CN106691675A - Intravascular laser heating whole body thermal therapy instrument - Google Patents
Intravascular laser heating whole body thermal therapy instrument Download PDFInfo
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- CN106691675A CN106691675A CN201510444497.0A CN201510444497A CN106691675A CN 106691675 A CN106691675 A CN 106691675A CN 201510444497 A CN201510444497 A CN 201510444497A CN 106691675 A CN106691675 A CN 106691675A
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Abstract
The invention provides an intravascular laser heating whole body thermal therapy instrument. The instrument comprises an interventional catheter, a laser generator, a laser pulse width modulation system, a body temperature monitoring system and a computer control system. The interventional catheter comprises a catheter body, a metal target, a first thermistor, a second thermistor, a third thermistor, a laser optical fiber coupling terminal and a temperature measuring electrode terminal. The catheter body comprises a cannula, a laser optical fiber and a temperature measuring wire. By using the intravascular laser heating whole body thermal therapy instrument, the temperature of the whole body of a patient can be increased to the temperature treatment interval of 42.5+/-0.5 DEG C safely and easily, the interventional catheter can stay in the body of the patient in a short time, and the aim of repeated treatment is achieved.
Description
Technical field
The invention belongs to field of medical device, more particularly to a kind of Ink vessel transfusing LASER HEATING whole body thermal therapy instrument.
Background technology
In Greek, original meaning refers to " hyperpyrexia " or " overheat " to the etymology of thermotherapy (Hyperthermia), it
It is a class of physical treatment, with various thermals source as amboceptor, transfers heat to body, reaches therapeutic purposes
Therapy.
Tumor thermotherapy, refers to use physics method, biological tissue's heat temperature raising is killed cancer cell, is reached
The technology and method of therapeutic purposes.It using tumor tissues self structure it is unsound, heating when compared with normal structure
Radiating is slow, malignant cell to it is high thermo-responsive the characteristics of, act on the DNA of tumor cell of M phases and S phases
Reproduction process, the synthesis of interferencing protein makes death of neoplastic cells or apoptosis, and normal structure is injury-free.
The classification of modern technique for hyperthermia has various different classification forms, and whole body heat can be divided into according to heated perimeter
Treat and part or region thermotherapy, 4 classes can be divided into according to treatment temperature：Middle low temperature thermotherapy, conventional thermotherapy, height
Warm is treated and heating ablation.
Whole-body hyperthermia refers to uniformly to be raised body temperature with the method for biophysics, is killed using fuel factor
Go out cancer cell, suppresses and prevention cancer return, the treatment method of transfer.Existing whole-body hyperthermia apparatus heats skill
Art has：Extracorporal circulatory system heating, heating using microwave cabin, infra-red radiation cabin heating, interior raw field whole body thermotherapy system with
And blood vessel is implanted into hot seed mode of heating.
Heating using microwave cabin, the heating of infra-red radiation cabin, interior raw field whole body thermotherapy system etc. due to technology restriction, plus
The powerful heat sinking function of upper human body, whole body difficult to realize is warming up to can carry out 42 DEG C of levels for consolidating thermotherapy.
Extracorporal circulatory system method refers to be drawn internal body portion blood with special equipment to carry out heating up to pre- constant temperature in vitro
After degree, be re-circulated into vivo reach liter high fever method, because equipment and it is costly, cumbersome not
Easily popularization.Extracorporal circulatory system heating technique needs to use a large amount of heparin as anti-coagulants, blood in course of conveying,
Power is produced by centrifugal pump, through heat exchanger etc. multiple links feed back again in vivo, extracorporal circulatory system heating just like
Lower shortcoming：1st, it is larger to hemodynamic effect；2nd, there is certain destruction to haemocyte；3rd, blood
Easily the foreign matters such as plasticiser, microparticle are mixed into by PVC pipeline etc. enter human body.
Blood vessel is implanted into hot seed mode of heating and must fix hot seed with metal net support, can not be taken out after implantation,
Anticoagulant must be throughout one's life taken, the risk of thrombosis and bleeding is increased.
The content of the invention
In order to solve the deficiency of existing various whole-body hyperthermia technologies, it is necessary to one kind can conveniently, safely be realized
Technique for hyperthermia that whole body heats up, device and method solve the problem of tumour multiple organ transfer.
