CN106728487A - It is a kind of to treat Chinese medicine composition of waist dish outstanding and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of waist dish outstanding and preparation method thereof Download PDFInfo
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- CN106728487A CN106728487A CN201710080486.8A CN201710080486A CN106728487A CN 106728487 A CN106728487 A CN 106728487A CN 201710080486 A CN201710080486 A CN 201710080486A CN 106728487 A CN106728487 A CN 106728487A
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Abstract
Chinese medicine composition of waist dish outstanding and preparation method thereof is treated the present invention relates to a kind of.The Chinese medicine is prepared from by Chinese medicine materials such as Erionota thorax (Linne), ciliate desert-grass, Caulis et Folium piperis, pigeonpea, kwan-yin amaranth, Japanese Cayratia Herb, champion bauhinia stem, indian abution root, gymnema sylvestre, Li wood, mountain tortoise, Mallotus philippinensis, greyhair cipadessa root or leaf, paint Husband's older sister.Present invention also offers the preparation method of this Chinese medicine composition.The Chinese medicine composition that the present invention is provided is mainly used in treating waist dish outstanding.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating waist dish outstanding and its preparation side
Method.
Background technology
The protrasion of the lumbar intervertebral disci is early recognized from for the traditional Chinese medical science, but does not have corresponding disease name of disease in traditional Chinese medical science field.Knot
The sick cause of disease, the interpretation of the cause, onset and process of an illness and the clinical manifestation is closed, this disease belongs to traditional Chinese medicine " pain in the back ", " numbness pain ", " deficiency of the kidney ", the model of " pain in waist and lower extremities "
Farmland.《Plain Questions shouting pain opinion》Cloud：" sufficient TAI YANG pulse makes us pain in the back, draws heavy sensation in the nape,spinal column,buttocks and back ".《Plain Questions bi Zheng opinion》Say：
" wet three gas of chill is miscellaneous extremely, combined into numbness." say again：" pain person more than cold air, there is cold therefore pain.Say again：" numbness be bone then
Weight, be arteries and veins then blood clotting without stream, be muscle then bend do not stretch, be then meciless meat, be Pi Zehan.”《The Yellow Emperor's Canon of Internal Medicine》In
There is the related record of " hard rachiagia ", " lumbar vertebra pain ", " painful loins and legs ".From《The Yellow Emperor's Canon of Internal Medicine》Classical discuss to ancient Chinese medicine doctor pair
The theoretic discussion of the diseases such as pain in the back, rheumatism, to the discussion that traditional Chinese medical science lumbago and scelalgia is complete because the interpretation of the cause, onset and process of an illness has, it is believed that its cause of disease is wound
Strain and damp and hot perverse trend of catching cold, cause battalion to defend imbalance, qi and blood channels and collaterals and be damaged, or due to kidney deficiency and liver, exopathogen take advantage of a weak point in opponent's defence and
Enter, cause qi and blood stagnation and fall ill.《The inverse tune of Plain Questions is discussed》Say：" ying-qi then meciless, the weakness of defensive QI resulting in flaccidity of void, battalion defends all void,
It is then meciless and without." kidney deficiency and liver, qi-blood deficiency, perverse trend is lied prostrate deeply, is controlled when wind clearing damp is searched, with stopping numbness pain；Liver and kidney benefiting, tonifying Qi
Blood, strengthening vital QI to eliminate pathogenic factors.Description in these documents is essentially identical with the clinical manifestation of the protrasion of the lumbar intervertebral disci of modern medicine.《
Interior warp》Cloud：" wet three gas of chill is miscellaneous extremely, combined into numbness." through cloud again：" pain person, more than cold air, there is cold therefore pain, and it is not bitterly meciless
Person, disease enters depth long, and Rong Wei trips are puckery, is dredged during channels and collaterals, therefore mends pain, and skin is not flourish, therefore meciless.”《Plain Questions bi Zheng opinion》In
There is the related record of " hard rachiagia ", " lumbar vertebra pain ", " painful loins and legs ".
