CN106580516A - Degradable biliary duct drug-eluting stent - Google Patents
Degradable biliary duct drug-eluting stent Download PDFInfo
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- CN106580516A CN106580516A CN201611061686.0A CN201611061686A CN106580516A CN 106580516 A CN106580516 A CN 106580516A CN 201611061686 A CN201611061686 A CN 201611061686A CN 106580516 A CN106580516 A CN 106580516A
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- Prior art keywords
- degradable
- bile duct
- prosthesises
- biliary tract
- overlay film
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2002/041—Bile ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a degradable biliary duct drug-eluting stent, which consists of a biliary duct stent body and a biodegradable high-molecular polymer coating arranged on the surface of the biliary duct stent body. The biliary duct stent body is formed by mixed braiding of biodegradable metal wires and biodegradable high-molecular material silk threads. The biliary duct stent body is of a tubular structure. The two ends of the biliary duct stent body are shaped like trumpets that are open outwardly. The surface of the biliary duct stent body is a netted surface. The biodegradable high-molecular polymer coating carries drugs. The degradable biliary duct drug-eluting stent plays a mechanical supporting effect in a short period, is completely degraded after a treatment effect disappears, prevents tube wall tissues from being stimulated for a long period of time, effectively prevents the wall tissues from narrowing again after an operation, enables drug loaded fiber films to evenly wrap the surface of the stent body, and makes the drugs release slowly.
Description
Technical field
The present invention relates to a kind of biliary tract prosthesises, more particularly to a kind of degradable bile duct support of overlay film administration.
Background technology
It is a kind of common benign biliary tract disease of clinic that benign ductal is narrow, it is main concurrent in postcholecystectomy,
After liver transplantation, chronic pancreatitiss, Pancreatic Psoudocyst, choledocholithiasis, sclerosing cholangitiss and other related biliary tracts
Disease.After bile duct injury, cicatrization is most basic pathological change, and the narrow complication of benign ductal mainly has liver function zymetology
Change, obstructive jaundice, the cholangitis of recurrent exerbation, secondary biliary cirrhosis etc., in order to prevent the generation of complication, need
Carry out that early stage is appropriate and effectively treatment.Biliary tract prosthesises implantation can be released because the esophaguses caused by bile duct Malignant and benign lesions are narrow
The problems such as narrow, obstruction, effectively reduction of patient clinical symptoms, in wide clinical application.Clinical research confirmation, biliary tract prosthesises are put
Entering art treatment benign biliary stricture can obtain satisfied effect.
The T-shaped pipe of surgical operation and U-tube can often oppress bile duct and cause epithelial proliferation and fibrosiss, and patient needs length
Phase band governance is treated, and is made troubles to life.Balloon dilatation is also the indispensable treatment commonly used in benign ductal narrow treatment
Method, especially for the narrow of postoperative anastomotic stoma, bile duct caliber is adjusted by sacculus so as to can at short notice reach ideal
Caliber, shortens the wait cholangiectasiss time.But or Cholangio- jejunostomy narrow for common hepatic duct joint portion is narrow to be difficult with outside
Section performs the operation and therapeutic endoscopy, and the mode for being used alone balloon expandable occurs many complication.
With the development of material technology, be applied to now benign biliary stricture biliary tract prosthesises be mainly plastics endoprosthesises and
Metal rack.
Plastics endoprosthesises are easily placed and take out, short run effect significantly and low price, but due to poor biocompatibility, easily
Displacement and blocking, need repeatedly row ERCP to change support, and treatment cycle extends, while also increasing pyogenic cholangitis, bile duct
The incidence rate of the complication such as calculus, should not place for a long time.
The caliber of metal rack is larger, has the incidence rate of fine mechanics spreading performance, persistent, displacement and obstruction low.
But because the high intensity of metal rigidly causes support to be not easily taken out, pain, perforation, bleeding and strong are caused after taking out by force
The complication such as foreign body reaction.Tinsel is often imbedded within bile duct wall internal stimuluss epithelial hyperplasia, and tumor tissues also easily pass through net
Hole is grown in support.
