CN106821862A - A kind of acne-removing composition and preparation method thereof - Google Patents
A kind of acne-removing composition and preparation method thereof Download PDFInfo
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- CN106821862A CN106821862A CN201710176366.8A CN201710176366A CN106821862A CN 106821862 A CN106821862 A CN 106821862A CN 201710176366 A CN201710176366 A CN 201710176366A CN 106821862 A CN106821862 A CN 106821862A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
The invention discloses a kind of acne-removing composition, by weight, including following component：12 parts of salicylic acid；1.2 2.8 parts of arginine；0.1 2 parts of boldo tree leaf extract；0.2 0.5 parts of silver-colored bactericide；1.2 10 parts of other acne-removing compositions；0 90 parts of other base-materials.The present invention is neutralized by by the arginine of the salicylic acid certain content of certain content, compound the boldo tree leaf extract of certain content, and it is aided with silver-colored bactericide as gentle effective anticorrosion and bactericidal agent, other anti-acne compositions are added again in anti-acne base-material, the acne-removing composition for preparing has good acne-removing, and system pH is 5.5 7, close to the pH scopes of human body skin, excitant is small in use, with good mildness.
Description
Technical field
The present invention relates to cosmetic field, more particularly to a kind of acne-removing composition and preparation method thereof.
Background technology
Acne is commonly called as whelk, dark sore, acne, is a kind of infective inflammation of pilosebaceous follicle.Small pox produces inherent former
Because mainly having：（1）Endocrinopathy, smegma is active；（2）The disorder of digestive function：Such as higher fatty acid and high-carbon hydrate
Thing etc.；（3）It is micro- not enough：Such as VitAVitE insufficiency of intake.The transient cause that small pox is produced mainly has：（1）
Skin water oil is uneven, hence it is evident that fuel-displaced, and the lubricant component such as free fatty of cleaning does not trigger scytitis easily in time；（2）Hair
Bag hole keratinization is hyperfunction, blocks pore；（3）Bacterium factors etc..
Product for resolving poxes includes medicine and cosmetics.Anti-acne medicine can clinically be controlled using the therapeutic modality of " oral administration and externally "
The medicine for treating acne is mainly chemicals such as Tretinoin and its derivative species, benzoyl peroxide, sulphur and topical antibiotic
Deng, although effect is relatively good, but using the irritative responses such as allergy, erythema, furfur excessively often occur, is caused to skin
Secondary injury.But acne-eliminating cosmetic can only act on skin using the improvement mode of " external application " with one or more active matter
Skin top layer, by cleaning, it is sterilized, beautify and releive etc. and reach anti-acne effect.Active matter in acne-eliminating cosmetic mainly has：（1）
Suppress sebum secretion agent：Such as zinc oxide, ZnG, PCA zinc；（2）Bactericide：Such as Nano Silver, sulphur；（3）Cutin is shelled
Fall agent：Such as tartaric acid, salicylic acid；（4）Anti-inflammatory is releived agent：Such as dipotassium glycyrrhizinate, allantoin；（5）Natural extract：Such as pellet
The extracts such as ginseng, kuh-seng, Radix Glycyrrhizae, honeysuckle and Cortex Phellodendri.
Although the present acne-eliminating cosmetic containing salicylic acid and above-mentioned some active matters has certain acne-removing, but its
System pH is generally below 5.5, and often the excitant to skin is larger.
The content of the invention
It is contemplated that provide a kind of with good acne-removing, and with the acne-removing composition of good mildness.
Acne-removing composition of the present invention, by weight, including following component：
Salicylic acid 1-2 parts；
Arginine 1.2-2.8 parts；
0.1-2 parts of boldo tree leaf extract；
Silver-colored bactericide 0.2-0.5 parts；
1.2-10 parts of other acne-removing compositions；
0-90 parts of other base-materials.
Wherein, described other acne-removing compositions, including following component：
0.1-2 parts of Cortex Phellodendri extract；
0.1-2 parts of common milfoil extract；
Niacinamide 1-5 parts；
Tea tree ethereal oil 0.0001-0.05 parts；
Wherein, the silver-colored bactericide is selected from the solion of collargol or silver, and the collargol of preferably 3000ppm concentration is water-soluble
One or more in liquid, the silver oxide aqueous solution of 550ppm concentration, the silver oxide aqueous solution of 1000ppm concentration.
Wherein, described other base-materials include water 75-85 weight portions, Carbomer 0.4-1 weight portions, butanediol 3-7 weight portions,
Xanthans 0.05-0.3 weight portions, PAA/sodium acryloyldimethyl taurate copolymers 0-0.8 weight portions, PPG-26- fourths
Alcohol polyethers/Cremophor RH40 0-0.3 weight portions.
