CN106806486A - A kind of traditional Chinese medicine for external application for treating pathogen of suppurative otitis media in children - Google Patents

Abstract

A kind of traditional Chinese medicine for external application for treating pathogen of suppurative otitis media in children, the parts by weight of various raw materials are in the external preparation：10~20 parts of the capsule of weeping forsythia, 10~20 parts of schizonepeta, 10~20 parts of kuh-seng, 10~20 parts of rheum officinale, 10~20 parts of borneol, 10~20 parts of golden cypress, 10~20 parts of the root of large-flowered skullcap, 10~20 parts of stir-baked FRUCCTUS XANTHII, 10~20 parts of peppermint, 10~20 parts of indigo naturalis, 10~20 parts of Asian puccoon, 10~20 parts of the red sage root, 10~20 parts of dandelion, 10~20 parts of rhizoma atractylodis, 10~20 parts of the root of Dahurain angelica.Medicine of the present invention have good clearing heat and detoxicating, eliminating dampness and astringing sores, remove necrosis and promote granulation, exorcise evil spirits analgesic effect, and have functions that dry ear is fast, curative effect is short, have no side effect.For tympanitis patient, secretion can be promoted to disappear and to be absorbed, the eardrum reparation of perforation makes auditory rehabilitation.The present invention has various effects such as antibacterial, anti-inflammatory, convergence, dehumidifying, sensible, analgesic.

Description

A kind of traditional Chinese medicine for external application for treating pathogen of suppurative otitis media in children

Technical field

The present invention relates to contain the medicinal preparation from plant, animal or mineral component, more particularly to A kind of traditional Chinese medicine for external application for treating pathogen of suppurative otitis media in children.

Background technology

Tympanitis is the inflammation of middle ear tympanic mucosa.Caused by bacterium infection more.The traditional Chinese medical science this disease is called " ear Purulence ", " suppurative otitis media ", it is believed that caused because liver and gallbladder damp-heat (fire) perverse trend is prevailing.Be involve middle ear (including Tubotympanum tympanic antrum and mastoid air cell) all or part of structure inflammatory lesion absolutely, it is most of for non- Specificity arranges inflammation, often betides less than 8 years old children, and the crowd of other age brackets also has generation, it The Pain Complication that often infection of the upper respiratory tract such as common cold or throat infection is triggered.Chronic middle ear Inflammation is MEM, eardrum or the chronic inflammation as deep as sclerotin, and presence is often merged with chronic mastoiditis.It is anxious Property tympanitis fail treatment in time, or the state of an illness is heavier, it is also possible to form chronic otitis media.Due to otalgia not Substantially, children main suit is unclear, and when children's hearing is affected, parent just has found to go to a doctor, and usually delay is examined Disconnected and treatment.Otology training checks that visible eardrum is in amber or crocus, also visible air fluid level or gas Bubble, the reduction of eardrum mobility.Tympanitis children are common.The hearing loss of children can be caused, speech is influenceed Development of speech, answers highly vigilant of and timely observation and treatment.For adults with unilateral lesion person, should be clear and definite as early as possible The cause of disease, excludes the occupancy tumour of pharynx nasalis and its peripheral clearance, as early as possible relief of symptoms, matter of making the life better Amount.

Research finds that about 90% preschool child suffered from tympanitis, and 25% school-ager suffers from middle ear It is scorching.It is most commonly in June~4 year old children.The children for suffering from tympanitis during by 1 years old more than 50%, during by 2 years old Increase to 60%.Many breaking-outs were voluntarily disappeared at 3 months, and about 30%~40% otitis media in children can recur. 5%~10% infant tympanitis continues more than 1 year.In the U.S., in thering are 2,002,000,000 to be diagnosed as every year The infant of otitis, the direct and consequential damage for causing every year is estimated up to 4,000,000,000 dollars.

It is relevant that infant is susceptible to suffer from the tympanitis anatomical structure special with infant.Neonatal Eustachian tube is short, Wide and straight, secretion The book of Changes Eustachian tube of pharynx nasalis causes inflammation into middle ear.Difficult labour, stern during childbirth The neonate of artificial respiration was made in position, room when ceasing, amniotic fluid Chang Yi enters in middle ear.Parent suffers from gestosis Also easily there is infection into middle ear and cause tympanitis in disease, pre-eclampsia or ante partum hemorrhage person, amniotic fluid.It is newborn The improper easily inverse breast of youngster's lactation, dorsal position of particularly making even feeding bottle does not manually feed person, milk pool during inverse breast Product causes tympanitis through Eustachian tube in nasopharyngeal cavity into middle ear.

The clinical manifestation of tympanitis is mainly Hearing, can change with position chanP, slight otalgia, Tinnitus, sense that ear is vexed swollen and inaccessible, the audible underwater sound of shaking the head.Otology training checks visible otopiesis, is in Amber or color and luster shades, also visible air fluid level or bubble, the reduction of eardrum mobility.

Infant is then shown as to ambient sound Low Response, grabs ear, and sleep is easily waken up, irritability.Baby couple The sound of surrounding is not reacted, it is impossible to which head is turned into sound source exactly；Even if infant does not have under main suit's hearing Drop, household then find careless infant, behavior change, it is reactionless to normal dialog, see TV or Always sound is opened very big during using hearing device；For the otitis media acuta of recurrent exerbation, should be vigilant In the tympanitis that the breaking-out intermittent phase may continue；School grade is poor；Balanced capacity is poor, unknown cause it is stupid My；Verbal language hypoevolutism.

