CN106666751A - Preparation method of vitamin E soft capsule - Google Patents
Preparation method of vitamin E soft capsule Download PDFInfo
- Publication number
- CN106666751A CN106666751A CN201611094224.9A CN201611094224A CN106666751A CN 106666751 A CN106666751 A CN 106666751A CN 201611094224 A CN201611094224 A CN 201611094224A CN 106666751 A CN106666751 A CN 106666751A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- preparation
- vitamin
- gelatin
- capsule according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 239000007901 soft capsule Substances 0.000 title claims abstract description 34
- 229930003427 Vitamin E Natural products 0.000 title claims abstract description 22
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 239000011709 vitamin E Substances 0.000 title claims abstract description 22
- 235000019165 vitamin E Nutrition 0.000 title claims abstract description 22
- 229940046009 vitamin E Drugs 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 23
- 230000008569 process Effects 0.000 claims abstract description 12
- 108010010803 Gelatin Proteins 0.000 claims abstract description 10
- 239000008273 gelatin Substances 0.000 claims abstract description 10
- 229920000159 gelatin Polymers 0.000 claims abstract description 10
- 235000019322 gelatine Nutrition 0.000 claims abstract description 10
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 10
- 235000012424 soybean oil Nutrition 0.000 claims abstract description 6
- 239000003549 soybean oil Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000008213 purified water Substances 0.000 claims abstract description 4
- 238000003860 storage Methods 0.000 claims abstract description 4
- 238000005406 washing Methods 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 238000004806 packaging method and process Methods 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims abstract 3
- 239000003292 glue Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000008188 pellet Substances 0.000 claims description 6
- 238000004513 sizing Methods 0.000 claims description 4
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 235000019198 oils Nutrition 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 230000008901 benefit Effects 0.000 abstract description 4
- 238000001035 drying Methods 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000006187 pill Substances 0.000 abstract 3
- 239000000499 gel Substances 0.000 abstract 2
- 238000003825 pressing Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 208000001034 Frostbite Diseases 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010021929 Infertility male Diseases 0.000 description 1
- 208000007466 Male Infertility Diseases 0.000 description 1
- 208000021908 Myocardial disease Diseases 0.000 description 1
- 208000026214 Skeletal muscle atrophy Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000025185 skeletal muscle atrophy Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparation method of a vitamin E soft capsule, and belongs to the technical filed of health care product preparation. The method comprises the following steps: quantitatively taking soybean oil and natural vitamin E according to a formula, and uniformly mixing the soybean oil and the natural vitamin E to prepare a content material solution; quantitatively taking gelatin and purified water to be heated together to 60 DEG C, continuing heating to 80 DEG C after the gelatin is added, and then carrying out vacuumizing treatment to prepare a gel solution; putting the content material solution and the gel solution into a soft capsule pill pressing machine to press the soft capsule; carrying out forming and drying treatment on the soft capsule; and carrying out pill washing and pill selection processes on the soft capsule after drying treatment, packaging the soft capsule, and put the soft capsule in storage. The preparation method is simple in preparation technology, has the advantages of large market volume, reasonable production technological design, high input and output, high economic benefit and the like, and can have high return rate.
Description
Technical field
The invention belongs to health products preparing technical field, it is related to soft capsule to prepare direction, and in particular to a kind of vitamin E is soft
The preparation method of capsule.
Background technology
Vitamin E is a kind of liposoluble vitamin, is one of topmost antioxidant also known as tocopherol.It is dissolved in fat
It is water insoluble in the organic solvent such as ethanol, it is unstable to alkali to heat, acid stabilization, it is sensitive to oxygen, it is insensitive but fried to heat
When Vitamin E activity substantially reduce.Tocopherol can promote sex hormone to secrete, and increase man's sperm motility and quantity；Make woman
Female hormone concentration increases, and improves fecundity, prevention of miscarriage, it may also be used for prevent and treat male sterility, burn, frostbite, capillary
The aspects such as angiorrbagia, climacteric metancholia, beauty.Human body be deficient in vitamin E when can cause dysgenesia, muscle, liver, bone
There is defect and exudative diathesis in marrow, brain function exception, erythrocyte hemolysis, embryo, it might even be possible to produce skeletal muscle atrophy,
Some species, with myocardium disease damage.But vitamin E soft capsule preparation technology is complicated in the prior art, high cost is unfavorable for promoting.
The content of the invention
According to above the deficiencies in the prior art, the technical problems to be solved by the invention are to propose a kind of vitamin E flexible glue
The preparation method of capsule, preparation process is simple, with dimensions of market it is big, process design is reasonable, input and output are high, high financial profit
The advantages of, there can be good return rate.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is：A kind of preparation side of vitamin E soft capsule
Method, methods described step includes：
Step one, the well mixed prepared content feed liquid of quantitative soybean oil and natural VE is taken by formula；
Step 2, when taking quantitative gelatin and purified water and being heated to 60 DEG C together, continue to be heated to 80 DEG C after adding gelatin, so
Glue is obtained after vacuumize process afterwards；
Soft capsule is suppressed in step 3, content feed liquid and glue input soft capsule pellet press；
Step 4, to soft capsule sizing, dried process；
Soft capsule after step 5, dried process carries out washing ball, select ball technique after, packaging and storage.
In the above method, the ratio of soybean oil and natural VE is 3 in the step one：2.It is big in the step one
Soya-bean oil and the well mixed process of natural VE include：Mixing crosses 100 mesh sieves after 30 minutes, is obtained after standing 1 to 2 hour interior
Tolerant feed liquid.Continue to be heated to 80 DEG C, it is necessary to heat 2 to 3 hours after adding gelatin in the step 2.Taken out in the step 2
De- filtration treatment is also carried out after vacuum, is incubated at 60 DEG C.Temperature in the step 3 in soft capsule pellet press is 18 to 22
DEG C, relative humidity is 40%.In heat treatment in the step 4, temperature is 18 to 22 DEG C, and relative humidity is 40%, man-hour
4 hours.
