CN106562057A - Piglet intestine nutrition regulation and control feed containing cladded zinc oxide - Google Patents
Piglet intestine nutrition regulation and control feed containing cladded zinc oxide Download PDFInfo
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- CN106562057A CN106562057A CN201610966604.0A CN201610966604A CN106562057A CN 106562057 A CN106562057 A CN 106562057A CN 201610966604 A CN201610966604 A CN 201610966604A CN 106562057 A CN106562057 A CN 106562057A
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- zinc oxide
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- sodium butyrate
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Abstract
The invention discloses a piglet intestine nutrition regulation and control feed based on cladded zinc oxide. The complete feed comprises 0.06-0.2wt% of cladded zinc oxide and 0.1-0.2wt% of sodium butyrate. The cladded zinc oxide is prepared by performing cladding on ingredients such as stearic acid, long-chain rice bran oil, silicate and carboxymethyl cellulose sodium by use of an inlaid cladding technology, has the effect of effectively preventing zinc oxide from being acidified into zinc ions and consuming hydrogen ions in piglet stomaches and is capable of improving the activity of pepsin, so that the active ingredient (zinc oxide) efficiently enter into an intestinal tract so as to exert effects of resisting bacteria and protecting intestinal mucosa mucoprotein structure; sodium butyrate has an effect of rapidly supplying energy nutrients to piglet intestine mucous cells, and has a food attractant effect on piglets due to unique smell. Cladded zinc oxide and sodium butyrate can achieve a synergetic effect and exert respective effects of protecting the intestinal mucosa mucoprotein structure and promoting mucosa epithelial cell growth, and the effects of improving the feed intake of weanling piglets and obviously reducing the after-weanling diarrhoea rate. The piglet intestine nutrition regulation and control feed is capable of obviously reducing the diarrhoea rate of weanling piglets and improving the feed intake and growth property of the weanling piglets.
Description
Technical field
The present invention relates to a kind of piglet intestinal canal nutrition controlling feed based on coating zinc oxide.
Background technology
Pig Industry industry generally using early stage or ultra-early weaning, easily cause the reduction of early-weaned pigletses immunologic function with
Diarrhoea, enteron aisle 26S Proteasome Structure and Function is disorderly, and severe patient results even in death.In order to solve " weaning syndrome " of weanling pig.
Diet addition 2500-4000mg/kg zinc (zinc oxide) has significant growth promotion and anti diar rhea effect to weanling pig
Really, but high dose zinc oxide can cause certain toxic action to piglet, occur by hair slightly it is long disorderly, skin is matt and after affecting
Phase such as grows at the phenomenon.Simultaneously high dose zinc oxide major part is excreted in environment with excrement, causes environmental pollution.Therefore grind
System is a kind of efficiently, safety, novel oxidized zinc-type feed produce significant to weanling pig.
Zinc oxide is the sour power material of high system, and high dose zinc oxide reacts generation ZnCl in piglet gastric acid environment2, make reality
The efficient oxidation zinc quantity for reaching enteron aisle is substantially reduced.Experiment finds, common zinc oxide under SGF environment after 3 hours,
Its dissociation disappearance rate is in 80%-90%.By coating technique, the coating for wrapping opposing hydrochloric acid in gastric juice in zinc oxide core surfaces is realized prolonging
Slowbreak is put, and keeps active ingredient zinc oxide stablizing under gastric acid environment, is replaced using the coating zinc oxide of low dosage at present
High zinc in production, on this basis, develop it is a kind of it is new, efficient, can Long-Time Service, safety coating oxidation zinc-type piglet intestines
Road nutrition regulation feed is significant, is favorably improved the safety of livestock products and reduces pollution of a large amount of zinc to environment.
Using coating technique is inlayed, the coating for wrapping opposing hydrochloric acid in gastric juice in zinc oxide core surfaces realizes sustained release, in mould
Intend in gastric juice after 0.5h, 1h, 2h, 3h, 4h, under the conditions of pH=2, the dissociation yield of coating zinc oxide be 1.47%～2.21% it
Between, keep active ingredient zinc oxide stablizing under gastric acid environment.In simulated intestinal fluid, under the conditions of pH=5,6,7, coating oxygen
Change zinc release and be respectively 85.96%, 92.76% and 95.40%, experiment shows that coating zinc oxide can be progressively in simulated intestinal fluid
Zinc oxide is discharged, release is good；Low dosage coating zinc oxide has reached high dose zinc oxide in Animal experiment
(2250mg/kg) growth-promoting effect, and the excretion of zinc in excrement sample is greatly lowered, reduce environmental pollution.
The content of the invention
It is an object of the invention to provide a kind of piglet intestinal canal nutrition controlling feed based on coating zinc oxide.
A kind of piglet intestinal canal nutrition controlling feed based on coating zinc oxide of the present invention, coating zinc oxide in complete feed
Shared percentage by weight is 0.06～0.2%, and percentage by weight shared by sodium butyrate is 0.1～0.2%.
