CN106668965A - Balloon counterpulsation driven mechanical auxiliary circulating device with valves - Google Patents
Balloon counterpulsation driven mechanical auxiliary circulating device with valves Download PDFInfo
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- CN106668965A CN106668965A CN201710010940.2A CN201710010940A CN106668965A CN 106668965 A CN106668965 A CN 106668965A CN 201710010940 A CN201710010940 A CN 201710010940A CN 106668965 A CN106668965 A CN 106668965A
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- Prior art keywords
- storage chamber
- blood
- sacculus
- valve
- blood storage
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/424—Details relating to driving for positive displacement blood pumps
- A61M60/427—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being hydraulic or pneumatic
- A61M60/435—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being hydraulic or pneumatic with diastole or systole switching by valve means located between the blood pump and the hydraulic or pneumatic energy source
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1649—Constructional aspects thereof with pulsatile dialysis fluid flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
Abstract
The invention discloses a balloon counterpulsation driven mechanical auxiliary circulating device with valves. The balloon counterpulsation driven mechanical auxiliary circulating device with the valves comprises drainage pipelines, a feeding valve, a balloon counterpulsation system, a blood storage chamber, a discharging valve and infusion pipelines, wherein the balloon counterpulsation system comprises a control system, an alarm system and a balloon; the balloon is connected with the control system and the alarm system through a balloon catheter; the balloon is positioned in the blood storage chamber; two ends of the balloon catheter are respectively connected to the balloon positioned in the blood storage chamber as well as the control system and the alarm system which are positioned on the outside via the infusion pipelines or the drainage pipelines; and the control system controls counterpulsation frequency of the balloon through the balloon catheter, provides a driving force for the blood storage chamber for discharging blood during counterpulsation of the balloon, and controls blood discharge capacity of the blood storage chamber. When the feeding valve, the balloon, the blood storage chamber and the discharging valve are placed in the outside, an external mechanical auxiliary circulating device is formed; and when the feeding valve, the balloon, the blood storage chamber and the discharging valve are placed in the body of a patient, an internal mechanical auxiliary circulating device is formed.
Description
Technical field
The application is related to technical field of medical instruments, specifically, is related to what a kind of ballon pump with valve drove
Mechanical assistance circulating device.
Background technology
As aged tendency of population is aggravated, patients with heart failure is more and more, and almost all of heart disease finally will all walk centripetal force
Exhaustion.Heart failure medical expense is high, and to entire society heavy burden is brought.Heart failure Therapeutic Method limits to, and effect is unsatisfactory.
Especially for advanced heart failure patient, medication effect is very poor, and heart transplantation therapeutic effect is good, but transplanting to face donor serious
After shortage, transplanting the problems such as immunosuppressant, medicine costliness, therefore transplantation treatment Jing years developments, can not still solve root problem.Machine
The appearance of tool assist circulation (Mechanical Circulation Support, MCS), is that the treatment of whole latter stage heart failure brings
One line dawn.MCS can increase the cardiac output of patients with heart failure, mitigate the load in front and back of heart, so as to reduce myocardial cell oxygen consumption,
Improve diastolic blood pressure.While part substitutes Cardial pump function, MCS causes heart in resting state, can make cardiac function
Recover.Its effect is rapid certainly, is that Drug therapy is incomparable.
According to therapeutic purposes and the length of non-cutting time, mechanical assistance circulation can be divided into：1. temporary Supporting Therapy, makes
Cardiac Function of Patients has an opportunity to be recovered, for example acute severe myocarditiss, acute myocardial infarction, intractable ventricular arrhythmia, postoperative
Low output etc., can make patient spend acute stage by the help of assist circulation；2. auxiliary supports (Bridege to before transplanting
Transplant Therapy, BTT), for needing to wait for the patient of heart transplantation for heart shortage；3. permanent replacement therapy
(Destination Therapy, DT).
Mechanical assistance circulating device is divided into implanted and non-built-in mode by implantation.Non-built-in mode ventricular assist device with
Based on pneumatic type beating pump, gas-powered power is produced by driver so that blood pump produces pulsation pump blood.Its advantage is construction
It is simple and reliable, do not limited by thoracic cavity size, blood flow is pulsation, and expense is relatively low, convenient management.But its volume is larger, and the life-span has
Limit, is not suitable for implantation within a patient, it is impossible to carry out long-term auxiliary.In recent years, the auxiliary device application of non-built-in mode gradually office
It is limited to the short-term auxiliary of children.Implanted ventricular assist device drives blade with axial-flow pump and centrifugal pump as main flow by motor
Rotation, promotes blood flow, and small volume, implantable thoracic cavity, driver is easy to carry, and only one electric wire is drawn, can for a long time even
Forever replace itself heart.
Ventricular assist device is divided into three generations according to design form.First on behalf of beating pump, and representative is HeartMate XVE,
FDA ratifies it and is used for BTT, ratifies for DT within 2002.Second on behalf of axial-flow pump, and representative is HeartMate II, has bearing and determines
Son.The third generation is centrifugal pump, and representative is HeartWare, using magnetic suspension and hydrodynamic force suspension bearing.In recent years, the implanted heart
Room auxiliary device makes rapid progress, and the new pump of excellent performance continuously emerges.But external matured product can not still enter the country.
