CN106859629A - Ambient noise weakens system and method in magneticencephalogram detection - Google Patents
Ambient noise weakens system and method in magneticencephalogram detection Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A61B5/6813—Specially adapted to be attached to a specific body part
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Abstract
Weaken system and method the present invention relates to ambient noise in a kind of detection of magneticencephalogram, wear flexible substrate outside and be provided with array of magnetic sensors layer, brain array of magnetic field and external magnetic field sensor array are distributed in two hemisphere of brain or so, and array of magnetic sensors layer is outside to be provided with magnetic masking layer；Wearable magnetic field sensor neck ring is arranged on neck.By collection analysis head brain magnetic field and head external magnetic field, analysis neck brain magnetic field and neck external magnetic field, brain Magnetic Field is merged, noise analysis is carried out to outside Magnetic Field, obtain reference noise background signal, fusion brain Magnetic Field subtracts reference noise background signal, realize that the ambient noise in magneticencephalogram detection is slackened, obtain high s/n ratio magneticencephalogram.With system and method it is simple, be easy to implement, sensitivity is high, cost of implementation is low, high reliability, space is small, flexibility is strong the features such as.
Description
Technical field
Weaken system and method the present invention relates to a kind of ambient noise, ambient noise is cut in particularly a kind of magneticencephalogram detection
Weak system and method, main brain science, life medical treatment, biotechnology, health detection, disease treatment, man-machine interaction, intelligence control
Magneticencephalogram detection ambient noise in the fields such as system, behavior tissue weakens system and method.
Background technology
Magneticencephalogram (Magnetoencephalography, abbreviated as MEG) detection is that a kind of, nothing completely non-invasive to human body is put
The Brain mapping of penetrating property as Detection Techniques, in brain science, life medical treatment, biotechnology, health detection, disease treatment, man-machine friendship
Mutually, very important effect is played in the field such as Based Intelligent Control, behavior tissue.Magneticencephalogram need not contact skin, will not occur
Thus the artifact for occurring, with the active state of direct reaction intracerebral magnetic field sources, and can determine that intensity and the position of magnetic field sources.Depending on
Feel and induce brain magnetic field, brainstem auditory evoked brain magnetic field induces brain magnetic field with body has specificity, can tell tissue and function
Upper different cell colony.Before magneticencephalogram may apply to operation prelocalization, the neurosurgery of Diagnosis of Epilepsy and Epileptic focus
Brain after diagnosis, the wound of cerebral function area positioning, ischemic cerebrovascular disease prediction and diagnosis, mental disease and mental handicape disease
Functional assessment, judicial expertise, detect a lie, language, vision, the sense of hearing, body-sensing induce etc. research.
Because brain magnetic field is very weak, need to weaken outside noise in magneticencephalogram detection, improve brain magnetic field detection signal to noise ratio.
In the presence of more universal method it is exactly to build magnetic shield room in first technology, magneticencephalogram instrument is placed in magnetic shield room, this side
Method implementation process is complicated, to external world condition requirement height, high cost, need that space is big, limit magneticencephalogram instrument uses flexibility.Formerly
There is another method in technology, see United States Patent (USP), patent name is Noise cancellation in
magnetoencephalography and electroencephalography with isolated reference
Sensors, granted patent number is US7729740B2, and the license time is on 01 01st, 2010, and the present invention is passed using increase
The mode of sensor, master reference and reference sensor are provided with the both sides of the electromagnetic-field-shielded layer set up, and master reference is being leaned on
Nearly party to be detected side, reference sensor is arranged on ambient noise side, correcting signal, main sensing is obtained by reference to sensor
Device signal subtracts correcting signal and obtains noise-free signal（noise-free singal）, this first technology have the advantages that it is suitable,
But have that some essence are not enough, system architecture is complicated, implementation process is lengthy and tedious, be not easy to realize, increase cost, influence detects property
Energy, restricted application.
