CN106720379A - A kind of hunchbacked blood polypeptide milk piece and preparation method thereof - Google Patents
A kind of hunchbacked blood polypeptide milk piece and preparation method thereof Download PDFInfo
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- CN106720379A CN106720379A CN201611102743.5A CN201611102743A CN106720379A CN 106720379 A CN106720379 A CN 106720379A CN 201611102743 A CN201611102743 A CN 201611102743A CN 106720379 A CN106720379 A CN 106720379A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/18—Milk in dried and compressed or semi-solid form
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/06—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from blood
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C2240/00—Use or particular additives or ingredients
- A23C2240/15—Use of plant extracts, including purified and isolated derivatives thereof, as ingredient in dairy products
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Abstract
The invention discloses a kind of hunchbacked blood polypeptide milk piece, the mass fraction shared by component that the milk piece is included and each component is：50 ~ 1000 parts of hunchbacked blood polypeptide powder, 50 ~ 1000 parts of milk powder, 50 ~ 1000 parts of grape seed extract, 50 ~ 1000 parts of Tea Polyphenols, 50 ~ 1000 parts of filler, 1 ~ 500 part of binder, 1 ~ 500 part of flavouring, 1 ~ 500 part of flavouring agent, 1 ~ 500 part of lubricant, 1 ~ 500 part of coating powder；The preparation method of grape seed extract：With grape pip as raw material, grape pip powder is first broken to 10 ~ 200 mesh, add water, shearing or homogeneous broken wall, 70 μm are less than to grape pip particle, add the mixed solution of one kind or the different proportion composition in ethanol or ethyl acetate, extracted 0.1~36 hour at a temperature of 20~90 DEG C, filtering, concentration, spray drying or freeze-drying obtain grape seed extract.The invention also discloses the preparation method of hunchbacked blood polypeptide milk piece.Instant invention overcomes because in hunchbacked blood polypeptide containing substantial amounts of hydrophilic group and hydrophobic group caused by Storage and stability difference technical problem, enhance product stability.
Description
Technical field
The invention belongs to functional food preparing technical field, it is related to a kind of hunchbacked blood polypeptide milk piece and preparation method thereof.
Background technology
Modern study shows that utilization of the mankind to protein is that protein digestion is absorbed into polypeptide, participates in human body
Metabolism and immunomodulatory action.Polypeptide has many advantages, such as：It is not required to digest directly absorption, is not required to consume body energy, absorbs
Speed is fast, preferential absorption, and the speed of synthetic protein is fast compared with amino acid in human body.Therefore, it is adapted to the preferable product of people's consumption
Product are polypeptides.Numerous studies prove that polypeptide has immune, anti-oxidant auxiliary adjustment, removing free radical, improves Nitrogen Absorption and ore deposit
Many bioactivity such as matter transportation, promotion growth.
Hunchbacked blood polypeptide is the short chain material being made up of amino acid residue molecular that hunchbacked blood is obtained through protease hydrolytic.Due to white horse with a black mane
Hunchbacked living environment is severe, and the composition in its blood is also substantially different from other animals.Nutritional studies are proved, except basal nutrient work(
Beyond the various amino acid of energy balance, absorption of human body are fast, hunchbacked blood polypeptide has multiple biological activities to the physiological Mechanism of human body.By camel
Blood polypeptide exploitation is a kind of food, is conducive to the health of masses, meets current consumption tide, is the development of future polypeptide grocery trade
New direction.Meanwhile, the exploitation of hunchbacked blood polypeptide is greatly improved the added value of hunchbacked blood, deepens and widened what hunchbacked blood was developed
Breadth and depth.
Polypeptide has stronger moisture absorption, and product is perishable, reduced shelf-life.Using packaging technique, can greatly improve
The stability of product.Milk piece as a kind of simply eaten, easy to carry, easy to maintain edible way, by more and more
People like.Using milk piece as carrier, certain oxidation-resistant active ingredient is properly added, is made the milk piece with healthcare function,
Body immunity, and nutrition delicious food, instant edible can be strengthened.Therefore, compared with normal food, milk piece can more cater to consumption
Person's multiple demands, win initiative in increasingly fierce Market Competition.
The content of the invention
It is an object of the invention to provide a kind of hunchbacked blood polypeptide milk piece and preparation method thereof.
Hunchbacked blood polypeptide milk piece of the present invention is overcome because being made containing substantial amounts of hydrophilic group and hydrophobic group in hunchbacked blood polypeptide
Into Storage and the technical problem of stability difference, product stability is enhanced.Meanwhile, modern allegro city is met in component
The demand of life and aging society people to functional food.