The present invention provides a kind of Ink vessel transfusing LASER HEATING whole body thermal therapy instrument, including：Interposing catheter, laser occurs
Device, laser pulse width modulation system, Thermometer System and computer control system, interposing catheter have top
End and end, one end of laser generator is connected with the end of interposing catheter, the other end of laser generator and
Laser pulse width modulation system is connected, and laser pulse width modulation system is connected with computer control system, temperature monitoring
System is connected with the end of interposing catheter, while Thermometer System is connected with computer control system.
Further, interposing catheter include body, metallic target, the first thermistor, the second thermistor,
3rd thermistor, laser fiber coupling terminal and temperature survey electrode terminal, metallic target, the first thermistor and
Second thermistor is arranged at the top of body, and the rear portion of metallic target has the first thermistor hole and the second heat
Quick resistance hole, the first thermistor is embedded in the first thermistor hole, and the second thermistor is embedded in second
In thermistor hole, the 3rd thermistor is arranged at the middle part of body, and laser fiber coupling terminal and temperature survey electricity
Extreme son is arranged at the end of body, and laser fiber coupling terminal is connected with laser generator, and temperature surveys electrode tip
Son is connected with Thermometer System.
Further, metallic target surface helically line style, the front end of metallic target also has indent fixing hole, PU
Cap is coated on the front end of metallic target by way of injection moulding and is filled in indent fixing hole, makes PU caps
The front end of metallic target is fixed on, protection is played a part of to metallic target, temperature surveys electrode terminal includes that the first temperature is surveyed
Terminal, the second temperature survey terminal, the 3rd warm terminal, the 4th temperature surveyed and survey terminal, the 5th temperature survey terminal and the 6th temperature
Survey terminal.
Further, body includes that pipe sleeve, laser fiber and temperature survey wire, and it is equal that laser fiber and temperature survey wire
It is arranged inside pipe sleeve, the top of laser fiber is connected with metallic target, the end of laser fiber and laser fiber
Coupling terminal connect, temperature survey wire include first temperature survey wire, second temperature survey wire, the 3rd temperature survey wire,
4th temperature surveys wire, the 5th temperature survey wire and the 6th temperature and surveys wire.
Using the treatment method of above-mentioned Ink vessel transfusing LASER HEATING whole body thermal therapy instrument, comprise the following steps：
Under step (1) general anesthesia, protect patient's cranium brain not by fire damage high using ice cap, whole body is arranged using insulation
Apply (infrared whole body heating compartment)；
Step (2) vital sign is monitored；
Step (3) left lower extremity or right lower extremity femoral venous puncture intubation, interposing catheter are inserted along femoral vein, root
Scale according to interposing catheter surface confirms insertion depth, is located at metallic target and crosses left and right common iliac vein meet,
About in the inferior caval vein of fourth lumbar vertebra level；
Step (4) couples the laser fiber coupling terminal on interposing catheter with external laser generator, by temperature
The temperature for surveying electrode terminal connection external device surveys electrode terminal, opens lasing light emitter and begins to warm up, and makes metallic target temperature
Degree is maintained at 46 DEG C of levels；
Step (5) temperature rise period：As blood is flowed through around metallic target, blood is gradually heated up, directly
42 ± 0.5 DEG C are indicated to second temperature sensing point, during being somebody's turn to do, LASER HEATING power is in dynamic regulation all the time
In, i.e., according to the first temperature sensing point and the data of second temperature sensing point, adjust automatically laser pulse width,
The first temperature sensing point is set to be maintained at 46 ± 0.1 DEG C, second temperature sensing point reaches 42 ± 0.5 DEG C from 37 DEG C,
About two hours；
Step (6) the constant temperature stage：Second temperature sensing point is kept to maintain 42 ± 0.5 DEG C of this states one small
When；
Step (7) temperature-fall period：Lasing light emitter is closed, infrared heating source is closed, temperature heating compartment is opened, given
Give Physical temperature-lowering, body temperature that resuscitation is applied when being down to less than 38 DEG C, observe more than 2 hours, treat every life entity
Levy recovery normal.
