CN106540317A - A kind of realizing controlled-release bone cement and preparation method thereof - Google Patents
A kind of realizing controlled-release bone cement and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of realizing controlled-release bone cement and preparation method thereof, is prepared from by following component：Arizona bacilli, tricalcium phosphate, nanometer hydroxyapatite, tantalic acid calcium, phytic acid strontium, bismuth oxide, GE-cellulose, phylloxanthin, phosphatidylcholine, graphene oxide, methyl beta cyclodextrin, potassium alginate, tartaric acid, ammonium ceric nitrate, locust bean gum, phosphate buffer, malic acid.The porosity of the bone cement that the present invention is provided relatively up to 54 61%, bone conduction and bone tactophily can be promoted, Healing Rate is improved, shorten the healing therapy cycle, the comprcssive strength of the bone cement meets the application demand of clinically each side still in higher level simultaneously.Additionally, preparation method process is simple provided by the present invention and combination property is good, can large-scale production application.
Description
Technical field
The invention belongs to biology medical material technical field, and in particular to a kind of realizing controlled-release bone cement and its preparation side
Method.
Background technology
At present, be an emerging research field using bone cement as the control release carrier of medicine, medical science, biology,
Field is widely studied.Its application solves suddenly high by drug level in medicine body system produced by traditional cyclical administration mode
Suddenly it is low, be also easy to produce that toxic and side effects, drug half-life be short and the low problem of utilization ratio, medicine is maintained in by medicine body system for a long time
Valid density.At present, it is clinically conventional Bone Defect Repari drug release carrier with polymer microsphere and calcium phosphate cement composite material,
Biocompatibility is good, can promote bone tissue restoration and reconstruction, moreover it is possible to by the slow release of medicine, reaches treatment infection, cancer
The purpose of disease.However, the porosity of calcium phosphate bone cement is relatively low, lack hole connection, bone conduction effect on driving birds is not good, new bone between micropore
It is difficult to increase, affects Healing Rate；Additionally, the porosity of increase calcium phosphate bone cement often reduces the mechanical strength of material again,
Affect safety in utilization.Therefore, the realizing controlled-release bone cement material pair that a kind of suitable porosity of demand is mutually coordinated with high strength
It is significant in the clinical practice of medicine controlled release carrier.
The content of the invention
It is an object of the invention to provide a kind of realizing controlled-release bone cement and preparation method thereof, to solve at least one technology
Problem.
Technical scheme is come as follows：
A kind of realizing controlled-release bone cement, is prepared from by the component of following weight portion：Arizona bacilli 28-45 parts, tricalcium phosphate
15-26 parts, nanometer hydroxyapatite 7-14 parts, tantalic acid calcium 5-11 parts, phytic acid strontium 3-8 parts, bismuth oxide 2-7 parts, GE are fine
Dimension element 4-9 parts, phylloxanthin 2-6 parts, phosphatidylcholine 3-7 parts, graphene oxide 2-6 parts, methyl-B-cyclodextrin 4-8 parts, Sargassum
Sour potassium 3-7 parts, tartaric acid 2-6 parts, ammonium ceric nitrate 1-4 parts, locust bean gum 2-5 parts, phosphate buffer 28-44 parts, malic acid
30-47 parts.
In above-mentioned technical proposal, it is prepared from by the component of following weight portion：Arizona bacilli 32-44 parts, tricalcium phosphate 17-
24 parts, nanometer hydroxyapatite 8-13 parts, tantalic acid calcium 6-10 parts, phytic acid strontium 3.5-7 parts, bismuth oxide 2.4-6.2 parts, GE
Cellulose 4.5-7 parts, phylloxanthin 2.2-5.6 parts, phosphatidylcholine 3.8-6.2 parts, graphene oxide 2.4-5.3 parts, methyl-β-
Cyclodextrin 4.2-7 parts, potassium alginate 3.8-6.3 parts, tartaric acid 2.2-5 parts, ammonium ceric nitrate 1.6-3.7 parts, locust bean gum 2.8-
4.3 parts, phosphate buffer 30-42 parts, malic acid 33-44 parts.
In above-mentioned technical proposal, it is prepared from by the component of following weight portion：38 parts of Arizona bacilli, 21 parts of tricalcium phosphate,
12 parts of nanometer hydroxyapatite, 7.5 parts of tantalic acid calcium, 5.6 parts of phytic acid strontium, 4.8 parts of bismuth oxide, 6 parts of GE-cellulose, leaf are yellow
4.3 parts of element, 5 parts of phosphatidylcholine, 3.9 parts of graphene oxide, 5.6 parts of methyl-B-cyclodextrin, 4.8 parts of potassium alginate, tartaric acid
3.7 parts, 2.2 parts of ammonium ceric nitrate, 3 parts of locust bean gum, 38 parts of phosphate buffer, 42 parts of malic acid.