Infant and otitis media in children should mutually differentiate with otitis media acuta.Otitis media acuta treatment thoroughly or Protracted course of disease can be exchanged into tympanitis.Many courses of disease are shorter, and patient can have the symptoms such as violent otalgia, discharging ear, The many courses of disease of tympanitis are more long, more vexed as cardinal symptom with ear, and otalgia is in discontinuity, gentlier, or even earless Pain is showed.

Because tympanitis is self-limited disease, there is certain self-healing rate, patient should before invasive treatment is given The close observation March.Whether self-healing depends on the cause of disease and the length of hydrops time to tympanitis.In acute The tympanitis patient that otitis is left, about 75%~90% can be switched to self-healing, tympanogram in March by B A, c-type.About 55% tympanitis patient can the self-healing in March, but, about 1/3 infant may be aggravated. In onset time ominous 2~4 years old infant, about 25% infant self-healing time is 3 months.Baby and small The self-healing rate of children is higher.More than 2 years old ears tympanitis, the courses of disease in March above infant, in 6~December Its self-healing person is about 30%.

For in observation the stage non-high-risk children, either medicine or surgical intervention then hundred do harm to and nothing One profit, and observe and wait to non-high-risk children then without harm；Need to inform that household's infant hearing is poor, especially It is ears tympanitis patient；Formulating improves infant listening and the measure of academic environment and scheme；Periodic review, Go forward side by side promoting the circulation of qi clamp lug mirror and tympanogram inspection.

For children, curative effect of medication is of short duration and limited, and side effect is more, does not recommend.Do not advocate long-term Using antibiotic therapy tympanitis, the congested indication that should not turn into antibiotic application of eardrum (has 5% middle ear It is congested that scorching infant also can behave as eardrum), do not advocate antihistamine and decongestant is used in combination, because he Side effect it is obvious.Generally long-term use oral hormone treatment is not advocated, unless single cases yet. Evidence there is no to support Eustachian tube ventilation, the treatment of oral or Injection in Tympanic Cavity mucus eccritic and other drugs Effect.

The medicine of existing Chinese medicine treatment tympanitis is less, main reason is that, curative effect is not notable, and what is had controls The treatment cycle is up to several weeks.The medicine of tympanitis is treated in the prior art, is mostly to use Western medicine anti-inflammatory, it is right For children, side effect is more, does not recommend；Traditional Chinese herbal decoction is oral, and poor taste, infant does not also connect Receive.Only traditional Chinese medicine for outer use is the properest, focus of going directly.Exploitation is adapted to the treatment middle ear that children use Scorching new drug is exactly the present task of top priority.

The content of the invention

The technical problems to be solved by the invention are to treat the medicine of tympanitis in the prior art, mostly It is to use Western medicine anti-inflammatory, for children, side effect is more, does not recommend, to human injury than larger； Traditional Chinese herbal decoction is oral, and poor taste, infant does not also receive.Only traditional Chinese medicine for outer use is the properest, directly Up to focus.The new drug that exploitation is adapted to the treatment tympanitis that children use is exactly the present task of top priority.

To solve these technical barriers, the invention provides a kind of Chinese medicine for treating pathogen of suppurative otitis media in children External preparation, the parts by weight of various raw materials are in its external preparation：10~20 parts of the capsule of weeping forsythia, schizonepeta 10~20 parts, 10~20 parts of kuh-seng, 10~20 parts of rheum officinale, 10~20 parts of borneol, 10~20 parts of golden cypress, 10~20 parts of the root of large-flowered skullcap, 10~20 parts of stir-baked FRUCCTUS XANTHII, 10~20 parts of peppermint, 10~20 parts of indigo naturalis, Asian puccoon 10~ 20 parts, 10~20 parts of the red sage root, 10~20 parts of dandelion, 10~20 parts of rhizoma atractylodis, 10~20 parts of the root of Dahurain angelica.

The traditional Chinese medicine for external application of the treatment pathogen of suppurative otitis media in children, various originals in its described external preparation The parts by weight of material can be：10~15 parts of the capsule of weeping forsythia, 10~15 parts of schizonepeta, 10~15 parts of kuh-seng, rheum officinale 10~15 parts, 10~15 parts of borneol, 10~15 parts of golden cypress, 10~15 parts of the root of large-flowered skullcap, stir-baked FRUCCTUS XANTHII 10~20 Part, 10~20 parts of peppermint, 10~20 parts of indigo naturalis, 10~20 parts of Asian puccoon, 10~20 parts of the red sage root, dandelion 10~20 parts, 10~20 parts of rhizoma atractylodis, 10~20 parts of the root of Dahurain angelica.

