CN106860972A - A kind of intelligent novopen - Google Patents
A kind of intelligent novopen Download PDFInfo
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- CN106860972A CN106860972A CN201710053929.4A CN201710053929A CN106860972A CN 106860972 A CN106860972 A CN 106860972A CN 201710053929 A CN201710053929 A CN 201710053929A CN 106860972 A CN106860972 A CN 106860972A
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- blood sugar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B21/00—Machines, plants or systems, using electric or magnetic effects
- F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B49/00—Arrangement or mounting of control or safety devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/38—Cleaning of electrodes
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Abstract
The present invention proposes a kind of intelligent novopen, including housing, and blood sugar test module, control module, insulin is hidden, insulin refrigeration module and insulin injection module.Blood sugar test module includes reusable MEMS blood sugar test electrodes, and MEMS blood sugar test electrodes are provided with microflute, reference electrode, working electrode and to electrode fabrication in microflute.Blood sugar test module includes electrode clean liquid and electrode clean conduit, for the cleaning to blood sugar test electrode.The blood glucose value that the insulin dosage that insulin injection module is injected can be measured according to blood sugar monitoring module is calculated, and can also be adjusted manually on this basis.The present invention solves the problems, such as that blood sugar test test strips can not be reused in the prior art, the blood sugar concentration of diabetic can not control the problem of the consumption of insulin injection, solving novopen in the prior art simultaneously needs refrigeration, carries with the problem of inconvenience.
Description
Technical field
The invention belongs to home medical apparatus, more particularly, to a kind of intelligent novopen.
Background technology
Diabetic need to carry out glycemic control by insulin injection, typically before injection of insulin, need advanced promoting circulation of blood
Sugar test, height according to blood sugar concentration adjusts the consumption of insulin.Existing blood glucose meter uses disposable blood sugar test paper
Bar, patient has carried out just calcellation discarding after a blood sugar test, can not be continuing with.The price of domestic blood sugar test paper is generally
Every 1-2 unit, such as three promises, Ai Ke, fish dive, it is happy into etc., the price of import blood sugar test paper is generally every 2-5 unit, such as Johnson ＆ Johnson, refined
Training, Omron, Bayer, Roche etc..Serious diabetic need to measure 3-4 blood sugar, the blood sugar examination of single use daily
Paper will bring certain financial burden to diabetic.If a kind of reusable blood-sugar detection sensor can be developed,
The financial burden of patient will be greatly reduced.
The injection of insulin agent of science should be adjusted according to the sugar amount of preprandial glucose concentration and dining feed, but by
In the limitation of patient's know-how, major part patient is the initial insulin consumption be given according to doctor at present, at one section
Interior holding dosage is constant, is injected.But due to the daily motion of patient, diet, condition is different, preprandial glucose
Concentration is also different, therefore injection insulin as much would also vary to the controlling extent of postprandial blood sugar.In order to preferably
Control blood sugar concentration, should test preprandial glucose concentration before feed every time, and according to current blood glucose concentration to pancreas islet
Plain consumption carries out appropriate regulation, to reduce blood glucose fluctuation.Therefore, insulin dosage is increased in insulin injection pen intelligently to count
Function is calculated, required insulin dosage can be calculated according to the current blood glucose value of patient, will more stably control the blood sugar of patient.
Insulin is refrigerated to keep its activity in need to being placed on low temperature environment, can be typically placed in refrigerator at home, when going out
Special refrigerating box need to be carried to be preserved.In existing product, blood sugar test, insulin refrigeration and injection of insulin are three
Different products are planted, when using, need to be carried respectively, use inconvenience.Therefore, develop a can not only stablizing and preserve insulin but also can
To measure blood sugar, the automatic product for calculating insulin dosage can greatly improve the quality of life of diabetic.
The content of the invention
The present invention proposes a kind of intelligentized novopen, and solve blood sugar test test strips in the prior art can not be again
The multiple problem for utilizing, the blood sugar concentration of diabetic can not control the problem of the consumption of insulin injection, while solving existing
Novopen needs refrigeration in having technology, carries with the problem of inconvenience.
