CN106620730A - Preparation method of T1/T2 bimodal nano-contrast agent - Google Patents
Preparation method of T1/T2 bimodal nano-contrast agent Download PDFInfo
- Publication number
- CN106620730A CN106620730A CN201710059437.6A CN201710059437A CN106620730A CN 106620730 A CN106620730 A CN 106620730A CN 201710059437 A CN201710059437 A CN 201710059437A CN 106620730 A CN106620730 A CN 106620730A
- Authority
- CN
- China
- Prior art keywords
- nano
- contrast agent
- solution
- preparation
- bimodals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
Abstract
The invention relates to a contrast agent, in particular to a preparation method of a T1/T2 bimodal nano-contrast agent. The preparation method comprises the steps of adding hydrochloric acid into a PB solution until the pH value of the mixed solution is 3-4, and carrying out ultrasonic treatment to obtain a solution A; adding the hydrochloric acid into an MnFe2O4 solution until the pH value of the mixed solution is 4, and carrying out ultrasonic treatment to obtain a solution B; pouring the solution A and the solution B into a container for reacting, separating reaction products, and washing to obtain the T1/T2 bimodal nano-contrast agent. The obtained T1/T2 bimodal nano-contrast agent is magnetic prussian blue nanoparticles, and the particle sizes of the magnetic prussian blue nanoparticles are about 150nm. The T1/T2 bimodal nano-contrast agent is prepared by taking a prussian blue nanocube as a core and enabling manganous ferrite nanoparticles to be stuck on the external face of the core. A prepared material not only can maintain the performance of prussian blue, but also can improve the performance of manganous ferrite, thus being capable of being used for both T1 radiography and T2 radiography; therefore, the T1/T2 bimodal nano-contrast agent has good potential application prospect.
Description
Technical field
The present invention relates to contrast preparation, more particularly, to a kind of preparation method of T1/T2 bimodals nano-contrast agent.
Background technology
Magnetic resonance imaging MRI (Magnetic resonance imaging) is to utilize electromagnetic induction phenomenon, by computer
A kind of noninvasive imaging methods that technology and two dimensional image method for reconstructing are imaged.With high imaging rate, without ionising radiation, energy
The characteristics of multi-level diagnostic message is provided, thus medical science detection in obtain widely with (Qiao Ruirui, Jia Qiaojuan, Zeng Jianfeng,
Deng. superparamag-netic iron oxide and its magnetic resonance imaging application [J]. Acta Biophysica Sinica, 2011,27 (4):272-288.).
Magnetic nanoparticle has superparamagnetic characteristic, and the susceptibility of imaging can be increased in magnetic resonance imaging, so as to show making for uniqueness
Shadow agent function.
The general principle of magnetic resonance imaging：Proton number produces magnetic moment for the atomic nucleus of radix because of its spinning campaign,
The radio-frequency pulse of CF is excited down, and the atomic nucleus can be excited because energy resonance absorbs；After stop pulse, atomic nucleus is released
Release energy and return to ground state and produce relaxation phenomena.Relaxation is divided into vertical and horizontal relaxation, and corresponding longitudinal relaxation time is T1
Time, T2 is the T2 times, and corresponding is T1/T2 imagings.In order to highlight the difference between tissue, especially
Normal structure and pathological tissues, we would generally improve the contrast of magnetic resonance imaging using contrast preparation.
Contrast preparation (also known as contrast medium, contrast agents) is injected (or taking) to strengthen Imaging Study effect
To tissue or the chemicals of organ, imaging is mainly improved and improved by affecting the relaxation of Hydrogen Proton around it
Contrast, corresponding contrast preparation is also classified into T1/T2 contrast preparation.T1 contrast preparation is also called " just strengthening contrast preparation ", mainly leads to
Shortening longitudinal relaxation time is crossed, makes weighting picture brighten, so as to distinguish with other tissues.Typical T1 contrast preparation mainly contains
The metallic compound of gadolinium.With T1 contrast preparation conversely, T2 contrast preparation acts primarily as negative enhancing effect, weighting is made as dimmed, and then and its
Hetero-organization is differentiated.T2 contrast preparation mainly include SPIO nano particle (Qiao Ruirui, Jia Qiaojuan, Zeng Jianfeng, etc.