Another technical scheme of the present invention is come as follows：
A kind of preparation method of realizing controlled-release bone cement, including following preparation process：
Step 1）Add graphene oxide in malic acid, ultrasonic disperse is uniform, is subsequently adding potassium alginate, GE fiber
Element, methyl-B-cyclodextrin and locust bean gum, in 40-70 DEG C of stirring mixing 10-30min, are cooled to room temperature, obtain mixed liquor A；
Step 2）Tartaric acid, ammonium ceric nitrate, phylloxanthin and phosphatidylcholine are added in phosphate buffer, stirring mixing is equal
It is even, then with step 1）The mixed liquor A of middle preparation stirs mixing 15-40min at 50-80 DEG C, is cooled to room temperature, obtains mixed liquor
B, it is standby；
Step 3）By Arizona bacilli, tricalcium phosphate, nanometer hydroxyapatite, tantalic acid calcium, phytic acid strontium and bismuth oxide mix homogeneously,
0.5-2 hours are incubated at 180-320 DEG C, room temperature are naturally cooled to, is obtained compound C, it is standby；
Step 4）By step 2）In mixed liquid B and step 3）In compound C be uniformly mixed, obtain final product realizing controlled-release medical bone
Cement.
In above-mentioned technical proposal, step 1）In, in 65 DEG C of stirring mixing 25min.
In above-mentioned technical proposal, step 2）In, the stirring mixing 20min at 70 DEG C.
In above-mentioned technical proposal, step 3）In, 1 hour is incubated at 260 DEG C.
As a result of above technical scheme, beneficial effects of the present invention are：
The porosity of the bone cement that the present invention is provided relatively is up to 54-61%, can promote bone conduction and bone tactophily, improves
Healing Rate, shortens the healing therapy cycle, while the comprcssive strength of the bone cement is still in higher level, up to 26.5-
33.6MPa, meets the application demand of clinically each side.Additionally, preparation method process is simple provided by the present invention and synthesis
Excellent performance, can large-scale production application.
Specific embodiment
With reference to specific embodiment, the present invention is described in further detail.Following examples be used for illustrate the present invention,
But it is not limited to the scope of the present invention.
Embodiment 1
A kind of realizing controlled-release bone cement, is prepared from by the component of following weight portion：28 parts of Arizona bacilli, tricalcium phosphate 15
Part, 7 parts of nanometer hydroxyapatite, 5 parts of tantalic acid calcium, 3 parts of phytic acid strontium, 2 parts of bismuth oxide, 4 parts of GE-cellulose, phylloxanthin 2
Part, 3 parts of phosphatidylcholine, 2 parts of graphene oxide, 4 parts of methyl-B-cyclodextrin, 3 parts of potassium alginate, 2 parts of tartaric acid, cerous nitrate
1 part of ammonium, 2 parts of locust bean gum, 28 parts of phosphate buffer, 30 parts of malic acid.
A kind of preparation method of realizing controlled-release bone cement, including following preparation process：
Step 1）Add graphene oxide in malic acid, ultrasonic disperse is uniform, is subsequently adding potassium alginate, GE fiber
Element, methyl-B-cyclodextrin and locust bean gum, in 40 DEG C of stirring mixing 10min, are cooled to room temperature, obtain mixed liquor A；
Step 2）Tartaric acid, ammonium ceric nitrate, phylloxanthin and phosphatidylcholine are added in phosphate buffer, stirring mixing is equal
It is even, then with step 1）The mixed liquor A of middle preparation stirs mixing 15min at 50 DEG C, is cooled to room temperature, obtains mixed liquid B, standby
With；
Step 3）By Arizona bacilli, tricalcium phosphate, nanometer hydroxyapatite, tantalic acid calcium, phytic acid strontium and bismuth oxide mix homogeneously,
0.5 hour is incubated at 180 DEG C, room temperature is naturally cooled to, is obtained compound C, it is standby；
Step 4）By step 2）In mixed liquid B and step 3）In compound C be uniformly mixed, obtain final product realizing controlled-release medical bone
Cement.
