CN106880418A - Devices and methods therefor for studying the effect of pressure therapy hyperplastic scar and mechanism - Google Patents
Devices and methods therefor for studying the effect of pressure therapy hyperplastic scar and mechanism Download PDFInfo
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- CN106880418A CN106880418A CN201710102047.2A CN201710102047A CN106880418A CN 106880418 A CN106880418 A CN 106880418A CN 201710102047 A CN201710102047 A CN 201710102047A CN 106880418 A CN106880418 A CN 106880418A
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- 231100000241 scar Toxicity 0.000 title claims abstract description 91
- 206010020718 hyperplasia Diseases 0.000 title claims abstract description 31
- 230000002390 hyperplastic effect Effects 0.000 title claims abstract description 26
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 21
- 230000000694 effects Effects 0.000 title claims abstract description 18
- 230000007246 mechanism Effects 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title description 5
- 230000002146 bilateral effect Effects 0.000 claims abstract description 18
- 238000002474 experimental method Methods 0.000 claims description 16
- 210000001774 pressoreceptor Anatomy 0.000 claims description 8
- 240000007711 Peperomia pellucida Species 0.000 claims description 7
- 230000010534 mechanism of action Effects 0.000 claims description 6
- 208000032544 Cicatrix Diseases 0.000 claims description 5
- 230000035755 proliferation Effects 0.000 claims description 5
- 230000037387 scars Effects 0.000 claims description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 4
- 230000001969 hypertrophic effect Effects 0.000 claims description 4
- 230000000452 restraining effect Effects 0.000 claims description 4
- 230000001629 suppression Effects 0.000 claims description 4
- 238000005259 measurement Methods 0.000 claims description 3
- 208000027418 Wounds and injury Diseases 0.000 abstract description 5
- 230000006378 damage Effects 0.000 abstract description 4
- 238000013461 design Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 229920003023 plastic Polymers 0.000 abstract description 3
- 239000004033 plastic Substances 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 8
- 238000010171 animal model Methods 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000002775 capsule Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 229920000965 Duroplast Polymers 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 241000025414 Pentalagus furnessi Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000008407 joint function Effects 0.000 description 1
- -1 laser therapy Substances 0.000 description 1
- 238000002647 laser therapy Methods 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Surgery (AREA)
- Instructional Devices (AREA)
Abstract
The invention discloses a kind of device for studying the effect of pressure therapy hyperplastic scar and mechanism, including 2 jig arm, screw, nut, bilateral scar presss from both sides jig arm connecting groove and spring leaf, 2 jig arm tops press from both sides jig arm connecting groove and connect by bilateral scar, 2 jig arm top correspondence positions offer circular notch, 2 jig arm bottoms are circular pressure plate, spring leaf is provided between 2 jig arm, screw is passed through from the notch of side, opposite side lock screw of the nut in notch, simple structure, scar clip main body structure is overall press mold, jointless design avoids applying stressed secondary injury, in addition, material is elastic metallic or plastics, have no toxic side effect, it is safe and reliable.
Description
Technical field
The present invention relates to experimental animal model field, and in particular to one kind is for studying the effect of pressure therapy hyperplastic scar
And the devices and methods therefor of mechanism.
Background technology
Hyperplastic scar is the abnormal final result of healing after wound, not only influences patient's outward appearance appearance, and its contracture for producing can
Cause different degrees of joint function disturbance, while patients ' life quality is reduced, heavy economy and the heart is brought to patient
Reason burden.The method of clinical conventional treatment hyperplastic scar includes at present：Surgery excision, external used medicine, laser therapy, medicine
Injection and radiotherapy etc., curative effect is not good enough and spends higher.Pressure therapy is used as a kind of non-damage for preventing and treating hyperplastic scar
Physical therapy modalities, be widely used in clinic.However, the curative effect that pressure acts on hyperplastic scar is all based on clinical sight
Examine and experience, due to lacking suitable experimental animal model, the optimum pressure power size and pressure of clinical practice pressure therapy are definite
Mechanism of action it is still unintelligible so far so that the pressure therapy of hyperplastic scar lacks scientific and systematicness.
