CN106861040A - A kind of brain damage reparation and the method and apparatus of reconstruction - Google Patents
A kind of brain damage reparation and the method and apparatus of reconstruction Download PDFInfo
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- CN106861040A CN106861040A CN201710084119.5A CN201710084119A CN106861040A CN 106861040 A CN106861040 A CN 106861040A CN 201710084119 A CN201710084119 A CN 201710084119A CN 106861040 A CN106861040 A CN 106861040A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
Abstract
The method and apparatus that the embodiment of the present invention provides a kind of brain damage reparation and reconstruction,It is related to medical field,It is used to provide one kind by activating proliferation of endogenous neural stem cells,Differentiation damages brain area dead cell and sets up iuntercellular function connects to substitute,It is final to promote to damage brain area reparation and reconstruction,Damage brain area including determining acceptor,Stimulating electrode is positioned over the first predeterminated position,Reference electrode is positioned over the second predeterminated position,By the parameter for setting regulation brain damage prosthetic appliance,With control device to damage brain area stimulus modality and stimulus intensity,The embodiment of the present invention is based on cranial nerve control technique principle,The characteristics of there is multi-lineage potential and the of self-replication capacity using stem cell,Using safety,Noninvasive electrical transcranial stimulation mode,Activation proliferation of endogenous neural stem cells,Differentiation damages brain area dead cell and sets up iuntercellular function connects to substitute,It is possible to prevente effectively from exogenous stem cells treat the various drawbacks of brain damage.
Description
Technical field
The present embodiments relate to medical field, more particularly to a kind of brain damage reparation and reconstruction method and set
It is standby.
Background technology
Brain damage refers to that violence acts on head and causes the organic damage of brain tissue.Brain damage is with its high rate, wound high
Human health in the characteristics of residual rate, high mortality and serious harm, and causes serious commercial burden to society and family.
At this stage on brain damage generally using suit the medicine to the illness supportive treatment and the functional rehabilitation of chronic phase for being confined to acute stage
Treatment, its essence is that the brain tissue/cell for having damaged there is no to avoid the protectiveness based on secondary brain insults from treating
Effect treatment method.With continuing to develop for regenerative medicine, stem cells technology brings dawn for brain damage reparation.At present, external source
Property stem cell transplantation technology due to there are problems that in actual applications immunological rejection, transplanting after survival rate it is low, limit
Its clinical practice.Autologous nerve stem cell (Neural Stem Cell, NSCs) though transplanting with survival rate higher, it is autologous
The extraction of NSCs is invasive, can aggravate brain damage or even directly result in death.
The content of the invention
The method and apparatus that embodiments of the invention provide a kind of brain damage reparation and reconstruction, be used to using safety,
Noninvasive electrical transcranial stimulation mode, activates proliferation of endogenous neural stem cells, differentiation to substitute damage zone dead cell and set up
Iuntercellular function connects, it is final to promote to damage brain area reparation and reconstruction.
To reach above-mentioned purpose, embodiments of the invention are adopted the following technical scheme that：
In a first aspect, the equipment that the embodiment of the present invention provides a kind of brain damage reparation and reconstruction, including：It is serially connected
Power supply unit, stimulation instrument and stereotaxic apparatus, wherein, power supply unit, for providing operating voltage to stimulation instrument；Stimulate
Instrument, for receiving selection signal, and according to selection signal, determines the selected stimulating current of selection signal, and vertical to brain
Body position indicator exports the first control signal, and the first control signal includes the parameter of the selected stimulating current of selection signal, and
Stimulation time corresponding with stimulating current；Stereotaxic apparatus, is additionally operable under the triggering of the first control signal, electric according to stimulating
Corresponding stimulation time is flowed, stimulating current is implemented to the damage brain area of acceptor by stimulating electrode, the damage brain area of acceptor is behaved
Class patient damages brain area correspondence scalp surface or the corresponding skull surface of damage brain area for the animal class patient.
With reference in a first aspect, in the first possible implementation of first aspect, above-mentioned operating voltage is 8V-10V.
With reference to the first possible implementation of first aspect or first aspect, second in first aspect is possible
In implementation, stereotaxic apparatus is brain electricity cap, and brain electricity cap includes elasticated net, multiple electricity have been arranged in parallel on elasticated net
Cartridge, sub- damage field different in the different corresponding brain areas by bulk damage of electrode tip, multiple electrodes head in multiple electrodes head
In each electrode tip there is accommodating chamber, accommodating chamber bottom is fixed with foam-rubber cushion, each electrode tip include first end and the second end, one
The first end of individual electrode tip is used for fixed electrode film, and electrode slice is used to be connected with stimulation instrument, and the second end is used to be fixed on elasticated net
On, stimulating electrode for stereotaxic apparatus work when, any one electrode tip for being connected with stimulation instrument in multiple electrodes head.
With reference to any one possible implementation in second possible implementation of first aspect to first aspect,
In the third possible implementation of first aspect, stimulation instrument includes：The power management module being connected with power supply unit, with
The connected adjustment module of power management module and electrode contact monitoring modular, and the display module that is connected with adjustment module and
D/A converter module, and the constant current source module being connected with D/A converter module, electrode contact monitoring modular also with display module
It is connected, wherein, power management module, for operating voltage to be converted into adjustment module, electrode contact monitoring modular, display respectively
Module and D/A converter module distinguish corresponding rated operational voltage；Adjustment module, for receiving selection signal, and according to choosing
Select signal and the selected stimulus modality of selection signal is determined from default stimulus modality mapping table, and according to selected stimulation
The corresponding goal stimulus electric current of pattern exports goal stimulus electric current to D/A converter module, and for sending the to display module
Two control signals, second control signal be used for indicate the display module display target stimulating current and with goal stimulus electric current
Corresponding stimulation time, default stimulus modality mapping table includes at least one stimulus modality, and a stimulus modality includes one
The corresponding relation of stimulating current and stimulation time；Electrode contact monitoring modular, for detecting that stimulating electrode connects with position is stimulated
Produced impedance value when touching；Display module, for the working condition and display target thorn of show electrode contact monitoring modular
Swash electric current and stimulation time corresponding with goal stimulus electric current；D/A converter module, for the target for exporting adjustment module
Stimulating current is converted to analog current from digital current, and exports to constant-current source mould goal stimulus electric current according to analog current
Block；Constant current source module, for exporting the first control signal to stereotaxic apparatus.
