CN106822536A - It is a kind of to treat Chinese medicine composition of toxplasmosis in pigs and preparation method and application - Google Patents
It is a kind of to treat Chinese medicine composition of toxplasmosis in pigs and preparation method and application Download PDFInfo
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- CN106822536A CN106822536A CN201710174815.5A CN201710174815A CN106822536A CN 106822536 A CN106822536 A CN 106822536A CN 201710174815 A CN201710174815 A CN 201710174815A CN 106822536 A CN106822536 A CN 106822536A
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Abstract
The present invention is a kind of Chinese medicine composition for treating toxplasmosis in pigs, and the Chinese medicine composition includes the raw material of following weight proportion：Inonotus obliquus 15 30；Bi Collettii 15 30；Chinese torreyanut 10 20.Present invention also offers the preparation method of above-mentioned Chinese medicine composition.Present invention also offers application of the above-mentioned Chinese medicine composition in treatment toxplasmosis in pigs is prepared.Using the Chinese prescription with clearing heat and detoxicating, desinsection, spleen benefiting and stimulating the appetite, promoting digestion and removing indigestion, regulation immunity of organisms effect, rationally, low cost can reach the effect treated both principal and secondary aspect of disease to compatibility to Chinese medicine composition of the present invention.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating toxplasmosis in pigs, further relate to
The preparation method and applications of the Chinese medicine composition.
Background technology
Toxplasmosis in pigs is also called toxoplasmosis, is a kind of protozoosis caused by Toxoplasma goodii, by mouth, eye, nose,
The approach such as respiratory tract, enteron aisle and skin invade pig body, are characterized with hyperpyrexia, breathing and nervous symptoms and breeding difficulty, and pig breaks out
The pig on whole pig farm can be made to fall ill during toxoplasmosis, the death rate is up to more than 60%.Wherein, piglet morbidity is particularly acute, many
In acute process, sick pig is given up eat suddenly, and body temperature is increased to more than 41 DEG C, is short of breath, in abdomen formula or the clear nose of dog sitting posture respiratory flow
There is serosity or purulent secretion in tears intraocular.Often there is constipation, in pelletized form excrement, outer attached mucus, some affected pigs are after morbidity
Phase has loose bowels urine in crocus, and minority is vomitted.Affected pig spirit is depressed, significantly weak.There is conjunctival congestion in a few days after morbidity, has
Gum, some four limbs and whole-body muscle are stiff, unstable on foot, or even dysstasia, chronic sick pig depauperation, diarrhea, with
Blindness and nervous symptoms.With the development of the state of an illness, on the inside of earflap, nose, lower limb, stock, lower abdomen etc. occur purplish-red macula or
Between have a dot bleeding, some sick pigs form silly skin on auricular concha, and have sharp ears occurs dry necrosis, finally because breathing is the devil and body
Temperature drastically decline and it is dead, pregnant pig often occur miscarry or stillborn foetus.
At present, generally using sulfa drugs carries out prevention and treatment toxplasmosis in pigs, and sulfa drugs is easily produced
Medicament residue, very big threat is caused to pig industry.
The content of the invention
The technical problems to be solved by the invention are directed to the deficiencies in the prior art, there is provided one kind formula advantages of simple, treatment
The Chinese medicine composition of the treatment toxplasmosis in pigs imitated.
Another technical problem to be solved by this invention there is provided the Chinese medicine for the treatment of toxplasmosis in pigs as described above
The preparation method of compositions.
Present invention also offers application of the above-mentioned Chinese medicine composition in treatment toxplasmosis in pigs is prepared.
The technical problems to be solved by the invention are realized by following technical scheme.The present invention is a kind for the treatment of
The Chinese medicine composition of toxplasmosis in pigs, is characterized in, the Chinese medicine composition includes the raw material of following weight proportion：Inonotus obliquus
15-30；Bi Collettii 15-30；Chinese torreyanut 10-20.
