CN106697344B - A kind of micro filling spray head of ultrasonic vibration formula powder - Google Patents

A kind of micro filling spray head of ultrasonic vibration formula powder Download PDF

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Publication number
CN106697344B
CN106697344B CN201710038576.0A CN201710038576A CN106697344B CN 106697344 B CN106697344 B CN 106697344B CN 201710038576 A CN201710038576 A CN 201710038576A CN 106697344 B CN106697344 B CN 106697344B
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Prior art keywords
filling
runner
powder
ultrasonic vibration
cylindrical flow
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CN106697344A (en
Inventor
李宗奇
陈岚
陈东浩
黄鹏
孙梅生
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Hangzhou Changxi Pharmaceutical Co Ltd
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Hangzhou Changxi Pharmaceutical Co Ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/04Methods of, or means for, filling the material into the containers or receptacles
    • B65B1/08Methods of, or means for, filling the material into the containers or receptacles by vibratory feeders
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/30Devices or methods for controlling or determining the quantity or quality or the material fed or filled

Abstract

The invention discloses a kind of micro filling spray heads of ultrasonic vibration formula powder, including filling runner and the ultrasonic vibration source being mounted on filling runner, the cylindrical flow internal diameter of filling runner is designed as 6~10 millimeters, cone cavity lower end exit inside diameter is designed as 0.6~1.5 millimeter, the semi-cone angle of the cone cavity is designed as 6~20 °, and the total height of cylindrical flow and cone cavity is greater than 10 millimeters of cylindrical flow height or more.Key parameter and specific parameter area in the perfect entire runner design of runner of the invention, are more advantageous to the micro filling control of medicament powder.And, pass through the research to runner selection, so that the flow velocity of powder is more stable in runner, so that micro filling control is more accurate, effective, especially suitable for 20 milligrams every dose of < such as realization milligram ammonia powder conveyance in the production process of respiratory tract dry powder induction type medicament (as capsule, vesica) and filling accurate quantification.

