CN106728347A - 一种风湿液及其制备方法 - Google Patents
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Abstract
本发明公开了一种风湿液及其制备方法，将辣椒、独活、黑蜂蜂房、黑蚂蚁、天青地红、红花和狼毒，经二次醇提浓缩后，加入肉桂油，经静置、过滤后得到风湿液，本发明采用纯天然中药材形成的配方，具有祛风除湿，活血通络之效。用于外邪侵袭经络，气血闭阻不畅，引起关节、肢体等处出现酸、麻、肿、痛及屈伸不利等症状，且剂型简单，使用方便，可有效治疗各种风湿疾病。本发明制备工艺简单，对设备要求低，环境友好，适合工业化放大生产。
Description
技术领域
本发明涉及一种中药涂擦剂，特别涉及一种风湿液及其制备方法。
背景技术
风湿病由流行病调查与循证确认为常见病、多发病，且缠绵难愈。带给患者的是无止尽的苦不堪言的病痛折磨。风湿病是一种慢性疾病，此病虽不致命，发作起来却肿痛难忍，严重影响患者的工作和生活，降低了生命质量，目前还没有很好的治疗方法。最新研究表明，风湿病的患病率随着年龄的增大而逐渐升高，男性患病率低于女性，相对寒冷的地区和相对潮湿的沿海地区患病率较高。随着中国社会老龄化程度加深，未来几年将是中国风湿病高发时期。
目前，市面上常见的抗风湿药物，其主要成分以非甾体类抗炎药、类固醇激素口服药等居多，非甾体类抗炎药对胃刺激作用大，类固醇激素长期应用副作用较大，因此综合考虑药效、毒副作用方面，亟需一种天然纯中药的副作用较小的外用液体制剂。
发明内容
本发明的目的在于提供一种风湿液及其制备方法。
为达到上述目的，本发明采用了以下技术方案：
一种风湿液，该液体包括组分A以及组分B，所述组分A由50～200g辣椒、50～200g独活、50～200g蜂房、50～100g黑蚂蚁、20～50g天青地红、20～50g红花以及20～50g狼毒制成，所述组分B为20～50g肉桂油。
优选的，所述组分A由50～100g辣椒、50～100g独活、50～100g蜂房、50～100g黑蚂蚁、20～50g天青地红、20～50g红花以及20～50g狼毒制成，所述组分B为20～50g肉桂油。
优选的，所述组分A由80g辣椒、50g独活、50g蜂房、50g黑蚂蚁、30g天青地红、20g红花以及20g狼毒制成，所述组分B为25g肉桂油。
优选的，所述组分A为采用醇提浓缩法制成的液体，体积为990～1100mL。
优选的，所述蜂房选自蜜蜂蜂房，例如黑蜂(Apis laboriosa Smith)
辣椒符合药典标准，是辣椒的干燥成熟果实，不需要炮制。
上述风湿液的制备方法，包括以下步骤：
将辣椒、独活、蜂房、黑蚂蚁、天青地红、红花以及狼毒用醇提法制得浸提液，将浸提液浓缩得到组分A，将组分B与组分A混合均匀后依次经静置、过滤，得所述风湿液。
所述风湿液的制备方法，具体包括以下步骤：
1)将50～200g辣椒、50～200g独活、50～200g蜂房、50～100g黑蚂蚁、20～50g天青地红、20～50g红花以及20～50g狼毒用5～10倍质量的质量分数50～80％的乙醇水溶液浸提若干次，每次浸提结束后进行过滤，收集每次过滤得到的滤液作为浸提液，将浸提液减压浓缩至990～1100mL，得浓缩液，浓缩液冷却后即为组分A；
2)将20～50g肉桂油加入组分A，搅拌至充分溶解，然后静置12～48小时，静置后进行过滤，得到所述风湿液。
