CN106665649A - Daily chemical product bacteriostat and preparation method thereof - Google Patents

Daily chemical product bacteriostat and preparation method thereof Download PDF

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Publication number
CN106665649A
CN106665649A CN201611220871.XA CN201611220871A CN106665649A CN 106665649 A CN106665649 A CN 106665649A CN 201611220871 A CN201611220871 A CN 201611220871A CN 106665649 A CN106665649 A CN 106665649A
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antibacterial
cosmetics
everyday use
preparation
bacteriostat
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胡波
钟勇财
谢玉国
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JIANGXI YIXINTANG MEDICAL TECHNOLOGY Co Ltd
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JIANGXI YIXINTANG MEDICAL TECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/14—Boron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/34—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-halogen bonds; Phosphonium salts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/042—Acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/10—Carbonates ; Bicarbonates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/201—Monohydric alcohols linear
    • C11D3/2013—Monohydric alcohols linear fatty or with at least 8 carbon atoms in the alkyl chain
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2041—Dihydric alcohols
    • C11D3/2044—Dihydric alcohols linear
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C11D3/2086—Hydroxy carboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2093—Esters; Carbonates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/30—Amines; Substituted amines ; Quaternized amines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/32—Amides; Substituted amides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/36—Organic compounds containing phosphorus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

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  • Pest Control & Pesticides (AREA)
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  • Cosmetics (AREA)

Abstract

The invention belongs to the technical field of daily chemical product additives and particularly relates to a daily chemical product bacteriostat and a preparation method thereof. The bacteriostat is mainly prepared from components in percentage by mass as follows: 10%-15% of glyceryl monoricinoleate, 5%-10% of choline chloride, 7%-12% of pentanediol, 5%-10% of octanediol, 10%-15% of tetrakis hydroxymethyl phosphonium sulfate, 10%-15% of N-acetyl glucosamine, 5%-8% of sodium citrate, 5%-10% of potassium carbonate, 5%-10% of boric acid and 10%-15% of ethanol. The bacteriostat does not contain heavy metals, has small influence on the environment and is high in safety, raw materials are widely-sourced, and the daily chemical product bacteriostat can be applied to textile, fruit and vegetable cleaning or cleaning type daily chemical products.

