CN106806014A - Implanted magnetic seed - Google Patents
Implanted magnetic seed Download PDFInfo
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- CN106806014A CN106806014A CN201510856602.1A CN201510856602A CN106806014A CN 106806014 A CN106806014 A CN 106806014A CN 201510856602 A CN201510856602 A CN 201510856602A CN 106806014 A CN106806014 A CN 106806014A
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Abstract
A kind of implanted magnetic seed that the present invention is provided, including shell region and inner area.Inner area is surrounded and including cavity by shell region.Relative permeability (the μ of at least regional area of at least one of shell region and inner arear) it is more than 2.The implanted magnetic seed that the present invention is provided, there is less volume only to need the small opening just can be implanted into affected part for it, and can be influenceed by additional alternating magnetic field and produce heat energy, thereby the tissue of heat cure affected part.
Description
Technical field
The present invention relates to a kind of magnetic seed, more particularly to a kind of implanted magnetic seed.
Background technology
Benign prostatic hyperplasis (Benign Prostatic Hyperplasia, BPH), is commonly called as prostate hyperplasia
Or behign prostate hypertrophy.Benign prostatic hyperplasis is not cancer, nor can cause cancer, is a kind of
Natural and normal aging phenomenon, often betides the male of more than 50 years old, is the common disease of elderly men.
BPH population in 2014 is in the U.S. about 1,5,000,000 people, the people of Taiwan about 1,140,000, global prostate
The people of loose patient population number about 2.1 hundred million
At present, the therapeutic modality of benign prostatic hyperplasis is, for example, prostate volume is contracted by drug therapy
Small, more serious patient is then to be cut off in the way of performing the operation or destroy prostate.In operative treatment most
Representational method is transurethral prostatectomy.This method just turns into prostate most from nineteen sixty for the later stage
Main operation method.Excision prostate, or warp can also be operated on from belly or perineal incision in addition
Pro ureth laser gasification prostata tissue destroys prostata tissue with radio frequency, microwave heat cure, and its is main
Allow the unobstructed purpose for reaching treatment of patient's urinary tract.
However, the mode of above-mentioned transurethral prostatic resection can cause larger wound to patient, operation is not
Careful also easy injury neck of urinary bladder, causes the problems such as postoperative leakage of urine or retrograde ejaculation, derives numerous concurrent
Disease, and cause that the distress level of therapeutic process and post-operative recovery is higher.Additionally, being treated in the way of performing the operation
At least will half body anesthesia, be mostly to need general anesthesia more particularly, and hyperplasia of prostate is multiple
The elderly is born in, whether anesthetic risks are relative to be improved, therefore can select to be treated in the way of surgical operation
It is different because of sufferer situation.If selection is treated in the way of surgical operation, anesthesia level, energy how are reduced
The following even local anaesthesia of half fiber crops is reduced to, how urethral wall is not destroyed in operation, postoperative urine is reduced
Risk that road infection risk and reduction are performed the operation again etc., it is also desirable to considered in the lump.
Above-mentioned another being mainly in the way of radio frequency or microwave heat cure destruction prostata tissue relies on high
Warm (43 degree Celsius~46 degree or so) make tissue make a variation and dehydration, and make Telatrophy, though unlike foregoing shifting
Except the big wound as tissue, the local heat cure of category, but be easier to recur again (according to the trouble of statistics about 20%
Person can recur again in 3 years), also need to be performed the operation again.Therefore, sufferer how is provided relatively low not
The problem of suitable sense and the treatment method with certain achievement as the exploitation of current important development.
The content of the invention
The present invention provides a kind of implanted magnetic seed, and it has a less volume and only needs the small opening just can to plant
Enter affected part, and can be influenceed by additional alternating magnetic field and produce heat energy, thereby the tissue of heat cure affected part.
A kind of implanted magnetic seed of the invention, including shell region and inner area.Wrapped by shell region inner area
Enclose and including cavity.Relative permeability (the μ of at least regional area of shell region and inner area at least oner)
More than 2.
In one embodiment of this invention, the relative permeability of above-mentioned shell region is more than 2, and inner area
It is non-crystalline material, ferritic material.
In one embodiment of this invention, above-mentioned shell region be non-crystalline material, ferritic material,
And the relative permeability of inner area is more than 2.
In one embodiment of this invention, above-mentioned shell region is all higher than 2 with the relative permeability of inner area,
And shell region is made up of with inner area identical material.
In one embodiment of this invention, the relative permeability of above-mentioned shell region is more than 2, and inner area
It is the cavity.
In one embodiment of this invention, the relative permeability of above-mentioned shell region is more than 2, and inner area
Relative permeability be less than or equal to 2.
