CN106511568A - 一种肤阴净抑菌洗液及其制备方法与应用 - Google Patents
一种肤阴净抑菌洗液及其制备方法与应用 Download PDFInfo
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Abstract
本发明公开了一种肤阴净抑菌洗液，所述的肤阴净抑菌洗液包括下列组份按照重量份数：蛇床子50‑300份、黄柏60‑200份、白癣皮60‑200份、金银花30‑300份，还包括醋酸氯己定，所述醋酸氯己定为0.1‑0.4％w/v。本发明中的肤阴净抑菌洗液是由中药提取物、醋酸氯己定等经科学配制的抑菌剂，能有效抑制引起皮肤感染的金黄色葡萄球菌、大肠杆菌、白色念珠菌等病原菌，抑菌止痒、清热解毒、舒解皮肤不适，有良好的洁阴、祛除异味作用，经常使用能保持皮肤清洁健康，且对皮肤及***粘膜无刺激无毒副作用，是居家旅行的必备产品。
Description
技术领域
本发明属于医药应用领域，具体涉及一种肤阴净抑菌洗液及其制备方法与应用。
背景技术
正常情况下有需氧菌及厌氧菌寄居在***内，形成正常的***菌群。任何原因将***与菌群之间的生态平衡打破，可形成致病菌条件。临床上常见有：细菌性***病、念珠菌性***炎、滴虫性***炎、老年性***炎、幼女性***炎。***炎是***粘膜及粘膜下结蹄组织的炎症，是妇科常见病。健康妇女由于解破学及生物化学特点，***对病原体的侵入有自然防御功能，当***的自然防御功能遭到破坏，则病原体易于侵入，导致***炎症。通常情况下，幼女及绝经妇女比***及育龄妇女更易受感染。女性外阴炎的发病率极高，75％的女性一生中会患此病一次。目前临床治疗主要选用抗菌消炎的药物口服或外用进行治疗，用到的主要药物有甲硝唑、替硝唑、克霉唑等，治疗方法需要大量使用抗菌素，对人体存在较大的副作用，同时疗效很难持久，容易反复发作，这也是外阴炎和***炎难以根治的原因。而随着中药现代化程度的日益提高，在中药药理和植物化学研究的基础上，越来越多的中药有效成分或有效部位被证明有确切的疗效并得到提纯。
发明内容
发明目的：本发明提供一种肤阴净抑菌洗液，基于祖国医学对治疗女性外阴炎、***炎及其合并发病发病机理的认识和治疗原则，参考现代药理研究成就，按中医组方理论，提取精华，使其发挥清热燥湿，杀虫止痒之功效。
技术方案：一种肤阴净抑菌洗液，所述的肤阴净抑菌洗液包括下列组份按照重量份数：蛇床子50-300份、黄柏60-200份、白癣皮60-200份、金银花30-300份，还包括醋酸氯己定，所述醋酸氯己定为0.1-0.4％w/v。
作为优化：所述的肤阴净抑菌洗液的提取液为淡棕绿色或棕色液体；pH为4.5-5.5。
一种根据所述的肤阴净抑菌洗液的制备方法，具体的配制步骤：将黄柏、金银花加乙醇回流提取三次，每次1小时，滤过，滤液回收乙醇并浓缩至相对密度为1.05-1.15g/m l，温度为35-55℃的清膏；蛇床子、白癣皮加水煎煮三次，每次1小时，合并煎液，浓缩至相对密度为1.05-1.15g/ml，温度为35-55℃的清膏，加乙醇至含醇量达约60％，搅匀，静置过夜，取上清液，回收乙醇后，与醇提液合并，加纯化水至1000ml，加入醋酸氯己定0.1-0.4％w/v，搅匀，过滤，罐装，即得。
一种根据所述的肤阴净抑菌洗液的使用方法：将所述肤阴净抑菌洗液加3倍量的温开水稀释冲洗内外阴或坐浴；或者将所述肤阴净抑菌洗液直接冲洗或涂于患处；或者将所述肤阴净抑菌洗液直接湿润毛巾或棉球、纱布反复擦洗相关部位用以预防消毒。