The etiology and pathogenesis of the protrasion of the lumbar intervertebral disci
1 liver-kidney deficiency
The traditional Chinese medical science thinks that this disease is that ferritic prolonged illness is lost and controlled, and insufficiency of vital energy and blood, or native endowment is not enough, or caused by the day after tomorrow weakness of the spleen and the stomach grade
Liver-kidney deficiency, insufficiency of vital energy and blood then muscles and bones growth it is not flourish, ultimately result in the disease occur.Kidney is located at waist, backbone both sides, left and right
Each one, therefore《Plain Questions arteries and veins wants precise and tiny opinion》Say：It is Source of life because kidney hides congenital essence, makes the essence that kidney is " congenital ",
Kidney storing essence, raw marrow, main bone.Therefore i.e. kidney essense is enriched, and marrow biochemistry is active, then bone obtains the nourishing of marrow and firm strong,
If kidney essence deficiency, marrow is hollow.Therefore, lumbar vertebrae or even whole skeletal support, exercise intensity and durability are maintained, is mainly taken
Certainly in kidney, if kidney essence deficiency, marrow is hollow, has knee leg weak foot with symptoms such as pain！Due between waist and kidney
Substantial connection, if kidney diaseases, often the first reaction since waist, while pain in the back symptom is more obvious.It can be seen that
Kidney has close ties in terms of the physiology of backbone and in terms of pathology.Chao Yuanfang (550-630 A.D.)《The General Treatise on the Cause and Symptoms of Diseases》Discussion to this disease
Compare comprehensively, say that " all lumbago diseases have five：One says few the moon, few the moon kidney.July yang-energy is hindered, and is with Low Back Pain：Two say wandering arthritis, wind
It is cold to write waist, it is with pain；Three say kidney deficiency, use as a servant with being impairment of the kidney, and are with pain；Four say temporary waist, and trauma due to a fall waist is with pain：Five to say bedroom sleeping wet
Ground, is with pain.”《The inverse tune of Plain Questions is discussed》Say：" ying-qi void then meciless, weakness of defensive QI resulting in flaccidity, battalion defend all void, then it is meciless without
With." the above discusses and summarize the etiology and pathogenesis of pain in the back.《All pathogeny marquis opinions, Low Back Pain marquis》Think, except wound waist
Cause " pain in the back " outward, other aspects have substantial connection with kidney qi is deficient.The famous physician's Wang Kentang of the Ming Dynasty also has original to this disease
Understanding, he think this disease " have wind, have it is wet, have it is cold, have heat, have the sudden strain of a muscle, have hemostasis, have stagnant gas, have phlegm product, all mark, kidney deficiency
Its.It is that, with kidney asthenia as the principal aspect, with being invaded by exogenous pathogen,invasion of exogenous pathogen, falling winks frustrates are mark to study carefully its origin cause of formation.”.Simple serious falling flutters wound, then
Damage muscles and bones, the passages through which vital energy circulates qi and blood stasis of blood stay with waist and send out.Western medicine is appreciated and understood by the pathology of the protrasion of the lumbar intervertebral disci
Pathogenesis in terms of curing to pain in back and loin syndrome is consistent.《Plain Questions is to will very discuss greatly》Say：" numbness person, spinal column head term
Bitterly, disease dizzy when ... is originally in kidney." explicitly point out the lesion of backbone, the fundamental cause of water disease being in the kidney.Kidney essense is full, liver blood is full, then muscles and bones
Powerful, then muscles and bones mistake is supported for kidney essence deficiency, liver blood loss, and activity is unfavorable.When people is to 30-50, every physiological function starts to go down,
Liver kidney essense blood increasingly loses, and is easily caused human body tendon and vessel and loses foster, the generation protrasion of the lumbar intervertebral disci.Therefore protrusion of lumber intervertebral disc is caused
The basic reason of disease be caused by liver and kidney deficiency, muscles and bones lose support.
2 being invaded by exogenous pathogen,invasion of exogenous pathogen：
Exopathogen：System is attacked by wind, cold, wet is evil, and qi and blood stagnation, channels and collaterals are obstructed, ache so as to waist muscle, muscles and bones occur,
It is numb, weigh, the symptom such as activity is unfavorable.The invasion and attack of exopathogen, mainly because of positive unsaturated vapor, internal cause is the base that exopathogen invasion and attack occur
Plinth, numbness is hindered in channels and collaterals, causes qi and blood stagnation, waist muscle obstruction of meridians and collaterals of being not only involved, and more aggravates degenerative lumbar, on the other hand
The stability of lumbar vertebrae is further influenceed, causes this disease.
3 chronic strains
Often bow, the duration of standing is long, spinal curvature, cause local blood supply insufficiency, the resistance of tendon and vessel numbness, qi and blood stagnation, circulation
Bad, tendon, bone, muscle nutrition lack, and are susceptible to the protrasion of the lumbar intervertebral disci.
4 falling winks frustrates
Traumatic injury, waist or improper or heavy duty, the muscle of damage, channels and collaterals hemostasis rest on the small of the back and cause pain.《Jing Yue
Pandect pain in the back》Cloud：" fall to flutter and hinder and pain in the back person, this wound is in muscles and bones, and blood vessels stagnate and also fall servant ".Damage as the disease of this disease
Cause, the consequence for causing is relevant with the weight and the physical condition of patient damaged.Wound causes the generation of the protrasion of the lumbar intervertebral disci to answer
There are two preconditions：First it is this void of kidney qi, it is outer mainly under the premise of lumbar vertebrae pathologic regression to be acted on through external force, cause
Lumbar vertebrae is integrally unbalance, causes section tissue such as muscle, joint injury and then develops into protrusion of lumber intervertebral disc or abjection.Its
Secondary is waist the past trauma history, and prolonged mistake is controlled, and loses foster in moistening, and causes degenerative lumbar to be aggravated, or is formed because multiple external force is damaged
The protrasion of the lumbar intervertebral disci.Now qi and blood stagnation and kidney deficiency and deposit, hemostasis is mark, and kidney asthenia as the principal aspect.