Inventive concept of the invention is：For the problem that blood sugar test test strips can not be reused in the prior art, this
Invention devises one kind and is based on MEMS (Micro-Electro-Mechanical System, MEMS) processing technology
Blood sugar test electrode, etches microflute, then by photoetching process in microflute by deep etching technique in substrate material surface
Make working electrode by lithography, reference electrode and to electrode, and by enough catalysis material (such as glucose oxidase or nano-catalytic
Material) working electrode surface is fixed on, increase protective layer in catalysis material outer layer, such as polyurethane, polyurethane, Nafion, poly-
Vinylidene, makrolon, cellulose acetate, polyvinyl chloride, polytetrafluoroethylene (PTFE) etc..The protective layer can prevent catalysis material
It is lost in guard electrode simultaneously.During blood sugar test, finger tip blood is touched into eletrode tip, due to capillarity, blood can enter microflute
In, measure blood glucose value by corresponding voltage is applied on the working electrode (s.After the completion of test, electrode cleaning device outflow is can control
A certain amount of electrode clean liquid, cleans to electrode, dries rear kept dry.Due to an only 5 seconds time left side for each test
The right side, the loss during this to electrode is minimum, and catalysis material (such as glucose oxidase or nano catalytic material) is in dry ring
Can stablize in border and preserve the long period, so should reusable tens times of blood sugar test electrode.
Insulin dosage for diabetic in the prior art can not make adjustment in time according to blood sugar concentration, so that
The problem of blood sugar concentration, the present invention can not accurately be controlled increases blood sugar test function in novopen so that in insulin note
Blood sugar concentration, and the insulin dosage according to needed for patient's blood sugar concentration instantly is calculated automatically can be easily tested before penetrating,
And by automatically injecting module precise control insulin injection amount and injection speed, so as to more accurately control blood sugar concentration, protect
Demonstrate,prove the glucostasis of diabetes patient.
Need to be stored refrigerated for novopen, and the inconvenient problem of cold storage plant is carried with, the present invention is being proposed
A kind of novopen for carrying out insulin refrigeration, freezes to insulin memory block, on the one hand ensure that the work of insulin
Property, on the other hand, the smaller therefore required refrigeration in insulin memory block and heat abstractor all respective volumes are smaller, and this subtracts significantly
The small volume of refrigerating plant, facilitates diabetic to carry with.
The technical proposal of the invention is realized in this way：
Intelligent novopen includes housing, and is arranged on blood sugar test module, control module, pancreas in housing
Island element storage silo and insulin injection module；
Described blood sugar test module is used to detect the blood sugar concentration of user；
Described control module is used to obtain the blood sugar concentration data that blood sugar test module is detected, and needed for Treatment Analysis
Insulin dosage；
Described insulin storage silo is used to export a certain amount of amount of insulin to insulin injection module；
Described blood sugar test module includes reusable MEMS blood sugar test electrodes；Blood sugar test electrode basement material
Material surface etches microflute by deep etching technique, then makes working electrode, reference electrode by lithography by photoetching process in microflute
With to electrode；Wherein working electrode surface is coated with catalysis material.
Further, novopen of the present invention includes that insulin refrigerates module, and the insulin refrigerates module and passed including temperature
Sensor, semiconductor chilling plate and radiator；Temperature sensor is located at the surface of insulin storage silo, is used to test insulin storage
The temperature in storehouse, while the temperature value is passed into control module, control module controls semiconductor chilling plate according to temperature data
Work, freezes to insulin storage silo；The one side of semiconductor chilling plate is affixed on the outer wall of insulin storage silo, and another side is tight
Patch radiator, control module controls the working condition of radiator according to the working condition of semiconductor chilling plate.
Further, described blood sugar test module also includes being contained in the electrode clean liquid and electrode of electrode clean flow container
Cleaning pipe；After blood sugar test electrode carries out a blood sugar test, system control a certain amount of electrode clean liquid of outflow is to blood
The surface of sugar detection electrode is cleaned, and facilitates use next time.