优选的，所述浸提为两次，第一次浸提包括以下步骤：加入所述乙醇水溶液后先于0～30℃冷浸24～48h，然后加热回流1～3h，然后冷却至常温，冷却后过滤得到滤液A；第二次浸提包括以下步骤：向分离滤液A后的滤渣中加入所述乙醇水溶液，然后加热回流1～3h，然后冷却至常温，冷却后过滤得到滤液B；所述浸提液由滤液A、B合并得到。
优选的，所述乙醇水溶液的质量分数为75％。
优选的，所述第一次浸提中，冷浸的时间为24h，冷浸后加热回流3h；第二次浸提中，加入所述乙醇水溶液后加热回流3h。
与现有技术相比，本发明具有以下有益的技术效果：
本发明所述风湿液是根据民间传世验方，依据祖国传统医药学理论，采用现代科学实验研究方法和先进的制剂技术，经多年潜心钻研，研制开发出的具有良好效果的产品。本产品属液体剂型，直接涂擦于不适处，使用简单方便，是用于改善风寒湿痹，特别改善关节、肢体等处酸、麻、肿、痛及屈伸不利等症状。具有祛风除湿，活血通络之功效。本产品为外用涂擦剂型，直接作用于不适处，吸收快。相对于传统风湿病药物，如非甾体类抗炎药、类固醇激素等，无肠胃刺激，无服用西药的毒副作用，作用可靠。
本发明以辣椒、独活、蜂房、黑蚂蚁、天青地红、红花以及狼毒的醇提浓缩液添加肉桂油制成液体，具有制备工艺简单，对设备要求低，环境友好，适合工业化放大生产的优点。
具体实施方式
下面结合实施例对本发明做进一步的详细说明，所述是对本发明的解释而不是限定。
本发明提供一种风湿液，依据组方命名为黑蜂蚁独液。
(一)组方依据以及制备工艺
中医认为风寒湿痹，为行(风)痹、痛(寒)痹、著(湿)痹的合称。因风寒湿三气杂至，致气血瘀滞，证见身重而痛，四肢拘挛，甚则走注疼痛，或手足麻木等。是外邪侵袭经络，气血闭阻不畅，引起关节、肢体等处出现酸、麻、肿、痛及屈伸不利等症状，名为痹证。治宜温经散寒，祛风除湿，活血通络。本发明采用辣椒、肉桂油、独活、黑蜂蜂房、黑蚂蚁、天青地红、红花、狼毒八味纯天然中药配方，本方中辣椒温中散寒、活血消肿，肉桂油散寒止痛、活血通经，二者同为君药，用于温经散寒，活血消肿。独活，祛风除湿，通痹止痛。用于风寒湿痹，腰膝疼痛。蜂房，攻毒杀虫，祛风止痛。二者同为臣药，用于祛风除湿。红花，活血通经，散瘀止痛。用于跌扑损伤，疮疡肿痛。天青地红，活血通经；散瘀消肿。黑蚂蚁，活血通络，消肿解毒。用于风湿性关节炎，疔毒肿痛。狼毒，散结，杀虫。这四味同为佐药，用于通络止痛。
全方君臣佐配合得当，共奏温经散寒，祛风除湿，活血通络之作用。
(二)配方
辅料：75％乙醇(质量分数75％的乙醇水溶液)
(三)制备实例
实例1
(1)将辣椒、独活、黑蜂蜂房、黑蚂蚁、天青地红、红花以及狼毒加入8倍质量60％乙醇中，冷浸24h后加热煮沸，回流3h，然后冷却至常温，过滤。再向滤渣中加入6倍质量60％乙醇，加热煮沸，回流3h，然后冷却至常温，过滤。合并两次滤液，减压浓缩至约1000mL，冷却。
(2)将肉桂油加入步骤1制得的浓缩液中，搅拌至充分溶解。
(3)静置24小时，过滤，成中间品，送检。
(4)灌装(分装10瓶，约100mL/瓶)、外包，成品检验、入库。
实例2
(1)将辣椒、独活、黑蜂蜂房、黑蚂蚁、天青地红、红花以及狼毒加入8倍质量75％乙醇中，冷浸24h后加热煮沸，回流3h，然后冷却至常温，过滤。再向滤渣中加入6倍质量75％乙醇，加热煮沸，回流3h，然后冷却至常温，过滤(两次浸提75％乙醇用量共计4550g)。合并两次滤液，减压浓缩至约1000mL，冷却。
(2)将肉桂油加入步骤1制得的浓缩液中，搅拌至充分溶解。
(3)静置24小时，过滤，成中间品，送检。
(4)灌装(分装10瓶，约100mL/瓶)、外包，成品检验、入库。
实例3
