CN106561652A - Isosakuranetin containing sterilizing combination - Google Patents
Isosakuranetin containing sterilizing combination Download PDFInfo
- Publication number
- CN106561652A CN106561652A CN201610906122.6A CN201610906122A CN106561652A CN 106561652 A CN106561652 A CN 106561652A CN 201610906122 A CN201610906122 A CN 201610906122A CN 106561652 A CN106561652 A CN 106561652A
- Authority
- CN
- China
- Prior art keywords
- isosakuranetin
- kaempferide
- weight
- ratio
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an isosakuranetin containing sterilizing combination. The isosakuranetin containing sterilizing combination comprises isosakuranetin and kaempferide, wherein the ratio of the isosakuranetin to the kaempferide is 1:1 to 20:1 based on parts by weight. Discovery shows that the isosakuranetin and the kaempferide have great synergistic preventing and treating effects on anthracnose under a specific ratio and particularly have a very remarkable synergistic effect when the ratio of the isosakuranetin to the kaempferide is between 15:1 and 19:1 based on the parts by weight.
Description
Technical field
The present invention relates to a kind of medicament, specifically a kind of bactericidal composition containing isosakuranetin, belong to agricultural technology field.
Background technology
Isosakuranetin (CAS 480-43-3) is present in many middle natural plants, with certain bactericidal action.Structural formula
It is as follows：
Kaempferide (CAS 491-54-3) source is plant origin：Zingiberaceous plant Rhizoma Kaempferiae Kaempferia galanga L.
Rhizome, Berberidaceae plant Rhizoma et Radix Diphylleiae Diphylleia sinensis Li. rhizomes, the white Ganoderma Thesium of sandalwood plants
Chinense Turcz. herbs, euphorbia plant Herba euphorbiae lunulatae Euphorbia lunulata Bge. aerial partss, leguminous plant
The dry mature fruit of Sophora japonica L. Sophora japonica L..Kaempferide is to staphylococcus aureuses and Bacillus typhi, green pus bar
Bacterium, dysentery bacterium etc. have inhibitory action.There is the inflammation effect for suppressing rat implantation Pilus Caprae seu Oviss ball.Kaempferide contains multiple phenol hydroxyls
Base, and with stronger antioxidation.Rhizoma Kaempferiae extract has inhibitory action to many human chitinases, as suppressed tryrosinase
Activity.
Actual pesticide experience have shown that, repeats and single-minded applies a kind of reactive compound to prevent and treat harmful fungoid very
To cause the fast selective of fungal bacterial strain in the case of many, be that reduction refractory fungal bacterial strain is selectively dangerous, at present generally
Harmful fungoid is prevented and treated using the mixture of different activities compound.By the way that the reactive compound with the different mechanisms of action is entered
Row combination, can delaying drug resistance produce, reduce amount of application, cost accounting is reduced, it is found by the applicant that isosakuranetin and kaempferide are one
Coordinate under certainty ratio for the effect for preventing anthrax that there is potentiation.
The content of the invention
For the problem that above-mentioned prior art is present, it is an object of the invention to provide the Bactericidal composite containing isosakuranetin
Thing, it is to be compounded the sterilization component of two kinds of different structures, the different mechanisms of action, is expanding prevention spectrum and raising drug effect
Effective way, it is often more important that avoid or delay generation of the disease to new composition resistance.To realize the purpose of the present invention, inventor
Isosakuranetin and kaempferide are compounded, for preventing and treating the disease of crop.
To achieve these goals, the technical solution used in the present invention is：One kind includes two kinds of principle active components：Different open country
Cherry element and kaempferide.
Described isosakuranetin is with the ratio of the parts by weight of kaempferide, 1:1-20:1.
Described isosakuranetin accounts for the 1-80% of medicament gross weight with the weight sum of kaempferide.
Described bactericidal composition, said composition can be made into suspending agent, wettable powder, seed coat agent, aqueous emulsion, microemulsion
Agent, cream, granule, water dispersible granules, and can be needed to use corresponding solvent, carrier and auxiliary agent according to exploitation.