Coating zinc oxide described in the present invention is with materials such as stearic acid, long-chain rice bran oil, sub- silicic acid, sodium cellulose glycolates
Material, is formed using coating technique coating is inlayed, and zinc oxide content is 48-50%.Sodium butyrate is n-butyric acie sodium salt, and molecular formula is
C4H7O2Na, relative molecular mass is 110.09, it is white to off-white color can hygroscopic powder.After 21-25 age in days weaned piglets
Start to add 0.6～2 kilogram of coating zinc oxide and 1～2 kilogram of sodium butyrate in complete feed per ton.
The 1950's finds that zinc has important function in pig nutrition and human nutrition, confirms that zinc is people and animal institute
One of required trace element.Zinc is the part of various enzymes and albumen, including more than 300 kinds of enzyme and transcription factor, thin
Born of the same parents' signal transducer, maintains body normal immunological function, regulatory protein matter metabolism to maintain cell membrane integrity, participate in cell
Propagation with differentiation.Zinc can pass through the composition for participating in oxidative metabolism relevant enzymes, adjust the balance of the oxygen radical in body；It is logical
Cross the direct propagation for adjusting cell of synthesis for participating in DNA.
Danish scientist in 1989 finds that adding 2500-4000mg/kg zinc oxide in weanling pig daily ration can significantly carry
High weaned piglets, dramatically increase piglet feed intake, improve its average daily gain.Numerous studies are further proved in daily ration
Addition 2000-4000mg/kg zinc oxide can significantly reduce diarrhea of weaned piglets rate, piglet growth performance be improved, while significantly
Lactulose and the ratio of mannitol in piglet urine are reduced, intestinal permeability is reduced, promotes closely to connect in intestinal mucosa
The gene expression amount of albumen Occludin and ZO-1.Occludin and ZO-1 are to constitute close-connected cross-film between enterocyte
Albumen and cytoplasmic protein, they have important function to the permeability for controlling intestinal epithelial barrier.Add in weanling pig daily ration
2500mg/kg zinc oxide is remarkably improved the activity of protease in piglet pancreatic tissue, increases height of naps, the fine hair width of small intestine
Degree and mucous membrane thickness, while reducing its Crypt depth, improve digestion and absorption function of the weanling pig small intestine to nutriment, increase
Plus the supply of Parenteral Nutrition material.Vitro Experimental Results show that zinc oxide has the antibacterial activity of broad-spectrum, and zinc oxide can make son
Escherichia coli quantity is significantly reduced in chitterlings content.High dose zinc oxide can cause certain toxic action to piglet, go out
Now by hair, slightly long random, skin is matt and affects the phenomenons such as later period growth and development, while high dose zinc oxide major part is with excrement
In being excreted to environment, environmental pollution is caused.
Sodium butyrate (n-butyric acie sodium salt, C4H7O2Na), it is white to off-white color, like it is villous can hygroscopic powder, have
Special cheese becomes sour sample smell, soluble in water, and aqueous solution pH is in alkalescent.Research finds that butyric acid is easily inhaled in animal enteric cavity
Receive, need not move through liver and gall and absorb and the three complicated hydroxyl circulatory systems, energy can be provided for enteron aisle, be the quick of enterocyte
Energy source, is the main energy sources of intestinal epithelial cell, accounts for the 70% of SCFA oxygen consumptions institute production capacity amount.Raise in weanling pig
Adding sodium butyrate in grain can promote small intestine goblet cell to breed, and improve the morphosis of small intestinal mucosa epithelial cell, maintain small intestine
The integrality of mucosa structure and function, increases intestinal beneficial bacterium quantity, suppresses or reduce the quantity of harmful bacteria, maintains the micro- life of enteron aisle
Thing flora is stablized.
Therefore the coating zinc oxide and sodium butyrate of the present invention can play unique effect each to intestines structure function, and collaboration is produced
The effects such as raw reduction diarrhea of weaned piglets rate, raising growth performance.
The piglet intestinal canal nutrition controlling feed containing coating zinc oxide of the present invention, improves can piglet average daily gain
20%-31%, feed-weight ratio reduces 10%-12%, and diarrhea rate declines 75%-80%, and jejunum villi highly improves 60%-90%,
Crypt depth declines 20%-50%, and duodenum enterokinase activity improves 30%-35%, and the activity of jejunal mucous membrane lactase is carried
High 25%-35%, sucrase active improves 30%-60%.
Specific embodiment
The present invention is further described with reference to following instance.
Embodiment 1
25 age in days weaned piglets start, control group fed control daily ration (formula is shown in Table 1).Test group complete feed is to right
According to coating zinc oxide 0.06% or sodium butyrate 0.1% is added on the basis of group daily ration, above-mentioned feed is fed to 46 ages in days, determine piglet
Growth performance.