(1)将辣椒、独活、黑蜂蜂房、黑蚂蚁、天青地红、红花以及狼毒加入6倍质量75％乙醇中，冷浸24h后加热煮沸，回流3h，然后冷却至常温，过滤。再向滤渣中加入4倍质量75％乙醇，加热煮沸，回流3h，然后冷却至常温，过滤。合并两次滤液，减压浓缩至约1000mL，冷却。
(2)将肉桂油加入步骤1制得的浓缩液中，搅拌至充分溶解。
(3)静置24小时，过滤，成中间品，送检。
(4)灌装(分装10瓶，约100mL/瓶)、外包，成品检验、入库。
取实例1中提取药渣小样适量用适量75％乙醇提取，浸提液有色，有效成分提取率不高；取实例3中提取药渣小样适量用适量75％乙醇提取，浸提液有色，有效成分提取率不高；取实例2中提取药渣小样适量用适量75％乙醇提取，浸提液几乎无色，有效成分提取率较高。另外，肉桂油在实例2的浓缩液中溶解充分，较实例1和实例3中溶解较好。经过比较，实例2为最佳方案。
(四)用法用量
外用，涂擦不适处，每日1～3次，每次10mL(大约两瓶盖的量)，持续使用20天为一个疗程。
(五)病例使用效果
病例1：
赵某某，女，39岁，类风湿8年。8年来双手关节肿胀，疼痛难忍，冬季重夏季轻。数年来多处求医。不减轻反而重，生活不能自理。多次住院治疗，用药：甲氨蝶呤片、强的松片等药。效不显，出院后每日需吃止痛片。使用风湿液一个疗程，疼痛减轻，不需要再服用止痛剂。使用三个疗程，生活基本上可以自理。
病例2：
王某，女，36岁，类风湿1年，双手及四肢游走性疼痛，小腿遇凉易抽筋，近来发作较频，今年住院13天。病人讲述使用风湿液一个疗程后腿已不抽筋，游走性疼已减轻，继服使用两个疗程，巩固疗效愈。
病例3：
李某某，男，43岁，双手各指关节疼痛僵直3年。病人3年前冬发现双手手指疼痛，怕风，此后逐渐加重，并且晨起手指僵硬，工作劳累或受冷时明显，休息数日可明显缓解，经医院检查被诊为类风湿性关节炎，由于经常工作，病不得养而久治不愈，双手指关节均已肿大变形，两拇指明显，且不敢用力，晨僵，活动后可减轻，遇风则痛，对凉很敏感。后来使用风湿液一个疗程，手指晨僵缓解，疼痛明显缓解，继续使用两个疗程，指关节恢复正常。
病例4：
***，女，38岁。患类风湿8年。现已卧床，全身多关节肿痛僵硬，双上肢屈曲位，肌肉萎缩。双膝及踝关节肿痛，下蹲受限，面色苍白，形体消瘦，大小便需在家人的帮助下完成。使用风湿液两个疗程，疼痛明显缓解，关节消肿，继续使用两个疗程，可以下地行走。
病例5：
张某某，女，56岁，患类风湿1年多，几个月前因受凉渐发生右手中指近端指关节肿胀疼痛，约20天左右迅速波及全身多关节，呈对称性，以四肢小关节明显，伴关节晨僵。病变关节畏寒，酸痛，遇阴雨天加重。精神差，双手握力差，双手腕、膝、踝及手指关节肿胀，压痛。使用风湿液一个疗程，关节晨僵缓解，酸痛缓解。继续使用两个疗程，双手腕、膝、踝及手指等关节恢复正常。
总之，本发明所述风湿液采用天然中药配方，能够有效温经散寒，祛风除湿，活血通络。用于外邪侵袭经络，气血闭阻不畅，引起的关节、肢体等处出现酸、麻、肿、痛及屈伸不利等症状，且剂型简单，使用方便，可有效治疗各种风湿疾病，使用安全方便。
Claims (10)
1.一种风湿液，其特征在于：包括组分A以及组分B，所述组分A由50～200g辣椒、50～200g独活、50～200g蜂房、50～100g黑蚂蚁、20～50g天青地红、20～50g红花以及20～50g狼毒制成，所述组分B为20～50g肉桂油。
2.根据权利要求1所述一种风湿液，其特征在于：所述组分A由50～100g辣椒、50～100g独活、50～100g蜂房、50～100g黑蚂蚁、20～50g天青地红、20～50g红花以及20～50g狼毒制成，所述组分B为20～50g肉桂油。