A kind of hunchbacked blood polypeptide milk piece, it is characterised in that the mass fraction shared by component that the milk piece is included and each component
For：50 ~ 1000 parts of hunchbacked blood polypeptide powder, 50 ~ 1000 parts of milk powder, 50 ~ 1000 parts of grape seed extract, 50 ~ 1000 parts of Tea Polyphenols, fill out
Fill 50 ~ 1000 parts of agent, 1 ~ 500 part of binder, 1 ~ 500 part of flavouring, 1 ~ 500 part of flavouring agent, 1 ~ 500 part of lubricant, coating powder 1
~ 500 parts；The preparation method of the grape seed extract：With grape pip as raw material, grape pip powder is first broken to 10 ~ 200 mesh, plus
Enter water, the addition of water is that water and grape pip mass ratio are 1:1 ~ 200, shear or homogeneous broken wall, it is less than 70 to grape pip particle
μm, add the mixed solution of one kind in ethanol or ethyl acetate or different proportion composition, the addition of solution for solution with
Grape pip mass ratio is 1:1 ~ 300, extracted 0.1~36 hour at a temperature of 20~90 DEG C, filtering, concentration, spray drying or cold
Jelly is dried to obtain grape seed extract.
The preparation method of the hunchbacked blood polypeptide：With hunchbacked blood as raw material, adjusted with ammoniacal liquor, acetic acid, hydrochloric acid or sodium hydroxide solution
PH value is 2 ~ 10, adds ethanol to carry out alcohol precipitation, and the addition of ethanol is hunchbacked blood and the mass ratio of ethanol is 1:1 ~ 100, stirring 0.5
~ 6 hours, 1 ~ 48 hour is stood, add water to make solution with 1000 ~ 20000 revs/min of centrifugation 0.1 ~ 6 hour, in precipitation
Mass concentration be 5% ~ 60%, and be adjusted to 1 ~ 12 with ammoniacal liquor, acetic acid, hydrochloric acid or sodium hydroxide solution pH value, add protein water
Solution enzyme, the addition of enzyme is 1 with hunchbacked blood mass ratio for enzyme:5 ~ 3000, digested 0.2~48 hour at 20~70 DEG C, concentration, then spray
Mist is dried or freeze-drying obtains hunchbacked blood polypeptide.
The proteolytic enzyme is in serine protease, thiol protease, metalloproteinases or carboxyl protease
The mixture of one or more.
The milk powder is any one or several mixtures of whole milk powder, skimmed milk power and sour milk powder.
The filler is lactose, sucrose, glucose, fructose, mannitol, sorbierite, xylitol, microcrystalline cellulose, shallow lake
Any one in powder, hydroxypropyl cellulose, superfine silica gel powder or several mixtures.
The binder is ethanol, water, 0.1% ~ 20% polyethylene glycol, 0.1% ~ 20% polyvinylpyrrolidone ethanol or water-soluble
Liquid, 0.1% ~ 20% methylcellulose ethanol or the aqueous solution, 0.1% ~ 20% ethyl cellulose ethanol or the aqueous solution, 0.1% ~ 20% hydroxypropyl
Any one in base cellulosic ethanol or the aqueous solution, 0.1% ~ 20% sodium carboxymethylcellulose ethanol or the aqueous solution, dextrin, starch
Or several mixtures.
The flavouring is steviol glycoside, rebaudioside A, Aspartame, vitamin C, protein sugar, Sucralose, lemon
Acid, lactic acid, malic acid, D-sorbite, mannitol, maltitol, hydroxyl isomaltulose, saccharin sodium, honey element, alitame, knob
Sweet, acesulfame potassium any one or several mixtures.
The flavouring agent is Mint Essence, flavoring orange essence, butter essence, lemon extract, flavoring pineapple essence, mango essence, black
Certain kind of berries essence, blueberry flavor, strawberry essence, raspberry essence, cherry essence, grape essence, blackcurrant essence, orange flavor, grapefruit
Essence, flavoring apple essence, peach essence, pear essence, apricot essence, hawthorn essence, cocoanut flavour, small wheat essence, barley essence, lichee are fragrant
Essence, oat essence, corn essence, sorghum essence, buckwheat essence, beans essence any one or it is several.
The lubricant is any one in magnesium stearate, stearic acid, superfine silica gel powder, talcum powder, Stepanol MG
Plant or several mixtures.
The coating powder is colored coating powder.
The preparation method of camel blood polypeptide milk piece, comprises the following steps as described above：
1）Sterilizing：By preparation with raw material sterilized；
2）Premix：Sterilized 50 ~ 1000 parts of hunchbacked blood polypeptide powder, 50 ~ 1000 parts of milk powder, grape pip are weighed according to mass fraction to carry
Take 50 ~ 1000 parts of thing, 50 ~ 1000 parts of Tea Polyphenols, 50 ~ 1000 parts of filler, 1 ~ 500 part of binder, 1 ~ 500 part of flavouring, perfume
Taste agent is 1 ~ 500 part, 1 ~ 500 part of lubricant, 1 ~ 500 part of coating powder, and hunchbacked blood polypeptide powder, milk powder, grape seed extract, tea is more
Phenol, filler and flavouring cross 60 ~ 200 mesh sieves, well mixed to be made pre-mixture；
3）Granulation：Binder is made solution with ultrasonically treated, step 2 is uniformly sprayed onto）Made in prepared pre-mixture
Into material；Adjustment humidity of materials to moisture content is 0.2% ~ 20%（Holding is agglomerating, and dissipating for touching is advisable）, material is crossed into 5 ~ 60 mesh sieves
Net, dries, and drying temperature is 25~100 DEG C；
4）Whole grain：The material of caking is opened in stranding, is allowed to be dispersed into uniform particle, and sieving whole grain was 5 ~ 60 mesh, was dried, particle water
Sub-control system is made whole grain material 1~10%；
5）Compressing tablet：Flavouring agent is weighed, flavouring agent ethanol or the aqueous solution is configured to, is placed in ultrasound bath, ultrasound is uniform；Will profit
Lubrication prescription and the flavouring agent for preparing are added separately to whole grain material, are well mixed, then compressing tablet；
6）It is coated：Under stirring, coating powder is configured to the coating solution that concentration is 1% ~ 50% with 50% ~ 95% ethanol；Will step
Rapid 5）The pelletizing temperature being made is heated to 30 ~ 70 DEG C, sprays into coating solution, until it is consistent to reach unilateral uniform color, then 25 ~
Hunchbacked blood polypeptide milk piece is obtained after 100 DEG C of dryings.