In one embodiment of this invention, the relative permeability of above-mentioned shell region is less than or equal to 2, and interior
The relative permeability of heart district is more than 2.
In one embodiment of this invention, the relative permeability of a portion of above-mentioned shell region is more than
2, and the relative permeability of another part of shell region is less than or equal to 2.
In one embodiment of this invention, the surface of above-mentioned shell region be smooth surface, rough surface or
It is with chase or protuberance.
In one embodiment of this invention, above-mentioned inner area includes unconnected multiple cavities.
In one embodiment of this invention, above-mentioned shell region is degradable and relative with the material of inner area
Material of the permeability more than 2.
In one embodiment of this invention, above-mentioned implanted magnetic seed also includes film plating layer, is covered in shell
The material of the outer surface in area, wherein film plating layer is the material with biocompatibility.
Based on above-mentioned, implanted magnetic seed of the invention is suitable for application in temporary transient formula or Yong Liushi organizes heat to control
Treatment technology, as used in the treatment of hyperplasia of prostate, during implantation, implanted magnetic seed can lead to example
Ultrasonic observation to the cavity of inner area is crossed, to confirm position of the implanted magnetic seed in human body.It has been implanted into
After, because implanted magnetic seed is in the phase of shell region and at least one of inner area at least regional area
2 are more than to permeability, if imposing additional alternating magnetic field to implanted magnetic seed, implanted magnetic seed is led relative
Region of the magnetic rate more than 2 can produce the tissue of heat energy and heat cure affected part, to reach the effect for the treatment of.
It is that features described above of the invention and advantage can be become apparent, special embodiment below, and coordinate
Accompanying drawing is described in detail below.
Brief description of the drawings
Fig. 1 is the schematic diagram according to a kind of implanted magnetic seed of one embodiment of the invention；
Fig. 2 is the schematic diagram of the implanted magnetic seed of the Fig. 1 for cutting local open；
Fig. 3 is the schematic diagram according to a kind of implanted magnetic seed of another embodiment of the present invention；
Fig. 4 is the schematic diagram according to a kind of implanted magnetic seed of another embodiment of the present invention；
Fig. 5 A to Fig. 5 H are to impose magnetic field to the implanted magnetic seed as produced by different materials respectively and produce
The simulation schematic diagram of heat energy；
Fig. 6 and Fig. 7 is the schematic diagram according to a kind of implanted magnetic seed of another embodiment of the present invention；
Fig. 8 is the generalized section according to a kind of implanted magnetic seed of another embodiment of the present invention.
Description of reference numerals：
100、200、300、400、500、600：Implanted magnetic seed；
110、210、310、410、510：Shell region；
120、220、620：Inner area；
122、222、622：Cavity；
130、230：Film plating layer；
312：Part I；
314：Part II；
416：Protuberance；
518：Chase.
Specific embodiment
Fig. 1 is the schematic diagram according to a kind of implanted magnetic seed of one embodiment of the invention.Fig. 2 is to cut office open
The schematic diagram of the implanted magnetic seed of the Fig. 1 in portion.Refer to Fig. 1 and Fig. 2, the implanted magnetic seed of the present embodiment
100 are adapted in use to the treatment in benign prostatic hyperplasis or cancer (such as thyroid tumors, liver tumour etc.).
Implanted magnetic seed 100 includes shell region 110 and the inner area 120 surrounded by shell region 110.Shell region
110 with the relative permeability (μ of at least one of inner area 120 at least regional arear) it is more than 2.
Herein it is noted that relative permeability (Relative permeability or Relative magnetic
Permeability, μr) definition be magnetic capacity (μ) and air or the vacuum magnetic capacity (μ of materialo)
Ratio.General ferromagnetic material, such as steel, cobalt, the relative permeability of nickel are more than 100, nonmagnetics
The relative permeability of matter such as copper, aluminium, 304 stainless steels (SUS304), glass etc. is about 1.It is preferred that
On material selection, at least regional area relative of the shell region 110 with least one of inner area 120 is led
Magnetic rate scope is between 160 to 5000.
In the present embodiment, implanted magnetic seed 100 also includes film plating layer 130, positioned at shell region 110
Outer surface.Film plating layer 130 can be plated in the way of wet type (electrochemistry) or dry type (PVD) and be overlying on shell region 110
Outer surface.The material of film plating layer 130 is biocompatible materials (e.g. titanium, the titanium conjunction of implantable
Gold, or as nail SUS316 material, but be not limited system), its thickness about at 0.01 millimeter extremely
Between 0.3 millimeter, in a preferred embodiment, thickness about between 0.01 millimeter to 0.1 millimeter, with
Avoid repelling between implanted magnetic seed 100 and tissue.Certainly, in other embodiments, if shell
The material of the outer surface in area 110 is with biocompatibility implanted material, it is also possible to omit film plating layer
130.The relative permeability of film plating layer 130 is likely less than 2, for example, if the material of film plating layer 130
It is SUS316, then the relative permeability of film plating layer 130 is about 1.02.