The traditional Chinese medicine for external application of the treatment pathogen of suppurative otitis media in children, various originals in its described external preparation The parts by weight of material can also be：10~20 parts of the capsule of weeping forsythia, 10~20 parts of schizonepeta, 10~20 parts of kuh-seng, greatly It is yellow 10~20 parts, 10~20 parts of borneol, 10~20 parts of golden cypress, 10~20 parts of the root of large-flowered skullcap, stir-baked FRUCCTUS XANTHII 10~ 15 parts, 10~15 parts of peppermint, 10~15 parts of indigo naturalis, 10~15 parts of Asian puccoon, 10~15 parts of the red sage root, Pu Gong 10~15 parts of English, 10~15 parts of rhizoma atractylodis, 10~15 parts of the root of Dahurain angelica.

In order to solve the above technical problems, treating pathogen of suppurative otitis media in children present invention also offers a kind of The preparation method of medicine external preparation, the formulation of its preparation is drops, and preparation method includes：

A, first by the capsule of weeping forsythia, peppermint, indigo naturalis, borneol and stir-baked FRUCCTUS XANTHII distillation crystallize into powder；It is component 1,

B, again by the dregs of a decoction after distillation and remaining raw material be put into ethanol immersion, heat extract, into medicinal extract shape, It is component 2；

C, by said extracted thing mix be condensed into pasty state, add sesame oil, bottling.

In step a, can first by the capsule of weeping forsythia, peppermint, indigo naturalis, borneol and stir-baked FRUCCTUS XANTHII steam method Distillation, obtains crystal, is then comminuted into fine powder；It is standby as component 1.

In the step b, the dregs of a decoction and surplus stock after distillation can be taken and add the 5-10 times of 60-90% for measuring Ethanol soaks 1-2 hours, and heating extraction 2 times is each 1-2 hours, removes supernatant, merges extract solution, 80-120 mesh is filtered, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, and ultrafiltrate decompression is dense 1.36 medicinal extract when contracting relative density is 80 DEG C, heating concentration, 30 minutes~45 minutes, extract activity into Part, concentrate is settled into medicinal extract shape, mass continues heating and is concentrated into medicinal extract shape, and stand for standby use turns into Component 2.

In the step c, the dregs of a decoction medicinal extract component 2 that the component 1 extracted is put into ethanol extraction can will be distilled In, plus sesame oil immersion can bottle and use for 5-10 days.

In order to solve the above technical problems, treating pathogen of suppurative otitis media in children present invention provides a kind of The preparation method of medicine external preparation, the external drug dosage forms include for the preparation process of spray：

A, will first by the capsule of weeping forsythia, peppermint, indigo naturalis, borneol and stir-baked FRUCCTUS XANTHII distillation crystallize into powder；It is group Point；

B, dregs of a decoction mixing surplus stock added into ethanol heating and refluxing extraction again；

C, by above two extract merge, ethanol is recovered under reduced pressure and concentrate suction filtration absorption, obtain medicinal powder and add Solvent is fitted into Aerosol Products for Medical Use.

In the step b, can will distill the dregs of a decoction and be put into 10 times of amount ethanol, heating and refluxing extraction 2 times, 1~2 hour every time, No. 2 extract solutions are merged into filtering and standing；In the step c, it is characterised in that will Extract merges twice, and ethanol is recovered under reduced pressure and liquor strength is concentrated into for 0.4g crude drugs/mL, after suction filtration, 1.06 when the relative density of filtrate is about 20 DEG C；Above-mentioned filtrate is the large pore resin absorption column of 10L through volume, First with the deionized water or distillation water elution of 10 times of resin column volumes, then with 5 times the 95% of resin column volume Ethanol elution, collects ethanol eluate, removes solvent, obtains what raw material medicinal powder mixing abovementioned steps were obtained Distillation crystalline powder, solubilizer is fitted into Aerosol Products for Medical Use.

The traditional Chinese medicine for external application of the treatment pathogen of suppurative otitis media in children, its described external preparation formulation can be with For：Drops, spray, ointment, tincture, irrigation and absorbent cotton suppository, pulvis, powder, ointment, Suppository, emplastrum and creme.

Application method：Before use, patient's Er Nei festers are cleaned up, after drying, by medicine of the present invention The powder that thing is made is sprayed or brushed to patient Er Nei a little, its mucomembranous surface is gently covered one layer of powder, such as This does not result in duct blocking, is conducive to suffering from ear mucous membrane and locally fully absorbs medicine, the curative effect for having obtained. Daily medication 1 time, 1-7 days is a course for the treatment of.

Medicine of the present invention have good clearing heat and detoxicating, eliminating dampness and astringing sores, remove necrosis and promote granulation, exorcise evil spirits analgesic work With, and have functions that dry ear is fast, curative effect is short, have no side effect.For tympanitis patient, can promote Secretion disappears and absorbs, and the eardrum reparation of perforation makes auditory rehabilitation.The present invention have antibacterial, anti-inflammatory, Various effects such as convergence, dehumidifying, sensible, analgesic.Toxic and side effect of the present invention is small, and antimicrobial spectrum is wider, no Drug resistance is also easy to produce, inner ear is acted on without overt toxicity, it is especially sensitive to tympanitis fester antimicrobial spectrum, The synthesis of bacterioprotein can be suppressed and the purpose of sterilization is reached, it is to avoid some Chinese medicine preparation local applications Afterwards, produce earwax be difficult to eliminate the characteristics of, with dry ear it is fast, curative effect is high, short treating period, Small side effects, The characteristics of medicine source is wide.