Description

A kind of micro filling spray head of ultrasonic vibration formula powder
Technical field
The present invention relates to powder filling equipment, more specifically to a kind of micro filling spray head of ultrasonic vibration formula powder.
Background technique
In pharmaceuticals industry, powder body material is related to each of medicament research and development and production as raw material, intermediate, final products A link.For improve drug biological effect and human body to the drug absorption of poorly water-soluble, powder granule used in pharmaceutical preparation Partial size is usually as low as micron or nanoscale.But this kind of fine materials can show excessively poor mobility, give medicament research and development and life Production causes very big operating technology problem and wastage of material.Wherein, respiratory tract dry powder induction type medicament is as treatment asthma, slow Property the pulmonary diseases such as obstructive pneumonia effective means, research and development and production start to be highly valued at home.Dry powder sucking The production of agent is supervised by stringent pharmacy and manufacturer's standard, wherein most challenging is between homogeneity Foradil Aerolizer formoterol fumarate agent Control.Therefore, the filling of medicament powder becomes an important link for influencing product quality.The accuracy of filling process decides Homogeneity between drug agent.Its high efficiency can solve product high production cost in process of production, and the period is long, and wastage of material is tight The problems such as weight, reduces the energy, the waste of the resources such as material and manpower.For such technical need, people is studied in last century end Member begins to focus on the micro Canning Technique of powder in the application of designative species.
Currently, the micro Canning Technique of common powder is using pneumatics and volumetric method.Patent US4350049 is 1982 It describes in year and pneumatics and volumetric method is incorporated in the micro application in transit of powder.But method cannot provide successional powder Body conveying, powder stuffing and transport are alternately accomplished.It is difficult to produce micro- dosage medicament (< using the Canning Technique of volumetric method 20 milligrams);The weighing of filling powder is completed by pre-designed volume quantitative slot, and accuracy is by powder packing density of particle Real-time change influenced;Need to redesign replacement filling apparatus if you need to change filling dosage, this undoubtedly increase the time with Economic cost.And can be only done the filling of single powder or powder mixture, it just must be first by these for multicomponent pharmaceutical Component largely mixes, and then carries out again filling, will lead to so uneven by component between mixing bring agent.In addition, to viscosity Also it is easy to appear powder blockings when high powder carries out filling, lead to low dosage output or process stands idle.
Gravimetric method is the micro filling solution of another powder.Powder pass through under gravity nozzle discharging into Enter target position.However, medicament production in superfine powder due to its mobility it is bad, can not achieve free flow under the effect of gravity It is dynamic, it can not guarantee the consistency of each filling dosage, influence filling accuracy or even product quality.Open source literature J Biomol It is described in Screen, 10 (2005) p524-531 to realize that accurate gravimetric method is filling, bulking system has added instant matter Measure the weight balancing system in iterative feedback circuit.The system feeds back instantaneous weight by balance to control spray head valve to open and close Close powder flowing discharging.Filling accuracy is improved in this way, but is also brought process time-consuming simultaneously and be difficult to be suitable for extensive raw The defect of producing line.
Root the latest researches have found that, by vibrational excitation and control the micro Canning Technique of powder can effectively solve volumetric method With the existing applied defect of gravimetric method.It is right during transporting using capillary or the realization of miniature funnel are micro and is filling Transporting channel application is facilitated between destruction high viscosity powder agglomeration and particle to encircle power by the vibration that pulse signal controls, and causes powder It flows freely.Patent GB2472817 describe vibration powder body material it is micro it is filling on application.
The delivery pipe of three kinds of different structures is disclosed in patent GB2472817, as shown in Fig. 1 a~Fig. 1 c, and gives phase Answer parameter: minimum 5 millimeters in the horizontal direction of the internal diameter D (disregarding pipe thickness) of upper vertical parts;Outlet aperture d is in water Square it is up to 200 microns to 3 millimeters upwards;The angle [alpha] of lower part cone inclined-plane and vertical direction is at 5 degree to 45 degree (see Fig. 3).
Water is also described in patent GB2472817 as medium and propagates ultrasonic activation, therefore Vibration propagation medium Influence of the property to powder flowing is also a key factor in need of consideration.
But since above-mentioned patent and open source literature only exist in a primary research for the micro control technology of powder Stage, disclosed above-mentioned parameter are also only a general, wide in range ranges, are only suitable for laboratory test, and have not been able into one Walk in-depth study.Since the physical property of various powder itself is different, with the study found that above-mentioned design parameter is not only not complete enough It is whole, and can not really and well realize various powder, especially such as this kind of fine particle of medicament and poor fluidity, easily The micro filling control of the high viscosity powder of agglomeration.With the production of respiratory tract dry powder induction type medicament (such as capsule, vesica) Demand constantly increases, and there is an urgent need to the micro control technologies to pharmacy powder further to be furtherd investigate, micro to realize Change powder conveyance and filling real accurate quantification.
Summary of the invention
For disadvantages mentioned above existing in the prior art, the object of the present invention is to provide a kind of ultrasonic vibration formula powder is micro Filling spray head realizes the micro filling control of medicament powder by ultrasonic vibration.
To achieve the above object, the present invention adopts the following technical scheme:
The micro filling spray head of ultrasonic vibration formula powder, including filling runner and the ultrasonic vibration being mounted on filling runner Source, filling runner include cylindrical flow and cone cavity, and cylindrical flow is connected to cone cavity upper end, and cone Runner upper-end inner diameter is identical as cylindrical flow internal diameter and is greater than cone cavity lower end exit inside diameter, the cylindrical flow Internal diameter is designed as 6~10 millimeters, and the cone cavity lower end exit inside diameter is designed as 0.6~1.5 millimeter, the circular cone The semi-cone angle of shape runner is designed as 6~20 °, and the total height of cylindrical flow and cone cavity is greater than cylindrical flow height 10 Millimeter or more.
The inner wall surface of the cylindrical flow lower end and cone cavity upper end connectivity part is a continuous cambered surface, should The radius of curvature of cambered surface is greater than 1.5 times of cylindrical flow internal diameter.
The material production that the filling runner is damped using light weight, low vibration.
The filling runner is made of Pyrex.
The ultrasonic vibration source is mounted on filling runner by fixing piece, and fixing piece is cylinder-shaped fixing piece, to It is set in filling runner lower part, the ultrasonic vibration source is attached at cylinder-shaped fixing piece lower surface.
The ultrasonic vibration source is circular ring shape piezoelectric ceramics inverting element.
In the above-mentioned technical solutions, the micro filling spray head of ultrasonic vibration formula powder of the invention has several advantages that
1, key parameter and specific parameter area in perfect entire runner, are more advantageous to fine particle and mobility Difference is easily agglomerated, the micro filling control of highly viscous medicament powder.
2, the selection requirements to runner material are proposed, so that runner is high-efficient to Vibration propagation.
3, Pyrex are proposed as preferable runner processing material.
4, a kind of filling nozzle structure of medicament powder using ultrasonic vibration source is proposed.
Detailed description of the invention
Fig. 1 a~Fig. 1 c is the structural schematic diagram of three kinds of delivery pipes of the prior art respectively;
Fig. 2 is the decomposition diagram of the micro filling spray head of ultrasonic vibration formula powder of the invention;
Fig. 3 is the scheme of installation of the micro filling spray head of ultrasonic vibration formula powder of the invention;
Fig. 4 is a kind of structural schematic diagram of embodiment of filling runner of the invention;
Fig. 5 is the structural schematic diagram of another embodiment of filling runner of the invention;
Fig. 6 is the scheme of installation of filling runner and ultrasonic vibration source of the invention.
Specific embodiment
Technical solution of the present invention is further illustrated with reference to the accompanying drawings and examples.
The micro filling spray head of ultrasonic vibration formula powder of the invention is as shown in Figure 2 to 3, and main includes the spray head of circular tube shaped Shell 10, the filling runner 11 being fixedly arranged in nozzle housing 10 and ultrasonic vibration source 14, filling runner 11 can be used such as Fig. 4, Fig. 5 Two kinds of different forms, Fig. 4 are tube body form, and Fig. 5 is cavity form, certainly can also be using other forms.Also, the present invention 11 structure of filling runner be with patent GB2472817 something in common, equally also include cylindrical flow 1 and cone cavity 2, cylindrical flow 1 is connected to 2 upper end of cone cavity, and 2 upper-end inner diameter of cone cavity is identical as 1 internal diameter of cylindrical flow And it is greater than 2 bottom diameter of cone cavity.
The difference is that the present invention calculates repeatedly by further in-depth study and repeatedly, tests discovery, the filling The key parameter for filling runner 11 should include 1 internal diameter D of cylindrical flow, 2 lower end exit inside diameter D of cone cavityo, cone stream The semi-cone angle α in road 2 and the overall height H of cylindrical flow 1 and cone cavity 2, aforementioned four parameter is indispensable, each parameter Specific value range is as follows: the 1 internal diameter D of cylindrical flow is designed as 6~10 millimeters, 2 lower end of cone cavity Exit inside diameter DoIt is designed as 0.6~1.5 millimeter, the semi-cone angle α of the cone cavity 2 is designed as 6~20 °, cylindrical flow The overall height H of road and cone cavity should be greater than 10 millimeters of cylindrical flow height or more, with meet little particle and poor fluidity, It easily agglomerates, the micro filling control of highly viscous medicament powder.
It should be noted that parameter DoValue range be common by powder granule physical property and external vibration parameter It determines.If the powder being filled in runner under gravitational field can be by the minimum-value aperture of the spontaneous outflow of round hole of bottom end Dc, as the aperture D processedo≥Dc, gone after inserting certain altitude after being blocked the hole with object to filling powder in runner Fall to get lodged in the object of orifice position, runner inner powder cognition flows downward out at this time;Conversely, as the aperture D processedo< Dc, repeat Operation above, powder is still in original place in runner after removing tamper, will not flow downward out.
Under effect of vibration, being somebody's turn to do " critical value " becomes Dc,v, define method and DcIt is similar.Dc,vLess than Dc, therefore in order to make Powder only flows out under effect of vibration and static under state without friction, therefore reasonably processes aperture selection in the present invention and should abide by It follows with lower inequality:
D(c,v)<Do<Dc
Tested final determining, DoIt is designed as 0.6~1.5 millimeter.
And the determination of semi-cone angle α is increasingly complex, when astringent runner constitutes a conical lower portion, this cone angle is to internal powder Stream is dynamic important influence.For powder in runner other than sliding between particle occurs, particle can also be sliding along runner wall surface It is dynamic.When powder reaches internal yield boundary, powder granule occurs to slide between particle;When reaching wall surface surrender boundary, particle Betide the opposite sliding between wall surface.Maximum tapered runner half-angle α max needed for powder flowing occurs for angle of wall friction w is related. So should be less than " critical value " α max for the value for enabling powder freely to flow out astringent runner half-angle.It is tested final true Fixed, α is designed as 6~20 °.