一种根据所述的肤阴净抑菌洗液的应用：所述的肤阴净抑菌洗液应用于妇科产褥期、人流、经期及性生活前后的清洁消毒，预防病毒及性病感染，也可用于皮癣、皮疹、脚气等可悲化脓菌、真菌等病原菌感染的皮肤及日常洁阴、沐浴、洗脚，保护皮肤不受细菌感染。
有益效果：本发明应用中药提取物制作的妇科外用洗剂，其科学技术含量高，是采用现代化方法制成的中药品种，且无毒副作用，使用方便，起效快，疗程短，效果稳定。
本产品可用于妇科产褥期、人流、经期及性生活前后的清洁消毒，预防病毒及性病感染，也可用于皮癣、皮疹、脚气等可悲化脓菌、真菌等病原菌感染的皮肤及日常洁阴、沐浴、洗脚，保护皮肤不受细菌感染。本发明中的肤阴净抑菌洗液是由中药提取物、醋酸氯己定等经科学配制的抑菌剂，能有效抑制引起皮肤感染的金黄色葡萄球菌、大肠杆菌、白色念珠菌等病原菌，抑菌止痒、清热解毒、舒解皮肤不适，有良好的洁阴、祛除异味作用，经常使用能保持皮肤清洁健康，且对皮肤及***粘膜无刺激无毒副作用，是居家旅行的必备产品。并且，存放于阴凉干燥、儿童不易取处；护肤抗菌液的提取液为淡棕绿色或棕色液体；pH为4.5-5.5。本发明加3倍量温开水稀释冲洗内外阴或坐浴；也可用本品直接冲洗或涂于患处，预防消毒用本品直接湿润毛巾或棉球、纱布反复擦洗相关部位。外用无任何毒副作用，使用方便，杀菌效果稳定，起效快，5分钟时达到100％。
具体实施方式
下面结合具体实施例对本发明进行详细阐述。
具体实施例1：
一种肤阴净抑菌洗液，所述的肤阴净抑菌洗液包括下列组份按照重量份数：蛇床子50份、黄柏60份、白癣皮60份、金银花30份，还包括醋酸氯己定，所述醋酸氯己定为0.1％w/v。所述的肤阴净抑菌洗液的提取液为淡棕绿色或棕色液体；pH为4.5。
所述的肤阴净抑菌洗液的制备方法，具体的配制步骤：将黄柏、金银花加乙醇回流提取三次，每次1小时，滤过，滤液回收乙醇并浓缩至相对密度为1.05g/ml，温度为35℃的清膏；蛇床子、白癣皮加水煎煮三次，每次1小时，合并煎液，浓缩至相对密度为1.05g/m l，温度为35℃的清膏，加乙醇至含醇量达约60％，搅匀，静置过夜，取上清液，回收乙醇后，与醇提液合并，加纯化水至1000ml，加入醋酸氯己定0.1％(w/v)，搅匀，过滤，罐装，即得。
具体实施例2：
一种肤阴净抑菌洗液，所述的肤阴净抑菌洗液包括下列组份按照重量份数：蛇床子300份、黄柏200份、白癣皮200份、金银花300份，还包括醋酸氯己定，所述醋酸氯己定为0.4％w/v。所述的肤阴净抑菌洗液的提取液为淡棕绿色或棕色液体；pH为5.5。
所述的肤阴净抑菌洗液的制备方法，具体的配制步骤：将黄柏、金银花加乙醇回流提取三次，每次1小时，滤过，滤液回收乙醇并浓缩至相对密度为1.15g/ml，温度为55℃的清膏；蛇床子、白癣皮加水煎煮三次，每次1小时，合并煎液，浓缩至相对密度为1.15g/m l，温度为55℃的清膏，加乙醇至含醇量达约60％，搅匀，静置过夜，取上清液，回收乙醇后，与醇提液合并，加纯化水至1000ml，加入醋酸氯己定0.4％(w/v)，搅匀，过滤，罐装，即得。
具体实施例3：
一种肤阴净抑菌洗液，所述的肤阴净抑菌洗液包括下列组份按照重量份数：蛇床子150份、黄柏120份、白癣皮150份、金银花200份，还包括醋酸氯己定，所述醋酸氯己定为0.3％w/v。所述的肤阴净抑菌洗液的提取液为淡棕绿色或棕色液体；pH为5.0。
