CN106729991A - A kind of segmentation coating for body implanting material - Google Patents
A kind of segmentation coating for body implanting material Download PDFInfo
- Publication number
- CN106729991A CN106729991A CN201611029883.4A CN201611029883A CN106729991A CN 106729991 A CN106729991 A CN 106729991A CN 201611029883 A CN201611029883 A CN 201611029883A CN 106729991 A CN106729991 A CN 106729991A
- Authority
- CN
- China
- Prior art keywords
- hap
- coating
- gelatin
- solution
- segmentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/04—Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The invention discloses a kind of segmentation coating process for body implanting material, including fimbrin preparation method and gelatin/HAp coatings;The method is implanted into the biocompatibility issues of material and product generally existing for clinical biochemical, improves the surface component and pattern of biological implantation material, can effectively improve histocompatbility.It is a kind of effective coating process that can be applied to biological implantation material surface.Advantage of the invention is that compared to the single coating mode of conventional medical material surface, segmentation coating structure can be directed to different human body position, the biocompatibility of effective enhancing implant;Segmentation coating can further improve the bioactivity of implant and organizational interface, improve fusion rate, reach biology fusion;Preparation method is simple and easy to apply, with low cost, for industrialization provides facility.
Description
Technical field
The present invention relates to one kind segmentation coating process, and in particular to a kind of segmentation coating side for body implanting material
Method, the method can solve the problem that the different parts in body implanting material add different growth factors or meet different physiological functions
Demand.This method belongs to technical field of biological material, can be widely applied to the face coat of tissue renovation material.
Background technology
The surface component and pattern of biological implantation material biomechanical property often to material and its with host tissue
Biocompatibility has a great impact.For biological implantation material and product generally existing biocompatibility in terms of deficiency,
Have developed the coating material that biocompatibility is excellent, can be applied to biological implantation material surface.It is that one kind can be applied to towards bone
The crucial technology of preparing of effective coating material of joint repair material surface.
Traditional single metal material and macromolecular material exist poor biocompatibility and tissue combine it is insecure,
The shortcomings of adverse reaction may occurring under the effect of body physiological factor.Reason is that fibroblast and synovial cell cannot close
Section chamber superficial growth and effectively parcel are implanted into material and cause its inducing self-body tissue growth, and ultimately result in the abrasion of implant
And fatigue fracture, its particle for coming off causes the complication such as synovitis.
The common problem in operation, is the synosteosis ability of graft and host, it is impossible to reach physiology at present
Healing, causes operative failure rate high.Compared to the pattern of existing medical material surface single coating, built by material surface and received
Meter level gelatin/hydroxyapatite(HAp), the organo-mineral complexing coating such as fibroin, implant biology in vivo and in vitro can be strengthened
Compatibility simultaneously promotes the growth of bone and soft tissue, effectively reduces the risk of operative failure.The present invention is directed to human synovial
The different healing in position requires to carry out segmentation coating to new implantation material, further increases the life of implant and bone interface
Thing activity, improves fusion rate, has reached more preferable biology syncretizing effect.
The content of the invention
The present invention in view of the shortcomings of the prior art, has invented a kind of segmentation coating process for body implanting material.Should
Method is implanted into the biocompatibility issues of material and product generally existing for clinical biochemical, further improves biological implantation material
The surface component and pattern of material, can effectively improve histocompatbility.It is that a kind of can be applied to biological implantation material surface
Effective coating process.
To realize such purpose, the present invention is achieved through the following technical solutions.
A kind of segmentation coating process for body implanting material, it is characterised in that comprise the following steps:
(1)Fimbrin preparation method
A kind of polymer biological implantation material is dipped in 30min, ultrasonically treated 5min in absolute ethyl alcohol, surface impurity is removed, taken
It is cleaned multiple times to remove residual ethanol with distilled water after going out, ultrasound 3 times, each 5min is subsequently placed in drying in 60 DEG C of baking ovens;
Silk fibroin powder is dissolved in three distilled water so that its concentration is 1wt%-4wt%, and above-mentioned polymer biological is planted
Enter material to be immersed in the silk fibroin solution, kept for 4 DEG C, 12h takes out and dried in 60 DEG C of baking ovens, is then again placed in the material
30min is soaked in absolute ethyl alcohol, 60 DEG C of oven dryings after taking-up;
(2)Gelatin/HAp coatings
At 50 DEG C -60 DEG C, gelatin is dissolved in deionized water, mass concentration is 2%-10%, magnetic agitation treats that gelatin is completely molten
Xie Hou, balance weighs HAp, adds gelatin solution so that the final concentration of 0.1-1wt% of HAp;
The material that coating will be segmented is soaked in sodium hydroxide solution, is taken out after 2 hours, is cleaned with a large amount of distilled water, until
PH value is neutrality, is placed in 60 DEG C of oven dryings, obtains polymeric material of the surface with carboxyl;The segmentation material is immersed in
State in HAp solution, ultrasonically treated 15 minutes, slowly lift out from solution, 40 DEG C of kept dries;
It is that can obtain while having fibroin and HAp to be segmented the biomaterial of coating by above-mentioned steps permutation and combination.
