CN106552323A - For the beam-shaping body of neutron capture treatment - Google Patents
For the beam-shaping body of neutron capture treatment Download PDFInfo
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- CN106552323A CN106552323A CN201510643065.2A CN201510643065A CN106552323A CN 106552323 A CN106552323 A CN 106552323A CN 201510643065 A CN201510643065 A CN 201510643065A CN 106552323 A CN106552323 A CN 106552323A
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Abstract
A kind of beam-shaping body for neutron capture treatment, the beam-shaping body includes beam entrance, target, the slow body for being adjacent to target, is enclosed in the slow external reflector and beam outlet, and the slow body can be changed to adjust slow ability of the slow body to neutron.The beam-shaping body of the application neutron capture treatment only needs to select the slow body of different materials to be adjusted the slow ability of neutron the actual requirement of the indexs such as beam neutron energy range, neutron beam flux according to tumour, can be being treated to different patients using same Medical Devices, simple structure, strong applicability.
Description
Technical field
The present invention relates to a kind of beam-shaping body, more particularly to a kind of beam-shaping body for neutron capture treatment.
Background technology
With the development of atomics, such as radiation cure such as cobalt 60, linear accelerator, electron beam has become cancer and has controlled
One of Main Means for the treatment of.But conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, tumour is being killed
While cell, also substantial amounts of normal structure in beam approach can be damaged；It is sensitive to radioactive ray additionally, due to tumour cell
The difference of degree, traditional radiation therapy is for the malignant tumour for relatively having radiation resistance (such as：Multirow glioblastoma
(glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often not good.
In order to reduce the radiation injury of tumour surrounding normal tissue, the target therapy concept in chemotherapy (chemotherapy) is just
It is applied in radiation cure；And be directed to the tumour cell of radiation resistance, at present also actively development with high Relative biological effect
The radiation source of (relative biological effectiveness, RBE), such as proton therapeutic, heavy particle therapy, neutron capture is answered to control
Treat etc..Wherein, neutron capture treatment is with reference to above two concept, such as boron neutron capture treatment, by boracic medicine swollen
The specificity of oncocyte is gathered, and coordinates accurately neutron beam regulation and control, there is provided select than the more preferable treatment of cancer of conventional radiation.
Boron neutron capture treatment (Boron Neutron Capture Therapy, BNCT) be using boracic (10B) medicine is to hankering
Son has the characteristic of high capture cross section, by10B(n,α)7Li neutron captures and nuclear fission reaction are produced4He and7Two heavy burden electrochondrias of Li
Son.With reference to Fig. 1, the schematic diagram of boron neutron capture reaction is it illustrates, the average energy of two charged particles is about 2.33MeV, had
Linear energy transfer and the range for having High Linear transfer (Linear Energy Transfer, LET), short range feature, α particles is distinguished
For 150keV/ μm, 8 μm, and7Li heavy burdens particle is then 175keV/ μm, 5 μm, and the integrated range of two particle is approximately equivalent to one
Cell size, therefore for the radiation injury that organism is caused can be confined to cell level, be gathered in when boracic drug selectivity
In tumour cell, appropriate neutron of arranging in pairs or groups penetrates source, just can reach local on the premise of not normal tissue causes too major injury
Kill the purpose of tumour cell.
Because the effect of boron neutron capture treatment depends on tumour cell position boracic drug concentration and hankers quantum count, therefore it is otherwise known as
Binary radioactive ray treatment of cancer (binary cancer therapy)；It follows that except the exploitation of boracic medicine, neutron is penetrated source and is led to
The improvement of amount and quality occupies key player in the research that boron neutron capture is treated.
