CN106551383A - A kind of antioxidant composition of strong anti-oxidation - Google Patents
A kind of antioxidant composition of strong anti-oxidation Download PDFInfo
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- CN106551383A CN106551383A CN201510600176.5A CN201510600176A CN106551383A CN 106551383 A CN106551383 A CN 106551383A CN 201510600176 A CN201510600176 A CN 201510600176A CN 106551383 A CN106551383 A CN 106551383A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of antioxidant composition of strong anti-oxidation, with Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder as primary raw material, is aided with Lactose, Microcrystalline Cellulose, carboxymethylstach sodium, stearic acid, silicon dioxide, magnesium stearate, coating materials（Polyethylene Glycol, hypromellose）Made by health food.Its advantage is：Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder are natural plant raw material, it is ensured that the health green of product.The present invention has good oxidation-resisting health-care function, and without any side effects and untoward reaction；Product makes coated tablet, with the various features such as appearance looks elegant, taking convenience, easy to carry.
Description
Technical field
The present invention relates to a kind of antioxidant composition of strong anti-oxidation, belongs to technical field of health care food.
Background technology
Aging is a kind of successional, generally existing, progressive, inherent, and has destructive physiological process, and aging can reduce the ability that body maintains dynamic equilibrium in the face of environment-stress, the probability ill and dead so as to increase body.Affect the factor of aging a lot, wherein mainly having gene, dietetic nutrition, life style, motion, mental status and environmental factorss etc..Wherein dietetic nutrition is very important factor, and can be the factor of control.Aging phenomenon is always people's problem of interest[1].From after the forties in 20th century, the research with regard to Aging mechanism enters physiology, biochemical stage, and up to the present Chinese scholars propose nearly 300 kinds of theories or hypothesis, and wherein free radical theory is always by people's institute's common concern and approval.
Free radical is the material that body oxidation reaction is produced, also referred to as free radical, is the atom containing unpaired electron, atomic group or molecule on atomic orbital or molecular orbit.When forming molecule due to atom, in chemical bond, electronics must occur in pairs, therefore free radical will capture an electronics of other materials, make oneself to form stable material.The activity of this electron exchange is probably beneficial to the mankind, it is also possible to harmful.Activity in vivo oxygen-derived free radicals have certain function, such as immunity and signal transduction process；But excessive reactive oxygen free radical just has destruction, cause the damage of human normal cell and tissue, so as to cause various diseases.
Free radical is referred to as source of ten thousand diseases, is the main cause of human senility and disease.Free radical is mainly detrimental to health in following several respects：1. weaken the resistance of cell, make body easily by antibacterial and courses of infection；2. the chemical substance of destruction cell is produced, carcinogen is formed；3. the normal development of block cell, disturbs its return function, makes cell turnover rate less than withered rate；4. internal gene are destroyed（DNA）Tissue, upsets running and the regeneration function of cell, causes gene mutation, develop into cancer；5. destroy intracellular mitochondrion（Energy storage body）, cause to aoxidize fatigue；6. cell membrane is destroyed, the metabolism of interference cell makes cell membrane lose the function of protection cell；7. invasion cell tissue and aminoacid necessary to hormone, disturb the running of vivo system, cause vicious cycle, so that producing more polyradical, its chain reaction can cause free radical to endanger throughout whole body；8. protein is destroyed, internal enzyme is destroyed, is caused inflammation and aging；9. fat is destroyed, lipid peroxidation is made, causes atherosclerosiss, cardiovascular and cerebrovascular disease occurs；10. carbohydrate is destroyed, hyaluronic acid degradation is made, causes arthritis etc..
Free radical is ubiquitous, and which is many to approach that human body is attacked, it is existing ex vivo, also have from extraneous.Countless free radical is flooded with the environment of human survival, we are not exposed in the encirclement and attack of free radical all the time.For example, a large amount of free radicals of the generation such as the oil smoke of cooking, smoking, vehicle exhaust, industrial production waste gas, solar irradiation and medicine in people's daily life by undefended suction.Meanwhile, the free radical in the cosmetics for using can also direct aggression people skin, electronics is grabbed from epidermis cell, makes skin follow the string, coarse aging generation wrinkle.People why can aging, flag, skin tarnish and elasticity, in addition to the age is irresistible factor, main is that interior free yl is excessive, has preferable neutralized system at an early age in vivo to exclude free radical, reduces the injury caused by it；Increase however as the age, human body is repaired the ability of free radical and also declined therewith；If failing to supplement polyphenoils in time, cell begins to damage, and disease is then produced, and increasing evidence shows, interior free yl content is higher, and the life-span is shorter.Confirm at present, it is nearly all to old related degenerative disease, all there is close contact with radical damage.
One most important content of free radical life sciences is exactly to study how active oxygen jeopardizes health and the how harm to antiactive oxygen to human body.Infringement of the reactive oxygen free radical to human body is actually a kind of oxidizing process.Therefore, the infringement reduced by free radical is it is necessary to doing from antioxidation.To resist the invasion and attack of free radical, active oxygen, body is in addition to antioxidase immune system is relied on, also play a role by the nutritional labeling for removing harmful free radicals or antioxidation that has of diet intake, to maintain the balance of interior free yl, prevent and remove the generation of oxidative stress.Oxygen-derived free radicals absorbability (
ORAC) be the oxidation resistance for representing that food is total index, it represents specific food can absorb how many oxygen-derived free radicals, or inactivates which.The ORAC values of food are higher, show that the ability of its absorption oxygen-derived free radicals is stronger, just can preferably help the diseases such as human body antagonism cancer and cardiovascular diseasess.The ORAC units of 3000-5000 are taken in for each person every day, keep significant antioxidant levels in just making blood.But, due to the factor of a variety of extraneous or inside, interior free yl is unbalance, different degrees of oxidative stress occurs, or even produces certain pathological state or accelerate aging, is always difficult to avoid that.