5 is in congenital malformation
Influenceed by genetic, lumbar vertebrae forms congenital malformation, maleformation easily occurs lesion.The defect of interverbebral disc itself：Vertebra
Disk long-term lacking blood circulation after adult, the repair ability of itself is poor.The posterolateral fibrous ring of interverbebral disc is weak, and
Posterior longitudinal ligament width in the 5th lumbar vertebrae, the 1st rumpbone plane is substantially reduced, and the booster action to fibrous ring substantially weakens.Waist
Sacrum section birth defect：Lumbosacral segment deformity can increase the incidence of disease, and these exceptions cause intervertenral space width, and often result in
Joint protrudes, and joint is subject to more rotation strains, and the pressure for being subject to fibrous ring differs, and accelerates regression.
With the development of science and technology, modern medicine is also more and more for the research of drug therapy this disease, in, west
The pharmaceutical research of the medicine treatment protrasion of the lumbar intervertebral disci is also more and more extensive.There is scholar's research to think that oral medicinal herb can be effective
Alleviate nerve root oedema, promote the disease of inflammatory mediator to absorb, release soft tissue adhesion, promote injured nerve reparation, improve nucleus pulposus
The effect such as pH values and immune, regulation local microcirculation.Wide main of the current clinical practice of western medicine have dehydrating agent,
Non-steroidal anti-inflammatory class and neurotrophy class medicine, it primarily serves alleviation nerve root oedema, analgesia, the effect of trophic nerve, but
It is that its long-range curative effect is poor, and with certain side effect.Continued to develop with pharmacological, between treatment by Chinese herbs lumbar vertebrae
The scientific basis of disc protrusion, its mechanism of action is more and clearer and more definite, therefore, should be combined from multidisciplinary, multi-level, multi-angle and faced
Bed observation is set about, and the therapeutic scheme of safety and reliability is worked out, preferably to serve patient.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating waist dish outstanding；
It is a further object of the present invention to provide a kind of preparation method of the Chinese medicine composition for treating waist dish outstanding.
The purpose of the present invention is realized by following technical scheme：
The Chinese medicine composition for the treatment of waist dish outstanding of the present invention, is prepared from by the Chinese medicine material of following weight portion
's：
Erionota thorax (Linne) 5-15 parts, ciliate desert-grass 10-30 parts, Caulis et Folium piperis 25-45 parts, pigeonpea 10-30 parts, 25-45 parts of kwan-yin amaranth, black liana
Certain kind of berries 10-30 parts, champion bauhinia stem 10-30 parts, indian abution root 5-15 parts, 25-45 parts of gymnema sylvestre 10-30 Fen, Li wood, 5-15 parts of mountain tortoise,
Mallotus philippinensis 10-30 parts, greyhair cipadessa root or leaf 25-45 parts, 10-30 parts of Husband's older sister of paint.
Preferably, it is to be prepared from by the Chinese medicine material of following weight portion：
Erionota thorax (Linne) 8-12 parts, ciliate desert-grass 15-25 parts, Caulis et Folium piperis 30-40 parts, pigeonpea 15-25 parts, 30-40 parts of kwan-yin amaranth, black liana
Certain kind of berries 15-25 parts, champion bauhinia stem 15-25 parts, indian abution root 8-12 parts, 30-40 parts of gymnema sylvestre 15-25 Fen, Li wood, 8-12 parts of mountain tortoise,
Mallotus philippinensis 15-25 parts, greyhair cipadessa root or leaf 30-40 parts, 15-25 parts of Husband's older sister of paint.
The following is the crude drug source of Chinese medicine preparation of the present invention：
Erionota thorax (Linne), is the larva or adult of Hesperiidae animal Erionota thorax (Linne).【Nature and flavor】It is bitter；It is cold.【Return through】Liver；Gallbladder channel.【Work(
Can cure mainly】It is clearing heat and detoxicating；Swelling and pain relieving.
Ciliate desert-grass, fern Pteridaceae Pteris plant ciliate desert-grass Pteris vittata L., with herb or root shape
Stem is used as medicine.【Nature and flavor】It is light, put down.【Indication】Expelling wind and activating blood flow, detoxify desinsection.For preventing and treating influenza, dysentery, rheumatism
Pain, traumatic injury；Centipde-bite, scabies are controlled in external application.
Caulis et Folium piperis, are Piperaceae pepper platymiscium CAULIS PIPER WALLICHII Piper wallichii（Miq.） Hand.-Mazz. var
hupehense （DC.）Hand.-mazz., it is used as medicine with stem, leaf or complete stool.【Nature and flavor】It is pungent, temperature.【Indication】Wind-damp dispelling, by force
Waist and knee, analgesic, cough-relieving.For arthralgia pain due to rheumatism, bruise, waist-leg weakness, dysmenorrhoea, anemofrigid cold, cough and asthma.
