CN106592017B - A kind of preparation method of the pure sodium alginate nano fiber based on electrostatic spinning shapes - Google Patents
A kind of preparation method of the pure sodium alginate nano fiber based on electrostatic spinning shapes Download PDFInfo
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- CN106592017B CN106592017B CN201610977244.4A CN201610977244A CN106592017B CN 106592017 B CN106592017 B CN 106592017B CN 201610977244 A CN201610977244 A CN 201610977244A CN 106592017 B CN106592017 B CN 106592017B
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
- D01F9/04—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments of alginates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D1/00—Treatment of filament-forming or like material
- D01D1/02—Preparation of spinning solutions
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
Abstract
The invention discloses a kind of preparation methods of pure sodium alginate electro spinning nano fiber, it mixes sodium alginate soln with sodium periodate solution, and use ethylene glycol as terminator to control the degree that oxidation reaction carries out, oxidation product is precipitated with excess ethyl alcohol again, it is redissolved after centrifuge separation, purification of dialysing, obtains pure high aldehyde sodium alginate powder；Then, routinely electrostatic spinning process requires to be configured to spinning solution, enters spinning forming in electrostatic spinning apparatus.The present invention aoxidizes sodium alginate using strong oxidizer sodium metaperiodate, pass through the open loop of the saccharide ring on sodium alginate, and more aldehyde radicals are introduced on strand, the entanglement degree in spinning solution between sodium alginate strand and sodium alginate strand is effectively improved, realizes pure sodium alginate solution from can not spin spinnable transformation.The present invention has the characteristics that simple process, controllable, stable product quality, obtained sodium alginate nano fiber degree of purity are high.
Description
Technical field
The present invention relates to a kind of preparation methods of sodium alginate nano fiber, more particularly to one kind to be based on electrostatic spinning shapes
Pure sodium alginate nano fiber preparation method.
Background technique
Sodium alginate also known as sodium alginate, it is that (G is mono- with β-D- guluronic acid by α-L- mannuronic acid (M unit)
Member) pass through a kind of linear natural polymer made of Isosorbide-5-Nitrae-glucosides key connection.
Current research conclusion is that pure sodium alginate solution is to cannot function as spinning solution directly to carry out electrostatic spinning (ginseng
See: Adv.Mater.2006,18,1463-1467) the reason is that, sodium alginate is a kind of stronger polyanion electrolyte of rigidity,
The mutual winding of sodium alginate strand in aqueous solution is hindered, so that the electrostatic spinning of simple sodium alginate is more tired
It is difficult.
Therefore, in the prior art, electrostatic spinning process prepares sodium alginate electro spinning nano fiber, the preparation master of spinning solution
There is following two method:
First method is that a certain amount of additive (such as calcium chloride, glycerol or surface work are added in sodium alginate soln
Property agent etc.), increase the chain entanglement of sodium alginate molecule interchain with this, realizes the electrostatic spinning of sodium alginate.
But the sodium alginate nano fiber that this method obtains contains additive, and can not effectively remove.That is, institute
It not is pure sodium alginate nano fiber truly that sodium alginate nano fiber, which is made,.
Second method is uniformly to mix sodium alginate with the water-soluble high-molecular compound of other good spinnabilities, system
Standby spinning solution out, the spinnability progress for improving sodium alginate by the macromolecule of other spinnabilitys are blended.
But the nanofiber that this method obtains is blended nanofiber, other more macromolecules are contained in inside, and
And it cannot remove.That is, obtained sodium alginate nano fiber is also not pure sodium alginate nano fiber truly.
For these reasons, pure sodium alginate nanometer truly can not be made in the electrostatic spinning process of the prior art
Fiber, this limits the application field of sodium alginate nano fiber to a certain extent.For example, on biological medicine engineering field
Using.
How to carry out sodium alginate-modified and effectively remove additional ingredients introduced in modifying process, and then prepares
Pure sodium alginate nano fiber has become those skilled in the art's technical problem urgently to be resolved.