China is a big country of world population old-age group, and according to national 9 urban parts investigation statisticses, before China old people, four common chronic diseases are hypertension, coronary heart disease, cerebrovascular and malignant tumor successively.Automatically the ability of free radical is removed in old people's body, it is more and more weaker with advancing age, cause excessive free radical to be piled up.Free radical spreads and damages any cell being in contact with it and tissue, so as to cause the disease of each organ and tissue.
Formally promulgate from the Ministry of Public Health of on June 1st, 1996《Health food management method》, country is to, since claiming that food with health role implements examination and approval system, having had approval of large quantities of health foods by health ministry and state food pharmaceuticals administration general bureau every year.Cut-off in January, 2015, the health food of 15134 approveds, wherein national OTC 14405, import health food 729 are had on the website of CFDA.Health food with anti-oxidation function has 230, accounts for the 1.5% of health food sum.
Huang Fengzhen has carried out Epidemiological study to Jinan City old people chronic disease.Respondent is the old people of 2086 65-99 year.As a result show：The prevalence of Jinan City's coronary heart disease in aged patients is 52.88%, hypertension is 49.04%, diabetes (DM) are 22.05%, hypercholesterolemia (CH) is 22.91%, and high TG mass formed by blood stasis is 24.55%, and apoplexy is 13.33%, chronic bronchitiss are 10.07%, metabolism syndrome (MS) is 20.76%, and it is 69.28% that male prostate is loose, and fatty liver is 35.38%.
The survey result of Huang Xiaohui shows that the senile chronic disease prevalence of Huang Gang communities of Shenzhen is 49.7%.It can be seen that the old people of half or so suffers from chronic disease.Modern society, rhythm of life are fast, and operating pressure is big, plus smoking, the injury drunk and radiate and pollute, internal anti-oxidation function is caused to decline, therefore supplemented with exogenous antioxidant is just particularly important, so anti-oxidation function health food market has a high potential.
Health food with anti-oxidation function mainly has：1. tablet, such as：Adopt strong board queen bee lodicule（Cai Jian apicultures company limited of Huizhou City, authentication code：The strong word G20140557 of state's food, primary raw material is Lac regis apis lyophilized powder）；Tongrentang's board natto Semen Vitis viniferae piece（Beijing Tongrentang Health Pharmaceutical Co., Ltd., authentication code：The strong word G20140484 of state's food, primary raw material is natto lyophilized powder, Semen Vitis viniferae extract）.2. capsule class, such as：Car race health board chin or cheek Yuan capsule（The magnificent pharmaceutical Co. Ltd in Sichuan Deyang, authentication code：The strong word G20140634 of state's food, primary raw material is Semen Vitis viniferae extract, Radix Astragali extract, Fructus Lycii extract, Fructus Crataegi extract）；Battledore island board anti-oxidization capsule（Dalian battledore island marine biotechnology company limited, authentication code：The strong word G20140626 of state's food, primary raw material is Stichopus japonicus powder, Semen Vitis viniferae extract, Radix Salviae Miltiorrhizae extract）.3. powder, such as：Kind that board ubiquinone10Powder（The good that health food company limited of Shanghai gold, authentication code：The strong word G20130319 of state's food, primary raw material is ubiquinone10）；Precious Austria's board Jin get Rui powder（Zhen'ao Group Corp., Ltd, authentication code：The strong word G20120543 of state's food, primary raw material is extract of Radix Ginseng leaf, tea polyphenols, marine fish skin collagen oligopeptide powder）.4. soft capsule class：Rich distant sky light board salt alga xanthophyll soft capsule（Beijing Bo Yuanxinlv Science and Technology Co., Ltd., authentication code：The strong word G20140012 of state's food, primary raw material：Algae extrats, phylloxanthin, Cera Flava, Fructus Maydis oil）；The source board soft capsule of lycopene of coloured silk（Chenguang Biological Technology Group Tianjin Co., Ltd, authentication code：The strong word G20140003 of state's food, primary raw material：Lycopene oleo-resinouss（Lycopene, soybean oil）, natural Vitamin E, soybean oil, Cera Flava）Deng.
The content of the invention
It is an object of the invention to provide a kind of can cooperate with and remove free radical, play antioxidation, the antioxidant composition of the strong anti-oxidation of delaying senility function by the raw material containing anti-oxidation function composition.
The purpose of the present invention is achieved in the following ways：
In the raw material of the health product of the present invention, the primary raw material that includes is：Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder.
By weight：10～100 parts of Semen Vitis viniferae extract, 5～30 parts of Pericarpium Citri tangerinae extract, 5～150 parts of cherry powder.
Preferably, by weight：80 parts ± 10% of Semen Vitis viniferae extract, 13 parts ± 10% of Pericarpium Citri tangerinae extract, 50 parts ± 10% of cherry powder.