Chinese medicine composition safety of the present invention, toxic and side effect is small, and suitable children use, and without dependence. Its application method is simple, and healing time is short, controls difficulty in relapse after healing.Can create preferable social value and Economic interests.

Specific embodiment

This disease is referred to as " ear purulence ", " suppurative otitis media " by the traditional Chinese medical science, it is believed that be because liver and gallbladder damp-heat (fire) perverse trend is prevailing Cause.Tympanitis was often broken out in winter, and itself is not infectious, but a flu can be a lot Their generation ear infections are propagated and caused in the middle of child.Tcm theory thinks, otalgia, discharging ear liquid, The symptom such as fester, be the fire of upper inflammation, manadesma then eardrum severe pain of burning, retention and fumigation of damp-heat inside the body then degenerates gathering. Technical scheme is exactly, according to above-mentioned theory, to be put on flesh according to clearing heat and detoxicating, eliminating dampness and astringing sores, myogenic Effect prepare medicinal material.Traditional Chinese medicine thinks that tympanitis is relevant with yin-Yang imbalance, derangement of Qi and blood, wet Heresy invasion, internal body fluid operation imbalance be its Etiological interpretation of the cause, onset and process of an illness, can according to the different times of disease, no Effective diagnosis and treatment based on an overall analysis of the illness and the patient's condition is carried out with pathological condition, such as acute stage is sensible with wind dispelling heat-clearing, try hard to eliminate Eustachian tube And middle-ear mucosa oedema, congestive state；When middle ear effusion is more, then based on clearing damp and promoting diuresis, try hard to adjust Whole ETF, improves ciliary movement function, to promote fluid removal；Later stage based on the promoting flow of qi and blood circulation, Try hard to prevent lesion from developing to adhesive otitis media, and adjust function, building up healthful vital energy reduces middle ear The chance of inflammation recurrence.

Theory of the modern medicine on tympanitis be：This disease is on the basis of obstruction of eustachian tube, or in this base Caused by being infected on plinth, be divided into mechanicalness with inflammatory two kinds, inflammation is divided into infective inflammation and change again State reactivity.Therefore treatment using antibiotic, antihistamine, nasal cavity vaso-excitor material be easy to MEV with Excretion, tympanum drawing liquid or injection hormone therapy.

The traditional Chinese medical science thinks that this disease is generally wind attacking the lung, and through gas ruffian plug, Lung Qi obstruction causes water channel obstructed, wet turbid to stop gathering Caused by ear key.Because middle ear drainage does not wait many reasons freely, make this disease touching refractory.Motherland's medical science by its It is classified as " otitis media suppurativa ", it is believed that be that deficiency of spleen and stomach, wet turbid fiery poison are accumulate and caused long.The traditional Chinese medical science thinks this sick interpretation of the cause, onset and process of an illness Caused by being water retention due to hypofunction of the spleen, Committed obsessed ears.Children have the physilogical characteristics of asthenic susceptibility of spleen, asthenic susceptibility of kidney.Spleen is The foundation of acquired constitution, main transmitting and distributing the fluids and biochemical qi and blood, clear key is gone out on defeated clear sun,《Compendium of medicine》Meaning：" taste One is empty, knowledge nine orifices all diseases ", weakness of the spleen and the stomach then lucid yang failing to raise, ear key lose its it is warm support, it is more simultaneous insufficiency of the spleen not change Water is wet, the wet tired knot ear key of water, therefore pus is for years in ear does not do, lucid yang failing to raise therefore dizziness and tinnitus and lose It is clever and quick, sallow complexion is simple and unadorned be for insufficiency of the spleen insufficiency of vital energy and blood as；Deficiency of food abdominal distension, half congealed during stool is also spleen Void has wet levying.Therefore suitable invigorating the spleen excreting dampness is treated, mend support apocenosis.

External application kuh-seng, the capsule of weeping forsythia, bactericidal antiphlogistic, golden cypress cool blood toxin expelling, indigo naturalis antiphlogistic antibacterial；Peppermint cool blood Dehumidifying, the root of large-flowered skullcap and borneol apocenosis, expelling pus and promoting granulation；Schizonepeta anti-inflammation and sterilization, promoting blood circulation foster skin, it is clearing heat and detoxicating, Effect that root of Dahurain angelica myogenic is put on flesh.All medicines share has invigorating the spleen excreting dampness, and clearing heat and detoxicating, eliminating dampness and astringing sores, myogenic are long Effect of meat.

Root of Dahurain angelica meridian distribution of property and flavor：It is pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and clearing away cold, sensible analgesic, detumescence row Purulence, eliminating dampness stops band.《Japan hanako materia medica》：The hot eyes triangular mass of mucous membrane growing from the inner corner of the eye is controlled, and tire patching leakage slides, and breaks place blood, mends New blood, acute mastitis, carbuncle on the back, scrofula, intestines wind, hemorrhoid complicated by anal fistula, apocenosis, desolation, mange relieve pain myogenic, go Face Shao- defect scars.

Kuh-seng is bitter, trembles with fear.The thoughts of returning home, liver, stomach, large intestine, bladder warp heat-clearing and damp-drying drug, desinsection, diuresis. For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, fungal dermatopathy, wet sore, Pruitus, mange leprosy；Often it is used in combination with Hedyotidis Diffusae, is the external application for treating fungal dermatopathy Good medicine.