In the Chinese medicine composition technical scheme of above-described treatment toxplasmosis in pigs, the weight proportion of each raw material is：Birch
Brown pore fungi 20；Bi Collettii 20；Chinese torreyanut 10.
In the Chinese medicine composition technical scheme of above-described treatment toxplasmosis in pigs：The Chinese medicine composition also includes following
The raw material of weight proportion：Pumpkin seeds 5-10；Radix bupleuri 8-12；Radix Glycyrrhizae 10-15.It is further preferred that the weight of described pumpkin seeds
Match is 8；The weight proportion of described radix bupleuri is 9；The weight proportion of described Radix Glycyrrhizae is 10.
In the Chinese medicine composition technical scheme of above-described treatment toxplasmosis in pigs：The Chinese medicine composition also includes following
The raw material of weight proportion：Butterflybush flower 2-6.It is further preferred that the weight proportion of described butterflybush flower is 3.
In the Chinese medicine composition technical scheme of above-described treatment toxplasmosis in pigs：The Chinese medicine composition also includes following
The raw material of weight proportion：Chinese violet 4-9；Honeysuckle 6-10；Eucalyptus robusta 8-12；Malt 5-10；Dried orange peel 2-5.Further preferably
Ground, the weight proportion of described Chinese violet is 6.5；The weight proportion of described honeysuckle is 8.5；The weight of described eucalyptus robusta
Amount proportioning is 12；The weight proportion of described malt is 10；The weight proportion of described dried orange peel is 3.
Present invention also offers the preparation method of the Chinese medicine composition described in above technical scheme, it is characterized in, its step
It is as follows：
（1）Each raw material is weighed by the weight proportion, is crushed or is shredded, mixed, obtain mixed material medicine；
（2）To mixed material medicine 8-10 times of water measured of gross weight is added in mixed material medicine, 4-6h is soaked, intense fire is boiled to boiling,
20-30min is maintained after boiling, then with 0.5-1h is cooked by slow fire, is filtered, obtain decocting liquid and filter residue, filter residue is again with 3-6 times of weight
Decocting is boiled 2-3 times, each 2-3h, filtering, discards filter residue, merges each decocting liquid, is concentrated under reduced pressure, and obtains relative at 60-65 DEG C
Density is the medicinal extract of 1.1-1.2；
（3）To step（2）80-90% ethanol is added in the medicinal extract for obtaining, 60-75% is reached to determining alcohol, stirred, it is quiet
Precipitation is put, is filtered, filtrate decompression concentration removes ethanol, it is the concentrate of 1.25-1.3 to obtain the relative density at 60-65 DEG C；
（4）By step（3）The concentrate for obtaining is made powder, granule, oral liquid or injection.
Chinese medicine composition of the present invention is applied in the medicine for preparing treatment toxplasmosis in pigs.
The property of medicine of Chinese medicine material of the present invention is as follows：
Inonotus obliquus（Inonotus obliquus）：Also CHAGA is, it is among the people as the medicinal true for the treatment of disease in Russia
Bacterium, belongs to pure Chinese medicine, and long-term zoopery and clinical trial shows to use Inonotus obliquus without any side effects, but also has
There are good anticancer, hypoglycemic, Immunestimulatory effect, body immunity can be strengthened, additionally it is possible to effectively suppress infective virus, it is right
Hepatitis, gastritis, duodenal ulcer, ephritis have obvious therapeutic action, and have treatment to vomiting, diarrhoea, gastrointestinal dysfunction
Effect, in addition, research confirms that Fuscoporia obliqua polysaccharide has preferable resisting toxoplasmosis activity.