And justify that 1 internal diameter D of straight pipe type runner is bigger, and powder flowing resistance is smaller, mass flow is more stable.But D increase can add Big runner overall dimensions, are unfavorable for the Miniaturization Design of entire bulking system.It is finally determined through testing, D is designed as 6~10 millis Rice.
Since the mobility of pharmacy pulvis is usually poor, during being flowed from cylindrical flow to cone cavity, Easily assemble in junction, influences the flowing of subsequent powder, therefore the present invention has also been devised with flowering structure: in the circle The inner wall surface of 1 lower end of pipe running system and 2 upper end connectivity part of cone cavity is a continuous cambered surface, the radius of curvature of the cambered surface R is bigger, and powder flowing resistance is smaller, and mass flow is more stable, therefore determines by the way that experiment is final, by the radius of curvature of the cambered surface R is designed as the cylindrical flow internal diameter greater than 1.5 times.By above-mentioned cambered surface transition, pharmacy pulvis here poly- can be avoided Collect phenomenon, guarantees the homogeneity of the flow velocity of pharmacy pulvis, be more conducive to micro accurate filling control.
The material selection of above-mentioned filling runner 11 need to follow the following: light weight, low vibration damping.
Therefore, as one embodiment, the production of the materials such as Pyrex is can be used in the filling runner 11.
Incorporated by reference to shown in Fig. 2,3,6, the ultrasonic vibration source 14 is fixed on filling runner 11 by fixing piece 13.Make For one embodiment, fixing piece 13 is cylinder-shaped fixing piece, and to be set in filling runner lower part, the ultrasonic vibration source is Circular ring shape piezoelectric ceramics inverting element is attached at cylinder-shaped fixing piece lower surface, is mounted on filling runner 11 with realizing.When So, the fixing piece and piezoelectric ceramics inverting element of other shapes and structure can also be used.The frequency of piezoelectric ceramics inverting element Within the scope of 30000 hertz to 50000 hertz, the electrode polarization direction of piezoelectric ceramics inverting element is to be perpendicularly oriented to water passage surface Direction, this side up, piezoelectric ceramics inverting element generates under 30000 hertz to the pulse voltage of 50000 hertz frequencies High-frequency vibration.In this way, controlling the ultrasonic vibration and stopping of piezoelectric ceramics inverting element, by pulse voltage signal to realize control Filling (material is fallen) of filling spray head and stop filling.
In addition, 10 upper and lower ends of nozzle housing are additionally provided with dismountable upper and lower cover 15,16, by unscrewing upper cover 15, powder charging can be carried out in runner;After unscrewing lower cover 16, it can carry out filling.
Filling embodiment is carried out to various medicaments powder using the micro filling spray head of ultrasonic vibration formula powder of the invention It is as follows:
It is shown in above-described embodiment applied to 200 microns to the medicament powder in 30 micron particles particle size ranges, runner Parameter has different between medicament powder discharge rate in the runner of ultrasonic action from discharging precision (relative standard deviation agent) It influences.In selected runner parameter area, the medicament powder that milligram ammonia (< 100 milli Grams Per Second) may be implemented is filling and be less than Error between 5% agent, the minimum error requirement of error in embodiment much smaller than homogeneity between industry agent.
In conclusion using disclosed in the micro filling spray head of ultrasonic vibration formula powder and patent GB2472817 of the invention Delivery pipe compare, have the advantages that following multiple:
1, further further investigation, improves runner design, increase cylindrical flow and cone cavity internal diameter, Highly, semi-cone angle, the parameters such as radius of connectivity part cambered surface, so that entire flow passage structure parameter is more perfect, and by repeatedly anti- Retrial is tested and calculating obtains each parameter more specifically numberical range, to be more advantageous to fine particle and poor fluidity, easily It agglomerates, the micro filling control of highly viscous medicament powder.
2, the selection requirements to runner material are proposed so that runner can be more advantageous to it is micro it is filling it is accurate, Effectively control.
3, Pyrex are proposed as preferable runner processing material.
4, the volume markings for being 1 milliliter just like precision can be marked in glass channel outer surface, the powder in convenient reading runner Expect surplus.
5, the micro filling spray head of ultrasonic vibration formula powder of the invention can be widely used in several grams every dose, diameter for number milli The micro- dosage medicament filling control of medicament of rice, especially suitable for 20 milligrams every dose of < of such as respiratory tract dry powder induction type medicament Milligram ammonia powder conveyance and filling accurate quantification are realized in the production process of (such as capsule, vesica), especially for tiny The high viscosity powder that grain (especially less than 10 microns) and poor fluidity easily agglomerate helps to improve product matter in medicament production Amount, reduces cost, reduces time and the complexity of pharmacy.Certainly, the present disclosure additionally applies for other classes in addition to medicament powder Like the micro filling control of powder of physical property.
8, using there are visibly different vibration source structures (piezoelectric energy-conversion element) and vibration source to assemble with GB patent Mode, a kind of split type ultrasonic vibration source 14 of brand-new design drive filling runner ultrasound to shake by the transmission of fixing piece It is dynamic, to reach the control mode of more preferably high-frequency vibration, so that micro filling design be made to come true.
Those of ordinary skill in the art it should be appreciated that more than embodiment be intended merely to illustrate the present invention, And be not used as limitation of the invention, as long as the change in spirit of the invention, to embodiment described above Change, modification will all be fallen within the scope of claims of the present invention.