Jing completes the matured product of FDA approvals and CE certifications, into Chinese market, it is also desirable to which time and funds are by domestic examination ＆ approval.Together
When, these import equipment prices are high, and the meta-analysises of 6 VAD clinical experiments cost effectiveness ratios of a synthesis find,
HeartMate can be such that the life span of each patient increases by 18.3 months, and expense increased 99,475 dollars.Each VAD implantation
210,000 dollars of patient's average cost, is implanted into again VAD and spends 100,000 dollars.These costs, for domestic patient, it is also difficult to
Receive.
Here it is the difficult present situation that domestic cardiovascular doctor faces：On the one hand there are a large amount of patients for needing and giving treatment to, the opposing party
Face external product is difficult to enter domestic market, and the country there is no matured product can use.So that clinic is in many cases, doctor lacks
Strong weapon, the patient that can only witness originally can give treatment to is swallowed by the serious illness.
The content of the invention
In view of this, technical problems to be solved in this application there is provided what a kind of ballon pump with valve drove
Mechanical assistance circulating device, with the features such as miniaturization, miniaturization, both can in vitro be circulated auxiliary, can be miniaturized again
Intravascular intervention approach is inserted and is circulated auxiliary, can also connect oxygenator as a kind of novel in vitro membrane lung oxygenation device.
In order to solve above-mentioned technical problem, the application has following technical scheme：
The mechanical assistance circulating device that a kind of ballon pump with valve drives, it is characterised in that include：Drainage tube
Road, input valve, ballon pump system, blood storage chamber, output valve and extrusion infusing pipeline, wherein,
The ballon pump system, including：Control system, warning system and sacculus, the sacculus by foley's tube with
The control system and the warning system connect, and are filled with working media in the sacculus, the working media be gas or
Liquid, the volume of the sacculus is 0.1ml to 500ml, and the counterpulsation frequency of the sacculus is 1 beat/min to 100000 beats/min, institute
The counterpulsation pressure for stating sacculus is 1mmHg to 300mmHg；
The sacculus is located in the blood storage chamber, and the two ends of the foley's tube are via the extrusion infusing pipeline or the drain
Pipeline is connected respectively to the sacculus in the blood storage chamber and positioned at external control system and warning system, described
Control system controls the counterpulsation frequency of the sacculus by the foley's tube, provides for the blood storage chamber during ballon pump
The driving force that blood is discharged, control the blood storage chamber goes out blood volume, when the working media in the sacculus is leaked,
The warning system carries out leakage alarm；
The drainage line is connected to the blood storage chamber by the input valve so that blood flow is from the drainage line list
To being input to the blood storage chamber；
The blood storage chamber is connected to the extrusion infusing pipeline by the output valve so that blood flow is unidirectional from the blood storage chamber
Export the extrusion infusing pipeline；
The volume of the blood storage chamber is 0.2ml to 600ml, the input valve and the output valve be valvular metal,
The valving of biovalve, macromolecular material valve or Automated condtrol；
When the input valve, the sacculus, the blood storage chamber and the output valve are placed in into external, body is formed
Outer mechanical assistance circulating device, the input valve, the sacculus, the blood storage chamber and the output valve are placed in vivo
When, form internal mechanical assistance circulating device.
Preferably, wherein：
The sacculus is made using macromolecular material, biomaterial or metal material, or using macromolecular material, biological material
The composite that material and metal material are constituted is made.
Preferably, wherein：
The sacculus is used with or without medication coat, and the sacculus is used with or without hydrophilic coating, and the medicine is applied
Layer includes：Heparin coating and rapamycins coating.
Preferably, wherein：
The drainage line and the extrusion infusing pipeline are cylinder, using metal material, macromolecular material, biomaterial system
Into or using metal material, macromolecular material and biomaterial constitute composite make.
Preferably, wherein：
With or without side opening on the drainage line and the extrusion infusing pipeline, the side opening is used for blood flow from described
Drainage line is input into or from extrusion infusing pipeline output.
Preferably, wherein：
The blood storage chamber is spherical, cylindrical, oval spherical or anomalistic object, using artificial blood vessel, macromolecular material,
The composite system that biomaterial or metal are made or constituted using metal, artificial blood vessel, macromolecular material and biomaterial
Into.
Preferably, wherein：
The drainage line, the extrusion infusing pipeline and the blood storage chamber are used with or without medication coat, the drainage tube
Road, the extrusion infusing pipeline and the blood storage chamber are used with or without hydrophilic coating, the drainage line, the extrusion infusing pipeline and institute
State blood storage chamber and be used with or without macromolecule material coating, the medication coat includes：Heparin coating and rapamycins coating.