Bi Collettii：It is sweet, put down, liver, kidney, stomach are included into, turbid, effect of wind expelling stagnation removing is gone with dampness removing, cure mainly stranguria with turbid discharge leukorrhea, waist
Knee numbness pain, damp and hot sore, wind-dispelling, dampness removing controls rheumatoid arthritis stubborn, lumbocrural pain, difficult urination, stranguria with turbid discharge, seminal emission, damp and hot sore.Bi
Contained Dioscin or dioscorea sapotoxin have insecticidal action in Collettii rhizome, and Dioscin, carat plug woods glucoside are also antimycotic
Effect.Research shows that , Bi Collettii decocting liquids have the effect of resisting toxoplasmosis.
Chinese torreyanut：It is sweet, to put down, return lung, stomach, large intestine channel, with killing insect and eliminating accumulation, moisten the lung and relieve the cough, and the effect for relaxing bowel cures mainly hook
Parasitosis, roundworm disease, abdominal pain due to enterositosis, infantile malnutrition, soap cough, the card such as constipation, pharmacological research its to hookworm, tapeworm, pinworm
Worm has suppression killing effect, and its various fat is discharged to enteron aisle lubricating oil beneficial to polypide.
Pumpkin seeds：It is sweet, put down, return large intestine channel, with insect-expelling function, lower breast is cured mainly, inducing diuresis for removing edema, main tapeworm, roundworm, blood is inhaled
Worm, hookworm, enterobiasis, hemorrhoid.
Radix bupleuri：Hardship, is slightly cold, Return liver, gallbladder channel, with antipyretic, calm, analgesia, anti-inflammatory, controls effect of malaria.
Radix Glycyrrhizae：It is flat, sweet, return 12 warps.With removing toxic substances, eliminating the phlegm, analgesic, spasmolysis so that the pharmacological action such as anticancer.In the traditional Chinese medical science
On, Radix Glycyrrhizae is invigorated the spleen and benefited qi, and moistening lung, emergency removing toxic substances, hundred medicines of mediation are coughed in taste.
Butterflybush flower：It is sweet, it is slightly cold, return liver warp, the effect with heat-clearing nourishing the liver, improving eyesight and anti-inflammatory can improve look unfamiliar screen film, liver
Empty mesh is dark, blurring of vision.
Chinese violet：Bitter, acrid, cold, the thoughts of returning home, Liver Channel, containing the compositions such as glucoside, flavonoids, wax, cerinic acid and unsaturated acids, tool
Have clearing heat and detoxicating, the effect of cool blood detumescence.
Honeysuckle：It is sweet, tremble with fear, return lung, the heart, stomach, with clearing heat and detoxicating, wind-heat dissipating effect, for carbuncle swells furunculosis, larynx
Numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.Honeysuckle antibacterial range is wide, blue to various gram-positive bacterias and leather
Family name's negative bacterium has inhibitory action, and has antiendotoxin, enhancing immunologic function, anti-inflammatory, refrigeration function.
Eucalyptus robusta：Micro-pungent, slight bitter, put down, and cure mainly that dispelling wind is antipyretic, and inhibiting bacteria and diminishing inflammation, anti-corrosion is antipruritic, can be used to prevent popular sexuality
Emit, control enteritis, dysentery, filariasis can adjust body's immunity.
Malt：It is sweet, to put down, returns spleen, stomach cure mainly promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling, for dyspepsia, gastral cavity abdomen
Distending pain, spleen eating less.
Dried orange peel：It is bitter, pungent, temperature, return lung, the spleen channel, with regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function, cure mainly poor appetite, abdomen
Bitterly, tripe swollen, diarrhea, productive cough due to phlegm-damp etc..
Compared with prior art, Chinese medicine composition of the present invention is using with clearing heat and detoxicating, desinsection, spleen benefiting and stimulating the appetite, digestion-promoting
The Chinese prescription of product, regulation immunity of organisms effect, rationally, low cost can reach the effect treated both principal and secondary aspect of disease to compatibility.Use
When, can admix in pig feed or added to being injected in pig drinking water or directly, sick pig be treated, treat pig arch
The effect of parasitosis is good, and without obvious toxic-side effects, the excitant to body is small, and avoids and caused in pig body using antibiotic
Medicament residue.Meanwhile, the preparation method of Chinese medicine composition of the present invention is easy to operate, prepares product quality stabilization, is adapted to
Industrialized production.
