CN106519335A - Medical latex film - Google Patents

Medical latex film Download PDF

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Publication number
CN106519335A
CN106519335A CN201611012243.2A CN201611012243A CN106519335A CN 106519335 A CN106519335 A CN 106519335A CN 201611012243 A CN201611012243 A CN 201611012243A CN 106519335 A CN106519335 A CN 106519335A
Authority
CN
China
Prior art keywords
medical latex
thin film
water
medical
film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201611012243.2A
Other languages
Chinese (zh)
Inventor
缪建良
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wuxi Changan Shuguang Glove Factory
Original Assignee
Wuxi Changan Shuguang Glove Factory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wuxi Changan Shuguang Glove Factory filed Critical Wuxi Changan Shuguang Glove Factory
Priority to CN201611012243.2A priority Critical patent/CN106519335A/en
Publication of CN106519335A publication Critical patent/CN106519335A/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L7/00—Compositions of natural rubber
    • C08L7/02—Latex
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2307/00—Characterised by the use of natural rubber
    • C08J2307/02—Latex
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/011—Nanostructured additives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/08—Stabilised against heat, light or radiation or oxydation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/16—Applications used for films
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
    • C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend

Abstract

The invention discloses a medical latex film. The medical latex film comprises, by weight, 0.01-1% of nano-silver, 0.2-3% of water-soluble chitosan, 0.5-5% of sericin, 10-40% of waterborne polyurethane and the balance natural latex. According to the medical latex film, the escaping concentration of extractable protein can be obviously reduced, the film has a compact structure, and the surface is more flat and smoother.

Description

A kind of medical latex thin film
Technical field
A kind of the present invention relates to field of material technology, more particularly to medical latex thin film.
Background technology
Natural emulsion is a kind of water-base disperse system of natural reproducible, and the rubber with natural emulsion as raw material has Excellent combination property and irreplaceability, are widely used to medicine and hygiene fieldses, such as medical catheter, glove and condom Deng.However, natural latex products still have some performance deficiencies, for example, natural latex products compactness, resistance to ag(e)ing, anti- Bacterium property is poor.More seriously contain some allergic protein matter in latex, easily induce contact dermatitis, urticaria, anaphylaxis The property the sent out anaphylaxiss of asthma constant speed, can cause anaphylactic shock when serious, or even dead.
Many researchs in recent years show, in the infection caused by biomaterial for medical purpose, are because life the reason for 45% When thing material is with human contact, the fiber laminins, glass laminins in blood and tissue, Fibrinogen can adsorb Material surface, forms one layer of albuminous coat, and this layer of albuminous coat is that the hotbed of growth of microorganism, especially antibacterial are easy in this layer of egg Stick on tunica albuginea, then growth and breeding, gradually form the bioactive film of one layer of obstinate hydration polysaccharide property.This layer biological Film can absorb nutrient substance, with certain thickness, produce very strong medicine resistance ability, and traditional antibacterial therapy is to eradicate 's.Thus the infection and other symptoms for causing causes clinical operation and patient significant burden economically.
Therefore, how to improve anti-microbial property and the desensitization performance of medical latex material, be one of difficult problem that this area faces.
The content of the invention
It is an object of the invention to propose a kind of medical latex thin film, enable to leachable albumen effusion concentration it is notable under Drop, thin film have compact texture, surface more flat smooth.
It is that, up to this purpose, the present invention is employed the following technical solutions：
A kind of medical latex thin film, its percentage composition by weight contain：
Nanometer silver 0.01-1%
Water-soluble chitosan 0.2-3%
Sericin 0.5-5%
Aqueous polyurethane 10-40%
Natural emulsion surplus.
Preferably, the consumption of the nanometer silver is 0.01-0.1.
Preferably, the sericin consumption is 0.5-3%.
Preferably, water-soluble chitosan content is 0.5-2%.
Silver ion and antibacterial haptoreaction, cause cell proper constituent destroyed or produce dysfunction and dead.When micro- When amount silver ion is met with microbial cell, as silver ion has higher oxidation-reduction potential (± 0.798V, 25 DEG C), and The latter carries negative charge, by Coulomb attraction, makes the two be closely linked, and silver ion can also the entrance of penetration cell wall In antibacterial body, and react with the sulfydryl in antibacterial, make protein coagulating, destroy the activity of cell synzyme, make cell loss point Split multiplication capacity and dead：Simultaneously silver ion can also destroy microorganism electric transmission system, respiratory system, substance delivery system, Cause microbial cell dead, play bactericidal action.After thalline loses activity, silver ion again can from thalline separate out, Fungicidal property, therefore its durable antibacterial effect is carried out again and again.Meanwhile, in the presence of light, micro silver ion can be played The effect of catalytic active center, can activate air or the oxygen in water, produce hydroxyl radical free radical and active oxygen ion, and they have very Strong oxidability, can destroy the multiplication capacity of microbial cell, suppress or kill antibacterial, play bactericidal action.Due to silver from Son plays catalytic active center, is not consumed in itself, has illumination just can constantly press down bactericidal, thus can reach it is efficient, lasting, The antibacterial action of wide spectrum.
Shitosan has good biocompatibility, and the special work(with anti-inflammation with the histoorgan and cell of human body Energy.The present invention utilizes heterocoagulation blend method, and water-soluble chitosan is incorporated in natural emulsion system.Test shows, water-soluble Property shitosan be attached to the outer surface of natural emulsion microsphere, define a kind of special nucleocapsid structure so that institute is fine and close into thin film Property has obtained very big improvement, and solvent resistance is significantly improved.Leachable albumen test and cell toxicity test show that water soluble shells are gathered Sugar effectively prevent the effusion of water-solubility protein, make albumen escaped quantity minimize below sensitization concentration, modified film material peace Complete not sensitization.
The sericin of the present invention has antioxidation, ultraviolet light, moisture absorption, biocompatibility and antianaphylaxiss, and which individually should Modified for natural rubber, in the range of the addition of 1%-1.5%, the mechanical performance of natural rubber film is best, in 0.1%-1% In the range of addition, water-soluble spilling protein content increases to 1.5mg/g from 1.1mg/g, water-soluble spilling protein content between 1%-2% Increase sharply, during 1% addition, configuration of surface is most smooth.
, with water as solvent, with pollution-free, safe and reliable, good mechanical performance, the compatibility is good, be easy to change for aqueous polyurethane The advantages of property.Anion aqueous polyurethane micelle and natural emulsion micelle are all negatively charged, and two kinds of emulsions can be with arbitrary proportion phase Hold blending.Aqueous polyurethane is intended to improve the flatness of modified film, compactness, mechanical strength, drop with the blending of natural emulsion Low allergic protein effusion, or even the pore defect for making up Cure of Rubber residual.Currently preferred aqueous polyurethane includes, with different Isophorone diisocyanate and polytetrahydrofuran diol, Polyethylene Glycol, polypropylene glycol have synthesized aqueous polyurethane, with poly- tetrahydrochysene furan The aqueous polyurethane muttered as soft section, its comprehensive mechanical property are optimal.Which is carried out into physical blending with natural emulsion, into thin film Tensile strength is slightly reduced apparently higher than natural emulsion thin film, but elongation at break, and leachable albumen effusion concentration is remarkably decreased, Solvent resistance is tested and atomic force collection of illustrative plates shows that blend film has compact texture, blend film surface more flat smooth.
The medical latex thin film of the present invention, which can suppress the water-soluble content for overflowing albumen, and possess bacteriostasis.
Specific embodiment
Technical scheme is further illustrated below by specific embodiment.
Embodiment 1
A kind of medical latex thin film, its percentage composition by weight contain：
Nanometer silver 0.01%
Water-soluble chitosan 0.2%
Sericin 0.5%
Aqueous polyurethane 10%
Natural emulsion surplus.
Embodiment 2
A kind of medical latex thin film, its percentage composition by weight contain：
Nanometer silver 1%
Water-soluble chitosan 3%
Sericin 5%
Aqueous polyurethane 40%
Natural emulsion surplus.
Embodiment 3
A kind of medical latex thin film, its percentage composition by weight contain：
Nanometer silver 0.05%
Water-soluble chitosan 1%
Sericin 2%
Aqueous polyurethane 30%
Natural emulsion surplus.