Embodiment 2
A kind of realizing controlled-release bone cement, is prepared from by the component of following weight portion：Phosphorous acid Ca45 part, tricalcium phosphate 26
Part, 14 parts of nanometer hydroxyapatite, 11 parts of tantalic acid calcium, 8 parts of phytic acid strontium, 7 parts of bismuth oxide, 9 parts of GE-cellulose, phylloxanthin
6 parts, 7 parts of phosphatidylcholine, 6 parts of graphene oxide, 8 parts of methyl-B-cyclodextrin, 7 parts of potassium alginate, 6 parts of tartaric acid, cerous nitrate
4 parts of ammonium, 5 parts of locust bean gum, 44 parts of phosphate buffer, 47 parts of malic acid.
A kind of preparation method of realizing controlled-release bone cement, including following preparation process：
Step 1）Add graphene oxide in malic acid, ultrasonic disperse is uniform, is subsequently adding potassium alginate, GE fiber
Element, methyl-B-cyclodextrin and locust bean gum, in 70 DEG C of stirring mixing 30min, are cooled to room temperature, obtain mixed liquor A；
Step 2）Tartaric acid, ammonium ceric nitrate, phylloxanthin and phosphatidylcholine are added in phosphate buffer, stirring mixing is equal
It is even, then with step 1）The mixed liquor A of middle preparation stirs mixing 40min at 80 DEG C, is cooled to room temperature, obtains mixed liquid B, standby
With；
Step 3）By Arizona bacilli, tricalcium phosphate, nanometer hydroxyapatite, tantalic acid calcium, phytic acid strontium and bismuth oxide mix homogeneously,
2 hours are incubated at 320 DEG C, room temperature are naturally cooled to, is obtained compound C, it is standby；
Step 4）By step 2）In mixed liquid B and step 3）In compound C be uniformly mixed, obtain final product realizing controlled-release medical bone
Cement.
Embodiment 3
A kind of realizing controlled-release bone cement, is prepared from by the component of following weight portion：32 parts of Arizona bacilli, tricalcium phosphate 17
Part, 8 parts of nanometer hydroxyapatite, 6 parts of tantalic acid calcium, 3.5 parts of phytic acid strontium, 2.4 parts of bismuth oxide, 4.5 parts of GE-cellulose, leaf
2.2 parts of flavin, 3.8 parts of phosphatidylcholine, 2.4 parts of graphene oxide, 4.2 parts of methyl-B-cyclodextrin, 3.8 parts of potassium alginate, wine
2.2 parts of stone acid, 1.6 parts of ammonium ceric nitrate, 2.8 parts of locust bean gum, 30 parts of phosphate buffer, 33 parts of malic acid.
A kind of preparation method of realizing controlled-release bone cement, including following preparation process：
Step 1）Add graphene oxide in malic acid, ultrasonic disperse is uniform, is subsequently adding potassium alginate, GE fiber
Element, methyl-B-cyclodextrin and locust bean gum, in 60 DEG C of stirring mixing 18min, are cooled to room temperature, obtain mixed liquor A；
Step 2）Tartaric acid, ammonium ceric nitrate, phylloxanthin and phosphatidylcholine are added in phosphate buffer, stirring mixing is equal
It is even, then with step 1）The mixed liquor A of middle preparation stirs mixing 25min at 70 DEG C, is cooled to room temperature, obtains mixed liquid B, standby
With；
Step 3）By Arizona bacilli, tricalcium phosphate, nanometer hydroxyapatite, tantalic acid calcium, phytic acid strontium and bismuth oxide mix homogeneously,
1 hour is incubated at 250 DEG C, room temperature is naturally cooled to, is obtained compound C, it is standby；
Step 4）By step 2）In mixed liquid B and step 3）In compound C be uniformly mixed, obtain final product realizing controlled-release medical bone
Cement.
Embodiment 4
A kind of realizing controlled-release bone cement, is prepared from by the component of following weight portion：44 parts of Arizona bacilli, tricalcium phosphate 24
Part, 13 parts of nanometer hydroxyapatite, 10 parts of tantalic acid calcium, 7 parts of phytic acid strontium, 6.2 parts of bismuth oxide, 7 parts of GE-cellulose, leaf are yellow
5.6 parts of element, 6.2 parts of phosphatidylcholine, 5.3 parts of graphene oxide, 7 parts of methyl-B-cyclodextrin, 6.3 parts of potassium alginate, tartaric acid
5 parts, 3.7 parts of ammonium ceric nitrate, 4.3 parts of locust bean gum, 42 parts of phosphate buffer, 44 parts of malic acid.
