CN106889076B - Disease-resistant composition pesticide containing pheno second mycin and Tebuconazole and its application - Google Patents
Disease-resistant composition pesticide containing pheno second mycin and Tebuconazole and its application Download PDFInfo
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- CN106889076B CN106889076B CN201710143438.9A CN201710143438A CN106889076B CN 106889076 B CN106889076 B CN 106889076B CN 201710143438 A CN201710143438 A CN 201710143438A CN 106889076 B CN106889076 B CN 106889076B
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- tebuconazole
- mycin
- pheno
- composition pesticide
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition of second containing pheno mycin and Tebuconazole, the weight ratio of active constituent is 1 in the bactericidal composition:20‑15:1, the composition has preferable synergistic effect in the ratio range after compounding to powdery mildew of cucumber, in addition, the composition to crop safety, is worth promoting and applying in production.
Description
Technical field
The present invention relates to a kind of disease-resistant composition pesticides with synergistic effect, show extremely strong resistant effect,
Applied to crop disease control, it is mainly used for preventing the diseases such as fruit tree, vegetables, wheat, rice.
Background technology
Pheno second mycin, chemical name are N, N- diethyl azophenlyene -1- formamides, are that one kind is passed through by rape pseudomonad
Ferment the biological bactericide being prepared.CN201310309701.9 discloses the preparation method of pheno second mycin, and discloses institute
State biological bactericide to the various vegetables such as damping off of colza, cucumber downy mildew and powdery mildew and cereal crops disease fungus have compared with
Strong inhibiting effect.
Tebuconazole is a kind of triazole bactericidal agent of high-efficiency broad spectrum, to the multiple diseases on the crops such as cereal, fruit tree, vegetables
With interior suction, protection, treatment and eradicant action, the fungal diseases such as gray mold, powdery mildew, scab, sclerotiniose are all had very
Good control effect.But Tebuconazole belongs to ergosterol biosynthesis inhibitor, the series bactericidal agent action site is single, disease
Opportunistic pathogen is easy to generate medicament the variation of adaptability, declines so as to cause the control effect of medicament.
The use of either pheno second mycin or Tebuconazole, long-term continuous high dose can cause the residual of medicament, environment dirty
The problems such as dye and drug-resistant fungi develop.Rational chemical bactericide combination or mixture, which has, expands fungicidal spectrum, improves anti-
The generation for controlling effect, extending the optimum period for applying fertilizer, reducing dosage, reduce poisoning, reduce residual, delaying drug resistance of fungi
With development etc. positive feature, bactericide compounded or mixture be one of the most effective methods to solve the above problems.Develop new product
Fungicide price is constantly soaring, and in contrast, exploitation has investment with efficient, low toxicity, the compounding of low-residual and mixture is studied
Less, the lead time is short and paid attention to both at home and abroad, increases developing efforts one after another.Present inventor passes through a large amount of room
Interior virulence test and field control effectiveness test, are found surprisingly that after compounding pheno second mycin and Tebuconazole in a certain range to more
The prevention of kind pathogen of crop shows apparent synergistic function, completes the present invention after further research.And mesh
The preceding above-mentioned relevant report about the two compounding.
Invention content
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to which providing one kind containing pheno second mycin and Tebuconazole double activated
The bactericidal composition of ingredient, the two are had obvious synergistic function in a certain range by reasonably compounding, can be with
The generation for significantly improving the control effect of corps diseases, expanding fungicidal spectrum, delaying pathogen drug resistance.
Another object of the present invention is to provide the application of the bactericidal composition, the bactericidal composition is widely used in
House fruit, vegetables, watermelon, the multiple diseases on wheat are particularly suitable for prevention powdery mildew etc..
The bactericidal composition with synergistic effect of the present invention adopts the following technical scheme that realization：
A kind of bactericidal composition, at least contains two kinds of active components, wherein the first active constituent is pheno second mycin, second
Active constituent is Tebuconazole, wherein the weight ratio of pheno second mycin and Tebuconazole is 1:20-15：1.
Preferably, the weight ratio of the pheno second mycin and Tebuconazole is preferably 1:10-5：1.