Using the Ink vessel transfusing LASER HEATING whole body thermal therapy instrument that the present invention is provided, can be made with safe and simple reaching
Entire patient's temperature is increased to 42.5 ± 0.5 DEG C for the treatment of temperature range, and interposing catheter can the trouble of indwelling in a short time
In person's body, repetitive therapy purpose is reached.After whole courses for the treatment of terminate, it is convenient to withdraw from interposing catheter, body
Any foreign matter is not stayed inside, this method avoid the foreign matters such as hot seed and network are inserted, from without thrombus shape
Into with take the risk that anti-coagulants brings throughout one's life, also will not because of extracorporal circulatory system to the circulatory system caused by it is serious
Complication.
Brief description of the drawings
Technical scheme in order to illustrate more clearly the embodiments of the present invention, institute in being described to embodiment below
The accompanying drawing for needing to use is briefly described, it should be apparent that, drawings in the following description are only the present invention
Some embodiments, for those of ordinary skill in the art, on the premise of not paying creative work,
Other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is Ink vessel transfusing LASER HEATING whole body thermal therapy instrument attachment structure schematic diagram of the invention；
Fig. 2 is the interposing catheter structural representation of Ink vessel transfusing LASER HEATING whole body thermal therapy instrument of the invention.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clearly
Chu, it is fully described by, it is clear that described embodiment is only a part of embodiment of the invention, rather than
Whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creation
Property work on the premise of the every other embodiment that is obtained, belong to the scope of protection of the invention.
Specific embodiment
As shown in figure 1, being Ink vessel transfusing LASER HEATING whole body thermal therapy instrument attachment structure schematic diagram of the invention, blood
LASER HEATING whole body thermal therapy instrument (100) includes in pipe：Interposing catheter (102), laser generator (104),
Laser pulse width modulation system (106), Thermometer System (108) and computer control system (110),
Interposing catheter has top and end, and one end of laser generator is connected with the end of interposing catheter, laser hair
The other end of raw device is connected with laser pulse width modulation system, laser pulse width modulation system and computer control system
Connection, Thermometer System is connected with the end of interposing catheter, while Thermometer System and computer controls
System is connected.
As shown in Fig. 2 being the interposing catheter structural representation of Ink vessel transfusing LASER HEATING whole body thermal therapy instrument of the invention
Figure, interposing catheter includes body (112), metallic target (114), the first thermistor (116), the second heat
Quick resistance (118), the 3rd thermistor (120), laser fiber coupling terminal (122) and temperature survey electrode tip
Sub (124), metallic target, the first thermistor and the second thermistor are arranged at the top of body, metallic target
Rear portion there is the first thermistor hole and the second thermistor hole, the first thermistor is embedded in the first temperature-sensitive
In resistance hole, the second thermistor is embedded in the second thermistor hole, the first thermistor and the second temperature-sensitive
The position of resistance is the first temperature sensing point of interposing catheter, and the 3rd thermistor is arranged at the middle part of body,
The position of the 3rd thermistor is the second temperature sensing point of interposing catheter, and laser fiber coupling terminal and temperature are surveyed
Electrode terminal is arranged at the end of body, and laser fiber coupling terminal is connected with laser generator, and temperature surveys electrode
Terminal is connected with Thermometer System.Tube surfaces have scale, and metallic target is laser closed metal target, gold
Belong to the material of target for copper is gold-plated, laser irradiation metallic target can produce heat, metallic target surface helically line style,
It is beneficial to turbulization when blood passes through, improves heat transfer efficiency.The front end of metallic target also has indent fixing hole,
PU caps are coated on the front end of metallic target by way of injection moulding and are filled in indent fixing hole, make PU
Cap is fixed on the front end of metallic target, plays a part of protection to metallic target, the PU caps diameter of metallic target front end and
The diameter of body is all higher than the diameter of metallic target so that the metallic target in heating will not be contacted with vascular wall, be kept away
Exempt from high-temperature damage vascular wall.First thermistor, the second thermistor and the 3rd thermistor are negative temperature
Coefficient resistance.Temperature surveys electrode terminal includes that the first temperature survey terminal, the second temperature survey terminal, the 3rd temperature and survey end
Son, the 4th temperature survey terminal, the 5th temperature survey terminal and the 6th temperature and survey terminal.
