CN106726757A - A kind of peony seed oil micro emulsion gels and preparation method thereof - Google Patents

A kind of peony seed oil micro emulsion gels and preparation method thereof Download PDF

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CN106726757A
CN106726757A CN201611200213.4A CN201611200213A CN106726757A CN 106726757 A CN106726757 A CN 106726757A CN 201611200213 A CN201611200213 A CN 201611200213A CN 106726757 A CN106726757 A CN 106726757A
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seed oil
peony seed
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CN106726757B (en
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王小宁
罗国平
闫梦茹
张存劳
马远涛
李伟泽
杨黎彬
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Xian Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/068—Microemulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Life Sciences & Earth Sciences (AREA)
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  • Gerontology & Geriatric Medicine (AREA)
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Abstract

It is composed of the following components according to weight portion the invention discloses a kind of peony seed oil micro emulsion gels：15 parts of polyoxyethylene aliphatic alcohol ether, 0.5 3 parts of polyethylene glycol hydrogenated lanolin, 3 10 parts of saualane, 1 10 parts of peony seed oil, 0.5 3 parts of silicone, 15 parts of glycerine, 46 parts of trehalose, 0.01 2.0 parts of Sodium Hyaluronate, 10 20 parts of deionized water.Its preparation method is：Peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone are mixed, is added in the mixture of glycerine, trehalose, Sodium Hyaluronate, deionized water, homogenization after ultrasound continues stirring and obtains.Preparation method in the present invention is that ultrasonic emulsification and high-pressure homogeneous emulsification are combined, and prepares that micro emulsion gels particle is more tiny, and feel is fine and smooth, it is easy to is coated with and penetrates into skin and absorbed.