Preferably, the weight percentage of composition shared by active constituent is 1-90% in the bactericidal composition, preferably
5-50%。
Preferably, bactericidal composition of the invention further includes contributing to the conventional auxiliary that active constituent is stablized and drug effect plays
Ingredient, and be all to commonly use in Pesticide formulation or the various composition used, the auxiliary element is allowed to include auxiliary agent and/or load
Body, wherein at least one are surfactants, and the auxiliary agent can be disintegrant, antifreeze, antifoaming agent, thickener etc., described
Surfactant can be dispersant or wetting agent.
Preferably, bactericidal composition of the invention is prepared into the arbitrary of suitable agricultural use by being aided with conventional auxiliary element
A kind of dosage form, selected from wettable powder, water dispersible granules, aqueous emulsion, microemulsion, suspending agent, microcapsule suspending agent.
Further, composition of the invention can be provided each substance in i.e. composition in the form of finished product preparation and mixed
It closes, can also be provided with unit dose form, directly be mixed, be then diluted to required dense in proportion in bucket or tank using preceding
Degree.
Further, bactericidal composition of the invention can spray use, and can also dress seed or soak seed use, usage amount
Cause harm degree and Disease Resistance degree with weather condition, crop condition variation, disease and changes.
Further, bactericidal composition of the invention can also contain other agricultural active ingredients.
Compared with prior art, the advantageous effect of bactericidal composition of the invention includes at least following several points：
1, bactericidal composition of the invention is by reasonably compounding in a certain range to the anti-jig of farming also disease
There is apparent synergistic function, control effect can be improved；
2, the active constituent mechanism of action is different in bactericidal composition of the invention, and the two compounding can increase to cause of disease
The action site of bacterium, can to avoid and/or delay the generation of pathogen drug resistance；
3, bactericidal composition dosage of the invention is lower with respect to single dose, it is possible to reduce pesticide activity component usage amount, drop
Low drug cost reduces pollution of the Pesticide use to environment.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, present invention following specific examples
It illustrates, but the present invention is limited to absolutely not these examples.It is as described below to be only the preferred embodiment of the present invention, it is used only for explaining
The present invention, but cannot be therefore understands that for the limitation to the scope of the claims of the present invention.It should be pointed out that it is all the present invention spirit and
Any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention made by within principle, therefore,
The protection domain of patent of the present invention should be determined by the appended claims.
One, example of formulations
1, embodiment 1:28.6% pheno second mycin Tebuconazole wettable powder（1:10）
Pheno second mycin 2.6%
Tebuconazole 26%
Neopelex 4%
Sodium lignin sulfonate 3%
Dispersant NNO 3%
White carbon 10%
Diatomite surplus
The preparation method of the wettable powder is：By above-mentioned formula by pesticide activity component and dispersant, wetting agent
It is mixed with filler, stirs evenly, be uniformly mixed after being smashed by air jet mill in a stirring kettle, you can be made of the present invention
Wettable powder.
2, embodiment 2:3.6% pheno second mycin tebuconazole suspension concentrates（1：1）
Pheno second mycin 1.8%
Tebuconazole 1.8%
Sodium lignin sulfonate 6%
Dispersant MF -5 2%
Xanthans 2%
Organic silicone 1.4%
Ethylene glycol 3%
Deionized water surplus
The preparation method of the suspending agent is：By above-mentioned formula by deionized water, wetting agent, dispersant, thickener, freeze proof
Agent, antifoaming agent are uniformly mixed, and are uniformly mixed through high speed shear, and pheno second mycin and Tebuconazole is added, and it is uniformly equal to continue shear-mixed
It is even, it is then added in horizontal sand mill and grinds, make preparation grain size at 5 microns hereinafter, can be prepared by suspension of the present invention
Agent.