Additionally, the biocompatible materials for not being implantable in order to avoid the material of inner area 120, outward
Shell area 110 or film plating layer are needed the complete seal of inner area 120, so as not to inner area 120 with internal group
Knit contact and produce inflammation or other lesions.Certainly, in other embodiments, if inner area 120
Material is the biocompatible materials of implantable, and shell region 110 or film plating layer 130 can also expose
Go out local inner area 120.
In the present embodiment, shell region 110 is different from the material of inner area 120, the material of shell region 110
Material can select marquensite system stainless steel or ferrite system stainless steel, and the material of inner area 120 can select non-
Crystalloid material (such as Fe72B20-XCXSi4Tm4(Tm=Nb, Zr, Mo；X=0,2,4,6,8at%)),
Soft ferrite (e.g. manganese-zinc ferrite, nickel-zinc ferrite) or hard ferrite (e.g. strontium ferrite,
Conjugate ferrite) etc..Certainly, in other embodiments, the material kind of shell region 110 and inner area 120
Class not with the above-mentioned system that is limited, as long as it is relative with least one of inner area 120 to possess shell region 110
Condition of the permeability more than 2.
Additionally, inner area 120 includes cavity 122, in the present embodiment, cavity 122 is located at inner area
120 interlude.That is, inner area 120 is just filled with material, inner area at relative two ends
120 do not insert material then at middle cavity, and only have air.Certainly, the sky of inner area 120
The position in hole 122 is not limited thereto system with quantity.
Because the length of the implanted magnetic seed 100 of the present embodiment is about 4 millimeters, diameter is about 0.8 millimeter,
Size is fairly small, and when the treatment of hyperplasia of prostate is carried out, implanted magnetic seed 100 only needs fairly small cutting
Mouth just can enter human body through skin penetrating.Also, implanted magnetic seed 100 is being directed to prostate
During, operator can by the inner area 120 of ultrasonic observation implanted magnetic seed 100 cavity 122,
To confirm position of the implanted magnetic seed 100 in human body.
Herein it should be noted that, the purpose in cavity 122 is to allow the ultrasonic wave can to pick out implanted magnetic
Position of the seed 100 in human body, implanted magnetic seed 100 is directed to the ad-hoc location in human body.But
Be be not intended to limit implanted magnetic seed 100 can only be carried out by ultrasonic wave it is image guided in implantation process.
In other embodiments, implanted magnetic seed 100 can also (it can pick out internal gold by computerized tomography
Category material) image be led to the ad-hoc location in human body.
In addition, the above-mentioned size for only listing one of which implanted magnetic seed 100 and one of which cloth pin
Mode, the size of implanted magnetic seed 100 and the mode of cloth pin are not limited thereto system.It is clinical at present to cure
Teacher also proposes two ways to carry out cloth pin that the first is to enter pin from perineum to be implanted into magnetic seed, commonly used
In nuclear species prostate cancer therapy；Second is to enter pin from rectum to be implanted into magnetic seed, is commonly used to ultrasonic wave
Secondary pin puncture cell sampling check.If entering pin from perineum, it is necessary to half body is anaesthetized.If entering pin from rectum, only
Need local anaesthesia.
After implantation is completed, due in the present embodiment, the material of shell region 110 with marquensite system not
Rust steel or ferrite system stainless steel, the material of inner area 120 is by taking non-crystalline material as an example, that is to say, that
The shell region 110 of implanted magnetic seed 100 is all higher than 2 with the relative permeability of inner area 120.If in people
External body imposes additional alternating magnetic field to implanted magnetic seed 100, and magnetic field intensity is about in 0.01G to 1000G
Between, about between 0.1Hz to 1MHz, in one more preferably embodiment, magnetic field intensity is about frequency
100G, between frequency about 1kHz to 100kHz, the shell region 110 and inner area of implanted magnetic seed 100
120 can be produced heat energy by changes of magnetic field, to reach the therapeutic effect of the tissue of heat cure affected part.
Therefore, the implanted magnetic seed 100 of the present embodiment have in implantation and therapeutic process it is simple to operate,
The less advantage of wound that treatment is convenient, caused to patient, patient is in therapeutic process and the pain of post-operative recovery
Bitter degree is relatively low.