Claims (4)

1. a kind of medical latex thin film, its percentage composition by weight contain：
Nanometer silver 0.01-1%
Water-soluble chitosan 0.2-3%
Sericin 0.5-5%
Aqueous polyurethane 10-40%
Natural emulsion surplus.
2. medical latex thin film as claimed in claim 1, it is characterised in that the consumption of the nanometer silver is 0.01-0.1.
3. medical latex thin film as claimed in claim 1 or 2, it is characterised in that the sericin consumption is 0.5-3%.
4. the medical latex thin film as described in one of claim 1-3, it is characterised in that water-soluble chitosan content is 0.5- 2%.
CN201611012243.2A 2016-11-17 2016-11-17 Medical latex film Pending CN106519335A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611012243.2A CN106519335A (en) 2016-11-17 2016-11-17 Medical latex film

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611012243.2A CN106519335A (en) 2016-11-17 2016-11-17 Medical latex film

Publications (1)

Publication Number Publication Date
CN106519335A true CN106519335A (en) 2017-03-22

Family

ID=58352309

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201611012243.2A Pending CN106519335A (en) 2016-11-17 2016-11-17 Medical latex film

Country Status (1)

Country Link
CN (1) CN106519335A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108623857A (en) * 2018-04-25 2018-10-09 艾钟 A kind of pure natural latex composition and latex mold cup and preparation method thereof
CN109021331A (en) * 2018-07-09 2018-12-18 苏州市贝克生物科技有限公司 Medical latex film and preparation method thereof
CN111333929A (en) * 2020-03-25 2020-06-26 同曦集团有限公司 Active antibacterial and antiviral glove and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1727381A (en) * 2005-06-03 2006-02-01 陈汝霖 New type products of Nano silver latex, and preparation method
CN101717530A (en) * 2009-11-09 2010-06-02 田晓慧 Natural rubber liquid slurry containing chitosan/sericin and preparation method thereof
CN103834072A (en) * 2012-11-20 2014-06-04 合肥杰事杰新材料股份有限公司 Modified nature latex, preparation method and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1727381A (en) * 2005-06-03 2006-02-01 陈汝霖 New type products of Nano silver latex, and preparation method
CN101717530A (en) * 2009-11-09 2010-06-02 田晓慧 Natural rubber liquid slurry containing chitosan/sericin and preparation method thereof
CN103834072A (en) * 2012-11-20 2014-06-04 合肥杰事杰新材料股份有限公司 Modified nature latex, preparation method and use thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108623857A (en) * 2018-04-25 2018-10-09 艾钟 A kind of pure natural latex composition and latex mold cup and preparation method thereof
CN109021331A (en) * 2018-07-09 2018-12-18 苏州市贝克生物科技有限公司 Medical latex film and preparation method thereof
CN111333929A (en) * 2020-03-25 2020-06-26 同曦集团有限公司 Active antibacterial and antiviral glove and preparation method thereof

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Application publication date: 20170322

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