A kind of preparation method of realizing controlled-release bone cement, including following preparation process：
Step 1）Add graphene oxide in malic acid, ultrasonic disperse is uniform, is subsequently adding potassium alginate, GE fiber
Element, methyl-B-cyclodextrin and locust bean gum, in 60 DEG C of stirring mixing 25min, are cooled to room temperature, obtain mixed liquor A；
Step 2）Tartaric acid, ammonium ceric nitrate, phylloxanthin and phosphatidylcholine are added in phosphate buffer, stirring mixing is equal
It is even, then with step 1）The mixed liquor A of middle preparation stirs mixing 30min at 75 DEG C, is cooled to room temperature, obtains mixed liquid B, standby
With；
Step 3）By Arizona bacilli, tricalcium phosphate, nanometer hydroxyapatite, tantalic acid calcium, phytic acid strontium and bismuth oxide mix homogeneously,
1.5 hours are incubated at 260 DEG C, room temperature are naturally cooled to, is obtained compound C, it is standby；
Step 4）By step 2）In mixed liquid B and step 3）In compound C be uniformly mixed, obtain final product realizing controlled-release medical bone
Cement.
Embodiment 5
A kind of realizing controlled-release bone cement, is prepared from by the component of following weight portion：38 parts of Arizona bacilli, tricalcium phosphate 21
Part, 12 parts of nanometer hydroxyapatite, 7.5 parts of tantalic acid calcium, 5.6 parts of phytic acid strontium, 4.8 parts of bismuth oxide, 6 parts of GE-cellulose,
4.3 parts of phylloxanthin, 5 parts of phosphatidylcholine, 3.9 parts of graphene oxide, 5.6 parts of methyl-B-cyclodextrin, 4.8 parts of potassium alginate, wine
3.7 parts of stone acid, 2.2 parts of ammonium ceric nitrate, 3 parts of locust bean gum, 38 parts of phosphate buffer, 42 parts of malic acid.
A kind of preparation method of realizing controlled-release bone cement, including following preparation process：
Step 1）Add graphene oxide in malic acid, ultrasonic disperse is uniform, is subsequently adding potassium alginate, GE fiber
Element, methyl-B-cyclodextrin and locust bean gum, in 65 DEG C of stirring mixing 25min, are cooled to room temperature, obtain mixed liquor A；
Step 2）Tartaric acid, ammonium ceric nitrate, phylloxanthin and phosphatidylcholine are added in phosphate buffer, stirring mixing is equal
It is even, then with step 1）The mixed liquor A of middle preparation stirs mixing 20min at 70 DEG C, is cooled to room temperature, obtains mixed liquid B, standby
With；
Step 3）By Arizona bacilli, tricalcium phosphate, nanometer hydroxyapatite, tantalic acid calcium, phytic acid strontium and bismuth oxide mix homogeneously,
1 hour is incubated at 260 DEG C, room temperature is naturally cooled to, is obtained compound C, it is standby；
Step 4）By step 2）In mixed liquid B and step 3）In compound C be uniformly mixed, obtain final product realizing controlled-release medical bone
Cement.
Comparative example 1
This comparative example with the difference of embodiment 1 is, this comparative example portion include tantalic acid calcium, bismuth oxide and graphene oxide and
Its correlation step, other guide will not be described here with embodiment 1.
Comparative example 2
This comparative example with the difference of embodiment 1 is, this comparative example portion include nanometer hydroxyapatite and phytic acid strontium and its
Correlation step, other guide will not be described here with embodiment 1.
Performance test
Bone cement prepared by above-described embodiment and comparative example is carried out into correlated performance test according to industry standard, its test knot
It is really：
| Porosity/% | Comprcssive strength/MPa | |
| Embodiment 1 | 54 | 26.5 |
| Embodiment 2 | 57 | 28.2 |
| Embodiment 3 | 58 | 29.6 |
| Embodiment 4 | 60 | 32.3 |
| Embodiment 5 | 61 | 33.6 |
| Comparative example 1 | 49 | 22.6 |
| Comparative example 2 | 51 | 17.3 |
The porosity of the bone cement provided by above test result, the present invention is relatively up to 54-61%, can promote bone
Conduction and bone tactophily, improve Healing Rate, shorten the healing therapy cycle, while the comprcssive strength of the bone cement is still located
In higher level, up to 26.5-33.6MPa, the application demand of clinically each side is met.Additionally, preparation provided by the present invention
Method process is simple and combination property is good, can large-scale production application.
Claims (7)
1. a kind of realizing controlled-release bone cement, it is characterised in that be prepared from by the component of following weight portion：Arizona bacilli 28-
45 parts, tricalcium phosphate 15-26 parts, nanometer hydroxyapatite 7-14 parts, tantalic acid calcium 5-11 parts, phytic acid strontium 3-8 parts, bismuth oxide 2-7
Part, GE-cellulose 4-9 parts, phylloxanthin 2-6 parts, phosphatidylcholine 3-7 parts, graphene oxide 2-6 parts, methyl-β-ring
Dextrin 4-8 parts, potassium alginate 3-7 parts, tartaric acid 2-6 parts, ammonium ceric nitrate 1-4 parts, locust bean gum 2-5 parts, phosphate buffer
28-44 parts, malic acid 30-47 parts.
2. realizing controlled-release bone cement according to claim 1, it is characterised in that prepared by the component of following weight portion and
Into：Arizona bacilli 32-44 parts, tricalcium phosphate 17-24 parts, nanometer hydroxyapatite 8-13 parts, tantalic acid calcium 6-10 parts, phytic acid strontium
3.5-7 parts, bismuth oxide 2.4-6.2 parts, GE-cellulose 4.5-7 parts, phylloxanthin 2.2-5.6 parts, phosphatidylcholine 3.8-
6.2 parts, graphene oxide 2.4-5.3 parts, methyl-B-cyclodextrin 4.2-7 parts, potassium alginate 3.8-6.3 parts, tartaric acid 2.2-5
Part, ammonium ceric nitrate 1.6-3.7 parts, locust bean gum 2.8-4.3 parts, phosphate buffer 30-42 parts, malic acid 33-44 parts.
3. realizing controlled-release bone cement according to claim 1, it is characterised in that prepared by the component of following weight portion and
Into：38 parts of Arizona bacilli, 21 parts of tricalcium phosphate, 12 parts of nanometer hydroxyapatite, 7.5 parts of tantalic acid calcium, 5.6 parts of phytic acid strontium, oxidation
4.8 parts of bismuth, 6 parts of GE-cellulose, 4.3 parts of phylloxanthin, 5 parts of phosphatidylcholine, 3.9 parts of graphene oxide, methyl-β-ring
5.6 parts of dextrin, 4.8 parts of potassium alginate, 3.7 parts of tartaric acid, 2.2 parts of ammonium ceric nitrate, 3 parts of locust bean gum, phosphate buffer 38
Part, 42 parts of malic acid.
4. the preparation method of the realizing controlled-release bone cement as described in claim 1-3 is arbitrary, it is characterised in that including following system
Standby step：
Step 1）Add graphene oxide in malic acid, ultrasonic disperse is uniform, is subsequently adding potassium alginate, GE fiber
Element, methyl-B-cyclodextrin and locust bean gum, in 40-70 DEG C of stirring mixing 10-30min, are cooled to room temperature, obtain mixed liquor A；
Step 2）Tartaric acid, ammonium ceric nitrate, phylloxanthin and phosphatidylcholine are added in phosphate buffer, stirring mixing is equal
It is even, then with step 1）The mixed liquor A of middle preparation stirs mixing 15-40min at 50-80 DEG C, is cooled to room temperature, obtains mixed liquor
B, it is standby；
Step 3）By Arizona bacilli, tricalcium phosphate, nanometer hydroxyapatite, tantalic acid calcium, phytic acid strontium and bismuth oxide mix homogeneously,
0.5-2 hours are incubated at 180-320 DEG C, room temperature are naturally cooled to, is obtained compound C, it is standby；
Step 4）By step 2）In mixed liquid B and step 3）In compound C be uniformly mixed, obtain final product realizing controlled-release medical bone
Cement.
5. the preparation method of realizing controlled-release bone cement according to claim 4, it is characterised in that step 1）In, 65
DEG C stirring mixing 25min.
6. the preparation method of realizing controlled-release bone cement according to claim 4, it is characterised in that step 2）In, 70
Stirring mixing 20min at DEG C.
7. the preparation method of realizing controlled-release bone cement according to claim 4, it is characterised in that step 3）In, 260
1 hour is incubated at DEG C.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106620886A (en) * | 2016-12-09 | 2017-05-10 | 苏州纳贝通环境科技有限公司 | Liquid bracket material for bone repair and preparation method thereof |
| CN107648673A (en) * | 2017-09-18 | 2018-02-02 | 暨南大学 | A kind of compound calcium phosphate bone cement and preparation method and application |
| CN112516378A (en) * | 2020-12-02 | 2021-03-19 | 浙江工业大学 | Preparation method of phytic acid/silk fibroin/calcined dolomite bone adhesive |
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| CN112516378A (en) * | 2020-12-02 | 2021-03-19 | 浙江工业大学 | Preparation method of phytic acid/silk fibroin/calcined dolomite bone adhesive |
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