However, the beam-shaping body design of boron neutron capture treatment mostly is monoblock type fixed structure, such beam in prior art
The neutron beam quality of shaping body output is often fixation, but the requirement during actual therapeutic, to neutron beam quality
It is not machine-made.Different patients, the species of the position, the depth and tumour of tumour are possible to difference, and this will
Cause requirement to neutron beam quality over the course for the treatment of different, and in prior art monoblock type fixed structure beam-shaping body
The quality of neutron beam cannot be adjusted according to the concrete condition of sufferer tumour to coordinate the actual conditions of patient to treat.
Therefore, it is necessary to provide a kind of new technical scheme to solve the above problems in fact.
The content of the invention
In order to solve the above problems, one aspect of the present invention provides a kind of beam-shaping body for neutron capture treatment, described
Beam-shaping body includes beam entrance, target, the slow body for being adjacent to target, is enclosed in the slow external reflector and penetrates
Beam is exported, the target with there is nuclear reaction from the incident proton beam of the beam entrance to produce neutron, the slow body will be from
The neutron that the target is produced is slow, and the neutron that the reflector will deviate from is back to the slow body improving epithermal neutron beam
Intensity, the slow body can be changed to adjust slow ability of the slow body to neutron.
Further, the slow body includes positioned at the basal part at target rear and with basal part split the school extension for arranging, described
School extension can be individually replaced to adjust slow ability of the slow body to neutron.
Further, the basal part is adjacent to target rear and is fixed with target, and the school extension is installed on the rear of basal part
And it is adjacent to basal part.
Further, the school extension at least includes the first school extension and the second school extension, and first school extension is installed on substrate
Portion rear is simultaneously adjacent to basal part, and the second school extension is installed on the first school extension rear and is adjacent to the first school extension, and described first
School extension and the second school extension can be individually replaced.
Further, the reflector correspondence school extension offers the guide groove for extending to basal part rear, and the guide groove is provided with cunning
Rail, the school extension are moved to basal part rear by slide rail after being installed in guide groove and are adjacent to basal part；The guide groove is at least
Including corresponding with the first school extension the first guide groove and with the second school extension relative to the second guide groove；When first school extension
When only material identical with the physical dimension of the second school extension is different, the first school extension and the second school extension may be mounted at first respectively
In guide groove or the second guide groove；When the physical dimension of the first school extension and the second school extension is different and material is also different, described the
One school extension is installed in the first guide groove, and second school extension is installed in the second guide groove.
Further, reflector also includes on the outside of school extension two and is installed on the supplementary reflector in guide groove, when school extension leads to
When crossing slide rail and being installed on the rear of basal part, supplement the neutron of reflector and the reflector that is enclosed in outside basal part jointly to scattering and enter
Row reflection.
Further, the reflector is provided with rotary shaft, and the rotary shaft is provided with positioned at basal part rear and can opposed substrate portion
The rotating disk of rotation, the school extension to basal part rear and are adjacent to basal part with dial turning motion after being installed in rotating disk；Institute
Stating rotating disk at least includes first rotating disk corresponding with the first school extension and second rotating disk corresponding with the second school extension；When described
When the identical only material of the physical dimension of the first school extension and the second school extension is different, the first school extension and the second school extension respectively can be with
In the first rotating disk or the second rotating disk；When the physical dimension of the first school extension and the second school extension is different and material is also different
When, first school extension is installed in the first rotating disk, and second school extension is installed in the second rotating disk.
Further, reflector also includes the supplementary reflector located at school extension periphery, is installed on when school extension is rotated around rotary shaft
During basal part rear, supplement neutron of the reflector with the reflector being enclosed in outside basal part jointly to scattering and reflect.
Further, the material of the basal part, the first school extension and second school extension all can by Al, Pb, Ti, Bi,
C、D2O、AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3In any one or a few make.
Further, the reflector is made up of at least one in Pb or Ni, the material of the supplementary reflector and reflection
The material of body is identical.