Body includes that pipe sleeve, laser fiber and temperature survey wire, and laser fiber and temperature survey wire and may be contained within pipe sleeve
It is internal.The material of pipe sleeve is polyurethane (PU), and casing surface is coated with superslide coating, the top of laser fiber
It is connected with metallic target, the end of laser fiber is connected with laser fiber coupling terminal, and laser fiber is flexible light
Lead fiber.
Temperature survey wire includes that the first temperature surveys wire, the second temperature survey wire, the 3rd temperature and surveys wire, the 4th temperature and survey and lead
Line, the 5th temperature survey wire and the 6th temperature surveys wire, and the first temperature surveys wire and the second temperature surveys the top and the of wire
One thermistor is connected, and terminal is surveyed in end with the first temperature respectively and the second temperature is surveyed terminal and is connected, and the 3rd temperature is surveyed and led
The top that line and the 4th temperature survey wire be connected with the second thermistor, end survey terminal warm with the 3rd and the respectively
Four temperature survey terminal connection, and the top that the 5th temperature survey wire and the 6th temperature survey wire is connected with the 3rd thermistor,
Terminal is surveyed in end with the 5th temperature respectively and the 6th temperature is surveyed terminal and is connected.The material that temperature surveys wire is oxygen-free copper, plating
Silver wire or fine silver wire.
The operation principle of Ink vessel transfusing LASER HEATING whole body thermal therapy instrument of the invention：
When Ink vessel transfusing LASER HEATING whole body thermal therapy instrument of the invention works, computer control system is by intervention
Blood heat around supravasal thermosensitive resistance measurement laser metal target, and control signal is provided gives laser arteries and veins
Modulating system wide.When temperature is less than setting value (48 DEG C), the pulsewidth of laser generator wide is adjusted, make laser
Generator power output increases, and improves the temperature of metallic target；When close to or up setting value (48 DEG C),
The pulse width of laser generator is turned down, makes metallic target temperature stabilization at 48 ± 0.5 DEG C, to reach quick rising
Blood heat, and by blood circulation, the purpose for making whole body temperature be increased to 42 ± 1 DEG C.
Using the treatment method of above-mentioned Ink vessel transfusing LASER HEATING whole body thermal therapy instrument, comprise the following steps：
Under step (1) general anesthesia, protect patient's cranium brain not by fire damage high using ice cap, whole body is arranged using insulation
Apply (infrared whole body heating compartment)；
Step (2) vital sign is monitored；
Step (3) left lower extremity or right lower extremity femoral venous puncture intubation, interposing catheter are inserted along femoral vein, root
Scale according to interposing catheter surface confirms insertion depth, is located at metallic target and crosses left and right common iliac vein meet,
About in the inferior caval vein of fourth lumbar vertebra level；
Step (4) couples the laser fiber coupling terminal on interposing catheter with external laser generator, by temperature
The temperature for surveying electrode terminal connection external device surveys electrode terminal, opens lasing light emitter and begins to warm up, and makes metallic target temperature
Degree is maintained at 46 DEG C of levels；
Step (5) temperature rise period：As blood is flowed through around metallic target, blood is gradually heated up, directly
42 ± 0.5 DEG C are indicated to second temperature sensing point, during being somebody's turn to do, LASER HEATING power is in dynamic regulation all the time
In, i.e., according to the first temperature sensing point and the data of second temperature sensing point, adjust automatically laser pulse width,
The first temperature sensing point is set to be maintained at 46 ± 0.1 DEG C, second temperature sensing point reaches 42 ± 0.5 DEG C from 37 DEG C,
About two hours；
Step (6) the constant temperature stage：Second temperature sensing point is kept to maintain 42 ± 0.5 DEG C of this states one small
When；
Step (7) temperature-fall period：Lasing light emitter is closed, infrared heating source is closed, temperature heating compartment is opened, given
Give Physical temperature-lowering, body temperature that resuscitation is applied when being down to less than 38 DEG C, observe more than 2 hours, treat every life entity
Levy recovery normal.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, it is all in this hair
Within bright spirit and principle, any modification, improvement, equivalent for being made etc. should be included in this hair
Within bright protection domain.
