CN106821588A - A kind of analgesia cryospray agent with specific aerosol valve Yu actuator - Google Patents
A kind of analgesia cryospray agent with specific aerosol valve Yu actuator Download PDFInfo
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- CN106821588A CN106821588A CN201710103368.4A CN201710103368A CN106821588A CN 106821588 A CN106821588 A CN 106821588A CN 201710103368 A CN201710103368 A CN 201710103368A CN 106821588 A CN106821588 A CN 106821588A
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- agent
- actuator
- aerosol valve
- analgesia
- cryospray
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of analgesia cryospray agent with specific aerosol valve Yu actuator, including following component by mass percentage:80% ~ 95% refrigerant, 3% ~ 19.5% hypertensor and 0.5% ~ 2% wetting agent.0.5% ~ 2% wetting agent is weighed by mass percentage, is passed through micro-precision metering device and poured into inhalator jar, then specific aerosol valve is installed, and seal;By mass percentage to the refrigerant of filling 80% ~ 95% in inhalator jar, then to the hypertensor of filling 3% ~ 19.5% in inhalator jar, then install specific actuator additional and obtain final product.Spray of the invention cooling is held time shorter, and cold burning can be avoided to wait adverse reaction, while can adjust moment cold temperatures, moment cold temperatures are between 10 DEG C~30 DEG C.Product of the invention when spraying can quick break, gone out with pencil spray painting and with certain assault sense, strengthen analgesic effect.
Description
Technical field
The invention belongs to aerosol spray technique field, and in particular to a kind of analgesia with specific aerosol valve and actuator is freezed
Spray, the invention further relates to the preparation method of the aerosol products.
Background technology
Aerosol products refer to be contained in composition sealing to be equiped with the inhalator jar of aerosol valve in jet, in propulsion
The product used by predetermined form ejection under agent pressure.Aerosol products mainly spray form vaporific, foam, powder or micella
Deng wherein vaporific is relatively common ejection form.
Liquid gas moment is in vaporific ejection in inhalator jar, fast due to gasification endothermic effect, a large amount of absorption ambient heats
Fast refrigeration, so as to reach analgesic, anti-effect that is swollen, reducing the cold treatments such as secondary lesion.
Cryospray agent has good analgesia and anastalsis, and this is that domestic and foreign literature is unanimously generally acknowledged, while by one
The strict experiment of series and clinical observation are confirmed.There are various cryospray agent products in the prior art, these aerosols are produced
Product utilize gasifying liquefied gas cooling by heat absorption effect, can produce certain refrigerating effect.It can however not by adjusting refrigerant
Composition make moment cold temperatures control between -10 DEG C~-30 DEG C, it is impossible to realize cooling hold time it is shorter, avoid it is cold burn
The adverse reactions such as wound, it is impossible to realize quickly being sprayed and with certain assault sense to strengthen analgesic effect with pencil mist.Therefore, it is existing
With the presence of the larger limitation of cryospray agent product, influence analgesic effect.
The content of the invention
For the problem that prior art is present, it is an object of the invention to provide a kind of with specific aerosol valve and actuator
Analgesia cryospray agent product and preparation method thereof, solve prior art cryospray product be difficult to control to cold temperatures,
Can not realize quickly being sprayed with pencil mist and hold time uncontrollable with certain assault sense and cooling thus easily cause cold
The problem of adverse reaction such as burn.
To achieve these goals, the present invention uses following technical scheme:
A kind of analgesia cryospray agent with specific aerosol valve Yu actuator, including specific aerosol valve and actuator,
2-4 aperture Φ 0.3mm-0.6mm and metering orifice that is symmetrical or shifting to install are set on the valve rod that the aerosol cuts down, also including spraying
Hole aperture is the integral structure actuator of 0.4mm-1.0mm;Composition includes refrigerant, hypertensor, wetting agent;The refrigeration
Agent is selected from least one in propane, dimethyl ether, normal butane, iso-butane, and its mass content is the 80-95% of composition;It is described
Hypertensor is selected from least one in HFC-134a, HFO-1234ze, nitrogen, carbon dioxide, and its mass content is composition
3-19.5%;The wetting agent is selected from least one in propane diols, ethanol, glycerine, tween, and its mass content is composition
0.5-2%.