Additionally, the invention also discloses the preparation method of above-mentioned acne-removing composition, comprising the following steps：
1）Niacinamide in salicylic acid, arginine, boldo tree leaf extract, silver-colored bactericide, other acne-removing compositions is pressed
Added afterwards completely according to the predissolve of proportioning water and stirred evenly；
2）Tea tree ethereal oil alcohol or solubilizer predissolve in other acne-removing compositions add stir evenly completely afterwards；
3）The Cortex Phellodendri extract of other base-materials and other acne-removing compositions, common milfoil extract is subsequently adding to stir evenly,
Obtain final product.
Compared with prior art, the present invention has the advantages that：
The present invention is neutralized by by the arginine of the salicylic acid certain content of certain content, compounds the boldo tree of certain content
Leaf extract, and it is aided with silver-colored bactericide as gentle effective anticorrosion and bactericidal agent, then add other anti-acne compositions to anti-acne base-material
In, the acne-removing composition for preparing has good acne-removing, and system pH is 5.5-7, close to the pH models of human body skin
Enclose, in addition, arginine sheet is as a kind of gentle NMF, therefore product excitant is small in use, with good temperature
And property.
Specific embodiment
The present invention is further illustrated below by specific embodiment, following examples are the present invention preferably embodiment party
Formula, but embodiments of the present invention are not limited by following embodiments.
The method of testing and evaluation criterion of each performance indications：
The method of testing or evaluation method of acne-removing：
Tested crowd：Face substantially has small pox
Tested number：20-30 people
Position on probation：Face, the position of acne particularly long
Application method：After morning and evening face cleaning, take appropriate given the test agent and be applied to face, acne position particularly long is gently massaged into suction
Receive
Use time：0-4W
Evaluation method：By skin surface part analyzer VISIA CR（Canfield, the U.S.）With face-image analysis software
Image-Pro Plus（Media Cybernetics, Inc.）Photographic analysis is carried out before on probation to subject and after, is counted
Calculate inflammatory papules number per capita or the per capita decrement of warts number；If reducing 80% or more, for excellent；If reducing 50%-
80%, then for good；If reducing less than 50%, for poor.
The method of testing of the pH value of system： GB/T 13531.1
The method of testing or evaluation method of mildness：
Tested crowd：Face substantially has small pox
Tested number：20-30 people
Position on probation：Face, the position of acne particularly long
Application method：After morning and evening face cleaning, take appropriate given the test agent and be applied to face, acne position particularly long is gently massaged into suction
Receive
Evaluation method：
1st, using in sample or using after sample 0-15 minute, if having substantially thorn, heat, itch or the IR such as bitterly, comment
It is obvious stimulation；If having slight thorn, heat, itching or the minor response such as pain, minimal irritation is chosen as；If completely it is stingless, hot, itch or pain
Deng IR, then it is chosen as non-stimulated.（All embodiments and comparative example evaluate excitant using the method）
2nd, patch test method：Device is tried from suitable patch, with closed patch experimental technique, tested material about 0.03ml is applied to
In spot examination device, external application special adhesive tape is pasted on subject back, and tested material is removed after 24 hours, 0.5 after patch is tested,
24th, observation dermoreaction in 48 hours, presses《Cosmetics safety technical specification》（Version in 2015）Middle dermoreaction grade scale record
Its result.（Embodiment 1 and embodiment 6 are also tested in addition to evaluating excitant using above-mentioned first method by patch test method
Card, is as a result without any adverse reaction.）
Embodiment 1-6 and comparative example 1-5：The preparation of acne-removing composition
By the niacinamide in salicylic acid, arginine, boldo tree leaf extract, silver-colored bactericide, other acne-removing compositions according to
The predissolve of proportioning water adds stir evenly completely afterwards；Tea tree ethereal oil alcohol or solubilizer in other acne-removing compositions are pre-dissolved
Solution rear addition completely stirs evenly；It is subsequently adding other base-materials and Cortex Phellodendri extract, the Europe of other acne-removing compositions
Milfoil extract is stirred evenly, and obtains final product acne-removing composition；The performance indications such as acne-removing, the mildness of gained acne-removing composition such as table 1
It is shown.
The each group distribution ratio of the embodiment 1-6 of table 1 and comparative example 1-5 and each testing performance index result
Continued 1
。
Claims (5)
1. a kind of acne-removing composition, it is characterised in that by weight, including following component：
Salicylic acid 1-2 parts；
Arginine 1.2-2.8 parts；
0.1-2 parts of boldo tree leaf extract；
Silver-colored bactericide 0.2-0.5 parts；
1.2-10 parts of other acne-removing compositions；
0-90 parts of other base-materials.