Step 1）Described in sterilizing methods using Co60 radiation sterilization, ultraviolet irradiation sterilizing, thimerosal gasification sterilizing, it is micro-
Ripple sterilizing, ethanol immersion sterilizing or spray drying sterilizing.
The binder solvent is ethanol, water or two kinds of solution combinations.
The hunchbacked blood polypeptide milk piece is circular piece, ellipse, annular, triangle or rhombus.
Effect of above-mentioned each key component and effect：
Described hunchbacked blood polypeptide is that the natural polypeptides for preparing is digested from hunchbacked blood.Because camel existence is in harsh severe ring
Under the conditions of border, special environment makes its blood compared with the blood of other animals, with special physiology, trophic function.Camel
Albumin in blood not only apparently higher than other animals, and with abnormal physiologically active high.Two-humped camel serum proteins are total to
There are 5 components such as albumin, α 1- globulin, α 2- globulin, betaglobulin and gamma globulin.The protein of camel serum is total
In amount, albumin content is up to 73.20%, hence it is evident that higher than the albumin of blood in the mammals such as sheep, ox, horse.Hunchbacked blood is more
Peptide has the physiological function such as antifatigue, anti-aging, strengthen immunity, anti-oxidant.
Described grape seed extract is can not synthesize in a kind of human body extracted from grape pip new and effective natural
Antioxidant substance, is anti-oxidant, the material that Scavenging ability is most strong of discovery in current nature, its antioxidation activity
It is 50 times, ascorbic 20 times of vitamin E, free radical unnecessary in human body can be effectively removed, with superpower anti-aging
With the effect of strengthen immunity；Meanwhile, with anti-oxidant, antiallergy, it is antifatigue, build up health, improve sub-health state, delay
The symptoms such as aging, improvement irritable, dizzy weak, failure of memory.
Described Tea Polyphenols has stronger antioxidation, and especially ester catechin EGCG, its reproducibility is even up to
100 times of the different bad hematic acid of L-；With bacteriostasis, such as there is inhibitory action to staphylococcus, Escherichia coli, hay bacillus；It is right
Anthocyanidin has protective effect in grape seed extract, can both play a part of natural pigment, can prevent food from fading again, also has
There are the formation and summation for suppressing nitrite.Therefore, the hunchbacked blood polypeptide milk piece that prepared by the present invention has stronger anti-oxidant
The effect such as effect, anti-aging and strengthen immunity.
The present invention has advantages below：（1）Use the hunchbacked blood polypeptide powder of small-molecular-weight, it is easier to which profit is absorbed by human body
With raising bioavilability；（2）The addition of grape seed extract and Tea Polyphenols, makes milk piece have anti-oxidant, anti-aging and increasing
The functions such as strong immunity；（3）Flavouring and flavouring agent are used, the mouthfeel of tablet has been improved, taste is micro- sweet, and with specific perfume (or spice)
Taste；（4）It is convenient to take, it is easy to carry and preserves, while has leisure and healthcare function；（5）By packaging technique, hunchbacked blood is improved
The stability and period of storage of polypeptide milk piece；（6）Preparation process is simple, low cost, easily operated, can meet industrialized production will
Ask, have broad application prospects.
During hunchbacked blood polypeptide and grape seed extract application prepared by the present invention, milk piece is not limited to, but with conventional
Preparation process, is used alone or prepares into different formulations from other compositions, such as powder, pill, capsule, tablet, micro-
Wafer, soft capsule, suppository, paste, tincture, electuary etc..
Specific embodiment
Embodiment 1
The preparation of hunchbacked blood polypeptide：2 kilograms of hunchbacked blood is taken, it is 7 to adjust pH value with ammoniacal liquor and acetic acid, and adding ethanol carries out alcohol precipitation, ethanol
Addition be hunchbacked blood:Ethanol mass ratio=1:5, stir 1 hour, 3 hours are stood, it is small with 2000 revs/min of centrifugation 2
When, water is added in precipitation, its final weight concentration is 10% solution, and it is 7 to be adjusted to pH value with ammoniacal liquor and acetic acid, adds silk
Serine protease, the addition of enzyme is enzyme:Hunchbacked blood mass ratio=1:50, digested 36 hours at a temperature of 30 DEG C, concentration, then freeze
It is dried to obtain hunchbacked blood polypeptide.