Specific embodiment
Concrete technical scheme of the invention described further below, is further understood that in order to those skilled in the art
The present invention, without constituting the limitation to its right.
Embodiment 1, a kind of Chinese medicine composition for treating toxplasmosis in pigs, it is by the Chinese medicine material system of following weight proportion
Into：Inonotus obliquus 15；Bi Collettii 15；Chinese torreyanut 10.
Preparation method：
（1）Each raw material is weighed by the weight proportion, is crushed or is shredded, mixed, obtain mixed material medicine；
（2）To 10 times of water of amount of mixed material medicine gross weight are added in mixed material medicine, 6h is soaked, intense fire is boiled to boiling, boiling
After maintain 30min, then with 1h is cooked by slow fire, filter, obtain decocting liquid and filter residue, filter residue boils 3 times with the decocting of 6 times of weight again, often
Secondary 3h, filtering discards filter residue, merges each decocting liquid, is concentrated under reduced pressure, and obtains the medicinal extract that the relative density at 65 DEG C is 1.2；
（3）To step（2）90% ethanol is added in the medicinal extract for obtaining, 75% is reached to determining alcohol, stirred, it is heavy to stand
Form sediment, filtering, filtrate decompression concentration removes ethanol, obtains the concentrate that the relative density at 65 DEG C is 1.3；
（4）To step（3）Water for injection is added in the concentrate for obtaining, every 1mL crude drug amounts containing 2g are diluted to, filtered, it is filling, go out
Bacterium, obtains final product injection.
Application method：Intramuscular injection, presses this injection of 1kg pigs body weight injection 0.1-0.2mL, 1-2 times on the one every time.
Embodiment 2, a kind of Chinese medicine composition for treating toxplasmosis in pigs, it is by the Chinese medicine material system of following weight proportion
Into：Inonotus obliquus 30；Bi Collettii 30；Chinese torreyanut 20.
Preparation method and application method are with embodiment 1.
Embodiment 3, a kind of Chinese medicine composition for treating toxplasmosis in pigs, it is by the Chinese medicine material system of following weight proportion
Into：Inonotus obliquus 20；Bi Collettii 20；Chinese torreyanut 10.
Preparation method and application method are with embodiment 1.
Embodiment 4, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 1-3 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Pumpkin seeds 5；Radix bupleuri 8；Radix Glycyrrhizae 10.
Preparation method：
（1）Each raw material is weighed by the weight proportion, is crushed or is shredded, mixed, obtain mixed material medicine；
（2）To 9 times of water of amount of mixed material medicine gross weight are added in mixed material medicine, 6h is soaked, intense fire is boiled to boiling, after boiling
30min is maintained, then with being cooked by slow fire 0.5h, filtering obtains decocting liquid and filter residue, filter residue boils 2 times with the decocting of 5 times of weight again, often
Secondary 3h, filtering discards filter residue, merges each decocting liquid, is concentrated under reduced pressure, and obtains the medicinal extract that the relative density at 65 DEG C is 1.15；
（3）To step（2）90% ethanol is added in the medicinal extract for obtaining, 65% is reached to determining alcohol, stirred, it is heavy to stand
Form sediment, filtering, filtrate decompression concentration removes ethanol, obtains the concentrate that the relative density at 65 DEG C is 1.28；
（4）To step（3）After the concentrate spray drying treatment for obtaining, crush, add appropriate amount of starch and dextrin, be well mixed,
Granulation, obtains final product granule.
Application method：Mixed feeding, feed is admixed by the 0.15-0.2% of pig body weight, or adds this granule 1.5g per 1L water, is led to
Cross drinking-water oral.