It is noted that after the completed treatment, the implanted magnetic seed 100 of the present embodiment can be selected
Take out or do not take out.If not taking out, continue indwelling in affected part, if affected part recurs again thereafter, suffer from
Person can be implanted into again, and indwelling can be used directly in the collocation treatment dress of implanted magnetic seed 100 of affected part
Put to carry out successive treatment, doctor can also be made whether to add other assessments such as new magnetic seed or consider.
In addition, in other embodiments, the shell region 110 of implanted magnetic seed 100 can be that magnesium alloy (can
Degraded metal) or pharmaceutically refer to extraordinary filmogen (such as gelatin, cellulose, polysaccharide, PLA)
The bladder being made, content, (such as medical absorbable relative permeability is more than 2, and size is received 5
Rice to 10 nanometers, 10 nanometers to 20 nanometers, 20 nanometers to 40 nanometers, 30 nanometers to 50 nanometers,
50 nanometers to 100 nanometers and more than 100 nanometers of Nanoscale Iron magnetic magnetic, nanometer ferrimagnetism magnetic and
The nano-magnetic powders such as nanometer superparamagnetism magnetic) according to dosage load wherein (formation inner area 120), it is easy to plant
Enter magnetic strength heating.Implanted magnetic seed 100 as produced by this class material can be absorbed by the body, therefore,
Treatment can take out and voluntarily be absorbed by the body after completing.
Certainly, be only the material of the shell region 110 for enumerating one of which implanted magnetic seed 100 before with it is interior
The combination of the material of heart district 120.In other embodiments, the material of shell region 110 can also be amorphous
Material or Ferrite Material, and the material of inner area 120 can also be marquensite system stainless steel or fertilizer
Grain iron series stainless steel.Similarly, the outer surface of shell region 110 may require that film plating layer 130 (e.g. titanium,
The material of titanium alloy or SUS 316) covering, to provide biocompatibility.
Or, in other embodiments, implanted magnetic seed 100 can also be shell region 110 and inner area
120 are made up of identical material, and for example, whole implanted magnetic seed 100 is that relative permeability is more than 2
(for example select marquensite system stainless steel or ferrite system of the relative permeability between 2 to 1800 stainless
Steel).It is preferred that above-mentioned its relative permeability of single material magnetic seed is tied up between 100 to 1800.
Or, in other embodiments, implanted magnetic seed 100 can also be the relative of shell region 110
Permeability is more than 2, and the relative permeability of inner area 120 is not more than 2.For example, shell region 110
Marquensite system stainless steel, ferrite system stainless steel, non-crystalline material of the selection relative permeability more than 2
Or Ferrite Material.The selection of inner area 120 e.g. SUS316, titanium or titanium alloy (such as Ti6Al4V).
Or, in other embodiments, implanted magnetic seed 100 can also be that the relative of shell region 110 is led
Magnetic rate is not more than 2, and the relative permeability of inner area 120 is more than 2.For example, shell region 110 is selected
Select the good metal of heat conduction efficiency, e.g. titanium, titanium alloy (such as Ti6Al4V) or SUS 316
Affected part is rapidly transferred to Deng, the heat that inner area 120 is produced, inner area 120 may be selected relative leading
Marquensite system stainless steel, ferrite system stainless steel of the magnetic rate more than 2, marquensite system stainless steel, fertile grain
Heat produced by iron series stainless steel magnetic strength, can pass good titanium, titanium alloy or SUS 316 via heat
Heat transfer to tissue is treated.Moreover, inner area 120 may be selected amorphous of the relative permeability more than 2
Material or Ferrite Material, it has preferably poly- magnetic effect, makes script relative permeability outer than relatively low
The material of shell area 110 (such as titanium, titanium alloy or SUS 316) generates heat because of poly- magnetic effect.Can manage
Ferrite is selected in solution, inner area 120, and shell region 110 also can select marquensite system stainless steel or
Ferrite system stainless steel, can make have more preferable heating effect under same magnetic field intensity magnetic strength.
More particularly, for magnetic strength heating effect, marquensite system stainless steel, ferrite system are stainless
Steel is much larger than titanium, titanium alloy or SUS 316, and titanium, titanium alloy or SUS 316 are more than iron again
Ferrite, but with poly- magnetic effect for, Ferrite Material be more than marquensite system stainless steel, ferrite
It is stainless steel, marquensite system stainless steel, ferrite system stainless steel are more than titanium, titanium alloy or SUS again
316, so the heat produced by above-mentioned marquensite system stainless steel, ferrite system stainless steel magnetic strength, Ke Yijing
Good metal is passed by heat and (has biocompatibility again：Titanium, titanium alloy or SUS 316) heat
Tissue is transferred to be treated.If but using Ferrite Material as heart, its function is poly- magnetic, but almost
Will not generate heat, but allow script relative permeability than relatively low housing (titanium, titanium alloy or SUS
316) because poly- magnetic effect cause originally will not, or relatively just generated heat on the contrary under the magnetic field of difficult heating.