Given birth to because fibroin albumen has excellent biocompatibility, nontoxic, non-stimulated, non-immunogenicity and promotees cell in vivo
Effect long.Therefore it is introduced into for biomaterial coating.Because HAp is main inorganic constituents in humans and animals bone,
There is inducing osteoblast, promote Osteoblast Differentiation, propagation and calcium deposition, so as to strengthen the formation of new bone.Therefore will
The coating is introduced into biomaterial the segmentation position for needing Bone formation.
The method is implanted into the biocompatibility issues of material and product generally existing for clinical biochemical, improves biological plants
Enter the surface component and pattern of material, can effectively improve histocompatbility.It is that one kind can be applied to biological implantation material table
Effective coating process in face.
Advantage of the invention is that:(1)Compared to the single coating mode of conventional medical material surface, coating structure energy is segmented
Enough it is directed to different human body position, the biocompatibility of effective enhancing implant;(2)Segmentation coating can further improve implantation
Thing and the bioactivity of organizational interface, improve fusion rate, reach biology fusion;(3)Preparation method is simple and easy to apply, low cost
It is honest and clean, for industrialization provides facility.
Brief description of the drawings
Fig. 1 is the fibroin coating on PET surface;
Fig. 2 is the gelatin/hydroxyapatite coating layer on PET surface.
Specific embodiment
Technical scheme is further described below by way of specific embodiment.Following embodiment is to this
That invents further illustrates, and does not limit the scope of the invention.
Embodiment 1
1st, fimbrin preparation method
By polyethylene terephthalate(PET)Material is dipped in 30min in absolute ethyl alcohol, ultrasonically treated 5min, removes surface
Impurity, is cleaned multiple times to remove residual ethanol after taking-up with distilled water, and ultrasonic 3 times, each 5min is subsequently placed in 60 DEG C of baking ovens
Drying.
PET material is soaked in sodium hydroxide solution again, is taken out after 2 hours, cleaned with a large amount of distilled water, until pH value
It is neutrality, is placed in 60 DEG C of oven dryings, obtains PET material of the surface with carboxyl.
Silk fibroin powder is dissolved in three distilled water so that its concentration is 2wt%.By the biological implantation materials of above-mentioned PET
Material is immersed in the silk fibroin solution, keeps 4 DEG C, 12h.Take out and dried in 60 DEG C of baking ovens.Then the material is placed in again anhydrous
30min is soaked in ethanol, is taken out after 60 DEG C of oven dryings.
2nd, gelatin/HAp coatings
(1)At 50 DEG C -60 DEG C, gelatin is dissolved in deionized water, mass concentration is 5wt%, magnetic agitation treats that gelatin is complete
After dissolving, balance weighs HAp, adds gelatin solution so that the final concentration of 0.12wt% of HAp
(2)The material of fibroin coating will be completed in 1, wherein needing the portion of material for being segmented coating to be immersed in 2(1)HAp
In solution, ultrasonically treated 15 minutes, slowly lift out from solution, 40 DEG C of kept dries.
There is fibroin and HAp to be segmented the biomaterial of coating simultaneously.
Embodiment 2
1st, fimbrin preparation method
By polyethylene(PE)Material is dipped in 30min in absolute ethyl alcohol, ultrasonically treated 5min, removes surface impurity, with steaming after taking-up
Distilled water is cleaned multiple times to remove residual ethanol, and ultrasound 3 times, each 5min is subsequently placed in drying in 60 DEG C of baking ovens.
PE materials are soaked in sodium hydroxide solution again, are taken out after 2 hours, cleaned with a large amount of distilled water, until pH value
It is neutrality, is placed in 60 DEG C of oven dryings, obtains PE material of the surface with carboxyl.
Silk fibroin powder is dissolved in three distilled water so that its concentration is 3wt%.By the biological implantation materials of above-mentioned PE
Material is immersed in the silk fibroin solution, keeps 4 DEG C, 12h.Take out and dried in 60 DEG C of baking ovens.Then the material is placed in again anhydrous
30min is soaked in ethanol, 60 DEG C of oven dryings after taking-up.