The content of the invention
Deficiency it is an object of the invention to be directed to above-mentioned technology, there is provided ambient noise weakens system in a kind of magneticencephalogram detection
System and method, the system have that succinct, method is simple, flow is succinct, be easy to implement, sensitivity is high, cost of implementation is low, real-time
Good, high reliability, high stability, need that space is small, flexibility is strong, do not influence detection performance, function to be easy to expand, range of application
Wide the features such as.
The technical scheme is that：Ambient noise weakens system in a kind of magneticencephalogram detection, including wears flexible liner
Bottom, array of magnetic sensors layer, wearable magnetic field sensor neck ring,：The flexible substrate outside of wearing is provided with Magnetic Sensor battle array
Row layer, array of magnetic sensors layer is made up of brain array of magnetic field and external magnetic field sensor array, brain array of magnetic field
Two hemisphere of brain or so are distributed in external magnetic field sensor array, array of magnetic sensors layer is outside to be provided with magnetic masking layer；Institute
State wearable magnetic field sensor neck ring and be arranged on neck, wearable magnetic field sensor neck ring is by brain magnetic field sensor circular array
Row, external magnetic field sensor annular array are constituted；The brain array of magnetic field is by head brain magnetic field analysis module and described
External magnetic field sensor array connects magneticencephalogram synthesis module respectively by head external magnetic field analysis module；The brain magnetic field sensor
Annular array analyzes mould by neck brain magnetic field analysis module and the external magnetic field sensor annular array by neck external magnetic field
Block connects magneticencephalogram synthesis module respectively.
Magnetic field sensor is alkali metal atom magnetic field sensor.
Ambient noise weakens the noise attenuation method of system, first, brain magnetic field sensor in a kind of application magneticencephalogram detection
Array detection is transmitted to head brain magnetic field analysis module and is analyzed to brain Magnetic Field, and external magnetic field sensor array is by the outer magnetic of head
Field information is transmitted to head external magnetic field analysis module carries out Analysis of Noise Properties；Meanwhile, the brain magnetic of wearable magnetic field sensor neck ring
Neck region brain Magnetic Field is transmitted to neck brain magnetic field analysis module and is analyzed by field sensor annular array, wearable
Neck region external magnetic field information is transmitted to neck external magnetic field point by the external magnetic field sensor annular array of magnetic field sensor neck ring
Analysis module carries out external noise analysis；Then, head brain magnetic field analysis module, neck brain magnetic field analysis module, head external magnetic field
Magnetic Field is transferred to magneticencephalogram synthesis module by analysis module, neck external magnetic field analysis module, and magneticencephalogram synthesis module is by brain
Magnetic Field is merged, and noise analysis is carried out to outside Magnetic Field, obtains reference noise background signal, fusion brain magnetic field letter
Breath subtracts reference noise background signal, realizes that the ambient noise in magneticencephalogram detection is slackened, and obtains high s/n ratio magneticencephalogram.
The head external magnetic field analysis module is associated with brain magnetic field based on external magnetic field frequency characteristic, and external magnetic field
Degree, magnetic field carries out signature analysis and intensity distribution calculates assessment to external world, obtains the external magnetic field point that there is interference to brain magnetic field
Cloth.
The neck external magnetic field analysis module is associated with brain magnetic field based on external magnetic field frequency characteristic, and external magnetic field
Degree, magnetic field carries out signature analysis and intensity distribution calculates assessment to external world, obtains outside the neck area to brain magnetic field in the presence of interference
Boundary's Distribution of Magnetic Field.
Compared with prior art, the beneficial effects of the invention are as follows：
1）Magnetic shield room is built in first technology or by the way of sensor is increased, in the both sides of the electromagnetic-field-shielded layer set up
Master reference and reference sensor are provided with, near party to be detected side, reference sensor is arranged on environment and makes an uproar master reference
Sound side, correcting signal is obtained by reference to sensor, and master reference signal subtracts correcting signal and obtains noise-free signal, has
Implementation process is complicated, to external world condition requirement height, high cost, need that space is big, limitation magneticencephalogram instrument uses the deficiencies such as flexibility.