Superparamag-netic iron oxide and its magnetic resonance imaging application [J]. Acta Biophysica Sinica, 2011,27 (4):272-288.).
Prussian blue (Fe4[Fe(CN)6]3) it is a kind of classical Fe2+And Fe3+The Hexacyanoferrate of Ar ion mixing valence state
Salt, it is Prussian blue to be widely used in sensor, energy because with performances such as excellent structure, optical physics, electrochemistry, electrochromism
Field (Shokouhimehr M, Soehnlen E S, Hao J, the et al.Dual purpose such as amount storage and battery
Prussian blue nanoparticles for cellular imaging and drug delivery:a new
generation of T 1-weighted MRI contrast and small molecule delivery agents
[J].Journal of Materials Chemistry,2010,20(25):5251-5259.).In biological field, this indigo plant
Color material is often used as biological stain, and prussian blue nano material is also got in the concern that the application of biological field is subject to
Come more.
Prussian blue preparation method is very simple, as long as mix iron ion and ferrous cyanide ion being in acid condition
Can, preparing simply, cost is relatively low.Most of all, Prussian blue or a kind of clinical application, is doctor for treating thallium poisoning
Institute and the conventional deposit medicine of pharmacy, and obtained the approval of U.S. FDA.Recently, it has been found that Prussian blue with significant
Magnetic resonance imaging function, is a kind of new T1 weighted magnetic resonance contrast preparation, therefore, there is good prospect in medical imaging.
Manganese Ferrite (MnFe2O4) it is a kind of one pack system ferrite with mixed phase spinelle configuration, because of itself intrinsic thing
Physicochemical property makes it have important use (Shah S A, Majeed A, Rashid K, et in fields such as magnetic, pigment and catalysis
al.PEG-coated folic acid-modified superparamagnetic MnFe 2O 4nanoparticles for
hyperthermia therapy and drug delivery[J].Materials Chemistry and Physics,
2013,138(2):703-708.).Manganese ferrite nanoparticles body is a kind of highly important magnetic Nano material, with very high magnetic
Property, also, Manganese Ferrite magnetic nano-particle has higher relaxation rate in magnetic resonance imaging, and contrasting effects substantially, are usually made
For " negative contrast preparation ", for T2 radiographies.
The content of the invention
It is an object of the invention to provide a kind of preparation method of T1/T2 bimodals nano-contrast agent.
The present invention is comprised the following steps：
1) add hydrochloric acid to pH value to be 3～4 in PB solution, solution A is obtained after ultrasound；
In step 1) in, the mass concentration of the PB solution can be 5mg/ml；The molar concentration of hydrochloric acid can be 6M/L.
2) in MnFe2O4Add hydrochloric acid to be 4 to pH in solution, solution B is obtained after ultrasound；
In step 2) in, the MnFe2O4The mass concentration of solution can be 2mg/ml；The molar concentration of hydrochloric acid can be 6M/L.
3) solution A and solution B are poured in container and is reacted, then product is separated, T1/T2 bimodals are obtained final product after washing
Nano-contrast agent.
In step 3) in, can be stirred during the reaction, stir speed (S.S.) can be 300rpm, and mixing time can be 12h；Institute
Stating separation can adopt Magnetic Isolation；The washing can respectively wash 3 times using ethanol, ultra-pure water respectively.
T1/T2 bimodals nano-contrast agent obtained by the present invention is magnetic prussian blue nano particle (PB-MnFe2O4),
The particle diameter of particle is 150nm or so.