Pigeonpea, pulse family pigeonpea platymiscium pigeonpea Cajanus cajan（L.）Millsp. [C. flavus DC.], with root
It is used as medicine.Autumn and winter are adopted, and clean segment is dried.【Nature and flavor】It is pungent, puckery, put down.【Indication】It is inducing diuresis and reducing edema, blood stasis removing analgesic.For jaundice
Type hepatitis, rheumatic arthritis, traumatic injury, blood stasis and swelling pain is had blood in stool, bleeding from five sense organs or subcutaneous tissue.
Kwan-yin amaranth, is the herb of feverfew kwan-yin amaranth.【Nature and flavor】Micro-sweet is pungent, puts down.【Indication】Promoting blood circulation and hemostasis, solution
Poison detumescence.Dysmenorrhoea is controlled, metrorrhagia, hemoptysis, traumatic bleeding, ulcer does not close up long.
Japanese Cayratia Herb, is vitaceae Japanese Cayratia Herb Cayratia japonica（Thunb.）Gagnep., herb.
【Nature and flavor】Bitter, acid, trembles with fear.【Indication】Removing toxicity for detumescence, promoting blood circulation to remove blood stasis, diuresis, hemostasis.For abscess of throat, mesh screen, spit blood,
Blood urine, dysentery；Carbuncle swells, erysipelas, parotitis, traumatic injury, venomous snake bite are controlled in external application.
Champion bauhinia stem, is the stem of legume Bauhinia champloni.【Nature and flavor】Toil, puts down, nontoxic.【Indication】Wind-dispelling, stasis eliminatings,
Analgesic.Control treating rheumatic ostealgia, bruise synthetism.
Indian abution root, is the root of malvaceae plant honewort.【Nature and flavor】It is sweet light, it is cool.【Indication】Heat-clearing, dampness removing is opened
Key, promoting blood circulation.
Gymnema sylvestre, Asclepiadaceae Gymnema plant gymnema sylvestre Gymnema sylvestre（Retz.） Schult.[G.
alterniflorum （Lour.）Merr.], it is used as medicine with root and complete stool.【Nature and flavor】Hardship, puts down.【Indication】It is clearing heat and detoxicating, dispel
Wind is relieved pain.For rheumatic arthritis, carbuncle furuncle poison, venomous snake bite.
Li wood, Du Juan flowers section Li wood Lyonia ovalifolia（Wall.）Drude var.elliptica （Sieb.
et Zucc.）Hand.-Mazz., it is used as medicine with root, fruit, leaf.【Nature and flavor】Sweet, acid, puts down.【Indication】Invigorating the spleen to arrest diarrhea, promoting blood circulation,
Strong muscle.
Mountain tortoise, is menispermaceous plants kwangsi stephania root, osmanthus south Stephania epigaea, great Ye Stephania epigaeas, bleedingheart stephania herb, Mashan
The root tuber of Stephania epigaea, little Hua Stephania epigaeas and greenyellow stephania root etc..【Nature and flavor】It is bitter；It is cold.【Return through】Stomach；Liver Channel.【Indication】Dissipate
The stasis of blood is relieved pain；It is clearing heat and detoxicating.
Mallotus philippinensis, Euphorbiaceae Mallotus plant Mallotus philippinensis Mallotus philippinensis（Lam. ）Muell.-
Arg., it is used as medicine with root.【Nature and flavor】Slight bitter, micro-puckery, it is cool.【Indication】Root：Clearing heat and promoting diuresis.
Greyhair cipadessa root or leaf, is the root or leaf of Meliaceae plant gray wool Cipadessa baecifera Miq.【Nature and flavor】It is arduous, tepor.【Indication】Wind-dispelling
It is wet, promoting qi circulation and relieving pain.
Paint Husband's older sister, is the branches and leaves of euphorbia plant comospore Glochidion puberum.【Nature and flavor】Bitter；It is puckery；It is mild-natured.【Indication】Drive
Wind dampness removing, dissipates the stasis of blood, hemostasis, detumescence.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is
Extracted using the ethanol of water extraction or 40-80% concentration expressed in percentage by volumes and be prepared from.Specific preparation method is as follows：
Scheme one：Take whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water equivalent to 6-12 times of medicinal material gross weight,
Each extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is 1.15-1.20 when filtrate is concentrated into 70-80 DEG C
Clear cream, obtain final product active component.
Scheme two：Whole medicinal materials are taken, is extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol consumption is medicinal material total amount
4-10 times, extraction time be 1-4 hour, merge extract solution, filter, relative density is when filtrate is concentrated into 70-80 DEG C
The clear cream of 1.15-1.20, obtains final product active component.
Scheme three：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, 6- of each amount of water equivalent to medicinal material gross weight
12 times, each extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is when filtrate is concentrated into 70-80 DEG C
The clear cream of 1.15-1.20, adds ethanol, makes alcohol content for 40-70%, stands 12-24 hours, and filtration, filtrate is concentrated into 70-80
DEG C when relative density for 1.10-1.25 medicinal extract, obtain final product active component.