Embodiment 5, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 1-3 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Pumpkin seeds 10；Radix bupleuri 12；Radix Glycyrrhizae 15.
Preparation method and application method are with embodiment 4.
Embodiment 6, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 1-3 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Pumpkin seeds 8；Radix bupleuri 9；Radix Glycyrrhizae 10.
Preparation method and application method are with embodiment 4.
Embodiment 7, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 4-6 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Butterflybush flower 2.
Preparation method：
（1）Each raw material is weighed by above-mentioned weight proportion, is crushed or is shredded, mixed, obtain mixed material medicine；
（2）To 8 times of water of amount of mixed material medicine gross weight are added in mixed material medicine, 4h is soaked, intense fire is boiled to boiling, after boiling
20min is maintained, then with being cooked by slow fire 0.5h, filtering obtains decocting liquid and filter residue, filter residue boils 2 times with the decocting of 3 times of weight again, often
Secondary 2h, filtering discards filter residue, merges each decocting liquid, is concentrated under reduced pressure, and obtains the medicinal extract that the relative density at 60 DEG C is 1.1；
（3）To step（2）80% ethanol is added in the medicinal extract for obtaining, 60% is reached to determining alcohol, stirred, it is heavy to stand
Form sediment, filtering, filtrate decompression concentration removes ethanol, obtains the concentrate that the relative density at 60 DEG C is 1.25；
（4）To step（3）Pure water is added in the concentrate for obtaining, every 1mL crude drug amounts containing 1g are diluted to, filtered, filling, sterilizing,
Obtain final product oral liquid.
Application method：Mixed drink, this oral liquid 1.5-2mL is added per 1L water, oral by drinking-water.
Embodiment 8, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 4-6 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Butterflybush flower 6.
Preparation method and application method are with embodiment 7.
Embodiment 9, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 4-6 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Butterflybush flower 3.
Preparation method and application method are with embodiment 7.
Embodiment 10, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 7-9 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Chinese violet 4；Honeysuckle 6；Eucalyptus robusta 8；Malt 5；Dried orange peel 2.
Preparation method：
（1）Each raw material is weighed by the weight proportion, is crushed or is shredded, mixed, obtain mixed material medicine；
（2）To 10 times of water of amount of mixed material medicine gross weight are added in mixed material medicine, 5h is soaked, intense fire is boiled to boiling, boiling
After maintain 25min, then with 0.8h is cooked by slow fire, filter, obtain decocting liquid and filter residue, filter residue is boiled 2 times with the decocting of 4 times of weight again,
Each 2.5h, filtering discards filter residue, merges each decocting liquid, is concentrated under reduced pressure, and obtains the medicinal extract that the relative density at 60 DEG C is 1.2；
（3）To step（2）85% ethanol is added in the medicinal extract for obtaining, 70% is reached to determining alcohol, stirred, it is heavy to stand
Form sediment, filtering, filtrate decompression concentration removes ethanol, obtains the concentrate that the relative density at 60 DEG C is 1.25；
（4）To step（3）After the concentrate spray drying treatment for obtaining, crush, add appropriate amount of starch and dextrin, be well mixed,
50 mesh sieves are crossed, powder is obtained final product；
Application method：Mixed feeding, feed is admixed by the 0.15-0.2% of pig body weight.
Embodiment 11, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 7-9 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Chinese violet 9；Honeysuckle 10；Eucalyptus robusta 12；Malt 10；Dried orange peel 5.
Preparation method and application method are with embodiment 10.
Embodiment 12, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 7-9 any one, the Chinese medicine group
The compound also raw material including following weight proportion：Chinese violet 6.5；Honeysuckle 8.5；Eucalyptus robusta 12；Malt 10；Dried orange peel 3.