The test diet composition of table 1 and nutritive index
Result of the test shows, compared with control group, the average daily gain of coating zinc oxide test group piglet improves 10% (P<
0.05), feed-weight ratio reduces by 6% (P<0.05), diarrhea rate declines 45% (P<0.05), jejunum villi highly improves 20% (P<
0.05), Crypt depth declines 10% (P<0.05), duodenum enterokinase activity improves 18% (P<0.05), jejunal mucous membrane breast
The activity of carbohydrase improves 15% (P<0.05), sucrase active improves 20% (P<0.05)；Sodium butyrate test group piglet average day
Weightening raising 8%P (<0.05), feed-weight ratio reduces by 7% (P<0.05), diarrhea rate declines 25% (P<0.05), jejunum villi height
Improve 18% (P<0.05), Crypt depth declines 12% (P<0.05), duodenum enterokinase activity improves 16% (P<0.05),
The activity of jejunal mucous membrane lactase improves 13% (P<0.05), sucrase active improves 17% (P<0.05).
Embodiment 2
25 age in days weaned piglets start, control group fed control daily ration (formula is shown in Table 1).Test group complete feed is to right
According to coating zinc oxide 0.06% is added on the basis of group daily ration, sodium butyrate 0.1% feeds above-mentioned feed to 46 ages in days, determines piglet
Growth performance.
The test diet composition of table 1 and nutritive index
Result of the test shows, compared with control group, test group piglet average daily gain improves 20%P<0.05), feed-weight ratio
Reduce by 10% (P<0.05), diarrhea rate declines 75% (P<0.01), jejunum villi highly improves 60% (P<0.05), Crypt depth
Decline 20% (P<0.05), duodenum enterokinase activity improves 30% (P<0.05), the activity raising of jejunal mucous membrane lactase
25% (P<0.05), sucrase active improves 30% (P<0.05).
Embodiment 3
21 age in days weaned piglets start, control group fed control daily ration (formula is shown in Table 1).Test group complete feed is to right
According to coating zinc oxide 0.2% is added on the basis of group daily ration, sodium butyrate 0.2% feeds above-mentioned feed to 42 ages in days, determines piglet life
Long performance.
The test diet composition of table 1 and nutritive index
Result of the test shows, compared with control group, test group piglet average daily gain improves 31%P<0.01), feed-weight ratio
Reduce by 12% (P<0.05), diarrhea rate declines 80% (P<0.01), jejunum villi highly improves 90% (P<0.01), Crypt depth
Decline 50% (P<0.05), duodenum enterokinase activity improves 35% (P<0.05), the activity raising of jejunal mucous membrane lactase
35% (P<0.05), sucrase active improves 60% (P<0.01).
Claims (3)
1. a kind of piglet intestinal canal nutrition controlling feed containing coating zinc oxide, it is characterised in that coating zinc oxide in complete feed
Shared percentage by weight is 0.06～0.2%, and percentage by weight shared by sodium butyrate is 0.1～0.2%.
2. a kind of piglet intestinal canal nutrition controlling feed based on coating zinc oxide according to claim 1, it is characterised in that
The coated fertilizer of described coating zinc oxide is stearic acid, long-chain rice bran oil, sub- silicic acid or sodium cellulose glycolate, zinc oxide institute
It is 48-50% to account for percentage by weight, and described sodium butyrate is n-butyric acie sodium salt, and molecular formula is C4H7O2Na。
3. piglet intestinal canal nutrition controlling feed described in claim 1 or 2 in the growth of 21-25 ages in days weanling pigs is promoted should
With.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610966604.0A CN106562057A (en) | 2016-11-02 | 2016-11-02 | Piglet intestine nutrition regulation and control feed containing cladded zinc oxide |
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| CN201610966604.0A CN106562057A (en) | 2016-11-02 | 2016-11-02 | Piglet intestine nutrition regulation and control feed containing cladded zinc oxide |
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| CN111657395A (en) * | 2020-06-19 | 2020-09-15 | 山西农业大学 | Feed additive, preparation method thereof and dairy cow feed |
| CN114009618A (en) * | 2021-12-17 | 2022-02-08 | 沈阳农业大学 | Feed additive for preventing intestinal barrier injury of piglets and preparation method and application thereof |
| CN114586895A (en) * | 2022-01-05 | 2022-06-07 | 安池(山东)动物营养研究院有限公司 | Functional bag for relieving piglet weaning stress and preparation method thereof |
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| CN114009618A (en) * | 2021-12-17 | 2022-02-08 | 沈阳农业大学 | Feed additive for preventing intestinal barrier injury of piglets and preparation method and application thereof |
| CN114586895A (en) * | 2022-01-05 | 2022-06-07 | 安池(山东)动物营养研究院有限公司 | Functional bag for relieving piglet weaning stress and preparation method thereof |
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