The present invention is based on brain magnetic field and Magnetic Sensor characteristic, using small space shielding techniques, and by head Magnetic testi and neck magnetic
Detection is combined, and respectively in head and neck collection brain magnetic field and external magnetic field information, analysis is obtained after wearing magnetic screen
Reference noise background signal, fusion brain Magnetic Field subtract reference noise background signal, realize magneticencephalogram detection in background
Noise is slackened, and obtains high s/n ratio magneticencephalogram, with system it is succinct, method is simple, flow is succinct, be easy to implement, sensitivity is high,
The low feature of cost of implementation；
2）The principle of the Magnetic Sensor of external condition and use, poor real, information analysis are limited on first technological essence
Flow is cumbersome, influence detection performance, restricted application.The present invention carries out neck brain magnetic using brain part magnetic screen
Field and external magnetic field detection, information data fully, Magnetic Field are disturbed using head and the collection of neck external magnetic field sensor array,
And analyzed and processed, interference magnetic field is deducted in the brain Magnetic Field for collecting, high s/n ratio is realized, with when property is good, Gao Ke
By property, high stability, need that space is small, flexibility strong, do not influence detection performance, function to be easy to expand, the spy such as have a wide range of application
Point.
Brief description of the drawings
Fig. 1 is ambient noise weakening system schematic in magneticencephalogram of the invention detection.
Specific embodiment
The invention will be further described with reference to the accompanying drawings and examples.
As shown in figure 1, ambient noise weakens system in a kind of magneticencephalogram detection, including wear flexible substrate 1, Magnetic Sensor
Array layer 2, magnetic masking layer 3, wearable magnetic field sensor neck ring 4, head brain magnetic field analysis module 5, head external magnetic field analysis mould
Block 6, neck brain magnetic field analysis module 7, neck external magnetic field analysis module 8, magneticencephalogram synthesis module 9.
Wear the outside of flexible substrate 1 and be provided with array of magnetic sensors layer 2, array of magnetic sensors layer 2 is by brain magnetic field sensor
Array 201 and external magnetic field sensor array 202 are constituted, and brain array of magnetic field 201 and external magnetic field sensor array 202 are distributed
Magnetic masking layer 3 is provided with outside two hemisphere of brain or so, array of magnetic sensors layer 1；Wearable magnetic field sensor neck ring 4 sets
Put in neck, wearable magnetic field sensor neck ring 4 is by brain magnetic field sensor annular array 401, external magnetic field sensor annular
Array 402 is constituted；Brain array of magnetic field 201 is logical by head brain magnetic field analysis module 5 and external magnetic field sensor array 202
Cross head external magnetic field analysis module 6 and connect magneticencephalogram synthesis module 9 respectively；Brain magnetic field sensor annular array 401 passes through neck
Brain magnetic field analysis module 7 and external magnetic field sensor annular array 402 connect magneticencephalogram respectively by neck external magnetic field analysis module 8
Synthesis module 9.
Ambient noise weakens method in magneticencephalogram detection of the invention, based on brain magnetic field and Magnetic Sensor characteristic, using small
Space shielding techniques, and head Magnetic testi and neck Magnetic testi are combined, respectively in head and neck collection brain magnetic field
With external magnetic field information, analyze and obtain the reference noise background signal after wearing magnetic screen, fusion brain Magnetic Field is subtracted
Reference noise background signal, realizes that the ambient noise in magneticencephalogram detection is slackened, and obtains high s/n ratio magneticencephalogram.Step of the present invention
In be related to multiple module to use, module is not limited to hardware module, and the encapsulation function bag of software analysis method or step is also referred to as
It is module.