2nd, gelatin/HAp coatings
(1)At 50 DEG C -60 DEG C, gelatin is dissolved in deionized water, mass concentration is 2%, magnetic agitation, treats that gelatin is completely molten
Xie Hou, balance weighs HAp, adds gelatin solution so that the final concentration of 0.2wt% of HAp
(2)The material of fibroin coating will be completed in 1, wherein needing the portion of material for being segmented coating to be immersed in 2(1)HAp
In solution, ultrasonically treated 15 minutes, slowly lift out from solution, 40 DEG C of kept dries.
There is fibroin and HAp to be segmented the biomaterial of coating simultaneously.
Embodiment 3
1st, fimbrin preparation method
By polypropylene(PP)Material is dipped in 30min in absolute ethyl alcohol, ultrasonically treated 5min, removes surface impurity, with steaming after taking-up
Distilled water is cleaned multiple times to remove residual ethanol, and ultrasound 3 times, each 5min is subsequently placed in drying in 60 DEG C of baking ovens.
PP materials are soaked in sodium hydroxide solution again, are taken out after 2 hours, cleaned with a large amount of distilled water, until pH value
It is neutrality, is placed in 60 DEG C of oven dryings, obtains PP material of the surface with carboxyl.
Silk fibroin powder is dissolved in three distilled water so that its concentration is 4wt%.By the biological implantation materials of above-mentioned PP
Material is immersed in the silk fibroin solution, keeps 4 DEG C, 12h.Take out and dried in 60 DEG C of baking ovens.Then the material is placed in again anhydrous
30min is soaked in ethanol, 60 DEG C of oven dryings after taking-up.
2nd, gelatin/HAp coatings
(1)At 50 DEG C -60 DEG C, gelatin is dissolved in deionized water, mass concentration is 8%, magnetic agitation, treats that gelatin is completely molten
Xie Hou, balance weighs HAp, adds gelatin solution so that the final concentration of 0.3wt% of HAp.
(2)The material of fibroin coating will be completed in 1, wherein needing the portion of material for being segmented coating to be immersed in 2(1)'s
In HAp solution, ultrasonically treated 15 minutes, slowly lift out from solution, 40 DEG C of kept dries.
There is fibroin and HAp to be segmented the biomaterial of coating simultaneously.
Claims (1)
1. a kind of segmentation coating process for body implanting material, it is characterised in that comprise the following steps:
(1)Fimbrin preparation method
A kind of polymer biological implantation material is dipped in 30min, ultrasonically treated 5min in absolute ethyl alcohol, surface impurity is removed, taken
It is cleaned multiple times to remove residual ethanol with distilled water after going out, ultrasound 3 times, each 5min is subsequently placed in drying in 60 DEG C of baking ovens;
Silk fibroin powder is dissolved in three distilled water so that its concentration is 1wt%-4wt%, and above-mentioned polymer biological is planted
Enter material to be immersed in the silk fibroin solution, kept for 4 DEG C, 12h takes out and dried in 60 DEG C of baking ovens, is then again placed in the material
30min is soaked in absolute ethyl alcohol, 60 DEG C of oven dryings after taking-up;
(2)Gelatin/HAp coatings
At 50 DEG C -60 DEG C, gelatin is dissolved in deionized water, mass concentration is 2%-10%, magnetic agitation treats that gelatin is completely molten
Xie Hou, balance weighs HAp, adds gelatin solution so that the final concentration of 0.1-1wt% of HAp;
The material that coating will be segmented is soaked in sodium hydroxide solution, is taken out after 2 hours, is cleaned with a large amount of distilled water, until
PH value is neutrality, is placed in 60 DEG C of oven dryings, obtains polymeric material of the surface with carboxyl;The segmentation material is immersed in
State in HAp solution, ultrasonically treated 15 minutes, slowly lift out from solution, 40 DEG C of kept dries;
It is that can obtain while having fibroin and HAp to be segmented the biomaterial of coating by above-mentioned steps permutation and combination.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611029883.4A CN106729991A (en) | 2016-11-22 | 2016-11-22 | A kind of segmentation coating for body implanting material |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611029883.4A CN106729991A (en) | 2016-11-22 | 2016-11-22 | A kind of segmentation coating for body implanting material |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106729991A true CN106729991A (en) | 2017-05-31 |
Family
ID=58970421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611029883.4A Pending CN106729991A (en) | 2016-11-22 | 2016-11-22 | A kind of segmentation coating for body implanting material |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106729991A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107596442A (en) * | 2017-10-31 | 2018-01-19 | 上海纳米技术及应用国家工程研究中心有限公司 | The preparation method of gradient biological coating on PET material surface and products thereof and application |