The content of the Procyanidin in Grape Seed Extracts：60wt %～95 wt
%；
In the Pericarpium Citri tangerinae extract, the content of anthocyanidin is more than 25 wt %；
In the cherry powder, the content of VC is more than 16 wt
%。
Also include auxiliary material in the raw material of the health product of the present invention：Lactose, Microcrystalline Cellulose, carboxymethylstach sodium, stearic acid, silicon dioxide, magnesium stearate, by weight：356 parts ± 10% of Lactose, 52 parts ± 10% of Microcrystalline Cellulose, 14 parts ± 10% of carboxymethylstach sodium, 9 parts ± 10% of stearic acid, 2 parts ± 10% of silicon dioxide, 4 parts ± 10% of magnesium stearate.
The preparation of health product of the present invention is：Coated tablet, its coating materials is：Polyethylene Glycol and hypromellose, by weight：5 parts of Polyethylene Glycol, 10 parts of hypromellose.
The product function of the present invention is positioned at antioxidation, and by the raw material containing anti-oxidation function composition, collaboration is removed free radical, plays a part of antioxidation, slow down aging.Primary raw material Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder, are aided with Lactose, Microcrystalline Cellulose, carboxymethylstach sodium, stearic acid, silicon dioxide, magnesium stearate, coating materials（Polyethylene Glycol, hypromellose）, Jing modern processing techniques develop, develop the health food with anti-oxidation function.
Semen Vitis viniferae extract is a kind of polyphenols extracted from Semen Vitis viniferae, and its polyphenol content is more than 95%.Free phenol and polymerized polyphenolic are included in extract, by free phenol by the bonded procyanidins for forming different polymerization degree of C4-C6 or C4-C8, the degree of polymerization is lower, and non-oxidizability is stronger for polymerized polyphenolic.Semen Vitis viniferae extract has multiple biological activities, and most prominent is non-oxidizability.It is the most strong effective oxygen free radical scavenger and lipid peroxidation inhibitor for being found so far, and its oxidation resistance is 20 times of VC, 50 times of VE.
Procyanidin is the Natural Antioxidants being widely present in plant, is a general name for birdsing of the same feather flock together greatly polyphenol compound.Procyanidin is combined into by the catechin or epicatechin of varying number.Per molecule procyanidin can capture 8 oxygen-derived free radicals, and per molecule Vitamin E is only capable of capture 1, and per molecule vitamin C can capture 2.Procyanidin is removed during the ability of free radical is likely due to this kind of material molecule has electron rich hydroxylic moiety, 8 phenolic hydroxyl groups (catechin) are conjugated with double bond, for the donor of hydrogen atom, and the conjugated double bond on aromatic ring makes electronics be stablized in the molecule.2 aliphatic hydroxyls provide good aqueous solubility, exactly these molecular structure features so as to good removing free radical and antioxidative activity.
Zhao Peng has inquired into antioxidation of the grape pip powder to old rats.48 SD rats are randomly divided into 4 groups by test, it is divided into 3 dosage groups [274. 0,137. 0 and 68. 5 mg/kgBW (being respectively equivalent to 20,10 and 5 times of human body recommendation consumption)] and 1 negative control group, after continuous gavage 60 days, determine LPO in rat blood serum and liver, cerebral tissue, superoxide dismutase (
SOD) and glutathion peroxidase (GSH-Px) content, and liver, cerebral tissue lipofuscin (
Lip) content.As a result show, the grape pip powder of each dosage group can reduce LPO contents in old rats serum, reduces Lip contents and raise the GSH-Px in old rats serum and tissue
Vigor.Conclusion, grape pip powder there is antioxidation to use old rats.
Liu Yijuan have studied the anti-oxidation efficacy of Semen Vitis viniferae extract by experiment in vitro.By determining impact of the Semen Vitis viniferae extract to the ability of the clearance rate of DPPH free radicals, the clearance rate of hydroxy radical, reducing power and chelated mineral, and be compared with Natural antioxidant VC, VE, catechin, propolis and synthetized oxidation preventive agent BHT, TBHQ, PG, study Semen Vitis viniferae extract（Grape seed extract, GSE）Antioxidant activity.As a result show：GSE has the ability of stronger DPPH radical scavenging activities, reducing power and chelated mineral iron ion, and is above VE, propolis, BHT.This shows that the antioxidation mechanism of GSE is relevant with free radical, reducing power and chelated metal ions are removed.Guo Ying[9]With rats'liver, brain tissue homogenate as investigation of materials Semen Vitis viniferae extract antioxidation.Test is by each tissue homogenate, and is bathed with Semen Vitis viniferae extract altogether, then determines malonaldehyde（MDA）Growing amount.After tissue homogenate is bathed altogether with Semen Vitis viniferae extract, respectively with free yl induction agent CCl4 、H2O2 With iron ion-ascorbic acid (Fe2+- VC) lipid peroxidation is excited, produced using MDA and reduced glutathion (GSH) is exhausted as lipid peroxidation level index.As a result show, Semen Vitis viniferae extract can obviously reduce rats'liver, the generation of cerebral tissue spontaneity MDA, mitigate CCl4、H2O2、Fe2+Hepatic lipid peroxidation reaction caused by-VC, mitigates hepatic tissue GSH and exhausts.Semen Vitis viniferae extract has good lipoid peroxidization resistant.The generation for reducing lipid peroxide or the removing for accelerating peroxide, to prevent lipid peroxide to histiocytic damaging action, are conducive to the preventing and treating of slow down aging process and some illness.