Compared with prior art, the application has the advantages that：The application is used for the beam-shaping body of neutron capture treatment will
Slow body is designed to basal part and school extension, two parts that school extension is set to change, during actual therapeutic,
Changed with reference to the school extension of the concrete state of an illness (depths of patient tumors) the selection different materials of patient, so that slow body
Neutron beam is carried out slowly, so as to obtain being adapted to the neutron beam quality that is actually needed over the course for the treatment of of patient, simple structure,
Use flexibly.
Description of the drawings
Fig. 1 is boron neutron capture reaction schematic diagram；
Fig. 2 is the structural representation of the beam-shaping body that the application is used for neutron capture treatment；
Fig. 3 is the structural representation that guide groove installs school extension used in the application embodiment one；
Fig. 4 is the structural representation that rotating disk installs school extension used in the application embodiment two.
Specific embodiment
Neutron capture treats the application as a kind of means of effective treating cancer in recent years gradually to be increased, wherein being caught with boron neutron
Obtain and treat most commonly seen, the neutron for supplying the treatment of boron neutron capture can be supplied by nuclear reactor or accelerator.The enforcement of the application
By taking the treatment of accelerator boron neutron capture as an example, the basic module of accelerator boron neutron capture treatment is generally included for band electrochondria example
Accelerator, target and hot removal system and beam-shaping body that sub (such as proton, deuteron etc.) is accelerated, wherein accelerating band
Charged particle produces neutron with metal targets effect, according to required neutron yield rate and energy, available acceleration charged particle energy
Suitable nuclear reaction is selected with the characteristic such as size of current, the materialization of metal targets, the nuclear reaction for often coming into question has7Li(p,n)7Be
And9Be(p,n)9B, both reactions are all the endothermic reaction.The energy threshold of two kinds of nuclear reactions be respectively 1.881MeV and
2.055MeV, due to the epithermal neutron that the preferable neutron source of boron neutron capture treatment is keV energy grades, if using energy in theory
Amount is only slightly taller than the proton bombardment lithium metal target of threshold values, can produce the neutron of relative low energy, be not necessary to too many slow process and just may be used
For clinic, but two kinds of targets of lithium metal (Li) and beryllium metal (Be) are not high with the proton-effect section of threshold values energy, are
Produce sufficiently large neutron flux, generally from higher-energy proton causing nuclear reaction.
Preferably target should possess high neutron yield rate, the neutron energy distribution of generation is close to epithermal neutron energy area, nothing and wears by force spoke too much
Penetrate the characteristics such as generation, the cheap easily operated and high temperature resistant of safety, but actually and cannot find and meet required nuclear reaction,
Target made by lithium metal is adopted in embodiments of the invention.But well known to those skilled in the art, the material of target can also
It is made up of other metal materials in addition to the above-mentioned metal material talked about.
Requirement for hot removal system is then different according to the nuclear reaction for selecting, such as7Li(p,n)7Be is because of metal targets (lithium metal)
Fusing point and thermal conductivity coefficient it is poor, the requirement to hot removal system just compared with9Be(p,n)9B is high.Adopt in embodiments of the invention7Li(p,n)7The nuclear reaction of Be.
In addition, during son captures treatment technology actual therapeutic in use, the concrete condition (position of tumour of different patient tumors
Put, the species of the depth and tumour) may be different, therefore the neutron beam quality produced after there is nuclear reaction with target to proton
Specific requirement (the concrete scope of beam neutron energy range, neutron beam flux even front tropism of neutron beam etc.) may be different.
In order that during making neutron capture treatment technology more flexibly more accurately apply to the actual therapeutic of tumor patient, or even
Apply in a greater variety of oncotherapies, the application proposes to improve to the beam-shaping body for neutron capture treatment.As one
Plant preferably, be the improvement for the beam-shaping body for the treatment of accelerator boron neutron capture.