The content of the invention
It is to solve above-mentioned deficiency that the purpose of the present invention is, there is provided one kind for study the effect of pressure therapy hyperplastic scar and
The device of mechanism.
The purpose of the present invention is achieved through the following technical solutions：
A kind of device for studying the effect of pressure therapy hyperplastic scar and mechanism, including 2 jig arm, screw, nut, bilaterals
Scar presss from both sides jig arm connecting groove and spring leaf, and 2 jig arm tops press from both sides jig arm connecting groove and connect by bilateral scar, 2 jig arm
Top correspondence position offers circular notch, and 2 jig arm bottoms are circular pressure plate, spring is provided between 2 jig arm
Piece, screw is passed through from the notch of side, opposite side lock screw of the nut in notch.
Pressure plate is internally provided with slipmat and pressoreceptor chip, and pressoreceptor chip is arranged under slipmat
Portion.
The distance between 2 jig arm are 2-15mm.
Slipmat circle of position shape, string is made.
A kind of experimental technique for studying the effect of pressure therapy hyperplastic scar and mechanism, step is as follows：
S1, structure rabbits hypertrophic scars model, the scar of rabbit ear is gone out to be placed in the space in scar folder bilateral jig arm, first
Screw is placed in the draw-in groove of scar clip main body, then by nut from opposite side rotation be fixed on screw, by set screw,
The position of nut and elasticity adjust nip pressure size；
When S2, measurement scar clamping force, Flexfore pressure sensing measuring systems are connected to scar folder increased pressure board internal pressure
On receptor chip, pressure clamp pressure applied is shown by corresponding computer software system in real time, and according to requirement of experiment
Correct and adjust pressure value size；
It is the hyperplasia degree of scar, such as height of projection, color, hard by observing in the case where different pressures are acted on after S3, experiment terminate
Degree etc. determines the actuating pressure of most suitable suppression scar proliferation；Additionally, by follow-up histology and biological study, it is right
The definite mechanism of action that pressure restraining hyperplastic scar is formed is explored and studied.
The present invention has following beneficial effect：
1. with strong points, i.e., the process of hyperplastic scar is treated using animal model simulation clinical pressure, it is research pressure therapy
Mechanism of action provides basis；
2. scar pressure therapy folder pressure applied size is adjustable, controllable and detectable, i.e., adjust pressure by screw and nut
Power size, slipmat and spring leaf maintain pressure constant, and pressoreceptor chip can external Flexfore pressure capsule systems, reality
When detect pressure size；
3. simple structure, scar clip main body structure is overall press mold, and jointless design avoids applying stressed secondary injury,
Additionally, material is elastic metallic or plastics, have no toxic side effect, it is safe and reliable；
4. easy to use, the size of press member and the spacing of bilateral jig arm have various different models, it is adaptable to different size of
Scar.
Brief description of the drawings
Fig. 1 is installation diagram of the invention；
Fig. 2 is installation diagram of the invention two；
Fig. 3 is installation diagram of the invention three；
Fig. 4 is that scar of the invention presss from both sides coronal-plane schematic diagram；
Fig. 5 is that scar of the invention presss from both sides sagittal plane schematic diagram；
Fig. 6 be in scar of the invention folder screw and nut fix, joining place enlarged drawing；
Fig. 7 is jig arm coronal-plane schematic diagram in left side of the invention；
Fig. 8 is jig arm coronal-plane schematic diagram in right side of the invention；
Fig. 9 is pressure plate internal structure schematic diagram of the invention；
Figure 10 is experimental procedure of the invention；
Figure 11 is experimental procedure of the invention two；
Figure 12 is experimental procedure of the invention three；
Figure 13 is experimental procedure of the invention four；
Figure 14 is pressue-graph of the invention.