So Ferrite Material is to provide the function of induced magnetic field in the present embodiment.For example, if ferrite
Material is arranged in pairs or groups with marquensite system stainless steel (SUS 420, SUS 630), can make marquensite system stainless steel
Heating effect more preferably (under same magnetic field intensity heating effect more preferably, or under relatively low magnetic field intensity just
Heating standard can be reached).If Ferrite Material and austenite iron series stainless steel (SUS 304, SUS 316)
Collocation, can make austenite iron series stainless steel not generated heat originally under same magnetic field intensity and be turned into and can generate heat.
No matter the relative permeability of the shell region 110 of above-mentioned implanted magnetic seed 100 and inner area 120
Which kind of combination relative permeability is, when imposing additional alternating magnetic field, implanted outside implanted magnetic seed 100
The shell region 110 of magnetic seed 100 can be produced heat energy with least one of inner area 120 by changes of magnetic field,
To reach the therapeutic effect of the tissue of heat cure affected part.
Fig. 3 is the schematic diagram according to a kind of implanted magnetic seed of another embodiment of the present invention.Refer to figure
3, the implanted magnetic seed 200 of the present embodiment exists with the Main Differences of the implanted magnetic seed 100 of previous embodiment
In, in the present embodiment, the whole inner area 220 of implanted magnetic seed 200 is all cavity 222, and not
Insert material.In the present embodiment, the relative permeability of shell region 210 is more than 2, for example, outward
Shell area 210 selects marquensite system's stainless steel or ferrite system stainless steel.It is relative due to shell region 210
Permeability is more than 2, when imposing additional alternating magnetic field, implanted magnetic seed 200 outside implanted magnetic seed 200
Shell region 210 can by changes of magnetic field and produce heat energy, to reach the therapeutic effect of heat cure affected tissue.
Similarly, the outer surface of shell region 210 may require that film plating layer 230 (e.g. titanium, titanium alloy or such as
The material of SUS316) covering, to provide biocompatibility.In other application, shell region 210 also may be used
Non-crystalline material (relative permeability is about 200) or ferrite material from relative permeability more than 2
Material, and suitable magnetic field intensity of arranging in pairs or groups, remain to magnetic strength and heat.
Fig. 4 is the schematic diagram according to a kind of implanted magnetic seed of another embodiment of the present invention.Refer to figure
4, the implanted magnetic seed 300 of the present embodiment is with one of difference of the implanted magnetic seed 100 of Fig. 2,
In the present embodiment, the relative permeability of a portion of the shell region 310 of implanted magnetic seed 300 is big
In 2, and the relative permeability of another part of shell region 310 is less than 2.More particularly, shell region
310 include two Part I 312 and Part II 314, and two Part I 312 are located at shell region
310 opposite end, Part II 314 is located at the interlude of shell region 310, Part I 312
Relative permeability is more than 2, and the relative permeability of Part II 314 is less than 2.That is, shell region
310 only subregions are made by the material as relative permeability more than 2.
When affected part region is smaller or to carry out heat cure for specific cell block, the present embodiment can be used
Implanted magnetic seed 300, because the shell region 310 of the implanted magnetic seed 300 of the present embodiment is not whole
Material by relative permeability more than 2 makes, when imposing additional alternation magnetic outside implanted magnetic seed 300
, only in Part I 312, (relative permeability is more than 2 for the shell region 310 of implanted magnetic seed 300
Region) heat energy can be produced by changes of magnetic field, and heat only is carried out to the tissue near Part I 312
Treatment.
In addition, another of the implanted magnetic seed 100 of the implanted magnetic seed 300 of the present embodiment and Fig. 2 is poor
It is different to be, in the present embodiment, shell region 310 (including Part I 312 and Part II 314)
Material is the material with biocompatibility, therefore, implanted magnetic seed 300 can be not required to film plating layer and set
Put the outer surface in shell region 310.