Suitable solvent, auxiliary agent include：Toluene, dimethylbenzene, dichloromethane, chloroform, paraffin, kerosene, diesel oil, first
Alcohol, ethanol, propanol, butanol, amylalcohol, Hexalin, benzyl alcohol, Ketohexamethylene, isophorone, ketopyrrolidine, ethyl acetate, acetic acid fourth
One or more combination of ester, ethylene acetate, dimethyl sulfoxide etc..
Carrier include clay, bentonite, attapulgite, calcium sulfate, precipitated calcium carbonate, sucrose, industrial chitin, silica gel,
One or more combination of Pulvis Talci, white carbon, sericite in powder etc.；
Available auxiliary agent includes phosphoric acid salt, hydrochloric acid salt, lignosulphonateses, naphthalenesulfonate, phenolsulfonate
Class, succinic acid Sulfonateses, polystyrene-based phenol polyethenoxy ether sulfate, Pluronic PE 6800, molecular weight are 20000-
30000 macromolecular grafted copolymer, triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether, polystyrene-based phenol polyethenoxy
Ethers, NPE class, polystyrene-based polyethenoxy ether class, alkyl naphthalene sulfonic acid salt, aliphatic alcohol polyethenoxy
Ethers, dialkyl succinylsuccinate Sulfonateses, branched fatty alcohol polyethenoxy ether class, alkyl polyoxyethylene ether class, carboxyl alkyl cellulose
Class, hydroxy alkyl cellulose class, Magnesiumaluminumsilicate, xanthan gum, poly- alkyl silicon ethylene oxide, phosphoric acid, glacial acetic acid, citric acid, suitable fourth
One kind in enedioic acid, dibutyl hydroxy methane, Butylated hydroxyanisole, tert-butylhydroquinone, propylgallate etc. or
Multiple combination.
The present invention under specific ratio by isosakuranetin and kaempferide compatibility by having found there is collaboration preventing and treating well
The effect of anthrax, the particularly ratio in isosakuranetin and the parts by weight of kaempferide are 15:1-19:Between 1, its collaboration preventing and treating
Anthrax effect is apparent, and toxicity is less.
Specific embodiment
Embodiment 1
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 15:1,
Described isosakuranetin accounts for the 15% of medicament gross weight with the weight sum of kaempferide, NPE class
7%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 7%, remaining water complements to 100%.
Embodiment 2
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 10:1,
Described isosakuranetin accounts for the 15% of medicament gross weight with the weight sum of kaempferide, NPE class
7%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 7%, remaining water complements to 100%
Embodiment 3
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 9:1,
Described isosakuranetin accounts for the 15% of medicament gross weight with the weight sum of kaempferide, NPE class
7%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 7%, remaining water complements to 100%.
Embodiment 4
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 8:1,
Described isosakuranetin accounts for the 15% of medicament gross weight with the weight sum of kaempferide, NPE class
7%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 7%, remaining water complements to 100%.
Embodiment 5
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 5:1,
Described isosakuranetin and the weight sum of kaempferide account for the 15% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 6
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 2:1,
Described isosakuranetin accounts for the 15% of medicament gross weight with the weight sum of kaempferide, branched fatty alcohol Polyethylene oxide
Ethers 9%, Polyethylene oxide (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 7
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 1:1,
Described isosakuranetin accounts for the 15% of medicament gross weight with the weight sum of kaempferide, NPE class
7%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 7%, remaining water complements to 100%.
Embodiment 8
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 1:2,
Described isosakuranetin and the weight sum of kaempferide account for the 15% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 9
Isosakuranetin is with the ratio of the parts by weight of kaempferide, 1:6,
Described isosakuranetin and the weight sum of kaempferide account for the 15% of medicament gross weight, methyl oleate 1%, polyoxy second
Alkene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Laboratory test：
Subjects：Anthrax pathogenic bacteria
According to the incidence of the whole strain blade of test grade scale investigation Fructus Luffae, disease index and prevention effect are calculated.Will
Prevention effect is converted into niqueMin (y), and medicinal liquid does height (μ g/ml) and is converted into logarithm value (x), and with method of least square virulence is calculated
Concentration EC50 in equation and suppression, according to the abundant methods of Sun Yun toxicity index level co-toxicity coefficient (CTC) of medicament is calculated.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agents EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition co-toxicity coefficient (CTC) of middle B=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] *
100CTC≤80, compositionss show as antagonism, 80 ＜ CTC ＜ 120, and compositionss show as summation action, CTC >=120, group
Compound shows as potentiation.
