CN106831465A - A kind of method by hydrolyzing refinement beta Alanine in gelatine - Google Patents
A kind of method by hydrolyzing refinement beta Alanine in gelatine Download PDFInfo
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- CN106831465A CN106831465A CN201611233188.XA CN201611233188A CN106831465A CN 106831465 A CN106831465 A CN 106831465A CN 201611233188 A CN201611233188 A CN 201611233188A CN 106831465 A CN106831465 A CN 106831465A
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- Prior art keywords
- oil
- benzene
- alanine
- edible vegetable
- gelatine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/28—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from natural products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
It is a kind of to be related to medicine intermediate production technical field by hydrolyzing the method for refining beta Alanine in gelatine, by bone piece preliminary crushing, then carry out benzene and carry edible vegetable oil, after benzene oil is separated, obtain after edible vegetable oil carries out condensing crystallizing, after frozen drying, milling is i.e. available.The beneficial effects of the invention are as follows：Present invention process flow is succinct, and extraction process is scientific and reasonable, and twice laid is carried out by by animal bone piece, adequately and reasonably integrally extracts its internal beneficial element, obtains high-purity beta Alanine, is used for Medicines, kills two birds with one stone.
Description
Technical field
The present invention relates to medicine intermediate processing technique field, and in particular to a kind of by hydrolyzing refinement Beta-alanine in gelatine
Method.
Background technology
Beta-alanine, white prismatic crystallization is micro- sweet.205 DEG C of fusing point (decomposition), relative density 1.437.It is dissolved in water, slightly soluble
In ethanol, insoluble in ether and acetone.At 25 DEG C, 100ml water dissolvables 55.5g.50% pH value of water solution 6.0-7.3.Its hydrogen
Chloride is white plates or leaflet crystal, 122.5 DEG C of fusing point.Its chlorination platinum salt is yellow platelet, and 210 DEG C of fusing point (divides
Solution), it is mainly used in plating corrosion inhibiter and biochemical reagents, the intermediate calcium pantothenate for preparing the cold smoked plum of chloramphenicol, can be used for
Microbiology and biochemistry etc. are studied, and Beta-alanine purposes is quite varied, but during its processing preparation, cost is of a relatively high,
It is well known that in animal gelatine, there is substantial amounts of Beta-alanine, but not a kind of system, pure method are carried
Collection is taken, therefore the substantial amounts of wasting of resources can be caused, therefore how thoroughly refined the Beta-alanine in gelatine, be current needs
The important topic of research.
The content of the invention：
The technical problems to be solved by the invention are to provide a kind of process simply, and method system science is extracted thorough
The method by hydrolyzing refinement Beta-alanine in gelatine at bottom.
The technical problems to be solved by the invention are realized using following technical scheme：
A kind of method by hydrolyzing refinement Beta-alanine in gelatine, it is characterised in that comprise the following steps：
1) fresh animal bone piece is selected, preliminary crushing is then carried out, is then placed in pot, be watered after boiling, carry out perseverance
Temperature decocts 3-4h, after being then turned on stirring, is sorted；The meat muscle on bone piece surface, soil are attached to for removing to grind off, done
Net bone piece；
2) during the aggregate after step 1 being processed is fitted into and carries oil cauldron, benzene is added, by steam continuous heating, then forms benzene
After aqueous mixtures, after being cooled down, benzene, oil, aqueous mixtures are obtained, are then discharged out wherein water layer, benzene oil pressure is entered to divide in oil tank,
Carry out benzene oil to separate, obtain edible vegetable oil, it is standby；
3) by above-mentioned edible vegetable oil addition edible vegetable oil tank, live (open) steam is passed through in edible vegetable oil tank, oil is heated to 110-120 DEG C,
Sulfuric acid is added, except colloid and impurity in deoiling, after profit is layered completely, water layer is put, oil reservoir is collected, main oil is obtained, it is standby
With；
4) by above-mentioned main oil after normal pressure concentration 3-5h at 100-105 DEG C, then it is concentrated under reduced pressure after 1-2h at 60-65 DEG C,
Concentrate is obtained, it is standby；
5) after above-mentioned concentrate being neutralized into PH5.5-6 using PH nertralizers, then after carrying out deepfreeze desalination, analysis
Go out NaCl crystallizations, after then being filtered, obtain aminosal, it is standby；
6) after being concentrated and then being carried out frozen drying again by the aminosal in above-mentioned steps 5, ground
After mill, you can obtain Beta-alanine；
PH nertralizers are NaOH and its concentration is 15-16% in above-mentioned steps 5；
When carrying out deepfreeze desalination in above-mentioned steps 5, temperature control is 0-2 DEG C；
The beneficial effects of the invention are as follows：Present invention process flow is succinct, and extraction process is scientific and reasonable, by by animal bone piece
Twice laid is carried out, adequately and reasonably its internal beneficial element is integrally extracted, high-purity Beta-alanine is obtained, for medical treatment
Medicine is used, and is killed two birds with one stone.