Specific embodiment
The present invention is further illustrated below in conjunction with the accompanying drawings：
As shown in Fig. 1-Fig. 9, a kind of device for studying the effect of pressure therapy hyperplastic scar and mechanism, including 2 jig arm,
Screw 2, nut 3,5,2 jig arm tops of bilateral scar folder jig arm connecting groove 4 and spring leaf press from both sides jig arm and connect by bilateral scar
Connect groove 4 to connect, 2 jig arm top correspondence positions offer circular notch, 2 jig arm bottoms are circular pressure plate 1,2
Spring leaf 5 is provided between individual jig arm, screw 2 is passed through from the notch of side, opposite side lock screw of the nut 3 in notch.
Pressure plate is internally provided with slipmat 6 and pressoreceptor chip 7, and pressoreceptor chip is arranged under slipmat
Portion.
The distance between 2 jig arm are 2-15mm.
Slipmat circle of position shape, string is made.
A kind of experimental technique for studying the effect of pressure therapy hyperplastic scar and mechanism, step is as follows：
S1, structure rabbits hypertrophic scars model, the scar of rabbit ear is gone out to be placed in the space in scar folder bilateral jig arm, first
Screw is placed in the draw-in groove of scar clip main body, then by nut from opposite side rotation be fixed on screw, by set screw,
The position of nut and elasticity adjust nip pressure size；
When S2, measurement scar clamping force, Flexfore pressure sensing measuring systems are connected to scar folder increased pressure board internal pressure
On receptor chip, pressure clamp pressure applied is shown by corresponding computer software system in real time, and according to requirement of experiment
Correct and adjust pressure value size；
It is the hyperplasia degree of scar, such as height of projection, color, hard by observing in the case where different pressures are acted on after S3, experiment terminate
Degree etc. determines the actuating pressure of most suitable suppression scar proliferation；Additionally, by follow-up histology and biological study, it is right
The definite mechanism of action that pressure restraining hyperplastic scar is formed is explored and studied.
Scar pressure therapy folder includes：A. skin and scar are clamped and stressed symmetry jig arm is applied：Material is metal
Or duroplasts, lower end circular portion is for attaching skin and applies stressed part, a diameter of 8-15mm, for different size of wound
Face scar；B. pressoreceptor chip：Positioned at jig arm lower end pressure-producing part inner face, for experiencing, monitoring and scar folder is transmitted
Real-time pressure；C. slipmat：It is sponge positioned at the jig arm lower end pressure-producing part back side, is used to the position for maintaining scar to press from both sides
Put, prevent from shifting and slip；D. spring leaf：Between bilateral jig arm, for the pressure for maintaining scar to press from both sides；E. screw and spiral shell
It is female：Have a circular notch positioned at jig arm upper end, screw passes through the notch from one section, nut from other end fixed screw, by rotation
Turn nut adjusts the pressure between bilateral jig arm；F. jig arm connecting groove：While connection bilateral jig arm, the design of its groove can
Increase bilateral jig arm mobile range, scar is pressed from both sides the cicatricial tissue for being applicable to different-thickness.So that in upper-part, symmetry is pressed from both sides
The connecting groove of arm and upper end is formed by a single piece of metal sheet or rigid plastics entirety press mold, is the integrated connection without interface, is kept away
It is 2-15mm to exempt from the distance between junction void damage skin, bilateral symmetric property jig arm, it is adaptable to different size of rabbit ear scar
Model.
The animal model of pressure therapy hyperplastic scar：A. rabbit ear full thickness dermal model, medical 3M films are set up
Tegderm is covered, every other day more change dressings, 14 days wound healings after wound, and visible scar proliferation；B. scar is folded in hyperplasia
In scar, scar clamping force is adjusted by rotating nut, Flexfore pressure capsule systems are connected to clip inside pressure sense
By on chip, real-time monitoring scar folder applies stressed size.