Description

A kind of peony seed oil micro emulsion gels and preparation method thereof
Technical field
It is male the invention further relates to this invention belongs to cosmetic field, and in particular to a kind of peony seed oil micro emulsion gels The preparation method of red seed oil microemulsion gel.
Background technology
Peony seeds are the seeds of Ranunculaceae Paeonia machaka tree peony.Peony seed oil extract from peony seeds A kind of golden transparent oily substance.Up to more than 90%, wherein (ω -3 is alpha-linolenic acid peony seed oil unsaturated fatty acid content Row) content more than 40%, be 120 times of olive oil.Modern study shows that peony seed oil has Nutrition and health function higher：Drop Blood fat, antioxidation, hepatoprotective effect, hypoglycemic, raising immunity of organisms, radioresistance, sun-proof Bearberry Extract.Tree peony The strong anti-oxidant, radioresistance of seed oil and whitening function can effectively prevent wrinkle of skin from producing and the brown material buildup of fat, promote skin Regeneration and epithelial tissue heal, thus peony seed oil is increasingly becoming the study hotspot of cosmetic field.Application No. 201510976466.X Chinese patent (the applyings date：2015.12.21, publication number：CN105411882A, publication date： 2016.3.23) disclose a kind of using paeonol, peony essential oil, peony seed oil skin care compositions, can obviously improve epiderm skin Cell cycle function, promotes the microcirculation of capillary of skin, and delay skin aging process has moisturizing whitening function.Shen Please number be the 201510558450.7 Chinese patent (applyings date：2015.9.6, publication number：CN105078875A, publication date： 2015.11.25 a kind of cosmetics containing peony extract) are disclosed, is carried containing peony seed oil, peony seeds in the tree peony cosmetics Thing, peony root extractive are taken, is wherein in common emulsion droplet form with good anti-inflammatory, anti-aging effects, but peony seed oil Lost activity in the presence of, it is easy to oxidation by air, product stability is not enough, and the conduct of stereth -2 is with the addition of in matrix Emulsifying agent, easily causes allergic, and has the possibility for triggering pimples, is not particularly suited for cosmetic base.
The emulsion that micro emulsion is particle diameter less than 100nm, micro emulsion cosmetics have that stability is high, particle diameter is small, easy quilt The advantages of skin absorption, feel are fine and smooth, and micro emulsion lacks adhesion, the holdup time is short on skin, it is further made solidifying Jelly, is conducive to extending its action time, and gel sense of touch is salubrious, moisten, be easy to coating, is extensively liked by consumer. By peony seed oil microemulsified and it is made its gel there is not been reported in the application of cosmetic field at present.
The content of the invention
It is an object of the invention to provide a kind of peony seed oil micro emulsion gels, micro emulsion and gel are combined, it is not greasy Sense, can quickly absorb, and stability is high, uses matrix safe and nontoxic.
It is a further object to provide a kind of preparation method of peony seed oil micro emulsion gels.
The technical solution adopted in the present invention is, a kind of peony seed oil micro emulsion gels, according to weight portion by following components Composition：Polyoxyethylene aliphatic alcohol ether 1-5 parts, polyethylene glycol hydrogenated lanolin 0.5-3 parts, saualane 3-10 parts, peony seed oil 1- 10 parts, silicone 0.5-3 parts, glycerine 1-5 parts, trehalose 4-6 parts, Sodium Hyaluronate 0.01-2.0 parts, deionized water 10-20 parts.
Another technical scheme of the present invention is, a kind of preparation method of peony seed oil micro emulsion gels, specifically Implement according to following steps：
Step 1, weighs following components respectively by weight：Polyoxyethylene aliphatic alcohol ether 1-5 parts, polyethylene glycol hydrogenated wool It is fat 0.5-3 parts, saualane 3-10 parts, peony seed oil 1-10 parts, silicone 0.5-3 parts, glycerine 1-5 parts, trehalose 4-6 parts, transparent Matter 0.01-2.0 parts, deionized water 10-20 parts of sodium of acid；
Step 2, peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone are mixed, Temperature is heated to for 70-80 DEG C, stirring 20-40min is designated as material I up to being completely dissolved；
Step 3, stirs until completely after glycerine, trehalose, Sodium Hyaluronate, deionized water are mixed at 70-75 DEG C Dissolving, is designated as material II；
Step 4, material I is slowly added into island material II, it is stirring while adding it is uniform after, it is ultrasonically treated to form uniform breast Agent；
Step 5, stirs after the emulsion homogenization that step 4 is obtained, and is subsequently cooled to room temperature, obtains peony seed oil micro emulsion Gel.
The features of the present invention is also resided in,
Power 10-20W ultrasonically treated in step 4, the time is 1-5min.
Homogenization is that emulsion carries out homogeneous 5-20min by high pressure homogenizer under 500-1000bar in step 5.
Mixing time is 15-20min in step 5.