Summary of the invention
It is controllable, stable product quality based on electrostatic spinning shapes that it is an object of the present invention to provide a kind of simple processes
The preparation method of pure sodium alginate nano fiber, to prepare pure sodium alginate nano fiber.
The technical issues that need to address include two aspects to the present invention to achieve the above object: being on the one hand, how to seaweed
Sour sodium is modified, to improve its spinnability；It on the other hand is the additive ingredient how to contain modified sodium alginate
It is effectively removed before the preparation of spinning solution, to obtain the single sodium alginate pure substance of chemical component.
The present invention is to solve this technical problem the technical scheme adopted is that a kind of pure seaweed based on electrostatic spinning shapes
The preparation method of sour sodium nanofiber, which comprises the following steps:
The first step, the in mass ratio ratio of 0.01-0.05 ︰ 1, weigh sodium metaperiodate and sodium alginate respectively, spare；
Second step, uses deionized water as solvent, and the weighed sodium metaperiodate of institute and sodium alginate are prepared quality respectively
The sodium periodate solution that the sodium alginate soln and mass percent concentration that percent concentration is 0.1-10% are 1%；
Gained sodium periodate solution is added in sodium alginate soln, holds under conditions of room temperature, being protected from light by third step
Continuous stirring 0.5-10h, the oxidation reaction to guarantee sodium metaperiodate and sodium alginate is complete, obtains mixed solution；
Then, the ratio for being 1:1 in the molar ratio of ethylene glycol and sodium metaperiodate is added ethylene glycol as terminator, obtains
High aldehyde sodium alginate solution A；
Enough ethyl alcohol is added into above-mentioned high aldehyde sodium alginate solution A, so that its precipitation reaction is complete in 4th step；
The high aldehyde sodium alginate B of solid content is obtained after being centrifuged off liquid phase ingredient；
The volume of above-mentioned ethyl alcohol is 5 times or more of the volume of high aldehyde sodium alginate solution A；
5th step, by the high aldehyde sodium alginate B deionized water dissolving of gained, being configured to mass percent concentration is 1%-
5% high aldehyde sodium alginate solution C；
Then, the high aldehyde sodium alginate solution C of gained is dialysed several times, until the conductivity of dialyzate no longer becomes
Change, then be freeze-dried to over dry, obtains pure powdered high aldehyde radical alginic acid D；
Above-mentioned dialysis is that molecular cut off is used to carry out for the bag filter of 1000-3600；
6th step takes above-mentioned powdered pure high aldehyde sodium alginate by the requirement of electrostatic spinning process, add from
Sub- water is configured to spinning solution；
Then, gained spinning solution is added in the syringe of electrostatic spinning apparatus, routinely electrostatic spinning shapes technique
Condition sets specific technological parameter, opens device for spinning and carries out electrostatic spinning to get pure sodium alginate nano fiber.
How sodium alginate is modified the technical effect brought directely by the technical proposal is that preferably solving,
To improve its spinnability；And how the additive ingredient that modified sodium alginate contains to be had before electrostatic spinning shapes
Technical problem of both effect removal, and pure sodium alginate nano fiber is prepared using conventional electrostatic spinning process.
The technical principle of above-mentioned technical proposal is as follows:
By the oxidation reaction of sodium metaperiodate and sodium alginate, high aldehyde sodium alginate is obtained, it is whole by the way that ethylene glycol is added
Only oxidation reaction, by controlling different oxidization time, the available high aldehyde sodium alginate with different degree of oxidation；
Then, obtained high aldehyde sodium alginate is precipitated using ethyl alcohol, obtains solid content；Solid content is added again
It dialyses into bag filter, to remove the additives chemical component such as remaining sodium metaperiodate, ethylene glycol and ethyl alcohol, is obtained after dry
To the powder of pure high aldehyde sodium alginate；
On this basis, it is configured to the spinning solution of pure sodium alginate chemical component, electrostatic spinning is carried out and obtains pure sea
Sodium alginate nano fiber.To preferably solve the problems, such as the prior art " pure sodium alginate nano fiber cannot be obtained "
Technical problem.