Further, described blood sugar test electrode is detachably connected by electrode jockey with novopen of the present invention
Connect.
Further, the base material that described blood sugar test electrode is used is silicon, glass, quartz etc.；Reference electrode
Material is Ag/AgCl, and the material of working electrode is gold or platinum, and the material to electrode is platinum.
Further, described catalysis material outer layer increases protective layer, and the protective layer can prevent the loss of catalysis material
While guard electrode.
Further, described catalysis material is glucose oxidase or nano catalytic material.
Further, the insulin dosage that described insulin injection module is injected can be measured according to blood sugar test module
Blood glucose value be calculated, can also be adjusted manually on this basis.
It is of the invention to be advantageous in that：The present invention increased blood sugar test function in insulin injection pen so that in pancreas
Blood sugar concentration can be easily tested before the element injection of island, and according to needed for the automatic calculating of patient's blood sugar concentration instantly and control
Insulin dosage, so as to more accurately control blood sugar concentration, it is ensured that the glucostasis of diabetes patient.The system of increased miniaturization
Chill block can be refrigerated easily to insulin, it is ensured that insulin active, while improve the portable of insulin cold storage plant
Property.Increased blood sugar test function has used the blood sugar test electrode based on MEMS processing technologys, electrode production low cost and can
Repeatedly use, reduce the financial burden of diabetic.
Brief description of the drawings
Fig. 1 is the system block diagram of intellectuality novopen of the invention；
Fig. 2 is the structural representation of intellectuality novopen of the invention；
Fig. 3 is the structural representation of the blood sugar test electrode of intellectuality novopen of the invention；
Fig. 4 is the micro groove structure sectional view of the blood sugar test electrode of intellectuality novopen of the invention；
Fig. 5 is the schematic diagram that is fixed in electrode jockey of blood sugar test electrode of intellectuality novopen of the invention；
Wherein reference is as follows：Microprocessor 1, blood sugar test module 2, blood sugar test electrode 21, reference electrode 211,
Working electrode 212, to electrode 213, electrode connecting line 214, electrode connection pad 215, microflute 216, blood sugar test circuit 22, electricity
Pole jockey 23, fixture upper piece 231, fixture bottom sheet 232, electrode clean fluid catheter through hole 233, electrode clean liquid 24, electrode
Cleaning fluid tank 25, electrode clean fluid catheter 26, insulin refrigeration module 3, temperature sensor 31, semiconductor chilling plate 32, radiating
Device 33, fin 331, radiator fan 332, insulin storage silo 4, metal warehouse 41, heat insulation layer 42, insulin conveying end 43,
Insulin pen-cartridge 44, advances lid 45, and elastic membrane 46, insulin injection module 5, micromass culture pump 51, micromass culture motor 511 is micro- to push away
Enter bar 512, injection of insulin syringe needle 52, injection of insulin needle cap 53, display module 6, button 7 (control button 71 and 72),
Power module 8, battery 81, power control circuit 82, housing 9, insulin storehouse opening 91, insulin syringe needle through hole 92, battery fills
Electrical interface 93, thermal vias 94, blood sugar test lid 95, electrode clean liquid filling opening 96, button and display control circuit 10.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Whole description, it is clear that described embodiment only not Fa a part of embodiment of name, rather than whole embodiments.It is based on
Embodiments of the invention, it is every other that one of ordinary skill in the art is obtained under the premise of creative work is not made
Embodiment, belongs to protection scope of the present invention.