The beneficial effects of the invention are as follows, first, micro emulsion belongs to thermodynamic stability system, because emulsion particle diameter is smaller, and It is dispersed in gel-type vehicle, it is more difficult to be combined into macromolecular between drop so as to separate out, therefore micro emulsion cosmetics compare generalization Cosmetic possesses more preferable stability；Secondly as the solubilization of micro emulsion, containing for peony seed oil in product system can be increased Amount, the shortcoming for overcoming ordinary cosmetics oil content higher and unstable；In addition, the preparation method in the present invention is ultrasonic emulsification Combined with high-pressure homogeneous emulsification, it is more tiny to prepare micro emulsion gels particle, feel is fine and smooth, it is easy to be coated with and penetrate into skin and Absorbed.Micro emulsion gels in the present invention can be widely applied to the cosmetic fields such as skin care item, shampoo, facial mask.
Brief description of the drawings
Fig. 1 is the grain size distribution of the peony seed oil micro emulsion obtained by embodiment 1-3；
Fig. 2 is the aspect graph of the peony seed oil micro emulsion gels obtained by embodiment 1-3；
Fig. 3 is the percentage of water loss result of the test of the peony seed oil micro emulsion gels obtained by embodiment 1-3.
Specific embodiment
The present invention is described in detail with reference to the accompanying drawings and detailed description.
Peony seed oil micro emulsion gels of the present invention, it is composed of the following components according to weight portion：Polyoxyethylene aliphatic alcohol ether 1-5 Part, polyethylene glycol hydrogenated lanolin 0.5-3 parts, saualane 3-10 parts, peony seed oil 1-10 parts, silicone 0.5-3 parts, glycerine 1-5 Part, trehalose 4-6 parts, Sodium Hyaluronate 0.01-2.0 parts, deionized water 10-20 parts.
The preparation method of above-mentioned peony seed oil micro emulsion gels, specifically implements according to following steps：
Step 1, weighs following components respectively by weight：Polyoxyethylene aliphatic alcohol ether 1-5 parts, polyethylene glycol hydrogenated wool It is fat 0.5-3 parts, saualane 3-10 parts, peony seed oil 1-10 parts, silicone 0.5-3 parts, glycerine 1-5 parts, trehalose 4-6 parts, transparent Matter 0.01-2.0 parts, deionized water 10-20 parts of sodium of acid；
Step 2, peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone are mixed, Temperature is heated to for 70-80 DEG C, stirring 20-40min is designated as material I up to being completely dissolved；
Step 3, stirs until completely after glycerine, trehalose, Sodium Hyaluronate, deionized water are mixed at 70-75 DEG C Dissolving, is designated as material II；
Step 4, material I is slowly added into island material II, it is stirring while adding it is uniform after, ultrasonically treated 1- under 10-20W 5min, forms uniform emulsion；
Step 5, the emulsion that step 4 is obtained carries out homogeneous 5-20min by high pressure homogenizer under 500-1000bar, Then proceed to stir 15-20min, be subsequently cooled to room temperature, obtain peony seed oil micro emulsion gels.
Embodiment 1
Peony seed oil micro emulsion gels are composed of the following components according to weight portion：
Preparation method, including following steps：
(1) peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone are weighed successively, Above-mentioned raw material is sequentially added the beaker of dried and clean, temperature is heated to for 80 DEG C, stirring 30 minutes is until be completely dissolved, note It is material I；
(2) separately take dried and clean beaker, glycerine, trehalose, Sodium Hyaluronate, deionized water weighed successively, by raw material according to Secondary addition, stirring is designated as material II up to being completely dissolved at 75 DEG C；
(3) material I is slowly added into material II, stirring while adding, ultrasound 2 minutes is to forming uniform emulsion under 15W；
(4) above-mentioned emulsion is carried out into homogeneous 15 minutes by high pressure homogenizer under 1000bar；
(5) treat that the material in step (4) continues to stir 15 minutes, be cooled to normal temperature, discharge, obtain finished product.
Embodiment 2
Peony seed oil micro emulsion gels are composed of the following components according to weight portion：
Preparation method, including following steps：
(1) peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone are weighed successively, Above-mentioned raw material is sequentially added the beaker of dried and clean, temperature is heated to for 75 DEG C, stirring 30 minutes is until be completely dissolved, note It is material I；
(2) separately take dried and clean beaker, glycerine, trehalose, Sodium Hyaluronate, deionized water weighed successively, by raw material according to Secondary addition, stirring is designated as material II up to being completely dissolved at 70 DEG C；
(3) material I is slowly added into material II, stirring while adding, ultrasound 3 minutes is to forming uniform emulsion under 10W；
(4) above-mentioned emulsion is carried out into homogeneous 20 minutes by high pressure homogenizer under 800bar；
(5) treat that the material in step (4) continues to stir 15 minutes, be cooled to normal temperature, discharge, obtain finished product.
Embodiment 3
Peony seed oil micro emulsion gels are composed of the following components according to weight portion：
Preparation method, including following steps：
(1) peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone are weighed successively, Above-mentioned raw material is sequentially added the beaker of dried and clean, temperature is heated to for 80 DEG C, stirring 30 minutes is until be completely dissolved, note It is material I；
(2) separately take dried and clean beaker, glycerine, trehalose, Sodium Hyaluronate, deionized water weighed successively, by raw material according to Secondary addition, stirring is designated as material II up to being completely dissolved at 75 DEG C；
(3) material I is slowly added into material II, stirring while adding, ultrasound 1 minute is to forming uniform emulsion under 15W；