With reference to any one in the third possible implementation of first aspect to first aspect, the of first aspect
In four kinds of possible implementations, default stimulus modality mapping table includes：Stimulus of direct current pattern, impulse stimulation pattern, sine
Stimulus modality and pseudo- stimulus modality, wherein, the adjustable frequency scope of sinusoidal stimulus modality is：0.01-250HZ, impulse stimulation
The adjustable pulse cycle 100-2000ms of pattern, the adjustable pulse width scope of impulse wave is 100-2000ms.
With reference to any one in the 4th kind of possible implementation of first aspect to first aspect, the of first aspect
In five kinds of possible implementations, stimulation instrument also includes：Detection module, control module and alarm module；Wherein, detection module
Size and stimulation time for detecting stimulating current；Control module, for stimulating current be more than predetermined current threshold when,
To alarm module output control signal；Alarm module, for sending alarm according to control signal；Control module, with power management
Module is connected, and is additionally operable to when stimulation time reaches preset time threshold, and control power management module is off.
In another possible design, the adjustment module in the stimulation instrument of the embodiment of the present invention is realized based on FPGA.
Second aspect, the embodiment of the present invention provides a kind of method that brain damage is repaired, and the method is applied to first aspect extremely
Brain damage prosthetic appliance in 5th kind of possible implementation of first aspect described by any one possible implementation,
The method includes：Determine the damage brain area of acceptor, the damage brain area has at least one in following characteristics：Bleeding, ischemic, water
Paradoxical discharge when swollen, contusion, axonal injury and electroencephalogram；Stimulating electrode is positioned over the first predeterminated position, wherein, if
Acceptor is the human patientses with brain damage, then the first predeterminated position is that human patientses damage brain area correspondence scalp surface, if receiving
Body is animal class patient, then the first predeterminated position is the corresponding skull surface of damage brain area of animal class patient, and stimulating electrode is used
In to the corresponding damage brain area implementation stimulating current of stimulating electrode；Reference electrode is positioned over the second predeterminated position, wherein, second
Predeterminated position is any one position in addition to brain area is damaged on acceptor, generally damages area on the brain hemisphere offside eye socket of side；
The regulation parameter of brain damage prosthetic appliance is set, and to determine the selected stimulus modality of the regulation parameter, stimulus modality includes
Stimulating current and stimulation time corresponding with the stimulating current；According to the corresponding stimulation time of stimulating current, by stimulating electricity
Implement stimulating current to the acceptor in pole.
With reference to second aspect, in the first possible implementation of second aspect, acceptor is the people with brain damage
Class patient, accordingly, determines the damage brain area of acceptor, including：According to nuclear magnetic resonance, CT iconographies, electroencephalogram, electrophysiologic study
Result determines to damage brain area.
With reference to the first possible implementation of second aspect or second aspect, second in second aspect is possible
In implementation, stimulating current more than 0min is less than or equal to more than 0mA and less than or equal to 2mA, and stimulation time
30min。
With reference to any one in second possible implementation of second aspect to second aspect, the of second aspect
In three kinds of possible implementations, before stimulating electrode is positioned over into the first predeterminated position, method provided in an embodiment of the present invention
Also include：Stereotaxic apparatus is worn on the brain of the human patientses with brain damage；By in the brain region of human patientses
Damage brain area be defined as the first predeterminated position.
With reference to any one in the third possible implementation of second aspect to second aspect, the of second aspect
In four kinds of possible implementations, acceptor is the animal class patient with brain damage, and accordingly, stimulating current is more than 0uA and small
In or equal to 500uA, stimulation time is more than 0min less than or equal to 30min.
It is understood that if acceptor is the human patientses with brain damage, second predeterminated position is electric to stimulate
On the offside brain area socket of the eye of pole, if the acceptor is the animal class patient with brain damage, second predeterminated position is with brain
The thorax abdomen of the animal class patient of damage.
Brief description of the drawings
Fig. 1 is a kind of structural representation one of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 2 is a kind of structural representation two of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 3 is a kind of structural representation three of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 4 a are a kind of structural representation four of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 4 b are a kind of structural representation five of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 5 is a kind of structural representation six of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 6 is a kind of structural representation seven of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 7 is a kind of structural representation eight of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 8 is a kind of schematic flow sheet of brain damage prosthetic appliance provided in an embodiment of the present invention；
Fig. 9 is a kind of structural representation nine of brain damage prosthetic appliance provided in an embodiment of the present invention；
Figure 10 is a kind of structural representation ten of brain damage prosthetic appliance provided in an embodiment of the present invention.