Fig. 2 to Fig. 4 is the beam-shaping body 10 in the application for neutron capture treatment, and the firing rate shaping body 10 includes beam
Entrance 11, target 12, the slow body 13 for being adjacent to target 12, the reflector 14 being enclosed in outside slow body 13 and beam outlet
17.By accelerator by proton accelerate (beamacceleration), proton beam accelerates to and be enough to overcome target atom nuclear force the treatment of accelerator boron neutron capture
Energy, occur with target 127Li(p,n)7To produce neutron (with reference to Fig. 1), the neutron of generation is through slow body for Be nuclear reactions
13 slow down, and the neutron of scattering is reflected back on beam axis by reflector 14 and is projected from beam outlet 17 again.
The making material of slow body 13 can have various, and the material of slow body 13 is to beam neutron energy range, neutron beam flux
Even before neutron beam, these indexs of tropism all have a great impact, thus the application by slow body 13 be arranged to can with replaceable,
The feelings of neutron capture treatment cannot be carried out using same Medical Devices (including the position depth, type) to solve different tumor presences
Condition.
Slow body 13 includes that basal part 131 and school extension 132, basal part 131 and school extension 132 are split-type structural.It is so-called
Split-type structural refer to that basal part 131 is located at 12 rear of target, and school extension 132 is installed on 131 rear of basal part.Substrate
Portion 131 could be arranged to changeable type, may be alternatively provided as fixed.When basal part 131 is changeable type, can be to substrate
Portion 131 and school extension 132 are changed respectively；When basal part 131 is fixed, only school extension 132 is changed.
It is of course also possible to basal part 131 and school extension 132 are arranged to into monoblock type, for different tumor presences, to whole slow
Body 13 is changed to change the slow ability of slow body 13.
In the present embodiment, the basal part 131 for adopting and school extension 132 are for split-type design, and basal part 131 is fixation
Formula.The basal part 131 of slow body 13 is arranged on the rear of target 12 and is adjoined with target 12 and is fixed, school extension 132 is installed
At the rear of basal part 131 and it is adjacent to basal part 131 (school extension 132 can not be adjacent to substrate in other embodiments
Portion 131 and make to leave gap between basal part 131 and school extension 132).In the present embodiment, school extension 132 at least includes
First school extension 133 and the second school extension 134.First school extension 133 is adjacent to 131 rear of basal part, the second school extension 134
133 rear of the first school extension is adjacent to, so that school extension 132 forms stacked, first school extension 133 of two structures
It can be individually replaced with the second school extension 134 respectively.It is pointed out that because the material for making slow body 13 has various, can
So that school extension 132 is arranged to the stacked of two or more (three, four, five more) multiple structures, with more
Fine change the slow ability of slow body, realize demand more accurate to neutron beam quality, so as to improve for different swollen
The therapeutic effect of knurl.
How to realize changing the school extension 132 of slow body 13 under lower mask body introduction.
Referring once again to Fig. 3, structural representations of the Fig. 3 for the application embodiment one.Guide groove 141 is opened up on reflector 14,
Be provided with slide rail 142 in guide groove 141, school extension 13 be installed in guide groove 141 after with the sliding motion of slide rail 142 to basal part 132
Rear simultaneously adjoins fixation with basal part 132.Guide groove 141 at least includes first guide groove 143 corresponding with the first school extension 133
And second guide groove 144 corresponding with the second school extension 134.When slow body 13 overall structure be cylinder, the first school extension
133 it is identical with the physical dimension of the second school extension 134 when, as long as the neutron beam quality requirements that obtain as needed select different
First school extension 133 of material and the second school extension 134 are arranged in the first guide groove 143 or the second guide groove 144.
That is, in this case, because the first school extension 133 is identical with the physical dimension of the second school extension 134, as long as
The material of the school extension 132 in the first guide groove 143 and the second guide groove 144 enables to what is obtained after slow body 13
Neutron beam quality can reach expected requirement, and to what is installed in the first guide groove 143 and in the second guide groove 144 be actually
First school extension 133 or the second school extension 134 be not restricted.When the overall structure of slow body 13 is cylinder, Huo Zheyuan
Cone or be cylinder and cone combination, and the first school extension 133 is different with the physical dimension of the second school extension 134
When, the neutron beam quality requirements for obtaining as needed select first school extension 133 and the second school extension 134 of different materials,
First school extension 133 correspondingly can only be installed in the first guide groove 143, and the second school extension 134 also can only correspondingly be installed on second and lead
In groove 144.