The root of large-flowered skullcap：The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, the upper respiratory tract Infection, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, The diseases such as carbuncle swells furuncle sore.The clinical practice antibacterial of the root of large-flowered skullcap is not worse than the coptis, and does not develop immunity to drugs.We By broad-spectrum antibacterial action it is strong the characteristics of, it is special severe used in the infection of fungal culture miscellaneous bacteria, use root of large-flowered skullcap extract solution Effect is fine.《Bencao Jingshu》：The root of large-flowered skullcap, its property is respectful clearly, so evil removing：Bitter is so eliminating dampness；It is cloudy Tremble with fear so victory is hot, therefore leads all heat.All hot persons, heat symptoms caused by an exopathgen are with all over heat, and jaundice, intestines are out-of-the-way, let out dysentery, all wet The disease of hot victory, analyses it, then all sick from recover.Bitter cold can except damp and hot, so small intestine profit and water from by, Then flow clearly clean in source.The blood person of closing, in blood system, i.e. thermal man's blood room, it is obstructed to make us Amenorrhea, damp and hot solution for real heat, Then Ying Qi is clearly and voluntarily.Sore subcutaneous ulcer erosion person is disliked, blood-head then stays knot, and is that carbuncle swells stain is rotten：Fiery ulcer person, Internal heat blood trouble, cool blood is except heat, then self-healing.The root of large-flowered skullcap has antiallergic action and antiinflammatory action：Root of large-flowered skullcap institute Can substantially suppress sensitized guinea pig rat small intestine in vitro with isolated tracheal to produced by antigen containing baicalin and baicalein Anaphylaxis contractile response, to the passive general allergy and cavy passivity skin of cavy and mouse Skin allergy, baicalin also has inhibitory action with baicalein.The root of large-flowered skullcap has refrigeration function, majority experiment card Bright, the effective ingredient baicalein of the root of large-flowered skullcap has refrigeration function.The root of large-flowered skullcap has detoxication, and baicalin has substantially Detoxication, this is probably because in the presence of glucuronidase, baicalin decomposites Portugal Grape uronic acid, and combined with various poisonous substances caused.The LD 50 that 10 milligrams of baicalin can improve strychnine reaches 2.5 times, and increase the hepatic glycogen content of carbon tetrachloride poisoning mouse.

Rheum officinale is cold in nature, bitter, is one kind of qi-activating drug.Mainly enter Liver Channel, catharsis liver is hot, promoting qi circulation and relieving pain, Have except damp and hot, clearing away the liver-fire, analgesic, desinsection function.Except damp and hot, clearing away the liver-fire, analgesic, desinsection.Control Pyretic epigastralgia, hypochondriac pain, colic, abdominal pain due to enterositosis.《This warp》：" main temperature disease, typhoid fever are too hot tired mad, kill Three worm scabies are stolen, diuresis water channel.″

Indigo naturalis heat, middle benefit gas, analgesic, qi-regulating, eliminating dampness controls inverse acid regurgitation of vomitting, and jueyin headache, the cold syndrome in infant is told Rush down, abdominal distention, dysmenorrhea, Diarrhoea, vascular hypertension, tinea pedis, hernia, aphthous ulcer, Dentalgia, fungal dermatopathy.Taste is pungent, hardship, eliminating cold to stop pain, enter liver, spleen, stomach, large intestine, kidney channel. External application has obvious analgesic and therapeutic effect.《Thunder God processes property of medicine solution》：Middle benefit gas, analgesic, Qi-regulating, eliminating dampness.《This warp》Carry：Inverse fever and chills are coughed in main warming the middle warmer and descending qi, analgesic, and dehumidify blood-arthralgia, by wind Heresy, loosing the interspaces of skin and muscles is the good medicine for treating skin disease external application.

Golden cypress heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, under band, heat Drench, tinea pedis, impotence is warded off, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema itch.Golden cypress enriching yin Fall fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.《Chinese Pharmacopoeia》The power of golden cypress heat-clearing and damp-drying drug is carried, with Huang A kind of reed mentioned in ancient books, the coptis are similar, but are preferred with except lower the damp and hot of Jiao.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, invigorate blood circulation, relieving restlessness that clears away heart-fire.For the moon Through uncomfortable, closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, it is vexed not Sleep.For sternal rib hypochondriac pain, arthralgia pain due to rheumatism, abdominal mass caking, sore swell and ache curative falls grieved, irregular menstruation of falling forward, Closed dysmenorrhea, postpartum stasis caused pain etc..Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea Pain has good effect.《Detailed outline》Carry：The red sage root, presses《The sensible opinion of married woman》Cloud, Siwu Tang controls gynecopathy, Pay no attention to antenatal postpartum, through water how much, it is all generally applicable, the only taste red sage root dissipate, cure mainly same.Gai Dan Joining can break place blood, the new blood of benefit, peaceful tire, and fall stillborn foetus, under only metrorrhagia is stagnant, menstruation regulating arteries and veins.