3, embodiment 3:10.8% pheno second mycin Tebuconazole missible oil（7:5）
Pheno second mycin 6.3%
Tebuconazole 4.5%
Methyl oleate 8%
N-Methyl pyrrolidone 10%
Fatty alcohol polyoxyethylene ether 6%
Calcium dodecyl benzene sulfonate 3%
Soybean oil surplus
The preparation method of the missible oil is：By the formula by pheno second mycin, Tebuconazole, solvent, cosolvent in reaction kettle
In be uniformly mixed, then stabilizer, emulsifier are added in reaction kettle and continues to mix, stir evenly, you can institute of the present invention is made
The missible oil stated.
4, embodiment 4:18% pheno second mycin tebuconazole water dispersible granule（5：1）
Pheno second mycin 15%
Tebuconazole 3%
Dialkyl group Succinate sodium sulfonate salt 5%
Lignosulfonates 4%
Ammonium sulfate 3%
Arabic gum 4%
Diatomite surplus
The preparation method of the water dispersible granules is：By above-mentioned formula by pheno second mycin, Tebuconazole, dispersant, wetting agent,
Disintegrant, filler obtain required grain size through air-flow crushing together, add binder, obtain granulation materials.Item is quantified
It is sent into fluidized bed granulating dryer after granulation and drying, you can water dispersible granules of the present invention are made.
Two, toxicity measures
Subjects：Cucumber powdery mildew's pathogen
Test method：Experiment refers to People's Republic of China (PRC) professional standard NY/T 1156.11-2008《Pesticide indoor biological
Measure the 11st part of test rule fungicide：It prevents cucurbits powdery mildew and tests pot-culture method》, measured using pot-culture method.
Susceptible cucumber variety is sowed, it is spare that potting grows to 2 leaf periods.Pheno second mycin and Tebuconazole mother liquor are used respectively
0.1% Tween-80 aqueous surfactant solution solvent.3 basins are often handled, 10 mL liquids are uniformly sprayed on blade face extremely by 4 repetitions
All wettings, wait for that liquid naturally dry is spare.And it sets containing only solvent and surfactant and makees without containing the processing for imitating ingredient empty
White control.24 h after chemicals treatment, spray inoculation cucumber powdery mildew's pathogen spore suspension.The process for preparation of spore suspension is such as
Under：It takes and covers with Powdery Mildew blade, washed down spore with the sterile water for a small amount of Tween-80 surfactant that refuels, double gauze
It filters, 1 × 10 is modulated into after microscopy5The suspension of a/mL.Inoculation is placed in thermostatic chamber, and 7 are cultivated under the conditions of 24 DEG C of temperature
It.When blank control disease liquid rate reaches 80% or more, incidence is managed in classification investigation everywhere, calculates the disease index of each processing
And control effect.
Control effect is converted into probit value（y）, liquor strength（ug/mL）It is converted into logarithm（x）, by minimum in terms of multiplication
Concentration EC in calculating virulence equation and inhibiting50, the toxicity index and co-toxicity coefficient of medicament are calculated according to Sun Yunpei's Method（CTC）.Experiment knot
Fruit is shown in Table 1.
As shown in Table 1, the prevention of powdery mildew of cucumber is showed in a certain range after pheno second mycin and Tebuconazole compounding
Go out synergistic function, wherein when the two compound proportion is 1:10-5:When 1, co-toxicity coefficient is all higher than 150 or more, synergy
Effect becomes apparent from, and shows that the two compounding is relatively reasonable within the scope of aforementioned proportion.
Three, field control effectiveness test
In order to further verify the practical application effect of the present invention, prevention cucumber is carried out using the medicament of the embodiment of the present invention
Powdery mildew field control effectiveness test.
Reagent agent：（1）28.6% pheno second mycin Tebuconazole wettable powder（1:10）；（2）3.6% pheno second mycin penta
Azoles alcohol suspending agent（1：1）；（3）10.8% pheno second mycin Tebuconazole missible oil（7:5）；（4）18% pheno second mycin Tebuconazole moisture
Shot agent（5：1）；（5）Comparative example 1:1% pheno second mycin suspending agent；（6）Comparative example 2:12.5% tebuconazole suspension concentrates.
It 5 days after medicine, investigates within 10 days disease indexs and calculates preventive effect, test result is shown in Table 2.