In above-mentioned technical proposal, sodium alginate is aoxidized using strong oxidizer sodium metaperiodate, obtains modified height
Aldehyde sodium alginate purifies after dialysing.That is, by introducing more aldehyde radicals on sodium alginate strand, to effectively improve
Entanglement degree between sodium alginate strand and sodium alginate strand realizes pure sodium alginate solution from can not spin can spin
Transformation, obtained pure sodium alginate nano fiber.Being made for pure sodium alginate nano fiber, has effectively widened and has cured in biology
The application range of medicine engineering field has highly important significant meaning.
Illustrate: in above-mentioned technical proposal, when " conductivity of dialyzate no longer changes ", showing high aldehyde radical alginic acid at this time
Have become pure sodium alginate ingredient in sodium solution, no longer (additive ingredient is given completely containing additive ingredient
Come).
Preferably, above-mentioned dialysis time is 48h or more.
The direct bring of the optimal technical scheme has the technical effect that, can effectively remove additive ingredient, obtain high-purity
High aldehyde sodium alginate.
(divide the reason is that, the lesser sodium metaperiodate of molecular weight can be precipitated in the bag filter that molecular cut off is 1000-3600
Son amount 214), ethyl alcohol (molecular weight 46) and ethylene glycol (molecular weight 62), and the more aldehyde radical seaweed of macromolecule will not be precipitated in guarantee
Sour sodium (molecular weight is greater than 30,000), therefore high aldehyde sodium alginate can be purified well；And controlling dialysis time is 48h or more,
It can guarantee very ideal dialysis-effect.
Further preferably, the mass percent concentration of above-mentioned spinning solution is 15%-30%.
The direct bring of the optimal technical scheme has the technical effect that, the mass percent concentration control of spinning solution is existed
In the range of 15%-30%, can better ensure that electrostatic spinning shapes go on smoothly and the continuity of spinning technique with
Stability.
The reason is that, the lower entanglement that can reduce sodium alginate of sodium alginate soln concentration, influences electrospinning；Sodium alginate
Solution concentration is excessively high, then the viscosity of spinning solution will be excessively high, influences the extrusion molding of spinning solution, leads to difficulty in spinning, or even can not
Spinning.
Further preferably, the technological temperature of above-mentioned freeze-drying is -65 DEG C or less.
The direct bring of the optimal technical scheme has the technical effect that, because containing ethyl alcohol in the solution, should not adopt
With conventional high temperature dry processes.
- 65 DEG C of freeze drying process temperature below why are selected, are because guaranteeing drying in this way, not only improving
Effect, and can effectively shorten drying time.
Further preferably, above-mentioned technological parameter specifically includes that voltage is 10-25kV, and the distance of spray head to receiver is 5-
25cm, flow 0.1-1ml/h.
The direct bring of the optimal technical scheme has the technical effect that, using these conventional electrostatic spinning process parameters, i.e.,
Electrostatic spinning can be carried out, and obtains the nanofiber continuous, exterior appearance is preferable, of uniform size.Illustrate above-mentioned technical proposal
Technological operation and control it is simple.
Further preferably, it has been additionally added ethyl alcohol in above-mentioned spinning solution, the additional amount of the ethyl alcohol accounts for the hundred of spinning solution gross mass
Divide than being 5%-20%.
The direct bring of the optimal technical scheme has the technical effect that, the ethyl alcohol of aforementioned proportion is added in spinning solution, can be effective
Increase the hydrophobic effect of sodium alginate molecule interchain, and reduce spinning solution conductivity, is more advantageous to going on smoothly for electrostatic spinning；
Also, introduced ethyl alcohol, by natural volatilization in finished fiber, not will lead to product as just the auxiliary agent in spinning process
The reduction of purity.
Detailed description of the invention
Fig. 1 is the schematic diagram that oxidation reaction occurs for sodium alginate and sodium metaperiodate；
Fig. 2 is the stereoscan photograph of nanofiber obtained by embodiment 1；
Fig. 3 is the stereoscan photograph of nanofiber obtained by embodiment 2；
Fig. 4 is the scanning electron microscopic picture of nanofiber obtained by embodiment 3；
Fig. 5 is the scanning electron microscopic picture of nanofiber obtained by embodiment 4.