The step that implements of the present embodiment is：
Step (1) is provided with array of magnetic sensors layer 2 wearing the outside of flexible substrate 1, and array of magnetic sensors layer 2 is passed by brain magnetic field
Sensor array 201 and external magnetic field sensor array 202 are constituted, brain array of magnetic field 201 and external magnetic field sensor array 202
Two hemisphere of brain or so are distributed in, magnetic masking layer 3, brain array of magnetic field 201 are provided with outside array of magnetic sensors layer 1
Atomic magnetic force sensor forming array is used with external magnetic field sensor array 202；
Step (2) neck is provided with wearable magnetic field sensor neck ring 4, and wearable magnetic field sensor neck ring 4 is by brain magnetic field
Sensor annular array 401 and external magnetic field sensor annular array 402 are constituted, brain magnetic field sensor annular array 401 and outer magnetic
Field sensor annular array 402 is by atomic magnetic force sensor forming array；
Step (3) brain array of magnetic field 201 detects brain Magnetic Field and is transmitted to head brain magnetic field analysis module 5 is divided
Head external magnetic field information is transmitted to head external magnetic field analysis module 6 and carries out noise characteristic point by analysis, external magnetic field sensor array 202
Analysis, head external magnetic field analysis module 6 is based on external magnetic field frequency characteristic, and external magnetic field and the brain magnetic field degree of association, to external world
Magnetic field carries out signature analysis and intensity distribution calculates assessment, obtains the external magnetic field distribution that there is interference to brain magnetic field；
Step (4) is implemented simultaneously in step 3, and the brain magnetic field sensor annular array 401 of wearable magnetic field sensor neck ring 4 is by people
Body neck area brain Magnetic Field is transmitted to neck brain magnetic field analysis module 7 and is analyzed, outside wearable magnetic field sensor neck ring 4
Neck region external magnetic field information is transmitted to neck external magnetic field analysis module 8 and carries out outside by magnetic field sensor annular array 402
Noise analysis, neck external magnetic field analysis module 8 is based on external magnetic field frequency characteristic, and external magnetic field and the brain magnetic field degree of association,
Magnetic field carries out signature analysis and intensity distribution calculates assessment to external world, obtains the neck area external world magnetic that there is interference to brain magnetic field
Field distribution；
Outside step (5) head brain magnetic field analysis module 5, neck brain magnetic field analysis module 7, head external magnetic field analysis module 6, neck
Magnetic Field is transferred to magneticencephalogram synthesis module 9 by magnetic field analysis module 8, and magneticencephalogram synthesis module 9 carries out brain Magnetic Field
Fusion, noise analysis is carried out to outside Magnetic Field, obtains reference noise background signal, and fusion brain Magnetic Field is subtracted to refer to and made an uproar
Sound background signal, realizes that the ambient noise in magneticencephalogram detection is slackened, and obtains high s/n ratio magneticencephalogram.
The present embodiment correspondence is used in brain magnetic field detection, using Rd alkali metal atom magnetometric sensors, realizes 0.5mm empty
Between resolution ratio, sensitivity reaches the brain Distribution of Magnetic Field figure of 2fT, and signal to noise ratio improves 2 times, has reached the background in magneticencephalogram detection
Noise attenuation effect, with system it is succinct, method is simple, flow is succinct, be easy to implement, sensitivity is high, cost of implementation is low, real-time
Property good, high reliability, high stability, need that space is small, flexibility strong, do not influence detection performance, function to be easy to expand, using model
The features such as enclosing wide.
