CN106729393A - It is a kind of to treat Chinese medicine preparation of hepatopathy and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine preparation of hepatopathy and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract
The invention provides a kind of Chinese medicine preparation for treating hepatopathy, the raw material matched by following weight is made：20 40 parts of Artemisia japonica, 10 18 parts of smilax, 8 14 parts of radix bupleuri, 5 10 parts of Canton love-pea vine, 10 15 parts of Moschus, 12 16 parts of red madder, 20 30 parts of Cordyceps sinensis, 8 12 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 6 10 parts of Pueraria lobota Bud roots, 49 parts of oldenlandia diffusa, 10 16 parts of selfheal, 7 13 parts of Radix Glycyrrhizae, 38 parts of the Radix Astragali, 10 18 parts of Radix Angelicae Sinensis, 5 10 parts of curcuma zedoary, 15 25 parts of the red sage root, 8 16 parts of the membrane of a chicken's gizzard；The Chinese medicine preparation of present invention treatment hepatopathy is prepared by 17 kinds of Chinese medicinal materials, can be used to treat all types of hepatitis, liver depression blood stasis type liver, courage, spleen, pancreas disease, weight patient especially to cirrhosis, liver ascites has obvious curative effect, and compared with Western medicine, Chinese medicine preparation of the invention is made up of pure Chinese medicine material, and long-term taking has no toxic side effect.
Description
Technical field
It is more particularly to a kind of to treat Chinese medicine preparation of hepatopathy and preparation method thereof the present invention relates to the field of Chinese medicines.
Background technology
With the increasingly quickening of people's rhythm of life, the increase of pressure and is drunk beyond one's capacity at irregular work and rest, liver disease
Disease is more and more universal, the disease such as including various types of hepatitis, cirrhosis, liver ascites, liver fibrosis, fatty liver, alcoholic liver, liver cancer
Disease, is one of principal disease that today's society threatens human health.Because its pathogenic cause of disease is complicated, does not such as treat in time or control
Therapeutic effect is not good, and the state of an illness will deteriorate.At present, medically the treatment of the treatment of above-mentioned hepatopathy, especially hepatitis B etc. is mainly adopted
It is antiviral therapy, because antiviral therapy has its clear and definite indication and contraindication, and by aspects such as economic conditions
The influence of reason, can receive the patient of regular antiviral therapy also than relatively limited, so Most patients can only pass through at present
Anti-inflammatory liver protection prevents the further development of disease.At present, treatment cirrhosis is substantially from traditional Chinese medical science angle without what specific drug
Degree, multiplex soothing liver-qi stagnation is clearing heat and detoxicating, and addiction of dispelling of invigorating blood circulation, softening and resolving hard mass, clearing heat and promoting diuresis medicine takes Western medicine hepatitis virus resisting in addition
And hepatic treatment.Such as using rummy regulation, Entecavir, Ribavirin and interferon antiviral treatment, then
With vitamin K 1 injection, the sweet peptide of paddy skin is reduced, 5% glucose injection adds the liver protections such as vitamin C, potassium chloride, or for oral administration
Silybin Capsules, Anethol Trithione etc. with the inflammation and normalizing gallbladder to cure jaundice in the liver that disappears, but these to treat its effect undesirable, cure slow, control
More rate is low.