The isosakuranetin of table 1：Kaempferide and its different ratio are compounded to anthrax toxicity test interpretation of result.
A is isosakuranetin, and B is kaempferide
| Reagent treatment | ATI | TTI | Co-toxicity coefficient CTC |
| A：B(20:1) | 80.1 | 82.9 | 96.6 |
| A：B(19:1) | 206.4 | 80.5 | 256.4 |
| A：B(15:1) | 187.2 | 77.4 | 241.9 |
| A：B(10:1) | 77.1 | 76.1 | 101.3 |
| A：B(5:1) | 70.9 | 74.8 | 94.8 |
| A：B(3:1) | 77.3 | 72.1 | 87.9 |
| A：B(1:1) | 60.3 | 68.6 | 87.9 |
| A：B(1:6) | 62.1 | 60.2 | 103.1 |
From the measurement result of table 1, work as isosakuranetin：Kaempferide proportioning is 15:1-19:When between 1, co-toxicity coefficient is equal
It is much higher than 200, with obvious potentiation, and other ratios mix, and co-toxicity coefficient is not obvious.
Field efficacy checking test
Test method：At the initial stage of a disease, first time spraying being carried out immediately, second dispenser being carried out after 7 days, each processes 4
Individual cell, each square meter of cell 20.10 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell is random
Sampling, 5 plants of crops of per investigation, investigates the lesion area in whole strain per blade and accounts for the percentage rate of blade area and be classified, and calculates
Disease index and prevention effect.
Expected preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-215% of leaf area；
7 grades：Leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and lesion area accounts for more than the 50% of leaf area or full leaf is withered.
The field control effectiveness test of embodiment and matched group to anthrax.
| Process group | Dosage (a.i.g/hm2) | Prevention effect (%) |
| A：B(20:1) | 60 | 56.5 |
| A：B(19:1) | 30 | 88.2 |
| A：B(19:1) | 60 | 95.3 |
| A：B(15:1) | 60 | 92.1 |
| A：B(10:1) | 60 | 52.4 |
| A：B(5:1) | 60 | 47.1 |
| A：B(1:1) | 60 | 43.6 |
| A：B(1:5) | 60 | 42.3 |
| A：B(1:10) | 60 | 41.5 |
| A | 60 | 51.7 |
| B | 60 | 32.6 |
It can be seen that embodiment 1 has significant preventing and treating anthrax effect, it is seen that isosakuranetin is with kaempferide in a definite proportion
The lower proportioning collaboration preventing and treating anthrax effect of example is apparent, and single isosakuranetin has certain prevention effect, but
Effect is not notable, and single kaempferide prevention and control capability is also effect on driving birds is not good.Isosakuranetin is with the ratio of the parts by weight of kaempferide
15:1-18:Synergy is most notable when 1, and effect is not very notable during other proportions.
Claims (3)
1. a kind of bactericidal composition containing isosakuranetin, it is characterised in that comprising two kinds of principle active components：Isosakuranetin and mountain
It is how plain.
2. a kind of bactericidal composition containing isosakuranetin according to claim 1, described isosakuranetin and kaempferide
The ratio of parts by weight is 1:1-20:1.
A kind of bactericidal composition containing isosakuranetin according to claim 1, it is characterised in that it is characterized in that effectively into
Divide and account for the 1%～90% of gross weight.