The analgesia cryospray agent product with specific aerosol valve Yu actuator, during ejection can quick break, with beam
Shape spray painting goes out and with certain assault sense to significantly increase analgesic effect.Aerosol valve controls the speed that spray products discharge
And impulsive force, key factor is the quantity of metering orifice, aperture and set-up mode on valve rod.Within the specific limits, with stream
Metering-orifice increasing number or aperture increases, rate of release rises, impulsive force is more powerful, symmetrical or shift to install and more have than unilateral setting
Help accelerate flow velocity, play vector superposed effect.Actuator controls the spray configuration and atomizing effect of spray products, crucial
Factor is the aperture of micro- atomizer squit hole, and within the specific limits, squit hole aperture is smaller, and jet angle is smaller, droplet is thinner;
During larger rate of release, integrative-structure actuator should be selected, rather than embedded two pieces knot when spray pressure inside the tank is higher
Structure, prevents micro- atomizer de- by spray.
The analgesia cryospray agent product with specific aerosol valve Yu actuator, moment cold temperatures -10 DEG C~-
30 DEG C, and moment cold temperatures can be by depending on the constituting of refrigerant, that is, selecting in propane, dimethyl ether, normal butane, iso-butane
Kind or it is various and mix in proportion, this moment cold temperatures can in the range of -10 DEG C~-30 DEG C any one temperature section, deviation
No more than 5 DEG C.
The analgesia cryospray agent product with specific aerosol valve Yu actuator, during to make it be ejected into human body skin
Cooling hold time it is shorter, the local temperature of spray close to the level applied before spray is applied after 15 minutes, it is to avoid the cold adverse reaction such as burn,
The mass content of wetting agent is the 0.5-2% of composition in composition, and wetting agent is selected from propane diols, ethanol, glycerine, tween
It is at least one.
The analgesia cryospray agent product with specific aerosol valve Yu actuator, to ensure that product uses week whole
The injection pressure of phase is constant and keeps atomizing effect, and the mass content of hypertensor is the 3-19.5% of composition, choosing in composition
At least one from HFC-134a, HFO-1234ze, nitrogen, carbon dioxide.
The analgesia cryospray agent product with specific aerosol valve Yu actuator, to make its spraying that there is peppermint fragrance
And cooling sensation, its described composition may also include auxiliary agent, and the mass content of the auxiliary agent is the 0.01-0.05% of composition,
Auxiliary agent is selected from the one kind in levorotatory menthol or racemization menthol.
To realize preparation method of the present invention, comprise the following steps:
(1) wetting agent of 0.5-2% is weighed according to mass percent;
(2) by the wetting agent obtained by step (1), measured by predetermined value by micro-precision metering device, poured into inhalator jar,
Then specific aerosol valve is filled, is sealed;
(3) according to mass percent to the refrigerant by predetermined composition that 80-95% is filled in inhalator jar, according still further to quality
Then percentage install the specific actuator additional and obtain final product to the hypertensor that 3-19.5% is filled in inhalator jar.
Preparation method of the present invention is the composition by changing refrigerant, adjusts moment cold temperatures, that is, select propane, diformazan
And mix in proportion, this moment cold temperatures can be in -10 DEG C~-30 DEG C scopes one or more in ether, normal butane, iso-butane
Interior any one temperature section, deviation is not more than 5 DEG C.
Below with the role of component, content range and each component in forms mode explanation composition.
Content in table is the mass percent of relative combinations amount of substance.
Wherein propane/dimethyl ether/normal butane/iso-butane/as refrigerant, HFC-134a/HFO-1234ze/ nitrogen/bis-
Used as hypertensor, propane diols/ethanol/glycerine/tween is wetting agent to carbonoxide.
Tween refers to polysorbate in table, a kind of nonionic surface active agent.
HFC-134a refers to HFA 134a in table.
HFO-1234ze refers to trans 1 in table, 3,3,3- tetrafluoropropenes.
Whether the auxiliary agent of above-mentioned alternatively component, add the key property for not influenceing product;Add levorotatory menthol tool
There is peppermint fragrance and have refrigerant, add racemization menthol to have refrigerant effect.