With prussian blue nano cube as core, adhesion manganous ferrite nano-particle in outside prepares a kind of T1/T2 to the present invention
Bimodal nano-contrast agent.Prepared material can both retain Prussian blue performance, it is also possible to increase the performance of Manganese Ferrite,
It both can serve as T1 radiographies, and T2 radiographies are can be used for again, have good potential application foreground in biomedical sector.
The present invention has advantages below：
A) present invention is simple to operate, and reactant is cheap, low cost；Side reaction is few, and product yield is high.
B) the T1/T2 bimodal nano-contrast agents for preparing have good magnetic, and saturation magnetization is 35emu g-1。
C) the T1/T2 bimodal nano-contrast agent uniform particle diameters for preparing, with good dispersiveness and stability, are dispersed in
Can preserve for a long time in absolute ethyl alcohol.
D) the T1/T2 bimodal nano-contrast agents for preparing have good T1/T2Contrasting effects, r1=5.56mM-1s-1,r2
It is worth for 123.46mM-1s-1。
Description of the drawings
Fig. 1 be in embodiment 1 prepare T1/T2 bimodal nano-contrast agents ESEM (SEM) photo (scale be 1 μ
m).From figure 1 it appears that prepared prussian blue nano particle diameter is than more uniform.
Fig. 2 is that (scale is for ESEM (SEM) photo of the T1/T2 bimodal nano-contrast agents prepared in embodiment 1
200nm).From figure 2 it can be seen that prepared prussian blue nano particle diameter is than more uniform.
Fig. 3 is PB, the MnFe prepared in embodiment 12O4And PB-MnFe2O4The X-ray diffraction spectrum of nano-particle.In figure
In 3, curve a is PB, and curve b is PB-MnFe2O4, curve c is PB-MnFe2O4。
Fig. 4 is the Prussian blue solution (PB-MnFe of Prussian blue and magnetic prepared in embodiment 12O4) hysteresis curve
Figure.
Fig. 5 is the T1/T2 bimodal nano-contrast agent (PB-MnFe prepared in embodiment 12O4) T1 relaxation rate curves.Can
To see prepared magnetic prussian blue nano particle (PB-MnFe2O4) there is higher relaxation rate (r1=5.56mM-1s-1), thus can be used as good T1 contrast preparation in the diagnosis of MRI molecular images.
Fig. 6 is the T1/T2 bimodal nano-contrast agent (PB-MnFe prepared in embodiment 12O4) T2 relaxation rate curves.Can
To see prepared magnetic prussian blue nano particle (PB-MnFe2O4) there is higher relaxation rate (r2=123.33mM-1s-1), thus can be used as good T2 contrast preparation in the diagnosis of MRI molecular images.
Fig. 7 is T1 contrast imaging design sketch.It can be seen that prepared T1/T2 bimodal nano-contrast agent (PB-
MnFe2O4) there are good T1 contrasting effects.
Fig. 8 is T2 contrast imaging design sketch.It can be seen that prepared T1/T2 bimodal nano-contrast agent (PB-
MnFe2O4) there are preferable T2 contrasting effects.
Specific embodiment
With reference to embodiment and accompanying drawing, the present invention is described further.
Embodiment 1：
A kind of synthetic method that can be used for T1/T2 bimodal nano-contrast agents, step is as follows：
1) take 10ml, the PB solution of 5mg/ml in container, be added dropwise 10 μ l, the hydrochloric acid of 6M/L to pH value between 3～4,
Ultrasound 2min afterwards, it is determined as solution 1.
2) 10ml, the MnFe of 11.5mg/ml are taken2O4Solution is added dropwise 5 μ l in container, afterwards, and the hydrochloric acid of 6M/L to pH is to being equal to
4, ultrasound 1min afterwards, it is determined as solution 2.
3) and then by solution 1 and solution 2 pour in container simultaneously, mechanical agitation 12h, 300rpm.
4) after reaction terminates, it is found that solution is in blackish green, and magnet is placed on flask side, it can be found that solution is to magnet
It is mobile.