3. a kind of bactericidal composition containing isosakuranetin according to claim 1, it is characterised in that said composition can be made into
Suspending agent, wettable powder, seed coat agent, aqueous emulsion, microemulsion, cream, granule, water dispersible granules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610906122.6A CN106561652A (en) | 2016-10-17 | 2016-10-17 | Isosakuranetin containing sterilizing combination |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610906122.6A CN106561652A (en) | 2016-10-17 | 2016-10-17 | Isosakuranetin containing sterilizing combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106561652A true CN106561652A (en) | 2017-04-19 |
Family
ID=58533194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610906122.6A Pending CN106561652A (en) | 2016-10-17 | 2016-10-17 | Isosakuranetin containing sterilizing combination |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106561652A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007119429A (en) * | 2005-10-31 | 2007-05-17 | Ichimaru Pharcos Co Ltd | Activator of peroxisome proliferator-activated receptor |
| CN101518262A (en) * | 2009-03-20 | 2009-09-02 | 温州医学院 | Revulsant composition for promoting formation of mycorrhizas homobium of orchid and preparation method thereof |
| CN103536615A (en) * | 2013-11-08 | 2014-01-29 | 中国药科大学 | Preparation method of didymin and isosakuranetin, and application thereof in anti-diabetic medicine |
| CN103548851A (en) * | 2013-10-31 | 2014-02-05 | 浙江农林大学天目学院 | Biogenic controlled-release sterilization liquid and preparation method and application thereof |
-
2016
- 2016-10-17 CN CN201610906122.6A patent/CN106561652A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007119429A (en) * | 2005-10-31 | 2007-05-17 | Ichimaru Pharcos Co Ltd | Activator of peroxisome proliferator-activated receptor |
| CN101518262A (en) * | 2009-03-20 | 2009-09-02 | 温州医学院 | Revulsant composition for promoting formation of mycorrhizas homobium of orchid and preparation method thereof |
| CN103548851A (en) * | 2013-10-31 | 2014-02-05 | 浙江农林大学天目学院 | Biogenic controlled-release sterilization liquid and preparation method and application thereof |
| CN103536615A (en) * | 2013-11-08 | 2014-01-29 | 中国药科大学 | Preparation method of didymin and isosakuranetin, and application thereof in anti-diabetic medicine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102484993B (en) | Synergistic pesticide composition of matrine and tea saponin | |
| CN101999356B (en) | Sterilization composition containing fluopicolide and metalaxyl and application thereof | |
| CN103444729A (en) | Bactericidal pharmaceutical composition and applications thereof | |
| CN104222116A (en) | Saisentong-containing agricultural bactericidal composition | |
| CN103918658A (en) | Compound bactericide composition containing cyazofamid | |
| CN108812707B (en) | Thrips killing plant essential oil composition, preparation and application thereof | |
| CN106561652A (en) | Isosakuranetin containing sterilizing combination | |
| CN106561684A (en) | Bactericidal composition containing podophyllotoxin | |
| CN108477187A (en) | A kind of bactericidal composition containing psoralen and coumoxystrobin | |
| CN106561671A (en) | Tulathromycin-containing sterilization composition | |
| CN101669479B (en) | Mite-killing combination | |
| CN102696682B (en) | Wanlongmycin dimethomorph suspending agent, preparation method thereof and application | |
| CN104770380A (en) | Tetramycin and difenoconazole containing sterilizing aqueous agent and preparation method thereof | |
| CN110999922A (en) | Pesticide composition containing fructus psoraleae seed extract | |
| CN106550942A (en) | A kind of bactericidal composition containing 1,8 cineoles | |
| CN108669079A (en) | It is a kind of to be used to prevent Boscalid and eugenol compound pesticide preparation of eliminating vegetable botrytis and preparation method thereof | |
| CN102396483B (en) | Antibacterial composition | |
| CN114190392B (en) | Sterilization composition containing difenoconazole and ketoconazole and application thereof | |
| CN107156156A (en) | A kind of bactericidal composition | |
| CN102805093A (en) | Sterilization composition containing dimoxystrobin and prochloraz | |
| CN107980777A (en) | A kind of bactericidal composition containing bromothalonil and eugenol | |
| CN104585180B (en) | A kind of Pesticidal combination of containing pyriminostrobin | |
| CN106561674A (en) | Bactericidal composition containing isothiazolinone | |
| CN106962349A (en) | A kind of antiviral composition containing eugenol and lentinan | |
| CN101690488A (en) | Bactericidal composition for agricultural land |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170419 |