As shown in figure 1, present invention intellectuality novopen includes microprocessor 1, blood sugar test module 2, insulin refrigeration
Module 3, insulin storage silo 4, insulin injection module 5, display module 6, button 7 and power module 8.Wherein insulin refrigeration
Module 3 includes temperature sensor 31, semiconductor chilling plate 32 and radiator 33, and insulin injection module 5 includes micromass culture pump 51
With injection of insulin syringe needle 52.The control blood sugar test of microprocessor 1 module 2 tests blood sugar, and blood sugar test module 2 measures what is obtained
Data are transferred to microprocessor 1, and microprocessor 1 is calculated required pancreas islet according to the blood glucose value according to existing ripe algorithm
Plain consumption.The control micromass culture of microprocessor 1 pump 51 pumps out the insulin of phase application amount from insulin storage silo 4, and by pancreas
Island element injection needle 52 is injected into diabetic's body.Insulin refrigeration module 3 is used for the refrigeration of insulin, temperature sensor
31 surfaces for being located at insulin storage silo 4, the temperature of test insulin storage silo 4, while the temperature value is passed into microprocessor
Device 1, microprocessor 1 controls the work of semiconductor chilling plate 32 according to temperature data, and insulin storage silo 4 is freezed.Half
The one side of conductor cooling piece 32 is affixed on the outer wall of insulin storage silo 4, another side held against heat sink 33, and microprocessor 1 is according to half
The working condition of conductor cooling piece 32, controls the working condition of radiator 33.Power module 8 is microprocessor 1, blood sugar test mould
Block 2, insulin refrigeration module 3, micromass culture pump 51, display 6 and control button 7 provide power supply.
Described microprocessor 1 can select the single-chip microcomputer of low-power consumption, such as the MSP430 series monolithics of Texas Instrument, Dezhou
The SimpleLink C26 series monolithics of instrument, Atmel SAML21 series, STMicw Electronics's STM32L4 series etc..
Fig. 2 is the structure chart of novopen of the present invention.
Intelligent novopen consists of the following components：
Housing 9 is provided with insulin storehouse opening 91, insulin syringe needle through hole 92, battery charging inlet 93, thermal vias 94,
Blood sugar test lid 95, electrode clean liquid filling opening 96, control button 71 and 72, display 6.Insulin storehouse opening 91 is used to take out
With placing insulin pen core 44, insulin syringe needle through hole 92 is used for injection of insulin syringe needle and stretches out, and battery charging inlet 93 is used
Charged in battery 81, thermal vias 94 are used for the radiating that insulin refrigerates module 3, blood sugar test lid 95 is used to protect blood sugar to examine
Electrode 21 is surveyed, can be opened when using carries out blood sugar test, after electrode clean liquid filling opening 96 is opened, electrode clean liquid can be carried out
Liquid feeding.Control button 71 and 72 is used to be configured the parameter of novopen, and such as refrigerated storage temperature is set, and insulin injection amount is adjusted
It is whole etc..Display 6 is used to show the working condition of novopen, such as blood glucose value, insulin dosage, insulin refrigerated storage temperature etc..
The working condition of button 71 and 72 and display 6 can be regulated and controled by button and display control circuit 10.
Power module 8 includes battery 81 and power control circuit 82.
Blood sugar test module 2 includes blood sugar test electrode 21, and blood sugar test circuit 22, electrode jockey 23 and electrode are clear
Washing lotion 24；Blood sugar test electrode 21 is connected by electrode jockey 23 with novopen of the present invention, and blood sugar test circuit 22 leads to
The concentration of glucose crossed in the test blood of blood sugar test electrode 21.
Insulin storage silo 4 includes metal warehouse 41 and heat insulation layer 42, and the side wall of insulin storage silo 4 is provided with insulin and takes
Outlet 43, the insulin conveying end 43 is placed exactly at insulin storehouse opening 91.Insulin pen-cartridge 44 is positioned over insulin storage
In storehouse 4.The chill surface of semiconductor chilling plate 32 is close to the outer wall of the metal warehouse 41 of insulin storage silo 4, for pancreas islet
The refrigeration of plain storage silo 4.The radiating surface of semiconductor chilling plate 32 is close to radiator 33, and radiator 33 includes the He of fin 331
Radiator fan 332, radiator 33 is used for the radiating to semiconductor chilling plate 32.The temperature of insulin storage silo 4 can be by pancreas islet
Element refrigeration control circuit 34 regulates and controls to the working condition of semiconductor chilling plate 32.