Peppermint is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, head Pain, hot eyes, body heat, throat, gum such as swell and ache the disease.Place's use can control neuralgia, pruitus, fash With eczema etc..The peppermint of light friend's Greenhouse Fruit Picking is again the fresh vegetable on Spring Festival dining table.It is salubrious good to eat.Usually with For tea, clear away heart-fire peppermint improving eyesight.Peppermint has extremely strong sterilized antibacterial action, and often drinking it can preventing viral sense Emit, mouth disease, make breath freshening.Gargled with peppermint tea juice, can be pre- anti-halitosis.Use mint tea mist Steaming face, the also effect of shrinking pore.Applied by the blade for steeping tea and refrigerant, energy is may feel that on eyes Release eye fatigue.It is said that peppermint also has the another name of " eyes grass ", can be used to treat eye illness.

Schizonepeta taste is put down, and warm in nature, nontoxic, faint scent is dense.Schizonepeta is sweating, and alexipyretic is conventional China One of herbal medicine.Can town phlegm, timid wind, cool blood.Control influenza, headache fever and chills sweating, vomiting.Wind-dispelling； Inducing diaphoresis；Promoting eruption；Hemostasis.Main cold, fever；Headache；Eye itching；Cough；Abscess of throat；Measles；Carbuncle It is swollen；Sore scabies；Bleeding from five sense organs or subcutaneous tissue；Spit blood；Have blood in stool；Uterine bleeding；Postpartum anemic fainting.For catching a cold, headache, measles, Rubella, sore from the beginning of.《Detailed outline》：Dissipate wind-heat, refresh oneself, throat, disappear sore swells.Control Xiang Qiang, Black flower in mesh, and raw sore, it is cloudy ruined, spit blood, bleeding from five sense organs or subcutaneous tissue, lower blood, bloody flux, metrorrhagia, anal fistula.

Asian puccoon is cold in nature, it is sweet, into.The thoughts of returning home, Liver Channel.Indication cool blood, promoting blood circulation, promoting eruption of detoxifying. For blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption, sore, eczema, scald.Clearing heat and cooling blood, For measles, pyreticosis ecchymosis, eczema, hematuria, blood strangury, bloody flux, sore, erysipelas, burn, thermojunction Constipation.

Capsule of weeping forsythia expelling cold, eliminating, clearing the nasal passage, cough-relieving, removing toxic substances.《Detailed outline》：Removing toxic substances, improving eyesight dissipates hot eyes Swollen, cloudiness, deaf, olic acid of having a headache, controls Tan Nve Snore clams, has a stuffy nose obstructed, and plug breath dissipates sore again from falling It is swollen.《Detailed outline》：Grass is eaten in goose, above up to brains, and top pain mesh disease is controlled, leads to nose gas and the flat meat that falls；It is interior Zhi Snore clams, phlegm malaria up to lung channel, dissipate sore swells；Its work(for removing screen, shows wonderful especially.By Ni Weide《Former machine Qi Wei collection》Cloud：Control mesh screen nose, the removing toxic substances of the Biyun powder capsule of weeping forsythia is monarch, it is assistant that indigo naturalis is reduced phlegm and internal heat, river grass it is pungent It is broken to stay evil removing to make, rise saturating medicine.On the whole such as boil lid method, be often intended to evil poison and do not close, order has outlet. Right power is small and sharp, suitable Chang Yiju its power, and all diseases in all mesh all can use it, give birth to more refreshing.

Stir-baked FRUCCTUS XANTHII astringing to arrest bleeding, detumescence and promoting granulation.Spitted blood for hemoptysis, traumatism and bleeding, sore swollen toxin, Chapped skin；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.1. anastalsis：Stir-baked FRUCCTUS XANTHII can strengthen blood platelet Factor III activity, significantly shortens the clotting time and factor forms the time, suppresses fibrinolysin Activity, has anastalsis to local hemorrhage；Zoopery shows that stir-baked FRUCCTUS XANTHII water extraction is to substance The external application haemostatic effects such as organ (liver, spleen), muscle vascular bleeding are quite good.2. gastric mucosa is protected：1% Stir-baked FRUCCTUS XANTHII decoction gavage, has protective effect to the rat pipe film injury that hydrochloric acid causes；To anesthetized dog reality The perforation of the property tested Stomach duodenum has therapeutic action.3. antibacterial, antifungic action：Stir-baked FRUCCTUS XANTHII ethanol Immersion liquid has inhibitory action to staphylococcus aureus, hay bacillus, Bacillus tuberculosis；Flooding agent is to Austria Du's big belly sporidiole bacteria has inhibitory action；3 biphenyl classes and 2 double hydrogen phenanthrene classes contained by stir-baked FRUCCTUS XANTHII Compound is to staphylococcus aureus, hay bacillus, Candida albicans ATCC 1057 and trichophyte QM 248 have inhibitory action.