The preparation of grape seed extract：2 kilograms of grape pip is taken, grape pip powder is first broken to 20 mesh, add water, the addition of water
It is water to measure:Grape pip mass ratio=1:20, broken wall is sheared, 70 μm are less than to grape pip particle, ethanol solution is added, solution
Addition is solution:Grape pip mass ratio=1:30, to be extracted 36 hours at a temperature of 30 DEG C, filtering, concentration, spray drying is obtained
Grape seed extract.
It is prepared by hunchbacked blood polypeptide milk piece：
A）Sterilizing：Respectively by hunchbacked blood polypeptide powder, milk powder, grape seed extract, Tea Polyphenols, filler, binder, flavouring, perfume (or spice)
Taste agent, lubricant, coating powder utilize Co60 radiation sterilization；
B）Premix：According to parts by weight, the sterilized hunchbacked g of blood polypeptide powder 200 is weighed respectively, the g of milk powder 200, grape pip is extracted
The g of thing 50, Tea Polyphenols 50g, the g of microcrystalline cellulose 40, the g of sorbierite 80, the g of acesulfame potassium 5, the g of xylitol 5, magnesium stearate 6 g are red
The g of color coating powder 5, by hunchbacked blood polypeptide powder, milk powder, grape seed extract, Tea Polyphenols, microcrystalline cellulose, sorbierite, acesulfame potassium and
Xylitol crosses 80 mesh sieves, is well mixed；
C）Granulation：The g of polyethylene glycol 30 is weighed, 0.5% Aqueous Solutions of Polyethylene Glycol is configured to, is placed in ultrasound bath, ultrasound
It is stand-by to the uniform solution of water white transparency；To well mixed hunchbacked blood polypeptide, milk powder, grape seed extract, Tea Polyphenols, crystallite
Cellulose, sorbierite, acesulfame potassium, xylose spray the binder that oneself prepares, and adjust humidity of materials（3%）, held into material
Group, gently pressure is untill dissipating, material to be crossed into 30 eye mesh screens to finger, is dried, and drying temperature is 45 DEG C；
D）Whole grain：The material of caking is opened in stranding, is allowed to be dispersed into uniform particle, and sieving whole grain was 25 mesh, was dried, pellet moisture
Control is 2%；
E）Compressing tablet：The g of lemon extract 1 is weighed, the 1% lemon extract aqueous solution is configured to, is placed in ultrasound bath, ultrasound is
It is even, it is stand-by；The g of magnesium stearate 6 and the flavouring agent for preparing are added separately to whole grain material, are well mixed, then compressing tablet, compressing tablet
Piece weight be 0.8 g circular slice, thin piece；
F）It is coated：Under stirring, coating powder is configured to 5% coating solution with 60% alcohol 95 g, is advisable with not luming, must
100 mesh sieves can be crossed when wanting twice, be can be used after liquid is uniform.Plain piece temperature is heated to 40 DEG C, coating solution is sprayed into, until
Reach unilateral uniform color consistent, stop-spraying coating solution takes out tablet, and 50 DEG C of dryings obtain hunchbacked blood polypeptide milk piece.
The quality examination of hunchbacked blood polypeptide milk piece：
1st, measurement of water-content coefficient
It is measured using tablet fast tester for water content.If extracting test sample dry plate, it is placed in fast tester for water content, determines
Milk piece moisture content.Specific formula for calculation is as follows：
Milk piece moisture content（%）It is the percentage that total tablet quality is accounted for contained humidity quality in milk piece.
2nd, appearance character
Extract 100, sample, be laid on blank sheet of paper, be placed under 75 w light sources at 60 cm, at the cm of tablet 30 with the naked eye
Observation 30 seconds.It is unilateral to answer complete bright and clean；Uniform color, writing is clear；Variegated point（0.15~0.18 mm）＜ 5%；Pitted skin ＜ 5%；
Traditional Chinese medicine powder tailpiece（In addition to indivedual）＜ 10%, and must not have serious piebald and special foreign bodies；Coating tablet has lopsided person≤0.3%.
3rd, hardness
It is measured using tablet hardness meter.Tablet is vertically fixed between two cross bars, movable cross bar therein by
Spring radially pressurizes to tablet in the horizontal direction, and when tablet is broken, the spring of movable cross bar stops pressurization.Instrument calibration scale
Upper indicated pressure is hardness.6 are surveyed, is averaged.
4th, friability
It is measured using tablet friability somascope.If piece weight takes dry plate for 0.65 g or following persons, its gross weight is set to be about 6.5
g；Piece is great to take 10 in 0.65 g person.The powder for coming off is blown away with hair-dryer, precise weighing is placed in cylinder, rotate 100
It is secondary.Take out, powder, precise weighing are removed with method, less loss weight must not cross 1%, and must not detect fracture, cracking and the piece crushed.
This experiment is normally only made 1 time.During such as less loss weight more than 1%, should recheck 2 times, the average less loss weight of 3 times must not cross 1%, not
Fracture, cracking and the piece crushed must be detected.