Preferably, wherein：
It is described to draw when the input valve, the sacculus, the blood storage chamber and the output valve are placed in into external
The input on flow tube road is connected to vein, right atrium or left ventricle, and the outfan of the extrusion infusing pipeline is connected to vein or tremulous pulse,
The volume of the sacculus is 1ml to 500ml, and the counterpulsation frequency of the sacculus is 0 beat/min to 300 beats/min, the sacculus it is anti-
Pressure of fighting is 1mmHg to 300mmHg, and the discharge blood volume of the blood storage chamber is 0ml/ point to 15000ml/ point.
Preferably, wherein：
When the input valve, the sacculus, the blood storage chamber and the output valve are placed in into internal, the input lobe
Film, the sacculus, the blood storage chamber and the output valve are located in left ventricle or in aorta, and the drainage line Jing is actively
Arteries and veins lobe lobe mouth be located at left ventricle in, the extrusion infusing pipeline in aorta, by blood infusion to the aorta；
The balloon volume is 0.1ml-100ml, and the ballon pump frequency is described from 0 beat/min to 100000 beats/min
It is 0ml/ point to 100000ml/ point that blood storage chamber discharges blood volume, a diameter of 1mm to 30mm of the drainage line.
Preferably, wherein：
When the input valve, the sacculus, the blood storage chamber and the output valve are placed in into internal, the input lobe
Film, the sacculus, the blood storage chamber and the output valve are located in right ventricle or in pulmonary artery, and the drainage line is transpulmonary dynamic
Lobe lobe mouth be located at right ventricle in, the extrusion infusing pipeline in main pulmonary artery, by blood infusion in right ventricle to the main pulmonary artery
It is interior；
The balloon volume is 0.1ml-100ml, and the ballon pump frequency is described from 0 beat/min to 100000 beats/min
It is 0ml/ point to 100000ml/ point that blood storage chamber discharges blood volume, a diameter of 1mm to 30mm of the drainage line.
Compared with prior art, mechanical assistance circulating device described herein, has reached following effect：
First, the mechanical assistance circulating device that the ballon pump with valve provided by the present invention drives, using the teaching of the invention it is possible to provide
High flow capacity circulatory assit, with Miniaturizable and the characteristics of miniaturization, processing technology is simple, both can be circulated in vitro auxiliary
Help, intravascular intervention approach can be miniaturized again and be inserted in human body and is circulated auxiliary, can also connect oxygenator, as it is a kind of newly
Type ECMO device.
Second, in the mechanical assistance circulating device that the ballon pump with valve provided by the present invention drives, drainage tube
Road, extrusion infusing pipeline, sacculus and blood storage chamber are used with or without the medicines such as heparin or rapamycin, are used with or without hydrophilic painting
Layer, effectively prevents drainage line, extrusion infusing pipeline, blood storage chamber and sacculus mural thrombus to be formed, moreover it is possible to prevents from activating platelet, coagulate
Blood factor etc..
3rd, in the mechanical assistance circulating device that the ballon pump with valve provided by the present invention drives, it is input into lobe
Film and output valve are made using the valving etc. of valvular metal, biovalve, macromolecular material valve or Automated condtrol,
Blood flow one-way flow is can effectively ensure that, and with good biocompatibility.
Description of the drawings
Accompanying drawing described herein is used for providing further understanding of the present application, constitutes the part of the application, this Shen
Schematic description and description please does not constitute the improper restriction to the application for explaining the application.In the accompanying drawings：
Fig. 1 is the mechanical assistance circulating device structural representation that described a kind of ballon pump with valve of the present invention drives
Figure；
Fig. 2 is the mechanical assistance circulating device of the driving of the ballon pump with valve in the present invention as external mechanical assistance
The composition schematic diagram of circulating device；
Fig. 3 is the mechanical assistance circulating device of the driving of the ballon pump with valve in the present invention as internal left ventricle machine
The composition schematic diagram of tool auxiliary circulating equipment；
Fig. 4 is the mechanical assistance circulating device of the driving of the ballon pump with valve in the present invention as internal right ventricle machine
The composition schematic diagram of tool auxiliary circulating equipment.
Specific embodiment
As in description and claim some vocabulary used in censuring specific components.Those skilled in the art should
It is understood that hardware manufacturer may call same component with different nouns.This specification and claims are not with name
The difference of title is used as distinguishing the mode of component, but the difference with component functionally is used as the criterion distinguished.Such as logical
The "comprising" of piece description and claim mentioned in is an open language, therefore should be construed to " include but do not limit
In "." substantially " refer in receivable range of error, those skilled in the art can solve described in the range of certain error
Technical problem, basically reaches the technique effect.Additionally, " coupling " word here includes any directly and indirectly electric property coupling
Means.Therefore, if a first device is coupled to a second device described in text, representing the first device can direct electrical coupling
The second device is connected to, or the second device is electrically coupled to indirectly by other devices or coupling means.Description
Subsequent descriptions are to implement the better embodiment of the application, so the description be for the purpose of the rule for illustrating the application,
It is not limited to scope of the present application.The protection domain of the application ought be defined depending on the claims person of defining.