Preparation method：
（1）Each raw material is weighed by the weight proportion, is crushed or is shredded, mixed, obtain mixed material medicine；
（2）To 8 times of water of amount of mixed material medicine gross weight are added in mixed material medicine, 5.5h is soaked, intense fire is boiled to boiling, boiling
After maintain 25min, then with 1h is cooked by slow fire, filter, obtain decocting liquid and filter residue, filter residue boils 2 times with the decocting of 3 times of weight again, often
Secondary 2.5h, filtering discards filter residue, merges each decocting liquid, is concentrated under reduced pressure, and obtains the medicinal extract that the relative density at 60 DEG C is 1.2；
（3）To step（2）85% ethanol is added in the medicinal extract for obtaining, 75% is reached to determining alcohol, stirred, it is heavy to stand
Form sediment, filtering, filtrate decompression concentration removes ethanol, obtains the concentrate that the relative density at 60 DEG C is 1.3；
（4）To step（3）Water for injection is added in the concentrate for obtaining, every 1mL crude drug amounts containing 1.5g are diluted to, filtered, it is filling,
Sterilizing, obtains final product injection.
Application method：Intramuscular injection, presses this injection of 1kg pigs body weight injection 0.2-0.3mL, 1-2 times on the one every time.
Embodiment 13, experimental example.
First, animal inoculation pvaccination experiment
1st, experimental animal：35 first 40 age in days health Huaihe River pigs, body weight, purchased from Lianyungang Donghai County kind pig farm, is tested in 25-27kg
Animal detects that toxoplasma antibody testing result is feminine gender through clinical examination, brief introduction hemagglutination test.
2nd, trial drug：
Chinese herbs group：The Chinese medicine composition prepared using the embodiment of the present invention 3；
Western medicine group：Using Sulfamonomethoxime Sodium parenteral solution, Jiangsu Nannong Hi-Tech Animal Medicine Co., Ltd.'s production.
3rd, Toxoplasma gondii kind：There is provided by academy of agricultural sciences of Jiangsu Province veterinary institute.
4th, test method：
（1）Packet design：Test pig is randomly divided into 3 groups（Chinese herbs group, western medicine group and infection control group）, Chinese medicine controls
Treatment group and western medicine group every group 15, infect control group 5.
（2）Artificial infection：Every toxoplasma gondii infection of test pig of Chinese herbs group, western medicine group and infection control group is grown
Support body 2.5 × 104-3×104It is individual.Since 4h after infection, measurement body temperature 2 times daily, morning body temperature more than 40 DEG C, afternoon
Body temperature is considered as body temperature rising more than 40.5 DEG C, and it is same day each group body temperature to take each group experiment temperature of pig body average value, is counted with this
Pig heat type, observes pig clinical symptoms daily.12h taps the abdomen microscopy after infection, amount containing worm is counted, before treatment
Index.
（3）Therapeutic test：Infect 48h according to dosage intramuscular injection trial drug, successive administration 5 days, in after treatment 0,1,3,5
It extracts pig ascites 1 time, after the dyeing of Ji's nurse Sa decoration method, with white blood cell count(WBC) legally constituted authority meter ascites quantity containing trophozoite（Individual/
mL）.Wherein, Chinese herbs group Chinese medicine composition intramuscular injection of the present invention, per kilogram of body weight 0.2mL, an intramuscular injection, daily 1
It is secondary；Western medicine group is injected with Sulfamonomethoxime Sodium parenteral solution head, is used to specifications；Infection control group, without
Medicine.Test pig takes group feeding, free water.
4th, result of the test：
Pig to infecting toxplasmosis in pigs, gives Chinese medicine composition of the present invention and Sulfamonomethoxime Sodium parenteral solution enters respectively
Row treatment.Compared with control group, by observing the clinical symptoms of sick pig, it is found that the sick pig clinical symptoms of Chinese herbs group subtract rapidly
It is light and gradually fully recover, and this group of pig recovers normal diet after 3 days in medication.The results are shown in Table 1.