Micromass culture pump 51 includes micromass culture motor 511 and micromass culture bar 512, and micro- pushing away is fixed in one end of micromass culture bar 512
In stepper motor 511, the other end is brought into close contact with the propulsion lid 45 of insulin pen-cartridge 44, and micromass culture motor 511 drives micro- when rotating
Pushing ram 512 advances, and promotes propulsion lid 45, and the insulin in insulin pen-cartridge 44 is released.The bottom of insulin pen-cartridge 44 is
Elastic membrane 46, injection of insulin needle cap 53 is fixed on housing 9, and injection of insulin syringe needle 52 passes through the insulin on housing 9
Syringe needle through hole 92, and the elastic membrane 46 of insulin pen-cartridge 44 is penetrated, the insulin in insulin pen-cartridge 44 is in micromass culture motor 511
Impetus under, from injection of insulin syringe needle 52 flow out.The injection volume of insulin can control circuit 54 by injection of insulin
Regulated and controled.
The structure of blood sugar test electrode 21 as shown in figure 3, electrode is made using micro fabrication, electrode base materials
It is silicon, glass, quartz etc..Blood sugar test electrode 21 is constituted by reference electrode 211, working electrode 212 and to electrode 213, reference
The material of electrode 211 is Ag/AgCl, and the material of working electrode 212 is gold or platinum, and the material to electrode 213 is platinum.Reference electrode
211, working electrode 212 and the size to electrode 213 are 50um-500um.Working electrode 212 can be have enzyme electrode, it is also possible to
It is without enzyme electrode.When working electrode 212 is to there is enzyme electrode, electrode surface is fixed with enough glucose oxidases, for urging
Change the glucose in blood, there is layer protective layer on glucose oxidase surface, on the one hand can be with guard electrode, in reduction blood
Biochemical substances cause corrosion to electrode, and glucose oxidase on the other hand can be prevented to be lost in, and extend the service life of electrode.When
When working electrode 212 is without enzyme electrode, electrode surface not immobilized enzyme can select the nano material with catalysis activity as Portugal
The catalyst of grape sugar reaction, such as Pt nano particle, Au, Pd noble metal and Ni and Cu metals and oxide, also CNT, stone
These materials are fixed on the surface of working electrode 212 by the nano materials such as black alkene, equally also need one layer in these nano-material surfaces
Protective layer.Reference electrode 211, working electrode 212 and is connected pad 215 with electrode and connects to electrode 213 by electrode connecting line 214
Connect, the material of electrode connecting line 214 and electrode connection pad 215 is gold.The size of electrode connection pad 215 is 200um-1mm.
As shown in figure 4, the silicon substrate surface of blood sugar test electrode 21 forms microflute 216, microflute 216 by deep etching process
Length be 1mm-10mm, depth is 50um-200um, and width is 100um-1mm.Reference electrode 211, working electrode 212 and right
Electrode 213 is produced in microflute 216.When needing to carry out blood sugar test, patient punctures finger tip and extrudes by disposable blood taking needle
Drop of blood, and finger tip drop of blood is placed the eletrode tip of blood sugar test electrode 21, when microflute 216 touches drop of blood, because capillary is made
With blood can be automatically drawn into microflute 216, and corresponding voltage is applied on electrode, and the glucose in blood is solid in electrode surface
Under the catalytic action of fixed catalysis material, such as glucose oxidase or nano material, you can produce corresponding electric current, by surveying
Examination size of current, you can measure the concentration of glucose in blood.