Reflector 14 also includes located at 131 liang of outsides of school extension and is installed on the supplementary reflector 145 in guide groove 141.Supplement anti-
Beam 145 can be installed on after being integrally formed with school extension 131 in guide groove 141, it is also possible to be installed in school extension 131
Individually it is respectively arranged in guide groove 141 after in guide groove 141.When school extension 131 is installed on basal part 132 by slide rail 142
Rear when, the 14 common neutron to scattering of reflector for supplementing reflector 145 and being enclosed in outside basal part 131 reflects,
So that the neutron of scattering is reflected back toward on neutron beam main shaft, to improve the intensity of beam of epithermal neutron.
Referring once again to Fig. 4, structural representations of the Fig. 4 for the application embodiment two.In embodiment two, with embodiment party
One identical part of formula is using the numeral mark same with embodiment one.One is arranged on reflector 14 with slow body 13
The rotary shaft 15 of the centerline parallel of basal part 131, rotary shaft 15 are provided with positioned at 131 rear of basal part and can opposed substrates
The rotating disk 146 that portion 131 rotates.School extension 132 is rotated to basal part 131 around rotary shaft 15 with rotating disk after being installed on rotating disk 146
Rear simultaneously adjoins fixation with basal part 131.Rotating disk 146 at least includes first rotating disk 147 corresponding with the first school extension 133
And second rotating disk 148 corresponding with the second school extension 144.When slow body 13 overall structure be cylinder, the first school extension
133 it is identical with the physical dimension of the second school extension 134 when, as long as the neutron beam quality requirements that obtain as needed select different
First school extension 133 of material and the second school extension 134 are arranged in the first rotating disk 147 or the second rotating disk 148.
In this case, because the first school extension 133 is identical with the physical dimension of the second school extension 134, as long as being arranged on first
The material of the school extension 132 in rotating disk 147 and the second rotating disk 148 enables to the neutron beam product obtained after slow body 13
Matter can reach expected requirement, and be the first school extension 133 actually to what is installed in the first rotating disk 147 and the second rotating disk 148
Or the second school extension 134 is not required.When the overall structure of slow body 13 is cylinder, or cone or be round
During the combination of cylinder and cone, when the first school extension 133 is different with the physical dimension of the second school extension 134, obtain as needed
The neutron beam quality requirements for obtaining select first school extension 133 and the second school extension 134 of different materials, the first school extension 133
Correspondingly can only be installed in the first rotating disk 147, the second school extension 134 also correspondingly can only be installed in the second rotating disk 148.
Reflector 14 also includes the supplementary reflector 145 ' located at 132 periphery of school extension, and supplementing reflector 145 ' can be with expansion
Portion 132 is installed on after being integrally formed in rotating disk 146, it is also possible to individually pacified after school extension 131 is installed on rotating disk 146
Loaded in rotating disk 146.When school extension 132 is installed on 131 rear of basal part around the rotation of rotary shaft Z, reflector 145 ' is supplemented
Reflect with the 14 common neutron to scattering of reflector being enclosed in outside basal part 131, so that during the neutron of scattering is reflected back toward
On the main shaft of sub-beam, to improve the intensity of beam of epithermal neutron.
