CN106581469A - Traditional Chinese medicine prescription for treating gastric ulcer - Google Patents
Traditional Chinese medicine prescription for treating gastric ulcer Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine prescription for treating gastric ulcer. The traditional Chinese medicine prescription consists of the following components in parts by weight: 12-16 parts of fructus aurantii, 12-20 parts of lignum santali albi, 15-19 parts of bighead atractylodes rhizome, 10-12 parts of radix asparagi, 10-15 parts of rhizoma pinelliae, 10-16 parts of rough melic herb, 6-12 parts of radix aucklandiae, 6-10 parts of clove, 12-16 parts of rhizoma dioscoreae, 10-18 parts of radix cyathulae, 12-16 parts of myrrh and 8-14 parts of rhizoma acori calami. The traditional Chinese medicine provided by the invention has the beneficial effects that the traditional Chinese medicine, on the basis of recognition of the symptoms and mechanism of gastric ulcer and treatment principle, the traditional Chinese medicine adopts an approach of direct oral administration so as to achieve tonification and purgation in combination; the traditional Chinese medicine has effects of strengthening and tonifying spleen and stomach, promoting blood circulation and removing stasis, tonifying qi and nourishing stomach; and the traditional Chinese medicine is significant in curative effect, easy for quality control, good in stability and basically free from adverse reactions.
Description
Technical field
The present invention relates to the field of Chinese medicines, is a kind of Chinese medicine formula that can treat gastric ulcer specifically.
Background technology
Gastric ulcer is a kind of clinical most commonly seen digestive system disease, and patient is mainly shown as that epigastrium is chronic, rule
Property pain.The generation of gastric ulcer and heredity, life（Long-term alcohol or to take nonsteroidal antiinflammatory drug, diet irregular）, spirit
Factor（Psychentonia, anxiety）Relevant, in recent years, research shows, helicobacter pylori infections are that the important of gastric ulcer generation is caused a disease
Reason, therefore, when gastric ulcer is treated, Helicobacter pylori Infection is also key.Gastric ulcer easily recurs, and the course of disease is long, to trouble
The quality of life of person causes serious impact.And easily there are various complication, such as gastric perforation, gastric cancer in gastric ulcer PD
Deng.With the quickening of people's rhythm of life, people's chronic dietary is irregular, psychentonia, overworked, causes gastric ulcer
Sickness rate rises year by year, it has also become one of important diseases of serious harm human health.
According to the pathogenic factor and characteristics of incidence of gastric ulcer, the key agents of the western medical treatment of current gastric ulcer are including antiacid
Agent（Sodium bicarbonate, sodium hydroxide）, proton pump inhibitor（Omeprazole, lansoprazole etc.）, H2 receptor blocking agent（Sago is replaced
Fourth, ranitidine, Famotidine etc.）, gastric mucosa protective agent（Misoprostol etc.）, anti-helicobacter pylori class medicine（Metronidazole
Deng）, but western medical treatment has therapeutic effect undesirable, large side effects, the shortcoming for easily recurring.The traditional Chinese medical science thinks, Mechanism of Gastric Ulcer
Basic factor is weakness of the spleen and stomach, and the important pathology link of morbidity is stagnant heat, shows as simulataneous insufficiency and excessive, cold and heat patients w ith peptic ulcer disease wrong more
It is miscellaneous.In recent years, for the Chinese traditional treatment of gastric ulcer also gradually causes the concern and attention of people, also occur in that on market more
The Chinese medicine preparation for the treatment of gastric ulcer, the such as Radix Astragali build middle ball, Chaihushugan Pill, WEIDE peace capsule, but these Chinese medicine ingredients are complicated,
Patient can cause untoward reaction after long-term taking, still
The content of the invention
It is an object of the invention to provide a kind of evident in efficacy, instant effect, can treating in gastric ulcer of having no side effect
Medicine composition.
The present invention is achieved through the following technical solutions：A kind of Chinese medicine formula that can treat gastric ulcer, including by weight
12 ~ 16 parts of Fructus Aurantii, 12 ~ 20 parts of Lignum Santali Albi, 15 ~ 19 parts of the Rhizoma Atractylodis Macrocephalae, 10 ~ 12 parts of Radix Asparagi, 10 ~ 15 parts of the Rhizoma Pinelliae, 10 ~ 16 parts of Herba Melicae Scabrosae,
6 ~ 12 parts of the Radix Aucklandiae, 6 ~ 10 parts of Flos Caryophylli, 12 ~ 16 parts of Rhizoma Dioscoreae, 10 ~ 18 parts of Radix Cyathulae, 12 ~ 16 parts of Myrrha, 8 ~ 14 parts of Rhizoma Acori Calami.
A kind of crude drug pharmacology of Chinese medicine formula that can treat gastric ulcer of the present invention：
Fructus Aurantii：It is warm in nature, bitter in the mouth, pungent, acid.Returns spleen Jing, stomach.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Category QI regulating medicine.
Lignum Santali Albi：It is warm in nature, acrid in the mouth.Return lung Jing, stomach, spleen channel, heart channel.Circulation of qi promoting warming middle-JIAO, appetizing pain relieving.Category QI regulating medicine.
The Rhizoma Atractylodis Macrocephalae：It is warm in nature, sweet in the mouth, hardship.Returns spleen Jing, stomach.It is spleen invigorating, QI invigorating, eliminate dampness and have diuretic effect, hidroschesis, antiabortive.Under category qi-restoratives medicine
The Qi-tonifying drug of category classification.
Radix Asparagi：It is cold in nature, sweet in the mouth, hardship.Return lung Jing, kidney channel.Nourishing YIN to relieve dryness, the lung moistening and production of body fluid promoting.The benefit of category qi-restoratives medicine subordinate's classification
Cloudy medicine.
The Rhizoma Pinelliae：Warm in nature, acrid in the mouth is poisonous.Returns spleen Jing, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Category is clear
The heat clearing and dampness removing medicine of medicine of a warm nature subordinate classification.
Herba Melicae Scabrosae：It is cool in nature, sweet in the mouth.Return through without.Heat clearing away, expelling summer-heat, diuresis.The inducing diuresis to remove edema of category damp-clearing drug subordinate's classification
Medicine.
The Radix Aucklandiae：It is warm in nature, acrid in the mouth, hardship.Returns spleen Jing, stomach, large intestine channel, tri-jiao channel, gallbladder meridian.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Category
QI regulating medicine.
Flos Caryophylli：Acrid in the mouth, it is warm in nature.Return stomach, spleen channel, kidney channel.Warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.Category drugs for dispelling internal cold.
Rhizoma Dioscoreae：It is mild-natured, sweet in the mouth.Returns spleen Jing, lung meridian, kidney channel.Spleen reinforcing nourishing the stomach, engender liquid and benefic lung, the kidney invigorating arresting seminal emission.Under category qi-restoratives medicine
The Qi-tonifying drug of category classification.
Radix Cyathulae：It is mild-natured, sweet in the mouth, slight bitter.Return liver warp, kidney channel.Eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.Category promoting blood circulationization
The blood-activating and menstruation-regulating medicinal of stasis of blood medicine subordinate classification.
Myrrha：It is mild-natured, acrid in the mouth, hardship.Thoughts of returning home warp, Liver Channel, spleen channel.Scattered stasis pain, detumescence and promoting granulation.Lower point of drug for invigorating blood circulation and eliminating stasis of category
The blood-activating analgesic of class.
Rhizoma Acori Calami：It is warm in nature, it is bitter in the mouth, pungent.Thoughts of returning home warp, Liver Channel, stomach.Stomach warming, anti-inflammatory analgetic.Category digestantss.
Including 12 parts of Fructus Aurantii by weight, 20 parts of Lignum Santali Albi, 15 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Asparagi, 15 parts of the Rhizoma Pinelliae, Herba Melicae Scabrosae 10
Part, 6 parts of the Radix Aucklandiae, 6 parts of Flos Caryophylli, 16 parts of Rhizoma Dioscoreae, 18 parts of Radix Cyathulae, 12 parts of Myrrha, 14 parts of Rhizoma Acori Calami.
Including 16 parts of Fructus Aurantii by weight, 20 parts of Lignum Santali Albi, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Asparagi, 13 parts of the Rhizoma Pinelliae, Herba Melicae Scabrosae 14
Part, 10 parts of the Radix Aucklandiae, 9 parts of Flos Caryophylli, 16 parts of Rhizoma Dioscoreae, 15 parts of Radix Cyathulae, 16 parts of Myrrha, 10 parts of Rhizoma Acori Calami.
Including 13 parts of Fructus Aurantii by weight, 16 parts of Lignum Santali Albi, 17 parts of the Rhizoma Atractylodis Macrocephalae, 11 parts of Radix Asparagi, 14 parts of the Rhizoma Pinelliae, Herba Melicae Scabrosae 12
Part, 11 parts of the Radix Aucklandiae, 8 parts of Flos Caryophylli, 13 parts of Rhizoma Dioscoreae, 14 parts of Radix Cyathulae, 13 parts of Myrrha, 11 parts of Rhizoma Acori Calami.
Described Fructus Aurantii, Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae, Radix Asparagi, the Rhizoma Pinelliae, Herba Melicae Scabrosae, the Radix Aucklandiae, Flos Caryophylli, Rhizoma Dioscoreae, Radix Cyathulae, Myrrha, Tibetan Chang
Pu decocts and takes.
The present invention compared with prior art, with advantages below and beneficial effect：
The present invention is to be based on understanding and the Therapeutic Principle to gastric ulcer symptom mechanism, the directly oral method of employing, reinforcement and elimination in combination,
With strong taste, blood circulation promoting and blood stasis dispelling, QI invigorating nourishing the stomach effect, evident in efficacy, quality is easily controlled, good stability, substantially invariably
Good reaction.
Specific embodiment
The present invention is described in further detail with reference to embodiment, but embodiments of the present invention not limited to this.
Embodiment 1：
A kind of Chinese medicine formula that can treat gastric ulcer, including 12 ~ 16 parts of Fructus Aurantii by weight, 12 ~ 20 parts of Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae 15
~ 19 parts, 10 ~ 12 parts of Radix Asparagi, 10 ~ 15 parts of the Rhizoma Pinelliae, 10 ~ 16 parts of Herba Melicae Scabrosae, 6 ~ 12 parts of the Radix Aucklandiae, 6 ~ 10 parts of Flos Caryophylli, Rhizoma Dioscoreae 12 ~ 16
Part, 10 ~ 18 parts of Radix Cyathulae, 12 ~ 16 parts of Myrrha, 8 ~ 14 parts of Rhizoma Acori Calami.
The method of the present embodiment medicine preparation, including following step：
Step S1：In parts by weight, weigh 12 ~ 16 parts of Fructus Aurantii, 12 ~ 20 parts of Lignum Santali Albi, 15 ~ 19 parts of the Rhizoma Atractylodis Macrocephalae, 10 ~ 12 parts of Radix Asparagi, half
10 ~ 15 parts of summer, 10 ~ 16 parts of Herba Melicae Scabrosae, 6 ~ 12 parts of the Radix Aucklandiae, 6 ~ 10 parts of Flos Caryophylli, 12 ~ 16 parts of Rhizoma Dioscoreae, 10 ~ 18 parts of Radix Cyathulae, Myrrha
12 ~ 16 parts, 8 ~ 14 parts of Rhizoma Acori Calami, 10 ~ 16 parts of Lignum Santali Albi；
Step S2：By above-mentioned whole raw material of Chinese medicine medicines, to be soaked 30 minutes with clear water or pure water in advance, water consumption for immersion is 0.9 ~
1.1L；
Step S3：The liquid medicine of the raw material of Chinese medicine medicine after immersion and its immersion is added in decocting container, is added a cover and is decocted jointly
Two hours, dosing included following step：
Step S301：First Fructus Aurantii, Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae, Radix Asparagi are added in decocting container and are decocted 10 minutes with small fire；
Step S302：The Rhizoma Pinelliae, Herba Melicae Scabrosae, the Radix Aucklandiae, Flos Caryophylli are added in decocting container are again decocted 10 minutes with small fire；
Step S303：Rhizoma Dioscoreae, Radix Cyathulae, Myrrha, Rhizoma Acori Calami are added in decocting container again；
Step S4：First make decocting container herb liquid seethe with excitement with high heat, reuse slow fire and boil 15 ~ 20 minutes, 2 need to be stirred when boiling medicine
~ 3 times；
Step S5：After the completion of decoction, medicinal liquid is leached, obtain medicinal liquid and be endo-medicine；
Step S6：Second decoction is carried out one hour using 0.7 ~ 0.8L clear water or pure water repeat step S3 ~ S5；
Third time is carried out using 0.5 ~ 0.6L clear water or pure water repeat step S3 ~ S5 to decoct one hour.
Embodiment 2：
Including 12 parts of Fructus Aurantii by weight, 20 parts of Lignum Santali Albi, 15 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Asparagi, 15 parts of the Rhizoma Pinelliae, 10 parts of Herba Melicae Scabrosae, wood
Fragrant 6 parts, 6 parts of Flos Caryophylli, 16 parts of Rhizoma Dioscoreae, 18 parts of Radix Cyathulae, 12 parts of Myrrha, 14 parts of Rhizoma Acori Calami.
Embodiment 3：
Including 16 parts of Fructus Aurantii by weight, 20 parts of Lignum Santali Albi, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Asparagi, 13 parts of the Rhizoma Pinelliae, 14 parts of Herba Melicae Scabrosae, wood
Fragrant 10 parts, 9 parts of Flos Caryophylli, 16 parts of Rhizoma Dioscoreae, 15 parts of Radix Cyathulae, 16 parts of Myrrha, 10 parts of Rhizoma Acori Calami.
Embodiment 4：
Including 13 parts of Fructus Aurantii by weight, 16 parts of Lignum Santali Albi, 17 parts of the Rhizoma Atractylodis Macrocephalae, 11 parts of Radix Asparagi, 14 parts of the Rhizoma Pinelliae, 12 parts of Herba Melicae Scabrosae, wood
Fragrant 11 parts, 8 parts of Flos Caryophylli, 13 parts of Rhizoma Dioscoreae, 14 parts of Radix Cyathulae, 13 parts of Myrrha, 11 parts of Rhizoma Acori Calami.
Toxicology test：
Acute toxicity test：
Experimental observation, because measuring LD50, therefore has carried out the measure of maximum dosage-feeding.Chinese medicine compound prepared by embodiment 1
Mixture is dissolved in sterile saline, is configured to solution gavage mice, is as a result shown, is given birth to medicine maximum administration concentration 9.65
Medicine/ml, maximum administered volume 50ml/kg was administered twice in 24 hours to mouse stomach, and mice maximum dosage-feeding is 763.25g
There is not untoward reaction and death, each internal organs no abnormality seen of anatomic observation in crude drug/kg, animal.
Long term toxicity test：
This test applies SD rats 80, Chinese medicine compound mixture prepared by embodiment 1 to be dissolved in sterile saline, configures
Into solution gavage, if matched group and 24g, 35g, 49g crude drug/kg dosage groups, continuous gavage is administered 12 weeks, in the observation present invention
Impact of the drug composition to animal indices.Result of the test shows, successive administration 12 weeks, and the Chinese medicine composition of the present invention is to big
Body weight, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index of Mus etc. have no significant effect；Blood biochemical 12
Item index determining result, 12 weeks low dose group BiLi values of administration are higher than matched group（P<0.05)；Low dose group, middle dose group TP value
Higher than matched group（P<0.05), but within normal physiologic range, other indexs compare no significant difference with matched group.Recover
Phase, each administration group indices measured value compared equal no significant difference with matched group.The each internal organs gross examination of skeletal muscle no abnormality seen of each group.
The clinical statisticses data of various patients w ith peptic ulcer diseases is directed to using medicine of the present invention：
Through the Clinical practice of 50 patients, wherein male patient 27, female patient 23, medication age object 20 ~ 50 years old.Wherein most
It is little 21 years old, maximum 49 years old, 28 years old mean age.
Zhang, man, people from Jiangsu, 48 years old, gastroscopy the year before be multiple gastric ulcer, clinical symptoms based on having a stomach-ache,
Recently the pain increased, and emits to back, both sides of the chest and chest, and taking the medicines such as ranitidine, Losec can make remission, but be discontinued
Recur immediately afterwards, patient takes the present invention and has a stomach-ache alleviations after ten days, stool is normal, is emotionally stable, spirit is preferable.Continuous medication three
Recheck after the individual course for the treatment of, ulcer healing, it is certainly modern good to continue medication after treatment one month.