Peng Liang studies antioxidation of the grape pip powder to naturally-aged rat.Test is randomly divided into 3 dosage groups and 1 negative control group, per group of 12 rats after 48 male old-age group SD rats are layered by its Serum MDA (MDA) content.3 dosage groups give 200 respectively, 100, the grape pip powder of 50 mg/kg bw, negative control group gives deionized water, and using oral administration by gavage to sample, one time a day, 90 d of continuous gavage.Then MDA in all rat bodies, lipofuscin (Lip) content and superoxide dismutase (SOD), the activity of glutathion peroxidase (GSH- Px) are determined.As a result show, the SOD and GSH-Px that grape pip powder can be significantly improved in old rats body is active, reduce internal MDA contents.
Peak has carried out antioxidative human feeding trial using Semen Vitis viniferae extract.The experimenter 120 at age 45-65 year is selected, is divided into test-meal group and matched group.Test-meal group takes given the test agent for 2 for each person every day（The content of procyanidin is about 0.1g）, continuous 3 months, matched group gave placebo by the same method.Before and after comparative experimentss, MDA, SOD, GSH-PX of experimenter improves situation.As a result show, in test-meal group serum, MDA averagely declines 4.80%；SOD averagely raises 2.31%；GSH-PX averagely raises 2.45%；Compare and the statistically significant (P of comparing difference between matched group group before and after test-meal group itself experiment< 0.01).Conclusion, has anti-oxidation function visible Grape Seed Extract Procyanidin in the range of dosage is studied.
Feng Dianjuan studies the anti-oxidation function of Semen Vitis viniferae extract with SPF level male mice in kunming as laboratory animal.Experimental evidence Mouse Weight is randomly divided into 5 groups, 10 per group, is blank group, model group and basic, normal, high 3 dosage groups respectively（0.083、0.167、0.500g/kg·bw）, blank group and the daily orally administration solvent vegetable oil of model group, continuous gavage 30d take blood and survey activities of antioxidant enzymes.Hereafter, in addition to blank, each group ray whole body disposably irradiates 5-8 Gy60Co γ, put to death animal in the 4th day after irradiation, take the difference that hepatic tissue surveys peroxide lipid content and activities of antioxidant enzymes, each dosage group of comparison and model group.As a result, superoxide dismutase in high, middle dose group mice blood（SOD）Activity, and high dose group mice blood Glutathione Peroxidase（GSH-Px）With GSH-Px, SOD activity in hepatic tissue obviously higher than model group, malonaldehyde in each dosage group Mouse Liver（MDA）Level is significantly lower than model group.Conclusion, Semen Vitis viniferae extract have the snperoxiaized effect of lipid lowering, have anti-oxidation function.
Liu Liquan inquires into impact of the grape pip procyanidin extract to aged mouse oxidation resistance, is that Semen Vitis viniferae is applied to the edible offer experimental basis of crowd.40 male Kunming kind aged mouses are randomly divided into into the basic, normal, high dosage group of matched group, Semen Vitis viniferae extract by blood MDA levels, after each group mice difference 30 d of orally administration 0.334, the 0.667, Semen Vitis viniferae extract of 2.001g/kgbw dosage and edible oil, MDA contents, SOD and GSH- Px vigor are determined.As a result show：Compare with aged controls group, high dose group can significantly reduce M DA content (P in blood<0.05) and significantly improve serum activity of SOD (P< 0.05).
Pericarpium Citri tangerinae (Bilberry), belong to Ericaceae (Ericaceae) Vaccinium (Vaccinium.SPP) perennial fallen leaves or evergreen shrubss, the whole world are widely distributed, and blue fruit Pericarpium Citri tangerinae is also known as blue berry.Containing the polyphenols such as abundant procyanidin and anthocyanin in cranberry, with antioxidation, remove plurality kinds of health care and the trophic functions such as free radical, it not only antioxidant effect it is significantly, and without any side effects to human body, now its development and application is received more and more attention.
Su Ding have studied the oxidation resistance of Pericarpium Citri tangerinae not of the same race.As a result show, cranberry not of the same race is had nothing in common with each other to the performance of DPPH free radicals, hydroxy radical, the Scavenging activity of ultra-oxygen anion free radical and reducing power.Cranberry anthocyanidin content not of the same race does not have dependency with its oxidation resistance.
Pericarpium Citri tangerinae procyanidin is acted on myocardial fibrosiies mouse model by Fan Hongyan, investigates its antioxidation to such mice.Test to the Pericarpium Citri tangerinae procyanidin of model mice continuous gavage various dose（100、200、400mg/kg·d）14 days, determine the hydroxyproline in myocardium of left ventricle tissue（Hyp）, malonaldehyde（MDA）Content and superoxide dismutase（SOD）Activity.As a result show, Pericarpium Citri tangerinae procyanidin can dose-dependently reduce Hyp, MDA content in cardiac muscular tissue, enhancement of SOD activity, and statistically significant（P<0.05 or P<0.01）.Conclusion, Pericarpium Citri tangerinae procyanidin suppress the synthesis of the propagation and collagen of Cardiac Fibroblasts, and then suppress Rat Myocardial Fibrosis by antioxidation.