Beneficial effects of the present invention:
The present invention is that refrigerant is canned with wetting agent combination aerosol, by pressing aerosol valve compared with prior art
On actuator make composition from inhalator jar in vaporific ejection, Quick-gasifying moment produces refrigerating effect because of a large amount of heat absorptions,
At -10 DEG C~-30 DEG C, moment cold temperatures can be by depending on the constituting of refrigerant for moment cold temperatures;Composition contains wetting agent, makes
Spray injection to cooling during human body skin hold time it is shorter, apply the local temperature of spray close to the level applied before spray after 15 minutes,
Avoid the cold adverse reaction such as burn;The valve rod of aerosol valve is symmetrical or shifts to install the 2-4 metering orifice of aperture 0.3mm-0.6mm,
Actuator integral structure and micro- atomizer ejiction opening aperture Φ 0.4mm-1.0mmm, quick break when making ejection, with pencil mist
Spray and with certain assault sense to significantly increase analgesic effect, under the synergy of hypertensor, it is ensured that product is whole
The injection pressure of usage cycles is constant and keeps atomizing effect, it is to avoid micro- atomizer is de- in course of injection spray, so as to expand product
The application field of product.
Hypertensor in composite spray of the present invention uses inert gas, and with many advantages, one is to ensure that product
Product are constant in the injection pressure of whole usage cycles and keep atomizing effect;Two is ejiction opening knot when can be prevented effectively from continuous injection
Ice and the phenomenon that blocks;Three is the combustibility for reducing ejecta, improves the security of product.
Brief description of the drawings
Fig. 1 is aerosol valve structural representation of the invention;
Fig. 2 is the structural representation of aerosol valve valve rod of the invention;
Fig. 3 is actuator construction schematic diagram of the invention.
In above-mentioned accompanying drawing:1- valve rods;2- metering orifices;The micro- atomizers of 3-;4- squit holes.
Specific embodiment
In order to preferably explain the present invention, it is described further in conjunction with specific examples below, but the present invention is not limited
In specific embodiment.
Embodiment 1
One kind analgesia cryospray agent composition, including following component by mass percentage:
Spray ingredient names | Content (%, w/w) |
Propane | 50 |
Iso-butane | 44.5 |
Carbon dioxide | 5 |
Propane diols | 0.5 |
Aerosol valve and actuator:4 metering orifices of aerosol valve valve rod, aperture Φ 0.6mm;The micro- atomizer squit hole hole of actuator
Footpath Φ 0.6mm.
Embodiment 2
One kind analgesia cryospray agent composition, including following component by mass percentage:
Spray ingredient names | Content (%, w/w) |
Propane | 40 |
Iso-butane | 44.6 |
HFC-134a | 15 |
Ethanol | 0.4 |
Aerosol valve and actuator:2 metering orifices of aerosol valve valve rod, aperture Φ 0.8mm;The micro- atomizer squit hole hole of actuator
Footpath Φ 0.8mm.
Embodiment 3
One kind analgesia cryospray agent composition, including following component by mass percentage:
Spray ingredient names | Content (%, w/w) |
Normal butane | 80.5 |
HFO-1234ze | 15 |
Nitrogen | 4 |
Glycerine | 0.48 |
Levorotatory menthol | 0.02 |
Aerosol valve and actuator:4 metering orifices of aerosol valve valve rod, aperture Φ 0.8mm;The micro- atomizer squit hole hole of actuator
Footpath Φ 1.0mm.
Claims (9)
1. the analgesia cryospray agent with specific aerosol valve with actuator, it is characterised in that the valve rod of the specific aerosol valve
Multiple symmetrical or Heterogeneous Permutation metering orifices are set;The specific actuator is integrated actuator;The analgesia freezing gas
Mist agent composition includes refrigerant, hypertensor, wetting agent;The mass content of the refrigerant is the 80-95% of composition, described
The mass content of hypertensor is the 3-19.5% of composition, and the mass content of the wetting agent is the 0.5-2% of composition.
2. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 1, it is characterised in that institute
State on the valve rod of specific aerosol valve 2-4 metering orifice of setting, metering orifice symmetrically or is shifted to install, aperture Φ 0.3mm-0.6mm;Institute
Specific actuator is stated for unitary actuator, actuator realizes that machinery is smashed with micro- atomizer integrated structure(Without filling in addition
Embedding micro- atomizer), micro- atomizer squit hole aperture is 0.4mm-1.0mm.
3. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 2, it is characterised in that spray
When going out can quick break, gone out with pencil spray painting and with certain assault sense, strengthen analgesic effect.
4. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 1, it is characterised in that institute
State at least one during refrigerant is selected from propane, dimethyl ether, normal butane, iso-butane;The hypertensor is selected from HFC-134a, HFO-
At least one in 1234ze, nitrogen, carbon dioxide;The wetting agent be selected from propane diols, ethanol, glycerine, tween at least
It is a kind of.
5. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 1, it is characterised in that logical
The composition of adjustment refrigerant is crossed, moment cold temperatures can be made to be adjusted between -10 DEG C~-30 DEG C.
6. the analgesia cryospray agent with specific aerosol valve Yu actuator according to claim 1, it is characterised in that logical
Cross the composition of adjustment hypertensor, it can be ensured that spray is constant in the injection pressure of whole usage cycles and keeps atomizing effect, and
The phenomenon that ejiction opening is blocked by icing when being prevented effectively from continuous injection.
7. the analgesia cryospray agent with specific aerosol valve and actuator according to claim 2,4 or 5, its feature exists
In, when being ejected into human body skin, cooling is held time shorter, and the local temperature of spray is applied after 15 minutes close to the level applied before spray,
The cold adverse reaction such as burn can be avoided.
8. the preparation method of the analgesia cryospray agent with specific aerosol valve and actuator described in, it is characterised in that including
Following steps:
(1)The wetting agent of 0.5-2% is weighed according to mass percent;
(2)By step(1)The wetting agent of gained, is measured by micro-precision metering device by predetermined value, is poured into inhalator jar, then
Specific aerosol valve is filled, is sealed;
(3)According to mass percent to the refrigerant that 80-95% is filled in inhalator jar, according still further to mass percent in inhalator jar
The hypertensor of 3-19.5% is filled, the specific actuator is then installed additional and is obtained final product.
9. the preparation method of the analgesia cryospray agent with specific aerosol valve and actuator according to claim 8, its
It is characterised by, by changing minority refrigerant component, can adjust moment cold temperatures, scope is between -10 DEG C~-30 DEG C.
Priority Applications (1)
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CN201710103368.4A CN106821588B (en) | 2017-02-24 | 2017-02-24 | Analgesic freezing spray with specific aerosol valve and actuator |
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CN201710103368.4A CN106821588B (en) | 2017-02-24 | 2017-02-24 | Analgesic freezing spray with specific aerosol valve and actuator |
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CN106821588A true CN106821588A (en) | 2017-06-13 |
CN106821588B CN106821588B (en) | 2019-12-31 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111792187A (en) * | 2020-07-22 | 2020-10-20 | 四川以爱沐爱科技有限公司 | High-pressure mousse bottle |
CN111888077A (en) * | 2020-09-08 | 2020-11-06 | 中山蓓盾运动科技有限公司 | Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof |
CN113577026A (en) * | 2021-08-05 | 2021-11-02 | 中山威习日化科技有限公司 | Aerosol and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1345278A (en) * | 1999-03-30 | 2002-04-17 | 精密阀门公司 | High volume aerosol valve |
CN1615255A (en) * | 2001-12-20 | 2005-05-11 | 精密阀门公司 | Aerosol powder valve |
CN102985188A (en) * | 2010-06-15 | 2013-03-20 | 株式会社大造 | Nozzle hole mechanism |
CN103153816A (en) * | 2010-10-06 | 2013-06-12 | 林达尔法国两合公司 | Diffuser for a multi-way valve |
CN105764814A (en) * | 2013-11-29 | 2016-07-13 | 株式会社大造 | Content-accommodating container, content-accommodating product using same, discharging product, and discharging device |
-
2017
- 2017-02-24 CN CN201710103368.4A patent/CN106821588B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1345278A (en) * | 1999-03-30 | 2002-04-17 | 精密阀门公司 | High volume aerosol valve |
CN1615255A (en) * | 2001-12-20 | 2005-05-11 | 精密阀门公司 | Aerosol powder valve |
CN102985188A (en) * | 2010-06-15 | 2013-03-20 | 株式会社大造 | Nozzle hole mechanism |
CN103153816A (en) * | 2010-10-06 | 2013-06-12 | 林达尔法国两合公司 | Diffuser for a multi-way valve |
CN105764814A (en) * | 2013-11-29 | 2016-07-13 | 株式会社大造 | Content-accommodating container, content-accommodating product using same, discharging product, and discharging device |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111792187A (en) * | 2020-07-22 | 2020-10-20 | 四川以爱沐爱科技有限公司 | High-pressure mousse bottle |
CN111888077A (en) * | 2020-09-08 | 2020-11-06 | 中山蓓盾运动科技有限公司 | Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof |
CN113577026A (en) * | 2021-08-05 | 2021-11-02 | 中山威习日化科技有限公司 | Aerosol and preparation method thereof |
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