CN106901326A - A kind of preparation and application of ganoderma lipsiense full agonist - Google Patents
A kind of preparation and application of ganoderma lipsiense full agonist Download PDFInfo
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- CN106901326A CN106901326A CN201710151877.4A CN201710151877A CN106901326A CN 106901326 A CN106901326 A CN 106901326A CN 201710151877 A CN201710151877 A CN 201710151877A CN 106901326 A CN106901326 A CN 106901326A
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- ganoderma lipsiense
- ganoderma
- lipsiense
- full agonist
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Abstract
The invention discloses a kind of preparation and application of ganoderma lipsiense full agonist, it is with ganoderma lipsiense as raw material, step by step arithmetic is carried out using polarity ethanol solution from small to large and water after being crushed, digested through compound protease again, the alcohol extract of ganoderma lipsiense 85% 95%, ganoderma lipsiense 55% 65% alcohol extract, ganoderma lipsiense water extract and zymolyte are respectively obtained, that is, obtains ganoderma lipsiense full agonist." monarch " theory and modern nutrition theory according to the traditional Chinese medical science, the integration of drinking and medicinal herbs active component that one or more in the ganoderma lipsiense full agonist have identical effect with other is compounded, to prepare nutrient functional foods the effects such as with strengthen immunity, regulation blood sugar, blood fat, blood pressure and liver protection.
Description
Technical field
The invention belongs to active skull cap components separation technology field, and in particular to a kind of system of ganoderma lipsiense full agonist
It is standby with application.
Background technology
Ganoderma lipsiense is a kind of fungi for eating medicine dual-purpose, and basidiomycetes Asia mouth, Hymenomycetes, non-skirt are under the jurisdiction of on classification of fungi
Zoopagales, Ganodermataceae, Ganoderma.Ganoderma lipsiense is rich in multiple nutritional components, such as polysaccharide, steroidal compounds, triterpene, lipid, amino
Acid, polypeptide, protein-based, alkaloids, phenols, lactone, Coumarins and glucoside and trace element etc., prepare and both had
There is ganoderma lipsiense peculiar taste, and suppress growth of cancer cells with enhancing immune function of human body dispelling fatigue liver protectings, carry
Sleep quality high, expelling intestinal toxin, beauty, nourishing and fit keeping function and analgesic, heat-clearing, change product, hemostasis, resolving sputum, the health-care efficacy calmed the nerves and
The product of nutritive value, therefore with good DEVELOPMENT PROSPECT.
But at present in the technology for efficiently preparing ganoderma lipsiense active component, often there is the preparation of ganoderma lipsiense active material
Not exclusively, manufacture craft is cumbersome, the low problem of utilization rate.For these problems, serial solvent is used the invention provides one kind
（Polarity is from small to large）Extraction prepares the method for ganoderma lipsiense active material, and has not yet to see such report, and the method pair
Promoting ganoderma lipsiense large-scale industrial production has good DEVELOPMENT PROSPECT.
At present in the Patents of disclosed ganoderma lipsiense full agonist, the preparation for Ganoderma applanatum polysaccharide has
" a kind of ganoderma applanatum polysaccharide oral liquid and preparation method thereof "（CN 103735562A）.And serial solvent is used in the present invention（Pole
Property is from small to large）The method that extraction prepares ganoderma lipsiense active material, with will not occur side reaction, mild condition, environment friend
Good the advantages of, and gained active material has functions that good hypoglycemic, blood fat, blood pressure.
The content of the invention
It is an object of the invention to provide a kind of preparation and application of ganoderma lipsiense full agonist, it can solve to deposit at present
Active material prepare not exclusively, the low problem of utilization rate, to promote ganoderma lipsiense product large-scale industrial production have
Good application prospect.
