、肉豆蔻酸异丙酯、鲸蜡硬脂醇、聚二甲基硅氧烷、霍霍巴油、角鲨烷、蜂蜡、马油、鸸鹋油、奶油、月桂氮䓬酮、维生素E、丙二醇、丁基羟基茴香醚、丁羟甲苯按照上述比例混合,水浴加热至83℃,制得A组分溶液备用;
2、将B组分中的尿囊素、N琥珀酰壳聚糖、海藻糖、木糖醇、鲜桦树液、甘油按照上述比例混合,水浴加热至90℃,保持20分钟消毒灭菌,降至85℃,制得B组分溶液备用;
3、将5%透明质酸钠丙二醇溶液加温至50℃, 制得C1溶液备用;
4、将10%氯苯甘醚丙二醇溶液加温至50℃,制得C4溶液备用;
5、将乙二胺四乙酸二钠、亚硫酸氢钠、鲜植物汁按照上述比例混合,加温至50℃,制得C5溶液备用;
6、A组分溶液加入B组分溶液烧杯中混合,边加边顺时针搅拌2分钟,初乳开成,均质3分钟;冷水浴降温至50~45℃,依次加入同温的C 1溶液、C 2溶液、C3溶液、C 4溶液、C 4溶液,边加边搅拌,搅拌至36℃,即成。
实施例2:
一种复方甘草乳膏,其原料组成的配比关系、制备如下。
配方:乳膏基质500g,复方甘草煎液350g,鲜桦树液加至1000g。
制备复方地黄煎液:甘草80g、黄芩50g、马齿苋20g,制成煎液350g,过滤备用;
取乳膏基质 500g、复方甘草煎液350g加入烧杯中,鲜桦树液加至1000g,加热至75~83℃,边加热边顺时针搅拌2分钟,初乳形成,均质3分钟;冷水浴降温,搅拌至36℃,即成。
实施例3:
一种生地黄乳膏,其原料组成的配比关系、制备如下。
配方:乳膏基质500g,复方地黄煎液350g,鲜桦树液加至1000g。
制备复方地黄煎液:生地黄28g,黄连35g,白蔹、芍药、白及各14g,苦参、升麻各21g,制成煎液350g,过滤备用;
取乳膏基质 500g、复方地黄煎液350g加入烧杯中,鲜桦树液加至1000g,加热至75~83℃,边加热边顺时针搅拌2分钟,初乳形成,均质3分钟;冷水浴降温,搅拌至36℃,即成。
实施例4:
一种十白乳膏,其原料组成的配比关系、制备如下。
配方:乳膏基质500g,十白煎液350g,水解珍珠液50g,鲜桦树液加至1000g。
制备十白煎液:香白芷、白蔹、白术、玉竹各30 g,白茯苓(去皮)、生白僵蚕、白附子、细辛(去叶、土)各9 g,白及15 g,制成十白煎液350g,过滤备用;
取乳膏基质 500g、十白煎液加入烧杯中,鲜桦树液加至950g,加热至75~83℃,边加热边顺时针搅拌2分钟,初乳开成,均质3分钟;冷水浴降温至50~45℃,加水解珍珠液50g,搅拌至36℃,即成。
实施例5
一种颠倒乳膏,其原料组成的配比关系、制备如下。
配方:乳膏基质500g,大黄煎液150g,升华硫50g,丁二醇50g,鲜桦树液加至1000g。
制备大黄煎液:大黄50g,制成约150g左右煎液,过滤备用;
取升华硫50g,加60℃丁二醇50g、鲜桦树液50g混合物,置乳钵中研磨,分散成糊状,制成升华硫分散物备用。
取乳膏基质500g、大黄煎液150g左右加入烧杯中,鲜桦树液加至850g,加热至75~83℃,边加热边顺时针搅拌2分钟,初乳开成,均质3分钟;冷水浴降温至60~50℃,加升华硫分散物150g,搅拌至36℃,即成。
实施例6
一种氢化可的松乳膏,其原料组成的配比关系、制备如下。
配方:乳膏基质500g,氢化可的松5g,丁二醇15g,鲜桦树液加至1000g。
氢化可的松5g,加60℃丁二醇15g置乳钵中研磨,分散成糊状,制成氢化可的松分散物备用。
取乳膏基质500g、鲜桦树液480g加入烧杯中,加热至75~83℃,边加热边顺时针搅拌2分钟,初乳开成,均质3分钟;冷水浴降温至60~50℃,加同温氢化可的松分散物,搅拌至36℃,即成。
实施例7
一种水杨酸乳膏,其原料组成的配比关系、制备如下。
配方:乳膏基质 500g,水溶性水杨酸100g,鲜桦树液400g。
调剂方法是取乳膏基质500份,加入烧杯中,加热至83℃备用;
另取鲜桦树液400g,水溶性水杨酸100g,混合、加热至85℃备用。
乳膏基质液加入水溶性水杨酸、鲜桦树液液混合,加热至83℃,边加热边顺时针搅拌2分钟,初乳形成,均质3分钟;搅拌至36℃,即成。
本发明将几十种新型原料和功能性原料合成通用乳膏基质,再按1︰1比例添加中药、化学原料、鲜桦树液,即可临方调剂成乳膏,为使用者简化了数十道操作程序,适用于医疗机构临方调剂,人人皆能操作。以鲜桦树液置转换水,贯彻、执行《中医药法》,临方调剂中药,解决中药乳化难题,辨证施治,添加功能性原料,使乳膏具备和增强功效性。
以上所述仅为本发明的优选实施例而已,并不用于限制本发明,尽管参照前述实施例对本发明进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (9)