The Chinese medicine composition for the treatment of waist dish outstanding of the present invention, can also match somebody with somebody with pharmaceutically acceptable carrier
Close, be made various oral formulations, such as pill, tablet, capsule, oral liquid, syrup, mixture.
Pharmaceutically acceptable carrier of the invention includes but is not limited to following：
Oral formulations：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring：Sucrose, monose, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1：Tablet
Scheme one is taken one of to the gained active component of scheme three, adds tablet often to use auxiliary material, routinely production method is prepared into this
Invention tablet.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 2：Capsule
Scheme one is taken one of to the gained active component of scheme three, adds capsule often to use auxiliary material, routinely production method is prepared into
Capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 3：Syrup
Scheme one is taken one of to the gained active component of scheme three, adds syrup often to use auxiliary material, routinely production method is prepared into
Syrup of the present invention.
Above-mentioned syrup often includes one of flavouring, preservative, cosolvent or whole with auxiliary material.
Method 4：Mixture
Scheme one is taken one of to the gained active component of scheme three, adds mixture often to use auxiliary material, routinely production method is prepared into this
Invention mixture.
Above-mentioned mixture often includes one of flavouring, preservative or whole with auxiliary material.
Method 5：Oral liquid
Scheme one is taken one of to the gained active component of scheme three, dissolving after-purification, concentration add oral liquid often to use auxiliary material, by normal
Rule production method is prepared into oral liquid of the present invention.
The applicant is reading document at all times extensively, with Traditional Chinese medical theory, with reference to modern diagnosis and treatment experience, finds one kind
Treat the Chinese medicine composition of disease of proplapse of lumbar intervertebral disc.Caulis et Folium piperis, champion bauhinia stem, greyhair cipadessa root or leaf wind-damp dispelling in side, strong waist and knee, promoting the circulation of qi stop
Bitterly；The strong muscle of Li woodwork blood, monarch drug in a prescription in the side of being；Ciliate desert-grass expelling wind and activating blood flow；Pigeonpea damp-clearing pain-relieving；Kwan-yin amaranth promoting blood circulation and stopping pain；Japanese Cayratia Herb,
Indian abution root, gymnema sylvestre promoting blood circulation heat-clearing, wind-expelling pain-stopping；Paint Husband's older sister's alleviating rheumatism and be minister；Erionota thorax (Linne), mountain tortoise be clearing heat and detoxicating,
Swelling and pain relieving；Mallotus philippinensis clearing heat and promoting diuresis, and it is assistant.Full side is taken a broad view of, with expelling wind and activating blood flow, the strong waist of strong muscle, the effect of damp-clearing pain-relieving.
Can be effectively used for the treatment of waist dish outstanding.
A kind of Chinese medicine composition for treating waist dish outstanding that the present invention is provided has advantages below：
1st, the composite preparation that the present invention is provided safely and effectively, with expelling wind and activating blood flow, the strong waist of strong muscle, the effect of damp-clearing pain-relieving.Can
Effective for the treatment of waist dish outstanding.
2nd, clinical tests prove that, after being treated to waist dish outstanding patient with the present invention, effective percentage shows this up to 97.75%
Invention can effectively treat waist dish outstanding.
3rd, the Chinese medicinal composition preparation that the present invention is provided, rationally, process is simple is in good taste, low cost for scientific formulation.
Specific embodiment
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating
The present invention is rather than limitation of the present invention.Essence of the invention belongs to the present invention to the simple modifications that the present invention is carried out
Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
The granule of embodiment 1
Weigh Erionota thorax (Linne) 5g, ciliate desert-grass 10g, Caulis et Folium piperis 25g, pigeonpea 10g, kwan-yin amaranth 25g, Japanese Cayratia Herb 10g, champion bauhinia stem 10g,
Indian abution root 5g, gymnema sylvestre 10g, Li wood 25g, mountain tortoise 5g, Mallotus philippinensis 10g, greyhair cipadessa root or leaf 25g, paint Husband's older sister 10g.Extracting in water 3
Secondary, three amount of water are respectively 12 times of medicinal material gross weight, 8 times, 6 times, three extraction times be respectively 3 hours, 2 hours, it is 1 small
When, merge extract solution, filter, relative density is 1.25 clear cream when filtrate is concentrated into 70 DEG C, adds starch, dextrin, pelletizes, does
Dry, whole grain is obtained final product.