To achieve the above object, the present invention is adopted the following technical scheme that：
A kind of preparation method of ganoderma lipsiense full agonist, it is, with ganoderma lipsiense as raw material, polarity to be used after being crushed
Ethanol solution and water from small to large carries out step by step arithmetic, then is digested through compound protease, respectively obtains ganoderma lipsiense 85%-95%
Alcohol extract, ganoderma lipsiense 55%-65% alcohol extracts, ganoderma lipsiense water extract and zymolyte, that is, obtain the full active matter of ganoderma lipsiense
Matter；
Its preparation method comprises the following steps：
1）Ganoderma lipsiense fructification pulverizer is worn into fine powder standby；
2）With 85wt%-95wt% ethanol solutions it is solvent by gained ganoderma lipsiense fine powder, ultrasound-microwave cooperating at 45-70 DEG C
Extraction or ultrasound assisted extraction 0.5-3h, filtering obtain ganoderma lipsiense 85%-95% alcohol extracts；
3）By step 2）Remaining filter residue is solvent with 55wt%-65wt% ethanol solutions, ultrasound-microwave cooperating at 45-70 DEG C
Extraction or ultrasound assisted extraction 0.5-3h, filtering obtain ganoderma lipsiense 55%-65% alcohol extracts；
4）Again by step 3）Remaining filter residue deionized water is solvent, the microwave and ultrasonic wave synergic extraction or super at 70-100 DEG C
Sound assisted extraction 0.5-3h, filtering obtains ganoderma lipsiense Aqueous extracts；
5）Finally by step 4）Water extraction residue under the conditions of 37-65 DEG C, with the compound protease of ganoderma lucidum fine powder weight 0.2-2%
Enzymolysis 0.5-3h, then filters, to obtain ganoderma lipsiense zymolyte；
6）By step 2）~5）Products therefrom is obtained ganoderma lipsiense 85%-95% alcohol extracts, artist's conk respectively after concentrated under reduced pressure, dry
Ganoderma lucidum 55%-65% alcohol extracts, ganoderma lipsiense water extract and zymolyte.
Step 2）~4）Extraction process in solvent and material ratio be 1:10-1:50 g/mL.
According to the traditional Chinese medical science " monarch " theory and modern nutrition theory, by present invention gained ganoderma lucidum full agonist
One or more and with identical effect integration of drinking and medicinal herbs active component compounding, with prepare have regulation blood sugar, blood fat, blood pressure
And the nutrient functional foods of the different dosage forms such as oral liquid, capsule, tablet, electuary, the solid beverage the effects such as liver protection.
The present invention is advantageous in that：
The present invention with ganoderma lipsiense as raw material, using serial solvent（Polarity is from small to large）Extract, finally use water extraction residue
The methods such as compound protease enzymolysis prepare ganoderma lipsiense full agonist." monarch " theory and modern nutrition according to the traditional Chinese medical science
Theory, can by it is therein one or more with other have identical effect integration of drinking and medicinal herbs active component compounding prepare product
Can have enrich blood, pre- preventing obesity, hypotensive, hypoglycemic, reducing blood lipid, liver protection, resist cardiovascular and cerebrovascular disease, improve body immunity
The effects such as.And present invention process is reliable and stable, repeatability is high, practical, is suitable for large-scale industrial production.
Specific embodiment
In order that content of the present invention easily facilitates understanding, with reference to specific embodiment to of the present invention
Technical scheme is described further, but the present invention is not limited only to this.
Embodiment 1
1）Ganoderma lipsiense fructification pulverizer is worn into fine powder standby；
2）By solid-liquid ratio 1:Gained ganoderma lipsiense fine powder is solvent with 85wt% ethanol solutions by 50 kg/L, ultrasonic at 70 DEG C-
Microwave synergistic extraction 0.5h, filtering obtains the alcohol extract of ganoderma lipsiense 85%；
3）By solid-liquid ratio 1:50 kg/L are by step 2）Remaining filter residue is solvent with 55wt% ethanol solutions, ultrasonic at 70 DEG C-
Microwave synergistic extraction 0.5h, filtering obtains the alcohol extract of ganoderma lipsiense 55%；
4）By solid-liquid ratio 1:50 kg/L are by step 3）Remaining filter residue deionized water is solvent, ultrasound-microwave at 100 DEG C
Synergic solvent extraction 0.5h, filtering obtains ganoderma lipsiense Aqueous extracts；
5）Finally by step 4）Water extraction residue is digested under the conditions of 65 DEG C with the compound protease of ganoderma lucidum fine powder weight 0.2%
0.5h, then filters, to obtain ganoderma lipsiense zymolyte；
6）By step 2）~5）Products therefrom is obtained the alcohol extract of ganoderma lipsiense 85%, ganoderma lipsiense respectively after concentrated under reduced pressure, dry
55% alcohol extract, ganoderma lipsiense water extract and zymolyte；
7）The alcohol extract of gained ganoderma lipsiense 85%, the alcohol extract of ganoderma lipsiense 55%, ganoderma lipsiense water extract and zymolyte are filled
Divide mixing, capsule is filled after drying, ganoderma lipsiense health-caring capsule is obtained.