Fan Ziluan is with Vaccinium vitis-idaea as object of study, its extract is studied to DPPH free radicals, ABTS free radicals, superoxide dismutase, hydroxy radical, the scavenging action of lipid peroxidation free radical, iron ion sequestering power, copper ion reducing power, while also measured were total reducing power of extract.As a result show, Vaccinium vitis-idaea extracting solution increases and enhancing with concentration to the Scavenging activity of DPPH free radicals, ABTS free radicals, superoxide dismutase, hydroxy radical, lipid peroxidation free radical, with obvious dose-effect relationship.With the increase of concentration, extracting solution increases, and has dose-effect relationship to iron ion sequestering power, copper ion reducing power.Total reducing power of Pericarpium Citri tangerinae extract, with the increase of concentration, linear rising.Conclusion, Pericarpium Citri tangerinae embody good oxidation resistance.
Lv Chunmao has investigated the anti-oxidation efficacy of Pericarpium Citri tangerinae not of the same race by experiment in vitro.The measuring reducing power of each Pericarpium Citri tangerinae, scavenging hydroxyl (OH), ultra-oxygen anion free radical (O2-) ability and the inhibitory action to DPPH free radicals.As a result show, the Pericarpium Citri tangerinae of each kind has good antioxidant activity, and antioxidant activity content is in dose-effect relationship.
Blue berry is one of Pericarpium Citri tangerinae kind, and blue berry contains abundant bioactive substance, and has different physiological roles, and which embodies outstanding role in terms of antioxidation.Zhao Juncao has inquired into the antioxidation that blue berry causes exhausted mining areas to D- galactose.In test, after mice continuous gavage 10g/kgd blue berry 6 weeks, SOD activity and the MDA contents in serum is determined.As a result show, compare with model group, blue berry group mice serum SOD activity significantly increases；And MDA contents are minimum.Conclusion, blue berry strengthen Scavenging activity of the mice to free radical, anti-lipid peroxidation.
Bao Yanqiu is tested by the removing of three kinds of free radicals：D PPH·、HO·、O2-Free radical scavenging is tested, and have studied the oxidation resistance of vaccinium oxycoccus pigment.As a result show that vaccinium oxycoccus pigment has stronger oxidation resistance, DPPH free radicals, HO free radicals and ultra-oxygen anion free radical can be removed, in the measure concentration range of experiment, clearance rate is in preferable linear relationship with concentration.69.8% is reached to the maximal clearance of DPPH free radicals, is 74.8% and 77.6% respectively to the clearance rate of HO free radicals and ultra-oxygen anion free radical, Scavenging activity is better than VC.
Wang Jian etc. is by determining vaccinium oxycoccus pigment to hydroxy radical, DPPH free radicals, H2O2, ultra-oxygen anion free radical and Fe3+Clearance rate, evaluates the oxidation resistance of vaccinium oxycoccus pigment.As a result show, vaccinium oxycoccus pigment strengthens with the increase of concentration to the clearance rate of various free radicals, ascorbic acid of its antioxidant activity higher than same concentrations.
Cherry powder used in the product of the present invention is Malpighia glabra L. powder, Malpighia glabra L. also known as west Indian cherry.Containing multivitamin mineral such as protein, fruit acid and vitamin A, B1, B2, vitamin Cs in Malpighia glabra L. fruit, wherein ascorbic content is up to 1215-3024mg/100g, it is splendid natural complex source.King's neck has investigated the non-oxidizability of west Indian cherry powder.As a result show, compared with the vitamin C of same amount, Fructus Pruni pseudocerasi water extract has higher ultra-oxygen anion free radical, hydroxy radical, DPPH radical scavenging activities.
Motion raises can interior free yl content.There is the affinity of height between unsaturated fatty acid in free radical and biomembrane, the two will generate the peroxide of unsaturated fatty acid, be destroyed biomembranous structure, function once combining, tissue is damaged, affect motion.Vitamin C can directly or indirectly eliminate free radical as natural free radical scavenger, so as to protect biological film integrality, improve body ability to work, generation of postponing or lessen fatigue[23]。
Wang Fengyun demonstrates auxiliary therapeutic action of the vitamin C to patients with cor pulmonale by clinical trial.Research shows that the free-radical contents in patients with cor pulmonale body can increase, and free radical causes injury of lung by number of ways.As a result show, after VC groups are treated 14 days, before relatively treating, MDA contents are remarkably decreased（P<0.01）.There is free radical resisting to damage for conclusion, vitamin C, protect the function of cell membrane and subcellular organelle.
In sum, antioxidant health-care product with the Semen Vitis viniferae extract rich in procyanidin, Pericarpium Citri tangerinae extract and rich in ascorbic cherry powder as primary raw material, free radical can be effectively removed, the total reducing power of body is improved, is reached the function of antioxidation, slow down aging.
Semen Vitis viniferae extract is to allow one of use and common healthy food material.It is 0.48g that this product recommends dose daily（Withdrawal ratio is 20:1）, its quality standard meets the requirement of company standard.Pericarpium Citri tangerinae extract is bread and cheese, and edible safety, this product recommend dose daily for 78mg（Withdrawal ratio 50:1）, its quality standard meets the requirement of company standard.The daily recommendation dose of procyanidin is about 307mg.Extract of the cherry powder for bread and cheese Malpighia glabra L., edible safety, this product are recommended to take 300mg daily（Withdrawal ratio is 11:1）, its quality standard meets the requirement of company standard.The processing technique of three of the above extract is traditional processing technique, and added processing aid allows the processing aid for using in being food.