Specific embodiment
Below with reference to embodiment, the present invention is described in detail.
Illustrate: in following examples, sodium alginate feedstock grade is food-grade (commercially available), remaining each chemical reagent (city
Sell) it is that analysis is pure.
Embodiment 1
The preparation method is as follows:
The first step, in mass ratio 0.01:1 weigh the sodium metaperiodate of 0.05g and the sodium alginate of 5g respectively, spare；
Second step, measure deionized water be used as solvent, respectively prepare sodium alginate mass percent concentration be 10% solution,
The sodium periodate solution that mass percent concentration is 0.1%；
Sodium periodate solution is added in sodium alginate soln by third step under conditions of room temperature, being protected from light, and is persistently stirred
3h is mixed, the oxidation reaction to guarantee sodium metaperiodate and sodium alginate is complete, obtains mixed solution；
Then, ethylene glycol is added as terminator in the ratio that the molar ratio of ethylene glycol and sodium metaperiodate is 1:1 to obtain
High aldehyde sodium alginate solution；
The ethyl alcohol of 500ml is added in 4th step, and high aldehyde sodium alginate solid content is obtained after centrifugation；
100ml deionized water is added in 5th step, by the high aldehyde sodium alginate solid content dissolution of gained, is configured to quality hundred
Dividing specific concentration is 5% solution；
Then, selecting molecular cut off is that 1000 bag filter carries out dialysis 72h, until the conductivity of dialyzate no longer becomes
Change；
Later, the solution after dialysis is freeze-dried at -65 DEG C to over dry, obtains powdered pure high aldehyde radical seaweed
Sour sodium；
6th step, the routinely requirement of electrostatic spinning process, then by the high aldehyde sodium alginate powder stirring point of 20.0g
Dissipate in 70ml water in, stir 1h or more, 10g ethanol solution is slowly added dropwise, be made mass percent concentration be 20% more aldehyde
Base sodium alginate spinning solution；
Spinning solution is added in syringe, adjusting voltage is 25kV, and the distance of spray head to receiver is 15cm, flow
For 0.5ml/h；Device for spinning is opened, the conditions such as temperature, the humidity in device are controlled, transformer is opened and carries out electrospinning, with table
The smooth masking foil in face be reception device to get arrive pure sodium alginate nano fiber.
Embodiment 2
The preparation method is as follows:
The first step, in mass ratio 0.1:1 weigh the sodium metaperiodate of 0.3g and the sodium alginate of 3g respectively, spare；
Second step, measure deionized water be used as solvent, respectively prepare sodium alginate mass percent concentration be 6% solution,
The sodium periodate solution that mass percent concentration is 0.3%；
Sodium periodate solution is added in sodium alginate soln by third step under conditions of room temperature, being protected from light, and is persistently stirred
5h is mixed, the oxidation reaction to guarantee sodium metaperiodate and sodium alginate is complete, obtains mixed solution；
Then, it is 1:1 ratio addition ethylene glycol as terminator in the molar ratio of ethylene glycol and sodium metaperiodate and obtains height
Aldehyde sodium alginate solution；
The ethyl alcohol of 500ml is added in 4th step, and high aldehyde sodium alginate solid content is obtained after centrifugation；
100ml deionized water is added in 5th step, by the high aldehyde sodium alginate solid content dissolution of gained, is configured to quality hundred
Dividing specific concentration is 3% solution；
Then, selecting molecular cut off is that 2000 bag filter carries out dialysis 60h, until the conductivity of dialyzate no longer becomes
Change；
Later, the solution after dialysis is freeze-dried at -65 DEG C to over dry, obtains powdered pure high aldehyde radical seaweed
Sour sodium；
6th step, by the requirement of spinning technique, then by 25.0 high aldehyde sodium alginate powder be dispersed with stirring in
In 65ml water, 1h or more is stirred, 10g ethanol solution is slowly added dropwise, more aldehyde radical seaweed that mass percent concentration is 25% are made
Sour sodium spinning solution；
Spinning solution is added in syringe, adjusting voltage is 20kV, and the distance of spray head to receiver is 15cm, flow
For 0.5ml/h；Device for spinning is opened, pure sodium alginate nano fiber can be obtained on collection device.