Embodiment 2
1）Ganoderma lipsiense fructification pulverizer is worn into fine powder standby；
2）By solid-liquid ratio 1:Gained ganoderma lipsiense fine powder is solvent with 90wt% ethanol solutions by 30 kg/L, ultrasonic at 60 DEG C-
Microwave synergistic extraction 1h, filtering obtains the alcohol extract of ganoderma lipsiense 90%；
3）By solid-liquid ratio 1:30 kg/L are by step 2）Remaining filter residue is solvent with 60wt% ethanol solutions, ultrasonic at 50 DEG C-
Microwave synergistic extraction 1h, filtering obtains the alcohol extract of ganoderma lipsiense 60%；
4）By solid-liquid ratio 1:30 kg/L are by step 3）Remaining filter residue deionized water is solvent, and ultrasonic wave added is carried at 70 DEG C
3h is taken, is filtered, obtain ganoderma lipsiense Aqueous extracts；
5）Finally by step 4）Water extraction residue digests 5h under the conditions of 37 DEG C with the compound protease of ganoderma lucidum fine powder weight 2%,
Then filter, to obtain ganoderma lipsiense zymolyte；
6）By step 2）~5）Products therefrom is obtained the alcohol extract of ganoderma lipsiense 90%, ganoderma lipsiense respectively after concentrated under reduced pressure, dry
60% alcohol extract, ganoderma lipsiense water extract and zymolyte；
7）The alcohol extract of gained ganoderma lipsiense 90%, the alcohol extract of ganoderma lipsiense 60%, ganoderma lipsiense water extract and zymolyte are filled
Divide mixing, capsule is filled after drying, ganoderma lipsiense health-caring capsule is obtained.
Embodiment 3
1）Ganoderma lipsiense fructification pulverizer is worn into fine powder standby；
2）By solid-liquid ratio 1:Gained ganoderma lipsiense fine powder is solvent with 95wt% ethanol solutions by 10 kg/L, and ultrasound is auxiliary at 45 DEG C
Extraction 3h is helped, filtering obtains the alcohol extract of ganoderma lipsiense 95%；
3）By solid-liquid ratio 1:10 kg/L are by step 2）Remaining filter residue is solvent with 65wt% ethanol solutions, and ultrasound is auxiliary at 45 DEG C
Extraction 3h is helped, filtering obtains the alcohol extract of ganoderma lipsiense 65%；
4）By the alcohol extract of gained ganoderma lipsiense 95%, the alcohol extract of ganoderma lipsiense 65% and lily water extract, matrimony vine water extract by weight
Amount compares 1:2:1:0.5 is sufficiently mixed, and capsule is filled after drying, and ganoderma lipsiense health-caring capsule is obtained.
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with
Modification, should all belong to covering scope of the invention.
Claims (5)
1. a kind of preparation of ganoderma lipsiense full agonist, it is characterised in that：With ganoderma lipsiense as raw material, used after being crushed
Polarity ethanol solution from small to large and water carry out step by step arithmetic, then are digested through compound protease, respectively obtain ganoderma lipsiense
85%-95% alcohol extracts, ganoderma lipsiense 55%-65% alcohol extracts, ganoderma lipsiense water extract and zymolyte, that is, obtain ganoderma lipsiense complete
Active material.