It is an advantage of the invention that：Make use of the synergistic principle of three kinds of components, synergistic principle is a basic sides of best nutritional method, and team unity is strong to cross individual combat, after some nutrients leave their cooperative partner, the basic synergism that cannot just play effect, particularly antioxidant is even more important；
Complex of the present invention is made up of Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract and cherry powder.The effective ingredient of plant extract and fruit powder is carried out collocation compatibility by the present invention, cooperates with effect of each raw material, Jing special process to prepare the product with strong anti-oxidation, and product is easy to use, has no side effect safely.
Semen Vitis viniferae extract in the present invention is rich in procyanidin, and Pericarpium Citri tangerinae extract is rich in anthocyanidin, and cherry powder is rich in VC, and these three compositions all have very strong non-oxidizability, and especially procyanidin has very strong reducing/regenerating ability again to VC.By three kinds of functional components; other being rich in being aided with raw material are beneficial to the minerals and vitamins of human body; through proportion optimizing; they are combined according to appropriate proportioning; it is used in conjunction with; cooperate with mutually, obtain the anti-oxidation protection effect than individually taking several times more than these nutrients, define the exclusive anti-oxidation protection system of the present invention.Can effective guarantee human nutrition it is comprehensive and balanced, prevent the generation of various chronic diseases, the formula is ensured to greatest extent and is met the daily antioxidation demand of people.
In sum, antioxidant composition of the invention has good oxidation-resisting health-care function, and without any side effects and untoward reaction；This product makes coated tablet, with the various features such as appearance looks elegant, taking convenience, easy to carry.
Description of the drawings
Fig. 1 is the processing technology sketch of the present invention.
Specific embodiment
Embodiment：
The product of the present invention is, with Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder as primary raw material, to be aided with Lactose, Microcrystalline Cellulose, carboxymethylstach sodium, stearic acid, silicon dioxide, magnesium stearate, coating materials（Polyethylene Glycol, hypromellose）, Jing modern processing techniques develop.With reference to the characteristics of raw material and composition characteristics, using procyanidin as significant composition.The measure of procyanidin according to《Health food is checked and assessment technique specification》（Version in 2003）In " measure of health food procyanidins " method for specifying determine.Through the study on the stability of three batches of pilot products, procyanidin content is stable, quality controllable, can be used as the quality control index of product.
Product formula is shown in Table 1：
Every 595mg, is made up of following supplementary material per 1000：
Table 1
Primary raw material is required：
1. Semen Vitis viniferae extract：Prescription all should meet the regulation of table B1.
Table B1 Semen Vitis viniferae extract quality standards
2. Pericarpium Citri tangerinae extract：Prescription should meet the regulation of table B2.
B2 Pericarpium Citri tangerinae extract quality standards
3. cherry powder：Prescription should meet the regulation of table B3.
The quality standard of table B3 cherry powders
Supplementary product kind and foundation is used in the product of the present invention：
The species and consumption foundation of adjuvant used by this product are listed in table 2.
2 supplementary product kind of table and use foundation
| Name of material | Species | Effect | Using foundation |
| Lactose | Bread and cheese | Excipient correctivess | Bread and cheese, consumption safety |
| Microcrystalline Cellulose | Food additive | Disintegrating agent anticaking agents | GB2760, appropriate use is needed by production. |
| Carboxymethylstach sodium | Pharmaceutic adjuvant | Filler disintegrating agent | Pharmaceutic adjuvant, is added in right amount by technological requirement |
| Stearic acid | Food additive | Lubricant disintegrating agent | GB 2760, needs appropriate use by production |
| Silicon dioxide | Food additive | Anticaking agents | Pharmaceutic adjuvant, is added in right amount by technological requirement |
| Magnesium stearate | Food additive | Lubricant | GB 2760, needs appropriate use by production. |
| Coating materials（Polyethylene Glycol, hypromellose） | Pharmaceutic adjuvant | Coating materials | Pharmaceutic adjuvant, is added in right amount by technological requirement |
Lactose is bread and cheese raw material, its have it is compressible shaping and water absorption it is low the characteristics of, often do tableting excipients use.Excipient and correctivess are primarily served the purpose of in this product.Its quality meets GB25595《National food safety standard Lactose》Regulation.
Microcrystalline Cellulose is GB2760《Food additive uses sanitary standard》Using food additive, which has stronger adhesion and good compressibility for permission, and effect primarily serves the purpose of disintegrating agent and anticaking agents in this product better than similar adjuvant such as starch, dextrin.Its quality meets《Food additive specified value food additive Microcrystalline Cellulose》Regulation.Its consumption meets the regulation in GB2760.
Carboxymethylstach sodium is《Pharmacopeia》One of middle pharmaceutic adjuvant for allowing to use, with good water absorption and water swellability, and with good compressibility, mobility, without drawing moist, increasing tablet hardness does not affect disintegrate again.Filler and disintegrating agent are primarily served the purpose of in this product.Its quality meets《Pharmacopeia》2010 editions（Two）Regulation under " carboxymethylstach sodium " item.
Stearic acid allows to use food additive for GB 2760, and which primarily serves the purpose of lubricant and disintegrating agent, and its quality meets《Food additive specified value food additive stearic acid》Regulation.Its consumption meets the regulation in GB2760.