Specific embodiment
As shown in figure 1, a kind of brain damage prosthetic appliance is the embodiment of the invention provides, including：Power supply unit 10, with power supply
The stimulation instrument 11 of the connection of part 10 and the stereotaxic apparatus 12 being connected with stimulation instrument.Wherein, power supply unit 10, for thorn
Swash instrument 11 and operating voltage is provided, stereotaxic apparatus 12, for stimulating electrode to be positioned over into the first predeterminated position, and by reference
Electrode is positioned over the second predeterminated position, wherein, if acceptor is the human patientses with brain damage, the first predeterminated position is stimulation
Electrode site, if acceptor is the animal class patient with brain damage, the first predeterminated position is the damage brain area of animal class patient
Corresponding skull surface；Second predeterminated position is any one position in addition to brain area is damaged on acceptor；Stimulation instrument 11, is used for
Selection signal is received, and according to selection signal, determines the selected stimulating current of selection signal, and to stereotaxic apparatus
Export the first control signal, the parameter of first control signal including the selected stimulating current of selection signal, and with stimulation
The corresponding stimulation time of electric current, stereotaxic apparatus is additionally operable under the triggering of the first control signal, according to stimulating current correspondence
Stimulation time, stimulating current is implemented to the damage brain area of acceptor by stimulating electrode, the damage brain area of acceptor is human patientses
Damage brain area correspondence scalp surface or the corresponding skull surface of damage brain area for animal class patient.
It is understood that type and stimulating current of the parameter of embodiment of the present invention moderate stimulation electric current for stimulating current
Intensity, the type of stimulating current is it can be appreciated that in the stimulus modality of stimulating current.
A kind of brain damage reparation provided in an embodiment of the present invention and the method and apparatus of reconstruction, the equipment are based on brain god
Regulated know-why, the characteristics of there is multi-lineage potential and the of self-replication capacity using stem cell, by Naoliqing capsule
Stimulating electrode and reference electrode are individually positioned in corresponding position by instrument, for example, stimulating electrode is placed on the first predeterminated position, ginseng
Be placed on the second predeterminated position according to electrode, then by stimulation instrument to stereotaxic apparatus export selected stimulating current and with
The corresponding stimulation time of stimulating current, so, using safety, noninvasive electrical transcranial stimulation mode, activation endogenous neural stem is thin
Born of the same parents' propagation, differentiation are final to promote brain damage reparation and reconstruction to substitute damaging cells and set up iuntercellular function connects.Should
It is possible to prevente effectively from external cause treats the various drawbacks of brain damage, such as conventional effect of controlling is poor, exogenous stem cells transplantation treatment for mode
The problems such as immunological rejection, tumorigenesis, ethics are limited, while evaded the secondary damage of transplantation treatment after endogenous retinal stem cells are extracted,
Realize the regenerative medicine treatment with the characteristics of noninvasive.
Optionally, the operating voltage that power supply unit 10 is provided for stimulation instrument in the embodiment of the present invention less than or equal to 10V, greatly
In or equal to 5V.Exemplary, the operating voltage is 9V.
Optionally, as shown in Fig. 2 Fig. 2 shows a kind of stereotaxic apparatus provided in an embodiment of the present invention, for example, brain
Electric cap.
Specifically, as shown in figure 3, brain electricity cap includes elasticated net 120, multiple electricity have been arranged in parallel on elasticated net 120
Cartridge 121, the different subregions of the corresponding acceptor brain region of different electrode tips 121 in multiple electrodes first 121.
It is understood that the brain region of human patientses includes many sub-regions, the correspondence One function per sub-regions,
For example, being illustrated so that the brain region of human patientses includes subregion A, subregion B and subregion C as an example, art technology
Personnel should be understood that in real process the brain region of human patientses includes subregion A, subregion B and subregion C
Many sub-regions above, the embodiment of the present invention is illustrated by taking subregion A, subregion B and subregion C as an example, not
Constitute the limitation of the embodiment of the present invention.
It is understood that between multiple electrodes first 121 in the embodiment of the present invention by the first conductor in parallel together.
As shown in fig. 4 a, each electrode tip 121 has accommodating chamber 123 in multiple electrodes first 121 in the embodiment of the present invention, holds
Receiving the bottom of chamber 123 is fixed with foam-rubber cushion 124, and each electrode tip includes first end and the second end, and a first end for electrode tip is used
In wire 126 is connected with fixed electrode film 125, electrode slice 125, the wire 126 is used to connect stimulation instrument 11, and the second end is used for
Be fixed on elasticated net, stimulating electrode for stereotaxic apparatus work when, multiple electrodes head in be connected with stimulation instrument it is any one
Individual electrode tip.
Exemplary, for example, subregion A correspondence extremity motor functions, subregion B correspondence linguistic functions, subregion C correspondences
Writing function.Also, electrode tip is respectively disposed with subregion A and subregion B, subregion C, if the corresponding functions of subregion A
Need to rebuild, namely subregion A to damage brain area, then in actual use, the electrode tip that will be arranged on subregion A leads to
Cross wire to be connected with the output end of stimulation instrument, be arranged so as to the electrode tip on subregion A and can be used as stimulating electrode to sub-district
Domain A implements electrode stimulating.
Optionally, the embodiment of the present invention is not defined to the concrete shape of each electrode tip, as long as each electrode tip
Exemplary in hollow shape, the electrode tip can be in hollow round table-like, the present invention of hollow cylindrical as shown in fig. 4 a
Embodiment is not defined to this, can be configured as needed in actual use.
The first end of any one electrode tip or can be detachably connected with electrode slice clamping in the embodiment of the present invention
(for example, being connected by double buckle) or other modes are connected, and as shown in Figure 4 b, the embodiment of the present invention is not defined to this,
As long as enabling to electrode tip can collect the stimulating current that stimulation instrument is exported by electrode slice.
Specifically, in order to reduce impedance, the accommodating chamber 123 in the embodiment of the present invention is used to accommodate physiological saline, so will
Physiological saline is placed in after accommodating chamber 123, and physiological saline can moisten the damage brain area that the electrode tip is contacted by foam-rubber cushion,
So as to the impedance for reducing stimulating electrode He be stimulated position.