Embodiment 1
The mechanical assistance circulating device driven for a kind of herein described ballon pump with valve shown in Figure 1
Specific embodiment, the mechanical assistance circulating device, including：Drainage line 10, input valve 20, ballon pump system, blood storage chamber
60th, valve 70 and extrusion infusing pipeline 80 are exported, wherein,
The ballon pump system, including：Control system 40, warning system 50 and sacculus 30, the sacculus 30 passes through ball
Ductus bursae 31 is connected with the control system 40 and the warning system 50, and working media is filled with the sacculus 30, described
Working media is gas or liquid, and the volume of the sacculus 30 is 0.1ml to 500ml, and the counterpulsation frequency of the sacculus 30 is 1
Beat/min to 100000 beats/min, the counterpulsation pressure of the sacculus 30 is 1mmHg to 300mmHg；
The sacculus 30 is located in the blood storage chamber 60, the two ends of the foley's tube 31 via the extrusion infusing pipeline 80 or
Drainage line 10 is connected respectively to the sacculus 30 in the blood storage chamber 60 and positioned at the external He of control system 40
Warning system 50, the control system 40 controls the counterpulsation frequency of the sacculus 30, the sacculus by the foley's tube 31
It is that the blood storage chamber 60 provides the driving force for discharging blood during 30 counterpulsation, controls the discharge blood volume of the blood storage chamber 60, when
When working media in the sacculus 30 is leaked, the warning system 50 carries out leakage alarm；
The drainage line 10 is connected to the blood storage chamber 60 by the input valve 20 so that blood flow is from the drain
Pipeline 10 is unidirectionally input to the blood storage chamber 60；
The blood storage chamber 60 is connected to the extrusion infusing pipeline 80 by the output valve 70 so that blood flow is from the storage blood
Unidirectionally the extrusion infusing pipeline 80 is arrived in output for room 60；
The volume of the blood storage chamber 60 is 0.2ml to 600ml, and the input valve 20 and the output valve 70 are metal
The valving of valve, biovalve, macromolecular material valve or Automated condtrol；
When the input valve 20, the sacculus 30, the blood storage chamber 60 and the output valve 70 are placed in into internal, shape
Mechanical assistance circulating device in adult, by the input valve 20, the sacculus 30, the blood storage chamber 60 and the output
When valve 70 is placed in external, external mechanical assistance circulating device is formed.
Input valve 20 and output valve 70 in the application adopts valvular metal, biovalve, macromolecular material valve
Or the valving of Automated condtrol, blood flow one-way flow is ensure that, also with good biocompatibility.In the application
Input valve 20 and export valve 70 and be connected with blood storage chamber 60 by the way of interposing catheter, or directly connect with blood storage chamber 60
Connect.The valving of Automated condtrol for example can be mechanical valve prosthesiss machine etc. in the application.
The working media filled in the sacculus 30 of the application is gas or liquid, and warning system 50 can be monitored in sacculus 30
The leakage situation of working media, even if having a small amount of working media to leak, sacculus 30 will immediately stop counterpulsation, warning system 50
Alarm is sent, timely quick-replaceable sacculus 30 is reminded.
Sacculus 30 in the application is made using macromolecular material, biomaterial or metal material, or using macromolecule material
The composite that material, biomaterial and metal material are constituted is made.
Further, above-mentioned sacculus 30 is used with or without medication coat or hydrophilic coating, and the medication coat includes：Liver
Element coating and rapamycins coating etc..When using medication coat, can effectively prevent the mural thrombus of sacculus 30 from being formed, and can prevent
Only activate platelet, thrombin etc..
Drainage line 10 and the extrusion infusing pipeline 80 in the application for cylinder, using metal material, macromolecular material,
The composite that biomaterial or metal material, macromolecular material and biomaterial are constituted is made.
Further, on the drainage line 10 and the extrusion infusing pipeline 80 can with or without side opening, the side opening
For blood flow being input into from the drainage line 10 or being exported from the extrusion infusing pipeline 80.
Further, above-mentioned drainage line 10 and extrusion infusing pipeline 80 are used with or without medication coat, hydrophilic coating or height
Molecular material coating, the medication coat includes：Heparin coating and rapamycins coating.When using medication coat or macromolecule material
During material coating, can effectively prevent drainage line 10 and the mural thrombus of extrusion infusing pipeline 80 from being formed, and can prevent from activating platelet, blood coagulation
Factor etc..
Blood storage chamber 60 in the application is spherical, cylindrical, oval spherical or anomalistic object, using artificial blood vessel, height
Molecular material, biomaterial or metal are made or using answering that metal, artificial blood vessel, macromolecular material and biomaterial are constituted
Condensation material is made.The content of blood storage chamber 60 accommodates sacculus 30, and the volume of blood storage chamber 60 is relatively fixed, if placed using intervention approach
Blood storage chamber volume can have certain change with pressure change, to prevent mural thrombus.Blood storage chamber 60 in the application is in body
It is interior to be inserted by the way of interposing catheter.
The blood storage chamber 60 is used with or without medication coat, hydrophilic coating or macromolecule material coating, and the medicine is applied
Layer includes：Heparin coating and rapamycins coating etc..When using medication coat or macromolecule material coating, can effectively prevent
Drainage line 10 and the mural thrombus of extrusion infusing pipeline 80 are formed, and can prevent from activating platelet, thrombin etc..