2. acne-removing composition according to claim 1, it is characterised in that described other acne-removing compositions include such as the following group
Point：
0.1-2 parts of Cortex Phellodendri extract；
0.1-2 parts of common milfoil extract；
Niacinamide 1-5 parts；
Tea tree ethereal oil 0.0001-0.05 parts.
3. acne-removing composition according to claim 1, it is characterised in that the silver-colored bactericide be selected from collargol or silver from
The collargol aqueous solution of sub- solution, preferably 3000ppm concentration, the silver oxide aqueous solution of 550ppm concentration, 1000ppm concentration
One or more in the silver oxide aqueous solution.
4. acne-removing composition according to claim 1, it is characterised in that described other base-materials include water 75-85 weight portions,
Carbomer 0.4-1 weight portions, butanediol 3-7 weight portions, xanthans 0.05-0.3 weight portions, PAA/acryloyldimethyl
Taurate Copolymer 0-0.8 weight portions, PPG-26- butylol polyethers/Cremophor RH40 0-0.3 weight portions.
5. the preparation method of a kind of acne-removing composition as described in claim any one of 1-4, it is characterised in that including following step
Suddenly：
1）Niacinamide in salicylic acid, arginine, boldo tree leaf extract, silver-colored bactericide, other acne-removing compositions is pressed
Added afterwards completely according to the predissolve of proportioning water and stirred evenly；
2）Tea tree ethereal oil alcohol or solubilizer predissolve in other acne-removing compositions add stir evenly completely afterwards；
3）The Cortex Phellodendri extract of other base-materials and other acne-removing compositions, common milfoil extract is subsequently adding to stir evenly,
Obtain final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710176366.8A CN106821862A (en) | 2017-03-23 | 2017-03-23 | A kind of acne-removing composition and preparation method thereof |
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| CN201710176366.8A CN106821862A (en) | 2017-03-23 | 2017-03-23 | A kind of acne-removing composition and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107737033A (en) * | 2017-09-27 | 2018-02-27 | 广州市花安堂生物科技有限公司 | A kind of quick anti-acne and anti-acne print composition and preparation method thereof |
| CN112006934A (en) * | 2020-09-04 | 2020-12-01 | 江苏美爱斯化妆品股份有限公司 | Cosmetic compound with mild acne removing effect and application thereof |
| CN115386643A (en) * | 2022-08-18 | 2022-11-25 | 宁波赛缪斯生物科技有限公司 | Method for customizing skin care product based on anti-inflammatory gene and skin care product |
| CN115670998A (en) * | 2022-11-18 | 2023-02-03 | 广州澳莱娜生物科技有限公司 | Acne-removing, oil-controlling and skin-brightening composition and preparation method thereof |
| CN115844796A (en) * | 2022-12-27 | 2023-03-28 | 陕西慧康生物科技有限责任公司 | Water-in-oil composition with acne removal, skin rejuvenation and slow release effects and application |
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2017
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Patent Citations (1)
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| CN105250189A (en) * | 2015-11-24 | 2016-01-20 | 广州市花安堂生物科技有限公司 | Acne treatment essence cream and preparing method thereof |
Non-Patent Citations (2)
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107737033A (en) * | 2017-09-27 | 2018-02-27 | 广州市花安堂生物科技有限公司 | A kind of quick anti-acne and anti-acne print composition and preparation method thereof |
| CN112006934A (en) * | 2020-09-04 | 2020-12-01 | 江苏美爱斯化妆品股份有限公司 | Cosmetic compound with mild acne removing effect and application thereof |
| CN115386643A (en) * | 2022-08-18 | 2022-11-25 | 宁波赛缪斯生物科技有限公司 | Method for customizing skin care product based on anti-inflammatory gene and skin care product |
| CN115670998A (en) * | 2022-11-18 | 2023-02-03 | 广州澳莱娜生物科技有限公司 | Acne-removing, oil-controlling and skin-brightening composition and preparation method thereof |
| CN115844796A (en) * | 2022-12-27 | 2023-03-28 | 陕西慧康生物科技有限责任公司 | Water-in-oil composition with acne removal, skin rejuvenation and slow release effects and application |
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Address after: 511434 No. 13, Liu Wei street, Hualong Town, Panyu District, Guangzhou, Guangdong Applicant after: Hua An Tang biotech Group Co., Ltd. Address before: 511434 No. 13, Liu Wei street, Hualong Town, Panyu District, Guangzhou, Guangdong Applicant before: City flower An Tang bio tech ltd, Guangzhou |
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Application publication date: 20170613 |