Can not be degradable when plastics endoprosthesises and metal rack are used as biliary tract prosthesises, all need after treatment is finished
Take out, it is easy to cause biliary duct injury, induce bleeding.
In view of above-mentioned defect, the design people, positive in addition research and innovation, to founding a kind of dropping for overlay film administration
Solution biliary tract prosthesises so as to more value clinically.
The content of the invention
To solve above-mentioned technical problem, it is an object of the invention to provide a kind of degradable bile duct support of overlay film administration, energy
Enough to play mechanical support effect in a short time, after the completion of effect to be treated, support is degradable, it is to avoid to the long-term of tube wall tissue
Foreign body stimulates, and effectively prevents postoperative restenosis.
A kind of degradable bile duct support of overlay film administration proposed by the present invention, can by biodegradable metals silk thread and biology
The biliary tract prosthesises body of degraded macromolecular material silk thread mixed weaving gathers with the Biodegradable high-molecular for overlaying on its surface
Compound coating is constituted；In tubular construction, the two ends of the biliary tract prosthesises body are in outwardly loudspeaker for the biliary tract prosthesises body
Shape, the surface of the biliary tract prosthesises body is in latticed；The Biodegradable high-molecular polymer coating is loaded with medicine.
Further, described biodegradable metals are magnesium alloy.
Further, described Biodegradable polymer material is polydioxanone.
Further, described Biodegradable high-molecular polymer coating is biodegradable elastomeric polymer Nanowire
Dimension film.
Further, described Biodegradable high-molecular polymer selected from polylactic acid, polycaprolactone, polyglycolic acid,
Polycaprolactone, polyhydroxybutyrate valerate, Polyethylene Glycol, PTMC this it is several in one kind.
Further, the Biodegradable high-molecular polymer is polycaprolactone or PTMC.
Further, the medicine that the Biodegradable high-molecular polymer coating is loaded with is paclitaxel.
Further, the medicine that the Biodegradable high-molecular polymer coating is loaded with is sirolimuss
Further, described Biodegradable high-molecular polymer is coated uniformly on bile duct by electrostatic spinning technique
On the surface of frame body.
Further, the thickness of the biliary tract prosthesises body is the Biodegradable high-molecular polymer coating thickness
5-10 times.
By such scheme, the present invention at least has advantages below：
1. by biodegradable metals silk thread and the bile duct of Biodegradable polymer material silk thread mixed weaving
Rack body not only possesses its preferable mechanical strength and rebound performance, while can be degradable in vivo；
2. biodegradable polymer coating is covered in biliary tract prosthesises body surface, can temporarily avoid biliary tract prosthesises sheet
Body causes its fast erosion because of contact corrosion environment, and the polymer coating also has degradability such that it is able to build
Biliary tract prosthesises that can be degradable, can in a short time play mechanical support effect after implantation human body, after the completion of effect to be treated,
Support is degradable, it is to avoid the long-term foreign body of tube wall tissue is stimulated, postoperative restenosis are effectively prevented；
3. medicine is loaded with biodegradable polymer coating, can be uniform as biodegradable drug-loading fibre film
It is coated on biliary tract prosthesises body, so that medicine can be uniformly distributed on biliary tract prosthesises.
4. there is the characteristic of slow Slow release, energy using the Biodegradable fibers film covered on biliary tract prosthesises body
The slow release of medicine is enough realized, so as to preferably be made therapeutic effect.
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be practiced according to the content of description, below with presently preferred embodiments of the present invention and coordinate accompanying drawing describe in detail as after.