As shown in figure 5, stimulation instrument 11 includes：The power management module 111 being connected with power supply unit 10, with power management mould
The connected adjustment module 112 of block 111 and electrode contact monitoring modular 116, and the display module being connected with adjustment module 112
113 and D/A converter module (D/A modular converters) 114, and the constant current source module 115 being connected with D/A converter module 114, electricity
Pole contact monitoring modular 116 is also connected with display module 113.
Wherein, power management module 111, for exporting operating voltage respectively to adjustment module, electrode contact monitoring mould
Block, display module and D/A converter module.
It is understood that the power management module 111 in the embodiment of the present invention includes voltage drop element and boosting unit
Part, wherein, voltage drop element is used to become 9V operating voltages the target voltage turned to less than 9V operating voltages, for example, power management
Voltage drop element in module 111 is exported to display module 113 specifically for the change of 9V operating voltages is turned into 5V, by 9V operating voltages
Change turns to 3.3V and exports to D/A modular converters.
Boosting element is used to become 9V operating voltages the target voltage turned to higher than 9V operating voltages, for example, 9V is worked
Voltage is converted to the voltage output of 30V to constant current source module 115 by the boosting element in power management module 111.
Adjustment module 112 is for receiving selection signal and true from default stimulus modality mapping table according to selection signal
The fixed selected stimulus modality of selection signal, and according to the corresponding goal stimulus electric current of selected stimulus modality to number
Mould modular converter exports the goal stimulus electric current, and for sending the second control signal to the display module, and described the
Two control signals are used to indicate the display module display target stimulating current and stimulation time corresponding with goal stimulus electric current,
The default stimulus modality mapping table includes at least one stimulus modality, and a stimulus modality includes a stimulating current
With the corresponding relation of stimulation time.
Optionally, the adjustment module 112 in the embodiment of the present invention also includes regulation parameter selecting module 1121, regulation ginseng
Number selecting module 1121 is used to select stimulus modality, and for setting the corresponding stimulation parameter of the stimulus modality.
As shown in fig. 6, the regulation parameter selecting module 1121 includes stimulus of direct current selecting module, impulse stimulation selection mould
Block, sinusoidal stimulation selecting module and pseudo- stimulation selecting module, wherein, stimulus of direct current selecting module is used to indicate selected thorn
Energizing mode is stimulus of direct current pattern, and impulse stimulation selecting module is used to indicate selected stimulus modality for impulse stimulation pattern,
It is sinusoidal stimulus modality for indicating selected stimulus modality that sine stimulates selecting module, and puppet stimulates selecting module for indicating
Selected stimulus modality is pseudo- stimulus modality.
It is understood that any one module input trigger signal in regulation parameter selecting module 1121
Afterwards, then the adjustment module 112 determines to receive trigger signal, and a stimulating current regulation window is shown on the stimulation instrument
Mouthful, for indicating selection target stimulating current, the stimulating current that certain goal stimulus electric current can be directly inputted for user is big
Small, such as 2A now, that is, represents that adjustment module receives selection signal, or adjustment module 112 determines to receive triggering
After signal, a direct shown initial impulse electric current in stimulating current regulation window, for example, as shown in fig. 7, figure
7 illustrate by taking user's selection stimulus of direct current pattern as an example：When the stimulus modality selected by user is stimulus of direct current pattern in Fig. 7,
The initial impulse electric current 2A for then being shown in stimulating current regulation window, user can be by adjusting electric current increasing button
And current value reduces button and the initial impulse electric current is increased or reduced, for example, initial impulse current value is increased
1.5A is reduced to 2.5A or by initial impulse current value.It is understood that after initial impulse current value is conditioned, after
It is displayed in stimulating current regulation window, the current value increasing button is often triggered once, and the initial impulse current value increases by the
One predetermined threshold value, and current value reduces button and is often triggered once, and the initial impulse current value reduces by the second predetermined threshold value, this
Inventive embodiments are not defined to the first predetermined threshold value and the second predetermined threshold value, wherein, the first predetermined threshold value and second is preset
Threshold value can with it is equal can also be unequal, the embodiment of the present invention is not defined to this, can be set as needed.
On the other hand, the regulation parameter selecting module in the embodiment of the present invention includes at least one regulation button, at least one
Each regulation button one stimulus modality of correspondence in individual regulation button, the corresponding regulation button of stimulus modality is used to adjust
The regulation parameter (for example, stimulating current value) of the stimulus modality.It is understood that there is a scale on each regulation button
Disk, each scale one current value of correspondence on dial.
For example, at least one regulation button can include the first regulation button, the second regulation button, the 3rd regulation is pressed
Button, and the 4th regulation button, wherein, the first regulation button is corresponding with stimulus of direct current pattern, and the second regulation button is pierced with pulse
Energizing mode correspondence, the 3rd regulation button is corresponding with sinusoidal stimulus modality, and the 4th stimulus modality is corresponding with pseudo- stimulus modality.
It is understood that in actual use, if user's regulation first adjusts button, it is determined that selected by user
Stimulus modality be stimulus of direct current pattern, user regulation second adjust button, it is determined that the selected stimulus modality of user be arteries and veins
Spurt energizing mode, by that analogy, the embodiment of the present invention is not defined to this.
It is understood that each stimulus modality can correspond at least one stimulating current in the embodiment of the present invention, at least
One stimulation time of each stimulating current correspondence in one stimulating current.