When shape or size such as test sample make tablet form irregular rolling within the barrel, the base of cylinder is can adjust,
Make and desktop into about 10oAngle, tablet is no longer assembled during experiment, can smoothly fall.
Be should be noted that to hygroscopic preparation, during operation prevents moisture absorption（Generally control relative humidity is less than 40%）.
Table 1 is the quality examination of hunchbacked blood polypeptide milk piece prepared by the embodiment of the present invention 1
The quality examination of the hunchbacked blood polypeptide milk piece that table 2 is conventionally prepared
Embodiment 2
The preparation of hunchbacked blood polypeptide：5 kilograms of hunchbacked blood is taken, it is 8 to adjust pH value with ammoniacal liquor, adds ethanol to carry out alcohol precipitation, the addition of ethanol
It is hunchbacked blood:Ethanol mass ratio=1:20, stir 2 hours, 4 hours are stood, with 5000 revs/min of centrifugation 3 hours, precipitation
Middle addition water, its final weight concentration is 20% solution, and it is 8 to be adjusted to pH value with ammoniacal liquor, adds metalloproteinases, enzyme
Addition is enzyme:Hunchbacked blood mass ratio=1:200, digested 24 hours at a temperature of 60 DEG C, concentration, then be spray-dried that to obtain hunchbacked blood more
Peptide.
The preparation of grape seed extract：5 kilograms of grape pip is taken, grape pip powder is first broken to 40 mesh, add water, the addition of water
It is water to measure:Grape pip mass ratio=1:40, homogeneous broken wall is less than 50 μm to grape pip particle, adds ethanol solution, solution
Addition is solution:Grape pip mass ratio=1:60, to be extracted 20 hours at a temperature of 50 DEG C, filtering, concentration, freeze-drying is obtained
Grape seed extract.
Hunchbacked blood polypeptide method for preparing milk tablets：
A）Sterilizing：Respectively by hunchbacked blood polypeptide powder, milk powder, grape seed extract, Tea Polyphenols, filler, binder, flavouring, perfume (or spice)
Taste agent, lubricant, coating powder utilize microwave sterilization；
B）Premix：According to parts by weight, the sterilized hunchbacked g of blood polypeptide powder 400 is weighed respectively, the g of milk powder 600, grape pip is extracted
The g of thing 200, Tea Polyphenols 100g, the g of lactose 150, the g of starch 120, the g of Sucralose 20, the g of citric acid 20, the g of talcum powder 20 are blue
The g of color coating powder 20, by hunchbacked blood polypeptide powder, milk powder, grape seed extract, Tea Polyphenols, lactose, starch, Sucralose and citric acid
100 mesh sieves are crossed, is well mixed；
C）Granulation：The g of methylcellulose 100 is weighed, 1% methylcellulose ethanol solution is configured to, is placed in ultrasound bath,
Ultrasound is stand-by to the uniform solution of water white transparency；To well mixed hunchbacked blood polypeptide, milk powder, grape seed extract, Tea Polyphenols,
Lactose, starch, Sucralose and citric acid spray the binder that oneself prepares, and adjust humidity of materials（5%）, held into material
Group, gently pressure is untill dissipating, material to be crossed into 25 eye mesh screens to finger, is dried, and drying temperature is 60 DEG C；
D）Whole grain：The material of caking is opened in stranding, is allowed to be dispersed into uniform particle, and sieving whole grain was 20 mesh, was dried, pellet moisture
Control is 3%；
E）Compressing tablet：The g of hawthorn essence 5 is weighed, 10% hawthorn essence ethanol solution is configured to, is placed in ultrasound bath, ultrasound
Uniformly, it is stand-by；The g of talcum powder 10 and the flavouring agent for preparing are added separately to whole grain material, are well mixed, then compressing tablet, compressing tablet
Piece weight be 2.0 g rhombus slice, thin piece；
F）It is coated：Under stirring, blue coating powder is configured to 10% coating solution with the g of 80% ethanol 180, not lump
It is advisable, can crosses 100 mesh sieves twice if necessary, is can be used after liquid is uniform.Plain piece temperature is heated to 50 DEG C, is sprayed into and is coated
Liquid, until reaching, unilateral uniform color is consistent, stop-spraying coating solution takes out tablet, and 30 DEG C of dryings obtain hunchbacked blood polypeptide milk piece.
The quality examination result of hunchbacked blood polypeptide milk piece is same as Example 1.
Embodiment 3
The preparation of hunchbacked blood polypeptide：10 kilograms of hunchbacked blood is taken, it is 5 to adjust pH value with hydrochloric acid solution, and adding ethanol carries out alcohol precipitation, ethanol
Addition is hunchbacked blood:Ethanol mass ratio=1:40, stir 3 hours, 3 hours are stood, it is small with 7000 revs/min of centrifugation 4
When, water is added in precipitation, its final weight concentration is 30% solution, and it is 4.5 to be adjusted to pH value with hydrochloric acid solution, adds mercapto
Base protease and carboxyl protease（Mass ratio is 1:1）, the addition of enzyme is enzyme:Hunchbacked blood mass ratio=1:500, in 50 DEG C of temperature
Lower enzymolysis 12 hours, concentration, then freeze-drying obtains hunchbacked blood polypeptide.