The tablet of embodiment 2
Weigh Erionota thorax (Linne) 15g, ciliate desert-grass 30g, Caulis et Folium piperis 45g, pigeonpea 30g, kwan-yin amaranth 45g, Japanese Cayratia Herb 30g, champion bauhinia stem
30g, indian abution root 15g, gymnema sylvestre 30g, Li wood 45g, mountain tortoise 15g, Mallotus philippinensis 30g, greyhair cipadessa root or leaf 45g, paint Husband's older sister 30g.Use second
Alcohol reflux is extracted 2 times, and each concentration of alcohol is respectively 80%, 60%, and each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times,
Extraction time is respectively 4 hours, 3 hours, merges extract solution, filters, and relative density is 1.10 leaching when filtrate is concentrated into 80 DEG C
Cream, adds supplementary product starch, ethanol, talcum powder, and tablet is obtained.
The tablet of embodiment 3
Weigh Erionota thorax (Linne) 8g, ciliate desert-grass 15g, Caulis et Folium piperis 30g, pigeonpea 15g, kwan-yin amaranth 30g, Japanese Cayratia Herb 15g, champion bauhinia stem 15g,
Indian abution root 8g, gymnema sylvestre 15g, Li wood 30g, mountain tortoise 8g, Mallotus philippinensis 15g, greyhair cipadessa root or leaf 30g, paint Husband's older sister 15g.Extracting in water 3
Secondary, three amount of water are respectively equivalent to 12 times of medicinal material gross weight, 8 times, 6 times, each extraction time distinguish 3 hours, 2 hours, 1
Hour, merge extract solution, filtration, relative density is 1.20 clear cream when filtrate is concentrated into 70 DEG C, adds ethanol, makes the alcohol content be
40%, 24 hours are stood, filtration, filtrate is concentrated into the medicinal extract that relative density when filtrate is concentrated into 70 DEG C is 1.10, adds auxiliary material to form sediment
Powder, ethanol, talcum powder, are obtained tablet.
The capsule of embodiment 4
Weigh Erionota thorax (Linne) 12g, ciliate desert-grass 25g, Caulis et Folium piperis 40g, pigeonpea 25g, kwan-yin amaranth 40g, Japanese Cayratia Herb 25g, champion bauhinia stem
25g, indian abution root 12g, gymnema sylvestre 25g, Li wood 40g, mountain tortoise 12g, Mallotus philippinensis 25g, greyhair cipadessa root or leaf 40g, paint Husband's older sister 25g.With 40%
Alcohol reflux is extracted 3 times, and each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, 4 times, extraction time distinguish 3 hours, 2
Hour, 1 hour, merge extract solution, filter, relative density is 1.25 medicinal extract when filtrate concentrates 60 DEG C, is added in medicinal extract auxiliary
Material starch, ethanol, dextrin, magnesium stearate, are made capsule according to a conventional method.
The granule of embodiment 5
Weigh Erionota thorax (Linne) 10g, ciliate desert-grass 20g, Caulis et Folium piperis 35g, pigeonpea 20g, kwan-yin amaranth 35g, Japanese Cayratia Herb 20g, champion bauhinia stem
20g, indian abution root 10g, gymnema sylvestre 20g, Li wood 35g, mountain tortoise 10g, Mallotus philippinensis 20g, greyhair cipadessa root or leaf 35g, paint Husband's older sister 20g.Add water
Extract 2 times, each amount of water is respectively equivalent to 12 times of medicinal material gross weight, 10 times, each extraction time be respectively 3 hours, it is 2 small
When, merging extract solution, filtration, filtrate is concentrated into the clear cream that relative density at 80 DEG C is 1.05, adds ethanol, makes the alcohol content be
70%, 12 hours are stood, filtration, relative density is 1.25 medicinal extract when filtrate is concentrated into 70 DEG C, adds starch, dextrin, pelletize,
Dry, whole grain is obtained final product.
The syrup of embodiment 6
Weigh Erionota thorax (Linne) 6g, ciliate desert-grass 12g, Caulis et Folium piperis 28g, pigeonpea 12g, kwan-yin amaranth 28g, Japanese Cayratia Herb 12g, champion bauhinia stem 12g,
Indian abution root 6g, gymnema sylvestre 12g, Li wood 28g, mountain tortoise 6g, Mallotus philippinensis 12g, greyhair cipadessa root or leaf 28g, paint Husband's older sister 12g.Extracting in water 2
Secondary, amount of water is respectively 10 times of medicinal material gross weight, 8 times twice, twice extraction time be respectively 2 hours, 1 hour, merging is carried
Liquid is taken, is filtered, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C.Syrup auxiliary material sucrose, mountain are added in medicinal extract
Pears acid, water stir, and syrup is obtained.
The oral liquid of embodiment 7
Weigh Erionota thorax (Linne) 9g, ciliate desert-grass 18g, Caulis et Folium piperis 32g, pigeonpea 18g, kwan-yin amaranth 32g, Japanese Cayratia Herb 18g, champion bauhinia stem 18g,
Indian abution root 9g, gymnema sylvestre 18g, Li wood 32g, mountain tortoise 9g, Mallotus philippinensis 18g, greyhair cipadessa root or leaf 32g, paint Husband's older sister 18g.Extracting in water 2
Secondary, amount of water is respectively 10 times of medicinal material gross weight, 8 times twice, twice extraction time be respectively 2 hours, 1 hour, merging is carried
Take liquid, filter, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C, added in medicinal extract auxiliary material mannitol, sorbic acid,
Water stirs, packing, and oral liquid is obtained.