Specific embodiment
In order that technological means, creation characteristic, reached purpose and effect that the present invention is realized are easy to understand, tie below
Specific embodiment is closed, the present invention is expanded on further.
Embodiment 1
A kind of method by hydrolyzing refinement Beta-alanine in gelatine, comprises the following steps：
1) fresh animal bone piece is selected, preliminary crushing is then carried out, is then placed in pot, be watered after boiling, carry out perseverance
Temperature decocts 3h, after being then turned on stirring, is sorted；The meat muscle on bone piece surface, soil are attached to for removing to grind off, obtain clean
Bone piece；
2) during the aggregate after step 1 being processed is fitted into and carries oil cauldron, benzene is added, by steam continuous heating, then forms benzene
After aqueous mixtures, after being cooled down, benzene, oil, aqueous mixtures are obtained, are then discharged out wherein water layer, benzene oil pressure is entered to divide in oil tank,
Carry out benzene oil to separate, obtain edible vegetable oil, it is standby；
3) by above-mentioned edible vegetable oil addition edible vegetable oil tank, live (open) steam is passed through in edible vegetable oil tank, oil is heated to 110 DEG C, added
Sulfuric acid, except colloid and impurity in deoiling, after profit is layered completely, puts water layer, collects oil reservoir, obtains main oil, standby；
4) by above-mentioned main oil after normal pressure concentration 3h at 100 DEG C, then it is concentrated under reduced pressure after 1h at 60 DEG C, obtains concentrate,
It is standby；
5) after above-mentioned concentrate being neutralized into PH5.5 using PH nertralizers, then after carrying out deepfreeze desalination, separate out
NaCl is crystallized, and after then being filtered, obtains aminosal, standby；
6) after being concentrated and then being carried out frozen drying again by the aminosal in above-mentioned steps 5, ground
After mill, you can obtain Beta-alanine；
Embodiment 2
A kind of method by hydrolyzing refinement Beta-alanine in gelatine, comprises the following steps：
1) fresh animal bone piece is selected, preliminary crushing is then carried out, is then placed in pot, be watered after boiling, carry out perseverance
Temperature decocts 4h, after being then turned on stirring, is sorted；The meat muscle on bone piece surface, soil are attached to for removing to grind off, obtain clean
Bone piece；
2) during the aggregate after step 1 being processed is fitted into and carries oil cauldron, benzene is added, by steam continuous heating, then forms benzene
After aqueous mixtures, after being cooled down, benzene, oil, aqueous mixtures are obtained, are then discharged out wherein water layer, benzene oil pressure is entered to divide in oil tank,
Carry out benzene oil to separate, obtain edible vegetable oil, it is standby；
3) by above-mentioned edible vegetable oil addition edible vegetable oil tank, live (open) steam is passed through in edible vegetable oil tank, oil is heated to 110-120 DEG C,
Sulfuric acid is added, except colloid and impurity in deoiling, after profit is layered completely, water layer is put, oil reservoir is collected, main oil is obtained, it is standby
With；
4) by above-mentioned main oil after normal pressure concentration 5h at 105 DEG C, then it is concentrated under reduced pressure after 2h at 65 DEG C, obtains concentrate,
It is standby；
5) after above-mentioned concentrate being neutralized into PH5.6 using PH nertralizers, then after carrying out deepfreeze desalination, separate out
NaCl is crystallized, and after then being filtered, obtains aminosal, standby；
6) after being concentrated and then being carried out frozen drying again by the aminosal in above-mentioned steps 5, ground
After mill, you can obtain Beta-alanine；
General principle of the invention and principal character and advantages of the present invention has been shown and described above.The technology of the industry
Personnel it should be appreciated that the present invention is not limited to the above embodiments, simply explanation described in above-described embodiment and specification this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appending claims and its
Equivalent thereof.