Field control effectiveness test result shows that microbicide compositions of the invention show preferably the prevention of powdery mildew of cucumber
Lasting effect and quick-acting, the bactericidal composition containing pheno second mycin and Tebuconazole effective ingredient consumption be 20 g/ hectares when,
5,10 days control effects to powdery mildew of cucumber are 70% or more after medicine, hence it is evident that due to the comparison medicament of single active constituent.This
Outside, during experiment, cucumber crop safety, no poisoning occur for reagent agent, do not observe and are generated not to other beneficial organisms
Good influence shows that the composition pesticide of the present invention is worth promoting and applying in production.
Claims (7)
1. a kind of composition pesticide, which is characterized in that active constituent include pheno second mycin and Tebuconazole, wherein pheno second mycin and
The weight ratio of Tebuconazole is 1:20-15：1.
2. composition pesticide according to claim 1, which is characterized in that the weight ratio of the pheno second mycin and Tebuconazole is excellent
It is selected as 1:10-5：1.
3. composition pesticide according to claim 1, which is characterized in that the weight ratio of the pheno second mycin and Tebuconazole is excellent
It is selected as 7:5.
4. according to the composition pesticide described in any one of claim 1-3 claims, which is characterized in that the composition is auxiliary
It is processed into any one dosage form with the auxiliary element in Pesticide formulation.
5. composition pesticide according to claim 4, which is characterized in that the composition pesticide dosage form is wettable powder
Agent, water dispersible granules, missible oil, aqueous emulsion, microemulsion, suspending agent, microcapsule suspending agent.
6. the composition pesticide according to any one of claim 1-5 claims is used to prevent the purposes of corps diseases.
7. purposes according to claim 6, which is characterized in that the corps diseases are powdery mildew.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710143438.9A CN106889076B (en) | 2017-03-11 | 2017-03-11 | Disease-resistant composition pesticide containing pheno second mycin and Tebuconazole and its application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710143438.9A CN106889076B (en) | 2017-03-11 | 2017-03-11 | Disease-resistant composition pesticide containing pheno second mycin and Tebuconazole and its application |
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| Publication Number | Publication Date |
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| CN106889076A CN106889076A (en) | 2017-06-27 |
| CN106889076B true CN106889076B (en) | 2018-09-21 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103329907A (en) * | 2013-07-22 | 2013-10-02 | 上海农乐生物制品股份有限公司 | Preparation method for fenethazine mycin biochemical germicide |
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- 2017-03-11 CN CN201710143438.9A patent/CN106889076B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103329907A (en) * | 2013-07-22 | 2013-10-02 | 上海农乐生物制品股份有限公司 | Preparation method for fenethazine mycin biochemical germicide |
Non-Patent Citations (1)
| Title |
|---|
| 7种杀菌剂防治黄瓜白粉病田间药效评价;宋益民等;《现代农药》;20160630;第15卷(第3期);第48-50页 * |
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| TR01 | Transfer of patent right |
Effective date of registration: 20190923 Address after: Room 208 and 209, Building C, High-tech Venture Service Center, Tongling City, Anhui Province Patentee after: TONGLING AMCO NEW MATERIAL TECHNOLOGY Co.,Ltd. Address before: 528000, room 1613, 2, 6 South Fenjiang Road, Chancheng District, Guangdong, Foshan, two Patentee before: FOSHAN RUISHENGTONG TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20211201 Address after: 262500 No. 3077 Yadong street, Weifang Economic Development Zone, Shandong Province Patentee after: SHANDONG BAINONGSIDA BIOTECHNOLOGY CO.,LTD. Address before: Room 208 and 209, building C, Tongling high tech entrepreneurship service center, Anhui 244000 Patentee before: TONGLING AMCO NEW MATERIAL TECHNOLOGY Co.,Ltd. |
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Denomination of invention: Anti-resistant pesticide composition containing phenethylmycin and tebuconazole and its application Effective date of registration: 20230110 Granted publication date: 20180921 Pledgee: Weifang Bank Co.,Ltd. Qingzhou Qicheng sub branch Pledgor: SHANDONG BAINONGSIDA BIOTECHNOLOGY CO.,LTD. Registration number: Y2023980030792 |
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