Magnetic field sensor and its application method, Magnetic Field treatment, mechanical structure, SECO feature are carried in the present invention
Take, module construction, signal processing algorithm etc. are mature technology, inventive point of the invention is based on brain magnetic field and Magnetic Sensor
Characteristic, using small space shielding techniques, and head Magnetic testi and neck Magnetic testi is combined, respectively in head and neck
Collection brain magnetic field and external magnetic field information, analysis obtain the reference noise background signal after wearing magnetic screen, merge brain magnetic
Field information subtracts reference noise background signal, realizes that the ambient noise in magneticencephalogram detection is slackened, and obtains high s/n ratio magneticencephalogram,
Provide that a kind of system is succinct, method is simple, flow is succinct, be easy to implement, sensitivity is high, cost of implementation is low, real-time is good, Gao Ke
By property, high stability, need that space is small, flexibility strong, do not influence to detect performance, function are easy to expand, have a wide range of application one
Ambient noise weakens method in planting magneticencephalogram detection, substantially avoids the deficiency of first technology.
Claims (5)
1. ambient noise weakens system in a kind of magneticencephalogram detection, including wears flexible substrate（1）, array of magnetic sensors layer（2）、
Wearable magnetic field sensor neck ring（4）, it is characterised in that：It is described to wear flexible substrate（1）Outside is provided with array of magnetic sensors
Layer（2）, array of magnetic sensors layer（2）By brain array of magnetic field（201）With external magnetic field sensor array（202）Constitute, brain
Array of magnetic field（201）With external magnetic field sensor array（202）It is distributed in two hemisphere of brain or so, array of magnetic sensors
Layer（1）Outside is provided with magnetic masking layer（3）；The wearable magnetic field sensor neck ring（4）It is arranged on neck, wearable magnetic
Field sensor neck ring（4）By brain magnetic field sensor annular array（401）, external magnetic field sensor annular array（402）Constitute；It is described
Brain array of magnetic field（201）By head brain magnetic field analysis module（5）With the external magnetic field sensor array（202）Pass through
Head external magnetic field analysis module（6）Magneticencephalogram synthesis module is connected respectively（9）；The brain magnetic field sensor annular array（401）
By neck brain magnetic field analysis module（7）With the external magnetic field sensor annular array（402）Mould is analyzed by neck external magnetic field
Block（8）Magneticencephalogram synthesis module is connected respectively（9）.
2. ambient noise weakens system in magneticencephalogram detection according to claim 1, it is characterised in that：Magnetic field sensor is
Alkali metal atom magnetic field sensor.
3. ambient noise weakens the noise attenuation method of system in the magneticencephalogram detection described in a kind of application claim 1 or 2, its
It is characterised by：First, brain array of magnetic field（201）Detect brain Magnetic Field and be transmitted to head brain magnetic field analysis module（5）
It is analyzed, external magnetic field sensor array（202）Head external magnetic field information is transmitted to head external magnetic field analysis module（6）Made an uproar
Sound characteristicses are analyzed；Meanwhile, wearable magnetic field sensor neck ring（4）Brain magnetic field sensor annular array（401）By neck
Region brain Magnetic Field is transmitted to neck brain magnetic field analysis module（7）It is analyzed, wearable magnetic field sensor neck ring（4）Outer magnetic
Neck region external magnetic field information is transmitted to neck external magnetic field analysis module by field sensor annular array (402)（8）Carry out outer
Portion's noise analysis；Then, head brain magnetic field analysis module（5）, neck brain magnetic field analysis module（7）, head external magnetic field analysis mould
Block（6）, neck external magnetic field analysis module（8）Magnetic Field is transferred to magneticencephalogram synthesis module（9）, magneticencephalogram synthesis module
（9）Brain Magnetic Field is merged, noise analysis is carried out to outside Magnetic Field, obtained reference noise background signal, merged
Brain Magnetic Field subtracts reference noise background signal, realizes that the ambient noise in magneticencephalogram detection is slackened, and obtains high s/n ratio brain
Magnetic chart.
4. noise attenuation method according to claim 3, it is characterised in that：The head external magnetic field analysis module（6）It is
Based on external magnetic field frequency characteristic, and external magnetic field and the brain magnetic field degree of association, magnetic field carries out signature analysis and intensity to external world
Distribution calculates assessment, obtains the external magnetic field distribution that there is interference to brain magnetic field.