The preparation of grape seed extract：Take 10 kilograms of grape pip, grape pip powder be first broken to 60 mesh, add water, water plus
Enter amount for water:Grape pip mass ratio=1:80, broken wall is sheared, 30 μm are less than to grape pip particle, add ethanol and acetic acid second
Ester solution（Volume ratio is 2:1）, the addition of solution is solution:Grape pip mass ratio=1:90,15 are extracted at a temperature of 40 DEG C small
When, filtering, concentration, spray drying obtains grape seed extract.
Hunchbacked blood polypeptide method for preparing milk tablets：
A）Sterilizing：Respectively by hunchbacked blood polypeptide powder, milk powder, grape seed extract, Tea Polyphenols, filler, binder, flavouring, perfume (or spice)
Taste agent, lubricant, coating powder are sterilized using ultraviolet irradiation；
B）Premix：According to parts by weight, the sterilized hunchbacked g of blood polypeptide powder 700 is weighed respectively, the g of milk powder 500, grape pip is extracted
The g of thing 400, Tea Polyphenols 500g, the g of mannitol 300, the g of hydroxypropyl cellulose 200, the g of sucrose 40, the g of maltitol 60, micro mist silicon
The g of glue 40, the g of pink colour coating powder 40, by hunchbacked blood polypeptide powder, milk powder, grape seed extract, Tea Polyphenols, mannitol, hydroxy propyl cellulose
Element, sucrose and maltitol cross 120 mesh sieves, are well mixed；
C）Granulation：The g of polyvinylpyrrolidone 150 is weighed, 5% polyvinylpyrrolidone ethanol solution is configured to, ultrasound is placed in
In ripple water-bath, ultrasound is stand-by to the uniform solution of water white transparency；Extracted to well mixed hunchbacked blood polypeptide, milk powder, grape pip
Thing, Tea Polyphenols, mannitol, hydroxypropyl cellulose, sucrose and maltitol spray the binder that oneself prepares, and adjust humidity of materials
（6%）, agglomerating to material holding, gently pressure is untill dissipating, material to be crossed into 18 eye mesh screens to finger, and dry, drying temperature is 70 DEG C；
D）Whole grain：The material of caking is opened in stranding, is allowed to be dispersed into uniform particle, and sieving whole grain was 16 mesh, was dried, pellet moisture
Control is 5%；
E）Compressing tablet：The g of orange flavor 40 is weighed, the 50% orange flavor aqueous solution is configured to, is placed in ultrasound bath, ultrasound is
It is even, it is stand-by；The g of superfine silica gel powder 40 and the flavouring agent for preparing are added separately to whole grain material, are well mixed, then compressing tablet, compressing tablet
Piece weight be 4.0 g oval slice, thin piece；
F）It is coated：Under stirring, pink colour coating powder is configured to 40% coating solution with the g of 95% ethanol 60, is not lump
Preferably, 100 mesh sieves can be crossed twice if necessary, is can be used after liquid is uniform.Plain piece temperature is heated to 30 DEG C, is sprayed into and is coated
Liquid, until reaching, unilateral uniform color is consistent, stop-spraying coating solution takes out tablet, and 60 DEG C of dryings obtain hunchbacked blood polypeptide milk piece.
The quality examination result of hunchbacked blood polypeptide milk piece is same as Example 1.
Embodiment 4
The preparation of hunchbacked blood polypeptide：50 kilograms of hunchbacked blood is taken, it is 3 to adjust pH value with hydrochloric acid solution, and adding ethanol carries out alcohol precipitation, ethanol
Addition is hunchbacked blood:Ethanol mass ratio=1:60, stir 5 hours, 5 hours are stood, it is small with 15000 revs/min of centrifugation 5
When, water is added in precipitation, its final weight concentration is 40% solution, and it is 2.5 to be adjusted to pH value with hydrochloric acid, adds carboxyl egg
White enzyme, the addition of enzyme is enzyme:Hunchbacked blood mass ratio=1:1500, digested 8 hours at a temperature of 45 DEG C, concentration, then freeze-drying is obtained
To hunchbacked blood polypeptide.
The preparation of grape seed extract：Take 50 kilograms of grape pip, grape pip powder be first broken to 80 mesh, add water, water plus
Enter amount for water:Grape pip mass ratio=1:150, homogeneous broken wall is less than 10 μm to grape pip particle, adds acetate solution,
The addition of solution is solution:Grape pip mass ratio=1:120, to be extracted 8 hours at a temperature of 35 DEG C, filtering, concentration, freezing is dry
It is dry to obtain grape seed extract.