Fig. 5 is the schematic diagram that blood sugar test electrode 21 is fixed in electrode jockey 23, and electrode jockey 23 includes
Fixture upper piece 231 and fixture bottom sheet 232, the lower surface of fixture upper piece 231 have and are connected pad with the electrode of blood sugar test electrode 21
215 one-to-one signal connection pads 234.When blood sugar test electrode 21 is fixed in electrode jockey 23, blood sugar inspection
The electrode connection pad 215 on survey electrode 21 surface is just connected pad 234 with the signal of fixture upper piece 231 and aligns and fit tight
Close, voltage signal can be put on system the reference electrode 211 of blood sugar test electrode 21, work electricity by the pad fitted up and down
Pole 212 and on electrode 213, the signal produced by glucose in blood can also be drawn by the pad fitted up and down.Electrode
There is electrode clean fluid catheter through hole 233 on the fixture upper piece 231 of jockey 23, for fixed electrode cleaning liquor pipe 26.When
After blood sugar test electrode 21 carries out a blood sugar test, system a certain amount of electrode clean liquid 24 of control outflow is to blood sugar test electricity
The surface of pole 21 is cleaned, and facilitates use next time.
The blood sugar test electrode that existing blood glucose meter is used for single use blood sugar test paper bar, patient's use cost compared with
It is high.The present invention devises a kind of MEMS blood sugar tests electrode, and electrode surface can be rinsed and dried by cleaning fluid after having tested,
Due to only 5 seconds or so the time of each test, the loss during this to electrode is minimum, glucose oxidase or nano-catalytic
Thing can be stablized the preservation long period in a dry environment, so the blood sugar test electrode reusable tens in the present invention
It is secondary.Serious diabetic need to measure 3-4 blood sugar daily, and general patient only needs measurement once daily, or several days survey
Once, then the blood sugar test electrode in the present invention can be used continuously more than ten days to some months amount.MEMS processing technologys can lead to simultaneously
Crossing large-scale production reduces production cost, and the cost of electrode is close even lower with the blood sugar test paper bar of single use, so that
Greatly reduce the financial burden of patient.
The present invention increased blood sugar test function in insulin injection pen so that can be easily before injection of insulin
Test blood sugar concentration, and calculated automatically according to patient's blood sugar concentration instantly and control required insulin dosage, so that more
Blood sugar concentration is controlled exactly, it is ensured that the glucostasis of diabetes patient.The refrigeration module of increased miniaturization can easily to pancreas
Island element is refrigerated, it is ensured that insulin active, while improve the portability of insulin cold storage plant.
Above-described embodiment is not that, for limitation of the invention, the present invention is not limited only to above-described embodiment, as long as meeting
Application claims, belong to protection scope of the present invention.
Claims (9)
1. a kind of intelligent novopen, it is characterised in that including housing, and it is arranged on blood sugar test module, control in housing
Molding block, insulin storage silo and insulin injection module；
Described blood sugar test module is used to detect the blood sugar concentration of user；
Described control module is used to obtain the blood sugar concentration data that blood sugar test module is detected, and the pancreas needed for Treatment Analysis
Island element consumption；
Described insulin storage silo is used to export a certain amount of amount of insulin to insulin injection module；
Described blood sugar test module includes blood sugar test electrode；Blood sugar test electrode base materials surface passes through deep etching technique
Etch microflute, then working electrode is made by lithography by photoetching process in microflute, reference electrode and to electrode；Wherein working electrode
Surface is coated with catalysis material.
2. a kind of intelligent novopen as claimed in claim 1, it is characterised in that also refrigerate module, the pancreas including insulin
Island element refrigeration module includes temperature sensor, semiconductor chilling plate and radiator；Temperature sensor is located at insulin storage silo
Surface, is used to test the temperature of insulin storage silo, while the temperature value is passed into control module, control module is according to temperature
Data control the work of semiconductor chilling plate, and insulin storage silo is freezed；The one side of semiconductor chilling plate is affixed on pancreas islet
The outer wall of plain storage silo, another side held against heat sink, control module controls radiator according to the working condition of semiconductor chilling plate
Working condition.