所述的肤阴净抑菌洗液的制备方法，具体的配制步骤：将黄柏、金银花加乙醇回流提取三次，每次1小时，滤过，滤液回收乙醇并浓缩至相对密度为1.08g/ml，温度为45℃的清膏；蛇床子、白癣皮加水煎煮三次，每次1小时，合并煎液，浓缩至相对密度为1.08g/m l，温度为45℃的清膏，加乙醇至含醇量达约60％，搅匀，静置过夜，取上清液，回收乙醇后，与醇提液合并，加纯化水至1000ml，加入醋酸氯己定0.3％(w/v)，搅匀，过滤，罐装，即得。
为表明本产品的无刺激性，本产品的皮肤刺激试验如下：试验前24h脊柱两侧剪毛(3*3cm2)备皮。取肤阴净抑菌洗液0.5ml滴在2.5cm*2.5cm大小的4层纱布上，敷贴在一侧备皮处，一层油纸覆盖，胶布固定，另一侧做空白对照。4h后用温水洗净，于去除受试物1、24、48h观察、记录皮肤局部反应。实验结果见表1肤阴净抑菌洗液对家兔一次(完整)皮肤刺激反应评分表。实验结论如下：根据皮肤刺激反应强度分级，肤阴净抑菌洗液对家兔皮肤无刺激性。
表1肤阴净抑菌洗液对家兔一次(完整)皮肤刺激反应评分表
为表明本产品的动物***粘膜刺激性，本产品试验如下：(1)样品：肤阴净抑菌洗液原液；对照组用生理盐水。(2)动物：取体重2.2-2.4kg、***口无分泌物的白兔6只。随机分为2组。(3)染毒：将动物仰面固定，暴露出***和***口。将钝头软管用受试液或対照液湿润后轻柔地******(4-5cm)，用注射器缓慢地注入2ml受试液(或生理盐水)，抽出导管，完成染毒。(4)取材：染毒后24h处死动物，破腹取出完整***，纵向切开，观察、记录有无充血、水肿等现象。将***放入10％***溶液中固定24h以上。(5)制片、观察：选取***的两端和中央3个部位制片，作病理组织学检查。评分。实验结果见表2肤阴净抑菌洗液对动物***粘膜刺激反应评分表；实验结论如下：24h观察，各组家兔***粘膜肉眼观察均无明显充血和水肿。
表2肤阴净抑菌洗液对动物***粘膜刺激反应评分表
为表明本产品的动物皮肤***反应结果，本产品试验如下：(1)诱导和激发均采用肤阴净抑菌洗液原液；阴性对照不诱导，激发同实验组。(2)动物：取体重225-263g的健康豚鼠32只，雌雄各半，分性别随机分为2组，每组16只。试验前24h将豚鼠背部左侧剪毛，面积3.0*3.0cm2,备用。(3)诱导：诱导时将0.5ml华津肤阴净抑菌洗液滴在2.0*2.0cm2大小的4层纱布上，敷贴在一组豚鼠脱毛的皮肤上，用一层油纸覆盖，再以无刺激胶布封闭、固定，持续6h.第7天和第14天以同样方法重复一次，另一组阴性对照不诱导。(4)激发：在末次诱导后14天，将0.5ml华津肤阴净抑菌洗液滴在2.0*2.0cm2大小的4层纱布上，敷贴在豚鼠右侧脱毛的皮肤上，用一层油纸覆盖，再以无刺激胶布固定，6h将受试物洗去。24h和48h后观察皮肤反应。实验结果见表3肤阴净抑菌洗液对豚鼠***反应结果；实验结论如下：肤阴净抑菌洗液对实验豚鼠的致敏强度属于轻级。
表3肤阴净抑菌洗液对豚鼠***反应结果
为表明本产品的抗菌效果，本产品微生物指标检测结果如表4微生物污染检测结果、表5对试验菌杀菌效果(％)所示。
表4微生物污染检测结果
表5对试验菌杀菌效果(％)
注：三次实验对照片的细菌总数分别为4.6*104CFU/片、8.4*104CFU/片、1.9*104CFU/片。