Rhizoma atractylodis are pungent, hardship, temperature.Returns spleen, stomach, Liver Channel.Indication：It is drying damp and strengthening spleen, expelling wind and clearing away cold, Improving eyesight.For abdominal fullness and distention, diarrhea oedema, tinea pedis Wei lame, arthralgia pain due to rheumatism, anemofrigid cold, yctalopia. Main the spleen and stomach being stranded by dampness；Burnout；Born of the same parents' ruffian abdominal distension；Poor appetite；Vomiting and having loose bowel；Phlegm and retained fluid；It is wet swollen；Table Card folder is wet；Head body weight pain；Bi Zheng warm nature；Podomere is ached and is weighed；Impotence folds in a garment.It is antibacterial：Atractylodes chinensis has Play the role of to eliminate resistance shigella flexneri R plasmids, the generation of bacterial drug resistance can be reduced.Using 95% Ethanol immersion rhizoma atractylodis 10 hours, take out rhizoma atractylodis, are positioned ready on the floor of operating room of sterilization, light, directly To rhizoma atractylodis turn to ash, significantly reduced than clump count in air before sterilization after sterilization.However, early stage body Outer research does not find that rhizoma atractylodis decocting liquid has obvious antibacterial action.《Medicineization justice》：Rhizoma atractylodis, taste is pungent master dissipates, It is warm in nature and dry, it is dry to dry, specially enter taste, cure mainly wind-cold-dampness arthralgia, mountainous evil air, hydroderma, all Work(of the Xin Lie by heresy.Three wet is ruled, if wet in the part of the body cavity above the diaphragm housing the heart and lungs, damp phlegm is easily given birth to, with this eliminating dampness row phlegm； Wet in middle Jiao, stagnant gas are rushed down, with invigorating the spleen in this width；It is wet in bottom, sufficient knee impotence is soft, is controlled with golden cypress with this Impotence, can make sufficient knee strong；Take that its pungent scattered gas is male, with scattered evil sweating, extremely freely.Six god are closed to dissipate, General solution spring and summer humidifier；Assistant bupluerum and pueraria decoction for dispelling pathogenic factors from superficial muscles, table dissipate malaria from the beginning of；If after under pyreticosis sweat, abnormal heat is not understood, Baihu Tang is added with this, then solves it, it is cool that sweat stops body.Miao Zhongchun is simply end with this, controls insufficiency of the spleen tympanites due to parasitosis.

Dandelion is Chinese medicine conventional simply, the early loaded various medical books of its medical value.Its all herbal medicine, Containing compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, synanthrin.Property Flat sweet and slightly bitter taste.Can be clearing heat and detoxicating, dispersing swelling and dissipating binds.《Compendium of Materia Medica》Record：" Detoxicating food-poisoning dissipates stagnant Gas, heat-clearing poison, helping digestion poison, the evil that disappears is swollen, tuberculosis, malignant boil swell." dandelion hides sweet flat, its property is nontoxic. When being that enter liver enters stomach, the key medicine of antipyretic cool blood.

The manufacturing process of drops of the present invention is：By capsule of weeping forsythia 1000g, peppermint 1000g, indigo naturalis 1000g, ice Piece 1000g and stir-baked FRUCCTUS XANTHII 1000g, is distilled with steam method, obtains crystal, is then comminuted into fine powder； It is standby as component 1, then will, take distillation after the dregs of a decoction and surplus stock schizonepeta 1000g, root of large-flowered skullcap 1000g, Kuh-seng 1000g, rheum officinale 1000g, golden cypress 1000g, Asian puccoon 1000g, red sage root 1000g, dandelion 1000g, Rhizoma atractylodis 1000g, root of Dahurain angelica 1000g add the 5-10 times of 60-90% ethanol measured to soak 1-2 hours, heating extraction 2 It is secondary, it is each 1-2 hours, supernatant is removed, merge extract solution, 80-120 mesh is filtered, then through the molecule that dams The ultrafiltration post ultrafiltration for 5000-10000 is measured, 1.36 leaching when ultrafiltrate relative density concentrated under reduced pressure is 80 DEG C Cream, heating concentration 30 minutes~45 minutes, extracts active ingredient, and concentrate is settled into medicinal extract shape, Mass continues heating and is concentrated into medicinal extract shape, stand for standby use, as component 2；The component 1 extracted will be distilled to put In entering the dregs of a decoction medicinal extract component 2 of ethanol extraction, plus sesame oil immersion can bottle and uses for 5-10 days.

The manufacturing process of spray of the present invention is：By first by capsule of weeping forsythia 1200g, peppermint 1300g, indigo naturalis 1300g, Borneol 1200g and stir-baked FRUCCTUS XANTHII 1100g distillations crystallize into powder；The dregs of a decoction will be distilled and mixed other remaining originals Material schizonepeta 1200g, root of large-flowered skullcap 1200g, kuh-seng 1300g, rheum officinale 1200g, golden cypress 1100g, Asian puccoon 1200g, Red sage root 1300g, dandelion 1400g, rhizoma atractylodis 1200g, root of Dahurain angelica 1300g are put into 10 times of amount ethanol, heating No. 2 extract solutions 1~2 hour every time, are merged filtering and standing by refluxing extraction 2 times；To close extract twice And, ethanol is recovered under reduced pressure and liquor strength is concentrated into for 0.4g crude drugs/mL, after suction filtration, filtrate it is relatively close 1.06 when degree is about 20 DEG C；Above-mentioned filtrate is the large pore resin absorption column of 10L through volume, first with 10 times of resins The deionized water or distillation water elution of column volume, then with 5 times of 95% ethanol elutions of resin column volume, receive Collection ethanol eluate, removes solvent, obtains the distillation crystalline powder that raw material medicinal powder mixing abovementioned steps are obtained, Solubilizer, is fitted into Aerosol Products for Medical Use