Slow body 13 by making with the material that fast neutron action section is big, epithermal neutron action section is little, as it is a kind of preferably,
Slow body 13 is by Al, Pb, Ti, Bi, C, D2O、AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3
In at least one make, further illustrate, the basal part 131 of slow body 13 is by Al, Pb, Ti, Bi, C, D2O、
AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3In it is at least one or several make, the first school extension
133 and second the material of school extension 134 be also by Al, Pb, Ti, Bi, C, D20、AlF3、FluentalTM、CaF2、Li2CO3、
MgF2And Al2O3In at least one or several make.That is, the first school extension 133, the second school extension in the application
134 and the material of basal part 131 can be with consistent with each other, it is also possible to it is different from each other.Reflector 14 is by with neutron reflection ability
Strong material is made, and used as a kind of preferred embodiment, reflector 14 is made up of at least one in Pb or Ni.
In addition, the rear end of slow body 13 can be provided with thermal neutron absorber (not shown), set between slow body 13 and reflector 14
There is clearance channel 18, air duct 19 is provided between thermal neutron absorber and beam outlet 17, is provided with and can be subtracted in reflector 14
The radiation shield 16 of the normal tissue dose in few non-irradiated area.So-called clearance channel 18 refers to what unused solid material was covered
The empty region for easily allowing neutron beam to pass through, the clearance channel 18 could be arranged to air passage or vacuum channel.Clearance channel
18 setting can improve the flux of epithermal neutron, and the setting of air duct 19 persistently can be will deviate from neutron beam main shaft
Son leads back to main shaft to improve epithermal neutron intensity of beam.Radiation shield 16 includes the photon for shielding seepage photon in neutron beam
Shielding 161 and the neutron shield 162 to shield seepage neutron in neutron beam.Photon shielding 161 can be set with reflector 14
Set as one, it is also possible to be arranged to split type, and neutron shield 162 can be positioned adjacent to the position of beam outlet 17.
There is nuclear reaction with target 12 to produce neutron from beam entrance 11 is incident in proton beam, neutron forms neutron beam, neutron
Beam limits a beam main shaft, and the neutron beam of formation through slow body 13 by neutron degradation to epithermal neutron energy area, inhale by thermal neutron
Acceptor absorbs the thermal neutron in neutron beam, and to avoid causing multiple dose during treatment with shallow-layer normal structure, reflector 14 will be inclined
Beam main shaft is led back to improve epithermal neutron intensity of beam from the neutron of beam main shaft, penetrating for patient's treatment is best suited so as to obtain
Shu Pinzhi.
Thermal neutron absorber is made up of the material big with thermal neutron action section, used as a kind of preferred embodiment, thermal neutron absorber
By6Li makes.As one kind preferably, the material selection lead (Pb) of photon shielding 161 is made, the material choosing of neutron shield
Made with polyethylene (PE).Well known to those skilled in the art, photon shielding 161 can be made up of other materials, as long as rising
To the effect for shielding photon just, neutron shield 162 can also be made up of other materials, it is also possible to be arranged on other places, only
Disclosure satisfy that the condition of shielding seepage neutron just.
The beam-shaping body of the application neutron capture treatment only needs to refer to beam neutron energy range, neutron beam flux etc. according to tumour
Target actual requirement selects the slow body of different materials to be adjusted the slow ability of neutron, it is possible to set using same medical treatment
It is standby that different patients are treated, simple structure, strong applicability.
The beam-shaping body for neutron capture treatment that the application is disclosed is not limited to the content described in above example and attached
The represented structure of figure.Apparently change that material, shape and position on the basis of the present invention to wherein component is made,
Substitute or change, all within the scope of protection of present invention.
Claims (10)
1. it is a kind of for neutron capture treatment beam-shaping body, it is characterised in that：The beam-shaping body include beam entrance, target,
Be adjacent to the slow body of target, be enclosed in the slow external reflector and beam outlet, the target with from the beam
There is nuclear reaction to produce neutron in the incident proton beam of entrance, the slow body is slow by the neutron produced from the target, institute
Neutron that reflector will deviate from is stated back to the slow body to improve epithermal neutron intensity of beam, the slow body can be changed
To adjust slow ability of the slow body to neutron.