3. a kind of intelligent novopen as claimed in claim 1, it is characterised in that described blood sugar test module also includes
It is contained in the electrode clean liquid and electrode clean conduit of electrode clean flow container；When blood sugar test electrode carries out a blood sugar test
Afterwards, a certain amount of electrode clean liquid of system control outflow is cleaned to the surface of blood sugar test electrode, facilitates use next time.
4. a kind of intelligent novopen as claimed in claim 1, it is characterised in that described blood sugar test electrode and pancreas islet
Plain pen is detachably connected.
5. a kind of intelligent novopen as claimed in claim 1, it is characterised in that what described blood sugar test electrode was used
Base material is silicon, glass, quartz etc.；The material of reference electrode is Ag/AgCl, and the material of working electrode is gold or platinum, to electricity
The material of pole is platinum.
6. a kind of intelligent novopen as claimed in claim 1, it is characterised in that described catalysis material outer layer increases to be protected
Sheath, the protective layer can prevent the loss of catalysis material while guard electrode.
7. a kind of intelligent novopen as claimed in claim 1, it is characterised in that described catalysis material is grape glycosyloxy
Change enzyme or nano catalytic material.
8. a kind of intelligent novopen as claimed in claim 1, it is characterised in that described insulin injection module is noted
The blood glucose value that the insulin dosage penetrated can be measured according to blood sugar test module is calculated, and can also be adjusted manually on this basis
Section.
9. a kind of intelligent novopen as claimed in claim 1, it is characterised in that the front end of blood sugar test electrode is using point
End formula, and microflute is located at the front end of blood sugar test electrode；When drop of blood is touched in the front end of blood sugar test electrode, because capillary is made
With blood is automatically drawn into microflute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710053929.4A CN106860972B (en) | 2017-01-22 | 2017-01-22 | Intelligent insulin pen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710053929.4A CN106860972B (en) | 2017-01-22 | 2017-01-22 | Intelligent insulin pen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106860972A true CN106860972A (en) | 2017-06-20 |
| CN106860972B CN106860972B (en) | 2022-10-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710053929.4A Active CN106860972B (en) | 2017-01-22 | 2017-01-22 | Intelligent insulin pen |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108744112A (en) * | 2018-03-27 | 2018-11-06 | 江苏信息职业技术学院 | A kind of incubation chamber monitoring injection of insulin number and its method for monitoring |
| CN109758644A (en) * | 2019-03-05 | 2019-05-17 | 李晓彤 | A kind of device of synchronous detection blood glucose and insulin injection |
| CN111658900A (en) * | 2020-06-11 | 2020-09-15 | 浙江中医药大学附属第三医院 | Diabetes injection device |
| US10881787B2 (en) | 2017-10-27 | 2021-01-05 | Microjet Technology Co., Ltd. | Wearable liquid supplying device for human insulin injection |
| CN112286262A (en) * | 2019-07-13 | 2021-01-29 | 宁波泽世医疗科技有限公司 | Medicine environment control device and medicine storage device |
| CN112933343A (en) * | 2021-04-07 | 2021-06-11 | 吴道爱 | Insulin pen |
| CN113663162A (en) * | 2021-09-21 | 2021-11-19 | 南通市第二人民医院 | Portable automatic insulin injection device with blood sugar measuring function |
| CN114010879A (en) * | 2021-12-02 | 2022-02-08 | 郭潘婷 | Intelligent quantity-control type insulin needleless injection pen and injection system |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1566939A (en) * | 2003-06-18 | 2005-01-19 | 清华大学 | Biomedical anodynia blood taking micro needle chip and method for making same |