Silicon dioxide allows to use food additive for GB2760, and which primarily serves the purpose of anticaking agents, and its quality meets GB25576《National food safety standard food additive silicon dioxide》Regulation.Its consumption meets the regulation of GB2760.Magnesium stearate allows to use food additive for GB 2760, and which primarily serves the purpose of lubricant, and its quality meets《Food additive specified value food additive magnesium stearate》Regulation.Consumption meets the regulation in GB2760.The use of silicon dioxide and magnesium stearate effectively can solve to stick rushes phenomenon, tablet surface smooth and beautiful appearance.
Coating materials（Polyethylene Glycol, hypromellose）In the equal common medicinal supplementary material of Polyethylene Glycol and hypromellose.
In sum, each supplementary material of this product is used equally to health food, legal, consumption safety of originating, and the evaluation of Jing toxicological securities confirms edible safety, and Jing functional trials prove to effectively play oxidation-resisting health-care function.
The science of Process Route Planning, product form and dosage form selection, reasonability, feasibility and foundation：
The selection of dosage form：
Because accurately, steady quality, taking convenience are with low cost, are easy to automated machine to produce in a large number, and product hygienic quality is easily controlled for tablet dose.In view of the characteristic that has of supplementary material that this product is selected, and assimilation effect of the product expection health-care effect and human body to be reached to nutritional labeling, with reference to the distinctive equipment of production plant, most product forms are chosen to be tablet at last.
Verify that the production technology of the setting and selection of product forms is practical by trial-manufacture of sample and expanding production, while stablizing using the product quality developed by this dosage form, significant component content is stable, instant, health-care effect substantially, can be welcome and be received by consumers in general.
Process Route Planning：
In view of supplementary material characteristic in this product formula, with reference to the preparation technology flow process and production plant situation of tablet, through experimental study, it is determined that following process routes：
A. all supplementary material Jing are after the assay was approved being ready for use on production.
B. weigh：Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder, Lactose, Microcrystalline Cellulose, stearic acid, carboxymethylstach sodium are weighed by formula proportion amount.
C. mix：By Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder, Lactose, Microcrystalline Cellulose, stearic acid, formula proportion amount 50%（v/v）Carboxymethylstach sodium mix homogeneously, incorporation time is 5min, obtains mixed powder.
D. pelletize：By mixed powder and 95%（v/v）Ethanol solution mixes, and soft material is obtained.Soft material is crossed into the granulation of 20 mesh sieves, wet granular is obtained.
E. it is dried：Wet granular is dried below 60 DEG C, dry particl is obtained.
F. granulate：Dry particl is crossed into 20 mesh sieve granulate, granule is obtained.
G. it is total mixed：The granule obtained after granulate is mixed homogeneously with magnesium stearate, silicon dioxide and remaining carboxymethylstach sodium, incorporation time 20min obtains total mixture.
H. tabletting：Total mixture is carried out into tabletting, control plain piece weight 580mg/ pieces.
I. coating：By film coating agent（Polyethylene Glycol, hypromellose）In adding appropriate purified water, coating solution is made, be coated, obtain coated tablet 595mg/ pieces.
J. inner packing：Packed using bubble cap tray, 10 sheet panels.Packaging material quality should meet YBB0015《Drug packaging aluminium foil》、YBB0021《Polrvinyl chloride solid medicinal stiff sheet》Requirement.
K. outer package：Carton（3 plates/box）, carton.
L. check, put in storage：Qualified product warehousing will be checked.
In this product, primary raw material Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder are respectively provided with certain hygroscopicity and viscosity.If adopting direct powder compression, sticking head phenomenon can be caused because of moisture absorption, the reason such as be heated；And wet granulation technology is adopted, because of the tabletting again through granulation, after being dried, effectively can reduce hygroscopicity and avoid sticking head phenomenon.Additionally, good than direct powder compression in terms of hardness, friability index using the tablet of wet granulation technology, and beneficial to follow-up coating operations, so as to get coated tablet there is preferable outward appearance.Therefore, the final technique of this product is defined as wet granule compression tablet technique.
Also this point is taken into full account on adjuvant is selected, the characteristics of Lactose has compressible shaping and low water absorption, often make tableting excipients；Microcrystalline Cellulose, stearic acid are respectively provided with stronger stability, play a part of fluidizer, promote disintegrate；Carboxymethylstach sodium by inside and outside plus effectively facilitate disintegration of tablet, beneficial to absorbing；Binding agent is done using 95% ethanol solution can effectively reduce the viscosity of extract, make soft material formation single-size loosely.Lubrication is played in magnesium stearate, the addition of silicon dioxide, can effectively be solved to stick and be rushed phenomenon, tablet surface smooth and beautiful appearance.Impact of the different concentration ethanol solution to soft material viscosity by the effects, detailed results are shown in Table 3：
Impact of the 3 different concentration ethanol solution of table to soft material viscosity
| Ethanol solution concentration (v/v) | Soft material viscosity | Granulating situation |
| 50% | It is very glutinous | Strip, it is impossible to go out grain |
| 75% | Relatively stick | Strip, it is impossible to go out grain |
| 95% | Loosely | Granule is neither too hard, nor too soft, is adapted to tabletting needs |
Product design made by the method is attractive in appearance, good fluidity, wearability are compared with strong, the good advantage of compression molding.The advantage of pelletizing press sheet：1. improve material fluidity；2. prevent various composition from isolation is produced in mixed process because of the difference of granularity, density；3. avoid or reduce dust；4. bulk density is adjusted, improves dissolution and disintegrating property；5. improve the uniformity of material pressure transmission during film-making.
In the production technology of this product, the technique of most critical is the mixed processes of raw material.Because the uniformity of mixing is directly connected to the homogeneous distribution of significant composition.In test, we determine the incorporation time of total mix process by the mixing homogeneity of investigation procyanidin.9 parts are sampled from different azimuth, different depth respectively in experiment to determine procyanidin content to guarantee the representativeness of sample point, experimental result is shown in Table 4：
4 total mixed mixing homogeneity test data of table
Note：RSD is relative standard deviation.
From the results, it was seen that when incorporation time is 20,25 minutes, the relative standard deviation of procyanidin is within 5%.Consider from improve production efficiency and reduction processing cost, total incorporation time of the raw material that we choose is 20min.
Little trial production：
For checking technique, a collection of lab scale is carried out, be finally made product, and the quality controling research for product provides test specimen, is examined or check as index using procyanidin content.This lab scale uses the formula ratio of 1000, and concrete preparation method is with aforementioned.Result of the test is shown in Table 5：
5 lab scale craft result of table（1000/batches）
Conclusion：The every inspection of the made sample of lab scale meets formulation requirements, is further to verify technique if appropriate for amplification, then arranges three batches of pilot scales to be tested, and each design parameter by pilot plant test adjusting process.
Scale up test：
Prescription, technique to determination has carried out scale up test, and to investigate formula, the repeatability of technique and feasibility, result of the test is shown in Table 6：
6 scale up test result of table
Conclusion：From upper table result, average yield rate is 98.53%, and significant component content is stable, and each item data is and lab scale sample result is basically identical.Therefore pilot plant test result shows：The technique is rational, is adapted to big production.
Claims (10)
1. a kind of antioxidant composition of strong anti-oxidation, is characterized in that：The primary raw material included in the raw material for making health product is：Semen Vitis viniferae extract, Pericarpium Citri tangerinae extract, cherry powder.
2. the antioxidant composition of strong anti-oxidation according to claim 1, is characterized in that：By weight：10～100 parts of Semen Vitis viniferae extract, 5～30 parts of Pericarpium Citri tangerinae extract, 5～150 parts of cherry powder.
3. the antioxidant composition of strong anti-oxidation according to claim 1, is characterized in that：By weight：80 parts ± 10% of Semen Vitis viniferae extract, 13 parts ± 10% of Pericarpium Citri tangerinae extract, 50 parts ± 10% of cherry powder.
4. the antioxidant composition of the strong anti-oxidation according to claim 1,2,3, is characterized in that：The content of the Procyanidin in Grape Seed Extracts：60wt %～95 wt %.
5. the antioxidant composition of the strong anti-oxidation according to claim 1,2,3, is characterized in that：In the Pericarpium Citri tangerinae extract, the content of anthocyanidin is more than 25 wt %.
6. the antioxidant composition of the strong anti-oxidation according to claim 1,2,3, is characterized in that：In the cherry powder, the content of VC is more than 16 wt %.
7. the antioxidant composition of the strong anti-oxidation according to claim 2,3, is characterized in that：Also include auxiliary material in making the raw material of health product：Lactose, Microcrystalline Cellulose, carboxymethylstach sodium, stearic acid, silicon dioxide, magnesium stearate, by weight：356 parts ± 10% of Lactose, 52 parts ± 10% of Microcrystalline Cellulose, 14 parts ± 10% of carboxymethylstach sodium, 9 parts ± 10% of stearic acid, 2 parts ± 10% of silicon dioxide, 4 parts ± 10% of magnesium stearate.
8. the antioxidant composition of strong anti-oxidation according to claim 7, is characterized in that：The preparation of the health product is：Coated tablet.
9. the antioxidant composition of strong anti-oxidation according to claim 8, is characterized in that：The coating materials of the coated tablet are：Polyethylene Glycol and hypromellose, by weight：5 parts of Polyethylene Glycol, 10 parts of hypromellose.
10. the antioxidant composition of the strong anti-oxidation according to claim 1,2,3, is characterized in that：The cherry powder is Malpighia glabra L. powder.
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| CN107397697B (en) * | 2017-08-30 | 2020-05-12 | 永安康健药业（武汉）有限公司 | Whitening and freckle removing composition and application thereof |
| CN107569514A (en) * | 2017-09-30 | 2018-01-12 | 深圳靶向基因技术有限公司 | It is a kind of to target the activated complex for improving p53 expression of tumor suppressor gene |
| CN109329727A (en) * | 2018-10-26 | 2019-02-15 | 北京斯利安药业有限公司 | Antioxidant composition, anti-oxidation preparation and application |
| CN109349489A (en) * | 2018-11-16 | 2019-02-19 | 西安源森生物科技有限公司 | A kind of solid beverage and preparation method thereof with function of delaying senility |
| CN109527322A (en) * | 2018-12-21 | 2019-03-29 | 浙江尖峰健康科技有限公司 | A kind of solid beverage and preparation method thereof with fair skin function |
| CN112401090A (en) * | 2019-11-04 | 2021-02-26 | 富诺健康股份有限公司 | Anthocyanin beverage and preparation method thereof |
| CN110934209A (en) * | 2019-12-17 | 2020-03-31 | 神威药业集团有限公司 | Composition with antioxidant function, health food and preparation method thereof |
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