Specifically, the stimulation instrument also has memory in implementation process, the memory is used to store default stimulus modality
Mapping table, the default stimulus modality mapping table can use form as shown in table 1：
Table 1 presets stimulus modality mapping table
It should be understood that when user adjusts button by regulation first, you can think that it uses stimulus of direct current pattern to receiving
Body is implemented to stimulate, and so its selection signal being input into includes the first scale value, due to being deposited in default stimulus modality mapping table
There are the mapping relations between the first scale value and stimulating current 1 and stimulation time 1, therefore, it can according to the selection being input into
Signal is implemented to stimulate to acceptor according to stimulating current 1 and stimulation time 1.
Electrode contact monitoring modular 116, for impedance value produced when detecting stimulating electrode and being stimulated location contacts.
Display module 113, working condition and the display brain damage for show electrode contact monitoring modular 116 are repaiied
Stimulating current and stimulation time of the multiple equipment when implementing to stimulate；
Wherein, the working condition in the embodiment of the present invention includes normal operating conditions or abnormal operating state.
On the one hand, the working condition can be indicated by indicator lamp, if for example, electrode contact monitoring modular 116 is in
Then indicator lamp is shown in green for normal operating conditions, is indicated if electrode contact monitoring modular 117 is in abnormal operating state
Lamp is shown in red.Certainly, on the other hand, in display module if electrode contact monitoring modular 116 is in normal operating conditions
The printed words such as " normal " on 113, it is " non-on display module 113 if electrode contact monitoring modular 116 is in abnormal operating state
The printed words such as normally ".
D/A converter module 114, for the digital current that adjustment module 112 is exported to be converted into analog current, and presses
Goal stimulus electric current is exported to constant current source module 115 according to analog current.
Constant current source module 115, for exporting the first control signal to stereotaxic apparatus.
Optionally, presetting stimulus modality mapping table includes：Stimulus of direct current pattern, impulse stimulation pattern, sinusoidal stimulation mould
Formula and pseudo- stimulus modality；Wherein, the adjustable frequency scope of the sinusoidal stimulus modality is：0.01-250HZ, the pulse thorn
The adjustable pulse cycle 100-2000ms of energizing mode, the adjustable pulse width scope of the impulse wave is 100-2000ms.
Optionally, stimulation instrument 11 also includes：Detection module, control module and alarm module；Wherein, detection module is used for
Detect the size and the stimulation time of the stimulating current；
Control module, for when the stimulating current is more than predetermined current threshold, to the alarm module output control
Signal；
Alarm module, for sending alarm according to the control signal；
Control module, is connected with power management module, is additionally operable to when stimulation time reaches preset time threshold, control electricity
Source control module disconnects.
Preset time threshold is stimulation time corresponding with stimulating current in the embodiment of the present invention.
As shown in fig. 7, the embodiment of the present invention provides a kind of method that brain damage is repaired, the method is applied to above-described embodiment
In described brain damage prosthetic appliance, the method includes：
S101, the damage brain area for determining acceptor, the damage brain area have at least one in following characteristics：Bleeding, lack
Paradoxical discharge when blood, oedema, contusion, axonal injury and electroencephalogram；
Optionally, step S101 can be accomplished by the following way：
Determined to damage brain area according to nuclear magnetic resonance, CT iconographies and electroencephalogram electro physiology means.
S102, stimulating electrode is positioned over the first predeterminated position, wherein, if the acceptor is the mankind with brain damage suffering from
Person, then first predeterminated position is stimulation electrode sites, if the acceptor is animal class patient, first predeterminated position
It is the corresponding skull surface of damage brain area of the animal class patient, stimulating electrode is used for the corresponding damage of the stimulating electrode
Brain area implements stimulating current.
S103, reference electrode is positioned over the second predeterminated position, wherein, the second predeterminated position is except described on the acceptor
Any one position damaged outside brain area.
Exemplary, if acceptor is the human patientses with brain damage, the second predeterminated position is stimulating electrode offside brain
On area's socket of the eye, if acceptor is the animal class patient with brain damage, the second predeterminated position is the animal class patient with brain damage
Thorax abdomen.
S104, the regulation parameter for setting brain damage prosthetic appliance, to determine the selected stimulus modality of regulation parameter, stimulate
Pattern includes stimulating current and stimulation time corresponding with stimulating current.
S105, according to the corresponding stimulation time of stimulating current, stimulating current is implemented to acceptor by stimulating electrode.
Optionally, when acceptor is human patientses, stimulating current is more than 0mA and less than or equal to 2mA, and stimulation time
30min is less than or equal to more than 0min.
It is understood that stimulating current value is bigger, stimulation time value is smaller.
Optionally, when acceptor behaviour carrys out patient, before step S102, method provided in an embodiment of the present invention is also wrapped
Include：
S106, the brain that electrode cap is worn on the human patientses for having brain damage；
S107, the damage brain area in human patientses brain region is defined as the first predeterminated position.
Optionally, acceptor is the animal class patient with brain damage, accordingly, stimulating current more than 0uA and less than or wait
In 500uA, stimulation time is less than or equal to 30min more than 0min.
As shown in figure 9, Fig. 9 shows, brain damage reparation provided in an embodiment of the present invention and work(when acceptor is human patientses
The structural representation of the equipment that can be rebuild, the process of its specific brain damage reparation and reconstruction is：By stereotaxic apparatus
Human patientses head is worn on, to cause a part in each electrode tip correspondence brain region on stereotaxic apparatus
(for example, subregion), secondly, wire and Naoliqing capsule is passed through by the output end (i.e. the output end of constant current source module) of stimulation instrument
Electrode slice connection on any one electrode tip of instrument, then the electrode tip being connected with the output end of stimulation instrument is i.e. in Naoliqing capsule
Instrument when working as stimulating electrode, then by stereotaxic apparatus any one electrode tip and the second predeterminated position (for example,
Connection on stimulating electrode offside brain area socket of the eye, as shown in Figure 2), used as reference electrode, (wherein, the effect of reference electrode is to protect
Card stimulation circuit conducting, it is ensured that stimulating current is by damaging brain area), a stimulation is then selected by the adjustment module of stimulation instrument
(the goal stimulus electric current can be corresponding for selected stimulus modality for pattern goal stimulus electric current corresponding with the stimulus modality
Initial impulse current value can also be for adjusting/directly inputting after stimulating current value), then stimulation instrument is according to the target
Stimulating current is from the corresponding stimulation time of default stimulus modality mapping table selection target stimulating current (for example, thorn corresponding with 2A
The time of swashing is 5min), so selected goal stimulus electric current can be exported to stimulating electrode by wire, for Naoliqing capsule
Instrument implements electric shock stimulation by stimulating electrode to the corresponding brain area of damaging of the stimulating electrode.