| US20120046606A1 (en) * | 2010-08-18 | 2012-02-23 | Thuban, Inc. | Integrated glucose monitor and insulin injection pen with automatic emergency notification |
| CN103454325A (en) * | 2013-09-04 | 2013-12-18 | 上海移宇科技有限公司 | Photocatalysed glucose microelectrode sensor and preparation method thereof |
| CN103543180A (en) * | 2013-10-30 | 2014-01-29 | 南京林业大学 | Immune impedance biosensor detection method and device for quick pesticide residue detection |
| CN104931568A (en) * | 2015-06-29 | 2015-09-23 | 彭梓 | Indium tin oxide electrochemiluminescence reaction electrode regeneration cleaning method |
| CN204995483U (en) * | 2015-07-10 | 2016-01-27 | 杭州电子科技大学 | Have insulin cold storage plant that blood sugar detected concurrently |
| CN105880204A (en) * | 2016-05-06 | 2016-08-24 | 南京医科大学 | Fast cleaning method for gold-bearing matrix detection plate for cell analyzer |
| CN205758571U (en) * | 2016-05-19 | 2016-12-07 | 杭州宇壳科技有限公司 | Flexible electrochemical electrode and subcutaneous continuous glucose monitoring sensor |
-
2017
- 2017-01-22 CN CN201710053929.4A patent/CN106860972B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1566939A (en) * | 2003-06-18 | 2005-01-19 | 清华大学 | Biomedical anodynia blood taking micro needle chip and method for making same |
| US20120046606A1 (en) * | 2010-08-18 | 2012-02-23 | Thuban, Inc. | Integrated glucose monitor and insulin injection pen with automatic emergency notification |
| CN103454325A (en) * | 2013-09-04 | 2013-12-18 | 上海移宇科技有限公司 | Photocatalysed glucose microelectrode sensor and preparation method thereof |
| CN103543180A (en) * | 2013-10-30 | 2014-01-29 | 南京林业大学 | Immune impedance biosensor detection method and device for quick pesticide residue detection |
| CN104931568A (en) * | 2015-06-29 | 2015-09-23 | 彭梓 | Indium tin oxide electrochemiluminescence reaction electrode regeneration cleaning method |
| CN204995483U (en) * | 2015-07-10 | 2016-01-27 | 杭州电子科技大学 | Have insulin cold storage plant that blood sugar detected concurrently |
| CN105880204A (en) * | 2016-05-06 | 2016-08-24 | 南京医科大学 | Fast cleaning method for gold-bearing matrix detection plate for cell analyzer |
| CN205758571U (en) * | 2016-05-19 | 2016-12-07 | 杭州宇壳科技有限公司 | Flexible electrochemical electrode and subcutaneous continuous glucose monitoring sensor |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10881787B2 (en) | 2017-10-27 | 2021-01-05 | Microjet Technology Co., Ltd. | Wearable liquid supplying device for human insulin injection |
| CN108744112A (en) * | 2018-03-27 | 2018-11-06 | 江苏信息职业技术学院 | A kind of incubation chamber monitoring injection of insulin number and its method for monitoring |
| CN108744112B (en) * | 2018-03-27 | 2023-07-18 | 江苏信息职业技术学院 | Insulation box capable of monitoring insulin injection times and method for monitoring insulation box |
| CN109758644A (en) * | 2019-03-05 | 2019-05-17 | 李晓彤 | A kind of device of synchronous detection blood glucose and insulin injection |
| CN109758644B (en) * | 2019-03-05 | 2023-08-08 | 李晓彤 | Device for synchronously detecting blood sugar and injecting insulin |
| CN112286262A (en) * | 2019-07-13 | 2021-01-29 | 宁波泽世医疗科技有限公司 | Medicine environment control device and medicine storage device |
| CN111658900A (en) * | 2020-06-11 | 2020-09-15 | 浙江中医药大学附属第三医院 | Diabetes injection device |
| CN112933343A (en) * | 2021-04-07 | 2021-06-11 | 吴道爱 | Insulin pen |
| CN113663162A (en) * | 2021-09-21 | 2021-11-19 | 南通市第二人民医院 | Portable automatic insulin injection device with blood sugar measuring function |
| CN113663162B (en) * | 2021-09-21 | 2022-12-23 | 南通市第二人民医院 | Portable automatic insulin injection device with blood sugar measuring function |
| CN114010879A (en) * | 2021-12-02 | 2022-02-08 | 郭潘婷 | Intelligent quantity-control type insulin needleless injection pen and injection system |
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