(4) above-mentioned emulsion is carried out into homogeneous 20 minutes by high pressure homogenizer under 600bar；
(5) treat that the material in step (4) continues to stir 15 minutes, be cooled to normal temperature, discharge, obtain finished product.
Embodiment 4
Peony seed oil micro emulsion gels are composed of the following components according to weight portion：
Preparation method, including following steps：
(1) peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone are weighed successively, Above-mentioned raw material is sequentially added the beaker of dried and clean, temperature is heated to for 70 DEG C, stirring 20 minutes is until be completely dissolved, note It is material I；
(2) separately take dried and clean beaker, glycerine, trehalose, Sodium Hyaluronate, deionized water weighed successively, by raw material according to Secondary addition, stirring is designated as material II up to being completely dissolved at 72 DEG C；
(3) material I is slowly added into material II, stirring while adding, ultrasound 4 minutes is to forming uniform emulsion under 20W；
(4) above-mentioned emulsion is carried out into homogeneous 5 minutes by high pressure homogenizer under 500bar；
(5) treat that the material in step (4) continues to stir 20 minutes, be cooled to normal temperature, discharge, obtain finished product.
Embodiment 5
Peony seed oil micro emulsion gels are composed of the following components according to weight portion：
Preparation method, including following steps：
(1) peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone are weighed successively, Above-mentioned raw material is sequentially added the beaker of dried and clean, temperature is heated to for 75 DEG C, stirring 40 minutes is until be completely dissolved, note It is material I；
(2) separately take dried and clean beaker, glycerine, trehalose, Sodium Hyaluronate, deionized water weighed successively, by raw material according to Secondary addition, stirring is designated as material II up to being completely dissolved at 70 DEG C；
(3) material I is slowly added into material II, stirring while adding, ultrasound 5 minutes is to forming uniform emulsion under 18W；
(4) above-mentioned emulsion is carried out into homogeneous 10 minutes by high pressure homogenizer under 900bar；
(5) treat that the material in step (4) continues to stir 18 minutes, be cooled to normal temperature, discharge, obtain finished product.
Peony seed oil micro emulsion gels of the present invention are tested below by dependence test experiment, to illustrate its performance.
(1) particle diameter after measured of peony seed oil micro emulsion gels obtained in embodiment 1-3, distribution map is shown in Fig. 1, is inverted micro- Microscopic observation micro emulsion form, is shown in Fig. 2.Can be seen that the average particle size distribution of peony seed oil micro emulsion is left in 38.02nm by Fig. 1, Fig. 2 The right side, form is uniform spheroidal.
(2) the physical stability experiment of peony seed oil micro emulsion gels
Appropriate centrifugation 20 minutes under 5000r/min rotating speeds of peony seed oil micro emulsion gels of the present invention are taken, profit point is had no Layer takes under the conditions of this product is respectively placed in 10,25,40,60 DEG C in right amount and stores 10 days, and micro emulsion gels have no profit point during storage Layer, and emulsion droplet size distribution is without significant change.
(3) moisture retention experiment
Under the conditions of 25 DEG C of temperature, humidity 40%, 0.22 μm of miillpore filter 4 is taken, be placed in fluid-tight pair of silicon paper, point 5 are not added dropwise on filter membrane and drip purified water, weigh immediately.The tree peony of even spread embodiment 1-3 is then distinguished on 1-3 filter membranes Seed oil microemulsion gel, weighs immediately, and No. 4 films are not coated with, as a control group.Then surveyed respectively at 5,15,30,60,120 minutes Determine the percentage of water loss of 1-4 filter membranes.Percentage of water loss computing formula is as follows：
Wherein, MnIt is sample weight after placement, MoIt is sample weight before placing.
Result is shown in Fig. 3, and the filter membrane percentage of water loss of embodiment 1-3 groups is can be seen that significantly lower than control group, table by Fig. 3 results The bright obtained peony seed oil micro emulsion gels of the present invention have preferable moistening effect, can effectively improve skin elasticity, promote skin Skin aquation is so as to further increase the transdermal penetration of grease.
(4) the coating experiment of peony seed oil micro emulsion gels
The peony seed oil micro emulsion gels and appropriate peony seed oil of Example 1-3, coat double silicon papers (with class respectively Be similar to the hydrophobicity of skin) on observed, the coating process of peony seed oil micro emulsion gels is found easily, and without oil droplet coalescence Phenomenon, and be coated with after peony seed oil, there is oil droplet coalescence quickly in double silicon paper surfaces, not easy to apply uniform, illustrate tree peony Seed oil is conducive to coating skin after being prepared into micro emulsion gels, is more beneficial for it and is fully contacted promotion absorption with skin, and Reduce greasy feeling.This product using the made composition of raw materials of embodiment 1-3 through being conventionally prepared into micro emulsion gels as reality Test and use sample, it is on probation through the female volunteers of 30 18-45 Sui, feel salubriouser, it is easy to be coated with, without greasy feeling.