Chinese patent CN 103099979B disclose it is a kind of treat hepatitis, cirrhosis, the Chinese medicine of liver ascites, it is existing to solve
There are the reasons such as medication effect difference and invent.Including Anthracites, reed rhizome, lalang grass rhizome, radix bupleuri, Huang Su, obtain Bodhisattva, oriental wormwood.The present invention
Chinese medicine to repairing damage necrosis liver cell, reach healing hepatitis, cirrhosis, the purpose of liver ascites.But this is invented
Slowly effect, cures the basic raising by autoimmunity.The patent application of CN1268362A disclose one kind treat chronic hepatitis,
Liver fibrosis and the medicine of early-phase hepatocirrhosis, its by the Radix Astragali, the red sage root, Radix Angelicae Sinensis, safflower, river Chinese herbaceous peony, rhizoma cyperi, the radix paeoniae rubrathe, radix bupleuri, dried orange peel,
Reticulate millettia various active is into being grouped into, but the cure rate of the medicine is low, at a specified future date least higher.The patent application of CN1539483A
A kind of Chinese medicine for treating chronic liver disease and anti-hepatic fibrosis is disclosed, it is by safflower, gekko, the red sage root, the soft-shelled turtle of proper proportion
The first, Radix Astragali, red ginseng, Radix Angelicae Sinensis, river Chinese herbaceous peony, fructus amomi, bombys batryticatus, pseudo-ginseng, structure are offered sacriffices to the gods or the spirits of the dead, the banksia rose is constituted, and are prepared from through multiple working procedure, Neng Gouyou
Effect ground treatment chronic hepatitis and liver fibrosis.The patent application of CN102357171A discloses a kind of medicine for preventing and treating liver fibrosis
Composition, it includes Radix Angelicae Sinensis, safflower, peach kernel, the root bark of tree peony, the radix paeoniae rubrathe, river Chinese herbaceous peony, the root of three-nerved spicebush, excrementum pteropi, corydalis tuber, rhizoma cyperi, product shell, Radix Glycyrrhizae
Etc. various active compound compositions, the pharmaceutical composition has the effect of prevention and treatment liver fibrosis lesion, can be applied to prepare accordingly
Pharmaceutical preparation.The patent application of CN1016328298 is disclosed and a kind of assembled by bear gall powder, the red sage root, turmeric, the Radix Astragali
Pharmaceutical composition, with obvious liver protection, protect liver, reduces transaminase and suppresses the pharmacological action of liver cell fibrosis.
However, pharmaceutical composition of the prior art also tend to it is not fully up to expectations, for example often show curative effect not enough significantly,
The shortcomings of effect is single, consumption is big.Therefore, developing the new and effective pharmaceutical composition that can be used to treat hepatopathy turns into the present invention
Study tenet where.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of formula simply, steady quality, better efficacy, manufacturing cost
Relatively low Chinese medicine preparation treated for HBV carrier, chronic hepatitis B, cirrhosis, fatty liver and preparation method thereof.
To solve the above problems, the technical solution adopted by the present invention is：
A kind of Chinese medicine preparation for treating hepatopathy, the raw material matched by following weight is made：Artemisia japonica 20-40 parts, smilax 10-
18 parts, radix bupleuri 8-14 parts, Canton love-pea vine 5-10 parts, Moschus 10-15 parts, red madder 12-16 parts, Cordyceps sinensis 20-30 parts, RADIX POLYGONI MULTIFLORI PREPARATA
8-12 parts, 6-10 parts of Pueraria lobota Bud roots, oldenlandia diffusa 4-9 parts, selfheal 10-16 parts, Radix Glycyrrhizae 7-13 parts, Radix Astragali 3-8 parts, Radix Angelicae Sinensis
10-18 parts, curcuma zedoary 5-10 parts, red sage root 15-25 parts, the membrane of a chicken's gizzard 8-16 parts.
Preferably, being made up of the raw material that following weight is matched：Artemisia japonica 25-35 parts, smilax 12-16 parts, radix bupleuri 10-12
Part, Canton love-pea vine 6-8 parts, Moschus 12-14 parts, red madder 13-15 parts, Cordyceps sinensis 24-28 parts, RADIX POLYGONI MULTIFLORI PREPARATA 9-11 parts, Pueraria lobota Bud roots
7-9 parts, oldenlandia diffusa 6-8 parts, selfheal 12-14 parts, Radix Glycyrrhizae 8-10 parts, Radix Astragali 4-6 parts, Radix Angelicae Sinensis 12-16 parts, curcuma zedoary 6-9
Part, red sage root 18-22 parts, the membrane of a chicken's gizzard 10-14 parts.
Further preferably, the raw material for being matched by following weight is made：30 parts of Artemisia japonica, 14 parts of smilax, 11 parts of radix bupleuri, chicken bone
7 parts of grass, 13 parts of Moschus, 14 parts of red madder, 26 parts of Cordyceps sinensis, 10 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 8 parts of Pueraria lobota Bud roots, 7 parts of oldenlandia diffusa, summer
13 parts of withered grass, 9 parts of Radix Glycyrrhizae, 5 parts of the Radix Astragali, 14 parts of Radix Angelicae Sinensis, 8 parts of curcuma zedoary, 20 parts of the red sage root, 12 parts of the membrane of a chicken's gizzard.