CN109621007A (en) * | 2018-12-29 | 2019-04-16 | 四川瑞宝生物科技股份有限公司 | A kind of preparation method of the surface coating of bone grafting material |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1791437A (en) * | 2003-05-16 | 2006-06-21 | 布卢薄膜有限责任公司 | Medical implants comprising biocompatible coatings |
CN101239202A (en) * | 2008-03-12 | 2008-08-13 | 天津大学 | Nano sheet hydroxyapatite and glutin composite material and preparation |
CN105330880A (en) * | 2015-11-17 | 2016-02-17 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of silk fibroin active coating ultra-high molecular weight polyethylene composite artificial ligament material |
-
2016
- 2016-11-22 CN CN201611029883.4A patent/CN106729991A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1791437A (en) * | 2003-05-16 | 2006-06-21 | 布卢薄膜有限责任公司 | Medical implants comprising biocompatible coatings |
CN101239202A (en) * | 2008-03-12 | 2008-08-13 | 天津大学 | Nano sheet hydroxyapatite and glutin composite material and preparation |
CN105330880A (en) * | 2015-11-17 | 2016-02-17 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of silk fibroin active coating ultra-high molecular weight polyethylene composite artificial ligament material |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107596442A (en) * | 2017-10-31 | 2018-01-19 | 上海纳米技术及应用国家工程研究中心有限公司 | The preparation method of gradient biological coating on PET material surface and products thereof and application |
CN107596442B (en) * | 2017-10-31 | 2020-10-27 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of gradient biological coating on PET material surface, product and application thereof |
CN109621007A (en) * | 2018-12-29 | 2019-04-16 | 四川瑞宝生物科技股份有限公司 | A kind of preparation method of the surface coating of bone grafting material |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Feng et al. | Application of 3D printing technology in bone tissue engineering: a review | |
Eliaz et al. | Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications | |
CN103933611B (en) | The preparation method of medical magnesium alloy surface hydroxyapatite/polylactic acid composite coating | |
Thein-Han et al. | Collagen-calcium phosphate cement scaffolds seeded with umbilical cord stem cells for bone tissue engineering | |
Rau et al. | Bioactive materials for bone tissue engineering | |
Latimer et al. | Regenerative medicine technologies to treat dental, oral, and craniofacial defects | |
KR100809574B1 (en) | Bio-affinity implant | |
CN102908661B (en) | Medical titanium with a trace element slow-release function or titanium alloy implant material as well as preparation method and application of same | |
CN106308959B (en) | Biological active glass ceramic fiber and PEEK resin composite materials artificial tooth and preparation method | |
CN102090982B (en) | Artificial tooth root or joint material and microarc oxidation preparation method thereof | |
Manoukian et al. | Spiral layer-by-layer micro-nanostructured scaffolds for bone tissue engineering | |
Sun et al. | Composite scaffolds of mineralized natural extracellular matrix on true bone ceramic induce bone regeneration through Smad1/5/8 and ERK1/2 pathways | |
CN101411894B (en) | Self-assembly modified titanium or titanium alloy material from layer to layer as well as preparation method and use thereof | |
WO2016202100A1 (en) | Polyether ether ketone/nano hydroxyapatite dental implant and manufacturing method thereof | |
CN101829357A (en) | Implant surface biomimetic coating material for promoting sacralization and preparation method thereof | |
CN101757689A (en) | Titanium or titanium alloy having TiO2-HA surface coating and preparation method thereof | |
WO2014165652A1 (en) | Pem layer-by-layer systems for coating substrates to improve bioactivity and biomolecule delivery | |
CN102560598A (en) | Method for preparing medical titanium material with high anti-cancer and antibacterial properties | |
Sheng et al. | Advanced surface modification for 3D-printed titanium alloy implant interface functionalization | |
CN105220451A (en) | There is the preparation method of the polyethylene terephthalate braided material of antibacterial and short mineralization function coating | |
Amann et al. | A graded, porous composite of natural biopolymers and octacalcium phosphate guides osteochondral differentiation of stem cells | |
CN105214140A (en) | The functionalization interface construction method of the titanium alloy of local bone reconstruction and healing in coordinated regulation osteoporosis | |
CN104587526B (en) | A kind of collagen hydroxyapatite Nerve Scaffold and preparation method thereof | |
CN109385658A (en) | Hydroxyapatite nano stick array configuration coating of titanium-based surface multiple element codope and its preparation method and application | |
CN114438782B (en) | Preparation method of polylactic acid/tannic acid/iron/cysteine osteoinduction composite fiber membrane with rapid antibacterial/antioxidant activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |
|
RJ01 | Rejection of invention patent application after publication |