The above, is only presently preferred embodiments of the present invention, not does any pro forma restriction to the present invention, it is every according to
According to any simple modification, equivalent variations that the technical spirit of the present invention is made to above example, the protection of the present invention is each fallen within
Within the scope of.
Claims (5)
1. a kind of Chinese medicine formula that can treat gastric ulcer, it is characterised in that：Including 12 ~ 16 parts of Fructus Aurantii, Lignum Santali Albi by weight
12 ~ 20 parts, 15 ~ 19 parts of the Rhizoma Atractylodis Macrocephalae, 10 ~ 12 parts of Radix Asparagi, 10 ~ 15 parts of the Rhizoma Pinelliae, 10 ~ 16 parts of Herba Melicae Scabrosae, 6 ~ 12 parts of the Radix Aucklandiae, Flos Caryophylli 6 ~ 10
Part, 12 ~ 16 parts of Rhizoma Dioscoreae, 10 ~ 18 parts of Radix Cyathulae, 12 ~ 16 parts of Myrrha, 8 ~ 14 parts of Rhizoma Acori Calami.
2. a kind of Chinese medicine formula that can treat gastric ulcer according to claim 1, it is characterised in that：Including by weight
12 parts of Fructus Aurantii, 20 parts of Lignum Santali Albi, 15 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Asparagi, 15 parts of the Rhizoma Pinelliae, 10 parts of Herba Melicae Scabrosae, 6 parts of the Radix Aucklandiae, 6 parts of Flos Caryophylli, mountain
16 parts of medicine, 18 parts of Radix Cyathulae, 12 parts of Myrrha, 14 parts of Rhizoma Acori Calami.
3. a kind of Chinese medicine formula that can treat gastric ulcer according to claim 1, it is characterised in that：Including by weight
16 parts of Fructus Aurantii, 20 parts of Lignum Santali Albi, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Asparagi, 13 parts of the Rhizoma Pinelliae, 14 parts of Herba Melicae Scabrosae, 10 parts of the Radix Aucklandiae, 9 parts of Flos Caryophylli, mountain
16 parts of medicine, 15 parts of Radix Cyathulae, 16 parts of Myrrha, 10 parts of Rhizoma Acori Calami.
4. a kind of Chinese medicine formula that can treat gastric ulcer according to claim 1, it is characterised in that：Including by weight
13 parts of Fructus Aurantii, 16 parts of Lignum Santali Albi, 17 parts of the Rhizoma Atractylodis Macrocephalae, 11 parts of Radix Asparagi, 14 parts of the Rhizoma Pinelliae, 12 parts of Herba Melicae Scabrosae, 11 parts of the Radix Aucklandiae, 8 parts of Flos Caryophylli, mountain
13 parts of medicine, 14 parts of Radix Cyathulae, 13 parts of Myrrha, 11 parts of Rhizoma Acori Calami.
5. a kind of Chinese medicine formula that can treat gastric ulcer according to claim 1, it is characterised in that：Described Fructus Aurantii,
Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae, Radix Asparagi, the Rhizoma Pinelliae, Herba Melicae Scabrosae, the Radix Aucklandiae, Flos Caryophylli, Rhizoma Dioscoreae, Radix Cyathulae, Myrrha, Rhizoma Acori Calami are decocted and taken.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610975013.XA CN106581469A (en) | 2016-11-07 | 2016-11-07 | Traditional Chinese medicine prescription for treating gastric ulcer |
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| CN201610975013.XA CN106581469A (en) | 2016-11-07 | 2016-11-07 | Traditional Chinese medicine prescription for treating gastric ulcer |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199809A (en) * | 2007-12-19 | 2008-06-18 | 牟秉芳 | Chinese medicine prescription oral administration for treating gastric ulcer |
| CN102078414A (en) * | 2009-12-01 | 2011-06-01 | 赵莉 | Chinese patent medicine for treating gastric ulcer |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199809A (en) * | 2007-12-19 | 2008-06-18 | 牟秉芳 | Chinese medicine prescription oral administration for treating gastric ulcer |
| CN102078414A (en) * | 2009-12-01 | 2011-06-01 | 赵莉 | Chinese patent medicine for treating gastric ulcer |
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Application publication date: 20170426 |