5) by product by Magnetic Isolation, and using ethanol, ultra-pure water three preservations are respectively washed respectively.
Fig. 1 is ESEM (SEM) photo of the T1/T2 bimodal nano-contrast agents prepared in embodiment 1, from Fig. 1
As can be seen that prepared T1/T2 bimodal nano-contrast agent particle diameters are than more uniform, particle diameter 100nm or so.
Fig. 2 is ESEM (SEM) photo of the T1/T2 bimodal nano-contrast agents prepared in embodiment 1, from Fig. 2
As can be seen that prepared T1/T2 bimodal nano-contrast agent particle diameters are than more uniform, it can be seen that manganous ferrite nano-particle adheres to
In Prussian blue surface, particle diameter 150nm or so.
Fig. 3 is PB, the MnFe prepared in embodiment 12O4And PB-MnFe2O4The X-ray diffraction spectrum of nano-particle, from figure
PB, MnFe can be seen in spectrum2O4And PB-MnFe2O4The diffraction maximum of nano-particle sample, is not detected by the second phase.
Fig. 4 is the Prussian blue solution (PB-MnFe of Prussian blue and magnetic prepared in embodiment 12O4) hysteresis curve
Figure.
Fig. 5 is the T1/T2 bimodal nano-contrast agent (PB-MnFe prepared in embodiment 12O4) relaxation rate curve, can be with
See prepared magnetic prussian blue nano particle (PB-MnFe2O4) there is higher relaxation rate (r1=5.56mM-1s-1),
Can be used as good T1 contrast preparation in the diagnosis of MRI molecular images.
Fig. 6 is the T1/T2 bimodal nano-contrast agent (PB-MnFe prepared in embodiment 12O4) T2 relaxation rate curves, can
To see prepared T1/T2 bimodal nano-contrast agent (PB-MnFe2O4) there is higher relaxation rate (r2=123.46mM- 1s-1), can be used as good T2 contrast preparation in the diagnosis of MRI molecular images.
Fig. 7 is T1 contrast imaging design sketch, corresponding concentration referring to table 1, from Fig. 7 and Biao 1 as can be seen that prepared
T1/T2 bimodal nano-contrast agent (PB-MnFe2O4) T1 contrasting effects.
Table 1
| Numbering | Concentration (mM) |
| 1 | 0.0275 |
| 2 | 0.055 |
| 3 | 0.11 |
| 4 | 0.22 |
| 5 | 0.44 |
Fig. 8 is T2 contrast imaging design sketch, corresponding concentration referring to table 2, from Fig. 8 and Biao 2 as can be seen that prepared
T1/T2 bimodal nano-contrast agent (PB-MnFe2O4) T2 contrasting effects.
Table 2
| Numbering | Concentration (mM) |
| 1 | 0.0190625 |
| 2 | 0.038125 |
| 3 | 0.07625 |
| 4 | 0.1525 |
| 5 | 0.305 |
Embodiment 2：
A kind of synthetic method that can be used for T1/T2 bimodal nano-contrast agents, step is a difference in that with embodiment 1,
The MnFe of 10ml, 5mg/ml2O4。
Embodiment 3：
A kind of synthetic method that can be used for T1/T2 bimodal nano-contrast agents, step is a difference in that with embodiment 1,
The MnFe of 10ml, 20mg/ml2O4。
Embodiment 4：
A kind of synthetic method that can be used for T1/T2 bimodal nano-contrast agents, step is a difference in that with embodiment 1, drips
Plus hydrochloric acid is equal to 2 to pH value.
Embodiment 5：
A kind of synthetic method that can be used for T1/T2 bimodal nano-contrast agents, step is a difference in that with embodiment 1, instead
8h between seasonable.
Embodiment 6：
A kind of synthetic method that can be used for T1/T2 bimodal nano-contrast agents, step is a difference in that with embodiment 1, instead
16h between seasonable.