2. according to claims 1 ganoderma lipsiense full agonist preparation, it is characterised in that：Comprise the following steps：
1）Ganoderma lipsiense fructification pulverizer is worn into fine powder standby；
2）With 85wt%-95wt% ethanol solutions it is solvent by gained ganoderma lipsiense fine powder, ultrasound-microwave cooperating at 45-70 DEG C
Extraction or ultrasound assisted extraction 0.5-3h, filtering obtain ganoderma lipsiense 85%-95% alcohol extracts；
3）By step 2）Remaining filter residue is solvent with 55wt%-65wt% ethanol solutions, ultrasound-microwave cooperating at 45-70 DEG C
Extraction or ultrasound assisted extraction 0.5-3h, filtering obtain ganoderma lipsiense 55%-65% alcohol extracts；
4）Again by step 3）Remaining filter residue deionized water is solvent, the microwave and ultrasonic wave synergic extraction or super at 70-100 DEG C
Sound assisted extraction 0.5-3h, filtering obtains ganoderma lipsiense Aqueous extracts；
5）Finally by step 4）Water extraction residue digests 0.5-3h under the conditions of 37-65 DEG C with compound protease, then filters, with
Obtain ganoderma lipsiense zymolyte；
6）By step 2）~5）Products therefrom is obtained ganoderma lipsiense 85%-95% alcohol extracts, tree respectively after concentrated under reduced pressure, dry
Tongue ganoderma lucidum 55%-65% alcohol extracts, ganoderma lipsiense water extract and zymolyte.
3. according to claims 2 ganoderma lipsiense full agonist preparation, it is characterised in that：Solvent in extraction process
It is 1 with the ratio of material:10-1:50 g/mL.
4. according to claims 2 ganoderma lipsiense full agonist preparation, it is characterised in that：Step 5）Middle compound protein
The addition of enzyme is the 0.1-2% of ganoderma lipsiense fine powder weight.
5. the application of ganoderma lipsiense full agonist prepared by a kind of method as claimed in claim 1, it is characterised in that：By institute
One or more in ganoderma lucidum full agonist and the integration of drinking and medicinal herbs active component compounding with identical effect, to prepare nutrition
Functional food.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107669711A (en) * | 2017-11-23 | 2018-02-09 | 广东省微生物研究所 | The preparation method and its usage of Ganoderma applanatum (Pers. Ex Wallr) Pat. extract |
| CN109200069A (en) * | 2018-10-08 | 2019-01-15 | 浙江理工大学 | Ganoderma lipsiense ethanol extract and application thereof |
| CN113788902A (en) * | 2021-10-22 | 2021-12-14 | 哈药集团技术中心 | Preparation method and application of Ganoderma applanatum polysaccharide extract |
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| CN1191116A (en) * | 1997-02-19 | 1998-08-26 | 方晓阳 | Oral snake liquid |
| CN1559305A (en) * | 2004-02-20 | 2005-01-05 | 付茂康 | Glossy ganoderma beverage, and its prepn. method |
| CN100998614A (en) * | 2006-12-31 | 2007-07-18 | 李晔 | Method for extracting spore powder of glossy ganoderma and deep processing technique for the product |
| CN101530436A (en) * | 2009-04-20 | 2009-09-16 | 浙江省林业科学研究院 | Method of effectively extracting ganoderma triterpenoids and ganoderan from mythic fungus germ entity |
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2017
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136931A (en) * | 1995-06-01 | 1996-12-04 | 聂聪忠 | Ant ginseng oral liquid and preparing process thereof |
| CN1191116A (en) * | 1997-02-19 | 1998-08-26 | 方晓阳 | Oral snake liquid |
| CN1559305A (en) * | 2004-02-20 | 2005-01-05 | 付茂康 | Glossy ganoderma beverage, and its prepn. method |
| CN100998614A (en) * | 2006-12-31 | 2007-07-18 | 李晔 | Method for extracting spore powder of glossy ganoderma and deep processing technique for the product |
| CN101530436A (en) * | 2009-04-20 | 2009-09-16 | 浙江省林业科学研究院 | Method of effectively extracting ganoderma triterpenoids and ganoderan from mythic fungus germ entity |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107669711A (en) * | 2017-11-23 | 2018-02-09 | 广东省微生物研究所 | The preparation method and its usage of Ganoderma applanatum (Pers. Ex Wallr) Pat. extract |
| CN109200069A (en) * | 2018-10-08 | 2019-01-15 | 浙江理工大学 | Ganoderma lipsiense ethanol extract and application thereof |
| CN113788902A (en) * | 2021-10-22 | 2021-12-14 | 哈药集团技术中心 | Preparation method and application of Ganoderma applanatum polysaccharide extract |
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