Description

A kind of cosmetics of everyday use antibacterial and preparation method thereof
Technical field
The invention belongs to cosmetics of everyday use additive technology field, and in particular to a kind of cosmetics of everyday use antibacterial and its preparation Method.
Background technology
Antibacterial is widely existed in soil and water, and human body also carries considerable antibacterial, and antibacterial can be by various modes Into the internal of people, growth and breeding produces toxin, destroys human defensive system, causes body injury, and the antibacterial having can be People's is internal, affects the health of human body.At present, the mode of human infection antibacterial is typically antihygienic living habit causes, carefully One of bacterium route of transmission is propagated by medicated clothing, and clothes can not only adsorb the antibacterial grown in raw air, and can adsorb people's body surface The antibacterial that skin grows；Other spread of germs approach spread through sex intercourse including food, can infect in soil and air in growing process Antibacterial；Last spread of germs approach is propagated also by the articles for daily use, and it is exactly using front to thing to solve one of approach of antibacterial Product are sterilized.
By adding a certain amount of antibacterial in using product, actor not only can be produced and suppress and kill micro- life The function of thing, while contact of the people with pathogenic bacterium can be blocked effectively, greatly reducing transmission of disease.Antibacterial grinds System starts from the eighties in 20th century, and the development Main way of current antibacterial is right on the basis of preferable sterilization effect is ensured Human-body safety is nontoxic.
Antibacterial is mainly organic antibacterial agent, inorganic antiseptic and complex antimicrobials, wherein using it is relatively broad be multiple Antibacterial is closed, is combined by different types of antibacterial, it is complementary by the synergism between them and high-quality, significantly Improve the performance and use range of antibacterial.
The Chinese patent application of Publication No. 105220469A discloses a kind of NEW TYPE OF COMPOSITE textile antibacterial agent and its application, Including the component of following parts by weight：Tetrakis hydroxymetyl phosphonium sulfuric 0.7-1.5 parts, sodium hypophosphite 2-4 part, sodium hexameta phosphate 1-2 Part, sodium carboxymethyl cellulose 0.1-0.2 parts, 0.1 part of choline chloride, water 80-100 parts.The invention antibacterial without heavy metal and Organic halogen, has no adverse effects to environment, safe；Thermostability is stronger, and the antibiotic property persistent period is long；Simultaneously preparation cost is low Honest and clean, process is simple, it is easy to industrialization promotion, the main antimicrobial component of the invention is phosphate support and choline chloride, and both of which belongs to It is poor to fungi restraining effect in antibacterial antibacterial, it is therefore desirable to further to improve.
Notification number discloses a kind of antibacterial for the Chinese patent of 103002732B, and the antibacterial is by following component (A) antibacterial of the organic solvent combination represented by quaternary ammonium salt and (B) represented by.(A) it is selected from dialkyl dimethyl The quaternary ammonium salt of more than a kind in ammonium salt and alkyl benzyl dimethyl ammonium salt.(B) aromatic alcohols, aromatic aldehyde, the invention are selected from Organic antibacterial agent is mainly used, heat-resisting effect is poor, and chemical stability is poor, and is easily remained on sterilising prods using rear, And organic upper antibacterial toxicity is higher, and microorganism is easily set to produce drug resistance, service life is short.
The content of the invention
In order to solve above-mentioned deficiency of the prior art, the invention provides a kind of cosmetics of everyday use antibacterial and its preparation side Method, the present invention mainly uses organic antibacterial agent and aseptic antibacterial synergism, has good sterilizing to antibacterial and funguses Effect.
Concrete technical scheme of the present invention is as follows,
A kind of cosmetics of everyday use antibacterial, mainly by following mass fraction into being grouped into：Single ricinoleic acid glyceride 10- 15%th, choline chloride 5-10%, pentanediol 7-12%, ethohexadiol 5-10%, tetrakis hydroxymetyl phosphonium sulfuric 10-15%, N- acetyl ammonia Base glucose 10-15%, sodium citrate 5-8%, potassium carbonate 5-10%, boric acid 5-10% and ethanol 10-15%.
Organic anti-bacterial composition is in the composition that the present invention is provided：It is single ricinoleic acid glyceride, choline chloride, pentanediol, pungent Glycol, tetrakis hydroxymetyl phosphonium sulfuric, 2-Acetamido-2-deoxy-D-glucose, sodium citrate and ethanol belong to organic anti-bacterial composition, in addition, chlorine Change choline, pentanediol, ethohexadiol and ethanol not only has good sterilization functions to antibacterial, and has good sterilizing to funguses Effect；Further, invention also uses potassium carbonate, the inorganic antibacterial composition of boric acid, and boric acid funguses are had it is certain Suppression and insect killing effect.
Inventive formulation mainly carries out synergism and antibacterial and funguses is entered using organic antibacterial agent and inorganic antiseptic Row suppresses and sterilizing.It was found that, when organic biocide uses cooperatively potassium carbonate, boric acid, improve the sterilization rate of antibacterial, Er Qieti The high inhibitory action to funguses.
Further, described cosmetics of everyday use antibacterial, by following mass fraction into being grouped into：Single ricinoleic acid Ester 12%, choline chloride 8%, pentanediol 9%, ethohexadiol 7%, tetrakis hydroxymetyl phosphonium sulfuric 13%, 2-Acetamido-2-deoxy-D-glucose 12%th, sodium citrate 7%, potassium carbonate 7%, boric acid 8% and ethanol 12%.
Present invention also offers the preparation method of described cosmetics of everyday use antibacterial, step is：
S1：By single ricinoleic acid glyceride, choline chloride, tetrakis hydroxymetyl phosphonium sulfuric, 2-Acetamido-2-deoxy-D-glucose, citric acid Sodium is added in agitator and stirred, and is heated to 65-75 DEG C, stirs 25-30min, obtains latex A；
S2：Add potassium carbonate, pentanediol and ethohexadiol in the latex A obtained to step S1 while stirring, stir 15- 20min, is down to room temperature, obtains just miscible fluid B；
S3：After boric acid and ethanol mixed dissolution, the pH to 7.0-7.5 of the first miscible fluid A that regulating step S2 is obtained, i.e., .
Further, the mixing speed in step S1 and S2 is 250-300r/min.
Further, step S3 adjusts the pH to 7.2 of just miscible fluid A.
Further, described cosmetics of everyday use antibacterial may apply to yarn fabric antibacterial, fruits and vegetables class abluent or The application of cleaning class cosmetics of everyday use.
Compared with prior art, the present invention has the advantage that as follows：
1st, sterilization effect is good：The composition toxicity that the present invention is used is very low, and organic antibacterial agent is used with inorganic antiseptic compatibility, Both organic antibacterial agent toxicity had been solved high, and has easily made microorganism produce drug resistance, the short shortcoming of service life had also been solved The shortcoming of inorganic antiseptic heavy metal deposition.
2nd, the scope that sterilizes is wide：Not only there is to antibacterial good sterilization effect in the composition that the present invention is used, and to funguses Strain has good sterilization effect.
Specific embodiment
The present invention is further detailed by specific embodiment once, is that those skilled in the art more understand this Bright technical scheme, the single ricinoleic acid glyceride (CAS.1323-38-2) that the present invention is used：The chemical limited public affairs of Jin Jinle (Hunan) Department；Tetrakis hydroxymetyl phosphonium sulfuric (CAS.55566-30-8), 2-Acetamido-2-deoxy-D-glucose (CAS.7512-17-6)：Hubei Ju Sheng sections Skill company limited.
Embodiment 1
A kind of cosmetics of everyday use antibacterial, by following mass fraction into being grouped into：Single ricinoleic acid glyceride 12%, chlorination Choline 8%, pentanediol 9%, ethohexadiol 7%, tetrakis hydroxymetyl phosphonium sulfuric 13%, 2-Acetamido-2-deoxy-D-glucose 12%, sodium citrate 7%th, potassium carbonate 7%, boric acid 8% and ethanol 12%.
The preparation method of described cosmetics of everyday use antibacterial, step is：
S1：By single ricinoleic acid glyceride, choline chloride, tetrakis hydroxymetyl phosphonium sulfuric, 2-Acetamido-2-deoxy-D-glucose, citric acid Sodium is added in agitator and stirred, and is heated to 70 DEG C, stirs 28min, and mixing speed is 275r/min, obtains latex A；
S2：Add potassium carbonate, pentanediol and ethohexadiol in the latex A obtained to step S1 while stirring, stir 18min, Mixing speed is 275r/min, is down to room temperature, obtains just miscible fluid B；
S3：After by boric acid and ethanol mixed dissolution, the pH of the first miscible fluid A that regulating step S2 is obtained is obtained final product to 7.2.
Embodiment 2
A kind of cosmetics of everyday use antibacterial, by following mass fraction into being grouped into：Single ricinoleic acid glyceride 13%, chlorination Choline 10%, pentanediol 7%, ethohexadiol 10%, tetrakis hydroxymetyl phosphonium sulfuric 10%, 2-Acetamido-2-deoxy-D-glucose 15%, citric acid Sodium 5%, potassium carbonate 10%, boric acid 5% and ethanol 15%.
The preparation method of described cosmetics of everyday use antibacterial is similar to Example 1.
Embodiment 3
A kind of cosmetics of everyday use antibacterial, by following mass fraction into being grouped into：Single ricinoleic acid glyceride 15%, chlorination Choline 5%, pentanediol 12%, ethohexadiol 5%, tetrakis hydroxymetyl phosphonium sulfuric 15%, 2-Acetamido-2-deoxy-D-glucose 10%, sodium citrate 8%th, potassium carbonate 5%, boric acid 10% and ethanol 10%.
The preparation method of described cosmetics of everyday use antibacterial is similar to Example 1.
Comparative example 1
A kind of cosmetics of everyday use antibacterial, by following mass fraction into being grouped into：Single ricinoleic acid glyceride 20%, chlorination Choline 8%, pentanediol 9%, ethohexadiol 7%, tetrakis hydroxymetyl phosphonium sulfuric 13%, 2-Acetamido-2-deoxy-D-glucose 12%, sodium citrate 7%th, potassium carbonate 7% and ethanol 12%.
The preparation method of described cosmetics of everyday use antibacterial, step is：
S1：By single ricinoleic acid glyceride, choline chloride, tetrakis hydroxymetyl phosphonium sulfuric, 2-Acetamido-2-deoxy-D-glucose, citric acid Sodium is added in agitator and stirred, and is heated to 70 DEG C, stirs 28min, and mixing speed is 275r/min, obtains latex A；
S2：Add potassium carbonate, ethanol, pentanediol and ethohexadiol in the latex A obtained to step S1 while stirring, stir 18min, mixing speed is 275r/min, is down to room temperature, obtains just miscible fluid B；
It is, without boric acid, to increase the content of single ricinoleic acid glyceride with the difference of embodiment 1.
Test example 1pH is detected
Test method：Embodiment 1-3 and cosmetics of everyday use antibacterial obtained in comparative example 1 are detected respectively using pH detectors PH, as a result for：The antibacterial pH of embodiment 1：7.2；The antibacterial pH of embodiment 2：7.5, the antibacterial pH of embodiment 3：7.0； The antibacterial pH of comparative example 1：9.6.
The bacteriostatic test of test example 2
Subjects：Embodiment 1-3 and cosmetics of everyday use antibacterial obtained in comparative example 1.
Strain：Staphylococcus aureuses, escherichia coli, Candida albicans.
Test method：The antibacterial of 0.1ml is mixed with the water of 100ml, is stirred, be then mixed and made into fine jade with agar Fat culture medium, staphylococcus aureuses, escherichia coli, Candida albicans are seeded in respectively in 3 culture medium, are put into 37 DEG C, Culture 10 hours is carried out in constant temperature incubator, colony counts are observed, sterilizing rate is calculated, matched group (without antibacterial), 1- are set Sterilizing rate=colony counts/matched group colony counts × 100%.
Concrete outcome is as shown in table 1.
The bacteriostasis rate testing result of table 1
Test products Escherichia coli Staphylococcus aureuses Candida albicans
Embodiment 1 100% 98.1% 89.6%
Embodiment 2 100% 97.9% 88.6%
Embodiment 3 100% 96.7% 86.9%
Comparative example 1 100% 82.1% 62.1%
It is right, it is apparent that this testing result shows that antibacterial sterilization effect prepared by embodiment 1-3 is good from table 1 Escherichia coli bacteriostasis rate has reached 100%, and to staphylococcus aureuses bacteriostasis rate more than 96% has been reached, and Candida albicans are pressed down Bacterium rate has reached more than 86%, and wherein embodiment 1 is the optimal proportion of the present invention, bacteriostasis rate highest.And comparative example 1 is to implement Composition is changed on the basis of example 1, the fungistatic effect of staphylococcus aureuses and Candida albicans is changed, illustrate this Compatibility is used between antibacterial composition in invention, and effect is more preferable.
The principle and its effect of above-described embodiment only illustrative present invention, it is of the invention not for limiting.It is any ripe Know the personage of this technology all can carry out modifications and changes, still under the spirit and the scope without prejudice to the present invention to above-described embodiment Should be covered by the claim of the present invention.