Embodiment 7：
A kind of synthetic method that can be used for T1/T2 bimodal nano-contrast agents, step is a difference in that with embodiment 1, turns
Fast 200rpm.
Embodiment 8：
A kind of synthetic method that can be used for T1/T2 bimodal nano-contrast agents, step is a difference in that with embodiment 1, turns
Fast 400rpm.
The present invention is based on Prussian blue a variety of advantages, further expands its function, is not sacrificing Prussian blue performance
On the basis of, both on the basis of can be as T1 contrast preparation, Manganese Ferrite nano material be introduced, prepare a kind of T1/T2 bimodals and receive
Rice contrast preparation (magnetic prussian blue nano particle) (Jang J, Lee D S.Magnetic Prussian blue
nanocomposites for effective cesium removal from aqueous solution[J]
.Industrial&Engineering Chemistry Research,2016,55(13):3852-3860.), realize Prussia
The blue transformation from nonmagnetic to magnetic, realizes effects of the 1+1 more than 2, and after introducing, this material also has good
T2 radiography functions, it is possible to achieve T1/T2 bimodals are imaged.
Claims (9)
1. a kind of preparation method of T1/T2 bimodals nano-contrast agent, it is characterised in that it is comprised the following steps：
1) add hydrochloric acid to pH value to be 3～4 in PB solution, solution A is obtained after ultrasound；
2) in MnFe2O4Add hydrochloric acid to be 4 to pH in solution, solution B is obtained after ultrasound；
3) solution A and solution B are poured in container and is reacted, then product is separated, T1/T2 bimodal nanometers are obtained final product after washing
Contrast preparation.
2. as claimed in claim 1 a kind of preparation method of T1/T2 bimodals nano-contrast agent, it is characterised in that in step 1)
In, the mass concentration of the PB solution is 5mg/ml.
3. as claimed in claim 1 a kind of preparation method of T1/T2 bimodals nano-contrast agent, it is characterised in that in step 1)
In, the molar concentration of the hydrochloric acid is 6M/L.
4. as claimed in claim 1 a kind of preparation method of T1/T2 bimodals nano-contrast agent, it is characterised in that in step 2)
In, the MnFe2O4The mass concentration of solution is 2mg/ml.
5. as claimed in claim 1 a kind of preparation method of T1/T2 bimodals nano-contrast agent, it is characterised in that in step 2)
In, the molar concentration of the hydrochloric acid is 6M/L.
6. as claimed in claim 1 a kind of preparation method of T1/T2 bimodals nano-contrast agent, it is characterised in that in step 3)
In, it is stirred during the reaction, stir speed (S.S.) is 300rpm, and mixing time is 12h.
7. as claimed in claim 1 a kind of preparation method of T1/T2 bimodals nano-contrast agent, it is characterised in that in step 3)
In, the separation adopts Magnetic Isolation.
8. as claimed in claim 1 a kind of preparation method of T1/T2 bimodals nano-contrast agent, it is characterised in that in step 3)
In, the washing is respectively to wash 3 times using ethanol, ultra-pure water respectively.