Wherein, the formulation of its Chinese medicine preparation is solution, capsule, tablet or dripping pill.
In addition, the preparation method of Chinese medicine preparation of the present invention, comprises the following steps：
(1) Artemisia japonica is weighed by formula, smilax, radix bupleuri, Canton love-pea vine, Moschus, red madder adds 80% alcohol dipping 12 hours,
Refluxing extraction 4 times, 2 hours every time, filtration, filtrate merged, and ethanol is recovered under reduced pressure and the leaching that relative density is 1.2-1.3 is concentrated into
Cream, it is standby；
(2) Cordyceps sinensis is weighed by formula, RADIX POLYGONI MULTIFLORI PREPARATA, Pueraria lobota Bud roots, oldenlandia diffusa, selfheal, Radix Glycyrrhizae, the Radix Astragali, Radix Angelicae Sinensis,
Curcuma zedoary, the red sage root, the membrane of a chicken's gizzard adds 50-90% ethanol after being ground into meal, soaks 3-24 hours, seepage pressure effects, merges and extracts
Liquid, is recovered under reduced pressure ethanol and is condensed into medicinal extract, adds suitable quantity of water to heat 30-60 DEG C of stirring and dissolving, and filtering, filtrate crosses macroreticular resin
Post, with 5-30% ethanol elution impurity, then is desorbed with 50-70% ethanol, collects stripping liquid, reclaims ethanol concentrate drying, is crushed
Dissolved with ethanol afterwards, filtration, filtrate adds silica gel to dry, silicagel column in dry method, eluted with ethyl acetate, collect eluent, reclaimed
Solvent, concentrate drying obtains the extract of blending constituent, standby；
(3) product for taking step (1) and step (2) merges, and heating is mixed, and dry, pulverize into fine powder, is obtained final product；Can also
Fine powder is further made capsule, tablet, granule, soft capsule, oral liquid, soft extract, powder, pill, syrup, stream leaching
Paste.
The pharmacological action of Chinese medicine material of the present invention is as follows：
Artemisia japonica:It is bitter, micro-sweet, cool in nature.Heat-clearing, cool blood, removing toxic substances.Main summer flu, pulmonary tuberculosis hectic fever, spitting of blood, children's sore
Heat, maggot blood, has blood in stool, uterine bleeding, under band, Jaundice Jaundice, erysipelas, venomous snake bite.《Traditional Chinese Medicine in Sichuan will》Carry:" can removing heat from blood, liver
Heat, ebb heat.Control cough, sphincter disturbance.”
Smilax:Antitoxic heart-soothing and sedative, internal heat anticance.Mild in medicine property is with dampness removing is without hindering healthy tendency.Contained smilax acid has enhancing
The effect of immunity, antitumor and calm, hypoglycemic etc..Can be relaxed gastrointestinal smooth muscle, and gastric acid secretion inhibiting prevents liver thin
The effects such as born of the same parents' necrosis, antibacterial.
Canton love-pea vine, sweet, slight bitter is cool.There is removing dampness through diuresis and removing jaundice, it is clearing heat and detoxicating, the effect of dispersing the depressed liver-qi and alleviating pain.It is usually used in damp and hot yellow subcutaneous ulcer,
Side of body rib is not relaxed, and epigastric distending pain, acute mastitis swells and ache.Canton love-pea vine can also save to carry out Baoshang and make dietotherapy in Fascinating face rainy season.
Oldenlandia diffusa:It is clearing heat and detoxicating, carbuncle that disappears dissipating bind, promoting urination and removing dampness.Swollen and ache for acute appendicitis, lung carbuncle, boil, poisonous snake stings
Wound, it can also be used to treat tumour.
Moschus, warm in nature, nontoxic, bitter.Enter the heart, spleen, Liver Channel, there is the function of having one's ideas straightened out, ward off dirty, dredging collateral, scattered silt.In curing mainly
Wind, coma due to blocking of the respiratory system, frightened epilepsy, middle evil unhappiness, trusted subordinate sudden and violent pain, traumatic injury, swollen ulcer drug.
Turbid lipid-loweringing is changed in RADIX POLYGONI MULTIFLORI PREPARATA, filling liver kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles.For blood deficiency chlorosis, dizziness and tinnitus, palpus
Hair is early white, soreness and weakness of waist and knees, extremity numbness, uterine bleeding under band, hyperlipidemia.
Pueraria lobota Bud roots, removing dampness through diuresis and removing jaundice；It is promoting blood circulation and removing obstruction in channels；Removing toxicity for detumescence.Main icteric hepatitis；Arthralgia pain due to rheumatism；Traumatic injury；Carbuncle
It is swollen.
Selfheal, the property of medicine:Pungent, hardship, trembles with fear, Return liver, gallbladder channel.Effect:Clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating.This product bitter cold master
Enter Liver Channel, be apt to purge the green with improving eyesight.With liver-fire flaming is controlled, red eye, swell pain can be medicinal with mulberry leaf, chrysanthemum, cassia seed etc..This clearing liver
Among improving eyesight, slightly and nourishing the liver, with Radix Angelicae Sinensis, the fruit of Chinese wolfberry, can be used for deficiecny of liver-YIN, ophthalmalgia, to night more particularly；Also can be with perfume
Attached, Radix Glycyrrhizae is used, and such as selfheal dissipates.
Curcuma zedoary, pungent, hardship, temperature.Return liver, the spleen channel.Cure mainly " qi and blood stagnation, trusted subordinate's distending pain, abdominal mass, accumulation, place food do not disappear, woman
Female's blood stasis is through closing, traumatic injury is had a pain." root tuber claims " green silk root tuber of aromatic turmeric ", there is promoting qi circulation and removing obstruction in the collateral, broken stasis of blood, the function of analgesic.
Radix bupleuri, bitter in taste, be slightly cold, Return liver, gallbladder channel.Have with inducing diaphoresis, the effect of soothing the liver rising Yang.For cold, fever, tremble with fear
Hot contact, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, the prolapse of uterus, irregular menstruation.
Radix Glycyrrhizae, it is sweet, it is mild-natured.The thoughts of returning home, lung, spleen, stomach.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain is adjusted
With all medicines.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus delay
Solution drug toxicity, strong.
Radix Angelicae Sinensis:Sweet, acrid, warm.Return liver, the heart, the spleen channel.Indication:Replenishing and activating blood, menstruction regulating and pain relieving relaxes bowel.For blood
Empty sallow, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sore
Ulcer.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.
The red sage root:Dispelled addiction with promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity abdomen
Hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
Cordyceps sinensis:There are suppression cell division and antitumaous effect, have nonspecific immune reaction so as to improve body against cancer
Ability, its body mycelia has Jie row for suppressing T thin noons to act on.
The Radix Astragali:Nature and flavor are sweet, temperature.Return lung, the spleen channel.Indication:Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.With
In treatment deficiency of vital energy weak, the deficiency of food just pool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, long
Burst and do not hold back, the deficiency of blood is yellow repeatly, Heat Diabetes；Chronic rephrilis protinuria, diabetes.
The membrane of a chicken's gizzard:Nature and flavor are sweet, put down.Returns spleen, stomach, small intestine, bladder warp.Indication:Stomach strengthening and digestion promoting, arresting seminal emission.For
Dyspepsia, vomiting dysentery, children's sore product, the enuresis, seminal emission.
Red madder, safflower madder, Gentianales madder wort, perennial herb, complete stool is without hair.Root is most, slightly lignifying,
It is red.Stem Chang Zhili climbs up by holding on to shape, grows thickly, the normal branch in top, and the mutual knot of branch is very thin, there is four straight ribs, there is small life on rib
Prickle or sometimes near smooth, long 20-30 centimetres, 1-4 centimetres of internode length.Cool blood, green blood, eliminating the phlegm is stimulated the menstrual flow.