The application with valve ballon pump drive mechanical assistance circulating device in, will it is described be input into valve,
When the sacculus, the blood storage chamber and the output valve are placed in external, external mechanical assistance circulating device, the input are formed
Valve, the sacculus, the blood storage chamber and the output valve are located in left ventricle or in aorta, the drainage line Jing master
Arterial valve lobe mouth be located at left ventricle in, the extrusion infusing pipeline in aorta, by blood infusion to the aorta；Now ball
The volume of capsule is 1ml to 500ml, and the counterpulsation frequency of the sacculus is 0 beat/min to 300 beats/min, the counterpulsation pressure of the sacculus
For 1mmHg to 300mmHg, the discharge blood volume of the blood storage chamber is 0ml/ point to 15000ml/ point.
The application with valve ballon pump drive mechanical assistance circulating device in, will it is described be input into valve,
When the sacculus, the blood storage chamber and the output valve are placed in internal, internal mechanical assistance circulating device, the input are formed
Valve, the sacculus, the blood storage chamber and the output valve are located in right ventricle or in pulmonary artery, and the drainage line is transpulmonary
Moving vane lobe mouth is located in right ventricle, and the extrusion infusing pipeline moves blood infusion in right ventricle to the main lung in main pulmonary artery
In arteries and veins；Now balloon volume be 0.1ml-100ml, the ballon pump frequency from 0 beat/min to 100000 beats/min, the storage blood
It is 0ml/ point to 100000ml/ point that blood volume is discharged in room, a diameter of 1mm to 30mm of the drainage line.
Embodiment 2
It is presented below that the mechanical assistance circulating device of the application is applied to external external mechanical assistance circulating device
Application Example, referring to Fig. 2.
On the basis of embodiment illustrated in fig. 1, by the input valve 20, the sacculus 30, the blood storage chamber 60
When being placed in external with the output valve 70, the input of the drainage line 10 is connected to vein or right atrium, drainage line
10 outfan is connected to blood storage chamber 60 by input valve 20, and blood storage chamber 60 is connected to extrusion infusing pipeline by output valve 70
80, the outfan of extrusion infusing pipeline 80 is connected to vein or tremulous pulse.From drainage line 10 to extrusion infusing pipeline 80, blood flow direction can be
From vein to vein, or from vein to tremulous pulse, for example, the input of drainage line 10 may be connected to Jugular vessel, femoral vein,
Superior vena cava, postcava or right atrium, the outfan of extrusion infusing pipeline 80 may be connected to carotid artery, femoral artery, axillary artery, master
Tremulous pulse or some big intravenous etc..
Sacculus 30 is located in blood storage chamber 60, and sacculus 30 is connected to control system 40 and warning system by foley's tube 31
50.Filled with gas or liquid working media in sacculus 30, control system 40 is controlled in sacculus 30 by foley's tube 31
The pressure of gas or liquid so that sacculus 30 carries out counterpulsation.The counterpulsation of sacculus 30 causes the pressure of the blood in blood storage chamber 60 to occur
Change, and then control the discharge blood volume of blood storage chamber 60.
In the embodiment, the volume of sacculus 30 is 60ml, the counterpulsation frequency of the sacculus 30 from 1 beat/min to 200 beats/min, institute
Discharge blood volume 0ml/ point of blood storage chamber 60 is stated to 12000ml/ point.
Input valve 20 and output valve 70 in the embodiment adopts biovalve, valvular metal, macromolecular material lobe
The valving of film or Automated condtrol, it is ensured that blood flow one-way flow, but also with good biocompatibility.Above-mentioned drain
Pipeline 10 and extrusion infusing pipeline 80 are all cylinder, using heparin coating polythene material, prevent mural thrombus from being formed or preventing from swashing
Promoting blood circulation platelet, thrombin etc..
External mechanical assistance circulating device in the embodiment can connect oxygenator, constitute ECMO device
(ECMO)。
Embodiment 3
It is presented below that the mechanical assistance circulating device of the application is applied to internal mechanical assistance circulating device-left ventricle
Ballon pump systematic difference embodiment, referring to Fig. 3.
On the basis of above-described embodiment 1, by the input valve 20, the sacculus 30, the blood storage chamber 60 and described
When output valve 70 is placed in internal, the input valve 20, the sacculus 30, the blood storage chamber 60 and the output valve 70
In left ventricle or in aorta, the Jing aortic valve lobes mouth of the drainage line 10 is located in left ventricle, the extrusion infusing pipeline 80
Connection aorta, extrusion infusing pipeline 80 is located in aorta, by blood infusion to the aorta.