9. the T1/T2 bimodal nano-contrast agents that prepared by the preparation method as described in claim 1～8, it is characterised in that the T1/
T2 bimodals nano-contrast agent is magnetic prussian blue nano particle PB-MnFe2O4, with prussian blue nano cube as core, institute
Core outside adhesion manganous ferrite nano-particle is stated, the particle diameter of particle is 150nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710059437.6A CN106620730A (en) | 2017-01-24 | 2017-01-24 | Preparation method of T1/T2 bimodal nano-contrast agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710059437.6A CN106620730A (en) | 2017-01-24 | 2017-01-24 | Preparation method of T1/T2 bimodal nano-contrast agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106620730A true CN106620730A (en) | 2017-05-10 |
Family
ID=58841579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710059437.6A Pending CN106620730A (en) | 2017-01-24 | 2017-01-24 | Preparation method of T1/T2 bimodal nano-contrast agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106620730A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578698A (en) * | 2018-05-18 | 2018-09-28 | 厦门大学 | Purposes of the Prussian blue-Manganese Ferrite composite nano materials as magnetic heat/photo-thermal combination therapy agent |
| CN116077659A (en) * | 2023-04-11 | 2023-05-09 | 山东大学 | Microminiature Janus nano particle and preparation method and application thereof |
-
2017
- 2017-01-24 CN CN201710059437.6A patent/CN106620730A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| AGNIESZKA SZPAK等: ""T1–T2 Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes"", 《J NANOPART RES》 * |
| XIZHOU等: ""Porous MnFe2O4-decorated PB nanocomposites:a new theranostic agent for boosted T1/T2 MRI guided synergistic photothermal/magnetic hyperthermia"", 《RSC ADVANCES》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578698A (en) * | 2018-05-18 | 2018-09-28 | 厦门大学 | Purposes of the Prussian blue-Manganese Ferrite composite nano materials as magnetic heat/photo-thermal combination therapy agent |
| CN116077659A (en) * | 2023-04-11 | 2023-05-09 | 山东大学 | Microminiature Janus nano particle and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bao et al. | Magnetic iron oxide nanoparticles as T 1 contrast agents for magnetic resonance imaging | |
| Jeon et al. | Iron oxide nanoparticles as T1 contrast agents for magnetic resonance imaging: fundamentals, challenges, applications, and prospectives | |
| Caspani et al. | Magnetic nanomaterials as contrast agents for MRI | |
| Shen et al. | Iron oxide nanoparticle based contrast agents for magnetic resonance imaging | |
| Peng et al. | Nanostructured magnetic nanocomposites as MRI contrast agents | |
| Zhao et al. | Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging | |
| Barick et al. | Novel and efficient MR active aqueous colloidal Fe 3 O 4 nanoassemblies | |
| Wu et al. | Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy | |
| Patel et al. | The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents | |
| Xu et al. | Paramagnetic nanoparticle T 1 and T 2 MRI contrast agents | |
| Eom et al. | 2-Dimensional nanomaterials with imaging and diagnostic functions for nanomedicine; a review | |
| Cheung et al. | Polymer-stabilized lanthanide fluoride nanoparticle aggregates as contrast agents for magnetic resonance imaging and computed tomography | |
| Baek et al. | Water-soluble MnO nanocolloid for a molecular T 1 MR imaging: a facile one-pot synthesis, in vivo T 1 MR images, and account for relaxivities | |
| Jeong Kim et al. | Gadolinium oxide nanoparticles as potential multimodal imaging and therapeutic agents | |
| Akakuru et al. | The transition from metal-based to metal-free contrast agents for T 1 magnetic resonance imaging enhancement | |
| Liu et al. | Water-dispersible magnetic carbon nanotubes as T2-weighted MRI contrast agents | |
| Hurley et al. | Effects of mesoporous silica coating and postsynthetic treatment on the transverse relaxivity of iron oxide nanoparticles | |
| Li et al. | Multifunctional BaYbF5: Gd/Er upconversion nanoparticles for in vivo tri-modal upconversion optical, X-ray computed tomography and magnetic resonance imaging | |
| WO2011106309A2 (en) | Materials and methods for mri contrast agents and drug delivery | |
| Ha et al. | Development of target-specific multimodality imaging agent by using hollow manganese oxide nanoparticles as a platform | |
| Neamtu et al. | Magnetic nanoparticles for magneto-resonance imaging and targeted drug delivery | |
| Antwi‐Baah et al. | Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation | |
| CN102657881B (en) | Preparation method of Fe3O4 nano-magnetic resonance contrast medium material | |
| CN106620730A (en) | Preparation method of T1/T2 bimodal nano-contrast agent | |
| CN110384805A (en) | A kind of Superparamagnetic Iron Oxide nanocluster body and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |