CN106581262A - 一种含egcg的鼻炎口服液及其制作方法 - Google Patents
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Abstract
一种含EGCG的鼻炎口服液及其制作方法，其中的口服液由以下重量份的组分制成：炒苍耳子5‑10、辛夷花15‑20、白芷10‑15、炒白术10‑15、西洋参5‑10、橘红10‑15、甘草5‑10、五味子5‑10、EGCG 单体2‑5、黄芪15‑20、蜂蜜5‑10；其中的制作方法有低温超声提取、膜微滤和高温瞬时灭菌等步骤。通窍消炎，缓解因鼻炎引起的喉部不适，并能增强机体自身抵抗力，标本兼治。
Description
技术领域
本发明涉及一种口服液，更具体地说涉及一种含EGCG的鼻炎口服液及其制作方法。
背景技术
EGCG（表没食子儿茶素没食子酸酯）是从茶叶中分离得到的儿茶素类单体，是茶多酚生物活性的主要成分，其具有抗肿瘤、清除自由基、对肾脏和肝脏进行保护、抗病毒、降压、降脂、降血糖、抗突变、抑制黑色素合成、抗白血病等功效。但EGCG不能人工合成，茶叶是目前获得的唯一途径。
鼻炎指的是鼻腔粘膜和粘膜下组织的炎症，表现为充血或者水肿，患者经常会出现鼻塞，流清水涕，鼻痒，喉部不适，咳嗽等症状。目前，市面上用于治疗鼻炎的药物层出不穷，但仅专注于通窍，治标不治本，易使鼻炎反复发作，不能满足需求。
发明内容
本发明针对现有的鼻炎药物治标不治本、易使鼻炎反复发作等问题，提供一种含EGCG的鼻炎口服液及其制作方法。
为实现上述目的，本发明的技术解决方案是：.一种含EGCG的鼻炎口服液，其由以下重量份的组分制成：炒苍耳子5-10、辛夷花15-20、白芷10-15、炒白术10-15、西洋参5-10、橘红10-15、甘草5-10、五味子5-10、EGCG单体2-5、黄芪15-20、蜂蜜5-10。
一种含EGCG的鼻炎口服液的制作方法，包括以下步骤：
步骤一、取炒苍耳子、辛夷花、白芷、炒白术、西洋参、橘红、甘草、五味子、黄芪置于瓷器皿中，加入前面9种组分重量之和20倍体积的纯水，重量单位以g计，体积单位以mL计，浸泡30min，然后在40℃下超声浸提30min，离心过滤得上清液；
步骤二、将步骤一所得的上清液，经膜微滤，再经纯水稀释15-20倍，得到澄清液；
步骤三、在步骤二所得的澄清液中加入EGCG单体粉末和蜂蜜，然后搅拌调匀，得到了鼻炎口服液，从而完成了鼻炎口服液的制作。
所述的步骤三后面还包括下面的步骤：将鼻炎口服液经高温瞬时灭菌机灭菌，然后用全自动口服液灌装机灌装。
所述的高温瞬时灭菌机设置灭菌温度为135℃，灭菌时间为5-10s，物料出口温度为45℃。
所述步骤二中膜微滤所使用的膜孔径为0.05μm，操作压力为0.1-0.2MPa。
所述步骤三中得到的鼻炎口服液用波美比重计测得其波美度为0.3%-0.5%。
与现有技术相比较，本发明的有益效果是：
本发明以炒苍耳、辛夷花、白芷、炒白术、西洋参、橘红、甘草、五味子、EGCG、黄芪、蜂蜜为组成制备出一种鼻炎口服液；该配方在通窍基础上调和机体寒热，缓解因鼻炎引起的喉部不适，并能增强机体自身抵抗力，标本兼治。同时，本制作方法在工艺上采用了低温超声提取、膜微滤和高温瞬时灭菌，有效成分保留充分，安全卫生。
具体实施方式
以下结合具体实施方式对本发明作进一步的详细描述。
一种含EGCG的鼻炎口服液，其由以下重量份的组分制成：炒苍耳子5-10、辛夷花15-20、白芷10-15、炒白术10-15、西洋参5-10、橘红10-15、甘草5-10、五味子5-10、EGCG 单体2-5、黄芪15-20、蜂蜜5-10。苍耳子可发散风寒，通鼻窍；辛夷花辛散温通， 外能祛除风寒邪气，内能升达肺胃清气，通鼻窍；白芷发散风寒，且有止痛、通鼻窍等作用，还有很好的抗菌功效；炒白术能缓和燥性，健脾益气，燥湿利水；西洋参性凉，缓和燥性，补气滋阴，清肺止咳，并能增强人体免疫力；橘红性温，宽中下气，消痰；甘草补脾益气，祛痰止咳，调和诸药；五味子含有丰富的有机酸、维生素、类黄酮、植物固醇及木酚素，是少数兼具精、气、神三大补益的药材之一，可增强身体对非特异性刺激的防御能力，增加细胞免疫功能；EGCG对人体呼吸***合孢体病毒（RSV）有抑制作用，并可抗过敏、消炎；黄芪可提高肺与呼吸***免疫能力，并可用于因免疫力低下导致的虚汗病症；蜂蜜可调理脾胃，提高免疫力；因此本口服液消能够炎通窍、止咳化痰，并提高机体免疫力。