The beneficial effects of the present invention are：
(1) Chinese medicine preparation of present invention treatment hepatopathy is prepared by 17 kinds of Chinese medicinal materials, can be used to treating all types of hepatitis,
Liver depression blood stasis type liver, courage, spleen, pancreas disease, especially the weight patient to cirrhosis, liver ascites have obvious curative effect, and and Western medicine
Compare, Chinese medicine preparation of the invention is made up of pure Chinese medicine material, and long-term taking has no toxic side effect.The Chinese medicine preparation of hepatopathy is treated above
It is to be formed using following theory of traditional Chinese medical science compatibility:Liver is one of the five internal organs, and pathogenesis of liver disease is smouldered with irritability, liver-yang easily high, cloudy blood often loses
It is its feature, liver property happiness bar reaches, main catharsis, with the operation dredged fluent work(, catharsis whole body mechanism of qi, adjust smooth human functional activity of vital energy,
The catharsis of liver additionally aids food digestion absorption, the generation of bile and excretion, the ascending or descending movement of vital Qi beneficial to taste, plays promotion digestion
The function of food, is based on the above feature of hepatopathy, using dispersing stagnated hepatoqi, activate blood circulation and disperse blood clots, it is softening and resolving hard mass, kidney tonifying of relieving oedema or abdominal distension through diuresis or purgation, strong
The medicine of spleen and stomach, develops Chinese medicine preparation of the invention.
(2) using cooperatively by a variety of feature traditional Chinese medicine ingredients of the invention, as an entirety, has reached association
With the effect of synergy, lifting liver regeneration ability and function of detoxification are on the one hand reached, promoted the synthesis of Hepatocyte matter, it is soothing the liver
Qi-regulating, the impaired liver cell of reparation and reduction transaminase effect, another aspect strengthening vital QI to eliminate pathogenic factors, clearing heat and promoting diuresis, clear liver and gallbladder damp-heat,
The wet fire of purging the liver of pathogenic fire courage, for treating acute yellow subcutaneous ulcer hepatitis, chronic yellow subcutaneous ulcer hepatitis, chronic persistant hepatitis, cirrhosis, liver ascites, wine
Essence hepatitis, fatty liver, hepatitis B, transaminase rise high disease, and markedly fast, good effect, cure rate is high, while can also be used to prevent and treat liver
The diseases such as cancer.
Specific embodiment
Technical scheme is further elaborated with reference to embodiment：
Embodiment 1
A kind of Chinese medicine preparation for treating hepatopathy, the raw material matched by following weight is made：20 parts of Artemisia japonica, 10 parts of smilax,
8 parts of radix bupleuri, 5 parts of Canton love-pea vine, 10 parts of Moschus, 12 parts of red madder, 20 parts of Cordyceps sinensis, 8 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 6 parts of Pueraria lobota Bud roots, long-noded pit viper
4 parts of tongue grass, 10 parts of selfheal, 7 parts of Radix Glycyrrhizae, 3 parts of the Radix Astragali, 10 parts of Radix Angelicae Sinensis, 5 parts of curcuma zedoary, 15 parts of the red sage root, 8 parts of the membrane of a chicken's gizzard.
Embodiment 2
A kind of Chinese medicine preparation for treating hepatopathy, the raw material matched by following weight is made：40 parts of Artemisia japonica, 18 parts of smilax,
14 parts of radix bupleuri, 10 parts of Canton love-pea vine, 15 parts of Moschus, 16 parts of red madder, 30 parts of Cordyceps sinensis, 12 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 10 parts of Pueraria lobota Bud roots, in vain
9 parts of HERBA HEDYOTIS DIFFUSAE of flower, 16 parts of selfheal, 13 parts of Radix Glycyrrhizae, 8 parts of the Radix Astragali, 18 parts of Radix Angelicae Sinensis, 10 parts of curcuma zedoary, 25 parts of the red sage root, the membrane of a chicken's gizzard 16
Part.
Embodiment 3
A kind of Chinese medicine preparation for treating hepatopathy, the raw material matched by following weight is made：The raw material matched by following weight
It is made：30 parts of Artemisia japonica, 14 parts of smilax, 11 parts of radix bupleuri, 7 parts of Canton love-pea vine, 13 parts of Moschus, 14 parts of red madder, 26 parts of Cordyceps sinensis,
10 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 8 parts of Pueraria lobota Bud roots, 7 parts of oldenlandia diffusa, 13 parts of selfheal, 9 parts of Radix Glycyrrhizae, 5 parts of the Radix Astragali, 14 parts of Radix Angelicae Sinensis, curcuma zedoary 8
Part, 20 parts of the red sage root, 12 parts of the membrane of a chicken's gizzard.
Embodiment 4
A kind of Chinese medicine preparation for treating hepatopathy, the raw material matched by following weight is made：Artemisia japonica 20-40 parts, smilax 10-
182 parts, 10 parts of radix bupleuri, 6 parts of Canton love-pea vine, 12 parts of Moschus, 14 parts of red madder, 22 parts of Cordyceps sinensis, 10 parts of RADIX POLYGONI MULTIFLORI PREPARATA, Pueraria lobota Bud roots 8
Part, 6 parts of oldenlandia diffusa, 12 parts of selfheal, 9 parts of Radix Glycyrrhizae, 5 parts of the Radix Astragali, 12 parts of Radix Angelicae Sinensis, 7 parts of curcuma zedoary, 18 parts of the red sage root, the membrane of a chicken's gizzard
10 parts.
Embodiment 5
A kind of Chinese medicine preparation for treating hepatopathy, the raw material matched by following weight is made：36 parts of Artemisia japonica, 16 parts of smilax,
12 parts of radix bupleuri, 8 parts of Canton love-pea vine, 13 parts of Moschus, 14 parts of red madder, 28 parts of Cordyceps sinensis, 11 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 8 parts of Pueraria lobota Bud roots are spent in vain
8 parts of HERBA HEDYOTIS DIFFUSAE, 15 parts of selfheal, 11 parts of Radix Glycyrrhizae, 6 parts of the Radix Astragali, 16 parts of Radix Angelicae Sinensis, 8 parts of curcuma zedoary, 23 parts of the red sage root, 14 parts of the membrane of a chicken's gizzard.
Embodiment 6
A kind of Chinese medicine preparation for treating hepatopathy, the raw material matched by following weight is made：Artemisia japonica 20-40 parts, smilax 10
Part, 12 parts of radix bupleuri, 8 parts of Canton love-pea vine, 12 parts of Moschus, 14 parts of red madder, 25 parts of Cordyceps sinensis, 9 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 8 parts of Pueraria lobota Bud roots, in vain
7 parts of HERBA HEDYOTIS DIFFUSAE of flower, 13 parts of selfheal, 11 parts of Radix Glycyrrhizae, 5 parts of the Radix Astragali, 15 parts of Radix Angelicae Sinensis, 6 parts of curcuma zedoary, 19 parts of the red sage root, 13 parts of the membrane of a chicken's gizzard.
The preparation method of the Chinese medicine preparation of embodiment 1-6 comprises the following steps：
(1) Artemisia japonica is weighed by formula, smilax, radix bupleuri, Canton love-pea vine, Moschus, red madder adds 80% alcohol dipping 12 hours,
Refluxing extraction 4 times, 2 hours every time, filtration, filtrate merged, and ethanol is recovered under reduced pressure and the medicinal extract that relative density is 1.25 is concentrated into,
It is standby；
(2) Cordyceps sinensis is weighed by formula, RADIX POLYGONI MULTIFLORI PREPARATA, Pueraria lobota Bud roots, oldenlandia diffusa, selfheal, Radix Glycyrrhizae, the Radix Astragali, Radix Angelicae Sinensis,
Curcuma zedoary, the red sage root, the membrane of a chicken's gizzard adds 70% ethanol after being ground into meal, soaks 16 hours, seepage pressure effects, merges extract solution, decompression
Reclaim ethanol and be condensed into medicinal extract, add suitable quantity of water to heat 50 DEG C of stirring and dissolvings, filter, filtrate crosses macroporous resin column, with 20%
Ethanol elution impurity, then desorbed with 60% ethanol, stripping liquid is collected, ethanol concentrate drying is reclaimed, dissolved with ethanol after crushing, filter
Cross, filtrate adds silica gel to dry, silicagel column in dry method, eluted with ethyl acetate, collect eluent, recycling design, concentrate drying is obtained
The extract of blending constituent, it is standby；
(3) product for taking step (1) and step (2) merges, and heating is mixed, and dry, pulverize into fine powder, is obtained final product；Can also
Fine powder is further made capsule, tablet, granule, soft capsule, oral liquid, soft extract, powder, pill, syrup, stream leaching
Paste.
Clinical test I:
The treatment of hepatitis B is carried out using the Chinese medicine preparation of embodiment 1-6
60 treatment targets of selection, by September, 2000《Virus hepatitis control prece》Standard diagnostics.Wherein male 30
Example, women 30, age 22-60 Sui.
For 60 patients, treated using the Chinese medicine preparation prepared in embodiment 1-6.Respectively take one sooner or later daily
It is secondary, continuous treatment 60 days.
Criterion of therapeutical effect
It is effective:After treatment, seralbumin, globulin, gamma globulin, A/G, Serum ALT are normal；Effectively:Through controlling
After treatment, These parameters have 1 improver, i.e.,:1. albumin rise 5g/L and more than；2. globulin declines at least 3g/L；③γ-
Globulin declines at least 1.5g/L；A/G rises at least 0.；It is invalid:Without above-mentioned changer after treatment.
By treatment, the seralbumin of above-mentioned 60 patients, globulin, gamma globulin, A/G, Serum ALT are recovered
Normally, effective standard is all met.
Observation is tracked over the course for the treatment of for 60 patients, does not find obvious adverse reaction.
Clinical test II:
The treatment of second hepatitis is carried out using the Chinese medicine preparation of embodiment 1-6
Selected 20 patients with chronic hepatitis C meet Xi'an meeting revision in 2000《Chronic hepatitis C is prevented
Control guide》In diagnostic criteria (Chinese Medical Association's infectious disease and parasitic disease credit meeting, hepatopathy credit can virus hepatitis it is anti-
Control scheme [J] China infectious disease magazine, 2001,19 (1):56), wherein man 12, female 8, average age 34.5 years old, the course of disease 1
- 15 years individual month, serum HCV-Ab IgG and HCV-RNA were the positive before treatment, exclude mixed infection first, second, HEV and
The virus infection such as AIDS virus, other antiviral therapies were not received before treatment.
For 20 patients, treated using the Chinese medicine preparation prepared in embodiment 1-6.Respectively take one sooner or later daily
It is secondary, continuous treatment 60 days.
Evaluate criterion of therapeutical effect reference《Hepatitis C guideline of prevention and treatment》(Chinese Medical Association's hepatopathy credit meeting, infectious disease and parasitism
Parasitosis credit can hepatitis C guideline of prevention and treatment [J] China infectious disease magazine, 2004,22:131) specify.All 20 patients exist
Serum HCV-Ab IgG and HCV-RNA switch to feminine gender after treatment, meet the standard of healing.
Observation is tracked over the course for the treatment of for 20 patients, does not find obvious adverse reaction.
A kind of Chinese medicine preparation of hepatopathy and preparation method thereof for the treatment of that the invention is implemented to be provided is carried out above
Detailed introduction, for those of ordinary skill in the art, according to the thought of the invention embodiment, in specific embodiment
And be will change in range of application, in sum, this specification content should not be construed as the limitation to the invention.
Claims (5)
1. a kind of Chinese medicine preparation for treating hepatopathy, it is characterised in that the raw material matched by following weight is made：Artemisia japonica 20-40 parts,
Smilax 10-18 parts, radix bupleuri 8-14 parts, Canton love-pea vine 5-10 parts, Moschus 10-15 parts, red madder 12-16 parts, Cordyceps sinensis 20-30
Part, RADIX POLYGONI MULTIFLORI PREPARATA 8-12 parts, 6-10 parts of Pueraria lobota Bud roots, oldenlandia diffusa 4-9 parts, selfheal 10-16 parts, Radix Glycyrrhizae 7-13 parts, Radix Astragali 3-8
Part, Radix Angelicae Sinensis 10-18 parts, curcuma zedoary 5-10 parts, red sage root 15-25 parts, the membrane of a chicken's gizzard 8-16 parts.
2. Chinese medicine preparation as claimed in claim 1, it is characterised in that the raw material matched by following weight is made：Artemisia japonica 25-35
Part, smilax 12-16 parts, radix bupleuri 10-12 parts, Canton love-pea vine 6-8 parts, Moschus 12-14 parts, red madder 13-15 parts, Cordyceps sinensis
24-28 parts, RADIX POLYGONI MULTIFLORI PREPARATA 9-11 parts, 7-9 parts of Pueraria lobota Bud roots are oldenlandia diffusa 6-8 parts, selfheal 12-14 parts, Radix Glycyrrhizae 8-10 parts, yellow
Stilbene 4-6 parts, Radix Angelicae Sinensis 12-16 parts, curcuma zedoary 6-9 parts, red sage root 18-22 parts, the membrane of a chicken's gizzard 10-14 parts.
3. Chinese medicine preparation as claimed in claim 2, it is characterised in that the raw material matched by following weight is made：30 parts of Artemisia japonica,
14 parts of smilax, 11 parts of radix bupleuri, 7 parts of Canton love-pea vine, 13 parts of Moschus, 14 parts of red madder, 26 parts of Cordyceps sinensis, 10 parts of RADIX POLYGONI MULTIFLORI PREPARATA, Pueraria lobota
8 parts of Bud roots, 7 parts of oldenlandia diffusa, 13 parts of selfheal, 9 parts of Radix Glycyrrhizae, 5 parts of the Radix Astragali, 14 parts of Radix Angelicae Sinensis, 8 parts of curcuma zedoary, 20 parts of the red sage root, chicken
Interior golden 12 parts.
4. the Chinese medicine preparation as described in claim any one of 1-3, it is characterised in that its formulation is solution, capsule, tablet or drop
Ball.
5. the preparation method of the Chinese medicine preparation according to claim any one of 1-3, it is characterised in that comprise the following steps：
(1) Artemisia japonica is weighed by formula, smilax, radix bupleuri, Canton love-pea vine, Moschus, red madder adds 80% alcohol dipping 12 hours, is flowed back
Extract 4 times, 2 hours every time, filtration, filtrate merged, ethanol be recovered under reduced pressure and the medicinal extract that relative density is 1.2-1.3 is concentrated into,
It is standby；
(2) Cordyceps sinensis, RADIX POLYGONI MULTIFLORI PREPARATA, Pueraria lobota Bud roots, oldenlandia diffusa, selfheal, Radix Glycyrrhizae, the Radix Astragali, Radix Angelicae Sinensis, cowherb are weighed by formula
Art, the red sage root, the membrane of a chicken's gizzard adds 50-90% ethanol after being ground into meal, soaks 3-24 hours, seepage pressure effects, merges extract solution,
Ethanol is recovered under reduced pressure and medicinal extract is condensed into, adds suitable quantity of water to heat 30-60 DEG C of stirring and dissolving, filtering, filtrate crosses macroporous resin column,
With 5-30% ethanol elution impurity, then desorbed with 50-70% ethanol, collect stripping liquid, reclaim ethanol concentrate drying, used after crushing
Ethanol dissolves, and filtration, filtrate adds silica gel to dry, silicagel column in dry method, is eluted with ethyl acetate, collection eluent, recycling design,
Concentrate drying obtains the extract of blending constituent, standby；
(3) product for taking step (1) and step (2) merges, and heating is mixed, and dry, pulverize into fine powder, is obtained final product；Can also carefully
Powder is further made capsule, tablet, granule, soft capsule, oral liquid, soft extract, powder, pill, syrup, liquid extract
Agent.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113779A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Anti- hepatitis B preparation |
| CN1887321A (en) * | 2005-07-02 | 2007-01-03 | 刘河 | Chinese medicine decoction for inhibiting hepatitis B virus |
| CN101130008A (en) * | 2007-08-21 | 2008-02-27 | 王兴明 | Medicine, capsule for treating hepatitis B, and method of preparing the same |
-
2016
- 2016-12-20 CN CN201611182656.5A patent/CN106729393A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113779A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Anti- hepatitis B preparation |
| CN1887321A (en) * | 2005-07-02 | 2007-01-03 | 刘河 | Chinese medicine decoction for inhibiting hepatitis B virus |
| CN101130008A (en) * | 2007-08-21 | 2008-02-27 | 王兴明 | Medicine, capsule for treating hepatitis B, and method of preparing the same |
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