Description of the drawings
Fig. 1 is the structural representation of biliary tract prosthesises body of the present invention；
Fig. 2 is the schematic diagram that biliary tract prosthesises body surface of the present invention covers Biodegradable high-molecular polymer coating；
Fig. 3 is the electron microscope of the polycaprolactone nano fibrous membrane that medicine is not carried in the present invention；
Fig. 4 is the electron microscope of the polycaprolactone nano fibrous membrane that paclitaxel is carried in the present invention；
Fig. 5 is the mechanics compression curve figure of biliary tract prosthesises body of the present invention；
Fig. 6 is the mechanics rebound curve figure of biliary tract prosthesises body of the present invention；
Fig. 7 is that the mechanics compression of the biliary tract prosthesises body that surface is covered with polycaprolactone fibrous membrane in the embodiment of the present invention one is bent
Line chart；
Fig. 8 is that the mechanics resilience of the biliary tract prosthesises body that surface is covered with polycaprolactone fibrous membrane in the embodiment of the present invention one is bent
Line chart；
Fig. 9 is the polycaprolactone fibrous membrane of paclitaxel loaded medicine of the invention in phosphate buffered solution and bile solutions
Drug release patterns；
Figure 10 is that the smooth muscle of biliary tract prosthesises body of the present invention and the biliary tract prosthesises body for being covered with paclitaxel loaded medicine is thin
Born of the same parents' compatibility schematic diagram.
Specific embodiment
With reference to the accompanying drawings and examples, the specific embodiment of the present invention is described in further detail.Hereinafter implement
Example is not limited to the scope of the present invention for illustrating the present invention.
Embodiment one：A kind of degradable bile duct support of overlay film administration, with magnesium alloy silk thread and polydioxanone (PDO) silk
Line mixed weaving, further in biliary tract prosthesises body surface electrostatic spinning technique, is covered with poly- into degradable bile duct support body
The nano fibrous membrane of caprolactone-taxol drug, the film has slow release medicinal property, and the original power for not affecting support
The characteristics such as performance are learned, additionally, the film is also degradable macromolecule carrier, therefore the gallbladder of the overlay film administration of a degradable is constructed
Pipe holder.In tubular construction, the two ends of the biliary tract prosthesises body are in outwardly horn-like, the gallbladder to the biliary tract prosthesises body
The surface of pipe holder body is in latticed.
Embodiment two：A kind of degradable bile duct support of overlay film administration, with magnesium alloy silk thread and polydioxanone (PDO) silk
Line mixed weaving, further in biliary tract prosthesises body surface electrostatic spinning technique, is covered with poly- into degradable bile duct support body
The nano fibrous membrane of trimethylene carbonate-taxol drug, the film has slow release medicinal property, and does not affect support
The characteristic such as original mechanical property, additionally, the film is also degradable macromolecule carrier, therefore construct the overlay film of a degradable
The biliary tract prosthesises of administration.In tubular construction, the two ends of the biliary tract prosthesises body are in outwardly loudspeaker for the biliary tract prosthesises body
Shape, the surface of the biliary tract prosthesises body is in latticed.
Embodiment three：A kind of degradable bile duct support of overlay film administration, with magnesium alloy silk thread and polydioxanone (PDO) silk
Line mixed weaving, further in biliary tract prosthesises body surface electrostatic spinning technique, is covered with poly- into degradable bile duct support body
The nano fibrous membrane of caprolactone-sirolimus drug, the film has slow release medicinal property, and does not affect the original of support
The characteristics such as mechanical property, additionally, the film is also degradable macromolecule carrier, therefore construct the overlay film administration of a degradable
Biliary tract prosthesises.The biliary tract prosthesises body in tubular construction, in outwardly horn-like be somebody's turn to do by the two ends of the biliary tract prosthesises body
The surface of biliary tract prosthesises body is in latticed.
Example IV：A kind of degradable bile duct support of overlay film administration, with magnesium alloy silk thread and polydioxanone (PDO) silk
Line mixed weaving, further in biliary tract prosthesises body surface electrostatic spinning technique, is covered with poly- into degradable bile duct support body
The nano fibrous membrane of trimethylene carbonate-sirolimus drug, the film has slow release medicinal property, and does not affect to prop up
The characteristics such as original mechanical property of frame, additionally, the film is also degradable macromolecule carrier, therefore construct covering for degradable
The biliary tract prosthesises of film administration.In tubular construction, the two ends of the biliary tract prosthesises body are in outwardly for the biliary tract prosthesises body
Horn-like, the surface of the biliary tract prosthesises body is in latticed.