Embodiment 3
The preparation method is as follows:
The first step, in mass ratio 0.05:1 weigh the sodium metaperiodate of 0.1g and the sodium alginate of 2g respectively, spare；
Second step, measure deionized water be used as solvent, respectively prepare sodium alginate mass percent concentration be 4% solution,
The sodium periodate solution that mass percent concentration is 0.2%；
Sodium periodate solution is added in sodium alginate soln by third step under conditions of room temperature, being protected from light, and is persistently stirred
2.5h is mixed, the oxidation reaction to guarantee sodium metaperiodate and sodium alginate is complete, obtains mixed solution；
Then, ethylene glycol is added as terminator in the ratio that the molar ratio of ethylene glycol and sodium metaperiodate is 1:1 to obtain
High aldehyde sodium alginate solution；
The ethyl alcohol of 500ml is added in 4th step, and high aldehyde sodium alginate solid content is obtained after centrifugation；
100ml deionized water is added in 5th step, by the high aldehyde sodium alginate solid content dissolution of gained, is configured to quality hundred
Dividing specific concentration is 1% solution；
Then, selecting molecular cut off is that 3600 bag filter carries out dialysis 48h, until the conductivity of dialyzate no longer becomes
Change；
Later, the solution after dialysis is freeze-dried at -65 DEG C to over dry, obtains powdered pure high aldehyde radical seaweed
Sour sodium；
6th step, by the requirement of spinning technique, then by the high aldehyde sodium alginate powder of 15g be dispersed with stirring in 75ml
In water, 1h or more is stirred, 10g ethanol solution is slowly added dropwise, more aldehyde sodium alginates that mass percent concentration is 15% are made
Spinning solution；
Above-mentioned spinning solution is added in syringe, adjusting voltage is 25kV, and the distance of spray head to receiver is 10cm,
Flow is 0.1ml/h；Device for spinning is opened, pure sodium alginate nano fiber can be obtained on collection device.
Embodiment 4
The preparation method is as follows:
The first step, in mass ratio 0.25:1 weigh the sodium metaperiodate of 1g and the sodium alginate of 4g respectively, spare；
Second step measures deionized water as solvent, it is molten to prepare the sodium alginate that mass percent concentration is 8% respectively
Liquid, the sodium periodate solution that mass percent concentration is 2%；
Sodium periodate solution is added in sodium alginate soln by third step under conditions of room temperature, being protected from light, and is persistently stirred
6.5h is mixed, the oxidation reaction to guarantee sodium metaperiodate and sodium alginate is complete, obtains mixed solution；
Then, ethylene glycol is added as terminator in the ratio that the molar ratio of ethylene glycol and sodium metaperiodate is 1:1 to obtain
High aldehyde sodium alginate solution；
The ethyl alcohol of 500ml is added in 4th step, and high aldehyde sodium alginate solid content is obtained after centrifugation；
100ml deionized water is added in 5th step, by the high aldehyde sodium alginate solid content dissolution of gained, is configured to quality hundred
Dividing specific concentration is 4% solution；
Then, selecting molecular cut off is that 3600 bag filter carries out dialysis 48h, until the conductivity of dialyzate no longer becomes
Change；
Later, the solution after dialysis is freeze-dried at -65 DEG C to over dry, obtains powdered pure high aldehyde radical seaweed
Sour sodium；
6th step, by the requirement of spinning technique, then by the high aldehyde sodium alginate powder of 30g be dispersed with stirring in 55ml
In water, 1h or more is stirred, 15g ethanol solution is slowly added dropwise, more aldehyde sodium alginates that mass percent concentration is 30% are made
Spinning solution；
Above-mentioned spinning solution is added in syringe, adjusting voltage is 30kV, and the distance of spray head to receiver is 20cm,
Flow is 0.6ml/h；
Device for spinning is opened, pure sodium alginate nano fiber is obtained on collection device.
