CN106798756A - For the extraction process of Ligusticum wallichii active ingredient in beneficial female biochemistry mixture - Google Patents
For the extraction process of Ligusticum wallichii active ingredient in beneficial female biochemistry mixture Download PDFInfo
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- CN106798756A CN106798756A CN201710123991.6A CN201710123991A CN106798756A CN 106798756 A CN106798756 A CN 106798756A CN 201710123991 A CN201710123991 A CN 201710123991A CN 106798756 A CN106798756 A CN 106798756A
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- Prior art keywords
- ligusticum wallichii
- active ingredient
- ethanol
- soak
- concentration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses the extraction process for Ligusticum wallichii active ingredient in beneficial female biochemistry mixture；It is in the prior art to carry out mixing extraction to different medicinal materials using identical extracting method to solve, and causes the extraction effect of effective ingredient in various medicinal materials to differ, and in turn results in the problem of the significant wastage of raw material.Ligusticum wallichii is broken into the particle that particle diameter is 1~3mm by the present invention including (1)；(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time is 2~4h, and then adding distilled water makes the concentration of ethanol reach 75%~80%, is further continued for 16~20h of immersion；(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and ethanol obtains extract solution after reclaiming；(4) after using distillation water washing extract solution, filtering obtains the active ingredient of Ligusticum wallichii after re-dry concentration.The present invention has the advantages that high income, efficiency high, good drug efficacy.
Description
Technical field
The present invention relates to a kind of extracting method, and in particular to for the extraction work of Ligusticum wallichii active ingredient in beneficial female biochemistry mixture
Skill.
Background technology
Beneficial female biochemistry mixture by motherwort, Radix Angelicae Sinensis, Ligusticum wallichii, peach kernel, baked ginger, Radix Glycyrrhizae (processing) above Six-element medicinal material processing and
Into.There is promoting blood circulation, antalgic, be mainly used in treatment disease that postpartum lochia can't go, abdominal pain due to blood stasis.It is greenish orange yellow
To brown color liquid.Gas is fragrant, and taste is micro- sweet.The female biochemistry mixture of the benefit is mainly used in the livestocks such as horse, ox, sheep, pig, wherein horse, Niu Yong
It is 200-300mL to measure, and sheep, pig consumption are 30-50mL.
The preparation method of the female biochemistry mixture of the benefit is disclosed in the prior art, is after various medicinal materials are mixed, using water
Pan-fried method is concentrated after extracting, in the conventional method, because the active principle of medicinal material is different, required condition during leaching
Also differ, using identical decocting temperature and leaching condition, cause the extraction effect of effective ingredient in various medicinal materials to differ, lead
Cause wastage of material.And during decocting, because temperature is too high, the property of medicine partial loss of active ingredient is easily caused, and then influence medicine
Effect.
The content of the invention
The technical problems to be solved by the invention are：It is in the prior art to different medicinal materials using identical extracting method
Mixing extraction is carried out, cause the extraction effect of effective ingredient in various medicinal materials to differ, the significant wastage in turn resulting in raw material is asked
Topic, it is therefore intended that the extraction process for Ligusticum wallichii active ingredient in beneficial female biochemistry mixture for solving the above problems is provided.
The present invention is achieved through the following technical solutions：
For the extraction process of Ligusticum wallichii active ingredient in beneficial female biochemistry mixture, including：
(1) Ligusticum wallichii is broken into the particle that particle diameter is 1~3mm；
(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time is 2
~4h, then adding distilled water makes the concentration of ethanol reach 75%~80%, is further continued for 16~20h of immersion；
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and ethanol obtains extract solution after reclaiming；
(4) after using distillation water washing extract solution, filtering obtains the active ingredient of Ligusticum wallichii after re-dry concentration.
The invention provides a kind of method of the extracts active ingredients of the Ligusticum wallichii suitable for beneficial female biochemistry mixture, in the method
Medicinal material is extracted using the extract solution time segment of two kinds of various concentrations, can be maximized by Ligusticum wallichii by the method
Extracts active ingredients out, and then improve extraction efficiency, and economize in raw materials cost.