Additionally, in order to more clearly represent the implanted produced using the material of different relative permeabilities
Magnetic seed produces the situation of heat energy after being influenceed by externally-applied magnetic field.Below by with the implanted magnetic seed of Fig. 1
(partly with the implanted magnetic seed of Fig. 3 as a example by the form of 100 (including shell region 110 and inner areas 120)
200, whole inner area 220 is cavity 222, as a example by only shell region 210 is entity), for outer
Shell area 110 and the material of inner area 120 are replaced by material of the relative permeability less than 2, relative lead respectively
The multiple combination of the material of magnetic rate more than 2 is simulated.
Fig. 5 A to Fig. 5 H are to impose magnetic field to the implanted magnetic seed as produced by different materials respectively and produce
The simulation schematic diagram of heat energy.In the simulation of Fig. 5 A to Fig. 5 H, the implanted magnetic seed 100 of use
Length is about 4 millimeters, and diameter is about 0.8 millimeter, and the thickness of shell region 110 is about 0.1 millimeter to 0.4
Millimeter, the intensity of externally-applied magnetic field is 0.001G to 1000G, and simulation can reach 60 and take the photograph in about 1 minute
Family name's degree, device frequency is 0.1Hz to 1MHz, and the thickness of film plating layer 130 is about at 0.01 millimeter to 0.1
Between millimeter, for example the thickness of film plating layer 130 is with 0.08 millimeter.Color is deeper on drawing represents temperature more
Height, the engineer's scale of drawing right is may be referred on the temperature representated by color depth.Due to can allow
The temperature of protein denaturation is approximately 60 degrees Celsius, in this simulation, will be so that whether can to reach 60 Celsius
It is standard to spend.From analog result, film plating layer 130 will not cause other influences to analog result.Under
Face will illustrate the result of simulation.
It is please control group referring initially to Fig. 5 A and Fig. 5 B, Fig. 5 A and Fig. 5 B, in detail, Fig. 5 A are
Whole implanted magnetic seed (including shell region and inner area) is to use material of the relative permeability less than 2
The result for being simulated.The shell region of the implanted magnetic seed of Fig. 5 B is to use material of the relative permeability less than 2
Material is not inserted in material, inner area, that is, whole inner area is all the result that cavity is simulated.By
Fig. 5 A and Fig. 5 B understand that both are to use the plant produced by material of the relative permeability less than 2
Enter the demand that formula magnetic seed is unable to reach 60 degrees Celsius.
Fig. 5 C are that the shell region of implanted magnetic seed is material of the relative permeability more than 2, and inner area is with amorphous
The result that matter, Ferrite Material are simulated.From analog result, around implanted magnetic seed 100
About 4.2 millimeters of length, radially 1.2 millimeters of scope can reach 60 degrees Celsius.
Fig. 5 D are that the shell region and inner area of implanted magnetic seed are all material institute of the relative permeability more than 2
The result for simulating.From analog result, about 4.6 millimeters of the length around implanted magnetic seed, radially
1.2 millimeters of scope can reach 60 degrees Celsius.
Fig. 5 E are that the shell region of implanted magnetic seed is material of the relative permeability more than 2, and inner area is not filled out
Enter material, that is, similar to the embodiment of Fig. 3, whole inner area is all the result that cavity is simulated.
From analog result, about 4.4 millimeters of the length around implanted magnetic seed, radially 1.0 millimeters of scope energy
Enough reach 60 degrees Celsius.
Fig. 5 F are that the shell region of implanted magnetic seed is material of the relative permeability more than 2, and inner area is relative
The result that material of the permeability less than 2 is simulated.From analog result, around implanted magnetic seed
About 4.5 millimeters of length, radially 1.1 millimeters of scope can reach 60 degrees Celsius.
Fig. 5 G are that the shell region of implanted magnetic seed is material of the relative permeability less than 2, and inner area is phase
The result that material to permeability more than 2 is simulated.From analog result, in implanted magnetic seed week
About 6 millimeters of length is enclosed, radially 4 millimeters of scope can reach 60 degrees Celsius.Fig. 5 H are implanted magnetic
The shell region of seed is material of the relative permeability less than 2, and inner area is noncrystalline, ferritic material institute
The result for simulating.From analog result, about 5.2 millimeters of the length around implanted magnetic seed, radially
3.4 millimeters of scope can reach 60 degrees Celsius.
But be may know that from the analog result of Fig. 5 A to Fig. 5 H, as long as implanted magnetic seed 100,200
Shell region 110,210 uses material of the relative permeability more than 2 with least one of inner area 120,220
Material, can reach 60 degrees Celsius of temperature under the influence of externally-applied magnetic field, and can be to the tissue of surrounding
Carry out heat cure.