Claims (3)

1. a kind of micro filling spray head of ultrasonic vibration formula powder, it is characterised in that: including filling runner and be mounted on filling runner On ultrasonic vibration source, filling runner includes cylindrical flow and cone cavity, and cylindrical flow is connected to cone cavity Upper end, and cone cavity upper-end inner diameter is identical as cylindrical flow internal diameter and is greater than cone cavity lower end exit inside diameter, institute The cylindrical flow internal diameter stated is designed as 6~10 millimeters, and the cone cavity lower end exit inside diameter is designed as 0.6~1.5 Millimeter, the semi-cone angle of the cone cavity are designed as 6~20 °, the total height and circle of cylindrical flow and cone cavity The difference of pipe running system height is at 10 millimeters or more;
The inner wall surface of the cylindrical flow lower end and cone cavity upper end connectivity part is a continuous cambered surface;Described The radius of curvature of cambered surface is greater than 1.5 times of cylindrical flow internal diameter;
The ultrasonic vibration source is mounted on filling runner by fixing piece, and fixing piece is cylinder-shaped fixing piece, to be arranged In filling runner lower part, the ultrasonic vibration source is attached at cylinder-shaped fixing piece lower surface, and the ultrasonic vibration source is circle Ring-shaped piezo ceramic inverting element.
2. the micro filling spray head of ultrasonic vibration formula powder as described in claim 1, it is characterised in that:
The material production that the filling runner is damped using light weight, low vibration.
3. the micro filling spray head of ultrasonic vibration formula powder as described in claim 1, it is characterised in that:
The filling runner is made of Pyrex.
CN201710038576.0A 2017-01-19 2017-01-19 A kind of micro filling spray head of ultrasonic vibration formula powder Active CN106697344B (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350049A (en) * 1979-11-09 1982-09-21 Boehringer Ingelheim Gmbh Device and process for drawing off very small quantities of powder
EP0282958A1 (en) * 1987-03-19 1988-09-21 Boehringer Ingelheim Zentrale Gmbh Process and device for dosing powders
WO2008003942A2 (en) * 2006-07-01 2008-01-10 The University Of Manchester Powder delivery apparatus
GB2472817A (en) * 2009-08-19 2011-02-23 Queen Mary & Westfield College Powder dispenser with permanently-open linear-taper nozzle operated by vibration
CN203497769U (en) * 2013-08-28 2014-03-26 厦门泰益新洁净科技有限公司 Supplying device of powdery materials
WO2014111718A1 (en) * 2013-01-17 2014-07-24 Varydose Limited Apparatus and method for dispensing powders
CN205738155U (en) * 2016-07-01 2016-11-30 河北工业大学 A kind of rotating micro powder filling device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350049A (en) * 1979-11-09 1982-09-21 Boehringer Ingelheim Gmbh Device and process for drawing off very small quantities of powder
EP0282958A1 (en) * 1987-03-19 1988-09-21 Boehringer Ingelheim Zentrale Gmbh Process and device for dosing powders
WO2008003942A2 (en) * 2006-07-01 2008-01-10 The University Of Manchester Powder delivery apparatus
GB2472817A (en) * 2009-08-19 2011-02-23 Queen Mary & Westfield College Powder dispenser with permanently-open linear-taper nozzle operated by vibration
WO2014111718A1 (en) * 2013-01-17 2014-07-24 Varydose Limited Apparatus and method for dispensing powders
CN203497769U (en) * 2013-08-28 2014-03-26 厦门泰益新洁净科技有限公司 Supplying device of powdery materials
CN205738155U (en) * 2016-07-01 2016-11-30 河北工业大学 A kind of rotating micro powder filling device

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