Embodiment five：A kind of degradable bile duct support of overlay film administration, with magnesium alloy silk thread and polydioxanone (PDO) silk
Line mixed weaving, further in biliary tract prosthesises surface electrostatic spinning technique, is covered with poly- caproic acid into degradable bile duct support body
The fibrous membrane of propyl ester-taxol drug, the film has slow release medicinal property, and the original mechanical property for not affecting support
Etc. characteristic, additionally, the film is also degradable macromolecule carrier, therefore the bile duct of the overlay film administration of a degradable is constructed
Frame.In tubular construction, the two ends of the biliary tract prosthesises body are in outwardly horn-like, bile duct for the biliary tract prosthesises body
The surface of frame body is in latticed.
Embodiment six：A kind of degradable bile duct support of overlay film administration, with magnesium alloy silk thread and polydioxanone (PDO) silk
Line mixed weaving, further in biliary tract prosthesises surface electrostatic spinning technique, is covered with poly- hydroxyl into degradable bile duct support body
The fibrous membrane of amyl butyrate-taxol drug, the film has slow release medicinal property, and the original mechanics for not affecting support
The characteristics such as performance, additionally, the film is also degradable macromolecule carrier, therefore construct the bile duct of the overlay film administration of a degradable
Support.In tubular construction, the two ends of the biliary tract prosthesises body are in outwardly horn-like, the bile duct to the biliary tract prosthesises body
The surface of rack body is in latticed.
The principle of the degradable bile duct support of overlay film administration is in above-described embodiment：By degradable metal silk thread symphysis thing
Degradable high polymer material silk thread mixed weaving into biodegradable biliary tract prosthesises body, and in biliary tract prosthesises body surface system
Standby upper biodegradable polymer coating, make biliary tract prosthesises body not only possess itself mechanical property and and rebound performance,
The surface property of biodegradable polymer is provided simultaneously with, by biliary tract prosthesises body surface coating of high molecular polymer come temporarily
Biliary tract prosthesises body is avoided to cause its fast erosion because of contact corrosion environment, and due to biliary tract prosthesises body surface degradable
Coating of high molecular polymer and biliary tract prosthesises body itself all have degradability, its advantage as non-permanent implant
Also will emerge from out, so as to, build can degradable biliary tract prosthesises, can in a short time play mechanics after implantation human body
Support is acted on, and after the completion of effect to be treated, support is degradable, it is to avoid the long-term foreign body of tube wall tissue is stimulated, art is effectively prevented
Restenosiss afterwards.The biodegradable polymer that simultaneously biliary tract prosthesises body surface covers has slow release medicinal property, by it
Uniformly it is wrapped on biliary tract prosthesises body as drug-loading fibre film, the slow release of medicine can be realized.
The above is only the preferred embodiment of the present invention, is not limited to the present invention, it is noted that for this skill
For the those of ordinary skill in art field, on the premise of without departing from the technology of the present invention principle, can also make it is some improvement and
Modification, these are improved and modification also should be regarded as protection scope of the present invention.
Claims (10)
1. the degradable bile duct support that a kind of overlay film is administered, it is characterised in that：Can be dropped by biodegradable metals silk thread and biology
The biliary tract prosthesises body of solution macromolecular material silk thread mixed weaving and the Biodegradable high-molecular polymerization for overlaying on its surface
Thing coating is constituted；The biliary tract prosthesises body in tubular construction, the two ends of the biliary tract prosthesises body in outwardly horn-like,
The surface of the biliary tract prosthesises body is in latticed；The Biodegradable high-molecular polymer coating is loaded with medicine.
2. the degradable bile duct support that a kind of overlay film according to claim 1 is administered, it is characterised in that：Described biology can
Degraded metal is magnesium alloy.
3. the degradable bile duct support that a kind of overlay film according to claim 1 is administered, it is characterised in that：Described biology can
Degraded macromolecular material is polydioxanone.
4. the degradable bile duct support that a kind of overlay film according to claim 1 is administered, it is characterised in that：Described biology can
Degraded macromolecular polymer coating is biodegradable elastomeric polymer nano fibrous membrane.