In the embodiment, drainage line 10 enters left ventricle across aortic valve, and the other end of drainage line 10 is by defeated
Enter valve 20 and be connected to blood storage chamber 60, the input valve 20 ensures that blood flow is unidirectionally drained into blood storage chamber 60 from drainage line 10, stores up
The other end of blood room 60 is connected to extrusion infusing pipeline 80 by output valve 70, and output valve 70 ensures that blood flow is unidirectional from blood storage chamber 60
It is discharged to extrusion infusing pipeline 80.Sacculus 30 is located inside blood storage chamber 60, and foley's tube 30 runs through extrusion infusing pipeline 80, foley's tube 30
One end is connected to sacculus 30, and the other end is connected to control system 40, and the control sacculus 30 altofrequency counterpulsation of control system 40 provides drive
Power, aorta is entered by blood from blood storage chamber 60 via extrusion infusing pipeline 80.The volume of blood storage chamber 60 is relatively fixed, and sacculus 30 is high
The driving force that frequency counterpulsation is provided causes the blood in blood storage chamber 60 not result in aortic obstruction again while entering aorta.
From figure 3, it can be seen that being distributed with side opening on the side wall of extrusion infusing pipeline 80 and drainage line 10, blood is from drainage line
10 side opening enters drainage line 10, and then is input in blood storage chamber 60；When blood in blood storage chamber 60 is exported, blood is from storage blood
The inflow extrusion infusing pipeline of room 60 is after 80s, and blood enters aorta from the side opening of extrusion infusing pipeline 80.
In the present embodiment, sacculus 30 adopt siliceous polyureas amine ester material, the volume of the sacculus 30 be 20ml, the sacculus 30
Counterpulsation frequency is from 1 beat/min to 5000 beats/min, and the blood storage chamber 60 discharges blood volume 0ml/ point to 100000ml/ point, described to draw
A diameter of 4mm on flow tube road 10.Above-mentioned blood storage chamber 60 is that elliptical shape ball is spherical, and the blood storage chamber 60 is inflatable, poly- using heparin coating
Ethylene is made with Nitinol composite.Above-mentioned input valve 20 and output valve 70 adopt bioprosthetic valve, it is ensured that blood flow is unidirectional
Flowing, and with good biocompatibility.
Embodiment 4
It is presented below that the mechanical assistance circulating device of the application is applied to internal mechanical assistance circulating device-right ventricle
Ballon pump systematic difference embodiment, referring to Fig. 4.
On the basis of embodiment illustrated in fig. 1, by the input valve 20, the sacculus 30, the blood storage chamber 60 and institute
Output valve 70 is stated when being placed in internal, the input valve 20, the sacculus 30, the blood storage chamber 60 and the output valve 70
In right ventricle or in pulmonary artery, the transpulmonary moving vane lobe mouth of the drainage line 10 is located in right ventricle, the extrusion infusing pipeline 80
Connection main pulmonary artery, in aorta, by right ventricle blood infusion to the main pulmonary artery.
In the embodiment, drainage line 10 from valve of pulmonary trunk by right ventricle, the other end of drainage line 10
Blood storage chamber 60 is connected to by being input into valve 20, the input valve 20 ensures that blood flow is unidirectionally drained into blood storage chamber from drainage line 10
60, the other end of blood storage chamber 60 is connected to extrusion infusing pipeline 80 by output valve 70, and output valve 70 ensures blood flow from blood storage chamber
60 are unidirectionally discharged to extrusion infusing pipeline 80.Sacculus 30 is located inside blood storage chamber 60, and foley's tube 31 runs through drainage line 10, two ends point
Not Lian Jie sacculus 30 and control system 40, the control sacculus 30 altofrequency counterpulsation of control system 40 provides driving force, by blood from storage
Blood room 60 enters pulmonary artery via extrusion infusing pipeline 80.The volume of blood storage chamber 60 is relatively fixed, what the altofrequency counterpulsation of sacculus 30 was provided
Driving force cause the blood in blood storage chamber 60 enter it is Pulmonic while and do not result in pulmonary artery obstruction.
In the embodiment, the sacculus 30 adopt siliceous polyureas amine ester material, the volume of the sacculus 30 be 10ml, the ball
From 1 beat/min to 10000 beats/min, it is 0ml/ point to 100000ml/ point that the blood storage chamber 60 discharges blood volume to the counterpulsation frequency of capsule 30,
A diameter of 4mm of the drainage line 10, the transpulmonary arterial valve lobe mouth of drainage line 10 is located in right ventricle.Storage in the present embodiment
Blood room 60 is that elliptical shape ball is spherical, and the blood storage chamber 60 is inflatable and volume is relatively fixed, and is closed using heparin coating polyethylene and NiTi
Metal/composite material is made.
As can be seen from Figure 4, side opening is distributed with the side wall of extrusion infusing pipeline 80 and drainage line 10, blood is from drainage line
10 side opening enters drainage line 10, and then is input in blood storage chamber 60；When blood in blood storage chamber 60 is exported, blood is from storage blood
The inflow extrusion infusing pipeline of room 60 is after 80s, and blood enters pulmonary artery from the side opening of extrusion infusing pipeline 80.
Input valve and output valve in the present embodiment is the flap of macromolecular material three.