The detection and inspection of product:
The resulting fiber product of embodiment 1 to 4 is observed under Electronic Speculum respectively, as a result respectively as shown in Fig. 2 to 5.
It can be seen that gained fiber from Fig. 2 to Fig. 5 and all have apparent nano structure, show that obtained product is sodium alginate
Nanofiber.
Illustrate:
Main chemical reactions mechanism of the invention as shown in Figure 1, sodium alginate under the action of strong oxidizer sodium metaperiodate
It is oxidized, the saccharide ring open loop on sodium alginate strand simultaneously introduces large number of aldehyde radical.
This will be effectively improved in (following) spinning solution, twining between sodium alginate strand and sodium alginate strand
Knot degree reaches electrostatic spinning process requirement.
Claims (3)
1. a kind of preparation method of the pure sodium alginate nano fiber based on electrostatic spinning shapes, which is characterized in that including following
Step:
The first step, the in mass ratio ratio of 0.01-0.05 ︰ 1, weigh sodium metaperiodate and sodium alginate respectively, spare；
Second step, uses deionized water as solvent, and the weighed sodium metaperiodate of institute and sodium alginate are prepared quality percentage respectively
The sodium periodate solution that the sodium alginate soln and mass percent concentration that specific concentration is 0.1-10% are 1%；
Gained sodium periodate solution is added in sodium alginate soln, persistently stirs under conditions of room temperature, being protected from light by third step
3-10h is mixed, the oxidation reaction to guarantee sodium metaperiodate and sodium alginate is complete, obtains mixed solution；
Then, the ratio for being 1:1 in the molar ratio of ethylene glycol and sodium metaperiodate is added ethylene glycol as terminator, obtains high aldehyde
Base sodium alginate soln A；
Enough ethyl alcohol is added into above-mentioned high aldehyde sodium alginate solution A, so that its precipitation reaction is complete in 4th step；Centrifugation
The high aldehyde sodium alginate B of solid content is obtained after removing liquid phase ingredient；
The volume of above-mentioned ethyl alcohol is 5 times or more of the volume of high aldehyde sodium alginate solution A；
5th step, by the high aldehyde sodium alginate B deionized water dissolving of gained, being configured to mass percent concentration is 1%-5%
High aldehyde sodium alginate solution C；
Then, the high aldehyde sodium alginate solution C of gained is dialysed several times, until the conductivity of dialyzate no longer changes,
It is freeze-dried again to over dry, obtains pure powdered high aldehyde sodium alginate D, the dialysis time is 48h or more；
Above-mentioned dialysis is that molecular cut off is used to carry out for the bag filter of 1000-3600；
6th step takes above-mentioned powdered pure high aldehyde sodium alginate by the requirement of electrostatic spinning process, be scattered in from
In sub- water, stirring is slowly added dropwise ethyl alcohol, is configured to spinning solution；
Then, gained spinning solution is added in the syringe of electrostatic spinning apparatus, routinely electrostatic spinning shapes process conditions
Specific technological parameter is set, device for spinning is opened and carries out electrostatic spinning to get pure sodium alginate nano fiber；The spinning
The mass percent concentration of liquid is 15%-30%；It is additionally added ethyl alcohol in the spinning solution, the additional amount of the ethyl alcohol accounts for spinning solution
The percentage of gross mass is 5%-20%.
2. the preparation method of the pure sodium alginate nano fiber according to claim 1 based on electrostatic spinning shapes, special
Sign is that the technological temperature of the freeze-drying is -65 DEG C or less.
3. the preparation method of the pure sodium alginate nano fiber according to claim 1 or 2 based on electrostatic spinning shapes,
It is characterized in that, the technological parameter specifically includes that voltage is 10-25kV, and the distance of spray head to receiver is 5-25cm, and flow is
0.1-1ml/h。
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