Present invention has the advantages that:The preparation method of the vitamin E soft capsule that the present invention is provided is simple, and vitamin E
The huge market demand, process design rationally, input and output are high, high financial profit, can there is good return rate.
Specific embodiment
Below against by the description to embodiment, specific embodiment of the invention such as the shape of involved each component
Mutual alignment and annexation, the effect of each several part and operation principle, manufacturing process and operation between shape, construction, each several part
Application method etc., is described in further detail, to help those skilled in the art to inventive concept of the invention, technical scheme
There is more complete, accurate and deep understanding.
A kind of preparation method of vitamin E soft capsule, method and step includes：
Step one, by 3：2 soybean oils and natural VE for quantitatively taking out appropriate weight are well mixed, and mix 30 minutes
100 mesh sieves are crossed afterwards, and content feed liquid is obtained after standing 1 to 2 hour.
Step 2, when taking quantitative gelatin and purified water and being heated to 60 DEG C together, continue to be heated to 80 DEG C after adding gelatin, protect
Hold 2 to 3 hours, then vacuumize, deaeration treatment after, cross 100 mesh sieves, at 60 DEG C be incubated be obtained glue.
Soft capsule is suppressed in step 3, content feed liquid and glue input soft capsule pellet press, pellet press internal temperature is
18 to 22 DEG C, relative humidity is 40%.
Step 4, to soft capsule sizing, dried process, in heat treatment, temperature is 18 to 22 DEG C, and relative humidity is
40%, a length of 4 hours during sizing, drying temperature is 25 DEG C, and relative humidity is 40%, a length of 18 to 24 hours when drying.
Soft capsule after step 5, dried process carries out washing ball using the ethanol of volume of molecular 95%, after selecting ball technique, warp
Be put in storage after crossing inner packing, inspection and external packing.
It is exemplarily described above in conjunction with to the present invention, it is clear that the present invention is implemented and do not limited by aforesaid way
System, if the improvement of the various unsubstantialities that method of the present invention design and technical scheme are carried out is employed, or not improved general
Design of the invention and technical scheme directly apply to other occasions, within protection scope of the present invention.It is of the invention
Protection domain should be determined by the scope of protection defined in the claims.
Claims (7)
1. a kind of preparation method of vitamin E soft capsule, it is characterised in that methods described step includes：
Step one, the well mixed prepared content feed liquid of quantitative soybean oil and natural VE is taken by formula；
Step 2, when taking quantitative gelatin and purified water and being heated to 60 DEG C together, continue to be heated to 80 DEG C after adding gelatin, then take out
Glue is obtained after application of vacuum；
Soft capsule is suppressed in step 3, content feed liquid and glue input soft capsule pellet press；
Step 4, to soft capsule sizing, dried process；
Soft capsule after step 5, dried process carries out washing ball, after selecting ball technique, packaging and storage.
2. the preparation method of vitamin E soft capsule according to claim 1, it is characterised in that soybean in the step one
The ratio of oil and natural VE is 3：2.
3. the preparation method of vitamin E soft capsule according to claim 1, it is characterised in that soybean in the step one
Oil and the well mixed process of natural VE include：Mixing crosses 100 mesh sieves after 30 minutes, and content is obtained after standing 1 to 2 hour
Material liquid.
4. the preparation method of vitamin E soft capsule according to claim 1, it is characterised in that added in the step 2
Continue to be heated to 80 DEG C after gelatin, it is necessary to heat 2 to 3 hours.
5. the preparation method of vitamin E soft capsule according to claim 1, it is characterised in that take out true in the step 2
De- filtration treatment is also carried out after sky, is incubated at 60 DEG C.
6. the preparation method of vitamin E soft capsule according to claim 1, it is characterised in that flexible glue in the step 3
Temperature in capsule pellet press is 18 to 22 DEG C, and relative humidity is 40%.
7. the preparation method of vitamin E soft capsule according to claim 1, it is characterised in that determining in the step 4
In type treatment, temperature is 18 to 22 DEG C, and relative humidity is 40%, 4 hours of man-hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611094224.9A CN106666751A (en) | 2016-12-02 | 2016-12-02 | Preparation method of vitamin E soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611094224.9A CN106666751A (en) | 2016-12-02 | 2016-12-02 | Preparation method of vitamin E soft capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106666751A true CN106666751A (en) | 2017-05-17 |
Family
ID=58867114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611094224.9A Pending CN106666751A (en) | 2016-12-02 | 2016-12-02 | Preparation method of vitamin E soft capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106666751A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078949A (en) * | 2017-11-28 | 2018-05-29 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of vitamin E soft capsule |
| CN109875975A (en) * | 2019-04-02 | 2019-06-14 | 海南海神同洲制药有限公司 | A kind of natural vitamin E soft capsule preparation process |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751146A (en) * | 2013-12-11 | 2014-04-30 | 天津凯镛药业有限公司 | Vitamin E softgel and preparation method thereof |
-
2016
- 2016-12-02 CN CN201611094224.9A patent/CN106666751A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751146A (en) * | 2013-12-11 | 2014-04-30 | 天津凯镛药业有限公司 | Vitamin E softgel and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078949A (en) * | 2017-11-28 | 2018-05-29 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of vitamin E soft capsule |
| CN109875975A (en) * | 2019-04-02 | 2019-06-14 | 海南海神同洲制药有限公司 | A kind of natural vitamin E soft capsule preparation process |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170517 |
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| RJ01 | Rejection of invention patent application after publication |