CN106822386A - It is a kind of to treat bleeding gums, the oral care composition of gum pain - Google Patents
It is a kind of to treat bleeding gums, the oral care composition of gum pain Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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Abstract
The present invention relates to a kind of oral care composition for treating bleeding gums, gum pain, it is characterised in that including the following raw material：Paniculate swallowwort, Chinese violet, peppermint, cloves, sword bean, saururus chinensis, hairyvein agrimony, chickweed, strophanthus divaricatus, Radix Glycyrrhizae.Oral care composition of the invention is the external preparation with Chinese medicine as primary raw material, the effect with excellent treatment bleeding gums and gum pain, without any side effects, to mucous membrane of mouth without any stimulation and adverse reaction.
Description
Technical field
The present invention relates to a kind of oral care composition, more particularly to a kind of treat bleeding gums, the oral cavity of gum pain
Care composition, belongs to oral care techniques field.
Background technology
Periodontitis is a kind of common disease and frequently-occurring disease, is the prestige after cancer, cardiovascular and cerebrovascular disease by medical field final conclusion
The third-largest killer of side of body human body health, is also " number one killer " of oral health.The clinical symptoms of periodontitis are mainly showed
For：Gum is red and swollen, bleeding, the not only bleeding when brushing teeth, sometimes when speaking or stinging hard thing also can bleeding, it is even also to have from sending
Blood, gingiva color is dark red, and most patients with periodontitis, all along with the symptom of gingival atrophy, such as treatment can go out not in time
Existing tooth gradually loosens, and severe patient causes loss of tooth.
Periodontitis is directed in the market, and mainly based on the Western medicine of an antiinflammation, that clinically commonly uses at present is anti-
Anaerobic bacteria medicine is metronidazole and Tinidazole.Metronidazole is, with the choice drug compared with early treatment anaerobic infection, to be taken in clinic
Obtain good effect.However as the passage of time, some anaerobic bacterias constantly strengthen the drug resistance of metronidazole, and the medicinal medicine
Time is long, and side effect is big, have impact on its application clinically.And from Chinese herbal medicine extract natural plant active component due to
Have the advantages that the Western medicine such as safety, natural is incomparable, and turn into the focus in market.
The content of the invention
The deficiency that the present invention exists for the medicine that periodontitis is treated on existing market, there is provided one kind treat bleeding gums,
The oral care composition of gum pain.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：
It is a kind of to treat bleeding gums, the oral care composition of gum pain, it is characterised in that including the following raw material：Slowly
Minister in ancient times long, Chinese violet, peppermint, cloves, sword bean, saururus chinensis, hairyvein agrimony, chickweed, strophanthus divaricatus, Radix Glycyrrhizae.
Including the following raw material further, by weight,：Paniculate swallowwort 15-30 parts, Chinese violet 5-15 parts, peppermint 5-15
Part, cloves 5-15 parts, sword bean 10-20 parts, saururus chinensis 10-20 parts, hairyvein agrimony 10-20 parts, chickweed 10-20 parts, strophanthus divaricatus 10-20
Part, Radix Glycyrrhizae 3-10 parts.
Including the following raw material further, by weight,：20 parts of paniculate swallowwort, 10 parts of Chinese violet, 10 parts of peppermint, cloves
10 parts, 10 parts of sword bean, 15 parts of saururus chinensis, 15 parts of hairyvein agrimony, 15 parts of chickweed, 15 parts of strophanthus divaricatus, 5 parts of Radix Glycyrrhizae.
The property of each raw material and effect are as follows in oral care composition of the present invention：
Paniculate swallowwort：It is pungent, temperature.Return liver, stomach.It is each for arthralgia pain due to rheumatism, pain in the back, traumatic injury pain, abdominal pain, toothache etc.
Plant pain.
Chinese violet：Bitter, acrid, cold are nontoxic.The thoughts of returning home, Liver Channel.Can be used as medicine its clearing heat and detoxicating cool blood detumescence of mildly bitter flavor cold in nature.It is main
Control jaundice, dysentery, mastitis, red eye, swell pain, pharyngitis external application and control traumatic injury, carbuncle swells, venomous snake bite etc..
Peppermint：It is pungent, it is cool.Enter lung channel, Liver Channel.There are dispelling wind and heat from the body, head clearing, relieving sore-throat promoting eruption, soothing the liver promoting the circulation of qi.Cure mainly：Dredge
Wind, radiate, ward off dirty, removing toxic substances, affection of exogenous wind-heat, headache, abscess of throat, food stagnation inflatable, aphtha, toothache, sore scabies, urticaria, warm disease at the beginning of
Rise, rubella itch, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.
Cloves：It is pungent, temperature.Returns spleen, stomach, lung, kidney channel.Middle benefit gas drop is inverse, tonifies the kidney and support yang.For deficiency-cold in spleen and stomach, hiccup vomiting, food
It is few to vomit and diarrhoea, trusted subordinate's crymodynia.
Sword bean：It is sweet, temperature.Return stomach, kidney channel.Middle benefit gas, lower gas, only oh.For cold of insufficiency type hiccup, vomiting.
Saururus chinensis：It is sweet, pungent, tremble with fear.Return lung, bladder warp.Inducing diuresis to remove edema, it is clearing heat and detoxicating.For oedema, difficult urination is drenched
Drench puckery pain, under band；Control sore swollen toxin, eczema outward.
Hairyvein agrimony：It is bitter, sweet, puckery, it is slightly cold.Return lung, liver, stomach.Cure mainly astringing to arrest bleeding, detumescence and promoting granulation.For spitting blood, tell
Blood, traumatism and bleeding, sore swollen toxin, chapped skin.
Chickweed：Mildly bitter flavor, sweet, acid, it is cool in nature.Return liver；Large intestine channel.It is clearing heat and detoxicating, blood-activating analgetic.For enteritis, dysentery, liver
Inflammation, appendicitis, postpartum blood stasis stomachache, uterine contractile bitterly, is had a toothache, traumatic injury, sore swollen toxin.
Strophanthus divaricatus：It is sweet, pungent, puckery, tremble with fear.Attach to the lung and stomach meridians.Hygroscopic, myogenic, sore, hemostasis.Control unhealing ulcer, eczema outward
Itch, scald, traumatism and bleeding.
Radix Glycyrrhizae：It is sweet, put down.The thoughts of returning home, spleen, lung, stomach.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain reconciles
All medicines.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus are alleviated
It is drug toxicity, strong.
The collaboration compatibility effect of each material is as follows in oral care composition of the invention：
Paniculate swallowwort anti-inflammatory analgetic, the clear bright fire having a surplus of sun is cloudy without damaging, therefore is monarch drug in a prescription.Chinese violet, chickweed, peppermint cool blood
Detumescence, to help swelling and pain relieving, hairyvein agrimony cooling blood and hemostasis, saururus chinensis is clearing heat and detoxicating, is altogether minister.Cloves, sword bean, strophanthus divaricatus are assistant
Medicine, cloves makes monarch drug in a prescription excessively not cold and cool, sword bean warming spleen and stomach for dispelling cold, the hemostasis of strophanthus divaricatus sore；Radix Glycyrrhizae is to make, in sweet mitigation, coordinating the drug actions of a prescription.
All medicines share, controls suitable clearing stomach and cooling blood.
Oral care composition of the invention can be used following method to be prepared：
(1) each bulk drug is weighed respectively according to consumption；
(2) paniculate swallowwort：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 1.0-3.0 hours；
(3) Chinese violet：Decocting 1-3 times, it is each 1.0-3.0 hours；
(4) peppermint, cloves：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 2-4 hours；
(5) sword bean：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 1.0-3.0 hours；
(6) saururus chinensis：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 2.0-4.0 hours；
(7) hairyvein agrimony：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 1.0-3.0 hours；
(8) chickweed：Decocting 1-3 times, it is each 1.5-3.0 hours；
(9) strophanthus divaricatus：Decocting 1-3 times, it is each 1.5-3.0 hours；
(10) Radix Glycyrrhizae：Decocting 1-3 times, it is each 1.5-3.0 hours；
(11) by obtained by step (2)-(10) extract mix, can with various assistant agents, routinely preparation method prepare
Various skin-protection products, such as toothpaste, tooth powder, mouth spray, mouthwash.
The beneficial effects of the invention are as follows：
Oral care composition of the invention is the external preparation with Chinese medicine as primary raw material, with excellent treatment gum
Bleeding and the effect of gum pain, it is without any side effects, to mucous membrane of mouth without any stimulation and adverse reaction.
Specific embodiment
Principle of the invention and feature are described below in conjunction with example, example is served only for explaining the present invention, and
It is non-for limiting the scope of the present invention.
Embodiment 1：
It is a kind of to treat bleeding gums, the oral care composition of gum pain, including the following raw material：It is paniculate swallowwort 15g, pale reddish brown
Chinese violet 10g, peppermint 10g, cloves 5g, sword bean 10g, saururus chinensis 15g, hairyvein agrimony 20g, chickweed 10g, strophanthus divaricatus 15g, Radix Glycyrrhizae 10g.
Embodiment 2：
It is a kind of to treat bleeding gums, the oral care composition of gum pain, including the following raw material：It is paniculate swallowwort 25g, pale reddish brown
Chinese violet 5g, peppermint 5g, cloves 10g, sword bean 15g, saururus chinensis 10g, hairyvein agrimony 10g, chickweed 15g, strophanthus divaricatus 10g, Radix Glycyrrhizae 10g.
Embodiment 3：
It is a kind of to treat bleeding gums, the oral care composition of gum pain, including the following raw material：It is paniculate swallowwort 20g, pale reddish brown
Chinese violet 15g, peppermint 15g, cloves 15g, sword bean 20g, saururus chinensis 20g, hairyvein agrimony 15g, chickweed 20g, strophanthus divaricatus 20g, Radix Glycyrrhizae 3g.
Embodiment 4：
It is a kind of to treat bleeding gums, the oral care composition of gum pain, including the following raw material：It is paniculate swallowwort 30g, pale reddish brown
Chinese violet 15g, 15 parts of peppermint, cloves 15g, sword bean 20g, saururus chinensis 20g, hairyvein agrimony 20g, chickweed 20g, strophanthus divaricatus 20g, Radix Glycyrrhizae 7
Part.
The oral care composition of embodiment 1-4 is prepared as follows：
(1) each bulk drug is weighed respectively according to consumption；
(2) paniculate swallowwort：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 1.0-3.0 hours；
(3) Chinese violet：Decocting 1-3 times, it is each 1.0-3.0 hours；
(4) peppermint, cloves：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 2-4 hours；
(5) sword bean：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 1.0-3.0 hours；
(6) saururus chinensis：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 2.0-4.0 hours；
(7) hairyvein agrimony：60-80% ethanol water baths heating and refluxing extraction 1-3 times, it is each 1.0-3.0 hours；
(8) chickweed：Decocting 1-3 times, it is each 1.5-3.0 hours；
(9) strophanthus divaricatus：Decocting 1-3 times, it is each 1.5-3.0 hours；
(10) Radix Glycyrrhizae：Decocting 1-3 times, it is each 1.5-3.0 hours；
(11) by obtained by step (2)-(10) extract mix, can with various assistant agents, routinely preparation method prepare
Various skin-protection products, such as toothpaste, tooth powder, mouth spray, mouthwash, can be used for MC.
Generally, it is sooner or later each using once daily, during use without other dietetic contraindications.
In order to verify the practical effect of oral care composition of the invention, We conducted following experiment：
First, acute oral toxicity test
Experimental basis
According to National Standard of the People's Republic of China, choosing maximum dose 5000mg/kg dosage carries out acute oral toxicity
Experiment.
Experimental animal
SPF grades of healthy mice, female, body weight 18-22kg.
Experimental technique
When the test of 5000mg/kg dosage is carried out, it is only necessary to a step (3 animals).Such as the 1st animal dead, then
Carry out the experiment of 2000mg/kg.Such as the 1st animal survival, then 2 animals after doing.If 3 animals only dead 1, then LD50
More than 5000mg/kg.As 2 animals are all dead, then the experiment of 2000mg/kg dosage levels is done.
Weigh embodiment 1 and prepare compound extract and add distillation water dissolves, as sample solution.4h is spaced in one day to mouse
Oral gavage 3 times, intergal dose reaches 5000mg/kg, first fasting 12h before gavage.Continuous Observation two weeks after gavage, record poisoning
Performance and death condition.
Experimental result
Obvious poisoning symptom is had no after mouse stomach, the state of mind, body weight are normal, 14d is without death for observation.Sample LD50
More than 5000mg/kg.
2nd, analgesic experiment：
Experimental technique
Healthy mice 24 is taken, is weighed, be divided into 3 groups, be administered in the way of gavage respectively：Distilled water (blank group), reality
The solution of example 2 (administration group), Voltarol solution (positive group) are applied, capacity is 0.1ml/10g, and after 30 minutes, every mouse is by abdomen
0.06% acetic acid 0.1m l/10g are injected in chamber, are observed each group in 20 minutes and writhing response number of times are occurred.Mouse writhing reaction performance：
The side belly of intermittence shrinks indent, and back leg is upheld, hips up, while body is distorted.
Experimental result
The writhing method experimental result of table 1.
| Group | Writhing number of times (secondary) | Inhibiting rate (%) |
| Blank group | 38.5 | — |
| Positive group | 22.16 | 42.44 |
| Administration group | 12.50 | 67.53 |
As it can be seen from table 1 administration group mouse writhing number of times is substantially less than blank group, pain inhibiting rate is 67.53%, card
Bright water extract for acetic acid induced mice pain have significantly inhibit effect.
3rd, hemostasis experiment
It is that in the presence of thrombokinase, plasma prothrombin is changed into fibrin ferment and causes blood to coagulate that PT is determined
Solid principle, add excessive tissue factor and calcium ion in tested blood plasma, be quickly generated extrinsic coagulation activation of zymogen thing (i.e.
The blood coagulation first stage), extrinsic coagulation mechanism is to start, and grumeleuse is formed within the regular hour, and blood plasma is formed needed for grumeleuse
Time is PT.
By the primary extract of embodiment 3 (administration group) with quantitative physiological saline solution, add in blood plasma, add fibrin ferment
Original, is mixed, and stopwatch is started immediately, records setting time (s), with physiological saline group as a control group.
| Control group (s) | Administration group (s) | |
| 1 | 18.70 | 10.83 |
| 2 | 27.88 | 23.43 |
| 3 | 20.95 | 14.25 |
| 4 | 26.22 | 22.40 |
| 5 | 19.93 | 14.78 |
| Averagely | 22.14 | 17.14 |
Be can be seen that from above table data, compared with physiological saline group, embodiment 3 has certain rush coagulation function.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all it is of the invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (3)
1. it is a kind of to treat bleeding gums, the oral care composition of gum pain, it is characterised in that including the following raw material：Xu is long
Minister in ancient times, Chinese violet, peppermint, cloves, sword bean, saururus chinensis, hairyvein agrimony, chickweed, strophanthus divaricatus, Radix Glycyrrhizae.
2. oral care composition according to claim 1, it is characterised in that by weight, including the following raw material：Slowly
Long minister in ancient times 15-30 parts, Chinese violet 5-15 parts, peppermint 5-15 parts, cloves 5-15 parts, sword bean 10-20 parts, saururus chinensis 10-20 parts, celestial being
10-20 parts, chickweed 10-20 parts, strophanthus divaricatus 10-20 parts, Radix Glycyrrhizae 3-10 parts of crane grass.
3. oral care composition according to claim 2, it is characterised in that by weight, including the following raw material：Slowly
20 parts of minister in ancient times long, 10 parts of Chinese violet, 10 parts of peppermint, 10 parts of cloves, 10 parts of sword bean, 15 parts of saururus chinensis, 15 parts of hairyvein agrimony, chickweed 15
Part, 15 parts of strophanthus divaricatus, 5 parts of Radix Glycyrrhizae.
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| CN201710176472.6A CN106822386A (en) | 2017-03-23 | 2017-03-23 | It is a kind of to treat bleeding gums, the oral care composition of gum pain |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710176472.6A CN106822386A (en) | 2017-03-23 | 2017-03-23 | It is a kind of to treat bleeding gums, the oral care composition of gum pain |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109364115A (en) * | 2018-12-20 | 2019-02-22 | 扬州倍加洁日化有限公司 | Oral cavity composition and its application containing licorice and Radix Cynanchi Paniculati extract |
| CN109394599A (en) * | 2017-08-15 | 2019-03-01 | 朱丽珍 | A kind of tooth powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080031831A1 (en) * | 2005-10-21 | 2008-02-07 | Technology & Marketing Consulting | Oral anti-calculus compositions and methods of use thereof |
| CN103463270A (en) * | 2013-08-31 | 2013-12-25 | 王雨佳 | Toothache medicine |
| CN104873416A (en) * | 2015-05-12 | 2015-09-02 | 吴永 | Chinese herbal medicine toothpaste and preparation method |
-
2017
- 2017-03-23 CN CN201710176472.6A patent/CN106822386A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080031831A1 (en) * | 2005-10-21 | 2008-02-07 | Technology & Marketing Consulting | Oral anti-calculus compositions and methods of use thereof |
| CN103463270A (en) * | 2013-08-31 | 2013-12-25 | 王雨佳 | Toothache medicine |
| CN104873416A (en) * | 2015-05-12 | 2015-09-02 | 吴永 | Chinese herbal medicine toothpaste and preparation method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394599A (en) * | 2017-08-15 | 2019-03-01 | 朱丽珍 | A kind of tooth powder |
| CN109364115A (en) * | 2018-12-20 | 2019-02-22 | 扬州倍加洁日化有限公司 | Oral cavity composition and its application containing licorice and Radix Cynanchi Paniculati extract |
| CN109364115B (en) * | 2018-12-20 | 2021-06-18 | 扬州倍加洁日化有限公司 | Oral composition containing licorice extract and paniculate swallowwort root extract and application thereof |
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