As shown in Figure 10, Figure 10 shows, brain damage reparation provided in an embodiment of the present invention when acceptor is animal class patient
With the structural representation of the equipment of reconstruction, the process of its specific brain damage reparation and reconstruction is：Will thorn before stimulating
Sharp electrode is positioned over the impaired brain area correspondence skull surface of experimental animal, and reference electrode is positioned over experimental animal thorax abdomen, regulation thorn
Swash parameter and open stimulus modality and implement to stimulate.
Then a stimulus modality is selected with corresponding goal stimulus under the stimulus modality by the adjustment module of stimulation instrument
(the goal stimulus electric current can also be able to be for adjusting for the corresponding initial impulse current value of selected stimulus modality to electric current
Stimulating current value after saving/directly inputting), then stimulation instrument is selected according to the goal stimulus electric current from default stimulus modality mapping table
The corresponding stimulation time of goal stimulus electric current is selected (for example, rodent stimulating current upper safety limit is 500uA, stimulation time
The upper limit is 20min (remaining experimental animal needs clearly).So selected goal stimulus electric current can be exported to thorn by wire
Electrode is swashed, so that stereotaxic apparatus is stimulated by stimulating electrode to the corresponding brain area implementation electric shock of damaging of the stimulating electrode.
It is apparent to those skilled in the art that, for convenience and simplicity of description, only with above-mentioned each function
The division of module is carried out for example, in practical application, as needed can distribute by different function moulds above-mentioned functions
Block is completed, will the internal structure of device be divided into different functional modules, to complete all or part of work(described above
Energy.The specific work process of the system, apparatus, and unit of foregoing description, may be referred to corresponding in preceding method embodiment
Journey, will not be repeated here.
In several embodiments provided herein, it should be understood that disclosed system, apparatus and method can be with
Realize by another way.For example, device embodiment described above is only schematical, for example, the module or
The division of unit, only a kind of division of logic function, can there is other dividing mode when actually realizing, such as multiple units
Or component can be combined or be desirably integrated into another system, or some features can be ignored, or not perform.It is another, institute
Display or the coupling each other for discussing or direct-coupling or communication connection can be by some interfaces, device or unit
INDIRECT COUPLING or communication connection.
The unit that is illustrated as separating component can be or may not be it is physically separate, it is aobvious as unit
The part for showing can be or may not be physical location, you can with positioned at a place, or can also be distributed to multiple
On NE.Some or all of unit therein can be according to the actual needs selected to realize the mesh of this embodiment scheme
's.
In addition, during each functional unit in each embodiment of the invention can be integrated in a processing unit, it is also possible to
It is that unit is individually physically present, it is also possible to which two or more units are integrated in a unit.Above-mentioned integrated list
Unit can be realized in the form of SFU software functional unit.
If the integrated unit is to realize in the form of SFU software functional unit and as independent production marketing or use
When, can store in a computer read/write memory medium.Based on such understanding, all or part of the technical scheme
Can be embodied in the form of software product, the computer software product is stored in a storage medium, including some fingers
Order is used to so that a computer equipment (can be personal computer, server, or network equipment etc.) or computing device
The all or part of step of each embodiment methods described of the invention.The storage medium is non-transitory (English：non-
Transitory) medium, including：Flash memory, mobile hard disk, read-only storage, random access memory, magnetic disc or light
Disk etc. is various can be with the medium of store program codes.
The above, specific embodiment only of the invention, but protection scope of the present invention is not limited thereto, and it is any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all contain
Cover within protection scope of the present invention.Therefore, protection scope of the present invention described should be defined by scope of the claims.
Claims (10)
1. the equipment of a kind of brain damage reparation and reconstruction, it is characterised in that including：Power supply unit and the power supply unit
The stimulation instrument of connection and the stereotaxic apparatus being connected with the stimulation instrument；
Wherein, the power supply unit, for providing operating voltage to the stimulation instrument；
The stimulation instrument, for receiving selection signal, and according to the selection signal, determines that the selection signal is selected
Stimulating current, and the first control signal is exported to the stereotaxic apparatus, first control signal includes the selection
The parameter of the selected stimulating current of signal, and stimulation time corresponding with the stimulating current；
The stereotaxic apparatus, is additionally operable under the triggering of first control signal, corresponding according to the stimulating current
Stimulation time, the stimulating current is implemented by stimulating electrode to the damage brain area of acceptor, and the damage brain area of the acceptor is behaved
Class patient damages brain area correspondence scalp surface or the corresponding skull surface of damage brain area for the animal class patient.