5. noise attenuation method according to claim 3, it is characterised in that：The neck external magnetic field analysis module（8）It is
Based on external magnetic field frequency characteristic, and external magnetic field and the brain magnetic field degree of association, magnetic field carries out signature analysis and intensity to external world
Distribution calculates assessment, obtains the neck area external magnetic field distribution that there is interference to brain magnetic field.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107562188A (en) * | 2017-07-17 | 2018-01-09 | 北京大学 | Brain machine interface system and its application method based on atom magnetometer |
| CN109009065A (en) * | 2018-06-05 | 2018-12-18 | 上海理工大学 | Brain magnetic information detection system and method based on TMR weak magnetic sensor array |
| CN109691997A (en) * | 2019-01-14 | 2019-04-30 | 苏州融康信息科技有限公司 | The detection method in brain detector for magnetic field and brain magnetic field |
| CN110477898A (en) * | 2019-08-28 | 2019-11-22 | 张海军 | A kind of wearable medical monitoring device and system based on weak magnetic detection |
| CN111281370A (en) * | 2020-02-19 | 2020-06-16 | 北京航空航天大学 | Gradiometer configuration type magnetoencephalography system based on SERF atomic magnetometer |
| CN111543949A (en) * | 2020-05-13 | 2020-08-18 | 北京航空航天大学 | Child ASD diagnosis device based on magnetoencephalogram and electroencephalogram |
| CN112515679A (en) * | 2020-12-01 | 2021-03-19 | 北京昆迈医疗科技有限公司 | Unshielded magnetocardiogram device |
| CN113171098A (en) * | 2021-05-06 | 2021-07-27 | 中国科学院上海光学精密机械研究所 | Detection device and detection method for magnetoencephalography signals in cerebral oscillation |
| CN115018018A (en) * | 2022-08-05 | 2022-09-06 | 北京航空航天大学杭州创新研究院 | Double spatial filtering method for inhibiting background noise |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107562188A (en) * | 2017-07-17 | 2018-01-09 | 北京大学 | Brain machine interface system and its application method based on atom magnetometer |
| CN107562188B (en) * | 2017-07-17 | 2020-08-04 | 北京大学 | Brain-computer interface system based on atomic magnetometer and use method thereof |
| CN109009065A (en) * | 2018-06-05 | 2018-12-18 | 上海理工大学 | Brain magnetic information detection system and method based on TMR weak magnetic sensor array |
| CN109009065B (en) * | 2018-06-05 | 2021-11-19 | 上海理工大学 | Brain magnetic information detection system and method based on TMR weak magnetic sensor array |
| CN109691997A (en) * | 2019-01-14 | 2019-04-30 | 苏州融康信息科技有限公司 | The detection method in brain detector for magnetic field and brain magnetic field |
| CN110477898A (en) * | 2019-08-28 | 2019-11-22 | 张海军 | A kind of wearable medical monitoring device and system based on weak magnetic detection |
| CN111281370A (en) * | 2020-02-19 | 2020-06-16 | 北京航空航天大学 | Gradiometer configuration type magnetoencephalography system based on SERF atomic magnetometer |
| CN111543949A (en) * | 2020-05-13 | 2020-08-18 | 北京航空航天大学 | Child ASD diagnosis device based on magnetoencephalogram and electroencephalogram |
| CN112515679A (en) * | 2020-12-01 | 2021-03-19 | 北京昆迈医疗科技有限公司 | Unshielded magnetocardiogram device |
| CN113171098A (en) * | 2021-05-06 | 2021-07-27 | 中国科学院上海光学精密机械研究所 | Detection device and detection method for magnetoencephalography signals in cerebral oscillation |
| CN115018018A (en) * | 2022-08-05 | 2022-09-06 | 北京航空航天大学杭州创新研究院 | Double spatial filtering method for inhibiting background noise |
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