Rabbit ear veutro full thickness skin cuts off model construction；After rabbit ear wound healing, cicatrization, what scar was pressed from both sides fixing and controlling
Treat；Flexfore pressure sensings measuring system is measured to the pressure that scar is pressed from both sides；Computer real-time monitoring simultaneously shows that scar is clamped
Power, needs to adjust pressure size according to experiment；Scar clamping force is measured and corrected in different time points, pressure is drawn out
Curve, display scar folder can for a long time keep the pressure value of stabilization.
Test method：S1. rabbits hypertrophic scars model is built, the scar of rabbit ear is gone out to be placed in scar folder bilateral jig arm
Space in, screw is placed in the draw-in groove of scar clip main body first, then by nut from opposite side rotation be fixed on screw,
Nip pressure size is adjusted by set screw, the position of nut and elasticity；
When S2. measuring scar clamping force, Flexfore pressure sensing measuring systems are connected to scar folder increased pressure board internal pressure
On receptor chip, pressure clamp pressure applied is shown by corresponding computer software system in real time, and according to requirement of experiment
Correct and adjust pressure value size；
S3. it is the hyperplasia degree of scar, such as height of projection, color, hard by observing in the case where different pressures are acted on after experiment terminates
Degree etc. determines the actuating pressure of most suitable suppression scar proliferation；Additionally, by follow-up histology and biological study, it is right
The definite mechanism of action that pressure restraining hyperplastic scar is formed is explored and studied.Above experimental data, is clinical practice pressure
Power treatment hyperplastic scar provides reliable scientific basis.
Claims (5)
1. it is used to study the device of the effect of pressure therapy hyperplastic scar and mechanism, including 2 jig arm, screw, nut, bilateral scars
Trace presss from both sides jig arm connecting groove and spring leaf, it is characterised in that：2 jig arm tops press from both sides jig arm connecting groove and connect by bilateral scar
Connect, 2 jig arm top correspondence positions offer circular notch, and 2 jig arm bottoms are circular pressure plate, between 2 jig arm
Spring leaf is provided with, screw is passed through from the notch of side, opposite side lock screw of the nut in notch.
2. the device for studying the effect of pressure therapy hyperplastic scar and mechanism according to claim 1, its feature exists
In：Described pressure plate is internally provided with slipmat and pressoreceptor chip, and pressoreceptor chip is arranged under slipmat
Portion.
3. the device for studying the effect of pressure therapy hyperplastic scar and mechanism according to claim 1, its feature exists
In：The distance between 2 described jig arm are 2-15mm.
4. the device for studying the effect of pressure therapy hyperplastic scar and mechanism according to claim 2, its feature exists
In：Described slipmat circle of position shape, string is made.