2. equipment according to claim 1, it is characterised in that the stereotaxic apparatus is brain electricity cap, the brain electricity cap
Including elasticated net, multiple electrodes head is arranged in parallel on the elasticated net, different electrode tip pair in the multiple electrode tip
Different subregion in the brain region of the acceptor answered, each electrode tip has accommodating chamber in the multiple electrode tip, institute
State accommodating chamber bottom and be fixed with foam-rubber cushion, described each electrode tip includes first end and the second end, the of electrode tip
One end is used for fixed electrode film, and wire is connected with the electrode slice, and the wire on an electrode slice is used to be connected with stimulation instrument,
Second end is used to be fixed on the elasticated net, described many when the stimulating electrode is that the stereotaxic apparatus works
Any one electrode tip being connected with the stimulation instrument in individual electrode tip.
3. equipment according to claim 1, it is characterised in that the stimulation instrument includes：It is connected with the power supply unit
Power management module, the adjustment module being connected with the power management module and electrode contact monitoring modular, and with it is described
The display module and D/A converter module of adjustment module connection, and the constant current source module being connected with the D/A converter module,
The electrode contact monitoring modular is also connected with the display module,
Wherein, the power management module, for the operating voltage to be converted into the adjustment module respectively, the electrode connects
Monitoring modular is touched, the display module and the D/A converter module distinguish corresponding rated operational voltage；
The adjustment module, for receiving the selection signal, and maps according to the selection signal from default stimulus modality
Determine the selected stimulus modality of the selection signal in table, and according to the corresponding target thorn of the selected stimulus modality
Swash electric current and export the goal stimulus electric current to the D/A converter module, and controlled for sending second to the display module
Signal processed, second control signal is used to indicate the display module to show the goal stimulus electric current and pierced with the target
Swash the corresponding stimulation time of electric current, the default stimulus modality mapping table includes at least one stimulus modality, a thorn
Energizing mode includes the corresponding relation of a stimulating current and stimulation time；
The electrode contact monitoring modular, for impedance produced when detecting the stimulating electrode and being stimulated location contacts
Value；
The display module, for showing the working condition of the electrode contact monitoring modular and showing the goal stimulus electricity
Stream and stimulation time corresponding with the goal stimulus electric current；
The D/A converter module, for the goal stimulus electric current that the adjustment module is exported to be converted into simulation from digital current
Electric current, and export to constant current source module the goal stimulus electric current according to analog current；
The constant current source module, for exporting the first control signal to the stereotaxic apparatus.
4. equipment according to claim 3, it is characterised in that default stimulus modality mapping table includes：Stimulus of direct current mould
Formula, impulse stimulation pattern, sinusoidal stimulus modality and pseudo- stimulus modality, wherein, the adjustable frequency model of the sinusoidal stimulus modality
Enclose for：0.01-250HZ, the adjustable pulse cycle 100-2000ms of the impulse stimulation pattern, the adjustable pulse width of the impulse wave
Scope is 100-2000ms.
5. equipment according to claim 3, it is characterised in that the stimulation instrument also includes：Detection module, control module with
And alarm module；Wherein, the detection module is used to detect the size and the stimulation time of the stimulating current；
The control module, for when the stimulating current is more than predetermined current threshold, to the alarm module output control
Signal；
The alarm module, for sending alarm according to the control signal；
The control module, is connected with the power management module, is additionally operable to reach preset time threshold in the stimulation time
When, control the power management module to be off.
6. a kind of method that brain damage is repaired, it is characterised in that methods described is applied to described in claim 1-5 any one
Brain damage prosthetic appliance, methods described includes：
Determine the damage brain area of acceptor, the damage brain area has at least one in following characteristics：Bleeding, ischemic, oedema, frustrate
Paradoxical discharge when lacerated wound, axonal injury and electroencephalogram；
Stimulating electrode is positioned over the first predeterminated position, wherein, it is described if the acceptor is the human patientses with brain damage
First predeterminated position is that the human patientses damage brain area correspondence scalp surface, described if the acceptor is animal class patient
First predeterminated position is the corresponding skull surface of damage brain area of the animal class patient, and the stimulating electrode is used to be received to described
The corresponding brain area of damaging of stimulating electrode described in the damage brain area of body implements stimulating current；
Reference electrode is positioned over the second predeterminated position, wherein, second predeterminated position is that the damage is removed on the acceptor
Any one position outside brain area；
The regulation parameter of brain damage prosthetic appliance is set, to determine the selected stimulus modality of the regulation parameter, the stimulation
Pattern includes stimulating current and stimulation time corresponding with the stimulating current；
According to the corresponding stimulation time of the stimulating current, the stimulation electricity is implemented to the acceptor by the stimulating electrode
Stream.
7. method according to claim 6, it is characterised in that the acceptor is the human patientses with brain damage, accordingly
, the damage brain area for determining acceptor, including：
Determine to damage brain area according to nuclear magnetic resonance, CT iconographies, electroencephalogram, electrophysiologic study result.
8. method according to claim 7, it is characterised in that the stimulating current more than 0mA and less than or equal to 2mA,
And stimulation time is less than or equal to 30min more than 0min.
9. method according to claim 7, it is characterised in that it is described by stimulating electrode be positioned over the first predeterminated position it
Before, methods described also includes：
Stereotaxic apparatus is worn on the brain of the human patientses with brain damage；
Damage brain area in the brain region of the human patientses is defined as the first predeterminated position.