The mixture of embodiment 8
Weigh Erionota thorax (Linne) 11g, ciliate desert-grass 23g, Caulis et Folium piperis 38g, pigeonpea 23g, kwan-yin amaranth 38g, Japanese Cayratia Herb 23g, champion bauhinia stem
23g, indian abution root 11g, gymnema sylvestre 23g, Li wood 38g, mountain tortoise 11g, Mallotus philippinensis 23g, greyhair cipadessa root or leaf 38g, paint Husband's older sister 23g.Add water
Extract 3 times, three amount of water are respectively equivalent to 12 times of medicinal material gross weight, 8 times, 6 times, each extraction time distinguish 3 hours, 2
Hour, 1 hour, merge extract solution, filtration, filtrate concentration ad pond om is 3 times of medicinal material gross weight, and filling, addition mixture is auxiliary
Material sucrose, ethyl ester, water, sorbic acid stir, and mixture is obtained.
The pulvis of embodiment 9
Weigh Erionota thorax (Linne) 14g, ciliate desert-grass 28g, Caulis et Folium piperis 42g, pigeonpea 28g, kwan-yin amaranth 42g, Japanese Cayratia Herb 28g, champion bauhinia stem
28g, indian abution root 13g, gymnema sylvestre 28g, Li wood 42g, mountain tortoise 13g, Mallotus philippinensis 28g, greyhair cipadessa root or leaf 42g, paint Husband's older sister 28g.Crush,
Sieving, obtains final product.
Clinical test is summarized
1 physical data
This group of patient 89, man 55, female 34；32~58 years old age, average age 42.5 years old；All patients are not with
With clinical symptoms such as the pain in waist and lower extremities of degree, sciatica；This group of patients underwent MRI is checked and made a definite diagnosis, wherein 25 is L3-L4
Prominent, 43 protrude for L4-L5, and 3 protrude for L5-S1, and 3 protrude for L3-L4, L4-L5, and 15 is L4-L5, L5-S1
It is prominent；89 patients find no two just obstacles, and daily walking is not affected significantly.
2 treatment methods
Give the embodiment of the present invention 4 to treat, twice a day, 2 every time, 7 days be a course for the treatment of.
3 curative effect determinate standards
To the assessment reference orthopedics and traumatology of Chinese medicine Illnesses Diagnoses criterion of therapeutical effect of patient's curative effect：
1. fully recover：Image examinations showed protrudes disk Hui Na, and symptom disappears, and leg raising straight is up to more than 80 °；
2. it is effective：Imageological examination shows prominent disk major part Hui Na, and symptom disappears substantially, more than 70 ° of leg raising straight；
3. it is effective：Symptom mitigation, imageological examination shows ledge Hui Na；
4. it is invalid：Iconography has no change, and symptom is without alleviation.
5 results
The efficacy result of table 1
| Recovery from illness | It is effective | Effectively | It is invalid | （%） | |
| Curative effect | 32 | 35 | 20 | 2 | 97.95 |
Clinical effectiveness shows：After being treated to waist dish outstanding patient with the present invention, effective percentage shows that the present invention can have up to 97.75%
Effect treatment waist dish outstanding.
Model case
1st, Lu, female, 56 years old.Master states：Pain in waist and lower extremities more than 6 years, aggravates half a year.Medical history：The patient is in conscious pain in the back before 6 years with right
Have a pain in the leg pain, and intermittence occurs, and nearly half a year aggravates, and through massaging, traction, curative effect is little after dipping and Minimally Invasive Surgery.Vital sign is put down
Surely, head, neck, the heart, lung and abdomen are without exception, walk lamely, and it is positive that waist rolls tenderness between deformity, erector spinae spasm, L4, L5 spinous process.
Very abdomen tests the positive, double straight-leg raising tests and reinforcement negative, goes down without muscular strength, and reflection is normal.CT shows：L4-L5、
L5-S1 waist dish outstandings oppress right neuron root.Diagnosis：L4-L5, L5-S1 lumbar disc herniation.Give implementation of the present invention
Example 1 is treated 2 months, and pain disappears, freedom of movement, follow-up no recurrence in 2 years.