2. it is according to claim 1 for neutron capture treatment beam-shaping body, it is characterised in that：The slow body includes position
The school extension arranged in the basal part at target rear and with basal part split, the school extension can be individually replaced slow to adjust
Slow ability of the body to neutron.
3. it is according to claim 2 for neutron capture treatment beam-shaping body, it is characterised in that：The basal part is adjacent to
Target rear is simultaneously fixed with target, and the school extension is installed on the rear of basal part and is adjacent to basal part.
4. it is according to claim 2 for neutron capture treatment beam-shaping body, it is characterised in that：The school extension is at least wrapped
The first school extension and the second school extension are included, first school extension is installed on basal part rear and is adjacent to basal part, second expands
The portion of filling is installed on the first school extension rear and is adjacent to the first school extension, and first school extension and the second school extension can individually more
Change.
5. it is according to claim 4 for neutron capture treatment beam-shaping body, it is characterised in that：The reflector correspondence expands
The portion of filling offers the guide groove for extending to basal part rear, and the guide groove is provided with slide rail, after the school extension is installed in guide groove
Basal part rear is moved to by slide rail and basal part is adjacent to；The guide groove at least includes corresponding with the first school extension the
One guide groove and with the second school extension relative to the second guide groove；When first school extension and the physical dimension phase of the second school extension
During with only material difference, the first school extension and the second school extension are may be mounted in the first guide groove or the second guide groove respectively；When
When the physical dimension difference of the first school extension and the second school extension and also different material, first school extension is installed on first and leads
In groove, second school extension is installed in the second guide groove.
6. it is according to claim 5 for neutron capture treatment beam-shaping body, it is characterised in that：Reflector also includes being located at
On the outside of school extension two and the supplementary reflector in guide groove is installed on, when school extension is installed on the rear of basal part by slide rail,
The reflector for supplementing reflector and being enclosed in outside basal part is reflected to the neutron of scattering jointly.
7. it is according to claim 4 for neutron capture treatment beam-shaping body, it is characterised in that：The reflector is provided with rotation
Rotating shaft, the rotary shaft be provided with positioned at basal part rear and can the rotating disk that rotates of opposed substrate portion, the school extension is installed on
With dial turning motion is to basal part rear and is adjacent to basal part after in rotating disk；The rotating disk at least includes and the first school extension
The first corresponding rotating disk and second rotating disk corresponding with the second school extension；When first school extension and the second school extension
When the identical only material of physical dimension is different, the first school extension and the second school extension may be mounted at the first rotating disk or second respectively
In rotating disk；When the physical dimension difference and also different material of the first school extension and the second school extension, the first school extension peace
In loaded on the first rotating disk, second school extension is installed in the second rotating disk.
8. it is according to claim 7 for neutron capture treatment beam-shaping body, it is characterised in that：Reflector also includes being located at
The supplementary reflector of school extension periphery, when school extension is rotated around rotary shaft is installed on basal part rear, supplements reflector with bag
Neutron of the reflector being trapped among outside basal part jointly to scattering reflects.
9. it is according to claim 3 for neutron capture treatment beam-shaping body, it is characterised in that：The basal part, first
The material of school extension and second school extension all can be by Al, Pb, Ti, Bi, C, D2O、AlF3、FluentalTM、CaF2、
Li2CO3、MgF2And Al2O3In any one or a few make.