Claims (5)

1. a kind of cosmetics of everyday use antibacterial, it is characterised in that it is main by following mass fraction into being grouped into：Single castor oil acid is sweet Grease 10-15%, choline chloride 5-10%, pentanediol 7-12%, ethohexadiol 5-10%, tetrakis hydroxymetyl phosphonium sulfuric 10-15%, N- Acetylglucosamine 10-15%, sodium citrate 5-8%, potassium carbonate 5-10%, boric acid 5-10% and ethanol 10-15%.
2. cosmetics of everyday use antibacterial according to claim 1, it is characterised in that by following mass fraction into being grouped into： Single ricinoleic acid glyceride 12%, choline chloride 8%, pentanediol 9%, ethohexadiol 7%, tetrakis hydroxymetyl phosphonium sulfuric 13%, N- second Acylamino- glucose 12%, sodium citrate 7%, potassium carbonate 7%, boric acid 8% and ethanol 12%.
3. the preparation method of cosmetics of everyday use antibacterial according to claim 1 and 2, it is characterised in that step is：
S1：Single ricinoleic acid glyceride, choline chloride, tetrakis hydroxymetyl phosphonium sulfuric, 2-Acetamido-2-deoxy-D-glucose, sodium citrate are added Enter in agitator and stir, be heated to 65-75 DEG C, stir 25-30min, obtain latex A；
S2：Add potassium carbonate, pentanediol and ethohexadiol in the latex A obtained to step S1 while stirring, stir 15-20min, drop To room temperature, just miscible fluid B is obtained；
S3：After by boric acid and ethanol mixed dissolution, the pH to 7.0-7.5 of the first miscible fluid A that regulating step S2 is obtained is obtained final product.
4. the preparation method of cosmetics of everyday use antibacterial according to claim 3, it is characterised in that stirring in step S1 and S2 Speed is mixed for 250-300r/min.
5. the preparation method of cosmetics of everyday use antibacterial according to claim 3, it is characterised in that step S3 adjusts just miscible The pH of liquid A to 7.2.
CN201611220871.XA 2016-12-26 2016-12-26 Daily chemical product bacteriostat and preparation method thereof Pending CN106665649A (en)

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