CN106581738A - Superabsorbent medical composite haemostasis sponge and preparation method thereof - Google Patents
Superabsorbent medical composite haemostasis sponge and preparation method thereof Download PDFInfo
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- CN106581738A CN106581738A CN201611127063.9A CN201611127063A CN106581738A CN 106581738 A CN106581738 A CN 106581738A CN 201611127063 A CN201611127063 A CN 201611127063A CN 106581738 A CN106581738 A CN 106581738A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0042—Fibrin; Fibrinogen
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention discloses a superabsorbent medical composite haemostasis sponge and a preparation method thereof. The haemostasis sponge comprises the raw materials: alginate, fibrin glue, sephadex gel, polyuronide hemicelluloses, hyaluronan, gluconic acid strontium, iron-dextrin, epigallocatechin, 5-methoxy-N,N-diisopropyltryptamine, mint alkyl diamine, eucalyptole, puffball powder, a cross-linking agent, tween-60, ethanol 2, and distilled water. The liquid absorbing capability of the medical composite haemostasis sponge is strong, haemostasis time is short, effect is good, invasion of an extraneous substance can be isolated, wound healing is promoted, and the superabsorbent medical composite haemostasis sponge can be widely used for haemostasis and restoration of burn, wound, and surgical operation wound, and has good application value.
Description
Technical field
The invention belongs to medical material tech field, and in particular to a kind of super absorbent medical compound hemostatic sponge and its preparation
Method.
Background technology
Hemostasis is a complicated process, in addition to blood itself solidifies, pressure and other antihemorrhagic factors that outside gives
Bleeding stopping period can also be shortened, promote wound healing.Good hemostatic material in medical use not only need to have common bleeding stopping period it is short,
Haemostatic effect is good, can not increase the characteristics such as the infection of wound, and should not produce secondary insult, should also to material implanted
With good biocompatibility, no antigen, degradable, and good with the adhesiveness of tissue are coincide with wound, wound surface place site
Property the characteristic such as good, while also with repairing, the multi-functional such as treatment.Existing common hemostatic material mainly has:Sthptic sponge, only
The products such as blood gauze, hemostasis gel, stanch fibre, tourniquet bandage, hemostatic micropowder, chitosan film and Fibrin Glue.Wherein, only
Sea of blood silk floss common are collagen protein sponge, gelfoam and chitosan sponge etc., and which has extraordinary water absorption and swollen
Swollen property, sponge can be expanded rapidly and oppress and block petechia after absorbing the moisture in blood, while can accelerate hematoblastic solidifying
It is poly-, promote blood coagulation;The pore passage structure of sponge is also beneficial to oxygen and carbon dioxide passes through, and is that wound healing creates good ring
Border.But the haemostatic effect and mechanical strength of the reality of existing sthptic sponge need further to improve.
The content of the invention
For this purpose, the present invention provides a kind of super absorbent medical compound hemostatic sponge and preparation method thereof, solve in prior art
The haemostatic effect and mechanical strength of the reality of existing sthptic sponge need the deficiency for further improving.
For this purpose, the present invention provides super absorbent medical compound hemostatic sponge, in parts by weight, it is prepared from the following materials:
Alginate 19-30 parts, Fibrin Glue 10-21 parts, sephadex 5-12 parts, poly alduronic acid hemicellulose 3-9
Part, hyaluronan 4-8 parts, gluconic acid strontium 1-4 parts, iron dextran 0.5-2 parts, epigallo catechin 1.2-3.6 parts, 5-
Methoxyl group-N, N- diisopropyl tryptamines 0.8-2.4 parts, terpane diamidogen 0.6-1.8 parts, eucalyptol 0.4-1.3 parts, Lasiosphaera Seu Calvatia powder
0.8-2 parts, cross-linking agent 0.5-2.6 parts, Tween-60 1.5-3 parts, ethanol 25-38 parts, distilled water 60-80 parts.
An embodiment of the invention, wherein, the cross-linking agent is citric acid, sodium diacetate, iron chloride, poly- second
The mixture of enol and sodium trimetaphosphate.
An embodiment of the invention, wherein, it is 1 that the cross-linking agent is weight ratio:0.5:1.2:0.9:2.7
The mixture of citric acid, sodium diacetate, iron chloride, polyvinyl alcohol and sodium trimetaphosphate.
An embodiment of the invention, wherein, the alginate is sodium alginate, ammonium alginate, alginic acid
Potassium or alginic acid magnesium.
An embodiment of the invention, wherein, in parts by weight, it is prepared from the following materials:Alginate
21-28 parts, Fibrin Glue 11-20 parts, sephadex 5.7-9 parts, poly alduronic acid hemicellulose 3.4-8.6 parts,
Hyaluronan 4.5-7 parts, gluconic acid strontium 1.6-3.5 parts, iron dextran 0.7-1.6 parts, epigallo catechin 1.4-3.3
Part, 5- methoxyl group-N, N- diisopropyl tryptamines 0.9-2.1 parts, terpane diamidogen 0.8-1.4 parts, eucalyptol 0.6-1.1 parts, horse
Vigorous powder 1.1-1.8 parts, cross-linking agent 0.7-2.4 parts, Tween-60 1.7-2.6 parts, ethanol 28-35 parts, distilled water 64-78 parts.
For this purpose, the present invention provides the preparation method of super absorbent medical compound hemostatic sponge, the preparation method includes following
Step:
(1)By weight, weigh raw material:Alginate 19-28 parts, Fibrin Glue 10-21 parts, sephadex 5-12
Part, poly alduronic acid hemicellulose 3-9 parts, hyaluronan 4-8 parts, gluconic acid strontium 1-4 parts, iron dextran 0.5-2 parts, table
Nutgall catechin 1.2-3.6 parts, 5- methoxyl group-N, N- diisopropyl tryptamines 0.8-2.4 parts, terpane diamidogen 0.6-1.8 parts,
Eucalyptol 0.4-1.3 parts, Lasiosphaera Seu Calvatia powder 0.8-2 parts, cross-linking agent 0.5-2.6 parts, Tween-60 1.5-3 parts, ethanol 25-38 parts, steaming
Distilled water 60-80 part;
(2)Alginate and Fibrin Glue are added in distilled water, mix homogeneously, regulation pH value of solution are 8-10, are then heated
Stirring 20-60 minutes, Lasiosphaera Seu Calvatia powder, iron dextran and gluconic acid strontium are added afterwards, continues stirring 20-60 minutes;
(3)Sephadex, poly alduronic acid hemicellulose and hyaluronan are added in ethanol, 40-60 DEG C is heated to,
Room temperature is down to after stirring 4-8 hours, Tween-60, epigallo catechin, eucalyptol, 5- methoxyl group-N, N- bis- is sequentially added
Isopropyl tryptamines and terpane diamidogen, stir 30-60 minutes;
(4)By step(3)Obtained mixed liquor adds step(2)In, stir, be subsequently adding cross-linking agent, with 50-100rpm
Speed stirring 50-80 minutes;
(5)By step(4)Obtained mixed liquor is poured in mould, is then soaked in 5 hours in 2wt.% Klorvess Liquids, is taken out
And lyophilization, and scrubbed drying, sterilizing, obtain final product.
Beneficial effects of the present invention are:
The imbibition ability of medical compound hemostatic sponge prepared by the present invention is strong, liquid absorbency rate up to 29 and its more than, bleeding stopping period
It is short and effect is good, can in the 30s only venous hemorrhage, stop arterial hemorrhage in 200s, and its tensile strength reach 218.6-
225.6KPa, can completely cut off the invasion of external substance, and wound healing can be widely applied to burn, wound, surgical operation wound
The hemostasis and reparation of mouth, with good using value.
Specific embodiment
With reference to embodiment, the present invention is described in further detail.Following examples are used to illustrate the present invention, but not
For limiting the scope of the present invention.
Embodiment 1
A kind of preparation method of super absorbent medical compound hemostatic sponge, the preparation method are comprised the following steps:
(1)By weight, weigh raw material:19 parts of alginate, 10 parts of Fibrin Glue, 5 parts of sephadex, polysaccharide
3 parts of aldehydic acid hemicellulose, 4 parts of hyaluronan, 1 part of gluconic acid strontium, 0.5 part of iron dextran, epigallo catechin 1.2
Part, 5- methoxyl group-N, 0.8 part of N- diisopropyls tryptamines, 0.6 part of terpane diamidogen, 0.4 part of eucalyptol, 0.8 part of Lasiosphaera Seu Calvatia powder, friendship
0.5 part of agent of connection, 1.5 parts of Tween-60,25 parts of ethanol, 60 parts of distilled water;It is 1 that the cross-linking agent is weight ratio:1.3:1.2:
1.5:The mixture of 3 citric acid, sodium diacetate, iron chloride, polyvinyl alcohol and sodium trimetaphosphate;The alginate is Sargassum
Sour sodium;
(2)Alginate and Fibrin Glue are added in distilled water, mix homogeneously, it is 8 to adjust pH value of solution, then heated and stirred
20 minutes, Lasiosphaera Seu Calvatia powder, iron dextran and gluconic acid strontium are added afterwards, continues stirring 20 minutes;
(3)Sephadex, poly alduronic acid hemicellulose and hyaluronan are added in ethanol, 40 DEG C is heated to, is stirred
Room temperature is down to after mixing 4 hours, Tween-60, epigallo catechin, eucalyptol, 5- methoxyl group-N, N- diisopropyls is sequentially added
Primary colours amine and terpane diamidogen, stir 30 minutes;
(4)By step(3)Obtained mixed liquor adds step(2)In, stir, be subsequently adding cross-linking agent, with the speed of 50rpm
Degree stirring 50 minutes;
(5)By step(4)Obtained mixed liquor is poured in mould, is then soaked in 5 hours in 2wt.% Klorvess Liquids, is taken out
And lyophilization, and scrubbed drying, sterilizing, obtain final product.
Embodiment 2
A kind of preparation method of super absorbent medical compound hemostatic sponge, the preparation method are comprised the following steps:
(1)By weight, weigh raw material:28 parts of alginate, 21 parts of Fibrin Glue, 12 parts of sephadex, poly
9 parts of alduronic acid hemicellulose, 8 parts of hyaluronan, 4 parts of gluconic acid strontium, 2 parts of iron dextran, epigallo catechin 3.6
Part, 5- methoxyl group-N, 2.4 parts of N- diisopropyls tryptamines, 1.8 parts of terpane diamidogen, 1.3 parts of eucalyptol, 2 parts of Lasiosphaera Seu Calvatia powder, crosslinking
2.6 parts of agent, 3 parts of Tween-60,38 parts of ethanol, 80 parts of distilled water;It is 1 that the cross-linking agent is weight ratio:0.5:1.2:0.9:2.7
Citric acid, sodium diacetate, iron chloride, the mixture of polyvinyl alcohol and sodium trimetaphosphate;The alginate is ammonium alginate;
(2)Alginate and Fibrin Glue are added in distilled water, mix homogeneously, it is 10 to adjust pH value of solution, and then heating is stirred
Mix 60 minutes, add Lasiosphaera Seu Calvatia powder, iron dextran and gluconic acid strontium afterwards, continue stirring 60 minutes;
(3)Sephadex, poly alduronic acid hemicellulose and hyaluronan are added in ethanol, 60 DEG C is heated to, is stirred
Room temperature is down to after mixing 8 hours, Tween-60, epigallo catechin, eucalyptol, 5- methoxyl group-N, N- diisopropyls is sequentially added
Primary colours amine and terpane diamidogen, stir 60 minutes;
(4)By step(3)Obtained mixed liquor adds step(2)In, stir, be subsequently adding cross-linking agent, with 100rpm's
Speed is stirred 80 minutes;
(5)By step(4)Obtained mixed liquor is poured in mould, is then soaked in 5 hours in 2wt.% Klorvess Liquids, is taken out
And lyophilization, and scrubbed drying, sterilizing, obtain final product.
Embodiment 3
A kind of preparation method of super absorbent medical compound hemostatic sponge, the preparation method are comprised the following steps:
(1)By weight, weigh raw material:21 parts of alginate, 11 parts of Fibrin Glue, 5.7 parts of sephadex, poly
3.4 parts of alduronic acid hemicellulose, 4.5 parts of hyaluronan, 1.6 parts of gluconic acid strontium, 0.7 part of iron dextran, epigallocatechin gallate
1.4 parts of theine, 5- methoxyl group-N, 0.9 part of N- diisopropyls tryptamines, 0.8 part of terpane diamidogen, 0.6 part of eucalyptol, Lasiosphaera Seu Calvatia powder
1.1 parts, 0.7 part of cross-linking agent, 1.7 parts of Tween-60,28 parts of ethanol, 64 parts of distilled water;It is 1 that the cross-linking agent is weight ratio:
0.8:1.5:1.8:The mixture of 3.2 citric acid, sodium diacetate, iron chloride, polyvinyl alcohol and sodium trimetaphosphate;The Sargassum
Hydrochlorate is potassium alginate;
(2)Alginate and Fibrin Glue are added in distilled water, mix homogeneously, it is 9 to adjust pH value of solution, then heated and stirred
40 minutes, Lasiosphaera Seu Calvatia powder, iron dextran and gluconic acid strontium are added afterwards, continues stirring 50 minutes;
(3)Sephadex, poly alduronic acid hemicellulose and hyaluronan are added in ethanol, 50 DEG C is heated to, is stirred
Room temperature is down to after mixing 6 hours, Tween-60, epigallo catechin, eucalyptol, 5- methoxyl group-N, N- diisopropyls is sequentially added
Primary colours amine and terpane diamidogen, stir 45 minutes;
(4)By step(3)Obtained mixed liquor adds step(2)In, stir, be subsequently adding cross-linking agent, with the speed of 80rpm
Degree stirring 60 minutes;
(5)By step(4)Obtained mixed liquor is poured in mould, is then soaked in 5 hours in 2wt.% Klorvess Liquids, is taken out
And lyophilization, and scrubbed drying, sterilizing, obtain final product.
Embodiment 4
A kind of preparation method of super absorbent medical compound hemostatic sponge, the preparation method are comprised the following steps:
(1)By weight, weigh raw material:28 parts of alginate, 20 parts of Fibrin Glue, 9 parts of sephadex, polysaccharide
8.6 parts of aldehydic acid hemicellulose, 7 parts of hyaluronan, 3.5 parts of gluconic acid strontium, 1.6 parts of iron dextran, epigallo catechin
3.3 parts, 5- methoxyl group-N, 2.1 parts of N- diisopropyls tryptamines, 1.4 parts of terpane diamidogen, 1.1 parts of eucalyptol, 1.8 parts of Lasiosphaera Seu Calvatia powder,
2.4 parts of cross-linking agent, 2.6 parts of Tween-60,35 parts of ethanol, 78 parts of distilled water;It is 1 that the cross-linking agent is weight ratio:0.8:1.5:
1.8:The mixture of 3.2 citric acid, sodium diacetate, iron chloride, polyvinyl alcohol and sodium trimetaphosphate;The alginate is sea
Alginic acid magnesium;
(2)Alginate and Fibrin Glue are added in distilled water, mix homogeneously, it is 9.5 to adjust pH value of solution, and then heating is stirred
Mix 30 minutes, add Lasiosphaera Seu Calvatia powder, iron dextran and gluconic acid strontium afterwards, continue stirring 45 minutes;
(3)Sephadex, poly alduronic acid hemicellulose and hyaluronan are added in ethanol, 60 DEG C is heated to, is stirred
Room temperature is down to after mixing 8 hours, Tween-60, epigallo catechin, eucalyptol, 5- methoxyl group-N, N- diisopropyls is sequentially added
Primary colours amine and terpane diamidogen, stir 50 minutes;
(4)By step(3)Obtained mixed liquor adds step(2)In, stir, be subsequently adding cross-linking agent, with the speed of 90rpm
Degree stirring 70 minutes;
(5)By step(4)Obtained mixed liquor is poured in mould, is then soaked in 5 hours in 2wt.% Klorvess Liquids, is taken out
And lyophilization, and scrubbed drying, sterilizing, obtain final product.
Comparative example 1
In place of this comparative example and the difference of embodiment 1 it is:Without gluconic acid strontium, 5- methoxyl group-N, N- diisopropyl tryptamines
With poly alduronic acid hemicellulose.
Comparative example 2
In place of this comparative example and the difference of embodiment 1 it is:Without Lasiosphaera Seu Calvatia powder, iron dextran and eucalyptol.
Comparative example 3
In place of this comparative example and the difference of embodiment 1 it is:The cross-linking agent is sodium diacetate.
Properties of product are tested
Above-mentioned sponge products are cut into into the sample size of 1 × 1cm, and the testing standard according to this area carries out following performance survey
Try, its test result is:
Bleeding stopping period/s(Venous hemorrhage) | Bleeding stopping period/s(Arterial hemorrhage) | Liquid absorbency rate | Tensile strength/KPa | |
Embodiment 1 | 25±5 | 180±20 | 29 | 218.6 |
Embodiment 2 | 23±5 | 175±20 | 31 | 216.3 |
Embodiment 3 | 22±5 | 171±20 | 32 | 223.8 |
Embodiment 4 | 20±3 | 166±20 | 34 | 225.6 |
Comparative example 1 | 40±10 | 210±20 | 27 | 217.3 |
Comparative example 2 | 38±5 | 220±20 | 26 | 215.3 |
Comparative example 3 | 35±5 | 195±20 | 22 | 217.2 |
The imbibition ability of medical compound hemostatic sponge prepared by the present invention is strong, liquid absorbency rate up to 29 and its more than, bleeding stopping period
It is short and effect is good, can in the 30s only venous hemorrhage, stop arterial hemorrhage in 200s, and its tensile strength reach 218.6-
225.6KPa, can completely cut off the invasion of external substance, and wound healing can be widely applied to burn, wound, surgical operation wound
The hemostasis and reparation of mouth, with good using value.
Claims (6)
1. absorbent medical compound hemostatic sponge is surpassed, it is characterised in that in parts by weight, be prepared from the following materials:Alginic acid
It is salt 19-30 parts, Fibrin Glue 10-21 parts, sephadex 5-12 parts, poly alduronic acid hemicellulose 3-9 parts, transparent
Matter alkane 4-8 parts, gluconic acid strontium 1-4 parts, iron dextran 0.5-2 parts, epigallo catechin 1.2-3.6 parts, 5- methoxyl groups-
N, N- diisopropyl tryptamines 0.8-2.4 parts, terpane diamidogen 0.6-1.8 parts, eucalyptol 0.4-1.3 parts, Lasiosphaera Seu Calvatia powder 0.8-2 parts,
Cross-linking agent 0.5-2.6 parts, Tween-60 1.5-3 parts, ethanol 25-38 parts, distilled water 60-80 parts.
2. super absorbent medical compound hemostatic sponge according to claim 1, it is characterised in that the cross-linking agent is Fructus Citri Limoniae
The mixture of acid, sodium diacetate, iron chloride, polyvinyl alcohol and sodium trimetaphosphate.
3. super absorbent medical compound hemostatic sponge according to claim 1, it is characterised in that the cross-linking agent is weight ratio
For 1:0.5:1.2:0.9:The mixture of 2.7 citric acid, sodium diacetate, iron chloride, polyvinyl alcohol and sodium trimetaphosphate.
4. super absorbent medical compound hemostatic sponge according to claim 1, it is characterised in that the alginate is Sargassum
Sour sodium, ammonium alginate, potassium alginate or alginic acid magnesium.
5. super absorbent medical compound hemostatic sponge according to claim 1, it is characterised in that in parts by weight, by following
Raw material is prepared from:Alginate 21-28 parts, Fibrin Glue 11-20 parts, sephadex 5.7-9 parts, poly alditol
Sour hemicellulose 3.4-8.6 parts, hyaluronan 4.5-7 parts, gluconic acid strontium 1.6-3.5 parts, iron dextran 0.7-1.6 parts,
Epigallo catechin 1.4-3.3 parts, 5- methoxyl group-N, N- diisopropyl tryptamines 0.9-2.1 parts, terpane diamidogen 0.8-1.4
Part, eucalyptol 0.6-1.1 parts, Lasiosphaera Seu Calvatia powder 1.1-1.8 parts, cross-linking agent 0.7-2.4 parts, Tween-60 1.7-2.6 parts, ethanol 28-
35 parts, distilled water 64-78 parts.
6. the preparation method of absorbent medical compound hemostatic sponge is surpassed, it is characterised in that the preparation method is comprised the following steps:
(1)By weight, weigh raw material:Alginate 19-28 parts, Fibrin Glue 10-21 parts, sephadex 5-12
Part, poly alduronic acid hemicellulose 3-9 parts, hyaluronan 4-8 parts, gluconic acid strontium 1-4 parts, iron dextran 0.5-2 parts, table
Nutgall catechin 1.2-3.6 parts, 5- methoxyl group-N, N- diisopropyl tryptamines 0.8-2.4 parts, terpane diamidogen 0.6-1.8 parts,
Eucalyptol 0.4-1.3 parts, Lasiosphaera Seu Calvatia powder 0.8-2 parts, cross-linking agent 0.5-2.6 parts, Tween-60 1.5-3 parts, ethanol 25-38 parts, steaming
Distilled water 60-80 part;
(2)Alginate and Fibrin Glue are added in distilled water, mix homogeneously, regulation pH value of solution are 8-10, are then heated
Stirring 20-60 minutes, Lasiosphaera Seu Calvatia powder, iron dextran and gluconic acid strontium are added afterwards, continues stirring 20-60 minutes;
(3)Sephadex, poly alduronic acid hemicellulose and hyaluronan are added in ethanol, 40-60 DEG C is heated to,
Room temperature is down to after stirring 4-8 hours, Tween-60, epigallo catechin, eucalyptol, 5- methoxyl group-N, N- bis- is sequentially added
Isopropyl tryptamines and terpane diamidogen, stir 30-60 minutes;
(4)By step(3)Obtained mixed liquor adds step(2)In, stir, be subsequently adding cross-linking agent, with 50-100rpm
Speed stirring 50-80 minutes;
(5)By step(4)Obtained mixed liquor is poured in mould, is then soaked in 5 hours in 2wt.% Klorvess Liquids, is taken out
And lyophilization, and scrubbed drying, sterilizing, obtain final product.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107308487A (en) * | 2017-05-31 | 2017-11-03 | 太仓卡斯特姆新材料有限公司 | A kind of medical compound hemostatic sponge of biodegradable high water absorption and preparation method thereof |
CN111867641A (en) * | 2017-11-28 | 2020-10-30 | 巴克斯特国际公司 | Absorbent for treating wound |
-
2016
- 2016-12-09 CN CN201611127063.9A patent/CN106581738A/en not_active Withdrawn
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107308487A (en) * | 2017-05-31 | 2017-11-03 | 太仓卡斯特姆新材料有限公司 | A kind of medical compound hemostatic sponge of biodegradable high water absorption and preparation method thereof |
CN111867641A (en) * | 2017-11-28 | 2020-10-30 | 巴克斯特国际公司 | Absorbent for treating wound |
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