2nd, Lee so-and-so, man, 50 years old.Main suit：Pain in the back 5 years, aggravate with right lower extremity radiating pain, fiber crops repeatedly.Patient's pain in the back is anti-
Recurrence is made, and symptom is gradually aggravated.Give the treatments such as TDP irradiations, closing, it is bad when good during the state of an illness.Checked through lumbar vertebrae CT and shown：L4-
L5 disc herniation pressuring neural root L5- S1 intervertebral disc protrusions, L1-L5 centrums have different degrees of osteoproliferation, lumbar vertebrae life
Reason curvature is straightened.Have a medical check-up：Waist panel is put down, waist both sides muscle tonue, and L4-L5, L5-S1 intervertenral space tenderness are obvious, straight-leg raising test
The positive, strengthens the experiment positive, and bowstring test is positive.2 courses for the treatment of are treated through the embodiment of the present invention 8, pain in the back substantially mitigates, bottom right
Limb pain relief, numbness has been alleviated, 4 courses for the treatment of of continual cure, and coordinates acupuncture, massage treatment, and pain in the back disappears, and activity is certainly
Such as, acroaesthesia fiber crops in bottom right disappear, and consolidate 1 course for the treatment of.Follow-up is not recurred for 1 year.
Although above having used general explanation, specific embodiment and experiment, the present invention is made to retouch in detail
State, but on the basis of the present invention, it can be made some modifications or improvements, this is to those skilled in the art apparent
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (7)
1. a kind of Chinese medicine composition for treating waist dish outstanding, it is characterised in that it is prepared by the Chinese medicine material of following weight portion
：
Erionota thorax (Linne) 5-15 parts, ciliate desert-grass 10-30 parts, Caulis et Folium piperis 25-45 parts, pigeonpea 10-30 parts, 25-45 parts of kwan-yin amaranth, black liana
Certain kind of berries 10-30 parts, champion bauhinia stem 10-30 parts, indian abution root 5-15 parts, 25-45 parts of gymnema sylvestre 10-30 Fen, Li wood, 5-15 parts of mountain tortoise,
Mallotus philippinensis 10-30 parts, greyhair cipadessa root or leaf 25-45 parts, 10-30 parts of Husband's older sister of paint.
2. the Chinese medicine composition of waist dish outstanding is treated as claimed in claim 1, it is characterised in that it is by including following weight
What the Chinese medicine material of amount part was prepared from：
Erionota thorax (Linne) 8-12 parts, ciliate desert-grass 15-25 parts, Caulis et Folium piperis 30-40 parts, pigeonpea 15-25 parts, 30-40 parts of kwan-yin amaranth, black liana
Certain kind of berries 15-25 parts, champion bauhinia stem 15-25 parts, indian abution root 8-12 parts, 30-40 parts of gymnema sylvestre 15-25 Fen, Li wood, 8-12 parts of mountain tortoise,
Mallotus philippinensis 15-25 parts, greyhair cipadessa root or leaf 30-40 parts, 15-25 parts of Husband's older sister of paint.
3. the Chinese medicine composition for the treatment of waist dish outstanding as claimed in claim 1 or 2, it is characterised in that its active component is
Extracted using the ethanol of water extraction or 40-80% concentration expressed in percentage by volumes and be prepared from.
4. the Chinese medicine composition of waist dish outstanding is treated as claimed in claim 3, it is characterised in that its active component is logical
Cross what following methods were prepared from：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times of amount, each extraction time is 1-3 hours, merges extract solution, filtration, relative density when filtrate is concentrated into 70-80 DEG C
It is the clear cream of 1.15-1.20, obtains final product active component.
5. the Chinese medicine composition of waist dish outstanding is treated as claimed in claim 3, it is characterised in that its active component is logical
Cross what following methods were prepared from：Whole medicinal materials are taken, is extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol consumption
It it is 4-10 times of medicinal material total amount, extraction time is 1-4 hours, merges extract solution, is filtered, and filtrate is concentrated into relative at 70-80 DEG C
Density is the clear cream of 1.15-1.20, obtains final product active component.
6. the Chinese medicine composition of waist dish outstanding is treated as claimed in claim 3, it is characterised in that its active component is logical
Cross what following methods were prepared from：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times of amount, each extraction time is 1-3 hours, merges extract solution, filtration, relative density when filtrate is concentrated into 70-80 DEG C
It is the clear cream of 1.15-1.20, adds ethanol, make alcohol content for 40-70%, stand 12-24 hours, filtration, filtrate is concentrated into 70-
Relative density is the medicinal extract of 1.10-1.25 at 80 DEG C, obtains final product active component.
7. a kind of preparation for treating waist dish outstanding, the Chinese medicine composition of the treatment waist dish outstanding as described in claim 1-6
It is prepared from pharmaceutically acceptable carrier combination.
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|---|---|---|---|
| CN2016108628056 | 2016-09-29 | ||
| CN201610862805 | 2016-09-29 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446360A (en) * | 2013-07-11 | 2013-12-18 | 山西师范大学 | Traditional Chinese medicine capsule preparation for treating lumbar disc herniation and preparation method of traditional Chinese medicine capsule preparation |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446360A (en) * | 2013-07-11 | 2013-12-18 | 山西师范大学 | Traditional Chinese medicine capsule preparation for treating lumbar disc herniation and preparation method of traditional Chinese medicine capsule preparation |
Non-Patent Citations (1)
| Title |
|---|
| 汪志刚等: "追活丸治疗腰椎间盘突出症478例的临床观察", 《武汉市首届学术年会论文集》 * |
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