Claims (3)
1. it is a kind of by hydrolyzing the method for refining Beta-alanine in gelatine, it is characterised in that to comprise the following steps：
1) fresh animal bone piece is selected, preliminary crushing is then carried out, is then placed in pot, be watered after boiling, carried out constant temperature and decoct
3-4h is boiled, after being then turned on stirring, is sorted；
2) during the aggregate after step 1 being processed is fitted into and carries oil cauldron, benzene is added, by steam continuous heating, then forms benzene water and mix
After compound, after being cooled down, benzene, oil, aqueous mixtures are obtained, be then discharged out wherein water layer, benzene oil pressure is entered to divide in oil tank, carried out
Benzene oil is separated, and obtains edible vegetable oil, standby；
3) by above-mentioned edible vegetable oil addition edible vegetable oil tank, live (open) steam is passed through in edible vegetable oil tank, oil is heated to 110-120 DEG C, added
Sulfuric acid, except colloid and impurity in deoiling, after profit is layered completely, puts water layer, collects oil reservoir, obtains main oil, standby；
4) by above-mentioned main oil after normal pressure concentration 3-5h at 100-105 DEG C, then it is concentrated under reduced pressure after 1-2h at 60-65 DEG C, is obtained
Concentrate, it is standby；
5) after above-mentioned concentrate being neutralized into PH5.5-6 using PH nertralizers, then after carrying out deepfreeze desalination, separate out
NaCl is crystallized, and after then being filtered, obtains aminosal, standby；
6) after being concentrated and then being carried out frozen drying again by the aminosal in above-mentioned steps 5, it is ground
Afterwards, you can obtain Beta-alanine.
2. according to claim 1 a kind of by hydrolyzing the method for refining Beta-alanine in gelatine, it is characterised in that：The step
PH nertralizers are NaOH and its concentration is 15-16% in rapid 5.
3. according to claim 1 a kind of by hydrolyzing the method for refining Beta-alanine in gelatine, it is characterised in that：The step
When carrying out deepfreeze desalination in rapid 5, temperature control is 0-2 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611233188.XA CN106831465A (en) | 2016-12-28 | 2016-12-28 | A kind of method by hydrolyzing refinement beta Alanine in gelatine |
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|---|---|---|---|
| CN201611233188.XA CN106831465A (en) | 2016-12-28 | 2016-12-28 | A kind of method by hydrolyzing refinement beta Alanine in gelatine |
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| CN106831465A true CN106831465A (en) | 2017-06-13 |
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| CN201611233188.XA Pending CN106831465A (en) | 2016-12-28 | 2016-12-28 | A kind of method by hydrolyzing refinement beta Alanine in gelatine |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6231915B2 (en) * | 1983-05-25 | 1987-07-10 | Degussa | |
| JPS6328061B2 (en) * | 1980-03-18 | 1988-06-07 | Mitsubishi Petrochemical Co | |
| JPS6422848A (en) * | 1987-07-15 | 1989-01-25 | Sumitomo Chemical Co | Separation and purification of amino acid |
| CN1173487A (en) * | 1996-10-08 | 1998-02-18 | 马子鳌 | Method for extracting amino acid needed by human body and amino acid products series |
| CN1515543A (en) * | 2002-10-10 | 2004-07-28 | 黄洪锐 | Method for separating 14 amino acids by utilizing active carbon adsorption column and adopting once-through method |
| CN1757633A (en) * | 2005-10-28 | 2006-04-12 | 陈贵卿 | Method for organic acid hydrolytic producing amino-acid |
| CN103787939A (en) * | 2014-03-12 | 2014-05-14 | 广州博采生物科技有限公司 | Method and device of separating and extracting amino acid products from protein hydrolysates |
| US20140148607A1 (en) * | 2011-07-19 | 2014-05-29 | Arkema France | Process for Synthesizing Omega-Functionalized Acids from Fatty Acids or Fatty Esters |
-
2016
- 2016-12-28 CN CN201611233188.XA patent/CN106831465A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6328061B2 (en) * | 1980-03-18 | 1988-06-07 | Mitsubishi Petrochemical Co | |
| JPS6231915B2 (en) * | 1983-05-25 | 1987-07-10 | Degussa | |
| JPS6422848A (en) * | 1987-07-15 | 1989-01-25 | Sumitomo Chemical Co | Separation and purification of amino acid |
| CN1173487A (en) * | 1996-10-08 | 1998-02-18 | 马子鳌 | Method for extracting amino acid needed by human body and amino acid products series |
| CN1515543A (en) * | 2002-10-10 | 2004-07-28 | 黄洪锐 | Method for separating 14 amino acids by utilizing active carbon adsorption column and adopting once-through method |
| CN1757633A (en) * | 2005-10-28 | 2006-04-12 | 陈贵卿 | Method for organic acid hydrolytic producing amino-acid |
| US20140148607A1 (en) * | 2011-07-19 | 2014-05-29 | Arkema France | Process for Synthesizing Omega-Functionalized Acids from Fatty Acids or Fatty Esters |
| CN103787939A (en) * | 2014-03-12 | 2014-05-14 | 广州博采生物科技有限公司 | Method and device of separating and extracting amino acid products from protein hydrolysates |
Non-Patent Citations (1)
| Title |
|---|
| 施强等: "从骨胶中提取L-羟基脯氨酸和L-脯氨酸", 《食品科学》 * |
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Application publication date: 20170613 |