Claims (7)
1. a kind of Ink vessel transfusing LASER HEATING whole body thermal therapy instrument, including：Interposing catheter, laser generator, laser pulse width
Modulating system, Thermometer System and computer control system, the interposing catheter have top and end
End, one end of the laser generator is connected with the end of the interposing catheter, the laser generator
The other end is connected with the laser pulse width modulation system, the laser pulse width modulation system and the computer
Control system is connected, and the Thermometer System is connected with the end of the interposing catheter, while the body
Warm monitoring system is connected with the computer control system；Characterized in that, the interposing catheter includes pipe
Body, metallic target, the first thermistor, the second thermistor, the 3rd thermistor, laser fiber coupling
Terminal and temperature survey electrode terminal, the metallic target, first thermistor and second thermistor
The top of the body is arranged at, the rear portion of the metallic target has the first thermistor hole and the second temperature-sensitive
Resistance hole, first thermistor is embedded in the first thermistor hole, the second temperature-sensitive electricity
Resistance is embedded in the second thermistor hole, and the 3rd thermistor is arranged in the body
Portion, the laser fiber coupling terminal and the temperature survey the end that electrode terminal is arranged at the body.
2. Ink vessel transfusing LASER HEATING whole body thermal therapy instrument according to claim 1, it is characterised in that：The body
Wire is surveyed including pipe sleeve, laser fiber and temperature, the laser fiber and the temperature survey wire and may be contained within institute
State inside pipe sleeve.
3. Ink vessel transfusing LASER HEATING whole body thermal therapy instrument according to claim 1, it is characterised in that：The metal
Target is laser closed metal target, and the material of the metallic target is that copper is gold-plated, and the metallic target surface is helically
Line style.
4. Ink vessel transfusing LASER HEATING whole body thermal therapy instrument according to claim 3, it is characterised in that：The metal
The front end of target also has indent fixing hole, and PU caps are coated on the metallic target by way of injection moulding
Front end and it is filled in the indent fixing hole, the PU caps is fixed on the front end of the metallic target.
5. Ink vessel transfusing LASER HEATING whole body thermal therapy instrument according to claim 1, it is characterised in that：Described first
Thermistor, second thermistor and the 3rd thermistor are negative temperature coefficient thermistor power
Resistance.
6. Ink vessel transfusing LASER HEATING whole body thermal therapy instrument according to claim 2, it is characterised in that：The laser
The top of optical fiber is connected with the metallic target, the end of the laser fiber and the laser fiber coupled end
Son connection, the laser fiber is flexible light-transmitting fibre.
7. Ink vessel transfusing LASER HEATING whole body thermal therapy instrument according to claim 2, it is characterised in that：The temperature is surveyed
Electrode terminal include first temperature survey terminal, second temperature survey terminal, the 3rd temperature survey terminal, the 4th temperature survey terminal,
5th temperature surveys terminal and the 6th temperature surveys terminal, and the temperature surveys wire includes that the first temperature is surveyed wire, the second temperature and surveyed
Wire, the 3rd temperature survey wire, the 4th temperature survey wire, the 5th temperature surveys wire and the 6th temperature surveys wire, described
First temperature surveys wire and the top of the second temperature survey wire is connected with first thermistor, end point
Terminal is not surveyed with the described first temperature and second temperature is surveyed terminal and be connected, the 3rd temperature survey wire and described
The top that 4th temperature surveys wire is connected with second thermistor, and end is surveyed in end with the described 3rd temperature respectively
Sub and described 4th temperature surveys terminal connection, and the 5th temperature surveys wire and the 6th temperature surveys the top of wire
It is connected with the 3rd thermistor, terminal is surveyed in end with the described 5th temperature respectively and the 6th temperature surveys end
Son connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510444497.0A CN106691675A (en) | 2015-07-24 | 2015-07-24 | Intravascular laser heating whole body thermal therapy instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510444497.0A CN106691675A (en) | 2015-07-24 | 2015-07-24 | Intravascular laser heating whole body thermal therapy instrument |
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| Publication Number | Publication Date |
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| CN106691675A true CN106691675A (en) | 2017-05-24 |
Family
ID=58894814
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510444497.0A Pending CN106691675A (en) | 2015-07-24 | 2015-07-24 | Intravascular laser heating whole body thermal therapy instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112891056A (en) * | 2021-01-28 | 2021-06-04 | 云南科威液态金属谷研发有限公司 | Radio frequency thermotherapy system |
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Application publication date: 20170524 |
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| RJ01 | Rejection of invention patent application after publication |