3.根据权利要求1所述一种风湿液，其特征在于：所述组分A由80g辣椒、50g独活、50g蜂房、50g黑蚂蚁、30g天青地红、20g红花以及20g狼毒制成，所述组分B为25g肉桂油。
4.根据权利要求1所述一种风湿液，其特征在于：所述组分A为采用醇提浓缩制成的液体，体积为990～1100mL。
5.根据权利要求1所述一种风湿液，其特征在于：所述蜂房选自蜜蜂蜂房。
6.如权利要求1所述风湿液的制备方法，其特征在于：包括以下步骤：
将辣椒、独活、蜂房、黑蚂蚁、天青地红、红花以及狼毒用醇提法制得浸提液，将浸提液浓缩得到组分A，将组分B与组分A混合均匀后依次经静置、过滤，得所述风湿液。
7.根据权利要求6所述的方法，其特征在于：所述风湿液的制备方法，具体包括以下步骤：
1)将50～200g辣椒、50～200g独活、50～200g蜂房、50～100g黑蚂蚁、20～50g天青地红、20～50g红花以及20～50g狼毒用5～10倍质量的质量分数50～80％的乙醇水溶液浸提若干次，每次浸提结束后进行过滤，收集每次过滤得到的滤液作为浸提液，将浸提液减压浓缩至990～1100mL，得浓缩液，浓缩液冷却后即为组分A；
2)将20～50g肉桂油加入组分A，搅拌至充分溶解，然后静置12～48小时，静置后进行过滤，得到所述风湿液。
8.根据权利要求7所述的方法，其特征在于：所述浸提为两次，第一次浸提包括以下步骤：加入所述乙醇水溶液后先于0～30℃冷浸24～48h，然后加热回流1～3h，然后冷却至常温，冷却后过滤得到滤液A；第二次浸提包括以下步骤：向分离滤液A后的滤渣中加入所述乙醇水溶液，然后加热回流1～3h，然后冷却至常温，冷却后过滤得到滤液B；所述浸提液由滤液A、B合并得到。
9.根据权利要求8所述的方法，其特征在于：所述乙醇水溶液的质量分数为75％。
10.根据权利要求8所述的方法，其特征在于：所述第一次浸提中，冷浸的时间为24h，冷浸后加热回流3h；第二次浸提中，加入所述乙醇水溶液后加热回流3h。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146343A (zh) * | 1995-09-25 | 1997-04-02 | 石建民 | 一种治疗椎间盘病的外敷膏 |
| CN101856426A (zh) * | 2010-06-11 | 2010-10-13 | 张兆俊 | 一种治疗风湿性关节炎的药物及其制作方法 |
| CN102274252A (zh) * | 2011-08-11 | 2011-12-14 | 张晋瑞 | 治疗类风湿病的野木瓜外用制剂及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN101856426A (zh) * | 2010-06-11 | 2010-10-13 | 张兆俊 | 一种治疗风湿性关节炎的药物及其制作方法 |
| CN102274252A (zh) * | 2011-08-11 | 2011-12-14 | 张晋瑞 | 治疗类风湿病的野木瓜外用制剂及其制备方法 |
Cited By (1)
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|---|---|---|---|---|
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