Fig. 6 and Fig. 7 is the schematic diagram according to a kind of implanted magnetic seed of another embodiment of the present invention.Please
Referring initially to Fig. 6 and Fig. 7, the implanted magnetic seed 400,500 of Fig. 6, Fig. 7 and the implanted magnetic seed of Fig. 2
100 Main Differences are that the surface of the shell region 410,510 of implanted magnetic seed 400,500 has figure
Line, the surface of the shell region 110 of the implanted magnetic seed 100 of Fig. 2 is smooth surface.In figure 6, plant
Entering the surface of the shell region 410 of formula magnetic seed 400 has the protuberance 416 of multiple spirals (i.e. the figure line is
Protuberance 416).In the figure 7, the surface of the shell region 510 of implanted magnetic seed 500 has multiple spirals
Chase 518 (i.e. the figure line be chase 518).
In the embodiment of Fig. 6 and Fig. 7, implanted magnetic seed 400,500 passes through shell region 410,510
Surface there is protuberance 416 and chase 518 to produce the surface of out-of-flatness respectively, consequently, it is possible to
Implanted magnetic seed 400,500 can relatively be firmly secured in the tissue of human body without coming off easily or
It is moved to the position beyond affected part.
It should be noted that, although in figs. 6 and 7, protuberance 416 and chase 518 are spirally
Mode be regularly arranged on the surface of shell region 410,510, but in other embodiments, protuberance
416 can not also be spirally with chase 518 form present, or protuberance 416 and chase 518
Can also brokenly arrange, the quantity of protuberance 416 and chase 518, cross sectional shape and distribution
Position is not intended to limit.In addition, compared to smooth surface, the out-of-flatness of shell region can also lift magnetic
The vortex of seed damages intensity, and the heating to magnetic seed is helpful.
Fig. 8 is the generalized section according to a kind of implanted magnetic seed of another embodiment of the present invention.Please join
Fig. 8 is read, the implanted magnetic seed 600 of the present embodiment exists with the Main Differences of the implanted magnetic seed 100 of Fig. 2
In, in the embodiment of fig. 2, the inner area 120 of implanted magnetic seed 100 only has single cavity 122,
And the position in this cavity 122 is located at the interlude of inner area 120.In the present embodiment, inner area 620
Including unconnected multiple cavities 622.More particularly, inner area 620 includes two cavities 622, its
In cavity 622 be to be located at the interlude of inner area 620 and the position wherein between one end, another
Cavity 622 is the position being located between the interlude of inner area 620 and the other end.
Although the inner area 120 of the implanted magnetic seed 100 of Fig. 2 has the single design in cavity 122
Can make operator that the position of implanted magnetic seed 100 is known by way of ultrasonic wave, but due to planting
Enter formula magnetic seed 100,600 and strip similar to capsule is presented, in order to make operator by implanted
Magnetic seed 100,600 is more accurately located during being directed to affected part, e.g. knows implanted magnetic seed
100th, 600 orientation (or that angle of implanted magnetic seed 100,600), in the present embodiment, plants
Enter formula magnetic seed 600 by designing two cavities 622 in area 620 at heart, operator can be by ultrasonic wave
Mode observe two cavities 622, just can for example, by be with two directions of the line in cavity 622,
Simply judge 600 orientation generally of implanted magnetic seed.
It is noted that in other embodiments, the two of the inner area 620 of implanted magnetic seed 600 are empty
The position in hole 622 can also be two ends or the other positions for being located at inner area 620, and designer visually needs
Ask the voluntarily quantity in the cavity 622 of the inner area 620 of adjustment implanted magnetic seed 600 and position, implanted
The quantity in the cavity 622 of the inner area 620 of magnetic seed 600 is with position also not with the above-mentioned system that is limited.
In addition, although the shape of above-mentioned implanted magnetic seed 100,200,300,400,500,600 is
By taking the strip similar to capsule as an example, but implanted magnetic seed 100,200,300,400,500,
600 can also be spherical, egg type or other kind of shape, implanted magnetic seed 100,200,300,400,
500th, 600 shape is not limited thereto system.
In sum, implanted magnetic seed of the invention is suitable for application in temporary transient formula or Yong Liushi organizes heat to control
Treatment technology, as used in the treatment of hyperplasia of prostate, during implantation, implanted magnetic seed can lead to example
Ultrasonic observation to the cavity of inner area is crossed, to confirm position of the implanted magnetic seed in human body.It has been implanted into
After, because implanted magnetic seed is in the phase of shell region and at least one of inner area at least regional area
2 are more than to permeability, if imposing additional alternating magnetic field to implanted magnetic seed, implanted magnetic seed is led relative
Region of the magnetic rate more than 2 can produce the tissue of heat energy and heat cure affected part, to reach the effect for the treatment of.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than right
Its limitation；Although being described in detail to the present invention with reference to foregoing embodiments, this area it is common
Technical staff should be understood：It can still modify to the technical scheme described in foregoing embodiments,
Or equivalent is carried out to which part or all technical characteristic；And these modifications or replacement, and
The scope of the essence disengaging various embodiments of the present invention technical scheme of appropriate technical solution is not made.