In order to be able to while drug effect is ensured, effectively improve extraction efficiency and extract yield, it is preferable that the step (2)
The temperature of middle immersion is 35~40 DEG C, in immersion process and is stirred；The speed of the stirring is 6~30r/min.
In order to preferably discharge impurity, and effectively reduce concentration time, it is to avoid the drug effect of active ingredient, institute after influence concentration
The addition for stating distilled water when step (4) is middle to wash is identical with the volume of extract solution.
The present invention compared with prior art, has the following advantages and advantages：
By optimization design of the invention, make the yield of extraction higher, extraction in hgher efficiency, and can better ensure that
The drug effect of the active ingredient for extracting, effect is very notable.
Specific embodiment
To make the object, technical solutions and advantages of the present invention become more apparent, with reference to embodiment, the present invention is made
Further to describe in detail, exemplary embodiment of the invention and its explanation are only used for explaining the present invention, are not intended as to this
The restriction of invention.
Embodiment 1
For the extraction process of Ligusticum wallichii active ingredient in beneficial female biochemistry mixture, including：
(1) Ligusticum wallichii is broken into the particle that particle diameter is 2~2.5mm.
(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time is
3h, then adding distilled water makes the concentration of ethanol reach 78%, is further continued for soaking 18h；The temperature of the immersion is in this step
38~40 DEG C, and need to be stirred in immersion process, the speed of stirring is preferably 20r/min.
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and heating bath temperature is 60 DEG C, and ethanol is obtained after reclaiming
Obtain extract solution.
(4) using being washed to extract solution with the distilled water of extract solution same volume, filter, then using low temperature drying skill
Art carries out concentrate drying to filtered fluid, and the active ingredient of Ligusticum wallichii is obtained after drying.
By detection, the active ingredient of the Ligusticum wallichii accounts for the 6.3% of Ligusticum wallichii gross mass.
Embodiment 2
The present embodiment is the comparative examples of embodiment 1, and the solution soaked in the present embodiment is different, specific to set as follows：
(1) Ligusticum wallichii is broken into the particle that particle diameter is 2~2.5mm.
(2) particle is placed in soaking container, uses concentration to be soaked for 80% ethanol, soak time is 20h；This
The temperature of the immersion is 38~40 DEG C in step, and need to be stirred in immersion process, and the speed of stirring is preferably 20r/
min。
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and heating bath temperature is 60 DEG C, and ethanol is obtained after reclaiming
Obtain extract solution.
(4) using being washed to extract solution with the distilled water of extract solution same volume, filter, then using low temperature drying skill
Art carries out concentrate drying to filtered fluid, and the active ingredient of Ligusticum wallichii is obtained after drying.
By detection, the active ingredient of the Ligusticum wallichii accounts for the 4.6% of Ligusticum wallichii gross mass.
Embodiment 3
The present embodiment is the comparative examples of embodiment 1, and the solution soaked in the present embodiment is different, specific to set as follows：
(1) Ligusticum wallichii is broken into the particle that particle diameter is 2~2.5mm.
(2) particle is placed in soaking container, uses concentration to be soaked for 80% ethanol, soak time is 40h；This
The temperature of the immersion is 20~25 DEG C in step, and need to be stirred in immersion process, and the speed of stirring is preferably 20r/
min。
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and heating bath temperature is 60 DEG C, and ethanol is obtained after reclaiming
Obtain extract solution.
(4) using being washed to extract solution with the distilled water of extract solution same volume, filter, then using low temperature drying skill
Art carries out concentrate drying to filtered fluid, and the active ingredient of Ligusticum wallichii is obtained after drying.
By detection, the active ingredient of the Ligusticum wallichii accounts for the 4.8% of Ligusticum wallichii gross mass.
Embodiment 4
The present embodiment is the comparative examples of embodiment 1, and the solution soaked in the present embodiment is different, specific to set as follows：
(1) Ligusticum wallichii is broken into the particle that particle diameter is 1.8~2.3mm.
(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time is
6h, then adding distilled water makes the concentration of ethanol reach 85%, is further continued for soaking 18h；The temperature of the immersion is in this step
35~40 DEG C, and need to be stirred in immersion process, the speed of stirring is preferably 20r/min.