10. according to claim 5 or 7 for neutron capture treatment beam-shaping body, it is characterised in that：The reflection
Body is made up of at least one in Pb or Ni, and the material of the supplementary reflector is identical with the material of reflector.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510643065.2A CN106552323B (en) | 2015-09-30 | 2015-09-30 | Beam-shaping body for neutron capture treatment |
| CN201810275798.9A CN108325095B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
| CN201810275069.3A CN108543233B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
| CN201810275965.XA CN108355257B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
| JP2018516559A JP6722281B2 (en) | 2015-09-30 | 2016-07-12 | Beam shaper used for neutron capture therapy |
| EP16850172.4A EP3342458B1 (en) | 2015-09-30 | 2016-07-12 | Beam shaper for neutron capture therapy |
| PCT/CN2016/089731 WO2017054548A1 (en) | 2015-09-30 | 2016-07-12 | Beam shaper for neutron capture therapy |
| US15/918,262 US10898733B2 (en) | 2015-09-30 | 2018-03-12 | Beam shaping assembly for neutron capture therapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510643065.2A CN106552323B (en) | 2015-09-30 | 2015-09-30 | Beam-shaping body for neutron capture treatment |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810275965.XA Division CN108355257B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
| CN201810275798.9A Division CN108325095B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
| CN201810275069.3A Division CN108543233B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106552323A true CN106552323A (en) | 2017-04-05 |
| CN106552323B CN106552323B (en) | 2018-05-15 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810275798.9A Active CN108325095B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
| CN201810275069.3A Active CN108543233B (en) | 2015-09-30 | 2015-09-30 | Beam shaping body for neutron capture therapy |
| CN201510643065.2A Active CN106552323B (en) | 2015-09-30 | 2015-09-30 | Beam-shaping body for neutron capture treatment |
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Cited By (3)
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| CN109173083A (en) * | 2018-09-13 | 2019-01-11 | 东莞东阳光高能医疗设备有限公司 | A kind of neutron capture therapy system |
| CN112885498A (en) * | 2021-01-30 | 2021-06-01 | 散裂中子源科学中心 | Collimator used for BNCT and convenient for changing shape and size of neutron extraction pore channel |
| WO2024078353A1 (en) * | 2022-10-10 | 2024-04-18 | 中硼(厦门)医疗器械有限公司 | Beam shaping body and neutron capture therapy system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2894548A1 (en) * | 2020-08-09 | 2022-02-14 | Univ Granada | Production device, moderation and forming of neutron beams for neutron capture therapy (Machine-translation by Google Translate, not legally binding) |
| CN113724908A (en) * | 2021-08-11 | 2021-11-30 | 散裂中子源科学中心 | Thermal neutron beam shaping device |
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- 2015-09-30 CN CN201810275069.3A patent/CN108543233B/en active Active
- 2015-09-30 CN CN201510643065.2A patent/CN106552323B/en active Active
- 2015-09-30 CN CN201810275965.XA patent/CN108355257B/en active Active
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| US20070252093A1 (en) * | 2006-05-01 | 2007-11-01 | Hisataka Fujimaki | Ion beam delivery equipment and an ion beam delivery method |
| CN200998534Y (en) * | 2006-05-18 | 2008-01-02 | 深圳市华科核医疗技术有限公司 | Irradiation device for medical application |
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| CN109173083A (en) * | 2018-09-13 | 2019-01-11 | 东莞东阳光高能医疗设备有限公司 | A kind of neutron capture therapy system |
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| CN112885498A (en) * | 2021-01-30 | 2021-06-01 | 散裂中子源科学中心 | Collimator used for BNCT and convenient for changing shape and size of neutron extraction pore channel |
| WO2024078353A1 (en) * | 2022-10-10 | 2024-04-18 | 中硼(厦门)医疗器械有限公司 | Beam shaping body and neutron capture therapy system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108355257B (en) | 2020-08-07 |
| CN108325095B (en) | 2020-08-07 |
| CN108325095A (en) | 2018-07-27 |
| CN108355257A (en) | 2018-08-03 |
| CN106552323B (en) | 2018-05-15 |
| CN108543233A (en) | 2018-09-18 |
| CN108543233B (en) | 2020-08-07 |
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Application publication date: 20170405 Assignee: China Boron (Xiamen) Medical Devices Co., Ltd. Assignor: NEUBORON MEDTECH LTD. Contract record no.: X2019320000054 Denomination of invention: Beam shaping body for neutron capture therapy Granted publication date: 20180515 License type: Common License Record date: 20190910 |
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