2nd, clinical test
1st, experimental animal：There is certain pig farm of toxplasmosis in pigs in Lianyungang Donghai County, illness rate is up to more than 60%, mainly faces
Bed shows as body temperature rising, and cough and asthma is hard and dry, poor appetite or useless exhausted.The ill pig 55 made a definite diagnosis is randomly selected,
As test pig.
2nd, packet design：
Test pig is randomly divided into 6 groups, including Chinese herbs group 1, Chinese herbs group 2, Chinese herbs group 3, Chinese herbs group 4,
Western medicine group and blank control group, wherein, Chinese herbs group 1, Chinese herbs group 2, Chinese herbs group 3, Chinese herbs group 4,
Western medicine group every group 10, blank control group 5.
3rd, therapeutic test：
Chinese herbs group 1：The Chinese medicine composition prepared using the embodiment of the present invention 3, intramuscular injection presses 1kg pig bodies every time
Re-injection penetrates 0.2mL, an intramuscular injection, 1 times a day, untill healing；
Chinese herbs group 2：The Chinese medicine composition prepared using the embodiment of the present invention 6, feed is admixed by the 0.2% of pig body weight,
Untill healing；
Chinese herbs group 3：The Chinese medicine composition prepared using the embodiment of the present invention 9,2mL is added per 1L water, by drinking-water
Orally, untill healing；
Chinese herbs group 4：The Chinese medicine composition prepared using the embodiment of the present invention 12, intramuscular injection presses 1kg pig bodies every time
Re-injection penetrates 0.2mL, an intramuscular injection, 1 times a day, untill healing；
Western medicine group：With Sulfamonomethoxime Sodium parenteral solution intramuscular injection, use to specifications, untill healing；
Blank control group：Not medication.
Test pig is fed amount and slightly has clout as degree, free water in feed trough after having enough every time.
4th, experimental result：
（1）Dead pig quantity, calculates the death rate during statistics treatment；
（2）Recover normal according to body temperature, spirit, appetite after sick pig medication, no longer occur body temperature raise, cough, skin it is blue
Etc. clinical symptoms, cure rate is calculated.Treatment results are shown in Table 1.
The result of the test of the traditional Chinese medicine composition for treating toxplasmosis in pigs of the present invention of table 1.
From experimental result, Chinese medicine composition of the present invention has preferable therapeutic effect to toxplasmosis in pigs, and with tradition
Compared for treating the Western medicine of toxplasmosis in pigs, its mean treatment number of days is shorter.
3rd, model case
300 bull pork pigs are educated on Lianyungang Donghai County pig farm, and at the beginning of 2 months 2017, swinery sudden onset has 20 pig spirit
Depressed, poor appetite, astasia, body temperature, at 40-41 DEG C, are toxplasmosis in pigs through Disease Diagnosis of Veterinary.Using the embodiment of the present invention
12 injection is treated to sick pig, presses within the 1st day 1kg pigs body weight injection 0.3mL, and 1 times a day, after medication, sick pig body temperature is extensive
It is multiple normal, slightly take food；Press within 2nd day 1kg pigs body weight injection 0.2mL, 1 times a day, after medication, sick pig can normal stand, in eye point
Secretion is significantly reduced, and mental restoration is normal, and is actively searched for food；Press within 3rd day 1kg pigs body weight injection 0.2mL, 1 times a day, medication
Afterwards, sick pig is all fully recovered.
Claims (10)
1. a kind of Chinese medicine composition for treating toxplasmosis in pigs, it is characterised in that the Chinese medicine composition includes following weight proportion
Raw material：Inonotus obliquus 15-30；Bi Collettii 15-30；Chinese torreyanut 10-20.
2. Chinese medicine composition according to claim 1, it is characterised in that the weight proportion of each raw material is：Inonotus obliquus 20；
Bi Collettii 20；Chinese torreyanut 10.