本产品可用于妇科产褥期、人流、经期及性生活前后的清洁消毒，预防病毒及性病感染，也可用于皮癣、皮疹、脚气等可悲化脓菌、真菌等病原菌感染的皮肤及日常洁阴、沐浴、洗脚，保护皮肤不受细菌感染。本发明中的肤阴净抑菌洗液是由中药提取物、醋酸氯己定等经科学配制的抑菌剂，能有效抑制引起皮肤感染的金黄色葡萄球菌、大肠杆菌、白色念珠菌等病原菌，抑菌止痒、清热解毒、舒解皮肤不适，有良好的洁阴、祛除异味作用，经常使用能保持皮肤清洁健康，且对皮肤及***粘膜无刺激无毒副作用，是居家旅行的必备产品。并且，存放于阴凉干燥、儿童不易取处；护肤抗菌液的提取液为淡棕绿色或棕色液体；pH为4.5-5.5。本发明加3倍量温开水稀释冲洗内外阴或坐浴；也可用本品直接冲洗或涂于患处，预防消毒用本品直接湿润毛巾或棉球、纱布反复擦洗相关部位。外用无任何毒副作用，使用方便，杀菌效果稳定，起效快，5分钟时达到100％。
本发明不局限于上述最佳实施方式，任何人在本发明的启示下都可得出其他各种形式的产品，但不论在其形状或结构上作任何变化，凡是具有与本申请相同或相近似的技术方案，均落在本发明的保护范围之内。
Claims (5)
1.一种肤阴净抑菌洗液，其特征在于：所述的肤阴净抑菌洗液包括下列组份按照重量份数：蛇床子50-300份、黄柏60-200份、白癣皮60-200份、金银花30-300份，还包括醋酸氯己定，所述醋酸氯己定为0.1-0.4％w/v。
2.根据权利要求1所述的肤阴净抑菌洗液，其特征在于：所述的肤阴净抑菌洗液的提取液为淡棕绿色或棕色液体；pH为4.5-5.5。
3.一种根据权利要求1所述的肤阴净抑菌洗液的制备方法，其特征在于：具体的配制步骤：将黄柏、金银花加乙醇回流提取三次，每次1小时，滤过，滤液回收乙醇并浓缩至相对密度为1.05-1.15g/ml，温度为35-55℃的清膏；蛇床子、白癣皮加水煎煮三次，每次1小时，合并煎液，浓缩至相对密度为1.05-1.15g/ml，温度为35-55℃的清膏，加乙醇至含醇量达约60％，搅匀，静置过夜，取上清液，回收乙醇后，与醇提液合并，加纯化水至1000ml，加入醋酸氯己定0.1-0.4％w/v，搅匀，过滤，罐装，即得。
4.一种根据权利要求1所述的肤阴净抑菌洗液的使用方法，其特征在于：将所述肤阴净抑菌洗液加3倍量的温开水稀释冲洗内外阴或坐浴；或者将所述肤阴净抑菌洗液直接冲洗或涂于患处；或者将所述肤阴净抑菌洗液直接湿润毛巾或棉球、纱布反复擦洗相关部位用以预防消毒。
5.一种根据权利要求1所述的肤阴净抑菌洗液的应用，其特征在于：所述的肤阴净抑菌洗液应用于妇科产褥期、人流、经期及性生活前后的清洁消毒，预防病毒及性病感染，也可用于皮癣、皮疹、脚气等可悲化脓菌、真菌等病原菌感染的皮肤及日常洁阴、沐浴、洗脚，保护皮肤不受细菌感染。
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| CN105902909A (zh) * | 2016-06-15 | 2016-08-31 | 吴鹏飞 | 一种草本泡沫洗液 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113952385A (zh) * | 2021-11-30 | 2022-01-21 | 重庆医药高等专科学校 | 一种抑菌洗液及其制备方法和应用 |
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