By various embodiments above, the beneficial effect that the application is present is：
First, the mechanical assistance circulating device that the ballon pump with valve provided by the present invention drives, using the teaching of the invention it is possible to provide
High flow capacity circulatory assit, with Miniaturizable and the characteristics of miniaturization, processing technology is simple, both can be circulated in vitro auxiliary
Help, intravascular intervention approach can be miniaturized again and be inserted in human body and is circulated auxiliary, can also connect oxygenator, as it is a kind of newly
Type ECMO device.
Second, in the mechanical assistance circulating device that the ballon pump with valve provided by the present invention drives, drainage tube
Road, extrusion infusing pipeline, sacculus and blood storage chamber are used with or without the medicines such as heparin or rapamycin, are used with or without hydrophilic painting
Layer, effectively prevents drainage line, extrusion infusing pipeline, blood storage chamber and sacculus mural thrombus to be formed, moreover it is possible to prevents from activating platelet, coagulate
Blood factor etc..
3rd, in the mechanical assistance circulating device that the ballon pump with valve provided by the present invention drives, it is input into lobe
Film and output valve are made using the valving etc. of valvular metal, biovalve, macromolecular material valve or Automated condtrol,
Blood flow one-way flow is can effectively ensure that, and with good biocompatibility.
Those skilled in the art are it should be appreciated that embodiments herein can be provided as method, device or computer program
Product.Therefore, the application can be using complete hardware embodiment, complete software embodiment or with reference to the reality in terms of software and hardware
Apply the form of example.And, the application can be adopted and wherein include the computer of computer usable program code at one or more
The computer program implemented in usable storage medium (including but not limited to disk memory, CD-ROM, optical memory etc.) is produced
The form of product.
Described above illustrates and describes some preferred embodiments of the application, but as previously mentioned, it should be understood that the application
Be not limited to form disclosed herein, be not to be taken as the exclusion to other embodiment, and can be used for various other combinations,
Modification and environment, and can be in invention contemplated scope described herein, by above-mentioned teaching or the technology or knowledge of association area
It is modified.And change that those skilled in the art are carried out and change be without departing from spirit and scope, then all should be in this Shen
Please be in the protection domain of claims.
Claims (10)
1. the mechanical assistance circulating device that a kind of ballon pump with valve drives, it is characterised in that include：Drainage line,
Input valve, ballon pump system, blood storage chamber, output valve and extrusion infusing pipeline, wherein,
The ballon pump system, including：Control system, warning system and sacculus, the sacculus by foley's tube with it is described
Control system and the warning system connect, and working media is filled with the sacculus, and the working media is gas or liquid,
The volume of the sacculus is 0.1ml to 500ml, and the counterpulsation frequency of the sacculus is 1 beat/min to 100000 beats/min, the sacculus
Counterpulsation pressure be 1mmHg to 300mmHg；
The sacculus is located in the blood storage chamber, and the two ends of the foley's tube are via the extrusion infusing pipeline or the drainage line
The sacculus that is connected respectively in the blood storage chamber and positioned at external control system and warning system, the control
System controls the counterpulsation frequency of the sacculus by the foley's tube, provides blood for the blood storage chamber during ballon pump
The driving force that liquid is discharged, control the blood storage chamber goes out blood volume, described when the working media in the sacculus is leaked
Warning system carries out leakage alarm；
The drainage line is connected to the blood storage chamber by the input valve so that blood flow is unidirectionally defeated from the drainage line
Enter to the blood storage chamber；
The blood storage chamber is connected to the extrusion infusing pipeline by the output valve so that blood flow is unidirectionally exported from the blood storage chamber
To the extrusion infusing pipeline；
The volume of the blood storage chamber is 0.2ml to 600ml, and the input valve and the output valve are valvular metal, biology
The valving of valve, macromolecular material valve or Automated condtrol；
When the input valve, the sacculus, the blood storage chamber and the output valve are placed in into external, external machine is formed
Tool auxiliary circulating equipment, when the input valve, the sacculus, the blood storage chamber and the output valve are placed in into internal, shape
Mechanical assistance circulating device in adult.
2. the mechanical assistance circulating device that according to claim 1 ballon pump with valve drives, it is characterised in that institute
State sacculus to make using macromolecular material, biomaterial or metal material, or using macromolecular material, biomaterial and metal material
The composite that material is constituted is made.
3. the mechanical assistance circulating device that according to claim 2 ballon pump with valve drives, it is characterised in that institute
State sacculus and be used with or without medication coat, the sacculus is used with or without hydrophilic coating, and the medication coat includes：Heparin
Coating and rapamycins coating.
4. the mechanical assistance circulating device that according to claim 1 ballon pump with valve drives, it is characterised in that institute
It is cylinder to state drainage line and the extrusion infusing pipeline, is made or is adopted using metal material, macromolecular material, biomaterial
The composite that metal material, macromolecular material and biomaterial are constituted is made.
5. the mechanical assistance circulating device that according to claim 1 ballon pump with valve drives, it is characterised in that institute
With or without side opening on drainage line and the extrusion infusing pipeline is stated, the side opening is used for blood flow is defeated from the drainage line
Enter or from extrusion infusing pipeline output.