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and heating bath temperature is 60 DEG C, and ethanol is obtained after reclaiming
Obtain extract solution.
(4) using being washed to extract solution with the distilled water of extract solution same volume, filter, then using low temperature drying skill
Art carries out concentrate drying to filtered fluid, and the active ingredient of Ligusticum wallichii is obtained after drying.
By detection, the active ingredient of the Ligusticum wallichii accounts for the 5.7% of Ligusticum wallichii gross mass.
Above-described specific embodiment, has been carried out further to the purpose of the present invention, technical scheme and beneficial effect
Describe in detail, should be understood that and the foregoing is only specific embodiment of the invention, be not intended to limit the present invention
Protection domain, all any modification, equivalent substitution and improvements within the spirit and principles in the present invention, done etc. all should include
Within protection scope of the present invention.
Claims (5)
1. the extraction process of Ligusticum wallichii active ingredient in the female biochemistry mixture of benefit is used for, it is characterised in that including：
(1) Ligusticum wallichii is broken into the particle that particle diameter is 1~3mm；
(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time is 2~4h,
Then adding distilled water makes the concentration of ethanol reach 75%~80%, is further continued for 16~20h of immersion；
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and ethanol obtains extract solution after reclaiming；
(4) after using distillation water washing extract solution, filtering obtains the active ingredient of Ligusticum wallichii after re-dry concentration.
2. the extraction process for Ligusticum wallichii active ingredient in beneficial female biochemistry mixture according to claim 1, it is characterised in that
The concentration that dries in the step (4) uses low temperature drying method.
3. the extraction process for Ligusticum wallichii active ingredient in beneficial female biochemistry mixture according to claim 1, it is characterised in that
The temperature of immersion is 35~40 DEG C in the step (2), in immersion process and is stirred.
4. the extraction process for Ligusticum wallichii active ingredient in beneficial female biochemistry mixture according to claim 3, it is characterised in that
The speed of the stirring is 6~30r/min.
5. the extraction process for Ligusticum wallichii active ingredient in beneficial female biochemistry mixture according to claim 1, it is characterised in that
The addition of distilled water is identical with the volume of extract solution during washing in the step (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710123991.6A CN106798756A (en) | 2017-03-03 | 2017-03-03 | For the extraction process of Ligusticum wallichii active ingredient in beneficial female biochemistry mixture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710123991.6A CN106798756A (en) | 2017-03-03 | 2017-03-03 | For the extraction process of Ligusticum wallichii active ingredient in beneficial female biochemistry mixture |
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|---|---|
| CN106798756A true CN106798756A (en) | 2017-06-06 |
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| CN201710123991.6A Pending CN106798756A (en) | 2017-03-03 | 2017-03-03 | For the extraction process of Ligusticum wallichii active ingredient in beneficial female biochemistry mixture |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1580049A (en) * | 2003-07-31 | 2005-02-16 | 深圳市泰康制药有限公司 | Method for extracting total phenyl phthalein of ligusitcum wallichii |
| US20060068045A1 (en) * | 2002-08-20 | 2006-03-30 | Yong Eu L | Method for the preparation of phytoprogestogenic extracts from rhizoma ligusticum chuanxiong and uses thereof |
| CN102872175A (en) * | 2012-08-24 | 2013-01-16 | 天津中医药大学 | Ligusticum chuanxiong hort extract and preparation method and application thereof |
-
2017
- 2017-03-03 CN CN201710123991.6A patent/CN106798756A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060068045A1 (en) * | 2002-08-20 | 2006-03-30 | Yong Eu L | Method for the preparation of phytoprogestogenic extracts from rhizoma ligusticum chuanxiong and uses thereof |
| CN1580049A (en) * | 2003-07-31 | 2005-02-16 | 深圳市泰康制药有限公司 | Method for extracting total phenyl phthalein of ligusitcum wallichii |
| CN102872175A (en) * | 2012-08-24 | 2013-01-16 | 天津中医药大学 | Ligusticum chuanxiong hort extract and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郑雅楠: "通脉滴丸的制备工艺和质量标准研究", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
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Application publication date: 20170606 |