10. the method according to right wants 6, it is characterised in that the acceptor is the animal class patient with brain damage, accordingly
, more than 0uA and less than or equal to 500uA, the stimulation time is less than or equal to 30min to the stimulating current more than 0min.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281635A (en) * | 2017-07-26 | 2017-10-24 | 黄勇 | Electrode physical therapy device and electrode position method |
| CN108378847A (en) * | 2018-05-10 | 2018-08-10 | 深圳柏德医疗科技有限公司 | A kind of brain electricity cap free of cleaning |
| CN108671389A (en) * | 2018-04-25 | 2018-10-19 | 中国人民解放军军事科学院军事医学研究院 | Multi-mode is wearable through cranium electric current stimulating apparatus |
| CN108939290A (en) * | 2018-06-06 | 2018-12-07 | 中国人民解放军第四军医大学 | Based on the treating depression system to shock by electricity through cranium micro-current |
| CN109011228A (en) * | 2018-09-06 | 2018-12-18 | 西安交通大学 | A kind of high spatial resolution ultrasound neuromodulation method and system |
| CN109009103A (en) * | 2018-08-31 | 2018-12-18 | 华南理工大学 | The detection of the biofeedback type disturbance of consciousness and wake-up system |
| CN110354385A (en) * | 2019-07-18 | 2019-10-22 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | Through the multi-modal electric stimulation therapeutic apparatus of cranium and its application method |
| CN111000558A (en) * | 2019-11-28 | 2020-04-14 | 深圳先进技术研究院 | Method and system capable of accurately positioning and accurately calculating brain area |
| CN112244837A (en) * | 2020-07-27 | 2021-01-22 | 长春中医药大学附属医院(吉林省中医院) | Traditional Chinese medicine therapeutic apparatus for treating memory-losing encephalopathy |
| CN114621947A (en) * | 2022-03-30 | 2022-06-14 | 中国科学院深圳先进技术研究院 | Stem cell neural differentiation regulation and control technology based on electrical stimulation |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997045160A1 (en) * | 1996-05-31 | 1997-12-04 | Southern Illinois University | Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation |
| CN102245253A (en) * | 2008-11-21 | 2011-11-16 | B·布罗克 | Mobile device for transcranial auto-stimulation and method for controlling and regulating the device |
| CN105999545A (en) * | 2016-06-08 | 2016-10-12 | 深圳英智科技有限公司 | Cerebral apoplexy rehabilitation device |
| CN106075731A (en) * | 2016-03-02 | 2016-11-09 | 深圳英智科技有限公司 | Based on the dyskinetic method of transcranial magnetic stimulation treatment post-stroke |
| CN106581854A (en) * | 2016-11-16 | 2017-04-26 | 西安交通大学 | Transcranial direct current stimulation device and work method thereof |
| CN207270564U (en) * | 2017-02-16 | 2018-04-27 | 中国人民解放军第四军医大学 | A kind of brain damage reparation and the equipment of reconstruction |
-
2017
- 2017-02-16 CN CN201710084119.5A patent/CN106861040A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997045160A1 (en) * | 1996-05-31 | 1997-12-04 | Southern Illinois University | Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation |
| CN102245253A (en) * | 2008-11-21 | 2011-11-16 | B·布罗克 | Mobile device for transcranial auto-stimulation and method for controlling and regulating the device |
| CN106075731A (en) * | 2016-03-02 | 2016-11-09 | 深圳英智科技有限公司 | Based on the dyskinetic method of transcranial magnetic stimulation treatment post-stroke |
| CN105999545A (en) * | 2016-06-08 | 2016-10-12 | 深圳英智科技有限公司 | Cerebral apoplexy rehabilitation device |
| CN106581854A (en) * | 2016-11-16 | 2017-04-26 | 西安交通大学 | Transcranial direct current stimulation device and work method thereof |
| CN207270564U (en) * | 2017-02-16 | 2018-04-27 | 中国人民解放军第四军医大学 | A kind of brain damage reparation and the equipment of reconstruction |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281635B (en) * | 2017-07-26 | 2024-01-16 | 江苏海莱新创医疗科技有限公司 | Electrode physiotherapy device and electrode positioning method |
| CN107281635A (en) * | 2017-07-26 | 2017-10-24 | 黄勇 | Electrode physical therapy device and electrode position method |
| CN108671389A (en) * | 2018-04-25 | 2018-10-19 | 中国人民解放军军事科学院军事医学研究院 | Multi-mode is wearable through cranium electric current stimulating apparatus |
| CN108378847A (en) * | 2018-05-10 | 2018-08-10 | 深圳柏德医疗科技有限公司 | A kind of brain electricity cap free of cleaning |
| CN108939290A (en) * | 2018-06-06 | 2018-12-07 | 中国人民解放军第四军医大学 | Based on the treating depression system to shock by electricity through cranium micro-current |
| CN109009103A (en) * | 2018-08-31 | 2018-12-18 | 华南理工大学 | The detection of the biofeedback type disturbance of consciousness and wake-up system |
| CN109011228A (en) * | 2018-09-06 | 2018-12-18 | 西安交通大学 | A kind of high spatial resolution ultrasound neuromodulation method and system |
| CN110354385A (en) * | 2019-07-18 | 2019-10-22 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | Through the multi-modal electric stimulation therapeutic apparatus of cranium and its application method |
| CN111000558B (en) * | 2019-11-28 | 2021-08-17 | 深圳先进技术研究院 | Method and system capable of accurately positioning and accurately calculating brain area |
| CN111000558A (en) * | 2019-11-28 | 2020-04-14 | 深圳先进技术研究院 | Method and system capable of accurately positioning and accurately calculating brain area |
| CN112244837A (en) * | 2020-07-27 | 2021-01-22 | 长春中医药大学附属医院(吉林省中医院) | Traditional Chinese medicine therapeutic apparatus for treating memory-losing encephalopathy |
| CN114621947A (en) * | 2022-03-30 | 2022-06-14 | 中国科学院深圳先进技术研究院 | Stem cell neural differentiation regulation and control technology based on electrical stimulation |
| CN114621947B (en) * | 2022-03-30 | 2023-09-08 | 中国科学院深圳先进技术研究院 | Stem cell nerve differentiation regulation and control technology based on electrical stimulation |
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Application publication date: 20170620 |