Hunchbacked blood polypeptide method for preparing milk tablets：
A）Sterilizing：Respectively by hunchbacked blood polypeptide powder, milk powder, grape seed extract, Tea Polyphenols, filler, binder, flavouring, perfume (or spice)
Taste agent, lubricant, coating powder are gasified using thimerosal and sterilized；
B）Premix：According to parts by weight, the sterilized hunchbacked g of blood polypeptide powder 900 is weighed respectively, the g of milk powder 800, grape pip is extracted
The g of thing 600, Tea Polyphenols 400g, the g of superfine silica gel powder 400, the g of fructose 400, the g of Aspartame 100, the g of neotame 50, dodecyl sulphur
The g of sour magnesium 150, the g of green coating powder 200, by hunchbacked blood polypeptide powder, milk powder, grape seed extract, Tea Polyphenols, superfine silica gel powder, fruit
Sugar, Aspartame and neotame cross 70 mesh sieves, are well mixed；
C）Granulation：The g of hydroxypropyl cellulose 300 is weighed, 10% hydroxypropyl cellulose aqueous solution is configured to, ultrasound bath is placed in
In, ultrasound is stand-by to the uniform solution of water white transparency；It is many to well mixed hunchbacked blood polypeptide, milk powder, grape seed extract, tea
Phenol, superfine silica gel powder, fructose, Aspartame and neotame spray the binder that oneself prepares, and adjust humidity of materials（4%）, to material hand
Hold agglomerating, gently pressure is untill dissipating, material to be crossed into 16 eye mesh screens to finger, is dried, and drying temperature is 90 DEG C；
D）Whole grain：The material of caking is opened in stranding, is allowed to be dispersed into uniform particle, and sieving whole grain was 14 mesh, was dried, pellet moisture
Control is 4%；
E）Compressing tablet：The g of butter essence 150, is configured to 30% orange flavor ethanol solution, is placed in ultrasound bath, and ultrasound is
It is even, it is stand-by；The g of Stepanol MG 150 and the flavouring agent for preparing are added separately to whole grain material, are well mixed, then pressed
Piece, the piece weight of compressing tablet is the olive shape slice, thin piece of 3.0 g；
F）It is coated：Under stirring, green coating powder is configured to 20% coating solution with the g of 85% ethanol 800, not lump
It is advisable, can crosses 100 mesh sieves twice if necessary, is can be used after liquid is uniform.Plain piece temperature is heated to 60 DEG C, is sprayed into and is coated
Liquid, until reaching, unilateral uniform color is consistent, stop-spraying coating solution takes out tablet, and 80 DEG C of dryings obtain hunchbacked blood polypeptide milk piece.
The quality examination result of hunchbacked blood polypeptide milk piece is same as Example 1.
The composition that the present invention is prepared in the specific embodiment of hunchbacked blood polypeptide milk piece is shown in Table 3.
The hunchbacked blood polypeptide milk piece proportion of composing of table 3
。
Claims (10)
1. a kind of hunchbacked blood polypeptide milk piece, it is characterised in that the mass fraction shared by component that the milk piece is included and each component is：
50 ~ 1000 parts of hunchbacked blood polypeptide powder, 50 ~ 1000 parts of milk powder, 50 ~ 1000 parts of grape seed extract, 50 ~ 1000 parts of Tea Polyphenols, filling
50 ~ 1000 parts of agent, 1 ~ 500 part of binder, 1 ~ 500 part of flavouring, 1 ~ 500 part of flavouring agent, 1 ~ 500 part of lubricant, coating powder 1 ~
500 parts；The preparation method of the grape seed extract：With grape pip as raw material, grape pip powder is first broken to 10 ~ 200 mesh, added
Water, shearing or homogeneous broken wall, 70 μm are less than to grape pip particle, add ethanol, ethyl acetate or the mixed solution of the two,
Extracted 0.1~36 hour at a temperature of 20~90 DEG C, filtering, concentration, spray drying or freeze-drying obtain grape seed extract.
2. camel blood polypeptide milk piece as claimed in claim 1, it is characterised in that the addition of the water is water and grape pip quality
Than being 1:1~200；The addition of the ethanol, ethyl acetate or mixed solution is ethanol, ethyl acetate or mixed solution and Portugal
Grape seed mass ratio is 1:1~300.
3. camel blood polypeptide milk piece as claimed in claim 1, it is characterised in that the preparation method of the hunchbacked blood polypeptide：It is with hunchbacked blood
Raw material, it is 2 ~ 10 to adjust pH value with ammoniacal liquor, acetic acid, hydrochloric acid or sodium hydroxide solution, adds ethanol to carry out alcohol precipitation, and stirring 0.5 ~ 6 is small
When, 1 ~ 48 hour is stood, add water to make the matter of solution with 1000 ~ 20000 revs/min of centrifugation 0.1 ~ 6 hour, in precipitation
Amount concentration is 5% ~ 60%, and is adjusted to 1 ~ 12 with ammoniacal liquor, acetic acid, hydrochloric acid or sodium hydroxide solution pH value, adds proteolytic enzyme,
Digested 0.2~48 hour at 20~70 DEG C, concentration, then be spray-dried or freeze-drying obtains hunchbacked blood polypeptide.
4. camel blood polypeptide milk piece as claimed in claim 3, it is characterised in that the proteolytic enzyme be serine protease,
The mixture of one or more in thiol protease, metalloproteinases or carboxyl protease.
5. camel blood polypeptide milk piece as claimed in claim 3, it is characterised in that the addition of the ethanol is hunchbacked blood and ethanol
Mass ratio is 1:1~100；The addition of the proteolytic enzyme is enzyme and camel blood mass ratio is 1:5~3000.