5. it is used to study the experimental technique of the effect of pressure therapy hyperplastic scar and mechanism, it is characterised in that：Step is as follows：
S1, structure rabbits hypertrophic scars model, the scar of rabbit ear is gone out to be placed in the space in scar folder bilateral jig arm, first
Screw is placed in the draw-in groove of scar clip main body, then by nut from opposite side rotation be fixed on screw, by set screw,
The position of nut and elasticity adjust nip pressure size；
When S2, measurement scar clamping force, Flexfore pressure sensing measuring systems are connected to scar folder increased pressure board internal pressure
On receptor chip, pressure clamp pressure applied is shown by corresponding computer software system in real time, and according to requirement of experiment
Correct and adjust pressure value size；
It is the hyperplasia degree of scar, such as height of projection, color, hard by observing in the case where different pressures are acted on after S3, experiment terminate
Degree etc. determines the actuating pressure of most suitable suppression scar proliferation；Additionally, by follow-up histology and biological study, it is right
The definite mechanism of action that pressure restraining hyperplastic scar is formed is explored and studied.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710102047.2A CN106880418A (en) | 2017-02-24 | 2017-02-24 | Devices and methods therefor for studying the effect of pressure therapy hyperplastic scar and mechanism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710102047.2A CN106880418A (en) | 2017-02-24 | 2017-02-24 | Devices and methods therefor for studying the effect of pressure therapy hyperplastic scar and mechanism |
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| Publication Number | Publication Date |
|---|---|
| CN106880418A true CN106880418A (en) | 2017-06-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710102047.2A Pending CN106880418A (en) | 2017-02-24 | 2017-02-24 | Devices and methods therefor for studying the effect of pressure therapy hyperplastic scar and mechanism |
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| CN (1) | CN106880418A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110292473A (en) * | 2019-07-01 | 2019-10-01 | 吉林大学 | A kind of ear scar pressure clamp |
| CN114680077A (en) * | 2022-01-13 | 2022-07-01 | 中山大学附属第一医院 | Method for preparing rat model for inhibiting hypertrophic scar by mechanical pressure |
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| WO2008080164A2 (en) * | 2006-12-22 | 2008-07-03 | Sevrain Lionel C | Anchoring device for posteriorly attaching adjacent verterbrae |
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| CN103370032A (en) * | 2010-12-23 | 2013-10-23 | R&M咨询贸易有限责任两合公司 | (Partial) device for preventing incontinence having a fastening apparatus for stationary implantation in body tissue |
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| CN104840241A (en) * | 2015-06-10 | 2015-08-19 | 哈尔滨邦美医疗科技有限公司 | Micro external fixator with two dynamically-adjustable arms |
| CN204909812U (en) * | 2015-09-02 | 2015-12-30 | 孙云云 | Eye specialist is with tearing bag tweezers |
| CN204951055U (en) * | 2015-08-26 | 2016-01-13 | 牛海玲 | Hemostatic clamp |
-
2017
- 2017-02-24 CN CN201710102047.2A patent/CN106880418A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1681465A (en) * | 2002-09-09 | 2005-10-12 | 发美利株式会社 | Massaging device and forearm massaging machine |
| CN1872005A (en) * | 2006-06-29 | 2006-12-06 | 张磊 | Clamp for curing scar |
| WO2008080164A2 (en) * | 2006-12-22 | 2008-07-03 | Sevrain Lionel C | Anchoring device for posteriorly attaching adjacent verterbrae |
| WO2011134035A1 (en) * | 2010-04-29 | 2011-11-03 | Adalberto De Carvalho Vale | Ergonomic tool for atraumatic tooth extraction |
| CN201977857U (en) * | 2010-10-21 | 2011-09-21 | 平荧 | Cicatrix therapeutic splint system device |
| CN103370032A (en) * | 2010-12-23 | 2013-10-23 | R&M咨询贸易有限责任两合公司 | (Partial) device for preventing incontinence having a fastening apparatus for stationary implantation in body tissue |
| CN203291371U (en) * | 2013-04-10 | 2013-11-20 | 平荧 | Adjustable clip-shaped external skin expander |
| CN103989536A (en) * | 2014-04-24 | 2014-08-20 | 中国人民解放军第四军医大学 | Precision mouse spinal cord clamping injury clamp and clamping injury force adjusting method |
| CN104840241A (en) * | 2015-06-10 | 2015-08-19 | 哈尔滨邦美医疗科技有限公司 | Micro external fixator with two dynamically-adjustable arms |
| CN204951055U (en) * | 2015-08-26 | 2016-01-13 | 牛海玲 | Hemostatic clamp |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110292473A (en) * | 2019-07-01 | 2019-10-01 | 吉林大学 | A kind of ear scar pressure clamp |
| CN114680077A (en) * | 2022-01-13 | 2022-07-01 | 中山大学附属第一医院 | Method for preparing rat model for inhibiting hypertrophic scar by mechanical pressure |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170623 |
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| RJ01 | Rejection of invention patent application after publication |