Claims (5)

1. a kind of peony seed oil micro emulsion gels, it is characterised in that composed of the following components according to weight portion：Polyoxyethylene fatty Alcohol ether 1-5 parts, polyethylene glycol hydrogenated lanolin 0.5-3 parts, saualane 3-10 parts, peony seed oil 1-10 parts, silicone 0.5-3 parts, Glycerine 1-5 parts, trehalose 4-6 parts, Sodium Hyaluronate 0.01-2.0 parts, deionized water 10-20 parts.
2. a kind of preparation method of peony seed oil micro emulsion gels, it is characterised in that specifically implement according to following steps：
Step 1, weighs following components respectively by weight：Polyoxyethylene aliphatic alcohol ether 1-5 parts, polyethylene glycol hydrogenated lanolin 0.5-3 parts, saualane 3-10 parts, peony seed oil 1-10 parts, silicone 0.5-3 parts, glycerine 1-5 parts, trehalose 4-6 parts, hyalomitome Sour sodium 0.01-2.0 parts, deionized water 10-20 parts；
Step 2, peony seed oil, polyoxyethylene aliphatic alcohol ether, polyethylene glycol hydrogenated lanolin, saualane, silicone is mixed, heating It it is 70-80 DEG C to temperature, stirring 20-40min is designated as material I up to being completely dissolved；
Step 3, stirs up to being completely dissolved after glycerine, trehalose, Sodium Hyaluronate, deionized water are mixed at 70-75 DEG C, It is designated as material II；
Step 4, material I is slowly added into island material II, it is stirring while adding it is uniform after, it is ultrasonically treated to form uniform emulsion；
Step 5, stirs after the emulsion homogenization that step 4 is obtained, and is subsequently cooled to room temperature, obtains peony seed oil micro emulsion gel Agent.
3. the preparation method of peony seed oil micro emulsion gels according to claim 2, it is characterised in that ultrasound in step 4 The power 10-20W for the treatment of, the time is 1-5min.
4. the preparation method of peony seed oil micro emulsion gels according to claim 2, it is characterised in that homogeneous in step 5 Treatment is that emulsion carries out homogeneous 5-20min by high pressure homogenizer under 500-1000bar.
5. the preparation method of the peony seed oil micro emulsion gels according to claim 2 or 4, it is characterised in that stirred in step 5 The time is mixed for 15-20min.
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CN108685992A (en) * 2018-07-31 2018-10-23 上品（洛阳）牡丹产业有限公司 A kind of tree peony flower seed oil stoste and preparation method thereof with cell repair function
CN113116755A (en) * 2021-05-27 2021-07-16 山东花物堂生物科技有限公司 Skin care composition for promoting penetration and preparation method and application thereof
CN114533647A (en) * 2022-03-31 2022-05-27 广州旭妆生物科技有限公司 Silicon oil-free anti-dandruff shampoo composition and preparation method thereof

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谢明华等: "微乳凝胶经皮给药制剂的研究与应用进展", 《中国现代应用药学》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108685992A (en) * 2018-07-31 2018-10-23 上品（洛阳）牡丹产业有限公司 A kind of tree peony flower seed oil stoste and preparation method thereof with cell repair function
CN108685992B (en) * 2018-07-31 2021-03-02 上品（洛阳）牡丹产业有限公司 Peony seed oil stock solution with cell repairing function and preparation method thereof
CN113116755A (en) * 2021-05-27 2021-07-16 山东花物堂生物科技有限公司 Skin care composition for promoting penetration and preparation method and application thereof
CN114533647A (en) * 2022-03-31 2022-05-27 广州旭妆生物科技有限公司 Silicon oil-free anti-dandruff shampoo composition and preparation method thereof

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