6. camel blood polypeptide milk piece as claimed in claim 1, it is characterised in that the milk powder is whole milk powder, skimmed milk power and acid
Any one or several mixtures of milk milk powder；The filler is lactose, sucrose, glucose, fructose, mannitol, mountain
Any one in pears alcohol, xylitol, microcrystalline cellulose, starch, hydroxypropyl cellulose, superfine silica gel powder or several mixing
Thing；The binder be ethanol, water, 0.1% ~ 20% polyethylene glycol, 0.1% ~ 20% polyvinylpyrrolidone ethanol or the aqueous solution,
0.1% ~ 20% methylcellulose ethanol or the aqueous solution, 0.1% ~ 20% ethyl cellulose ethanol or the aqueous solution, 0.1% ~ 20% hydroxypropyl
In cellulosic ethanol or the aqueous solution, 0.1% ~ 20% sodium carboxymethylcellulose ethanol or the aqueous solution, dextrin, starch any one or
Several mixture of person；The flavouring is steviol glycoside, rebaudioside A, Aspartame, vitamin C, protein sugar, trichlorine sugarcane
Sugar, citric acid, lactic acid, malic acid, D-sorbite, mannitol, maltitol, hydroxyl isomaltulose, saccharin sodium, honey element, Ah
Power is sweet, any one or several mixtures of neotame, acesulfame potassium；The flavouring agent is Mint Essence, flavoring orange essence, cream
Essence, lemon extract, flavoring pineapple essence, mango essence, blackberry essence, blueberry flavor, strawberry essence, raspberry essence, cherry essence,
Grape essence, blackcurrant essence, orange flavor, grapefruit essence, flavoring apple essence, peach essence, pear essence, apricot essence, hawthorn essence,
Cocoanut flavour, small wheat essence, barley essence, lychee flavor, oat essence, corn essence, sorghum essence, buckwheat essence, beans are used
Essence any one or it is several；The lubricant is magnesium stearate, stearic acid, superfine silica gel powder, talcum powder, dodecyl sulphur
Any one in sour magnesium or several mixtures；The coating powder is colored coating powder.
7. the preparation method of camel blood polypeptide milk piece as claimed in claim 1, comprises the following steps：
1）Sterilizing：By preparation with raw material sterilized；
2）Premix：Sterilized 50 ~ 1000 parts of hunchbacked blood polypeptide powder, 50 ~ 1000 parts of milk powder, grape pip are weighed according to mass fraction to carry
Take 50 ~ 1000 parts of thing, 50 ~ 1000 parts of Tea Polyphenols, 50 ~ 1000 parts of filler, 1 ~ 500 part of binder, 1 ~ 500 part of flavouring, perfume
Taste agent is 1 ~ 500 part, 1 ~ 500 part of lubricant, 1 ~ 500 part of coating powder, and hunchbacked blood polypeptide powder, milk powder, grape seed extract, tea is more
Phenol, filler and flavouring cross 60 ~ 200 mesh sieves, well mixed to be made pre-mixture；
3）Granulation：Binder is made solution with ultrasonically treated, step 2 is uniformly sprayed onto）Made in prepared pre-mixture
Into material；Adjustment humidity of materials to moisture content be 0.2% ~ 20%, material is crossed into 5 ~ 60 eye mesh screens, dry, drying temperature be 25~
100℃；
4）Whole grain：The material of caking is opened in stranding, is allowed to be dispersed into uniform particle, and sieving whole grain was 5 ~ 60 mesh, was dried, particle water
Sub-control system is made whole grain material 1~10%；
5）Compressing tablet：Flavouring agent is weighed, flavouring agent ethanol or the aqueous solution is configured to, is placed in ultrasound bath, ultrasound is uniform；Will profit
Lubrication prescription and the flavouring agent for preparing are added separately to whole grain material, are well mixed, then compressing tablet；
6）It is coated：Under stirring, coating powder is configured to the coating solution that concentration is 1% ~ 50% with 50% ~ 95% ethanol；Will step
Rapid 5）The pelletizing temperature being made is heated to 30 ~ 70 DEG C, sprays into coating solution, until it is consistent to reach unilateral uniform color, then 25 ~
Hunchbacked blood polypeptide milk piece is obtained after 100 DEG C of dryings.
8. preparation method as claimed in claim 7, it is characterised in that step 1）Described in sterilizing methods using Co60 radiate
Sterilizing, ultraviolet irradiation sterilizing, thimerosal gasification sterilizing, microwave sterilization, ethanol immersion sterilizing or spray drying sterilizing.
9. preparation method as claimed in claim 7, it is characterised in that the binder solvent is ethanol, water or two kinds of solution groups
Close.
10. preparation method as claimed in claim 7, it is characterised in that the hunchbacked blood polypeptide milk piece is circular piece, ellipse, ring
Shape, triangle or rhombus.
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| CN113797320A (en) * | 2021-11-01 | 2021-12-17 | 杭州佰倍优生物科技有限公司 | Polypeptide composition for improving anemia symptoms and preparation method thereof |
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