5. the degradable bile duct support that a kind of overlay film according to claim 4 is administered, it is characterised in that：Described biology can
Degraded macromolecular polymer is selected from polylactic acid, polycaprolactone, polyglycolic acid, polycaprolactone, polyhydroxybutyrate valerate, poly- second
Glycol, PTMC this it is several in one kind.
6. the degradable bile duct support that a kind of overlay film according to claim 5 is administered, it is characterised in that：The biology can drop
Solution high molecular polymer is polycaprolactone or PTMC.
7. the degradable bile duct support that a kind of overlay film according to claim 1 is administered, it is characterised in that：The biology can drop
The medicine that solution coating of high molecular polymer is loaded with is paclitaxel.
8. the degradable bile duct support that a kind of overlay film according to claim 1 is administered, it is characterised in that：The biology can drop
The medicine that solution coating of high molecular polymer is loaded with is sirolimuss.
9. the degradable bile duct support that a kind of overlay film according to claim 1 is administered, it is characterised in that：Described biology can
Degraded macromolecular polymer is coated uniformly on the surface of biliary tract prosthesises body by electrostatic spinning technique.
10. the degradable bile duct support that a kind of overlay film according to claim 1 is administered, it is characterised in that：The bile duct
The thickness of frame body is 5-10 times of the Biodegradable high-molecular polymer coating thickness.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611061686.0A CN106580516A (en) | 2016-11-28 | 2016-11-28 | Degradable biliary duct drug-eluting stent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611061686.0A CN106580516A (en) | 2016-11-28 | 2016-11-28 | Degradable biliary duct drug-eluting stent |
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| CN106580516A true CN106580516A (en) | 2017-04-26 |
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| CN201611061686.0A Pending CN106580516A (en) | 2016-11-28 | 2016-11-28 | Degradable biliary duct drug-eluting stent |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107469156A (en) * | 2017-09-30 | 2017-12-15 | 焦德超 | A kind of film covering type Y type biliary tract prosthesises for being locally covered with chemotherapeutics |
| CN108853574A (en) * | 2017-05-10 | 2018-11-23 | 上海交通大学 | Magnesium alloy and kirsite silk material shuffling composite patch and application thereof |
| CN108853587A (en) * | 2017-05-10 | 2018-11-23 | 上海交通大学 | Magnesium alloy and macromolecule silk material shuffling composite patch and application thereof |
| CN111939330A (en) * | 2020-07-22 | 2020-11-17 | 苏州晶俊新材料科技有限公司 | Zinc alloy anastomosis nail and preparation method thereof |
| CN112826988A (en) * | 2021-02-22 | 2021-05-25 | 复旦大学附属中山医院 | Directionally degradable self-shedding magnesium metal biliary stent and preparation method thereof |
| CN113509290A (en) * | 2021-07-09 | 2021-10-19 | 乐普（北京）医疗器械股份有限公司 | Biliary tract stent, sealed storage box and loader |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853574A (en) * | 2017-05-10 | 2018-11-23 | 上海交通大学 | Magnesium alloy and kirsite silk material shuffling composite patch and application thereof |
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| CN107469156A (en) * | 2017-09-30 | 2017-12-15 | 焦德超 | A kind of film covering type Y type biliary tract prosthesises for being locally covered with chemotherapeutics |
| CN107469156B (en) * | 2017-09-30 | 2020-04-14 | 郑州大学第一附属医院 | Laminated Y-shaped bile duct stent partially covered with chemotherapeutic drugs |
| CN111939330A (en) * | 2020-07-22 | 2020-11-17 | 苏州晶俊新材料科技有限公司 | Zinc alloy anastomosis nail and preparation method thereof |
| CN112826988A (en) * | 2021-02-22 | 2021-05-25 | 复旦大学附属中山医院 | Directionally degradable self-shedding magnesium metal biliary stent and preparation method thereof |
| CN112826988B (en) * | 2021-02-22 | 2023-11-24 | 复旦大学附属中山医院 | Directionally degradable self-shedding magnesium metal biliary tract stent and preparation method thereof |
| CN113509290A (en) * | 2021-07-09 | 2021-10-19 | 乐普（北京）医疗器械股份有限公司 | Biliary tract stent, sealed storage box and loader |
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