3. Chinese medicine composition according to claim 1 and 2, it is characterised in that the Chinese medicine composition also includes following weight
The raw material of proportioning：Pumpkin seeds 5-10；Radix bupleuri 8-12；Radix Glycyrrhizae 10-15.
4. Chinese medicine composition according to claim 3, it is characterised in that the weight proportion of described pumpkin seeds is 8；It is described
Radix bupleuri weight proportion be 9；The weight proportion of described Radix Glycyrrhizae is 10.
5. Chinese medicine composition according to claim 3, it is characterised in that the Chinese medicine composition also includes following weight proportion
Raw material：Butterflybush flower 2-6.
6. Chinese medicine composition according to claim 5, it is characterised in that the weight proportion of described butterflybush flower is 3.
7. Chinese medicine composition according to claim 5, it is characterised in that the Chinese medicine composition also includes following weight proportion
Raw material：Chinese violet 4-9；Honeysuckle 6-10；Eucalyptus robusta 8-12；Malt 5-10；Dried orange peel 2-5.
8. Chinese medicine composition according to claim 7, it is characterised in that the weight proportion of described Chinese violet is 6.5；
The weight proportion of described honeysuckle is 8.5；The weight proportion of described eucalyptus robusta is 12；The weight proportion of described malt is
10；The weight proportion of described dried orange peel is 3.
9. the preparation method of a kind of Chinese medicine composition as described in claim 1-8 any one, it is characterised in that its step is such as
Under：
（1）Each raw material is weighed by the weight proportion, is crushed or is shredded, mixed, obtain mixed material medicine；
（2）To mixed material medicine 8-10 times of water measured of gross weight is added in mixed material medicine, 4-6h is soaked, intense fire is boiled to boiling,
20-30min is maintained after boiling, then with 0.5-1h is cooked by slow fire, is filtered, obtain decocting liquid and filter residue, filter residue is again with 3-6 times of weight
Decocting is boiled 2-3 times, each 2-3h, filtering, discards filter residue, merges each decocting liquid, is concentrated under reduced pressure, and obtains relative at 60-65 DEG C
Density is the medicinal extract of 1.1-1.2；
（3）To step（2）80-90% ethanol is added in the medicinal extract for obtaining, 60-75% is reached to determining alcohol, stirred, it is quiet
Precipitation is put, is filtered, filtrate decompression concentration removes ethanol, it is the concentrate of 1.25-1.3 to obtain the relative density at 60-65 DEG C；
（4）By step（3）The concentrate for obtaining is made powder, granule, oral liquid or injection.
10. a kind of Chinese medicine composition as described in claim 1-8 any one is in the medicine for preparing treatment toxplasmosis in pigs
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| CN110664875A (en) * | 2019-11-01 | 2020-01-10 | 贾立军 | Traditional Chinese medicine formula composition and application thereof |
| CN111135253A (en) * | 2020-01-16 | 2020-05-12 | 珠海汉唐生物科技工程有限公司 | Formula for eliminating toxoplasma gondii parasitism and preparation method of capsules thereof |
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| CN102715354A (en) * | 2012-06-03 | 2012-10-10 | 周剑峰 | Traditional Chinese medicine feed additive for controlling swine toxoplasmosis |
| CN103251741B (en) * | 2013-05-31 | 2014-08-13 | 江苏农牧科技职业学院 | Chinese medicine composition for treating toxoplasmosisinswine, and preparation method and application thereof |
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| 万红娇等: "中药配伍治疗急性弓形虫病的研究", 《江西中医学院学报》 * |
| 于朝云等: "中草药抗弓形虫作用机制的研究进展", 《中国血吸虫病防治杂志》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110664875A (en) * | 2019-11-01 | 2020-01-10 | 贾立军 | Traditional Chinese medicine formula composition and application thereof |
| CN111135253A (en) * | 2020-01-16 | 2020-05-12 | 珠海汉唐生物科技工程有限公司 | Formula for eliminating toxoplasma gondii parasitism and preparation method of capsules thereof |
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