6. the mechanical assistance circulating device that according to claim 1 ballon pump with valve drives, it is characterised in that institute
Blood storage chamber is stated for spherical, cylindrical, oval spherical or anomalistic object, using artificial blood vessel, macromolecular material, biomaterial or
Metal make or using metal, artificial blood vessel, macromolecular material and biomaterial constitute composite make.
7. the mechanical assistance circulating device that according to claim 1 ballon pump with valve drives, it is characterised in that institute
State drainage line, the extrusion infusing pipeline and the blood storage chamber and be used with or without medication coat, the drainage line, the infusion
Pipeline and the blood storage chamber are used with or without hydrophilic coating, and the drainage line, the extrusion infusing pipeline and the blood storage chamber are adopted
With or do not adopt macromolecule material coating, the medication coat to include：Heparin coating and rapamycins coating.
8. the mechanical assistance circulating device that according to claim 1 ballon pump with valve drives, it is characterised in that will
When the input valve, the sacculus, the blood storage chamber and the output valve are placed in external, the drainage line it is defeated
Enter end and be connected to vein, right atrium or left ventricle, the outfan of the extrusion infusing pipeline is connected to vein or tremulous pulse, the sacculus
Volume is 1ml to 500ml, and the counterpulsation frequency of the sacculus is 0 beat/min to 300 beats/min, and the counterpulsation pressure of the sacculus is
1mmHg to 300mmHg, the discharge blood volume of the blood storage chamber is 0ml/ point to 15000ml/ point.
9. the mechanical assistance circulating device that according to claim 1 ballon pump with valve drives, it is characterised in that will
When the input valve, the sacculus, the blood storage chamber and the output valve are placed in internal, the input valve, the ball
Capsule, the blood storage chamber and the output valve are located in left ventricle or in aorta, the drainage line Jing aortic valve lobe mouth
In left ventricle, the extrusion infusing pipeline in aorta, by blood infusion to the aorta；
The balloon volume be 0.1ml-100ml, the ballon pump frequency from 0 beat/min to 100000 beats/min, the storage blood
It is 0ml/ point to 100000ml/ point that blood volume is discharged in room, a diameter of 1mm to 30mm of the drainage line.
10. the mechanical assistance circulating device that according to claim 1 ballon pump with valve drives, it is characterised in that
It is the input valve, described when the input valve, the sacculus, the blood storage chamber and the output valve are placed in into internal
Sacculus, the blood storage chamber and the output valve are located in right ventricle or in pulmonary artery, the transpulmonary moving vane lobe mouth of the drainage line
In right ventricle, the extrusion infusing pipeline in main pulmonary artery, by blood infusion in right ventricle to the main pulmonary artery；
The balloon volume be 0.1ml-100ml, the ballon pump frequency from 0 beat/min to 100000 beats/min, the storage blood
It is 0ml/ point to 100000ml/ point that blood volume is discharged in room, a diameter of 1mm to 30mm of the drainage line.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710010940.2A CN106668965A (en) | 2017-01-06 | 2017-01-06 | Balloon counterpulsation driven mechanical auxiliary circulating device with valves |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710010940.2A CN106668965A (en) | 2017-01-06 | 2017-01-06 | Balloon counterpulsation driven mechanical auxiliary circulating device with valves |
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| CN106668965A true CN106668965A (en) | 2017-05-17 |
Family
ID=58850324
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| CN201710010940.2A Pending CN106668965A (en) | 2017-01-06 | 2017-01-06 | Balloon counterpulsation driven mechanical auxiliary circulating device with valves |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107158549A (en) * | 2017-06-29 | 2017-09-15 | 吴强 | For regulating and controlling left ventricle capacity to improve the servicing unit of Cardial pump function |
| CN109966575A (en) * | 2019-05-05 | 2019-07-05 | 北京安生生物技术有限责任公司 | A kind of single saccule counterpulsation formula left ventricular assist device |
| CN110876673A (en) * | 2019-11-08 | 2020-03-13 | 中国医学科学院阜外医院 | Double-air-bag driven counter-pulsation catheter device in aorta |
| CN111298225A (en) * | 2019-12-02 | 2020-06-19 | 李勇 | Balloon heart counterpulsation device comprising electromagnet |
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| CN101485907A (en) * | 2008-01-17 | 2009-07-22 | 姬尚义 | Extra-aortic ballon eounterpulsation type heart chamber auxiliary pump |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107158549A (en) * | 2017-06-29 | 2017-09-15 | 吴强 | For regulating and controlling left ventricle capacity to improve the servicing unit of Cardial pump function |
| CN109966575A (en) * | 2019-05-05 | 2019-07-05 | 北京安生生物技术有限责任公司 | A kind of single saccule counterpulsation formula left ventricular assist device |
| CN110876673A (en) * | 2019-11-08 | 2020-03-13 | 中国医学科学院阜外医院 | Double-air-bag driven counter-pulsation catheter device in aorta |
| CN111298225A (en) * | 2019-12-02 | 2020-06-19 | 李勇 | Balloon heart counterpulsation device comprising electromagnet |
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Application publication date: 20170517 |