一种含EGCG的鼻炎口服液的制作方法，包括以下步骤：
步骤一、取炒苍耳子、辛夷花、白芷、炒白术、西洋参、橘红、甘草、五味子、黄芪置于瓷器皿中，加入前面9种组分重量之和20倍体积的纯水，重量单位以g计，体积单位以mL计，浸泡30min，然后在40℃下超声浸提30min，离心过滤得上清液。此处的纯水指的是可溶于水的强电解质降低到一定程度的水，在25℃温度下检测其电导率≤5.1μs/cm。
步骤二、将步骤一所得的上清液，经膜微滤，再经纯水稀释15-20倍，得到澄清液。此处的膜微滤指的是一种以静压差作为推动力、利用膜的筛分作用进行过滤分离的膜技术之一，其能够除去大分子固形悬浮物。
步骤三、在步骤二所得的澄清液中加入EGCG粉和蜂蜜，然后搅拌调匀，得到了鼻炎口服液，从而完成了鼻炎口服液的制作。
进一步的，所述的步骤三后面还包括下面的步骤：将鼻炎口服液经高温瞬时灭菌机灭菌，然后用全自动口服液灌装机灌装。并将高温瞬时灭菌机设置灭菌温度为135℃，灭菌时间为5-10s，物料出口温度为45℃。同时可以选择全自动口服液灌装机每瓶灌装量为8ml。
具体的，所述步骤二中膜微滤所使用的膜孔径为0.05μm，操作压力为0.1-0.2MPa。
具体的，所述步骤三中得到的鼻炎口服液用波美比重计测得其波美度为0.3%-0.5%。此处的波美度是表示溶液浓度的一种方法，其单位为°Bé。
以上内容是结合具体的优选实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干简单推演或替换，上述结构都应当视为属于本发明的保护范围。
Claims (6)
1.一种含EGCG的鼻炎口服液，其特征在于，其由以下重量份的组分制成：炒苍耳子5-10、辛夷花15-20、白芷10-15、炒白术10-15、西洋参5-10、橘红10-15、甘草5-10、五味子5-10、EGCG单体2-5、黄芪15-20、蜂蜜5-10。
2.根据权利要求1所述的一种含EGCG的鼻炎口服液的制作方法，其特征在于，包括以下步骤：
步骤一、取炒苍耳子、辛夷花、白芷、炒白术、西洋参、橘红、甘草、五味子、黄芪置于瓷器皿中，加入前面9种组分重量之和20倍体积的纯水，重量单位以g计，体积单位以mL计，浸泡30min，然后在40℃下超声浸提30min，离心过滤得上清液；
步骤二、将步骤一所得的上清液，经膜微滤，再经纯水稀释15-20倍，得到澄清液；
步骤三、在步骤二所得的澄清液中加入EGCG单体粉末和蜂蜜，然后搅拌调匀，得到了鼻炎口服液，从而完成了鼻炎口服液的制作。
3.根据权利要求2所述的一种含EGCG鼻炎口服液的制作方法， 其特征在于，所述的步骤三后面还包括下面的步骤：
将鼻炎口服液经高温瞬时灭菌机灭菌，然后用全自动口服液灌装机灌装。
4.根据权利要求3所述的一种含EGCG鼻炎口服液的制作方法， 其特征在于：所述的高温瞬时灭菌机设置灭菌温度为135℃，灭菌时间为5-10s，物料出口温度为45℃。
5.根据权利要求2所述的一种含EGCG鼻炎口服液的制作方法，其特征在于：所述步骤二中膜微滤所使用的膜孔径为0.05μm，操作压力为0.1-0.2MPa。
6.根据权利要求2所述的一种含EGCG鼻炎口服液的制作方法，其特征在于：所述步骤三中得到的鼻炎口服液用波美比重计测得其波美度为0.3%-0.5%。
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