1.一种通用乳膏基质,其特征在于,组分及各组分的配比如下: 340B为20~50份、甘油硬脂酸酯 / PEG-100硬脂酸酯10~15份、鲸蜡硬脂基葡萄糖苷 / 鲸蜡醇硬脂醇5~10份、肉豆蔻酸异丙酯25~35份、鲸蜡硬酯醇25~35份、聚二甲基硅氧烷10~20份、霍霍巴油5~15份、角鲨烷15~25份、蜂蜡40~60份、马脂5~15份、鸸鹋油5~15份、奶油5~15份、月桂氮䓬酮5~15份、维生素E为5~10份、丙二醇10~30份、丁基羟基茴香醚0.1~0.2、丁羟甲苯0.1~0.2;尿囊素2~3份、N琥珀酰壳聚糖5~15份、氨基酸保湿剂10~20份、海藻糖10~20份、木糖醇20~30、甘油20~40份、5%透明质酸钠丁二醇溶液15~20份、水解蜂王浆蛋白5~10份、K350为2.5~4份、10%氯苯甘醚丁二醇溶液15~25份、乙二胺四乙酸二钠0.1~0.15份、亚硫酸氢钠0.2~0.25份、鲜桦树液5~10份、中药煎液150~170份。
2.采用权利要求1所述的一种通用乳膏基质制备的复方甘草乳膏,其特征在于,组分及其各组分配比如下:通用乳膏基质500份,甘草80份、黄芩50份、马齿苋20份,制成煎液350~450份,鲜桦树液100~150份。
3.采用权利要求1所述的一种通用乳膏基质制备的生地黄乳膏,其特征在于,组分及其各组分配比如下:通用乳膏基质500份、生地黄28份、黄连35份、白蔹14份、芍药14份、白及14份,苦参21份、升麻21份、鲜桦树液50~200份。
4.采用权利要求1所述的一种通用乳膏基质制备的十白乳膏,其特征在于,组分及其各组分配比如下:通用乳膏基质 500份、十白液300~450份、水解珍珠液50~100份、鲜桦树液50~200份。
5.如权利要求4所述的十白乳膏,其特征在于:所述十白液为香白芷、白蔹、白术、玉竹各30 g;去皮的白茯苓,生白僵蚕、白附子、细辛各9 g;白及15 g,制成煎液300~450份。
6.采用权利要求1所述的一种通用乳膏基质制备的颠倒乳膏,其特征在于,组分及其各组分配比如下:通用乳膏基质 500份、大黄煎液50~100份、鲜桦树液200~350份。
7.如权利要求6所述的颠倒乳膏,其特征在于:所述大黄煎液为大黄50~100 g,制成煎液150~300份。
8.采用权利要求1所述的一种通用乳膏基质制备的氢化可的松乳膏,其特征在于,组分及其各组分配比如下:通用乳膏500份、鲜桦树液350~475份、氢化可的松5~10份、丁二醇20~40份。
9.采用权利要求1所述的一种通用乳膏基质制备的水杨酸乳膏,其特征在于,组分及其各组分配比如下:通用乳膏500份、鲜桦树液200~500份、水杨酸20~100份。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710176072.5A CN106902076A (zh) | 2017-03-23 | 2017-03-23 | 一种通用乳膏基质及其临方调剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710176072.5A CN106902076A (zh) | 2017-03-23 | 2017-03-23 | 一种通用乳膏基质及其临方调剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106902076A true CN106902076A (zh) | 2017-06-30 |
Family
ID=59195583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710176072.5A Pending CN106902076A (zh) | 2017-03-23 | 2017-03-23 | 一种通用乳膏基质及其临方调剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106902076A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110934788A (zh) * | 2019-12-04 | 2020-03-31 | 广州阳菲生物科技有限公司 | 一种植物神经酰胺协同修护皮肤的组合物、化妆品及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1091645A (zh) * | 1993-03-02 | 1994-09-07 | 刘国栋 | 治疗支气管炎、哮喘病药及其制造方法 |
CN105456049A (zh) * | 2015-11-17 | 2016-04-06 | 广东医学院 | 具有消炎止痛护肤作用的辅酶q10按摩膏 |
CN106137865A (zh) * | 2016-08-23 | 2016-11-23 | 北京神桦生物科技有限公司 | 一种桦树液小分子团水保湿水 |
-
2017
- 2017-03-23 CN CN201710176072.5A patent/CN106902076A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1091645A (zh) * | 1993-03-02 | 1994-09-07 | 刘国栋 | 治疗支气管炎、哮喘病药及其制造方法 |
CN105456049A (zh) * | 2015-11-17 | 2016-04-06 | 广东医学院 | 具有消炎止痛护肤作用的辅酶q10按摩膏 |
CN106137865A (zh) * | 2016-08-23 | 2016-11-23 | 北京神桦生物科技有限公司 | 一种桦树液小分子团水保湿水 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110934788A (zh) * | 2019-12-04 | 2020-03-31 | 广州阳菲生物科技有限公司 | 一种植物神经酰胺协同修护皮肤的组合物、化妆品及其应用 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101125119B (zh) | 一种具有美白抗衰老的藏本草提取物及其应用 | |
CN102293733B (zh) | 美白祛斑护肤产品 | |
CN111202695A (zh) | 一种天然可食用的具有保健功能的组合物及其应用、彩妆化妆品及其制备方法 | |
KR101373636B1 (ko) | 천연물 복합 발효 추출물을 유효성분으로 하는 피부 및 두피 상태 개선용 조성물 | |
CN105395467B (zh) | 一种中药组合物、美肤化妆品及其应用 | |
CN103585097B (zh) | 一种白及多糖载表皮生长因子复合物及其制备方法和应用 | |
CN103340817B (zh) | 一种葛根美白面膜 | |
CN109662928A (zh) | 一种具有防晒修复功效的护肤组合物及其应用和制备方法 | |
CN107334726A (zh) | 一种祛痘组合物及其制备方法和应用 | |
CN102274141B (zh) | 复活草水活保湿霜及其制备方法 | |
CN108653006A (zh) | 一种植物保湿全效眼霜及其制备方法 | |
KR20170112750A (ko) | 프로폴리스 미세침 분말을 함유하는 화장료 조성물 | |
CN104434618A (zh) | 兼具美白、祛斑印功效的九草绿霜及其制备方法 | |
WO2018000665A1 (zh) | 一种能让***丰满紧致和预防乳腺疾病的精华液 | |
CN108114074A (zh) | ***消肿止疼川穹鲜药提取组合物、鲜药油及其制备方法 | |
CN108670933B (zh) | 兼具保湿、美白、抗衰老的护肤组合物及其应用 | |
KR20140145278A (ko) | 피부 수렴 및 탄력 효과를 갖는 승마 추출물, 산수유 추출물 및 현초 추출물을 함유하는 화장료 조성물. | |
KR20090066230A (ko) | 피부 주름 개선 및 피부 수렴 작용을 갖는 혼합 식물추출물을 함유한 화장료 조성물 및 그 제조방법 | |
CN113133967A (zh) | 一种牡丹精华液润肤面乳及其制备方法 | |
CN104013549B (zh) | 一种含中华金丝提取物的护肤品 | |
CN105342966A (zh) | 含有日本医蛭的护肤保湿霜及其制备方法 | |
CN106039022A (zh) | 一种亮肤美白中药组合物、亮肤美白中药制剂、亮肤美白面膜、制备方法 | |
CN106902076A (zh) | 一种通用乳膏基质及其临方调剂 | |
CN105816663A (zh) | 一种具有营养抗衰作用的中药组合物、面霜及其制备方法 | |
CN105380874A (zh) | 一种海藻面膜的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170630 |