Claims (12)
1. a kind of implanted magnetic seed, it is characterised in that including：
Shell region；And
Inner area, is surrounded by the shell region, the inner area include cavity, wherein the shell region with
The relative permeability of at least regional area of at least one of the inner area is more than 2.
2. implanted magnetic seed according to claim 1, it is characterised in that the shell region it is relative
Permeability is more than 2, and the inner area is non-crystalline material or Ferrite Material.
3. implanted magnetic seed according to claim 1, it is characterised in that the shell region is amorphous
Material or Ferrite Material, and the relative permeability of the inner area is more than 2.
4. implanted magnetic seed according to claim 1, it is characterised in that the shell region with it is described
The relative permeability of inner area is all more than 2, and the shell region is made up of with the inner area identical material.
5. implanted magnetic seed according to claim 1, it is characterised in that the shell region it is relative
Permeability is more than 2, and the inner area is the cavity.
6. implanted magnetic seed according to claim 1, it is characterised in that the shell region it is relative
Permeability is more than 2, and the relative permeability of the inner area is less than or equal to 2.
7. implanted magnetic seed according to claim 1, it is characterised in that the shell region it is relative
Permeability is less than or equal to 2, and the relative permeability of the inner area is more than 2.
8. implanted magnetic seed according to claim 1, it is characterised in that the first of the shell region
Partial relative permeability is more than 2, and the relative permeability of the Part II of the shell region is less than or equal to
2。
9. implanted magnetic seed according to claim 1, it is characterised in that the surface of the shell region
With figure line, the figure line is chase or protuberance.
10. implanted magnetic seed according to claim 1, it is characterised in that the inner area includes
Unconnected multiple cavities.
11. implanted magnetic seeds according to claim 1, it is characterised in that the shell region and institute
The material for stating inner area is all material of the degradable and relative permeability more than 2.
12. implanted magnetic seeds according to claim 1, it is characterised in that also include：
Film plating layer, is covered in the outer surface of the shell region, wherein the material of the film plating layer is with life
The material of thing compatibility.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510856602.1A CN106806014A (en) | 2015-11-30 | 2015-11-30 | Implanted magnetic seed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510856602.1A CN106806014A (en) | 2015-11-30 | 2015-11-30 | Implanted magnetic seed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106806014A true CN106806014A (en) | 2017-06-09 |
Family
ID=59155787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510856602.1A Pending CN106806014A (en) | 2015-11-30 | 2015-11-30 | Implanted magnetic seed |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111449830A (en) * | 2020-04-08 | 2020-07-28 | 苏州大学 | Application of implantable metal as accurate and efficient tumor magnetic heat treatment reagent |
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|---|---|---|---|---|
| US6074337A (en) * | 1997-05-28 | 2000-06-13 | Ablation Technologies, Inc. | Combination radioactive and temperature self-regulating thermal seed implant for treating tumors |
| US6497647B1 (en) * | 2001-07-18 | 2002-12-24 | Ati Medical, Inc. | Radiation and thermal energy source |
| US6993394B2 (en) * | 2002-01-18 | 2006-01-31 | Calfacion Corporation | System method and apparatus for localized heating of tissue |
| CN101460102A (en) * | 2006-10-05 | 2009-06-17 | 德国pfm医用商品有限责任公司 | Implantable device |
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2015
- 2015-11-30 CN CN201510856602.1A patent/CN106806014A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6074337A (en) * | 1997-05-28 | 2000-06-13 | Ablation Technologies, Inc. | Combination radioactive and temperature self-regulating thermal seed implant for treating tumors |
| US6497647B1 (en) * | 2001-07-18 | 2002-12-24 | Ati Medical, Inc. | Radiation and thermal energy source |
| US6993394B2 (en) * | 2002-01-18 | 2006-01-31 | Calfacion Corporation | System method and apparatus for localized heating of tissue |
| CN101460102A (en) * | 2006-10-05 | 2009-06-17 | 德国pfm医用商品有限责任公司 | Implantable device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111449830A (en) * | 2020-04-08 | 2020-07-28 | 苏州大学 | Application of implantable metal as accurate and efficient tumor magnetic heat treatment reagent |
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Application publication date: 20170609 |