The manufacturing process of external pulvis of the present invention is：Take capsule of weeping forsythia 1100g, peppermint 1300g, indigo naturalis first 1300g, borneol 1200g and stir-baked FRUCCTUS XANTHII 1100g distillations crystallize into powder；The dregs of a decoction will be distilled and mixed it He is surplus stock schizonepeta 1200g, root of large-flowered skullcap 1400g, kuh-seng 1100g, rheum officinale 1300g, golden cypress 1200g, Asian puccoon 1400g, red sage root 1300g, dandelion 1400g, rhizoma atractylodis 1200g, root of Dahurain angelica 1300g are mixed by proportioning, Input pulverizer is ground into fine powder, is put into acid and alkali-resistance infusion kettle after fine powder sieving, at normal temperatures, with second Alcohol impregnates 10~20 days jointly, and the liquid that will have been impregnated and the dregs of a decoction carry out squeeze and filter, and filtrate is taken after separation, Heating is concentrated into pasty state, is put into baking oven, controls at 100 DEG C, is cooled down after drying, directly into powder, directly Connect and use.

The preparation method of externally used paste of the present invention：

According to the number is by capsule of weeping forsythia 1200g, peppermint 1300g, indigo naturalis 1300g, borneol 1400g and fries grey Ears or side handles of a utensil 1200g steam distillations are standby into component 1 into crystallization；It is yellow again by the dregs of a decoction and schizonepeta 1200g A kind of reed mentioned in ancient books 1200g, kuh-seng 1100g, rheum officinale 1300g, golden cypress 1200g, Asian puccoon 1400g, red sage root 1300g, Pu Public English 1400g, rhizoma atractylodis 1300g, root of Dahurain angelica Isosorbide-5-Nitrae 00g add the 5-10 times of 60-90% ethanol immersion 1-2 for measuring Hour, heating extraction 2 times is each 1-2 hours, removes supernatant, merges extract solution, and 80-120 mesh is filtered, The ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, ultrafiltrate relative density concentrated under reduced pressure is 80 DEG C when 1.36 medicinal extract, heating concentration, 30 minutes~45 minutes, concentrate is settled into medicinal extract shape, medicine Paste continues heating and is concentrated into medicinal extract shape, stand for standby use, as component 2；The component 1 and Huang extracted will be distilled A kind of reed mentioned in ancient books 1200g is put into the component 2 of ethanol extraction after crushing, and mixing vaseline is made paste.

The ointment immersion absorbent cotton that can also be obtained in aforementioned manners, into suppository, is directly plugged into sufferer ear.

Claims (4)

1. a kind of traditional Chinese medicine for external application for treating pathogen of suppurative otitis media in children, it is characterised in that described outer Included with the parts by weight of various raw materials in preparation：10~20 parts of the capsule of weeping forsythia, 10~20 parts of schizonepeta, kuh-seng 10~ 20 parts, 10~20 parts of rheum officinale, 10~20 parts of borneol, 10~20 parts of golden cypress, 10~20 parts of the root of large-flowered skullcap is fried grey 10~20 parts of the ears or side handles of a utensil, 10~20 parts of peppermint, 10~20 parts of indigo naturalis, 10~20 parts of Asian puccoon, the red sage root 10~20 Part, 10~20 parts of dandelion, 10~20 parts of rhizoma atractylodis, 10~20 parts of the root of Dahurain angelica.

2. the traditional Chinese medicine for external application of pathogen of suppurative otitis media in children, its feature are treated according to claim 1 It is that the parts by weight of various raw materials include in the external preparation：10~15 parts of the capsule of weeping forsythia, schizonepeta 10~ 15 parts, 10~15 parts of kuh-seng, 10~15 parts of rheum officinale, 10~15 parts of borneol, 10~15 parts of golden cypress, the root of large-flowered skullcap 10~15 parts, 10~20 parts of stir-baked FRUCCTUS XANTHII, 10~20 parts of peppermint, 10~20 parts of indigo naturalis, Asian puccoon 10~20 Part, 10~20 parts of the red sage root, 10~20 parts of dandelion, 10~20 parts of rhizoma atractylodis, 10~20 parts of the root of Dahurain angelica.

3. the traditional Chinese medicine for external application of pathogen of suppurative otitis media in children, its feature are treated according to claim 1 It is that the parts by weight of various raw materials are in the external preparation：10~20 parts of the capsule of weeping forsythia, schizonepeta 10~20 Part, 10~20 parts of kuh-seng, 10~20 parts of rheum officinale, 10~20 parts of borneol, 10~20 parts of golden cypress, the root of large-flowered skullcap 10~ 20 parts, 10~15 parts of stir-baked FRUCCTUS XANTHII, 10~15 parts of peppermint, 10~15 parts of indigo naturalis, 10~15 parts of Asian puccoon, 10~15 parts of the red sage root, 10~15 parts of dandelion, 10~15 parts of rhizoma atractylodis, 10~15 parts of the root of Dahurain angelica.

4. outside a kind of Chinese medicine that pathogen of suppurative otitis media in children is treated as any one of claims 1 to 3 With the preparation method of preparation, it is characterised in that the formulation of the preparation is drops.